{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:00:34Z","timestamp":1791316834383,"version":"4.3.1"},"reference-count":47,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T00:00:00Z","timestamp":1576195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1140\/17"],"award-info":[{"award-number":["1140\/17"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s12035-019-01839-8","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T17:03:47Z","timestamp":1576256627000},"page":"1768-1777","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Progerin-Induced Transcriptional Changes in Huntington\u2019s Disease Human Pluripotent Stem Cell-Derived Neurons"],"prefix":"10.1007","volume":"57","author":[{"given":"Dorit","family":"Cohen-Carmon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matan","family":"Sorek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitaly","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2869-7191","authenticated-orcid":false,"given":"Mundackal S.","family":"Divya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malka","family":"Nissim-Rafinia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Yarom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4777-986X","authenticated-orcid":false,"given":"Eran","family":"Meshorer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,13]]},"reference":[{"issue":"11","key":"1839_CR1","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/j.tins.2010.08.002","volume":"33","author":"AJ Milnerwood","year":"2010","unstructured":"Milnerwood AJ, Raymond LA (2010) Early synaptic pathophysiology in neurodegeneration: insights from Huntington\u2019s disease. Trends Neurosci 33(11):513\u2013523. https:\/\/doi.org\/10.1016\/j.tins.2010.08.002","journal-title":"Trends Neurosci"},{"issue":"4","key":"1839_CR2","doi-asserted-by":"publisher","first-page":"398","DOI":"10.1038\/ng0893-398","volume":"4","author":"SE Andrew","year":"1993","unstructured":"Andrew SE, Goldberg YP, Kremer B, Telenius H, Theilmann J, Adam S, Starr E, Squitieri F et al (1993) The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington\u2019s disease. Nat Genet 4(4):398\u2013403. https:\/\/doi.org\/10.1038\/ng0893-398","journal-title":"Nat Genet"},{"issue":"2","key":"1839_CR3","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/ng1093-168","volume":"5","author":"RH Myers","year":"1993","unstructured":"Myers RH, MacDonald ME, Koroshetz WJ, Duyao MP, Ambrose CM, Taylor SA, Barnes G, Srinidhi J et al (1993) De novo expansion of a (CAG)n repeat in sporadic Huntington\u2019s disease. Nat Genet 5(2):168\u2013173. https:\/\/doi.org\/10.1038\/ng1093-168","journal-title":"Nat Genet"},{"issue":"10","key":"1839_CR4","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrn3570","volume":"14","author":"MA Pouladi","year":"2013","unstructured":"Pouladi MA, Morton AJ, Hayden MR (2013) Choosing an animal model for the study of Huntington\u2019s disease. Nat Rev Neurosci 14(10):708\u2013721. https:\/\/doi.org\/10.1038\/nrn3570","journal-title":"Nat Rev Neurosci"},{"issue":"7","key":"1839_CR5","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.drudis.2014.02.012","volume":"19","author":"Y Chen","year":"2014","unstructured":"Chen Y, Carter RL, Cho IK, Chan AW (2014) Cell-based therapies for Huntington\u2019s disease. Drug Discov Today 19(7):980\u2013984. https:\/\/doi.org\/10.1016\/j.drudis.2014.02.012","journal-title":"Drug Discov Today"},{"issue":"2","key":"1839_CR6","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1097\/WCO.0b013e3283518226","volume":"25","author":"YW Jung","year":"2012","unstructured":"Jung YW, Hysolli E, Kim KY, Tanaka Y, Park IH (2012) Human induced pluripotent stem cells and neurodegenerative disease: prospects for novel therapies. Curr Opin Neurol 25(2):125\u2013130. https:\/\/doi.org\/10.1097\/WCO.0b013e3283518226","journal-title":"Curr Opin Neurol"},{"issue":"4","key":"1839_CR7","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3390\/jcm3041146","volume":"3","author":"T Halevy","year":"2014","unstructured":"Halevy T, Urbach A (2014) Comparing ESC and iPSC-based models for human genetic disorders. J Clin Med 3(4):1146\u20131162. https:\/\/doi.org\/10.3390\/jcm3041146","journal-title":"J Clin Med"},{"issue":"2","key":"1839_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1002\/stem.2747","volume":"36","author":"B Connor","year":"2018","unstructured":"Connor B (2018) Concise review: the use of stem cells for understanding and treating Huntington\u2019s disease. Stem Cells 36(2):146\u2013160. https:\/\/doi.org\/10.1002\/stem.2747","journal-title":"Stem Cells"},{"issue":"43","key":"1839_CR9","doi-asserted-by":"publisher","first-page":"16707","DOI":"10.1073\/pnas.0808488105","volume":"105","author":"L Aubry","year":"2008","unstructured":"Aubry L, Bugi A, Lefort N, Rousseau F, Peschanski M, Perrier AL (2008) Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats. Proc Natl Acad Sci U S A 105(43):16707\u201316712. https:\/\/doi.org\/10.1073\/pnas.0808488105","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"1839_CR10","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.stem.2012.01.021","volume":"10","author":"L Ma","year":"2012","unstructured":"Ma L, Hu B, Liu Y, Vermilyea SC, Liu H, Gao L, Sun Y, Zhang X et al (2012) Human embryonic stem cell-derived GABA neurons correct locomotion deficits in quinolinic acid-lesioned mice. Cell Stem Cell 10(4):455\u2013464. https:\/\/doi.org\/10.1016\/j.stem.2012.01.021","journal-title":"Cell Stem Cell"},{"issue":"2","key":"1839_CR11","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.stem.2012.04.027","volume":"11","author":"Consortium HDi","year":"2012","unstructured":"Consortium HDi (2012) Induced pluripotent stem cells from patients with Huntington\u2019s disease show CAG-repeat-expansion-associated phenotypes. Cell Stem Cell 11(2):264\u2013278. https:\/\/doi.org\/10.1016\/j.stem.2012.04.027","journal-title":"Cell Stem Cell"},{"issue":"2","key":"1839_CR12","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1242\/dev.084608","volume":"140","author":"A Delli Carri","year":"2013","unstructured":"Delli Carri A, Onorati M, Lelos MJ, Castiglioni V, Faedo A, Menon R, Camnasio S, Vuono R et al (2013) Developmentally coordinated extrinsic signals drive human pluripotent stem cell differentiation toward authentic DARPP-32+ medium-sized spiny neurons. Development 140(2):301\u2013312. https:\/\/doi.org\/10.1242\/dev.084608","journal-title":"Development"},{"issue":"6","key":"1839_CR13","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.stem.2013.11.006","volume":"13","author":"JD Miller","year":"2013","unstructured":"Miller JD, Ganat YM, Kishinevsky S, Bowman RL, Liu B, Tu EY, Mandal PK, Vera E et al (2013) Human iPSC-based modeling of late-onset disease via progerin-induced aging. Cell Stem Cell 13(6):691\u2013705. https:\/\/doi.org\/10.1016\/j.stem.2013.11.006","journal-title":"Cell Stem Cell"},{"issue":"3","key":"1839_CR14","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1089\/scd.2010.0120","volume":"20","author":"CK Bradley","year":"2011","unstructured":"Bradley CK, Scott HA, Chami O, Peura TT, Dumevska B, Schmidt U, Stojanov T (2011) Derivation of Huntington\u2019s disease-affected human embryonic stem cell lines. Stem Cells Dev 20(3):495\u2013502. https:\/\/doi.org\/10.1089\/scd.2010.0120","journal-title":"Stem Cells Dev"},{"issue":"5","key":"1839_CR15","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1016\/j.cell.2007.11.019","volume":"131","author":"K Takahashi","year":"2007","unstructured":"Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131(5):861\u2013872. doi:S0092-8674(07)01471-7. https:\/\/doi.org\/10.1016\/j.cell.2007.11.019","journal-title":"Cell"},{"issue":"1","key":"1839_CR16","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","volume":"29","author":"A Dobin","year":"2013","unstructured":"Dobin A, Davis CA, Schlesinger F, Drenkow J, Zaleski C, Jha S, Batut P, Chaisson M et al (2013) STAR: ultrafast universal RNA-seq aligner. Bioinformatics 29(1):15\u201321. https:\/\/doi.org\/10.1093\/bioinformatics\/bts635","journal-title":"Bioinformatics"},{"issue":"10","key":"1839_CR17","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1101\/gr.207902.116","volume":"26","author":"A Derr","year":"2016","unstructured":"Derr A, Yang C, Zilionis R, Sergushichev A, Blodgett DM, Redick S, Bortell R, Luban J et al (2016) End sequence analysis toolkit (ESAT) expands the extractable information from single-cell RNA-seq data. Genome Res 26(10):1397\u20131410. https:\/\/doi.org\/10.1101\/gr.207902.116","journal-title":"Genome Res"},{"issue":"D1","key":"1839_CR18","doi-asserted-by":"publisher","first-page":"D183","DOI":"10.1093\/nar\/gkw1138","volume":"45","author":"H Mi","year":"2017","unstructured":"Mi H, Huang X, Muruganujan A, Tang H, Mills C, Kang D, Thomas PD (2017) PANTHER version 11: expanded annotation data from gene ontology and Reactome pathways, and data analysis tool enhancements. Nucleic Acids Res 45(D1):D183\u2013D189. https:\/\/doi.org\/10.1093\/nar\/gkw1138","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1839_CR19","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1038\/nbt.1529","volume":"27","author":"SM Chambers","year":"2009","unstructured":"Chambers SM, Fasano CA, Papapetrou EP, Tomishima M, Sadelain M, Studer L (2009) Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 27(3):275\u2013280. https:\/\/doi.org\/10.1038\/nbt.1529","journal-title":"Nat Biotechnol"},{"issue":"9","key":"1839_CR20","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1002\/stem.1462","volume":"31","author":"C Nicoleau","year":"2013","unstructured":"Nicoleau C, Varela C, Bonnefond C, Maury Y, Bugi A, Aubry L, Viegas P, Bourgois-Rocha F et al (2013) Embryonic stem cells neural differentiation qualifies the role of Wnt\/beta-catenin signals in human telencephalic specification and regionalization. Stem Cells 31(9):1763\u20131774. https:\/\/doi.org\/10.1002\/stem.1462","journal-title":"Stem Cells"},{"issue":"5","key":"1839_CR21","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1111\/gtc.12136","volume":"19","author":"K Matsuda","year":"2014","unstructured":"Matsuda K, Kondoh H (2014) Dkk1-dependent inhibition of Wnt signaling activates Hesx1 expression through its 5\u2032 enhancer and directs forebrain precursor development. Genes Cells 19(5):374\u2013385. https:\/\/doi.org\/10.1111\/gtc.12136","journal-title":"Genes Cells"},{"issue":"7264","key":"1839_CR22","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/nature08356","volume":"461","author":"SM Huang","year":"2009","unstructured":"Huang SM, Mishina YM, Liu S, Cheung A, Stegmeier F, Michaud GA, Charlat O, Wiellette E et al (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461(7264):614\u2013620. https:\/\/doi.org\/10.1038\/nature08356","journal-title":"Nature"},{"issue":"22","key":"1839_CR23","doi-asserted-by":"publisher","first-page":"14071","DOI":"10.1073\/pnas.182542899","volume":"99","author":"JK Chen","year":"2002","unstructured":"Chen JK, Taipale J, Young KE, Maiti T, Beachy PA (2002) Small molecule modulation of smoothened activity. Proc Natl Acad Sci U S A 99(22):14071\u201314076. https:\/\/doi.org\/10.1073\/pnas.182542899","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"1839_CR24","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1124\/mol.112.084590","volume":"83","author":"T Gorojankina","year":"2013","unstructured":"Gorojankina T, Hoch L, Faure H, Roudaut H, Traiffort E, Schoenfelder A, Girard N, Mann A et al (2013) Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of smoothened. Mol Pharmacol 83(5):1020\u20131029. https:\/\/doi.org\/10.1124\/mol.112.084590","journal-title":"Mol Pharmacol"},{"key":"1839_CR25","doi-asserted-by":"publisher","first-page":"15535","DOI":"10.1038\/srep15535","volume":"5","author":"H Ge","year":"2015","unstructured":"Ge H, Tan L, Wu P, Yin Y, Liu X, Meng H, Cui G, Wu N et al (2015) Poly-L-ornithine promotes preferred differentiation of neural stem\/progenitor cells via ERK signalling pathway. Sci Rep 5:15535. https:\/\/doi.org\/10.1038\/srep15535","journal-title":"Sci Rep"},{"issue":"1","key":"1839_CR26","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1006\/exnr.2000.7519","volume":"167","author":"T Prapong","year":"2001","unstructured":"Prapong T, Uemura E, Hsu WH (2001) G protein and cAMP-dependent protein kinase mediate amyloid beta-peptide inhibition of neuronal glucose uptake. Exp Neurol 167(1):59\u201364. https:\/\/doi.org\/10.1006\/exnr.2000.7519","journal-title":"Exp Neurol"},{"issue":"4","key":"1839_CR27","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1038\/nrn1078","volume":"4","author":"MV Chao","year":"2003","unstructured":"Chao MV (2003) Neurotrophins and their receptors: a convergence point for many signalling pathways. Nat Rev Neurosci 4(4):299\u2013309. https:\/\/doi.org\/10.1038\/nrn1078","journal-title":"Nat Rev Neurosci"},{"issue":"19","key":"1839_CR28","doi-asserted-by":"publisher","first-page":"5043","DOI":"10.1523\/JNEUROSCI.5187-06.2007","volume":"27","author":"E Chorev","year":"2007","unstructured":"Chorev E, Yarom Y, Lampl I (2007) Rhythmic episodes of subthreshold membrane potential oscillations in the rat inferior olive nuclei in vivo. J Neurosci 27(19):5043\u20135052. https:\/\/doi.org\/10.1523\/JNEUROSCI.5187-06.2007","journal-title":"J Neurosci"},{"issue":"7","key":"1839_CR29","doi-asserted-by":"publisher","first-page":"1424","DOI":"10.1002\/stem.1123","volume":"30","author":"EL West","year":"2012","unstructured":"West EL, Gonzalez-Cordero A, Hippert C, Osakada F, Martinez-Barbera JP, Pearson RA, Sowden JC, Takahashi M et al (2012) Defining the integration capacity of embryonic stem cell-derived photoreceptor precursors. Stem Cells 30(7):1424\u20131435. https:\/\/doi.org\/10.1002\/stem.1123","journal-title":"Stem Cells"},{"issue":"4","key":"1839_CR30","doi-asserted-by":"publisher","first-page":"E762","DOI":"10.1073\/pnas.1715865115","volume":"115","author":"P Conforti","year":"2018","unstructured":"Conforti P, Besusso D, Bocchi VD, Faedo A, Cesana E, Rossetti G, Ranzani V, Svendsen CN et al (2018) Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes. Proc Natl Acad Sci U S A 115(4):E762\u2013E771. https:\/\/doi.org\/10.1073\/pnas.1715865115","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7378","key":"1839_CR31","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/nature10671","volume":"480","author":"P Koch","year":"2011","unstructured":"Koch P, Breuer P, Peitz M, Jungverdorben J, Kesavan J, Poppe D, Doerr J, Ladewig J et al (2011) Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease. Nature 480(7378):543\u2013546. https:\/\/doi.org\/10.1038\/nature10671","journal-title":"Nature"},{"issue":"6937","key":"1839_CR32","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1038\/nature01629","volume":"423","author":"M Eriksson","year":"2003","unstructured":"Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, Scott L, Erdos MR, Robbins CM et al (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423(6937):293\u2013298. https:\/\/doi.org\/10.1038\/nature01629","journal-title":"Nature"},{"issue":"7","key":"1839_CR33","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1038\/nm0708-713","volume":"14","author":"E Meshorer","year":"2008","unstructured":"Meshorer E, Gruenbaum Y (2008) Rejuvenating premature aging. Nat Med 14(7):713\u2013715. doi:nm0708-713. https:\/\/doi.org\/10.1038\/nm0708-713","journal-title":"Nat Med"},{"issue":"4","key":"1839_CR34","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.bbrc.2012.04.058","volume":"421","author":"T Sieprath","year":"2012","unstructured":"Sieprath T, Darwiche R, De Vos WH (2012) Lamins as mediators of oxidative stress. Biochem Biophys Res Commun 421(4):635\u2013639. https:\/\/doi.org\/10.1016\/j.bbrc.2012.04.058","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1839_CR35","doi-asserted-by":"publisher","first-page":"53","DOI":"10.5114\/pm.2015.49532","volume":"14","author":"A Skoczynska","year":"2015","unstructured":"Skoczynska A, Budzisz E, Dana A, Rotsztejn H (2015) New look at the role of progerin in skin aging. Menopause Review-Przeglad Menopauzalny 14(1):53\u201358. https:\/\/doi.org\/10.5114\/pm.2015.49532","journal-title":"Menopause Review-Przeglad Menopauzalny"},{"issue":"7","key":"1839_CR36","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1038\/nm1266","volume":"11","author":"B Liu","year":"2005","unstructured":"Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM et al (2005) Genomic instability in laminopathy-based premature aging. Nat Med 11(7):780\u2013785. https:\/\/doi.org\/10.1038\/nm1266","journal-title":"Nat Med"},{"issue":"5","key":"1839_CR37","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1038\/nn.4532","volume":"20","author":"RG Lim","year":"2017","unstructured":"Lim RG, Salazar LL, Wilton DK, King AR, Stocksdale JT, Sharifabad D, Lau AL, Stevens B et al (2017) Developmental alterations in Huntington\u2019s disease neural cells and pharmacological rescue in cells and mice. Nat Neurosci 20(5):648\u2013660. https:\/\/doi.org\/10.1038\/nn.4532","journal-title":"Nat Neurosci"},{"issue":"5","key":"1839_CR38","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1016\/j.neuron.2016.02.003","volume":"89","author":"F Saudou","year":"2016","unstructured":"Saudou F, Humbert S (2016) The biology of Huntingtin. Neuron 89(5):910\u2013926. https:\/\/doi.org\/10.1016\/j.neuron.2016.02.003","journal-title":"Neuron"},{"issue":"11","key":"1839_CR39","doi-asserted-by":"publisher","first-page":"4372","DOI":"10.1172\/Jci57552","volume":"121","author":"G Keryer","year":"2011","unstructured":"Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelieres FP et al (2011) Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease. J Clin Investig 121(11):4372\u20134382. https:\/\/doi.org\/10.1172\/Jci57552","journal-title":"J Clin Investig"},{"issue":"1","key":"1839_CR40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1212\/WNL.0b013e3181e62076","volume":"75","author":"N Saleh","year":"2010","unstructured":"Saleh N, Moutereau S, Azulay JP, Verny C, Simonin C, Tranchant C, El Hawajri N, Bachoud-Levi AC et al (2010) High insulinlike growth factor I is associated with cognitive decline in Huntington disease. Neurology 75(1):57\u201363. https:\/\/doi.org\/10.1212\/WNL.0b013e3181e62076","journal-title":"Neurology"},{"issue":"3","key":"1839_CR41","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1007\/s12035-013-8585-5","volume":"49","author":"C Lopes","year":"2014","unstructured":"Lopes C, Ribeiro M, Duarte AI, Humbert S, Saudou F, de Almeida LP, Hayden M, Rego AC (2014) IGF-1 intranasal administration rescues Huntington\u2019s disease phenotypes in YAC128 mice. Mol Neurobiol 49(3):1126\u20131142. https:\/\/doi.org\/10.1007\/s12035-013-8585-5","journal-title":"Mol Neurobiol"},{"key":"1839_CR42","doi-asserted-by":"publisher","first-page":"292","DOI":"10.3389\/fnagi.2014.00292","volume":"6","author":"PB Campos","year":"2014","unstructured":"Campos PB, Paulsen BS, Rehen SK (2014) Accelerating neuronal aging in in vitro model brain disorders: a focus on reactive oxygen species. Front Aging Neurosci 6:292. https:\/\/doi.org\/10.3389\/fnagi.2014.00292","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"1839_CR43","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1007\/s10522-014-9532-1","volume":"15","author":"FCC Tan","year":"2014","unstructured":"Tan FCC, Hutchison ER, Eitan E, Mattson MP (2014) Are there roles for brain cell senescence in aging and neurodegenerative disorders? Biogerontology 15(6):643\u2013660. https:\/\/doi.org\/10.1007\/s10522-014-9532-1","journal-title":"Biogerontology"},{"issue":"10","key":"1839_CR44","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1016\/j.neo.2017.06.005","volume":"19","author":"N Alessio","year":"2017","unstructured":"Alessio N, Capasso S, Ferone A, Di Bernardo G, Cipollaro M, Casale F, Peluso G, Giordano A et al (2017) Misidentified human gene functions with mouse models: the case of the retinoblastoma gene family in senescence. Neoplasia 19(10):781\u2013790. https:\/\/doi.org\/10.1016\/j.neo.2017.06.005","journal-title":"Neoplasia"},{"issue":"2","key":"1839_CR45","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.neuron.2014.10.016","volume":"84","author":"MB Victor","year":"2014","unstructured":"Victor MB, Richner M, Hermanstyne TO, Ransdell JL, Sobieski C, Deng PY, Klyachko VA, Nerbonne JM et al (2014) Generation of human striatal neurons by microRNA-dependent direct conversion of fibroblasts. Neuron 84(2):311\u2013323. https:\/\/doi.org\/10.1016\/j.neuron.2014.10.016","journal-title":"Neuron"},{"issue":"3","key":"1839_CR46","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1038\/s41593-018-0075-7","volume":"21","author":"MB Victor","year":"2018","unstructured":"Victor MB, Richner M, Olsen HE, Lee SW, Monteys AM, Ma C, Huh CJ, Zhang B et al (2018) Striatal neurons directly converted from Huntington\u2019s disease patient fibroblasts recapitulate age-associated disease phenotypes. Nat Neurosci 21(3):341\u2013352. https:\/\/doi.org\/10.1038\/s41593-018-0075-7","journal-title":"Nat Neurosci"},{"key":"1839_CR47","doi-asserted-by":"publisher","unstructured":"Tang Y, Liu ML, Zang T, Zhang CL (2017) Direct reprogramming rather than ipsc-based reprogramming maintains aging hallmarks in human motor neurons. Front Mol Neurosci:10. https:\/\/doi.org\/10.3389\/fnmol.2017.00359","DOI":"10.3389\/fnmol.2017.00359"}],"updated-by":[{"DOI":"10.1007\/s12035-020-01877-7","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01839-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-01839-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-01839-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:41:25Z","timestamp":1607733685000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-01839-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,13]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["1839"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-01839-8","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12035-020-01877-7","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,13]]},"assertion":[{"value":"13 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 January 2020","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"In the original version of the paper, the name of one of the contributing authors, Dr. Mundackal S. Divya (orcid:0000-0002-2869-7191).","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}}]}}