{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T16:17:58Z","timestamp":1777047478022,"version":"3.51.4"},"reference-count":94,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo de Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo de Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"],"award-info":[{"award-number":["Programa de Apoyo a Centros con Financiamiento Basal AFB 170005"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PhD Fellowship"],"award-info":[{"award-number":["PhD Fellowship"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PhD Fellowship"],"award-info":[{"award-number":["PhD Fellowship"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002848","name":"Comisi\u00f3n Nacional de Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PAI 77170091"],"award-info":[{"award-number":["PAI 77170091"]}],"id":[{"id":"10.13039\/501100002848","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["PhD fellowship N\u00ba 3120061"],"award-info":[{"award-number":["PhD fellowship N\u00ba 3120061"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11170546"],"award-info":[{"award-number":["11170546"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160513"],"award-info":[{"award-number":["1160513"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008736","name":"Fondo de Fomento al Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1131122"],"award-info":[{"award-number":["1131122"]}],"id":[{"id":"10.13039\/501100008736","id-type":"DOI","asserted-by":"publisher"}]},{"name":"United Nations Educational, Scientific and Cultural Organization (FR); Fondation L'Oreal","award":["For Women In Science International Fellowship"],"award-info":[{"award-number":["For Women In Science International Fellowship"]}]},{"name":"Programa de Apoyo a Centros con Financiamiento Basal","award":["AFB 170004"],"award-info":[{"award-number":["AFB 170004"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1007\/s12035-019-1621-3","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T01:13:49Z","timestamp":1558574029000},"page":"7774-7788","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["GALECTIN-8 Is a Neuroprotective Factor in the Brain that Can Be Neutralized by Human Autoantibodies"],"prefix":"10.1007","volume":"56","author":[{"given":"Evelyn","family":"Pardo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"Barake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan A.","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Oyanadel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sof\u00eda","family":"Espinoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Metz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Retamal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loreto","family":"Massardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheril","family":"Tapia-Rojas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nibaldo C.","family":"Inestrosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Soza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6139-4299","authenticated-orcid":false,"given":"Alfonso","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"issue":"9","key":"1621_CR1","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/nrn1477","volume":"5","author":"SC Benn","year":"2004","unstructured":"Benn SC, Woolf CJ (2004) Adult neuron survival strategies\u2014slamming on the brakes. Nat Rev Neurosci 5(9):686\u2013700. https:\/\/doi.org\/10.1038\/nrn1477","journal-title":"Nat Rev Neurosci"},{"key":"1621_CR2","doi-asserted-by":"publisher","first-page":"e689","DOI":"10.1038\/cddis.2013.220","volume":"4","author":"AJ Kole","year":"2013","unstructured":"Kole AJ, Annis RP, Deshmukh M (2013) Mature neurons: equipped for survival. Cell Death Dis 4:e689. https:\/\/doi.org\/10.1038\/cddis.2013.220","journal-title":"Cell Death Dis"},{"issue":"2","key":"1621_CR3","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1152\/physrev.00011.2017","volume":"98","author":"M Fricker","year":"2018","unstructured":"Fricker M, Tolkovsky AM, Borutaite V, Coleman M, Brown GC (2018) Neuronal cell death. Physiol Rev 98(2):813\u2013880. https:\/\/doi.org\/10.1152\/physrev.00011.2017","journal-title":"Physiol Rev"},{"key":"1621_CR4","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/s41584-018-0156-8","volume":"15","author":"N Schwartz","year":"2019","unstructured":"Schwartz N, Stock AD, Putterman C (2019) Neuropsychiatric lupus: new mechanistic insights and future treatment directions. Nat Rev Rheumatol 15:137\u2013152. https:\/\/doi.org\/10.1038\/s41584-018-0156-8","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"1621_CR5","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1097\/WCO.0000000000000549","volume":"31","author":"A Gonzalez","year":"2018","unstructured":"Gonzalez A, Massardo L (2018) Antibodies and the brain: antiribosomal P protein antibody and the clinical effects in patients with systemic lupus erythematosus. Curr Opin Neurol 31(3):300\u2013305. https:\/\/doi.org\/10.1097\/WCO.0000000000000549","journal-title":"Curr Opin Neurol"},{"key":"1621_CR6","doi-asserted-by":"publisher","unstructured":"Mackay M, Vo A, Tang CC, Small M, Anderson EW, Ploran EJ, Storbeck J, Bascetta B et al (2019) Metabolic and microstructural alterations in the SLE brain correlate with cognitive impairment. J Clin Invest Insight 4(1). https:\/\/doi.org\/10.1172\/jci.insight.124002","DOI":"10.1172\/jci.insight.124002"},{"key":"1621_CR7","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.3389\/fimmu.2017.01101","volume":"8","author":"S Mader","year":"2017","unstructured":"Mader S, Brimberg L, Diamond B (2017) The role of brain-reactive autoantibodies in brain pathology and cognitive impairment. Front Immunol 8:1101. https:\/\/doi.org\/10.3389\/fimmu.2017.01101","journal-title":"Front Immunol"},{"key":"1621_CR8","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3389\/fnins.2017.00672","volume":"11","author":"L Benussi","year":"2017","unstructured":"Benussi L, Binetti G, Ghidoni R (2017) Loss of neuroprotective factors in neurodegenerative dementias: the end or the starting point? Front Neurosci 11:672. https:\/\/doi.org\/10.3389\/fnins.2017.00672","journal-title":"Front Neurosci"},{"issue":"4","key":"1621_CR9","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1111\/jnc.14278","volume":"144","author":"C Tapia-Rojas","year":"2018","unstructured":"Tapia-Rojas C, Inestrosa NC (2018) Wnt signaling loss accelerates the appearance of neuropathological hallmarks of Alzheimer\u2019s disease in J20-APP transgenic and wild-type mice. J Neurochem 144(4):443\u2013465. https:\/\/doi.org\/10.1111\/jnc.14278","journal-title":"J Neurochem"},{"issue":"Suppl","key":"1621_CR10","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1038\/nrn1434","volume":"10","author":"JK Andersen","year":"2004","unstructured":"Andersen JK (2004) Oxidative stress in neurodegeneration: cause or consequence? Nat Med 10(Suppl):S18\u2013S25. https:\/\/doi.org\/10.1038\/nrn1434","journal-title":"Nat Med"},{"key":"1621_CR11","doi-asserted-by":"publisher","unstructured":"Vasta GR, Feng C, Gonzalez-Montalban N, Mancini J, Yang L, Abernathy K, Frost G, Palm C (2017) Functions of galectins as \u2018self\/non-self\u2019-recognition and effector factors. Pathog Dis 75 (5). doi: https:\/\/doi.org\/10.1093\/femspd\/ftx046","DOI":"10.1093\/femspd\/ftx046"},{"issue":"3","key":"1621_CR12","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.immuni.2012.03.004","volume":"36","author":"GA Rabinovich","year":"2012","unstructured":"Rabinovich GA, Croci DO (2012) Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer. Immunity 36(3):322\u2013335. https:\/\/doi.org\/10.1016\/j.immuni.2012.03.004","journal-title":"Immunity"},{"issue":"4","key":"1621_CR13","first-page":"397","volume":"27","author":"H Kaltner","year":"2012","unstructured":"Kaltner H, Gabius HJ (2012) A toolbox of lectins for translating the sugar code: the galectin network in phylogenesis and tumors. Histol Histopathol 27(4):397\u2013416","journal-title":"Histol Histopathol"},{"key":"1621_CR14","doi-asserted-by":"publisher","first-page":"158","DOI":"10.3389\/fnmol.2018.00158","volume":"11","author":"JJ Siew","year":"2018","unstructured":"Siew JJ, Chern Y (2018) Microglial lectins in health and neurological diseases. Front Mol Neurosci 11:158. https:\/\/doi.org\/10.3389\/fnmol.2018.00158","journal-title":"Front Mol Neurosci"},{"issue":"7385","key":"1621_CR15","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1038\/nature10744","volume":"482","author":"TL Thurston","year":"2012","unstructured":"Thurston TL, Wandel MP, von Muhlinen N, Foeglein A, Randow F (2012) Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature 482(7385):414\u2013418. https:\/\/doi.org\/10.1038\/nature10744","journal-title":"Nature"},{"key":"1621_CR16","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.semcdb.2018.02.022","volume":"83","author":"SJ Popa","year":"2018","unstructured":"Popa SJ, Stewart SE, Moreau K (2018) Unconventional secretion of annexins and galectins. Semin Cell Dev Biol 83:42\u201350. https:\/\/doi.org\/10.1016\/j.semcdb.2018.02.022","journal-title":"Semin Cell Dev Biol"},{"issue":"13","key":"1621_CR17","doi-asserted-by":"publisher","first-page":"2213","DOI":"10.1242\/jcs.151159","volume":"128","author":"IR Nabi","year":"2015","unstructured":"Nabi IR, Shankar J, Dennis JW (2015) The galectin lattice at a glance. J Cell Sci 128(13):2213\u20132219. https:\/\/doi.org\/10.1242\/jcs.151159","journal-title":"J Cell Sci"},{"issue":"6","key":"1621_CR18","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1111\/j.1365-2990.2011.01184.x","volume":"37","author":"M Stancic","year":"2011","unstructured":"Stancic M, van Horssen J, Thijssen VL, Gabius HJ, van der Valk P, Hoekstra D, Baron W (2011) Increased expression of distinct galectins in multiple sclerosis lesions. Neuropathol Appl Neurobiol 37(6):654\u2013671. https:\/\/doi.org\/10.1111\/j.1365-2990.2011.01184.x","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"6","key":"1621_CR19","doi-asserted-by":"publisher","first-page":"e0177472","DOI":"10.1371\/journal.pone.0177472","volume":"12","author":"E Pardo","year":"2017","unstructured":"Pardo E, Carcamo C, Uribe-San Martin R, Ciampi E, Segovia-Miranda F, Curkovic-Pena C, Montecino F, Holmes C et al (2017) Galectin-8 as an immunosuppressor in experimental autoimmune encephalomyelitis and a target of human early prognostic antibodies in multiple sclerosis. PLoS One 12(6):e0177472. https:\/\/doi.org\/10.1371\/journal.pone.0177472","journal-title":"PLoS One"},{"issue":"9","key":"1621_CR20","first-page":"1093","volume":"29","author":"MT Elola","year":"2014","unstructured":"Elola MT, Ferragut F, Cardenas Delgado VM, Nugnes LG, Gentilini L, Laderach D, Troncoso MF, Compagno D et al (2014) Expression, localization and function of galectin-8, a tandem-repeat lectin, in human tumors. Histol Histopathol 29(9):1093\u20131105","journal-title":"Histol Histopathol"},{"issue":"1","key":"1621_CR21","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.molcel.2018.03.009","volume":"70","author":"J Jia","year":"2018","unstructured":"Jia J, Abudu YP, Claude-Taupin A, Gu Y, Kumar S, Choi SW, Peters R, Mudd MH et al (2018) Galectins control mTOR in response to endomembrane damage. Mol Cell 70(1):120\u2013135e128. https:\/\/doi.org\/10.1016\/j.molcel.2018.03.009","journal-title":"Mol Cell"},{"issue":"7637","key":"1621_CR22","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1038\/nature21032","volume":"541","author":"J Staring","year":"2017","unstructured":"Staring J, von Castelmur E, Blomen VA, van den Hengel LG, Brockmann M, Baggen J, Thibaut HJ, Nieuwenhuis J et al (2017) PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature 541(7637):412\u2013416. https:\/\/doi.org\/10.1038\/nature21032","journal-title":"Nature"},{"issue":"7","key":"1621_CR23","doi-asserted-by":"publisher","first-page":"2438","DOI":"10.1074\/jbc.M117.809293","volume":"293","author":"B Falcon","year":"2018","unstructured":"Falcon B, Noad J, McMahon H, Randow F, Goedert M (2018) Galectin-8-mediated selective autophagy protects against seeded tau aggregation. J Biol Chem 293(7):2438\u20132451. https:\/\/doi.org\/10.1074\/jbc.M117.809293","journal-title":"J Biol Chem"},{"issue":"3","key":"1621_CR24","doi-asserted-by":"publisher","first-page":"275","DOI":"10.4067\/S0716-97602013000300008","volume":"46","author":"L Vicuna","year":"2013","unstructured":"Vicuna L, Pardo E, Curkovic C, Doger R, Oyanadel C, Metz C, Massardo L, Gonzalez A et al (2013) Galectin-8 binds to LFA-1, blocks its interaction with ICAM-1 and is counteracted by anti-Gal-8 autoantibodies isolated from lupus patients. Biol Res 46(3):275\u2013280. https:\/\/doi.org\/10.4067\/S0716-97602013000300008","journal-title":"Biol Res"},{"issue":"2","key":"1621_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/icb.2015.72","volume":"94","author":"JF Sampson","year":"2016","unstructured":"Sampson JF, Suryawanshi A, Chen WS, Rabinovich GA, Panjwani N (2016) Galectin-8 promotes regulatory T-cell differentiation by modulating IL-2 and TGFbeta signaling. Immunol Cell Biol 94(2):213\u2013219. https:\/\/doi.org\/10.1038\/icb.2015.72","journal-title":"Immunol Cell Biol"},{"issue":"Pt 13","key":"1621_CR26","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1242\/jcs.113.13.2385","volume":"113","author":"YR Hadari","year":"2000","unstructured":"Hadari YR, Arbel-Goren R, Levy Y, Amsterdam A, Alon R, Zakut R, Zick Y (2000) Galectin-8 binding to integrins inhibits cell adhesion and induces apoptosis. J Cell Sci 113(Pt 13):2385\u20132397","journal-title":"J Cell Sci"},{"issue":"11","key":"1621_CR27","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1093\/glycob\/cwg102","volume":"13","author":"N Nishi","year":"2003","unstructured":"Nishi N, Shoji H, Seki M, Itoh A, Miyanaka H, Yuube K, Hirashima M, Nakamura T (2003) Galectin-8 modulates neutrophil function via interaction with integrin alphaM. Glycobiology 13(11):755\u2013763","journal-title":"Glycobiology"},{"issue":"4","key":"1621_CR28","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.yexcr.2005.10.025","volume":"312","author":"C Carcamo","year":"2006","unstructured":"Carcamo C, Pardo E, Oyanadel C, Bravo-Zehnder M, Bull P, Caceres M, Martinez J, Massardo L et al (2006) Galectin-8 binds specific beta1 integrins and induces polarized spreading highlighted by asymmetric lamellipodia in Jurkat T cells. Exp Cell Res 312(4):374\u2013386. https:\/\/doi.org\/10.1016\/j.yexcr.2005.10.025","journal-title":"Exp Cell Res"},{"issue":"33","key":"1621_CR29","doi-asserted-by":"publisher","first-page":"31285","DOI":"10.1074\/jbc.M100340200","volume":"276","author":"Y Levy","year":"2001","unstructured":"Levy Y, Arbel-Goren R, Hadari YR, Eshhar S, Ronen D, Elhanany E, Geiger B, Zick Y (2001) Galectin-8 functions as a matricellular modulator of cell adhesion. J Biol Chem 276(33):31285\u201331295","journal-title":"J Biol Chem"},{"issue":"19","key":"1621_CR30","doi-asserted-by":"publisher","first-page":"12670","DOI":"10.1074\/jbc.M808949200","volume":"284","author":"A Norambuena","year":"2009","unstructured":"Norambuena A, Metz C, Vicuna L, Silva A, Pardo E, Oyanadel C, Massardo L, Gonzalez A et al (2009) Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1\/2 activation supported by protein kinase A down-regulation. J Biol Chem 284(19):12670\u201312679. https:\/\/doi.org\/10.1074\/jbc.M808949200","journal-title":"J Biol Chem"},{"issue":"5","key":"1621_CR31","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1046\/j.1471-4159.2001.00173.x","volume":"76","author":"DS Gary","year":"2001","unstructured":"Gary DS, Mattson MP (2001) Integrin signaling via the PI3-kinase-Akt pathway increases neuronal resistance to glutamate-induced apoptosis. J Neurochem 76(5):1485\u20131496","journal-title":"J Neurochem"},{"issue":"4","key":"1621_CR32","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1046\/j.1471-4159.2003.01579.x","volume":"84","author":"DS Gary","year":"2003","unstructured":"Gary DS, Milhavet O, Camandola S, Mattson MP (2003) Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. J Neurochem 84(4):878\u2013890","journal-title":"J Neurochem"},{"issue":"21","key":"1621_CR33","doi-asserted-by":"publisher","first-page":"7791","DOI":"10.1523\/JNEUROSCI.0202-11.2011","volume":"31","author":"S Murase","year":"2011","unstructured":"Murase S, Owens DF, McKay RD (2011) In the newborn hippocampus, neurotrophin-dependent survival requires spontaneous activity and integrin signaling. J Neurosci 31(21):7791\u20137800. https:\/\/doi.org\/10.1523\/JNEUROSCI.0202-11.2011","journal-title":"J Neurosci"},{"issue":"3","key":"1621_CR34","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.mcn.2004.11.004","volume":"28","author":"RM Gibson","year":"2005","unstructured":"Gibson RM, Craig SE, Heenan L, Tournier C, Humphries MJ (2005) Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells. Mol Cell Neurosci 28(3):588\u2013598. https:\/\/doi.org\/10.1016\/j.mcn.2004.11.004","journal-title":"Mol Cell Neurosci"},{"issue":"4","key":"1621_CR35","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3969\/j.issn.1673-5374.2013.04.010","volume":"8","author":"J Wang","year":"2013","unstructured":"Wang J, Yin L, Chen Z (2013) Neuroprotective role of fibronectin in neuron-glial extrasynaptic transmission. Neural Regen Res 8(4):376\u2013382. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2013.04.010","journal-title":"Neural Regen Res"},{"issue":"3","key":"1621_CR36","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1038\/85471","volume":"7","author":"T Sakai","year":"2001","unstructured":"Sakai T, Johnson KJ, Murozono M, Sakai K, Magnuson MA, Wieloch T, Cronberg T, Isshiki A et al (2001) Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis. Nat Med 7(3):324\u2013330. https:\/\/doi.org\/10.1038\/85471","journal-title":"Nat Med"},{"issue":"6","key":"1621_CR37","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1177\/0961203308099973","volume":"18","author":"L Massardo","year":"2009","unstructured":"Massardo L, Metz C, Pardo E, Mezzano V, Babul M, Jarpa E, Guzman AM, Andre S et al (2009) Autoantibodies against galectin-8: their specificity, association with lymphopenia in systemic lupus erythematosus and detection in rheumatoid arthritis and acute inflammation. Lupus 18(6):539\u2013546. https:\/\/doi.org\/10.1177\/0961203308099973","journal-title":"Lupus"},{"issue":"2","key":"1621_CR38","doi-asserted-by":"publisher","first-page":"159","DOI":"10.4067\/S0034-98872006000200004","volume":"134","author":"E Pardo","year":"2006","unstructured":"Pardo E, Carcamo C, Massardo L, Mezzano V, Jacobelli S, Gonzalez A, Soza A (2006) Antibodies against galectin-8 in patients with systemic lupus erythematosus. Rev Med Chil 134(2):159\u2013166","journal-title":"Rev Med Chil"},{"issue":"2","key":"1621_CR39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1523\/JNEUROSCI.04-02-00394.1984","volume":"4","author":"A Caceres","year":"1984","unstructured":"Caceres A, Binder LI, Payne MR, Bender P, Rebhun L, Steward O (1984) Differential subcellular localization of tubulin and the microtubule-associated protein MAP2 in brain tissue as revealed by immunocytochemistry with monoclonal hybridoma antibodies. J Neurosci 4(2):394\u2013410","journal-title":"J Neurosci"},{"key":"1621_CR40","doi-asserted-by":"publisher","first-page":"19092","DOI":"10.1074\/jbc.M116.722132","volume":"291","author":"VT Ramirez","year":"2016","unstructured":"Ramirez VT, Ramos-Fernandez E, Henriquez JP, Lorenzo A, Inestrosa NC (2016) Wnt-5a\/Frizzled9 receptor signaling through the Galphao\/Gbetagamma complex regulates dendritic spine formation. J Biol Chem 291:19092\u201319107. https:\/\/doi.org\/10.1074\/jbc.M116.722132","journal-title":"J Biol Chem"},{"issue":"1\u20132","key":"1621_CR41","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65(1\u20132):55\u201363","journal-title":"J Immunol Methods"},{"issue":"20","key":"1621_CR42","doi-asserted-by":"publisher","first-page":"5313","DOI":"10.1523\/JNEUROSCI.3934-06.2007","volume":"27","author":"GG Farias","year":"2007","unstructured":"Farias GG, Valles AS, Colombres M, Godoy JA, Toledo EM, Lukas RJ, Barrantes FJ, Inestrosa NC (2007) Wnt-7a induces presynaptic colocalization of alpha 7-nicotinic acetylcholine receptors and adenomatous polyposis coli in hippocampal neurons. J Neurosci 27(20):5313\u20135325. https:\/\/doi.org\/10.1523\/JNEUROSCI.3934-06.2007","journal-title":"J Neurosci"},{"issue":"38","key":"1621_CR43","doi-asserted-by":"publisher","first-page":"8127","DOI":"10.1021\/bi201246t","volume":"50","author":"MC Dinamarca","year":"2011","unstructured":"Dinamarca MC, Weinstein D, Monasterio O, Inestrosa NC (2011) The synaptic protein neuroligin-1 interacts with the amyloid beta-peptide. Is there a role in Alzheimer\u2019s disease? Biochemistry 50(38):8127\u20138137. https:\/\/doi.org\/10.1021\/bi201246t","journal-title":"Biochemistry"},{"key":"1621_CR44","doi-asserted-by":"publisher","first-page":"97","DOI":"10.3389\/fncel.2013.00097","volume":"7","author":"C Silva-Alvarez","year":"2013","unstructured":"Silva-Alvarez C, Arrazola MS, Godoy JA, Ordenes D, Inestrosa NC (2013) Canonical Wnt signaling protects hippocampal neurons from Abeta oligomers: role of non-canonical Wnt-5a\/Ca(2+) in mitochondrial dynamics. Front Cell Neurosci 7:97. https:\/\/doi.org\/10.3389\/fncel.2013.00097","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"1621_CR45","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/art.38900","volume":"67","author":"M Bravo-Zehnder","year":"2015","unstructured":"Bravo-Zehnder M, Toledo EM, Segovia-Miranda F, Serrano FG, Benito MJ, Metz C, Retamal C, Alvarez A et al (2015) Anti-ribosomal P protein autoantibodies from patients with neuropsychiatric lupus impair memory in mice. Arthritis Rheum 67(1):204\u2013214. https:\/\/doi.org\/10.1002\/art.38900","journal-title":"Arthritis Rheum"},{"issue":"5","key":"1621_CR46","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1091\/mbc.E16-05-0301","volume":"29","author":"C Oyanadel","year":"2018","unstructured":"Oyanadel C, Holmes C, Pardo E, Retamal C, Shaughnessy R, Smith P, Cortes P, Bravo-Zehnder M et al (2018) Galectin-8 induces partial epithelial-mesenchymal transition with invasive tumorigenic capabilities involving a FAK\/EGFR\/proteasome pathway in Madin-Darby canine kidney cells. Mol Biol Cell 29(5):557\u2013574. https:\/\/doi.org\/10.1091\/mbc.E16-05-0301","journal-title":"Mol Biol Cell"},{"issue":"6","key":"1621_CR47","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1038\/nbt822","volume":"21","author":"DM Valenzuela","year":"2003","unstructured":"Valenzuela DM, Murphy AJ, Frendewey D, Gale NW, Economides AN, Auerbach W, Poueymirou WT, Adams NC et al (2003) High-throughput engineering of the mouse genome coupled with high-resolution expression analysis. Nat Biotechnol 21(6):652\u2013659. https:\/\/doi.org\/10.1038\/nbt822","journal-title":"Nat Biotechnol"},{"issue":"1","key":"1621_CR48","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nbt1263","volume":"25","author":"WT Poueymirou","year":"2007","unstructured":"Poueymirou WT, Auerbach W, Frendewey D, Hickey JF, Escaravage JM, Esau L, Dore AT, Stevens S et al (2007) F0 generation mice fully derived from gene-targeted embryonic stem cells allowing immediate phenotypic analyses. Nat Biotechnol 25(1):91\u201399. https:\/\/doi.org\/10.1038\/nbt1263","journal-title":"Nat Biotechnol"},{"key":"1621_CR49","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/art.39081","volume":"67","author":"F Segovia-Miranda","year":"2015","unstructured":"Segovia-Miranda F, Serrano F, Dyrda A, Ampuero E, Retamal C, Bravo-Zehnder M, Parodi J, Zamorano P et al (2015) Pathogenicity of lupus anti-ribosomal p antibodies: role of cross-reacting neuronal surface p-antigen in glutamatergic transmission and plasticity. Arthritis Rheum 67:1598\u20131610. https:\/\/doi.org\/10.1002\/art.39081","journal-title":"Arthritis Rheum"},{"issue":"6","key":"1621_CR50","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1523\/JNEUROSCI.0862-13.2014","volume":"34","author":"JY Vargas","year":"2014","unstructured":"Vargas JY, Fuenzalida M, Inestrosa NC (2014) In vivo activation of Wnt signaling pathway enhances cognitive function of adult mice and reverses cognitive deficits in an Alzheimer\u2019s disease model. J Neurosci 34(6):2191\u20132202. https:\/\/doi.org\/10.1523\/JNEUROSCI.0862-13.2014","journal-title":"J Neurosci"},{"key":"1621_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2007.12.049","volume":"1198","author":"CJ Feeney","year":"2008","unstructured":"Feeney CJ, Frantseva MV, Carlen PL, Pennefather PS, Shulyakova N, Shniffer C, Mills LR (2008) Vulnerability of glial cells to hydrogen peroxide in cultured hippocampal slices. Brain Res 1198:1\u201315. https:\/\/doi.org\/10.1016\/j.brainres.2007.12.049","journal-title":"Brain Res"},{"issue":"5","key":"1621_CR52","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1007\/s00424-009-0672-0","volume":"458","author":"FJ Gerich","year":"2009","unstructured":"Gerich FJ, Funke F, Hildebrandt B, Fasshauer M, Muller M (2009) H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus. Pflugers Arch 458(5):937\u2013952. https:\/\/doi.org\/10.1007\/s00424-009-0672-0","journal-title":"Pflugers Arch"},{"issue":"5","key":"1621_CR53","doi-asserted-by":"publisher","first-page":"4473","DOI":"10.1007\/s12035-017-0613-4","volume":"55","author":"C Tapia-Rojas","year":"2018","unstructured":"Tapia-Rojas C, Carvajal FJ, Mira RG, Arce C, Lerma-Cabrera JM, Orellana JA, Cerpa W, Quintanilla RA (2018) Adolescent binge alcohol exposure affects the brain function through mitochondrial impairment. Mol Neurobiol 55(5):4473\u20134491. https:\/\/doi.org\/10.1007\/s12035-017-0613-4","journal-title":"Mol Neurobiol"},{"issue":"1\u20133","key":"1621_CR54","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ejphar.2010.01.012","volume":"633","author":"NJ Patel","year":"2010","unstructured":"Patel NJ, Chen MJ, Russo-Neustadt AA (2010) Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons. Eur J Pharmacol 633(1\u20133):1\u20139. https:\/\/doi.org\/10.1016\/j.ejphar.2010.01.012","journal-title":"Eur J Pharmacol"},{"issue":"8","key":"1621_CR55","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","volume":"15","author":"A Chamorro","year":"2016","unstructured":"Chamorro A, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: Targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15(8):869\u2013881. https:\/\/doi.org\/10.1016\/S1474-4422(16)00114-9","journal-title":"Lancet Neurol"},{"key":"1621_CR56","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.pneurobio.2013.11.006","volume":"115","author":"TW Lai","year":"2014","unstructured":"Lai TW, Zhang S, Wang YT (2014) Excitotoxicity and stroke: identifying novel targets for neuroprotection. Prog Neurobiol 115:157\u2013188. https:\/\/doi.org\/10.1016\/j.pneurobio.2013.11.006","journal-title":"Prog Neurobiol"},{"issue":"2","key":"1621_CR57","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1038\/sj.mp.4001208","volume":"8","author":"GV De Ferrari","year":"2003","unstructured":"De Ferrari GV, Chacon MA, Barria MI, Garrido JL, Godoy JA, Olivares G, Reyes AE, Alvarez A et al (2003) Activation of Wnt signaling rescues neurodegeneration and behavioral impairments induced by beta-amyloid fibrils. Mol Psychiatry 8(2):195\u2013208. https:\/\/doi.org\/10.1038\/sj.mp.4001208","journal-title":"Mol Psychiatry"},{"issue":"1","key":"1621_CR58","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1006\/excr.2000.5099","volume":"263","author":"JD Whittard","year":"2001","unstructured":"Whittard JD, Akiyama SK (2001) Activation of beta1 integrins induces cell-cell adhesion. Exp Cell Res 263(1):65\u201376. https:\/\/doi.org\/10.1006\/excr.2000.5099","journal-title":"Exp Cell Res"},{"issue":"4","key":"1621_CR59","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1097\/RHU.0b013e3181a90cd8","volume":"15","author":"L Massardo","year":"2009","unstructured":"Massardo L, Suarez-Almazor ME, Cardiel MH, Nava A, Levy RA, Laurindo I, Soriano ER, Acevedo-Vazquez E et al (2009) Management of patients with rheumatoid arthritis in Latin America: a consensus position paper from Pan-American League of Associations of Rheumatology and Grupo Latino Americano De Estudio De Artritis Reumatoide. J Clin Rheumatol 15(4):203\u2013210. https:\/\/doi.org\/10.1097\/RHU.0b013e3181a90cd8","journal-title":"J Clin Rheumatol"},{"issue":"3","key":"1621_CR60","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1093\/jnen\/63.3.255","volume":"63","author":"H Takuma","year":"2004","unstructured":"Takuma H, Tomiyama T, Kuida K, Mori H (2004) Amyloid beta peptide-induced cerebral neuronal loss is mediated by caspase-3 in vivo. J Neuropathol Exp Neurol 63(3):255\u2013261","journal-title":"J Neuropathol Exp Neurol"},{"issue":"6","key":"1621_CR61","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0092-8674(94)90131-7","volume":"77","author":"C Behl","year":"1994","unstructured":"Behl C, Davis JB, Lesley R, Schubert D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77(6):817\u2013827","journal-title":"Cell"},{"key":"1621_CR62","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.brainres.2007.01.071","volume":"1143","author":"R Resende","year":"2007","unstructured":"Resende R, Pereira C, Agostinho P, Vieira AP, Malva JO, Oliveira CR (2007) Susceptibility of hippocampal neurons to Abeta peptide toxicity is associated with perturbation of Ca2+ homeostasis. Brain Res 1143:11\u201321. https:\/\/doi.org\/10.1016\/j.brainres.2007.01.071","journal-title":"Brain Res"},{"issue":"13","key":"1621_CR63","doi-asserted-by":"publisher","first-page":"1317","DOI":"10.1056\/NEJMoa0804656","volume":"359","author":"W Hacke","year":"2008","unstructured":"Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, Larrue V, Lees KR et al (2008) Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med 359(13):1317\u20131329. https:\/\/doi.org\/10.1056\/NEJMoa0804656","journal-title":"N Engl J Med"},{"issue":"11","key":"1621_CR64","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1002\/dneu.20950","volume":"71","author":"NJ Gardiner","year":"2011","unstructured":"Gardiner NJ (2011) Integrins and the extracellular matrix: key mediators of development and regeneration of the sensory nervous system. Dev Neurobiol 71(11):1054\u20131072. https:\/\/doi.org\/10.1002\/dneu.20950","journal-title":"Dev Neurobiol"},{"issue":"1","key":"1621_CR65","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2005.04.056","volume":"1054","author":"LR Zhao","year":"2005","unstructured":"Zhao LR, Spellman S, Kim J, Duan WM, McCarthy JB, Low WC (2005) Synthetic fibronectin peptide exerts neuroprotective effects on transient focal brain ischemia in rats. Brain Res 1054(1):1\u20138. https:\/\/doi.org\/10.1016\/j.brainres.2005.04.056","journal-title":"Brain Res"},{"issue":"1","key":"1621_CR66","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.bbrc.2005.01.125","volume":"329","author":"E Farias","year":"2005","unstructured":"Farias E, Lu M, Li X, Schnapp LM (2005) Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway. Biochem Biophys Res Commun 329(1):305\u2013311. https:\/\/doi.org\/10.1016\/j.bbrc.2005.01.125","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"1621_CR67","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.expneurol.2007.05.008","volume":"207","author":"CC Tate","year":"2007","unstructured":"Tate CC, Garcia AJ, LaPlaca MC (2007) Plasma fibronectin is neuroprotective following traumatic brain injury. Exp Neurol 207(1):13\u201322. https:\/\/doi.org\/10.1016\/j.expneurol.2007.05.008","journal-title":"Exp Neurol"},{"issue":"7","key":"1621_CR68","doi-asserted-by":"publisher","first-page":"2665","DOI":"10.1091\/mbc.E02-12-0832","volume":"14","author":"ZL Chen","year":"2003","unstructured":"Chen ZL, Indyk JA, Strickland S (2003) The hippocampal laminin matrix is dynamic and critical for neuronal survival. Mol Biol Cell 14(7):2665\u20132676. https:\/\/doi.org\/10.1091\/mbc.E02-12-0832","journal-title":"Mol Biol Cell"},{"issue":"44","key":"1621_CR69","doi-asserted-by":"publisher","first-page":"27665","DOI":"10.1074\/jbc.272.44.27665","volume":"272","author":"BC Duckworth","year":"1997","unstructured":"Duckworth BC, Cantley LC (1997) Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem 272(44):27665\u201327670","journal-title":"J Biol Chem"},{"key":"1621_CR70","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1038\/msb.2009.4","volume":"5","author":"CC Wang","year":"2009","unstructured":"Wang CC, Cirit M, Haugh JM (2009) PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk. Mol Syst Biol 5:246. https:\/\/doi.org\/10.1038\/msb.2009.4","journal-title":"Mol Syst Biol"},{"key":"1621_CR71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/978-1-4615-0123-7_2","volume":"513","author":"RS Morrison","year":"2002","unstructured":"Morrison RS, Kinoshita Y, Johnson MD, Ghatan S, Ho JT, Garden G (2002) Neuronal survival and cell death signaling pathways. Adv Exp Med Biol 513:41\u201386","journal-title":"Adv Exp Med Biol"},{"issue":"5","key":"1621_CR72","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.1046\/j.1471-4159.2003.02255.x","volume":"88","author":"OG Rossler","year":"2004","unstructured":"Rossler OG, Giehl KM, Thiel G (2004) Neuroprotection of immortalized hippocampal neurones by brain-derived neurotrophic factor and Raf-1 protein kinase: role of extracellular signal-regulated protein kinase and phosphatidylinositol 3-kinase. J Neurochem 88(5):1240\u20131252","journal-title":"J Neurochem"},{"issue":"1","key":"1621_CR73","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.cellsig.2007.07.010","volume":"20","author":"A Parcellier","year":"2008","unstructured":"Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA (2008) PKB and the mitochondria: AKTing on apoptosis. Cell Signal 20(1):21\u201330. https:\/\/doi.org\/10.1016\/j.cellsig.2007.07.010","journal-title":"Cell Signal"},{"issue":"11","key":"1621_CR74","doi-asserted-by":"publisher","first-page":"2050","DOI":"10.1111\/j.1432-1033.2004.04133.x","volume":"271","author":"M Hetman","year":"2004","unstructured":"Hetman M, Gozdz A (2004) Role of extracellular signal regulated kinases 1 and 2 in neuronal survival. Eur J Biochem 271(11):2050\u20132055. https:\/\/doi.org\/10.1111\/j.1432-1033.2004.04133.x","journal-title":"Eur J Biochem"},{"issue":"5392","key":"1621_CR75","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.282.5392.1318","volume":"282","author":"MH Cardone","year":"1998","unstructured":"Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282(5392):1318\u20131321","journal-title":"Science"},{"issue":"3","key":"1621_CR76","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1042\/BJ20081056","volume":"415","author":"V Duronio","year":"2008","unstructured":"Duronio V (2008) The life of a cell: apoptosis regulation by the PI3K\/PKB pathway. Biochem J 415(3):333\u2013344. https:\/\/doi.org\/10.1042\/BJ20081056","journal-title":"Biochem J"},{"key":"1621_CR77","doi-asserted-by":"publisher","first-page":"139","DOI":"10.3389\/fnmol.2016.00139","volume":"9","author":"S John","year":"2016","unstructured":"John S, Mishra R (2016) mRNA transcriptomics of galectins unveils heterogeneous organization in mouse and human brain. Front Mol Neurosci 9:139. https:\/\/doi.org\/10.3389\/fnmol.2016.00139","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"1621_CR78","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1111\/jnc.12148","volume":"125","author":"S Velasco","year":"2013","unstructured":"Velasco S, Diez-Revuelta N, Hernandez-Iglesias T, Kaltner H, Andre S, Gabius HJ, Abad-Rodriguez J (2013) Neuronal Galectin-4 is required for axon growth and for the organization of axonal membrane L1 delivery and clustering. J Neurochem 125(1):49\u201362. https:\/\/doi.org\/10.1111\/jnc.12148","journal-title":"J Neurochem"},{"key":"1621_CR79","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/978-1-4939-1154-7_24","volume":"9","author":"HL Chen","year":"2014","unstructured":"Chen HL, Liao F, Lin TN, Liu FT (2014) Galectins and neuroinflammation. Adv Neurobiol 9:517\u2013542. https:\/\/doi.org\/10.1007\/978-1-4939-1154-7_24","journal-title":"Adv Neurobiol"},{"issue":"6","key":"1621_CR80","doi-asserted-by":"publisher","first-page":"712","DOI":"10.1038\/nn1897","volume":"10","author":"N Plachta","year":"2007","unstructured":"Plachta N, Annaheim C, Bissiere S, Lin S, Ruegg M, Hoving S, Muller D, Poirier F et al (2007) Identification of a lectin causing the degeneration of neuronal processes using engineered embryonic stem cells. Nat Neurosci 10(6):712\u2013719. https:\/\/doi.org\/10.1038\/nn1897","journal-title":"Nat Neurosci"},{"issue":"2","key":"1621_CR81","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.immuni.2012.05.023","volume":"37","author":"SC Starossom","year":"2012","unstructured":"Starossom SC, Mascanfroni ID, Imitola J, Cao L, Raddassi K, Hernandez SF, Bassil R, Croci DO et al (2012) Galectin-1 deactivates classically activated microglia and protects from inflammation-induced neurodegeneration. Immunity 37(2):249\u2013263. https:\/\/doi.org\/10.1016\/j.immuni.2012.05.023","journal-title":"Immunity"},{"issue":"11","key":"1621_CR82","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1111\/j.1460-9568.2006.05207.x","volume":"24","author":"T Lekishvili","year":"2006","unstructured":"Lekishvili T, Hesketh S, Brazier MW, Brown DR (2006) Mouse galectin-1 inhibits the toxicity of glutamate by modifying NR1 NMDA receptor expression. Eur J Neurosci 24(11):3017\u20133025. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.05207.x","journal-title":"Eur J Neurosci"},{"issue":"8","key":"1621_CR83","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1523\/jneurosci.4483-03.2004","volume":"24","author":"H Horie","year":"2004","unstructured":"Horie H, Kadoya T, Hikawa N, Sango K, Inoue H, Takeshita K, Asawa R, Hiroi T et al (2004) Oxidized galectin-1 stimulates macrophages to promote axonal regeneration in peripheral nerves after axotomy. J Neurosci 24(8):1873\u20131880. https:\/\/doi.org\/10.1523\/jneurosci.4483-03.2004","journal-title":"J Neurosci"},{"issue":"22","key":"1621_CR84","doi-asserted-by":"publisher","first-page":"9964","DOI":"10.1523\/JNEUROSCI.19-22-09964.1999","volume":"19","author":"H Horie","year":"1999","unstructured":"Horie H, Inagaki Y, Sohma Y, Nozawa R, Okawa K, Hasegawa M, Muramatsu N, Kawano H et al (1999) Galectin-1 regulates initial axonal growth in peripheral nerves after axotomy. J Neurosci 19(22):9964\u20139974","journal-title":"J Neurosci"},{"issue":"2","key":"1621_CR85","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.expneurol.2007.06.024","volume":"207","author":"S Ishibashi","year":"2007","unstructured":"Ishibashi S, Kuroiwa T, Sakaguchi M, Sun L, Kadoya T, Okano H, Mizusawa H (2007) Galectin-1 regulates neurogenesis in the subventricular zone and promotes functional recovery after stroke. Exp Neurol 207(2):302\u2013313. https:\/\/doi.org\/10.1016\/j.expneurol.2007.06.024","journal-title":"Exp Neurol"},{"issue":"5","key":"1621_CR86","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/(SICI)1097-4547(19981201)54:5<639::AID-JNR9>3.0.CO;2-2","volume":"54","author":"P Pesheva","year":"1998","unstructured":"Pesheva P, Kuklinski S, Schmitz B, Probstmeier R (1998) Galectin-3 promotes neural cell adhesion and neurite growth. J Neurosci Res 54(5):639\u2013654. https:\/\/doi.org\/10.1002\/(SICI)1097-4547(19981201)54:5<639::AID-JNR9>3.0.CO;2-2","journal-title":"J Neurosci Res"},{"issue":"16","key":"1621_CR87","doi-asserted-by":"publisher","first-page":"3601","DOI":"10.1016\/j.febslet.2010.07.028","volume":"584","author":"JY Kim","year":"2010","unstructured":"Kim JY, Kim DH, Kim DS, Kim JH, Jeong SY, Jeon HB, Lee EH, Yang YS et al (2010) Galectin-3 secreted by human umbilical cord blood-derived mesenchymal stem cells reduces amyloid-beta42 neurotoxicity in vitro. FEBS Lett 584(16):3601\u20133608. https:\/\/doi.org\/10.1016\/j.febslet.2010.07.028","journal-title":"FEBS Lett"},{"key":"1621_CR88","doi-asserted-by":"publisher","first-page":"217","DOI":"10.3389\/fnmol.2017.00217","volume":"10","author":"YC Chen","year":"2017","unstructured":"Chen YC, Ma YL, Lin CH, Cheng SJ, Hsu WL, Lee EH (2017) Galectin-3 negatively regulates hippocampus-dependent memory formation through inhibition of integrin signaling and Galectin-3 phosphorylation. Front Mol Neurosci 10:217. https:\/\/doi.org\/10.3389\/fnmol.2017.00217","journal-title":"Front Mol Neurosci"},{"issue":"13","key":"1621_CR89","doi-asserted-by":"publisher","first-page":"1679","DOI":"10.1007\/s00018-007-7044-8","volume":"64","author":"MT Elola","year":"2007","unstructured":"Elola MT, Wolfenstein-Todel C, Troncoso MF, Vasta GR, Rabinovich GA (2007) Galectins: matricellular glycan-binding proteins linking cell adhesion, migration, and survival. Cell Mol Life Sci 64(13):1679\u20131700. https:\/\/doi.org\/10.1007\/s00018-007-7044-8","journal-title":"Cell Mol Life Sci"},{"key":"1621_CR90","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/2045-8118-11-10","volume":"11","author":"T Brinker","year":"2014","unstructured":"Brinker T, Stopa E, Morrison J, Klinge P (2014) A new look at cerebrospinal fluid circulation. FBCNS 11:10. https:\/\/doi.org\/10.1186\/2045-8118-11-10","journal-title":"FBCNS"},{"issue":"3","key":"1621_CR91","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1016\/j.bbadis.2015.10.014","volume":"1862","author":"MJ Simon","year":"2016","unstructured":"Simon MJ, Iliff JJ (2016) Regulation of cerebrospinal fluid (CSF) flow in neurodegenerative, neurovascular and neuroinflammatory disease. Biochim Biophys Acta 1862(3):442\u2013451. https:\/\/doi.org\/10.1016\/j.bbadis.2015.10.014","journal-title":"Biochim Biophys Acta"},{"issue":"147","key":"1621_CR92","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","volume":"4","author":"JJ Iliff","year":"2012","unstructured":"Iliff JJ, Wang M, Liao Y, Plogg BA, Peng W, Gundersen GA, Benveniste H, Vates GE et al (2012) A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 4(147):147ra111. https:\/\/doi.org\/10.1126\/scitranslmed.3003748","journal-title":"Sci Transl Med"},{"issue":"6","key":"1621_CR93","doi-asserted-by":"publisher","first-page":"e0130772","DOI":"10.1371\/journal.pone.0130772","volume":"10","author":"JF Sampson","year":"2015","unstructured":"Sampson JF, Hasegawa E, Mulki L, Suryawanshi A, Jiang S, Chen WS, Rabinovich GA, Connor KM et al (2015) Galectin-8 ameliorates murine autoimmune ocular pathology and promotes a regulatory T cell response. PLoS One 10(6):e0130772. https:\/\/doi.org\/10.1371\/journal.pone.0130772","journal-title":"PLoS One"},{"issue":"6","key":"1621_CR94","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.autrev.2017.04.008","volume":"16","author":"AD Stock","year":"2017","unstructured":"Stock AD, Gelb S, Pasternak O, Ben-Zvi A, Putterman C (2017) The blood brain barrier and neuropsychiatric lupus: new perspectives in light of advances in understanding the neuroimmune interface. Autoimmun Rev 16(6):612\u2013619. https:\/\/doi.org\/10.1016\/j.autrev.2017.04.008","journal-title":"Autoimmun Rev"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-1621-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-019-1621-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-019-1621-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,18]],"date-time":"2022-09-18T12:58:59Z","timestamp":1663505939000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-019-1621-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":94,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["1621"],"URL":"https:\/\/doi.org\/10.1007\/s12035-019-1621-3","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"18 February 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 May 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}