{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T07:06:39Z","timestamp":1774681599623,"version":"3.50.1"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100009398","name":"Medizinische Fakult\u00e4t, RWTH Aachen University","doi-asserted-by":"publisher","award":["START 24\/15"],"award-info":[{"award-number":["START 24\/15"]}],"id":[{"id":"10.13039\/501100009398","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1007\/s12035-020-01909-2","type":"journal-article","created":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T13:03:32Z","timestamp":1585746212000},"page":"2588-2599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["NLRP3 Depletion Fails to Mitigate Inflammation but Restores Diminished Phagocytosis in BV-2 Cells After In Vitro Hypoxia"],"prefix":"10.1007","volume":"57","author":[{"given":"Isabelle","family":"Sch\u00f6lwer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pardes","family":"Habib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Voelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leoni","family":"Rolfes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cordian","family":"Beyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Slowik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,1]]},"reference":[{"issue":"2","key":"1909_CR1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","volume":"10","author":"F Martinon","year":"2002","unstructured":"Martinon F, Burns K, Tschopp J (2002) The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 10(2):417\u2013426","journal-title":"Mol Cell"},{"key":"1909_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/1750-1326-4-47","volume":"4","author":"TC Frank-Cannon","year":"2009","unstructured":"Frank-Cannon TC, Alto LT, McAlpine FE, Tansey MG (2009) Does neuroinflammation fan the flame in neurodegenerative diseases? Mol Neurodegener 4:47. https:\/\/doi.org\/10.1186\/1750-1326-4-47","journal-title":"Mol Neurodegener"},{"issue":"6","key":"1909_CR3","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","volume":"140","author":"CK Glass","year":"2010","unstructured":"Glass CK, Saijo K, Winner B, Marchetto MC, Gage FH (2010) Mechanisms underlying inflammation in neurodegeneration. Cell 140(6):918\u2013934. https:\/\/doi.org\/10.1016\/j.cell.2010.02.016","journal-title":"Cell"},{"issue":"7","key":"1909_CR4","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nri3705","volume":"14","author":"MT Heneka","year":"2014","unstructured":"Heneka MT, Kummer MP, Latz E (2014) Innate immune activation in neurodegenerative disease. Nat Rev Immunol 14(7):463\u2013477. https:\/\/doi.org\/10.1038\/nri3705","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"1909_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nri3452","volume":"13","author":"E Latz","year":"2013","unstructured":"Latz E, Xiao TS, Stutz A (2013) Activation and regulation of the inflammasomes. Nat Rev Immunol 13(6):397\u2013411. https:\/\/doi.org\/10.1038\/nri3452","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"1909_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1002\/glia.10256","volume":"43","author":"CC Bowman","year":"2003","unstructured":"Bowman CC, Rasley A, Tranguch SL, Marriott I (2003) Cultured astrocytes express toll-like receptors for bacterial products. Glia 43(3):281\u2013291. https:\/\/doi.org\/10.1002\/glia.10256","journal-title":"Glia"},{"key":"1909_CR7","doi-asserted-by":"publisher","first-page":"315","DOI":"10.3389\/fnins.2014.00315","volume":"8","author":"G Singhal","year":"2014","unstructured":"Singhal G, Jaehne EJ, Corrigan F, Toben C, Baune BT (2014) Inflammasomes in neuroinflammation and changes in brain function: a focused review. Front Neurosci 8:315. https:\/\/doi.org\/10.3389\/fnins.2014.00315","journal-title":"Front Neurosci"},{"issue":"4","key":"1909_CR8","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y, Shi W, Li F et al (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab 34(4):660\u2013667. https:\/\/doi.org\/10.1038\/jcbfm.2013.242","journal-title":"J Cereb Blood Flow Metab"},{"issue":"3","key":"1909_CR9","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1172\/JCI65167","volume":"123","author":"N Deroide","year":"2013","unstructured":"Deroide N, Li X, Lerouet D, Van Vre E, Baker L, Harrison J, Poittevin M, Masters L et al (2013) MFGE8 inhibits inflammasome-induced IL-1beta production and limits postischemic cerebral injury. J Clin Invest 123(3):1176\u20131181. https:\/\/doi.org\/10.1172\/JCI65167","journal-title":"J Clin Invest"},{"issue":"2","key":"1909_CR10","doi-asserted-by":"publisher","first-page":"1082","DOI":"10.1007\/s12035-017-0394-9","volume":"55","author":"DY Fann","year":"2018","unstructured":"Fann DY, Lim YA, Cheng YL, Lok KZ, Chunduri P, Baik SH, Drummond GR, Dheen ST et al (2018) Evidence that NF-kappaB and MAPK signaling promotes NLRP inflammasome activation in neurons following ischemic stroke. Mol Neurobiol 55(2):1082\u20131096. https:\/\/doi.org\/10.1007\/s12035-017-0394-9","journal-title":"Mol Neurobiol"},{"issue":"2","key":"1909_CR11","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1007\/s12035-014-8766-x","volume":"51","author":"T Ishrat","year":"2015","unstructured":"Ishrat T, Mohamed IN, Pillai B, Soliman S, Fouda AY, Ergul A, El-Remessy AB, Fagan SC (2015) Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice. Mol Neurobiol 51(2):766\u2013778. https:\/\/doi.org\/10.1007\/s12035-014-8766-x","journal-title":"Mol Neurobiol"},{"issue":"10","key":"1909_CR12","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1177\/0271678X16662043","volume":"36","author":"N Lenart","year":"2016","unstructured":"Lenart N, Brough D, Denes A (2016) Inflammasomes link vascular disease with neuroinflammation and brain disorders. J Cereb Blood Flow Metab 36(10):1668\u20131685. https:\/\/doi.org\/10.1177\/0271678X16662043","journal-title":"J Cereb Blood Flow Metab"},{"issue":"13","key":"1909_CR13","doi-asserted-by":"publisher","first-page":"4050","DOI":"10.1073\/pnas.1419090112","volume":"112","author":"A Denes","year":"2015","unstructured":"Denes A, Coutts G, Lenart N, Cruickshank SM, Pelegrin P, Skinner J, Rothwell N, Allan SM et al (2015) AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3. Proc Natl Acad Sci U S A 112(13):4050\u20134055. https:\/\/doi.org\/10.1073\/pnas.1419090112","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"1909_CR14","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/nrn3638","volume":"15","author":"JG Walsh","year":"2014","unstructured":"Walsh JG, Muruve DA, Power C (2014) Inflammasomes in the CNS. Nat Rev Neurosci 15(2):84\u201397. https:\/\/doi.org\/10.1038\/nrn3638","journal-title":"Nat Rev Neurosci"},{"key":"1909_CR15","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.bbi.2018.09.001","volume":"75","author":"L Poh","year":"2019","unstructured":"Poh L, Kang SW, Baik SH, Ng GYQ, She DT, Balaganapathy P, Dheen ST, Magnus T et al (2019) Evidence that NLRC4 inflammasome mediates apoptotic and pyroptotic microglial death following ischemic stroke. Brain Behav Immun 75:34\u201347. https:\/\/doi.org\/10.1016\/j.bbi.2018.09.001","journal-title":"Brain Behav Immun"},{"issue":"4","key":"1909_CR16","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.arr.2013.09.004","volume":"12","author":"DY Fann","year":"2013","unstructured":"Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV (2013) Pathogenesis of acute stroke and the role of inflammasomes. Ageing Res Rev 12(4):941\u2013966. https:\/\/doi.org\/10.1016\/j.arr.2013.09.004","journal-title":"Ageing Res Rev"},{"issue":"5","key":"1909_CR17","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1159\/000439435","volume":"103","author":"L Lammerding","year":"2016","unstructured":"Lammerding L, Slowik A, Johann S, Beyer C, Zendedel A (2016) Poststroke inflammasome expression and regulation in the peri-infarct area by gonadal steroids after transient focal ischemia in the rat brain. Neuroendocrinology 103(5):460\u2013475. https:\/\/doi.org\/10.1159\/000439435","journal-title":"Neuroendocrinology"},{"key":"1909_CR18","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.jsbmb.2016.11.018","volume":"167","author":"R Herzog","year":"2017","unstructured":"Herzog R, Zendedel A, Lammerding L, Beyer C, Slowik A (2017) Impact of 17beta-estradiol and progesterone on inflammatory and apoptotic microRNA expression after ischemia in a rat model. J Steroid Biochem Mol Biol 167:126\u2013134. https:\/\/doi.org\/10.1016\/j.jsbmb.2016.11.018","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"6","key":"1909_CR19","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1084\/jem.20160462","volume":"214","author":"V Neudecker","year":"2017","unstructured":"Neudecker V, Haneklaus M, Jensen O, Khailova L, Masterson JC, Tye H, Biette K, Jedlicka P et al (2017) Myeloid-derived miR-223 regulates intestinal inflammation via repression of the NLRP3 inflammasome. J Exp Med 214(6):1737\u20131752. https:\/\/doi.org\/10.1084\/jem.20160462","journal-title":"J Exp Med"},{"issue":"3","key":"1909_CR20","doi-asserted-by":"publisher","first-page":"2429","DOI":"10.3892\/etm.2017.5667","volume":"15","author":"L Wan","year":"2018","unstructured":"Wan L, Yuan X, Liu M, Xue B (2018) miRNA-223-3p regulates NLRP3 to promote apoptosis and inhibit proliferation of hep3B cells. Exp Ther Med 15(3):2429\u20132435. https:\/\/doi.org\/10.3892\/etm.2017.5667","journal-title":"Exp Ther Med"},{"issue":"Pt 2","key":"1909_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1093\/brain\/awn109","volume":"132","author":"H Neumann","year":"2009","unstructured":"Neumann H, Kotter MR, Franklin RJ (2009) Debris clearance by microglia: an essential link between degeneration and regeneration. Brain 132(Pt 2):288\u2013295. https:\/\/doi.org\/10.1093\/brain\/awn109","journal-title":"Brain"},{"issue":"4","key":"1909_CR22","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.nurt.2010.07.005","volume":"7","author":"MA Yenari","year":"2010","unstructured":"Yenari MA, Kauppinen TM, Swanson RA (2010) Microglial activation in stroke: therapeutic targets. Neurotherapeutics 7(4):378\u2013391. https:\/\/doi.org\/10.1016\/j.nurt.2010.07.005","journal-title":"Neurotherapeutics"},{"key":"1909_CR23","doi-asserted-by":"publisher","first-page":"306","DOI":"10.1016\/j.bbi.2016.12.014","volume":"61","author":"C Dempsey","year":"2017","unstructured":"Dempsey C, Rubio Araiz A, Bryson KJ, Finucane O, Larkin C, Mills EL, Robertson AAB, Cooper MA et al (2017) Inhibiting the NLRP3 inflammasome with MCC950 promotes non-phlogistic clearance of amyloid-beta and cognitive function in APP\/PS1 mice. Brain Behav Immun 61:306\u2013316. https:\/\/doi.org\/10.1016\/j.bbi.2016.12.014","journal-title":"Brain Behav Immun"},{"issue":"3","key":"1909_CR24","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.4049\/jimmunol.1601745","volume":"198","author":"L Jin","year":"2017","unstructured":"Jin L, Batra S, Jeyaseelan S (2017) Deletion of Nlrp3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis. J Immunol 198(3):1253\u20131262. https:\/\/doi.org\/10.4049\/jimmunol.1601745","journal-title":"J Immunol"},{"issue":"6","key":"1909_CR25","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1038\/ni.2595","volume":"14","author":"A Sokolovska","year":"2013","unstructured":"Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK et al (2013) Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nat Immunol 14(6):543\u2013553. https:\/\/doi.org\/10.1038\/ni.2595","journal-title":"Nat Immunol"},{"issue":"2\u20133","key":"1909_CR26","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/0165-5728(90)90073-V","volume":"27","author":"E Blasi","year":"1990","unstructured":"Blasi E, Barluzzi R, Bocchini V, Mazzolla R, Bistoni F (1990) Immortalization of murine microglial cells by a v-raf\/v-myc carrying retrovirus. J Neuroimmunol 27(2\u20133):229\u2013237","journal-title":"J Neuroimmunol"},{"key":"1909_CR27","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.jsbmb.2014.02.018","volume":"146","author":"P Habib","year":"2015","unstructured":"Habib P, Beyer C (2015) Regulation of brain microglia by female gonadal steroids. J Steroid Biochem Mol Biol 146:3\u201314. https:\/\/doi.org\/10.1016\/j.jsbmb.2014.02.018","journal-title":"J Steroid Biochem Mol Biol"},{"key":"1909_CR28","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.jsbmb.2013.06.003","volume":"138","author":"P Habib","year":"2013","unstructured":"Habib P, Dreymueller D, Ludwig A, Beyer C, Dang J (2013) Sex steroid hormone-mediated functional regulation of microglia-like BV-2 cells during hypoxia. J Steroid Biochem Mol Biol 138:195\u2013205. https:\/\/doi.org\/10.1016\/j.jsbmb.2013.06.003","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"2","key":"1909_CR29","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/s12031-013-0137-y","volume":"52","author":"P Habib","year":"2014","unstructured":"Habib P, Slowik A, Zendedel A, Johann S, Dang J, Beyer C (2014) Regulation of hypoxia-induced inflammatory responses and M1-M2 phenotype switch of primary rat microglia by sex steroids. J Mol Neurosci 52(2):277\u2013285. https:\/\/doi.org\/10.1007\/s12031-013-0137-y","journal-title":"J Mol Neurosci"},{"issue":"4","key":"1909_CR30","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1111\/bph.13139","volume":"173","author":"R Orihuela","year":"2016","unstructured":"Orihuela R, McPherson CA, Harry GJ (2016) Microglial M1\/M2 polarization and metabolic states. Br J Pharmacol 173(4):649\u2013665. https:\/\/doi.org\/10.1111\/bph.13139","journal-title":"Br J Pharmacol"},{"issue":"3\u20134","key":"1909_CR31","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1159\/000362279","volume":"99","author":"P Habib","year":"2014","unstructured":"Habib P, Dang J, Slowik A, Victor M, Beyer C (2014) Hypoxia-induced gene expression of aquaporin-4, cyclooxygenase-2 and hypoxia-inducible factor 1alpha in rat cortical astroglia is inhibited by 17beta-estradiol and progesterone. Neuroendocrinology 99(3\u20134):156\u2013167. https:\/\/doi.org\/10.1159\/000362279","journal-title":"Neuroendocrinology"},{"key":"1909_CR32","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1186\/1471-2105-13-134","volume":"13","author":"J Ye","year":"2012","unstructured":"Ye J, Coulouris G, Zaretskaya I, Cutcutache I, Rozen S, Madden TL (2012) Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction. BMC Bioinformatics 13:134. https:\/\/doi.org\/10.1186\/1471-2105-13-134","journal-title":"BMC Bioinformatics"},{"key":"1909_CR33","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jsbmb.2018.05.003","volume":"183","author":"Alexander Slowik","year":"2018","unstructured":"Slowik A, Lammerding L, Zendedel A, Habib P, Beyer C (2018) Impact of steroid hormones E2 and P on the NLRP3\/ASC\/Casp1 axis in primary mouse astroglia and BV-2 cells after in vitro hypoxia. J Steroid Biochem Mol Biol. https:\/\/doi.org\/10.1016\/j.jsbmb.2018.05.003","journal-title":"The Journal of Steroid Biochemistry and Molecular Biology"},{"issue":"6","key":"1909_CR34","doi-asserted-by":"publisher","first-page":"3702","DOI":"10.3892\/or.2017.6048","volume":"38","author":"N Sugimoto","year":"2017","unstructured":"Sugimoto N, Ishibashi H, Nakamura H, Yachie A, Ohno-Shosaku T (2017) Hypoxia-induced inhibition of the endocannabinoid system in glioblastoma cells. Oncol Rep 38(6):3702\u20133708. https:\/\/doi.org\/10.3892\/or.2017.6048","journal-title":"Oncol Rep"},{"key":"1909_CR35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.pneurobio.2016.05.001","volume":"142","author":"XY Xiong","year":"2016","unstructured":"Xiong XY, Liu L, Yang QW (2016) Functions and mechanisms of microglia\/macrophages in neuroinflammation and neurogenesis after stroke. Prog Neurobiol 142:23\u201344. https:\/\/doi.org\/10.1016\/j.pneurobio.2016.05.001","journal-title":"Prog Neurobiol"},{"issue":"1","key":"1909_CR36","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","volume":"87","author":"JA Smith","year":"2012","unstructured":"Smith JA, Das A, Ray SK, Banik NL (2012) Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases. Brain Res Bull 87(1):10\u201320. https:\/\/doi.org\/10.1016\/j.brainresbull.2011.10.004","journal-title":"Brain Res Bull"},{"issue":"1","key":"1909_CR37","doi-asserted-by":"publisher","first-page":"8618","DOI":"10.1038\/s41598-018-26775-w","volume":"8","author":"AP Perera","year":"2018","unstructured":"Perera AP, Fernando R, Shinde T, Gundamaraju R, Southam B, Sohal SS, Robertson AAB, Schroder K et al (2018) MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice. Sci Rep 8(1):8618. https:\/\/doi.org\/10.1038\/s41598-018-26775-w","journal-title":"Sci Rep"},{"issue":"1","key":"1909_CR38","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1038\/s41598-018-24350-x","volume":"8","author":"S Ismael","year":"2018","unstructured":"Ismael S, Zhao L, Nasoohi S, Ishrat T (2018) Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Sci Rep 8(1):5971. https:\/\/doi.org\/10.1038\/s41598-018-24350-x","journal-title":"Sci Rep"},{"issue":"35","key":"1909_CR39","doi-asserted-by":"publisher","first-page":"14104","DOI":"10.1073\/pnas.0700506104","volume":"104","author":"TV Arumugam","year":"2007","unstructured":"Arumugam TV, Tang SC, Lathia JD, Cheng A, Mughal MR, Chigurupati S, Magnus T, Chan SL et al (2007) Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proc Natl Acad Sci U S A 104(35):14104\u201314109. https:\/\/doi.org\/10.1073\/pnas.0700506104","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1909_CR40","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.326","volume":"4","author":"DY Fann","year":"2013","unstructured":"Fann DY, Lee SY, Manzanero S, Tang SC, Gelderblom M, Chunduri P, Bernreuther C, Glatzel M et al (2013) Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. Cell Death Dis 4:e790. https:\/\/doi.org\/10.1038\/cddis.2013.326","journal-title":"Cell Death Dis"},{"issue":"5","key":"1909_CR41","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/ni.1864","volume":"11","author":"VA Rathinam","year":"2010","unstructured":"Rathinam VA, Jiang Z, Waggoner SN, Sharma S, Cole LE, Waggoner L, Vanaja SK, Monks BG et al (2010) The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 11(5):395\u2013402. https:\/\/doi.org\/10.1038\/ni.1864","journal-title":"Nat Immunol"},{"issue":"7366","key":"1909_CR42","doi-asserted-by":"publisher","first-page":"592","DOI":"10.1038\/nature10394","volume":"477","author":"EM Kofoed","year":"2011","unstructured":"Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477(7366):592\u2013595. https:\/\/doi.org\/10.1038\/nature10394","journal-title":"Nature"},{"issue":"9","key":"1909_CR43","doi-asserted-by":"publisher","first-page":"729","DOI":"10.2174\/1389557516666160321112512","volume":"16","author":"D Amantea","year":"2016","unstructured":"Amantea D, Russo R, Certo M, Rombola L, Adornetto A, Morrone LA, Corasaniti MT, Bagetta G (2016) Caspase-1-independent maturation of IL-1beta in ischemic brain injury: is there a role for gelatinases? Mini reviews in medicinal chemistry 16(9):729\u2013737","journal-title":"Mini reviews in medicinal chemistry"},{"issue":"6","key":"1909_CR44","doi-asserted-by":"publisher","first-page":"3331","DOI":"10.4049\/jimmunol.1004062","volume":"187","author":"S Provoost","year":"2011","unstructured":"Provoost S, Maes T, Pauwels NS, Vanden Berghe T, Vandenabeele P, Lambrecht BN, Joos GF, Tournoy KG (2011) NLRP3\/caspase-1-independent IL-1beta production mediates diesel exhaust particle-induced pulmonary inflammation. J Immunol 187(6):3331\u20133337. https:\/\/doi.org\/10.4049\/jimmunol.1004062","journal-title":"J Immunol"},{"issue":"4","key":"1909_CR45","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4049\/jimmunol.158.4.1818","volume":"158","author":"G Fantuzzi","year":"1997","unstructured":"Fantuzzi G, Ku G, Harding MW, Livingston DJ, Sipe JD, Kuida K, Flavell RA, Dinarello CA (1997) Response to local inflammation of IL-1 beta-converting enzyme- deficient mice. J Immunol 158(4):1818\u20131824","journal-title":"J Immunol"},{"issue":"9","key":"1909_CR46","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1084\/jem.187.9.1463","volume":"187","author":"R Horai","year":"1998","unstructured":"Horai R, Asano M, Sudo K, Kanuka H, Suzuki M, Nishihara M, Takahashi M, Iwakura Y (1998) Production of mice deficient in genes for interleukin (IL)-1alpha, IL-1beta, IL-1alpha\/beta, and IL-1 receptor antagonist shows that IL-1beta is crucial in turpentine-induced fever development and glucocorticoid secretion. J Exp Med 187(9):1463\u20131475","journal-title":"J Exp Med"},{"issue":"47","key":"1909_CR47","doi-asserted-by":"publisher","first-page":"23426","DOI":"10.1073\/pnas.1916318116","volume":"116","author":"MH Park","year":"2019","unstructured":"Park MH, Lee M, Nam G, Kim M, Kang J, Choi BJ, Jeong MS, Park KH et al (2019) N,N\u2032-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer\u2019s disease transgenic mice. Proc Natl Acad Sci U S A 116(47):23426\u201323436. https:\/\/doi.org\/10.1073\/pnas.1916318116","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1\u20132","key":"1909_CR48","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jneuroim.2013.04.016","volume":"260","author":"F Shi","year":"2013","unstructured":"Shi F, Yang Y, Kouadir M, Fu Y, Yang L, Zhou X, Yin X, Zhao D (2013) Inhibition of phagocytosis and lysosomal acidification suppresses neurotoxic prion peptide-induced NALP3 inflammasome activation in BV2 microglia. J Neuroimmunol 260(1\u20132):121\u2013125. https:\/\/doi.org\/10.1016\/j.jneuroim.2013.04.016","journal-title":"J Neuroimmunol"},{"key":"1909_CR49","doi-asserted-by":"publisher","first-page":"144","DOI":"10.3389\/fnmol.2018.00144","volume":"11","author":"E Janda","year":"2018","unstructured":"Janda E, Boi L, Carta AR (2018) Microglial phagocytosis and its regulation: a therapeutic target in Parkinson\u2019s disease? Front Mol Neurosci 11:144. https:\/\/doi.org\/10.3389\/fnmol.2018.00144","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"1909_CR50","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.cell.2017.07.023","volume":"170","author":"TK Ulland","year":"2017","unstructured":"Ulland TK, Song WM, Huang SC, Ulrich JD, Sergushichev A, Beatty WL, Loboda AA, Zhou Y et al (2017) TREM2 maintains microglial metabolic fitness in Alzheimer\u2019s disease. Cell 170(4):649\u2013663 e613. https:\/\/doi.org\/10.1016\/j.cell.2017.07.023","journal-title":"Cell"},{"key":"1909_CR51","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13024-015-0040-9","volume":"10","author":"MM Painter","year":"2015","unstructured":"Painter MM, Atagi Y, Liu CC, Rademakers R, Xu H, Fryer JD, Bu G (2015) TREM2 in CNS homeostasis and neurodegenerative disease. Mol Neurodegener 10:43. https:\/\/doi.org\/10.1186\/s13024-015-0040-9","journal-title":"Mol Neurodegener"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-01909-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s12035-020-01909-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-01909-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:12:24Z","timestamp":1695985944000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s12035-020-01909-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,1]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["1909"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-01909-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,1]]},"assertion":[{"value":"30 October 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 March 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}]}}