{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:00:42Z","timestamp":1785308442503,"version":"3.55.0"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701182"],"award-info":[{"award-number":["81701182"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671299"],"award-info":[{"award-number":["81671299"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of\u00a0Hunan Province","doi-asserted-by":"publisher","award":["2018JJ2648"],"award-info":[{"award-number":["2018JJ2648"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s12035-020-01968-5","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T04:07:31Z","timestamp":1592712451000},"page":"3712-3726","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Dynamic Change of Shanks Gene mRNA Expression and DNA Methylation in Epileptic Rat Model and Human Patients"],"prefix":"10.1007","volume":"57","author":[{"given":"Yujiao","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbiao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7175-1141","authenticated-orcid":false,"given":"Zhaohui","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"1968_CR1","doi-asserted-by":"publisher","first-page":"1353","DOI":"10.1007\/s10072-017-2974-x","volume":"38","author":"R Keller","year":"2017","unstructured":"Keller R, Basta R, Salerno L, Elia M (2017) Autism, epilepsy, and synaptopathies: a not rare association. Neurol Sci 38:1353\u20131361","journal-title":"Neurol Sci"},{"key":"1968_CR2","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/nature21678","volume":"543","author":"V Krishnan","year":"2017","unstructured":"Krishnan V, Stoppel DC, Nong Y, Johnson MA, Nadler MJS, Ozkaynak E, Teng BL, Nagakura I et al (2017) Autism gene Ube3a and seizures impair sociability by repressing VTA Cbln1. Nature 543:507\u2013512","journal-title":"Nature"},{"key":"1968_CR3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1038\/nature20414","volume":"539","author":"A Abeliovich","year":"2016","unstructured":"Abeliovich A, Gitler AD (2016) Defects in trafficking bridge Parkinson\u2019s disease pathology and genetics. Nature 539:207\u2013216","journal-title":"Nature"},{"key":"1968_CR4","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","volume":"25","author":"MV Lourenco","year":"2019","unstructured":"Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gon\u00e7alves RA, Clarke JR et al (2019) Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer\u2019s models. Nat Med 25:165\u2013175","journal-title":"Nat Med"},{"key":"1968_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1038\/nature13248","volume":"511","author":"T Karayannis","year":"2014","unstructured":"Karayannis T, Au E, Patel JC, Kruglikov I, Markx S, Delorme R, H\u00e9ron D, Salomon D et al (2014) Cntnap4 differentially contributes to GABAergic and dopaminergic synaptic transmission. Nature 511:236\u2013240","journal-title":"Nature"},{"key":"1968_CR6","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/nrn3937","volume":"16","author":"I Soltesz","year":"2015","unstructured":"Soltesz I, Alger BE, Kano M, Lee SH, Lovinger DM, Ohno-Shosaku T, Watanabe M (2015) Weeding out bad waves: towards selective cannabinoid circuit control in epilepsy. Nat Rev Neurosci 16:264\u2013277","journal-title":"Nat Rev Neurosci"},{"key":"1968_CR7","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1038\/mp.2017.245","volume":"23","author":"TM Khlebodarova","year":"2018","unstructured":"Khlebodarova TM, Kogai VV, Trifonova EA, Likhoshvai VA (2018) Dynamic landscape of the local translation at activated synapses. Mol Psychiatry 23:107\u2013114","journal-title":"Mol Psychiatry"},{"key":"1968_CR8","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.1038\/nn.3259","volume":"15","author":"SM Shin","year":"2012","unstructured":"Shin SM, Zhang N, Hansen J, Gerges NZ, Pak DTS, Sheng M, Lee SH (2012) GKAP orchestrates activity-dependent postsynaptic protein remodeling and homeostatic scaling. Nat Neurosci 15:1655\u20131666","journal-title":"Nat Neurosci"},{"key":"1968_CR9","doi-asserted-by":"publisher","first-page":"1025","DOI":"10.1016\/j.neuron.2013.07.050","volume":"80","author":"T Yuan","year":"2013","unstructured":"Yuan T, Mameli M, O'Connor EC, Dey PN, Verpelli C, Sala C, Perez-Otano I, L\u00fcscher C et al (2013) Expression of cocaine-evoked synaptic plasticity by GluN3A-containing NMDA receptors. Neuron 80:1025\u20131038","journal-title":"Neuron"},{"key":"1968_CR10","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/nrn.2016.183","volume":"18","author":"P Monteiro","year":"2017","unstructured":"Monteiro P, Feng G (2017) SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci 18:147\u2013157","journal-title":"Nat Rev Neurosci"},{"key":"1968_CR11","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1002\/aur.1925","volume":"11","author":"EL Berg","year":"2018","unstructured":"Berg EL, Copping NA, Rivera JK, Pride MC, Careaga M, Bauman MD, Berman RF, Lein PJ et al (2018) Developmental social communication deficits in the Shank3 rat model of Phelan-McDermid syndrome and autism spectrum disorder. Autism Res 11:587\u2013601","journal-title":"Autism Res"},{"key":"1968_CR12","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1002\/ajmg.b.32528","volume":"174","author":"A de Sena Cortabitarte","year":"2017","unstructured":"de Sena Cortabitarte A, Degenhardt F, Strohmaier J, Lang M, Weiss B, Roeth R, Giegling I, Heilmann-Heimbach S et al (2017) Investigation of SHANK3 in schizophrenia. Am J Med Genet Part B Neuropsychiatr Genet 174:390\u2013398","journal-title":"Am J Med Genet Part B Neuropsychiatr Genet"},{"key":"1968_CR13","doi-asserted-by":"publisher","first-page":"e76299","DOI":"10.1371\/journal.pone.0076299","volume":"8","author":"ZM Machnes","year":"2013","unstructured":"Machnes ZM, Huang TCT, Chang PKY, Gill R, Reist N, Dezsi G, Ozturk E, Charron F et al (2013) DNA methylation mediates persistent epileptiform activity in vitro and in vivo. PLoS One 8:e76299","journal-title":"PLoS One"},{"key":"1968_CR14","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1097\/NEN.0b013e31819ba737","volume":"68","author":"K Kobow","year":"2009","unstructured":"Kobow K, Jeske I, Hildebrandt M, Hauke J, Hahnen E, Buslei R, Buchfelder M, Weigel D et al (2009) Increased reelin promoter methylation is associated with granule cell dispersion in human temporal lobe epilepsy. J Neuropathol Exp Neurol 68:356\u2013364","journal-title":"J Neuropathol Exp Neurol"},{"issue":"Suppl 4","key":"1968_CR15","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1111\/j.1528-1167.2011.03145.x","volume":"52","author":"K Kobow","year":"2011","unstructured":"Kobow K, Bl\u00fcmcke I (2011) The methylation hypothesis: do epigenetic chromatin modifications play a role in epileptogenesis? Epilepsia 52(Suppl 4):15\u201319","journal-title":"Epilepsia"},{"key":"1968_CR16","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/s41583-019-0121-9","volume":"20","author":"RR Campbell","year":"2019","unstructured":"Campbell RR, Wood MA (2019) How the epigenome integrates information and reshapes the synapse. Nat Rev Neurosci 20:133\u2013147","journal-title":"Nat Rev Neurosci"},{"key":"1968_CR17","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1111\/j.1471-4159.2007.04539.x","volume":"101","author":"S Beri","year":"2007","unstructured":"Beri S, Tonna N, Menozzi G, Bonaglia MC, Sala C, Giorda R (2007) DNA methylation regulates tissue-specific expression of Shank3. J Neurochem 101:1380\u20131391","journal-title":"J Neurochem"},{"key":"1968_CR18","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.seizure.2019.04.010","volume":"69","author":"ZH Luo","year":"2019","unstructured":"Luo ZH, Walid A A, Xie Y, Long H, Xiao W, Xu L, Fu Y, Feng L et al (2019) Construction and analysis of a dysregulated lncRNA-associated ceRNA network in a rat model of temporal lobe epilepsy. Seizure 69:105\u2013114","journal-title":"Seizure"},{"key":"1968_CR19","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1124\/mol.115.098202","volume":"88","author":"Y Fu","year":"2015","unstructured":"Fu Y, Yang MS, Jiang J, Ganesh T, Joe E, Dingledine R (2015) EP2 receptor signaling regulates microglia death. Mol Pharmacol 88:161\u2013170","journal-title":"Mol Pharmacol"},{"key":"1968_CR20","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s12035-016-0353-x","volume":"55","author":"W Xiao","year":"2018","unstructured":"Xiao W, Cao Y, Long H, Luo Z, Li S, Deng N, Wang J, Lu X et al (2018) Genome-wide DNA methylation patterns analysis of noncoding RNAs in temporal lobe epilepsy patients. Mol Neurobiol 55:793\u2013803","journal-title":"Mol Neurobiol"},{"key":"1968_CR21","doi-asserted-by":"publisher","first-page":"43810","DOI":"10.1038\/srep43810","volume":"7","author":"H-Y Long","year":"2017","unstructured":"Long H-Y, Feng L, Kang J, Luo ZH, Xiao WB, Long LL, Yan XX, Zhou L et al (2017) Blood DNA methylation pattern is altered in mesial temporal lobe epilepsy. Sci Rep 7:43810","journal-title":"Sci Rep"},{"key":"1968_CR22","doi-asserted-by":"publisher","first-page":"7022","DOI":"10.1007\/s12035-019-1584-4","volume":"56","author":"W Xiao","year":"2019","unstructured":"Xiao W, Wu Y, Wang J, Luo Z, Long L, Deng N, Ning S, Zeng Y et al (2019) Network and pathway-based analysis of single-nucleotide polymorphism of miRNA in temporal lobe epilepsy. Mol Neurobiol 56:7022\u20137031","journal-title":"Mol Neurobiol"},{"key":"1968_CR23","doi-asserted-by":"publisher","first-page":"1203","DOI":"10.1111\/j.1471-4159.2006.03831.x","volume":"97","author":"S Uchino","year":"2006","unstructured":"Uchino S, Wada H, Honda S, Nakamura Y, Ondo Y, Uchiyama T, Tsutsumi M, Suzuki E et al (2006) Direct interaction of post-synaptic density-95\/Dlg\/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor. J Neurochem 97:1203\u20131214","journal-title":"J Neurochem"},{"issue":"Suppl 1","key":"1968_CR24","doi-asserted-by":"publisher","first-page":"S65","DOI":"10.1016\/S0140-6736(15)60380-4","volume":"385","author":"K Marwick","year":"2015","unstructured":"Marwick K, Skehel P, Hardingham G, Wyllie D (2015) Effect of a GRIN2A de novo mutation associated with epilepsy and intellectual disability on NMDA receptor currents and Mg(2+) block in cultured primary cortical neurons. Lancet Lond Engl 385(Suppl 1):S65","journal-title":"Lancet Lond Engl"},{"key":"1968_CR25","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1016\/j.ajhg.2016.07.013","volume":"99","author":"D Li","year":"2016","unstructured":"Li D, Yuan H, Ortiz-Gonzalez XR, Marsh ED, Tian L, McCormick EM, Kosobucki GJ, Chen W et al (2016) GRIN2D recurrent de novo dominant mutation causes a severe epileptic encephalopathy treatable with NMDA receptor channel blockers. Am J Hum Genet 99:802\u2013816","journal-title":"Am J Hum Genet"},{"key":"1968_CR26","doi-asserted-by":"publisher","first-page":"45540","DOI":"10.1038\/srep45540","volume":"7","author":"HA Rothan","year":"2017","unstructured":"Rothan HA, Amini E, Faraj FL, Golpich M, Teoh TC, Gholami K, Yusof R (2017) NMDA receptor antagonism with novel indolyl, 2-(1,1-dimethyl-1,3-dihydro-benzo[e]indol-2-ylidene)-malonaldehyde, reduces seizures duration in a rat model of epilepsy. Sci Rep 7:45540","journal-title":"Sci Rep"},{"key":"1968_CR27","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/brain\/awv325","volume":"139","author":"P Chang","year":"2016","unstructured":"Chang P, Augustin K, Boddum K, Williams S, Sun M, Terschak JA, Hardege JD, Chen PE et al (2016) Seizure control by decanoic acid through direct AMPA receptor inhibition. Brain J Neurol 139:431\u2013443","journal-title":"Brain J Neurol"},{"key":"1968_CR28","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/j.neuron.2016.08.012","volume":"91","author":"MV Yelshanskaya","year":"2016","unstructured":"Yelshanskaya MV, Singh AK, Sampson JM, Narangoda C, Kurnikova M, Sobolevsky AI (2016) Structural bases of noncompetitive inhibition of AMPA-subtype Ionotropic glutamate receptors by antiepileptic drugs. Neuron 91:1305\u20131315","journal-title":"Neuron"},{"key":"1968_CR29","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nature09965","volume":"472","author":"J Pe\u00e7a","year":"2011","unstructured":"Pe\u00e7a J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, Lascola CD, Fu Z et al (2011) Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature 472:437\u2013442","journal-title":"Nature"},{"key":"1968_CR30","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature16971","volume":"530","author":"Y Mei","year":"2016","unstructured":"Mei Y, Monteiro P, Zhou Y, Kim JA, Gao X, Fu Z, Feng G (2016) Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature 530:481\u2013484","journal-title":"Nature"},{"key":"1968_CR31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.neuron.2015.11.023","volume":"89","author":"Y Zhou","year":"2016","unstructured":"Zhou Y, Kaiser T, Monteiro P, Zhang X, van der Goes MS, Wang D, Barak B, Zeng M et al (2016) Mice with Shank3 mutations associated with ASD and schizophrenia display both shared and distinct defects. Neuron 89:147\u2013162","journal-title":"Neuron"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-01968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-020-01968-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-01968-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,20]],"date-time":"2021-06-20T23:37:10Z","timestamp":1624232230000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-020-01968-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,21]]},"references-count":31,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["1968"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-01968-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,21]]},"assertion":[{"value":"9 March 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All procedures were followed in accordance with the ethical standards of the responsible committee on animal and human experimentation (the Ethics Review Committee of Xiangya Hospital, numbers 201603296 and 201603297) and with the Helsinki Declaration of 1964 and later versions.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}