{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T10:51:27Z","timestamp":1770634287930,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,18]],"date-time":"2019-05-18T00:00:00Z","timestamp":1558137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100008725","name":"Agencia Nacional de Investigaci\u00f3n e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PhD studentship"],"award-info":[{"award-number":["PhD studentship"]}],"id":[{"id":"10.13039\/100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011199","name":"FP7 Ideas: European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"crossref","award":["LIDo PhD studentship"],"award-info":[{"award-number":["LIDo PhD studentship"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Programa de Desarrollo en Ciencias B\u00e1sicas"},{"DOI":"10.13039\/501100006049","name":"Comisi\u00f3n Sectorial de Investigaci\u00f3n Cient\u00edfica","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s12035-019-1620-4","type":"journal-article","created":{"date-parts":[[2019,5,19]],"date-time":"2019-05-19T15:13:49Z","timestamp":1558278829000},"page":"7694-7707","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Glutaric Acid Affects Pericyte Contractility and Migration: Possible Implications for GA-I Pathogenesis"],"prefix":"10.1007","volume":"56","author":[{"given":"Eugenia","family":"Isasi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Korte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Abudara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Attwell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6483-1466","authenticated-orcid":false,"given":"Silvia","family":"Olivera-Bravo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,18]]},"reference":[{"key":"1620_CR1","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1055\/s-2007-973761","volume":"27","author":"GF Hoffmann","year":"1996","unstructured":"Hoffmann GF, Athanassopoulos S, Burlina AB, Duran M, de Klerk JB, Lehnert W, Leonard JV, Monavari AA et al (1996) Clinical course, early diagnosis, treatment, and prevention of disease in glutaryl-CoA dehydrogenase deficiency. Neuropediatrics 27:115\u2013123. \n                    https:\/\/doi.org\/10.1055\/s-2007-973761","journal-title":"Neuropediatrics"},{"key":"1620_CR2","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1093\/brain\/awh401","volume":"128","author":"CB Funk","year":"2005","unstructured":"Funk CB, Prasad AN, Frosk P, Sauer S, Kolker S, Greenberg CR, Del Bigio MR (2005) Neuropathological, biochemical and molecular findings in a glutaric acidemia type 1 cohort. Brain 128:711\u2013722. \n                    https:\/\/doi.org\/10.1093\/brain\/awh401","journal-title":"Brain"},{"issue":"1","key":"1620_CR3","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1007\/s10545-016-9999-9","volume":"40","author":"N Boy","year":"2017","unstructured":"Boy N, M\u00fchlhausen C, Maier EM, Heringer J, Assmann B et al (2017) Proposed recommendations for diagnosing and managing individuals with glutaric aciduria type I: Second revision. J Inherit Metab Dis 40(1):75\u2013101. \n                    https:\/\/doi.org\/10.1007\/s10545-016-9999-9","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"1620_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/0006-2944(75)90091-5","volume":"12","author":"SI Goodman","year":"1975","unstructured":"Goodman SI, Markey SP, Moe PG, Miles BS, Teng CC (1975) Glutaric aciduria; a \"new\" disorder of amino acid metabolism. Biochem Med 12(1):12\u201321. \n                    https:\/\/doi.org\/10.1016\/0006-2944(75)90091-5","journal-title":"Biochem Med"},{"issue":"1","key":"1620_CR5","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00006565-200202000-00014","volume":"18","author":"JF Knapp","year":"2002","unstructured":"Knapp JF, Soden SE, Dasouki MJ, Walsh IR (2002) A 9-month-old baby with subdural hematomas, retinal hemorrhages, and developmental delay. Pediatr Emerg Care 18(1):44\u201347. \n                    https:\/\/doi.org\/10.1097\/00006565-200202000-00014","journal-title":"Pediatr Emerg Care"},{"key":"1620_CR6","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1093\/brain\/awm058","volume":"130","author":"KA Strauss","year":"2007","unstructured":"Strauss KA, Lazovic J, Wintermark M, Morton DH (2007) Multimodal imaging of striatal degeneration in Amish patients with glutaryl-CoA dehydrogenase deficiency. Brain 130:1905\u20131920. \n                    https:\/\/doi.org\/10.1093\/brain\/awm058","journal-title":"Brain"},{"key":"1620_CR7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1093\/brain\/awp297","volume":"133","author":"KA Strauss","year":"2010","unstructured":"Strauss KA, Donnelly P, Wintermark M (2010) Cerebral haemodynamics in patients with glutaryl-coenzyme a dehydrogenase deficiency. Brain 133:76\u201392. \n                    https:\/\/doi.org\/10.1093\/brain\/awp297","journal-title":"Brain"},{"key":"1620_CR8","doi-asserted-by":"publisher","first-page":"1764","DOI":"10.1093\/brain\/awp112","volume":"132","author":"I Harting","year":"2009","unstructured":"Harting I, Neumaier-Probst E, Seitz A, Maier EM, Assmann B, Baric I, Troncoso M, M\u00fchlhausen C et al (2009) Dynamic changes of striatal and extrastriatal abnormalities in glutaric aciduria type I. Brain 132:1764\u20131782. \n                    https:\/\/doi.org\/10.1093\/brain\/awp112","journal-title":"Brain"},{"key":"1620_CR9","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/ajmg.c.20008","volume":"121C","author":"KA Strauss","year":"2003","unstructured":"Strauss KA, Morton DH (2003) Type I glutaric aciduria, part 2: a model of acute striatal necrosis. Am J Med Genet C: Semin Med Genet 121C:53\u201370. \n                    https:\/\/doi.org\/10.1002\/ajmg.c.20008","journal-title":"Am J Med Genet C: Semin Med Genet"},{"key":"1620_CR10","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/brain\/awl009","volume":"129","author":"WJ Zinnanti","year":"2006","unstructured":"Zinnanti WJ, Lazovic J, Wolpert EB, Antonetti DA, Smith MB, Connor JR, Woontner M, Goodman SI et al (2006) A diet-induced mouse model for glutaric aciduria type I. Brain 129(Pt 4:899\u2013910. \n                    https:\/\/doi.org\/10.1093\/brain\/awl009","journal-title":"Brain"},{"issue":"6","key":"1620_CR11","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1023\/B:BOLI.0000045766.98718.d6","volume":"27","author":"C M\u00fchlhausen","year":"2004","unstructured":"M\u00fchlhausen C, Erg\u00fcn S, Strauss KA, Koeller DM, Crnic L, Woontner M, Goodman SI, Ullrich K et al (2004) Vascular dysfunction as an additional pathomechanism in glutaric aciduria type I. J Inherit Metab Dis 27(6):829\u2013834. \n                    https:\/\/doi.org\/10.1023\/B:BOLI.0000045766.98718.d6","journal-title":"J Inherit Metab Dis"},{"issue":"2","key":"1620_CR12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1203\/01.pdr.0000197313.44265.cb","volume":"59","author":"C M\u00fchlhausen","year":"2006","unstructured":"M\u00fchlhausen C, Ott N, Chalajour F, Tilki D, Freudenberg F, Shahhossini M, Thiem J, Ullrich K et al (2006) Endothelial effects of 3- hydroxyglutaric acid: Implications for glutaric aciduria type I. Pediatr Res 59(2):196\u2013202. \n                    https:\/\/doi.org\/10.1203\/01.pdr.0000197313.44265.cb","journal-title":"Pediatr Res"},{"key":"1620_CR13","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/2045-8118-11-15","volume":"11","author":"E Isasi","year":"2014","unstructured":"Isasi E, Barbeito L, Olivera-Bravo S (2014) Increased blood\u2013brain barrier permeability and alterations in perivascular astrocytes and pericytes induced by intracisternal glutaric acid. Fluids Barriers CNS 11:15. \n                    https:\/\/doi.org\/10.1186\/2045-8118-11-15","journal-title":"Fluids Barriers CNS"},{"issue":"16","key":"1620_CR14","doi-asserted-by":"publisher","first-page":"4504","DOI":"10.1093\/hmg\/ddv175","volume":"24","author":"S Olivera-Bravo","year":"2015","unstructured":"Olivera-Bravo S, Ribeiro CA, Isasi E, Tr\u00edas E, Leipnitz G et al (2015) Striatal neuronal death mediated by astrocytes from the Gcdh\u2212\/\u2212 mouse model of glutaric acidemia type I. Hum Mol Genet 24(16):4504\u20134515. \n                    https:\/\/doi.org\/10.1093\/hmg\/ddv175","journal-title":"Hum Mol Genet"},{"key":"1620_CR15","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1007\/978-3-319-40764-7_11","volume":"949","author":"S Olivera-Bravo","year":"2016","unstructured":"Olivera-Bravo S, Isasi E, Fern\u00e1ndez A, Casanova G, Rosillo JC, Barbeito L (2016) Astrocyte dysfunction in developmental neurometabolic diseases. Adv Exp Med Biol 949:227\u2013243. \n                    https:\/\/doi.org\/10.1007\/978-3-319-40764-7_11","journal-title":"Adv Exp Med Biol"},{"issue":"1\u20132","key":"1620_CR16","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.ymgme.2011.07.003","volume":"104","author":"KA Strauss","year":"2011","unstructured":"Strauss KA, Brumbaugh J, Duffy A, Wardley B, Robinson D, Hendrickson C, Tortorelli S, Moser AB et al (2011) Safety, efficacy and physiological actions of a lysine-free, arginine-rich formula to treat glutaryl-CoA dehydrogenase deficiency: Focus on cerebral amino acid influx. Mol Genet Metab 104(1\u20132):93\u2013106. \n                    https:\/\/doi.org\/10.1016\/j.ymgme.2011.07.003","journal-title":"Mol Genet Metab"},{"issue":"2","key":"1620_CR17","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1038\/nprot.2014.019","volume":"9","author":"A Mishra","year":"2014","unstructured":"Mishra A, O'Farrell FM, Reynell C, Hamilton NB, Hall CN, Attwell D (2014) Imaging pericytes and capillary diameter in brain slices and isolated retinae. Nat Protoc 9(2):323\u2013336. \n                    https:\/\/doi.org\/10.1038\/nprot.2014.019","journal-title":"Nat Protoc"},{"issue":"12","key":"1620_CR18","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1038\/nn.4428","volume":"19","author":"A Mishra","year":"2016","unstructured":"Mishra A, Reynolds JP, Chen Y, Gourine AV, Rusakov DA, Attwell D (2016) Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles. Nat Neurosci 19(12):1619\u20131627. \n                    https:\/\/doi.org\/10.1038\/nn.4428","journal-title":"Nat Neurosci"},{"issue":"7494","key":"1620_CR19","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1038\/nature13165","volume":"508","author":"CN Hall","year":"2014","unstructured":"Hall CN, Reynell C, Gesslein B, Hamilton NB, Mishra A, Sutherland BA, O\u2019Farrell FM, Buchan AM et al (2014) Capillary pericytes regulate cerebral blood flow in health and disease. Nature 508(7494):55\u201360. \n                    https:\/\/doi.org\/10.1038\/nature13165","journal-title":"Nature"},{"issue":"1","key":"1620_CR20","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1002\/jnr.10107","volume":"67","author":"P Cassina","year":"2002","unstructured":"Cassina P, Peluffo H, Pehar M, Martinez-Palma L, Ressia A, Beckman JS, Est\u00e9vez AG, Barbeito L (2002) Peroxynitrite triggers a phenotypic transformation in spinal cord astrocytes that induces motor neuron apoptosis. J Neurosci Res 67(1):21\u201329. \n                    https:\/\/doi.org\/10.1002\/jnr.10107","journal-title":"J Neurosci Res"},{"issue":"1","key":"1620_CR21","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.mvr.2012.03.008","volume":"84","author":"U Tigges","year":"2012","unstructured":"Tigges U, Welser-Alves JV, Boroujerdi A, Milner R (2012) A novel and simple method for culturing pericytes from mouse brain. Microvasc Res 84(1):74\u201380. \n                    https:\/\/doi.org\/10.1016\/j.mvr.2012.03.008","journal-title":"Microvasc Res"},{"issue":"3","key":"1620_CR22","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0014-4835(88)80025-3","volume":"46","author":"A Das","year":"1998","unstructured":"Das A, Frank RN, Weber ML, Kennedy A, Reidy CA, Mancini MA (1998) ATP causes retinal pericytes to contract in vitro. Exp Eye Res 46(3):349\u2013362. \n                    https:\/\/doi.org\/10.1016\/S0014-4835(88)80025-3","journal-title":"Exp Eye Res"},{"issue":"3","key":"1620_CR23","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1113\/jphysiol.2003.047977","volume":"551","author":"H Kawamura","year":"2003","unstructured":"Kawamura H, Sugiyama T, Wu DM, Kobayashi M, Yamanishi S, Katsumura K, Puro DG (2003) ATP: A vasoactive signal in the pericyte-containing microvasculature of the rat retina. J Physiol 551(3):787\u2013799. \n                    https:\/\/doi.org\/10.1113\/jphysiol.2003.047977","journal-title":"J Physiol"},{"issue":"2","key":"1620_CR24","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1177\/0271678X15610340","volume":"36","author":"D Attwell","year":"2016","unstructured":"Attwell D, Mishra A, Hall CN, O'Farrell FM, Dalkara T (2016) What is a pericyte? J Cereb Blood Flow Metab 36(2):451\u2013455. \n                    https:\/\/doi.org\/10.1177\/0271678X15610340","journal-title":"J Cereb Blood Flow Metab"},{"key":"1620_CR25","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/978-1-61779-452-0_19","volume":"814","author":"C Giaume","year":"2012","unstructured":"Giaume C, Orellana JA, Abudara V, S\u00e1ez JC (2012) Connexin-based channels in astrocytes: How to study their properties. Methods Mol Biol 814:283\u2013303. \n                    https:\/\/doi.org\/10.1007\/978-1-61779-452-0_19","journal-title":"Methods Mol Biol"},{"key":"1620_CR26","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1007\/978-1-4939-3347-1_7","volume":"1395","author":"A Armada","year":"2016","unstructured":"Armada A, Martins C, Spengler G, Molnar J, Amaral L et al (2016) Fluorimetric methods for analysis of permeability, drug transport kinetics, and inhibition of the ABCB1 membrane transporter. Methods Mol Biol 1395:87\u2013103. \n                    https:\/\/doi.org\/10.1007\/978-1-4939-3347-1_7","journal-title":"Methods Mol Biol"},{"key":"1620_CR27","doi-asserted-by":"publisher","first-page":"e20831","DOI":"10.1371\/journal.pone.0020831","volume":"6","author":"S Olivera-Bravo","year":"2011","unstructured":"Olivera-Bravo S, Fern\u00e1ndez A, Sarlab\u00f3s MN, Rosillo JC, Casanova G, Jim\u00e9nez M, Barbeito L (2011) Neonatal astrocyte damage is sufficient to trigger progressive striatal degeneration in a rat model of glutaric acidemia-I. PlosOne 6:e20831\u2013e20840. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0020831","journal-title":"PlosOne"},{"key":"1620_CR28","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/978-1-61779-207-6_2","volume":"769","author":"G Cory","year":"2011","unstructured":"Cory G (2011) Scratch-wound assay. Methods Mol Biol 769:25\u201330. \n                    https:\/\/doi.org\/10.1007\/978-1-61779-207-6_2","journal-title":"Methods Mol Biol"},{"issue":"2","key":"1620_CR29","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s00018-013-1432-z","volume":"71","author":"KY Aguilera","year":"2014","unstructured":"Aguilera KY, Brekken RA (2014) Recruitment and retention: Factors that affect pericyte migration. Cell Mol Life Sci 71(2):299\u2013309. \n                    https:\/\/doi.org\/10.1007\/s00018-013-1432-z","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1620_CR30","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1007\/s00018-015-2050-8","volume":"73","author":"MM Almutairi","year":"2016","unstructured":"Almutairi MM, Gong C, Xu YG, Chang Y, Shi H (2016) Factors controlling permeability of the blood-brain barrier. Cell Mol Life Sci 73(1):57\u201377. \n                    https:\/\/doi.org\/10.1007\/s00018-015-2050-8","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"1620_CR31","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1177\/0271678X16671146","volume":"37","author":"IG Gould","year":"2017","unstructured":"Gould IG, Tsai P, Kleinfeld D, Linninger A (2017) The capillary bed offers the largest hemodynamic resistance to the cortical blood supply. J Cereb Blood Flow Metab 37(1):52\u201368. \n                    https:\/\/doi.org\/10.1177\/0271678X16671146","journal-title":"J Cereb Blood Flow Metab"},{"key":"1620_CR32","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1212\/01.WNL.0000167428.12417.B2","volume":"64","author":"S K\u00fclkens","year":"2005","unstructured":"K\u00fclkens S, Harting I, Sauer S, Zschocke J, Hoffmann GF et al (2005) Late-onset neurologic disease glutaryl-CoA dehydrogenase deficiency. Neurol. 64:142\u20132144. \n                    https:\/\/doi.org\/10.1212\/01.WNL.0000167428.12417.B2","journal-title":"Neurol."},{"issue":"7112","key":"1620_CR33","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1038\/nature05193","volume":"443","author":"CM Peppiatt","year":"2006","unstructured":"Peppiatt CM, Howarth C, Mobbs P, Attwell D (2006) Bidirectional control of CNS capillary diameter by pericytes. Nature 443(7112):700\u2013704. \n                    https:\/\/doi.org\/10.1038\/nature05193","journal-title":"Nature"},{"key":"1620_CR34","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fnene.2010.00005","volume":"2","author":"NB Hamilton","year":"2010","unstructured":"Hamilton NB, Attwell D, Hall CN (2010) Pericyte-mediated regulation of capillary diameter: A component of neurovascular coupling in health and disease. Front Neuroenerg 2:5. \n                    https:\/\/doi.org\/10.3389\/fnene.2010.00005","journal-title":"Front Neuroenerg"},{"key":"1620_CR35","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1016\/j.nbd.2008.09.011","volume":"32","author":"S Olivera","year":"2008","unstructured":"Olivera S, Fernandez A, Latini A, Rosillo JC, Casanova G, Wajner M, Cassina P, Barbeito L (2008) Astrocytic proliferation and mitochondrial dysfunction induced by accumulated glutaric acidemia I (GAI) metabolites: Possible implications for GAI pathogenesis. Neurobiol Dis 32:528\u2013534. \n                    https:\/\/doi.org\/10.1016\/j.nbd.2008.09.011","journal-title":"Neurobiol Dis"},{"issue":"5323","key":"1620_CR36","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1126\/science.277.5323.242","volume":"277","author":"P Lindahl","year":"1997","unstructured":"Lindahl P, Johansson BR, Lev\u00e9en P, Betsholtz C (1997) Pericyte loss and microaneurysm formation in PDGF-B-deficient mice. Science 277(5323):242\u2013245. \n                    https:\/\/doi.org\/10.1126\/science.277.5323.242","journal-title":"Science"},{"issue":"6","key":"1620_CR37","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1161\/01.RES.0000182903.16652.d7","volume":"97","author":"A Armulik","year":"2005","unstructured":"Armulik A, Abramsson A, Betsholtz C (2005) Endothelial\/pericyte interactions. Circ Res 97(6):512\u2013523. \n                    https:\/\/doi.org\/10.1161\/01.RES.0000182903.16652.d7","journal-title":"Circ Res"},{"issue":"2","key":"1620_CR38","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.devcel.2011.07.001","volume":"21","author":"A Armulik","year":"2011","unstructured":"Armulik A, Genov\u00e9 G, Betsholtz C (2011) Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises. Dev Cell 21(2):193\u2013215. \n                    https:\/\/doi.org\/10.1016\/j.devcel.2011.07.001","journal-title":"Dev Cell"},{"issue":"10","key":"1620_CR39","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1055\/s-0029-1239525","volume":"39","author":"A Mahfoud","year":"2004","unstructured":"Mahfoud A, Dom\u00ednguez CL, Rizzo C, Ribes (2004) In utero macrocephaly as clinical manifestation of glutaric aciduria type I. Report of a novel mutation. Annu Rev Neurol 39(10):939\u2013942. \n                    https:\/\/doi.org\/10.1055\/s-0029-1239525","journal-title":"Annu Rev Neurol"},{"issue":"3","key":"1620_CR40","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/MOH.0b013e3282fcc321","volume":"15","author":"GE Davis","year":"2008","unstructured":"Davis GE, Senger DR (2008) Extracellular matrix mediates a molecular balance between vascular morphogenesis and regression. Curr Opin Hematol 15(3):197\u2013203. \n                    https:\/\/doi.org\/10.1097\/MOH.0b013e3282fcc321","journal-title":"Curr Opin Hematol"},{"issue":"6","key":"1620_CR41","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1083\/jcb.200302047","volume":"161","author":"H Gerhardt","year":"2003","unstructured":"Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, Jeltsch M, Mitchell C et al (2003) VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol 161(6):1163\u20131177. \n                    https:\/\/doi.org\/10.1083\/jcb.200302047","journal-title":"J Cell Biol"},{"issue":"7","key":"1620_CR42","doi-asserted-by":"publisher","first-page":"2454","DOI":"10.1172\/JCI60842","volume":"122","author":"AT Argaw","year":"2012","unstructured":"Argaw AT, Asp L, Zhang J, Navrazhina K, Pham T, Mariani JN, Mahase S, Dutta DJ et al (2012) Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. J Clin Invest 122(7):2454\u20132468. \n                    https:\/\/doi.org\/10.1172\/JCI60842","journal-title":"J Clin Invest"},{"key":"1620_CR43","doi-asserted-by":"publisher","first-page":"1548","DOI":"10.1093\/brain\/awv077","volume":"138","author":"C Chapouly","year":"2015","unstructured":"Chapouly C, Tadesse Argaw A, Horng S, Castro K, Zhang J, Asp L, Loo H, Laitman BM et al (2015) Astrocytic TYMP and VEGFA drive blood-brain barrier opening in inflammatory central nervous system lesions. Brain 138(Pt 6:1548\u20131567. \n                    https:\/\/doi.org\/10.1093\/brain\/awv077","journal-title":"Brain"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-1620-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-1620-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-1620-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T23:54:28Z","timestamp":1589673268000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-1620-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,18]]},"references-count":43,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1620"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-1620-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,18]]},"assertion":[{"value":"18 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"This study was performed in accordance with the Principles of Laboratory Animal Care, National Institute of Health of United States of America, NIH, publication no. 85-23 (2011 revision), and approved by the IIBCE Ethical Committee for the Care and Use of Laboratory Animals and from the National Committee for Laboratory Animal Care (CNEA) from Uruguay. All efforts were made to minimize suffering, discomfort and stress to the animals. The number of animals employed in this work was the necessary to produce reliable scientific data.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement"}},{"value":"The authors declare that they have no conflict of interest","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}