{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:59:44Z","timestamp":1790366384223,"version":"4.1.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T00:00:00Z","timestamp":1594857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology , Ministry of Science and Technology","doi-asserted-by":"publisher","award":["DBT\/IC-2\/Indo-Brazil\/2016-19\/02"],"award-info":[{"award-number":["DBT\/IC-2\/Indo-Brazil\/2016-19\/02"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["405243\/2015-4"],"award-info":[{"award-number":["405243\/2015-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["307611\/2018\u20103"],"award-info":[{"award-number":["307611\/2018\u20103"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08028\u20101"],"award-info":[{"award-number":["2013\/08028\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/50880-4"],"award-info":[{"award-number":["2012\/50880-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/02293"],"award-info":[{"award-number":["2013\/02293"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006123","name":"Instituto Nacional de Ci\u00eancia e Tecnologia para o Controle das Intoxica\u00e7\u00f5es por Plantas","doi-asserted-by":"publisher","award":["573633\/2008\u20108"],"award-info":[{"award-number":["573633\/2008\u20108"]}],"id":[{"id":"10.13039\/501100006123","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FINEP\u2010CTC","award":["0108057900"],"award-info":[{"award-number":["0108057900"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1007\/s12035-020-02006-0","type":"journal-article","created":{"date-parts":[[2020,7,16]],"date-time":"2020-07-16T15:11:02Z","timestamp":1594912262000},"page":"4117-4133","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1L39R Linked Amyotrophic Lateral Sclerosis"],"prefix":"10.1007","volume":"57","author":[{"given":"Chetan Singh","family":"Rajpurohit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arquimedes","family":"Cheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyllo","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Ulrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oswaldo Keith","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayana","family":"Zatz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzair Ahmad","family":"Ansari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay Kumar","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7674-6242","authenticated-orcid":false,"given":"Aditya Bhushan","family":"Pant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,7,16]]},"reference":[{"key":"2006_CR1","doi-asserted-by":"crossref","unstructured":"Katz JS, Woolley SC, (2019) Amyotrophic lateral sclerosis, Physician's Field Guide to Neuropsychology, Springer, pp. 255\u2013265.","DOI":"10.1007\/978-1-4939-8722-1_15"},{"key":"2006_CR2","doi-asserted-by":"crossref","unstructured":"Pansarasa O, Bordoni M, Diamanti L, Sproviero D, Gagliardi S, Cereda C (2018) SOD1 in amyotrophic lateral sclerosis: \"ambivalent\" behavior connected to the disease. Int J Mol Sci 19(5)","DOI":"10.3390\/ijms19051345"},{"issue":"1","key":"2006_CR3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/mus.26289","volume":"59","author":"MS Lyon","year":"2019","unstructured":"Lyon MS, Wosiski-Kuhn M, Gillespie R, Caress J, Milligan C (2019) Inflammation, immunity, and amyotrophic lateral sclerosis: I. Etiol Pathol Muscle Nerve 59(1):10\u201322","journal-title":"Etiol Pathol Muscle Nerve"},{"key":"2006_CR4","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3389\/fneur.2019.00229","volume":"10","author":"RH Chipika","year":"2019","unstructured":"Chipika RH, Finegan E, Shing SLH, Hardiman O, Bede P (2019) Tracking a fast-moving disease: longitudinal markers, monitoring, and clinical trial endpoints in ALS. Front Neurol 10:229","journal-title":"Front Neurol"},{"issue":"2","key":"2006_CR5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/med.21528","volume":"39","author":"MK Jaiswal","year":"2019","unstructured":"Jaiswal MK (2019) Riluzole and edaravone: A tale of two amyotrophic lateral sclerosis drugs. Med Res Rev 39(2):733\u2013748","journal-title":"Med Res Rev"},{"issue":"3","key":"2006_CR6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/cge.13015","volume":"92","author":"ZJ Liu","year":"2017","unstructured":"Liu ZJ, Lin HX, Liu GL, Tao QQ, Ni W, Xiao BG, Wu ZY (2017) The investigation of genetic and clinical features in Chinese patients with juvenile amyotrophic lateral sclerosis. Clin Genet 92(3):267\u2013273","journal-title":"Clin Genet"},{"issue":"4","key":"2006_CR7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/jnnp.2010.218982","volume":"83","author":"P Mattsson","year":"2012","unstructured":"Mattsson P, L\u00f6nnstedt I, Nygren I, Askmark H (2012) Physical fitness, but not muscle strength, is a risk factor for death in amyotrophic lateral sclerosis at an early age. J Neurol Neurosurg Psychiatry 83(4):390\u2013394","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"2006_CR8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1007\/s00415-017-8719-1","volume":"265","author":"M \u00c5berg","year":"2018","unstructured":"\u00c5berg M, Nyberg J, Robertson J, Kuhn G, Schi\u00f6ler L, Nissbrandt H, Waern M, Tor\u00e9n K (2018) Risk factors in Swedish young men for amyotrophic lateral sclerosis in adulthood. J Neurol 265(3):460\u2013470","journal-title":"J Neurol"},{"issue":"5642","key":"2006_CR9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1126\/science.1086071","volume":"302","author":"A Clement","year":"2003","unstructured":"Clement A, Nguyen M, Roberts E, Garcia M, Boillee S, Rule M, McMahon A, Doucette W et al (2003) Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302(5642):113\u2013117","journal-title":"Science"},{"issue":"6","key":"2006_CR10","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.stem.2008.10.001","volume":"3","author":"MC Marchetto","year":"2008","unstructured":"Marchetto MC, Muotri AR, Mu Y, Smith AM, Cezar GG, Gage FH (2008) Non-cell-autonomous effect of human SOD1 G37R astrocytes on motor neurons derived from human embryonic stem cells. Cell Stem Cell 3(6):649\u2013657","journal-title":"Cell Stem Cell"},{"key":"2006_CR11","unstructured":"McAvoy KJ, (2019) Non-cell autonomous toxicity in Motor neuron disease: evidence and mechanisms of astrocyte-driven neurotoxicity in FUS-ALS, ETD collection for Thomas Jefferson University. AAI13425948"},{"issue":"8","key":"2006_CR12","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1016\/j.jmb.2019.12.035","volume":"432","author":"A Djajadikerta","year":"2019","unstructured":"Djajadikerta A, Keshri S, Pavel M, Prestil R, Ryan L, Rubinsztein DC (2019) Autophagy induction as a therapeutic strategy for neurodegenerative diseases. J Mol Biol 432(8):2799\u20132821","journal-title":"J Mol Biol"},{"key":"2006_CR13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.brainres.2009.01.041","volume":"1263","author":"K Vijayalakshmi","year":"2009","unstructured":"Vijayalakshmi K, Alladi PA, Sathyaprabha T, Subramaniam JR, Nalini A, Raju T (2009) Cerebrospinal fluid from sporadic amyotrophic lateral sclerosis patients induces degeneration of a cultured motor neuron cell line. Brain Res 1263:122\u2013133","journal-title":"Brain Res"},{"issue":"3","key":"2006_CR14","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.nbd.2010.12.005","volume":"41","author":"K Vijayalakshmi","year":"2011","unstructured":"Vijayalakshmi K, Alladi PA, Ghosh S, Prasanna V, Sagar B, Nalini A, Sathyaprabha T, Raju T (2011) Evidence of endoplasmic reticular stress in the spinal motor neurons exposed to CSF from sporadic amyotrophic lateral sclerosis patients. Neurobiol Dis 41(3):695\u2013705","journal-title":"Neurobiol Dis"},{"issue":"2","key":"2006_CR15","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1007\/s12035-018-1149-y","volume":"56","author":"R Sumitha","year":"2018","unstructured":"Sumitha R, Manjunatha VM, Sabitha RK, Alladi PA, Nalini A, Rao LT, Chandrasekhar Sagar BK, Steinbusch HWM et al (2018) Cerebrospinal fluid from patients with sporadic amyotrophic lateral sclerosis induces degeneration of motor neurons derived from human embryonic stem cells. Mol Neurobiol 56(2):1014\u20131034","journal-title":"Mol Neurobiol"},{"issue":"6","key":"2006_CR16","doi-asserted-by":"crossref","first-page":"969","DOI":"10.4103\/1673-5374.250571","volume":"14","author":"R Maimon","year":"2019","unstructured":"Maimon R, Perlson E (2019) Muscle secretion of toxic factors, regulated by miR126-5p, facilitates motor neuron degeneration in amyotrophic lateral sclerosis. Neural Regen Res 14(6):969\u2013970","journal-title":"Neural Regen Res"},{"issue":"10","key":"2006_CR17","doi-asserted-by":"crossref","first-page":"3744","DOI":"10.1074\/jbc.RA118.004825","volume":"294","author":"JM Silverman","year":"2019","unstructured":"Silverman JM, Christy D, Shyu CC, Moon KM, Fernando S, Gidden Z, Cowan CM, Ban Y et al (2019) CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)(G93A) ALS mice originate from astrocytes and neurons and carry misfolded SOD1. J Biol Chem 294(10):3744\u20133759","journal-title":"J Biol Chem"},{"issue":"13","key":"2006_CR18","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.1093\/nar\/29.13.2860","volume":"29","author":"NM Luscombe","year":"2001","unstructured":"Luscombe NM, Laskowski RA, Thornton JM (2001) Amino acid\u2013base interactions: a three-dimensional analysis of protein\u2013DNA interactions at an atomic level. Nucleic Acids Res 29(13):2860\u20132874","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2006_CR19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/ncb1589","volume":"9","author":"S Masui","year":"2007","unstructured":"Masui S, Nakatake Y, Toyooka Y, Shimosato D, Yagi R, Takahashi K, Okochi H, Okuda A et al (2007) Pluripotency governed by Sox2 via regulation of Oct3\/4 expression in mouse embryonic stem cells. Nat Cell Biol 9(6):625\u2013635","journal-title":"Nat Cell Biol"},{"issue":"12","key":"2006_CR20","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1002\/mrd.20525","volume":"73","author":"S He","year":"2006","unstructured":"He S, Pant D, Schiffmacher A, Bischoff S, Melican D, Gavin W, Keefer C (2006) Developmental expression of pluripotency determining factors in caprine embryos: novel pattern of NANOG protein localization in the nucleolus. Mol Reprod Dev 73(12):1512\u20131522","journal-title":"Mol Reprod Dev"},{"issue":"145","key":"2006_CR21","doi-asserted-by":"crossref","first-page":"145ra104","DOI":"10.1126\/scitranslmed.3004052","volume":"4","author":"N Egawa","year":"2012","unstructured":"Egawa N, Kitaoka S, Tsukita K, Naitoh M, Takahashi K, Yamamoto T, Adachi F, Kondo T et al (2012) Drug screening for ALS using patient-specific induced pluripotent stem cells. Sci Transl Med 4(145):145ra104","journal-title":"Sci Transl Med"},{"key":"2006_CR22","doi-asserted-by":"crossref","first-page":"101417","DOI":"10.1016\/j.scr.2019.101417","volume":"36","author":"J Ma","year":"2019","unstructured":"Ma J, Guo R, Song Y, Zhang J, Feng B, Amponsah AE, Kong D, He J et al (2019) Generation and characterization of a human induced pluripotent stem cell (iPSC) line (HEBHMUi001-A) from a sporadic Parkinson's disease patient. Stem Cell Res 36:101417","journal-title":"Stem Cell Res"},{"key":"2006_CR23","doi-asserted-by":"crossref","unstructured":"Leferink P, Dooves S, Hillen A, Watanabe K, Jacobs G, Gasparotto L, Cornelissen-Steijger P, van der Knaap M, Heine V, (2019) Human and mouse iPSC-derived astrocyte subtypes reveal vulnerability in vanishing white matter, bioRxiv 523233.","DOI":"10.1101\/523233"},{"issue":"2","key":"2006_CR24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/glia.22930","volume":"64","author":"DM Norden","year":"2016","unstructured":"Norden DM, Trojanowski PJ, Villanueva E, Navarro E, Godbout JP (2016) Sequential activation of microglia and astrocyte cytokine expression precedes increased iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia 64(2):300\u2013316","journal-title":"Glia"},{"key":"2006_CR25","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3389\/fneur.2019.00527","volume":"10","author":"J Huai","year":"2019","unstructured":"Huai J, Zhang Z (2019) Structural properties and interaction partners of familial ALS-associated SOD1 mutants. Front Neurol 10:527","journal-title":"Front Neurol"},{"issue":"11","key":"2006_CR26","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.1640108","volume":"22","author":"H Nishitoh","year":"2008","unstructured":"Nishitoh H, Kadowaki H, Nagai A, Maruyama T, Yokota T, Fukutomi H, Noguchi T, Matsuzawa A et al (2008) ALS-linked mutant SOD1 induces ER stress-and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev 22(11):1451\u20131464","journal-title":"Genes Dev"},{"issue":"6","key":"2006_CR27","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00018-016-2379-7","volume":"74","author":"SZA Shah","year":"2017","unstructured":"Shah SZA, Hussain T, Zhao D, Yang L (2017) A central role for calcineurin in protein misfolding neurodegenerative diseases. Cell Mol Life Sci 74(6):1061\u20131074","journal-title":"Cell Mol Life Sci"},{"issue":"10","key":"2006_CR28","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1093\/emboj\/21.10.2343","volume":"21","author":"M Bonilla","year":"2002","unstructured":"Bonilla M, Nastase KK, Cunningham KW (2002) Essential role of calcineurin in response to endoplasmic reticulum stress. EMBO J 21(10):2343\u20132353","journal-title":"EMBO J"},{"issue":"9","key":"2006_CR29","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1080\/15548627.2019.1591672","volume":"15","author":"BL Baechler","year":"2019","unstructured":"Baechler BL, Bloemberg D, Quadrilatero J (2019) Mitophagy regulates mitochondrial network signaling, oxidative stress, and apoptosis during myoblast differentiation. Autophagy 15(9):1606\u20131619 1\u201314","journal-title":"Autophagy"},{"key":"2006_CR30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nbd.2019.05.011","volume":"129","author":"A Del Grosso","year":"2019","unstructured":"Del Grosso A, Angella L, Tonazzini I, Moscardini A, Giordano N, Caleo M, Rocchiccioli S, Cecchini M (2019) Dysregulated autophagy as a new aspect of the molecular pathogenesis of Krabbe disease. Neurobiol Dis 129:195\u2013207","journal-title":"Neurobiol Dis"},{"issue":"1","key":"2006_CR31","doi-asserted-by":"crossref","first-page":"15764","DOI":"10.1038\/s41598-018-33592-8","volume":"8","author":"W Stauffer","year":"2018","unstructured":"Stauffer W, Sheng H, Lim HN (2018) EzColocalization: An ImageJ plugin for visualizing and measuring colocalization in cells and organisms. Sci Rep 8(1):15764","journal-title":"Sci Rep"},{"key":"2006_CR32","first-page":"1639","volume":"19","author":"KE Keller","year":"2013","unstructured":"Keller KE, Yang YF, Sun YY, Sykes R, Acott TS, Wirtz MK (2013) Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. Mol Vis 19:1639\u20131655","journal-title":"Mol Vis"},{"issue":"9","key":"2006_CR33","doi-asserted-by":"crossref","first-page":"a016840","DOI":"10.1101\/cshperspect.a016840","volume":"6","author":"JP Luzio","year":"2014","unstructured":"Luzio JP, Hackmann Y, Dieckmann NM, Griffiths GM (2014) The biogenesis of lysosomes and lysosome-related organelles. Cold Spring Harb Perspect Biol 6(9):a016840","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"22","key":"2006_CR34","doi-asserted-by":"crossref","first-page":"15699","DOI":"10.1074\/jbc.M112.425066","volume":"288","author":"M Basso","year":"2013","unstructured":"Basso M, Pozzi S, Tortarolo M, Fiordaliso F, Bisighini C, Pasetto L, Spaltro G, Lidonnici D et al (2013) Mutant copper-zinc superoxide dismutase (SOD1) induces protein secretion pathway alterations and exosome release in astrocytes implications for disease spreading and motor neuron pathology in amyotrophic lateral sclerosis. J Biol Chem 288(22):15699\u201315711","journal-title":"J Biol Chem"},{"issue":"4","key":"2006_CR35","doi-asserted-by":"crossref","first-page":"e92325","DOI":"10.1371\/journal.pone.0092325","volume":"9","author":"SS Choi","year":"2014","unstructured":"Choi SS, Lee HJ, Lim I, Satoh J-i, Kim SU (2014) Human astrocytes: secretome profiles of cytokines and chemokines. PLoS One 9(4):e92325","journal-title":"PLoS One"},{"key":"2006_CR36","doi-asserted-by":"crossref","first-page":"1809592","DOI":"10.1155\/2017\/1809592","volume":"2017","author":"L Chen","year":"2017","unstructured":"Chen L, Liu B (2017) Relationships between stress granules, oxidative stress, and neurodegenerative diseases. Oxidative Med Cell Longev 2017:1809592","journal-title":"Oxidative Med Cell Longev"},{"key":"2006_CR37","doi-asserted-by":"crossref","first-page":"44","DOI":"10.3389\/fncel.2016.00044","volume":"10","author":"BM Edens","year":"2016","unstructured":"Edens BM, Miller N, Ma YC (2016) Impaired autophagy and defective mitochondrial function: converging paths on the road to motor neuron degeneration. Front Cell Neurosci 10:44","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"2006_CR38","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1159\/000453200","volume":"40","author":"Y Kang","year":"2016","unstructured":"Kang Y, Liu J, Song B, Feng X, Ou L, Wei L, Lai X, Shao L (2016) Potential links between cytoskeletal disturbances and electroneurophysiological dysfunctions induced in the central nervous system by inorganic nanoparticles. Cell Physiol Biochem 40(6):1487\u20131505","journal-title":"Cell Physiol Biochem"},{"issue":"4","key":"2006_CR39","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1089\/neu.2016.4477","volume":"34","author":"GB Effgen","year":"2017","unstructured":"Effgen GB, Morrison B III (2017) Electrophysiological and pathological characterization of the period of heightened vulnerability to repetitive injury in an in vitro stretch model. J Neurotrauma 34(4):914\u2013924","journal-title":"J Neurotrauma"},{"issue":"1750","key":"2006_CR40","doi-asserted-by":"crossref","first-page":"20170214","DOI":"10.1098\/rstb.2017.0214","volume":"373","author":"SF McComish","year":"2018","unstructured":"McComish SF, Caldwell MA (2018) Generation of defined neural populations from pluripotent stem cells. Philos Trans R Soc B: Biol Sci 373(1750):20170214","journal-title":"Philos Trans R Soc B: Biol Sci"},{"issue":"3","key":"2006_CR41","doi-asserted-by":"crossref","first-page":"9a","DOI":"10.1016\/j.bpj.2018.11.087","volume":"116","author":"B Bean","year":"2019","unstructured":"Bean B (2019) Context and complexity: how ionic conductances interact to control neuronal firing. Biophys J 116(3):9a\u201310a","journal-title":"Biophys J"},{"key":"2006_CR42","doi-asserted-by":"crossref","unstructured":"Allodi I, Nijssen J, Benitez JA, Schweingruber C, Fuchs A, Bonvicini G, Cao M, Kiehn O, E. Hedlund, (2019) Modeling motor neuron resilience in ALS using stem cells, bioRxiv 399659.","DOI":"10.1101\/399659"},{"issue":"3","key":"2006_CR43","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/stem.1293","volume":"31","author":"K Okita","year":"2013","unstructured":"Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, Goshima N, Yamanaka S (2013) An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. Stem Cells 31(3):458\u2013466","journal-title":"Stem Cells"},{"issue":"6","key":"2006_CR44","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/s41419-018-0737-0","volume":"9","author":"G Frati","year":"2018","unstructured":"Frati G, Luciani M, Meneghini V, De Cicco S, Stahlman M, Blomqvist M, Grossi S, Filocamo M et al (2018) Human iPSC-based models highlight defective glial and neuronal differentiation from neural progenitor cells in metachromatic leukodystrophy. Cell Death Dis 9(6):698","journal-title":"Cell Death Dis"},{"key":"2006_CR45","doi-asserted-by":"crossref","unstructured":"Meyer S, Worsdorfer P, Gunther K, Thier M, Edenhofer F, (2015) Derivation of adult human fibroblasts and their direct conversion into expandable neural progenitor cells, J Visual Exp (101):e52831.","DOI":"10.3791\/52831"},{"issue":"6","key":"2006_CR46","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1111\/cns.13107","volume":"25","author":"L Zhou","year":"2019","unstructured":"Zhou L, Li P, Chen N, Dai LF, Gao K, Liu YN, Shen L, Wang JM et al (2019) Modeling vanishing white matter disease with patient-derived induced pluripotent stem cells reveals astrocytic dysfunction. CNS Neurosci Ther 25(6):759\u2013771","journal-title":"CNS Neurosci Ther"},{"issue":"5","key":"2006_CR47","doi-asserted-by":"crossref","first-page":"233","DOI":"10.5607\/en.2016.25.5.233","volume":"25","author":"J Lee","year":"2016","unstructured":"Lee J, Hyeon SJ, Im H, Ryu H, Kim Y, Ryu H (2016) Astrocytes and microglia as non-cell autonomous players in the pathogenesis of ALS. Exp Neurobiol 25(5):233\u2013240","journal-title":"Exp Neurobiol"},{"key":"2006_CR48","doi-asserted-by":"crossref","unstructured":"Fernandes N, Eshleman N, Buchan JR, (2018), Stress granules and ALS: a case of causation or correlation?, RNA metabolism in neurodegenerative diseases, Springer pp. 173\u2013212.","DOI":"10.1007\/978-3-319-89689-2_7"},{"issue":"3","key":"2006_CR49","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/1061186X.2018.1523415","volume":"27","author":"C-H Zhang","year":"2019","unstructured":"Zhang C-H, Wang J-X, Cai M-L, Shao R, Liu H, Zhao W-L (2019) The roles and mechanisms of G3BP1 in tumour promotion. J Drug Target 27(3):300\u2013305","journal-title":"J Drug Target"},{"issue":"17","key":"2006_CR50","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1007\/s00018-018-2854-4","volume":"75","author":"CG Chung","year":"2018","unstructured":"Chung CG, Lee H, Lee SB (2018) Mechanisms of protein toxicity in neurodegenerative diseases. Cell Mol Life Sci 75(17):3159\u20133180","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"2006_CR51","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00401-016-1601-x","volume":"132","author":"J Gal","year":"2016","unstructured":"Gal J, Kuang L, Barnett KR, Zhu BZ, Shissler SC, Korotkov KV, Hayward LJ, Kasarskis EJ et al (2016) ALS mutant SOD1 interacts with G3BP1 and affects stress granule dynamics. Acta Neuropathol 132(4):563\u2013576","journal-title":"Acta Neuropathol"},{"issue":"Pt B","key":"2006_CR52","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.brainres.2016.05.022","volume":"1649","author":"Z Monahan","year":"2016","unstructured":"Monahan Z, Shewmaker F, Pandey UB (2016) Stress granules at the intersection of autophagy and ALS. Brain Res 1649(Pt B):189\u2013200","journal-title":"Brain Res"},{"key":"2006_CR53","doi-asserted-by":"crossref","unstructured":"Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, Luo J, Lee JK, Liang C, Chen JF, (2019) C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis, Autophagy 1\u201316.","DOI":"10.1080\/15548627.2019.1703353"},{"issue":"3","key":"2006_CR54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.neulet.2006.07.044","volume":"406","author":"YK Oh","year":"2006","unstructured":"Oh YK, Shin KS, Kang SJ (2006) AIF translocates to the nucleus in the spinal motor neurons in a mouse model of ALS. Neurosci Lett 406(3):205\u2013210","journal-title":"Neurosci Lett"},{"issue":"2","key":"2006_CR55","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1111\/bpa.12353","volume":"26","author":"M Myszczynska","year":"2016","unstructured":"Myszczynska M, Ferraiuolo L (2016) New in vitro models to study amyotrophic lateral sclerosis. Brain Pathol 26(2):258\u2013265","journal-title":"Brain Pathol"},{"issue":"6","key":"2006_CR56","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.stem.2008.09.017","volume":"3","author":"FP Di Giorgio","year":"2008","unstructured":"Di Giorgio FP, Boulting GL, Bobrowicz S, Eggan KC (2008) Human embryonic stem cell-derived motor neurons are sensitive to the toxic effect of glial cells carrying an ALS-causing mutation. Cell Stem Cell 3(6):637\u2013648","journal-title":"Cell Stem Cell"},{"issue":"1","key":"2006_CR57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/s13041-017-0300-4","volume":"10","author":"M Madill","year":"2017","unstructured":"Madill M, McDonagh K, Ma J, Vajda A, McLoughlin P, O'Brien T, Hardiman O, Shen S (2017) Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms. Molecular Brain 10(1):22","journal-title":"Molecular Brain"},{"issue":"2","key":"2006_CR58","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.stemcr.2018.12.011","volume":"12","author":"A di Domenico","year":"2019","unstructured":"di Domenico A, Carola G, Calatayud C, Pons-Espinal M, Munoz JP, Richaud-Patin Y, Fernandez-Carasa I, Gut M et al (2019) Patient-specific iPSC-derived astrocytes contribute to non-cell-autonomous neurodegeneration in Parkinson's disease. Stem Cell Reports 12(2):213\u2013229","journal-title":"Stem Cell Reports"},{"issue":"11","key":"2006_CR59","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1038\/nprot.2012.130","volume":"7","author":"J Beers","year":"2012","unstructured":"Beers J, Gulbranson DR, George N, Siniscalchi LI, Jones J, Thomson JA, Chen G (2012) Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions. Nat Protoc 7(11):2029\u20132040","journal-title":"Nat Protoc"},{"issue":"11","key":"2006_CR60","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1038\/nprot.2011.405","volume":"6","author":"R Krencik","year":"2011","unstructured":"Krencik R, Zhang S-C (2011) Directed differentiation of functional astroglial subtypes from human pluripotent stem cells. Nat Protoc 6(11):1710\u20131717","journal-title":"Nat Protoc"},{"issue":"9","key":"2006_CR61","doi-asserted-by":"crossref","first-page":"4335","DOI":"10.1073\/pnas.0910012107","volume":"107","author":"B-Y Hu","year":"2010","unstructured":"Hu B-Y, Weick JP, Yu J, Ma L-X, Zhang X-Q, Thomson JA, Zhang S-C (2010) Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency. Proc Natl Acad Sci 107(9):4335\u20134340","journal-title":"Proc Natl Acad Sci"},{"issue":"10","key":"2006_CR62","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/nprot.2012.116","volume":"7","author":"Y Shi","year":"2012","unstructured":"Shi Y, Kirwan P, Livesey FJ (2012) Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks. Nat Protoc 7(10):1836\u20131846","journal-title":"Nat Protoc"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02006-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-020-02006-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02006-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,10]],"date-time":"2024-08-10T05:12:50Z","timestamp":1723266770000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-020-02006-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,16]]},"references-count":62,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["2006"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-02006-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,16]]},"assertion":[{"value":"3 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 June 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 July 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"All the authors have gone through the contents of the manuscript and given their consent to publish. There is no conflict of interest among the authors of this manuscript for scientific contents, financial aspects and otherwise.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}