{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:24:57Z","timestamp":1790745897691,"version":"4.1.0"},"reference-count":128,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T00:00:00Z","timestamp":1597968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R35GM118337"],"award-info":[{"award-number":["R35GM118337"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s12035-020-02075-1","type":"journal-article","created":{"date-parts":[[2020,8,21]],"date-time":"2020-08-21T19:07:07Z","timestamp":1598036827000},"page":"5000-5010","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Potential Role of Extracellular CIRP in Alcohol-Induced Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"57","author":[{"given":"Archna","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1557-0394","authenticated-orcid":false,"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,8,21]]},"reference":[{"key":"2075_CR1","doi-asserted-by":"publisher","unstructured":"2020 Alzheimer's disease facts and figures (2020). 16 (3):391\u2013460. https:\/\/doi.org\/10.1002\/alz.12068","DOI":"10.1002\/alz.12068"},{"issue":"1","key":"2075_CR2","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","volume":"14","author":"MA DeTure","year":"2019","unstructured":"DeTure MA, Dickson DW (2019) The neuropathological diagnosis of Alzheimer\u2019s disease. Mol Neurodegener 14(1):32. https:\/\/doi.org\/10.1186\/s13024-019-0333-5","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2075_CR3","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1159\/000464422","volume":"24","author":"A Sanabria-Castro","year":"2017","unstructured":"Sanabria-Castro A, Alvarado-Echeverr\u00eda I, Monge-Bonilla C (2017) Molecular pathogenesis of Alzheimer's disease: an update. Ann Neurosci 24(1):46\u201354. https:\/\/doi.org\/10.1159\/000464422","journal-title":"Ann Neurosci"},{"issue":"1","key":"2075_CR4","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.stem.2019.06.001","volume":"25","author":"SH Choi","year":"2019","unstructured":"Choi SH, Tanzi RE (2019) Is Alzheimer's disease a neurogenesis disorder? Cell Stem Cell 25(1):7\u20138. https:\/\/doi.org\/10.1016\/j.stem.2019.06.001","journal-title":"Cell Stem Cell"},{"issue":"10","key":"2075_CR5","doi-asserted-by":"publisher","first-page":"175","DOI":"10.21037\/atm.2018.04.23","volume":"6","author":"YL Gao","year":"2018","unstructured":"Gao YL, Wang N, Sun FR, Cao XP, Zhang W, Yu JT (2018) Tau in neurodegenerative disease. Ann Translat Med 6(10):175. https:\/\/doi.org\/10.21037\/atm.2018.04.23","journal-title":"Ann Translat Med"},{"issue":"7","key":"2075_CR6","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/s11910-019-0962-7","volume":"19","author":"YT Wang","year":"2019","unstructured":"Wang YT, Edison P (2019) Tau imaging in neurodegenerative diseases using positron emission tomography. Current neurology and neuroscience reports 19(7):45. https:\/\/doi.org\/10.1007\/s11910-019-0962-7","journal-title":"Current neurology and neuroscience reports"},{"issue":"4","key":"2075_CR7","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.3233\/jad-180303","volume":"65","author":"FF de Oliveira","year":"2018","unstructured":"de Oliveira FF, de Almeida SS, Chen ES, Smith MC, Naffah-Mazzacoratti MDG, Bertolucci PHF (2018) Lifetime risk factors for functional and cognitive outcomes in patients with Alzheimer's disease. J Alzheim Diseas JAD 65(4):1283\u20131299. https:\/\/doi.org\/10.3233\/jad-180303","journal-title":"J Alzheim Diseas JAD"},{"key":"2075_CR8","doi-asserted-by":"publisher","first-page":"146","DOI":"10.3389\/fnagi.2019.00146","volume":"11","author":"GA Edwards Iii","year":"2019","unstructured":"Edwards Iii GA, Gamez N, Escobedo G Jr, Calderon O, Moreno-Gonzalez I (2019) Modifiable risk factors for Alzheimer's disease. Front Aging Neurosci 11:146. https:\/\/doi.org\/10.3389\/fnagi.2019.00146","journal-title":"Front Aging Neurosci"},{"key":"2075_CR9","doi-asserted-by":"publisher","first-page":"j2353","DOI":"10.1136\/bmj.j2353","volume":"357","author":"A Topiwala","year":"2017","unstructured":"Topiwala A, Allan CL, Valkanova V, Zsoldos E, Filippini N, Sexton C, Mahmood A, Fooks P et al (2017) Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: Longitudinal cohort study. BMJ (Clinical research ed) 357:j2353. https:\/\/doi.org\/10.1136\/bmj.j2353","journal-title":"BMJ (Clinical research ed)"},{"key":"2075_CR10","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.comppsych.2017.07.003","volume":"78","author":"H Xue","year":"2017","unstructured":"Xue H, Sun Q, Liu L, Zhou L, Liang R, He R, Yu H (2017) Risk factors of transition from mild cognitive impairment to Alzheimer's disease and death: a cohort study. Compr Psychiatry 78:91\u201397. https:\/\/doi.org\/10.1016\/j.comppsych.2017.07.003","journal-title":"Compr Psychiatry"},{"issue":"1","key":"2075_CR11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s10654-017-0225-3","volume":"32","author":"W Xu","year":"2017","unstructured":"Xu W, Wang H, Wan Y, Tan C, Li J, Tan L, Yu JT (2017) Alcohol consumption and dementia risk: a dose-response meta-analysis of prospective studies. Eur J Epidemiol 32(1):31\u201342. https:\/\/doi.org\/10.1007\/s10654-017-0225-3","journal-title":"Eur J Epidemiol"},{"issue":"2","key":"2075_CR12","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jalz.2019.09.086","volume":"16","author":"SJ Andrews","year":"2020","unstructured":"Andrews SJ, Goate A, Anstey KJ (2020) Association between alcohol consumption and Alzheimer's disease: a Mendelian randomization study. Alzheimer's & dementia : the journal of the Alzheimer's Association 16(2):345\u2013353. https:\/\/doi.org\/10.1016\/j.jalz.2019.09.086","journal-title":"Alzheimer's & dementia : the journal of the Alzheimer's Association"},{"issue":"12","key":"2075_CR13","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.2174\/1567205013666160603005035","volume":"13","author":"D Heymann","year":"2016","unstructured":"Heymann D, Stern Y, Cosentino S, Tatarina-Nulman O, Dorrejo JN, Gu Y (2016) The association between alcohol use and the progression of Alzheimer's disease. Curr Alzheimer Res 13(12):1356\u20131362. https:\/\/doi.org\/10.2174\/1567205013666160603005035","journal-title":"Curr Alzheimer Res"},{"issue":"3","key":"2075_CR14","doi-asserted-by":"publisher","first-page":"e124","DOI":"10.1016\/s2468-2667(18)30022-7","volume":"3","author":"M Schwarzinger","year":"2018","unstructured":"Schwarzinger M, Pollock BG, Hasan OSM, Dufouil C, Rehm J (2018) Contribution of alcohol use disorders to the burden of dementia in France 2008-13: a nationwide retrospective cohort study. Lancet Public Health 3(3):e124\u2013e132. https:\/\/doi.org\/10.1016\/s2468-2667(18)30022-7","journal-title":"Lancet Public Health"},{"key":"2075_CR15","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neuroscience.2017.08.013","volume":"361","author":"GM Fernandez","year":"2017","unstructured":"Fernandez GM, Savage LM (2017) Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex. Neuroscience 361:129\u2013143. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.08.013","journal-title":"Neuroscience"},{"issue":"10","key":"2075_CR16","doi-asserted-by":"publisher","first-page":"e0204500","DOI":"10.1371\/journal.pone.0204500","volume":"13","author":"RP Vetreno","year":"2018","unstructured":"Vetreno RP, Crews FT (2018) Adolescent binge ethanol-induced loss of basal forebrain cholinergic neurons and neuroimmune activation are prevented by exercise and indomethacin. PLoS One 13(10):e0204500. https:\/\/doi.org\/10.1371\/journal.pone.0204500","journal-title":"PLoS One"},{"key":"2075_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.alcohol.2019.11.002","volume":"85","author":"WJ Matloff","year":"2019","unstructured":"Matloff WJ, Zhao L, Ning K, Conti DV, Toga AW (2019) Interaction effect of alcohol consumption and Alzheimer disease polygenic risk score on the brain cortical thickness of cognitively normal subjects. Alcohol (Fayetteville, NY) 85:1\u201312. https:\/\/doi.org\/10.1016\/j.alcohol.2019.11.002","journal-title":"Alcohol (Fayetteville, NY)"},{"issue":"2","key":"2075_CR18","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1111\/psyg.12008","volume":"13","author":"A Toda","year":"2013","unstructured":"Toda A, Tagata Y, Nakada T, Komatsu M, Shibata N, Arai H (2013) Changes in mini-mental state examination score in Alzheimer's disease patients after stopping habitual drinking. Psychogeriatrics : the official journal of the Japanese Psychogeriatric Soc 13(2):94\u201398. https:\/\/doi.org\/10.1111\/psyg.12008","journal-title":"Psychogeriatrics : the official journal of the Japanese Psychogeriatric Soc"},{"key":"2075_CR19","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/bs.irn.2019.10.017","volume":"148","author":"JL Hoffman","year":"2019","unstructured":"Hoffman JL, Faccidomo S, Kim M, Taylor SM, Agoglia AE, May AM, Smith EN, Wong LC et al (2019) Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease. Int Rev Neurobiol 148:169\u2013230. https:\/\/doi.org\/10.1016\/bs.irn.2019.10.017","journal-title":"Int Rev Neurobiol"},{"issue":"1","key":"2075_CR20","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1002\/jlb.3mir1118-443r","volume":"106","author":"M Aziz","year":"2019","unstructured":"Aziz M, Brenner M, Wang P (2019) Extracellular CIRP (eCIRP) and inflammation. J Leukoc Biol 106(1):133\u2013146. https:\/\/doi.org\/10.1002\/jlb.3mir1118-443r","journal-title":"J Leukoc Biol"},{"issue":"9","key":"2075_CR21","doi-asserted-by":"publisher","first-page":"e0137721","DOI":"10.1371\/journal.pone.0137721","volume":"10","author":"Y Zhou","year":"2015","unstructured":"Zhou Y, Dong H, Zhong Y, Huang J, Lv J, Li J (2015) The cold-inducible RNA-binding protein (CIRP) level in peripheral blood predicts Sepsis outcome. PLoS One 10(9):e0137721\u2013e0137721. https:\/\/doi.org\/10.1371\/journal.pone.0137721","journal-title":"PLoS One"},{"key":"2075_CR22","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.cca.2017.06.002","volume":"471","author":"JD Gong","year":"2017","unstructured":"Gong JD, Qi XF, Zhang Y, Li HL (2017) Increased admission serum cold-inducible RNA-binding protein concentration is associated with prognosis of severe acute pancreatitis. Clinica chimica acta; international journal of clinical chemistry 471:135\u2013142. https:\/\/doi.org\/10.1016\/j.cca.2017.06.002","journal-title":"Clinica chimica acta; international journal of clinical chemistry"},{"issue":"1","key":"2075_CR23","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/1756-185x.12892","volume":"21","author":"IS Yoo","year":"2018","unstructured":"Yoo IS, Lee SY, Park CK, Lee JC, Kim Y, Yoo SJ, Shim SC, Choi YS et al (2018) Serum and synovial fluid concentrations of cold-inducible RNA-binding protein in patients with rheumatoid arthritis. Int J Rheum Dis 21(1):148\u2013154. https:\/\/doi.org\/10.1111\/1756-185x.12892","journal-title":"Int J Rheum Dis"},{"issue":"11","key":"2075_CR24","doi-asserted-by":"publisher","first-page":"e79430","DOI":"10.1371\/journal.pone.0079430","volume":"8","author":"SR Rajayer","year":"2013","unstructured":"Rajayer SR, Jacob A, Yang W-L, Zhou M, Chaung W, Wang P (2013) Cold-inducible RNA-binding protein is an important mediator of alcohol-induced brain inflammation. PLoS One 8(11):e79430\u2013e79430. https:\/\/doi.org\/10.1371\/journal.pone.0079430","journal-title":"PLoS One"},{"issue":"7","key":"2075_CR25","doi-asserted-by":"publisher","first-page":"2253","DOI":"10.1016\/j.bbagen.2014.02.027","volume":"1840","author":"M Zhou","year":"2014","unstructured":"Zhou M, Yang W-L, Ji Y, Qiang X, Wang P (2014) Cold-inducible RNA-binding protein mediates neuroinflammation in cerebral ischemia. Biochim Biophys Acta 1840(7):2253\u20132261. https:\/\/doi.org\/10.1016\/j.bbagen.2014.02.027","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2075_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13195-018-0453-0","volume":"11","author":"J Rehm","year":"2019","unstructured":"Rehm J, Hasan OSM, Black SE, Shield KD, Schwarzinger M (2019) Alcohol use and dementia: a systematic scoping review. Alzheimers Res Ther 11(1):1. https:\/\/doi.org\/10.1186\/s13195-018-0453-0","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"2075_CR27","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1080\/00952990.2016.1211667","volume":"43","author":"MA Monnig","year":"2017","unstructured":"Monnig MA (2017) Immune activation and neuroinflammation in alcohol use and HIV infection: evidence for shared mechanisms. The American journal of drug and alcohol abuse 43(1):7\u201323. https:\/\/doi.org\/10.1080\/00952990.2016.1211667","journal-title":"The American journal of drug and alcohol abuse"},{"key":"2075_CR28","doi-asserted-by":"publisher","first-page":"628","DOI":"10.3389\/fnins.2018.00628","volume":"12","author":"YN Paudel","year":"2018","unstructured":"Paudel YN, Shaikh MF, Chakraborti A, Kumari Y, Aledo-Serrano \u00c1, Aleksovska K, Alvim MKM, Othman I (2018) HMGB1: a common biomarker and potential target for TBI, neuroinflammation, epilepsy, and cognitive dysfunction. Front Neurosci 12:628\u2013628. https:\/\/doi.org\/10.3389\/fnins.2018.00628","journal-title":"Front Neurosci"},{"issue":"2","key":"2075_CR29","first-page":"331","volume":"37","author":"FT Crews","year":"2015","unstructured":"Crews FT, Sarkar DK, Qin L, Zou J, Boyadjieva N, Vetreno RP (2015) Neuroimmune function and the consequences of alcohol exposure. Alcohol Res 37(2):331\u2013351","journal-title":"Alcohol Res"},{"issue":"1","key":"2075_CR30","doi-asserted-by":"publisher","first-page":"12110","DOI":"10.1038\/s41598-019-47039-1","volume":"9","author":"HS Swartzwelder","year":"2019","unstructured":"Swartzwelder HS, Healey KL, Liu W, Dubester K, Miller KM, Crews FT (2019) Changes in neuroimmune and neuronal death markers after adolescent alcohol exposure in rats are reversed by donepezil. Sci Rep 9(1):12110\u201312110. https:\/\/doi.org\/10.1038\/s41598-019-47039-1","journal-title":"Sci Rep"},{"issue":"1","key":"2075_CR31","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12974-018-1184-7","volume":"15","author":"S Kalinin","year":"2018","unstructured":"Kalinin S, Gonz\u00e1lez-Prieto M, Scheiblich H, Lisi L, Kusumo H, Heneka MT, Madrigal JLM, Pandey SC et al (2018) Transcriptome analysis of alcohol-treated microglia reveals downregulation of beta amyloid phagocytosis. J Neuroinflammation 15(1):141. https:\/\/doi.org\/10.1186\/s12974-018-1184-7","journal-title":"J Neuroinflammation"},{"issue":"3","key":"2075_CR32","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1038\/s41588-018-0311-9","volume":"51","author":"IE Jansen","year":"2019","unstructured":"Jansen IE, Savage JE, Watanabe K, Bryois J, Williams DM, Steinberg S, Sealock J, Karlsson IK et al (2019) Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk. Nat Genet 51(3):404\u2013413. https:\/\/doi.org\/10.1038\/s41588-018-0311-9","journal-title":"Nat Genet"},{"issue":"9","key":"2075_CR33","doi-asserted-by":"publisher","first-page":"3240","DOI":"10.1172\/jci90606","volume":"127","author":"H Sarlus","year":"2017","unstructured":"Sarlus H, Heneka MT (2017) Microglia in Alzheimer's disease. J Clin Invest 127(9):3240\u20133249. https:\/\/doi.org\/10.1172\/jci90606","journal-title":"J Clin Invest"},{"issue":"4","key":"2075_CR34","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","volume":"49","author":"AR Simard","year":"2006","unstructured":"Simard AR, Soulet D, Gowing G, Julien JP, Rivest S (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49(4):489\u2013502. https:\/\/doi.org\/10.1016\/j.neuron.2006.01.022","journal-title":"Neuron"},{"issue":"6","key":"2075_CR35","doi-asserted-by":"publisher","first-page":"5006","DOI":"10.1007\/s12035-017-0703-3","volume":"55","author":"D Huang","year":"2018","unstructured":"Huang D, Yu M, Yang S, Lou D, Zhou W, Zheng L, Wang Z, Cai F et al (2018) Ethanol alters APP processing and aggravates Alzheimer-associated phenotypes. Mol Neurobiol 55(6):5006\u20135018. https:\/\/doi.org\/10.1007\/s12035-017-0703-3","journal-title":"Mol Neurobiol"},{"key":"2075_CR36","doi-asserted-by":"publisher","unstructured":"Hoekstra MM, Emmenegger Y, Hubbard J, Franken P (2019) Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation. eLife 8. https:\/\/doi.org\/10.7554\/eLife.43400","DOI":"10.7554\/eLife.43400"},{"key":"2075_CR37","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1007\/978-981-13-1244-1_3","volume":"1081","author":"Y Horii","year":"2018","unstructured":"Horii Y, Shiina T, Shimizu Y (2018) The mechanism enabling hibernation in mammals. Adv Exp Med Biol 1081:45\u201360. https:\/\/doi.org\/10.1007\/978-981-13-1244-1_3","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"2075_CR38","doi-asserted-by":"publisher","first-page":"3198","DOI":"10.1093\/nar\/gkx1317","volume":"46","author":"M Roilo","year":"2018","unstructured":"Roilo M, Kullmann MK, Hengst L (2018) Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1. Nucleic Acids Res 46(6):3198\u20133210. https:\/\/doi.org\/10.1093\/nar\/gkx1317","journal-title":"Nucleic Acids Res"},{"issue":"20","key":"2075_CR39","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1007\/s00018-016-2253-7","volume":"73","author":"X Zhu","year":"2016","unstructured":"Zhu X, B\u00fchrer C, Wellmann S (2016) Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold. Cellular and molecular life sciences : CMLS 73(20):3839\u20133859. https:\/\/doi.org\/10.1007\/s00018-016-2253-7","journal-title":"Cellular and molecular life sciences : CMLS"},{"issue":"4","key":"2075_CR40","doi-asserted-by":"publisher","first-page":"Fso246","DOI":"10.4155\/fsoa-2017-0077","volume":"3","author":"P Zhong","year":"2017","unstructured":"Zhong P, Huang H (2017) Recent progress in the research of cold-inducible RNA-binding protein. Future Sci OA 3(4):Fso246. https:\/\/doi.org\/10.4155\/fsoa-2017-0077","journal-title":"Future Sci OA"},{"issue":"11","key":"2075_CR41","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1038\/nm.3368","volume":"19","author":"X Qiang","year":"2013","unstructured":"Qiang X, Yang W-L, Wu R, Zhou M, Jacob A, Dong W, Kuncewitch M, Ji Y et al (2013) Cold-inducible RNA-binding protein (CIRP) triggers inflammatory responses in hemorrhagic shock and sepsis. Nat Med 19(11):1489\u20131495. https:\/\/doi.org\/10.1038\/nm.3368","journal-title":"Nat Med"},{"issue":"1","key":"2075_CR42","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/cmi.2016.43","volume":"15","author":"AC Bolognese","year":"2018","unstructured":"Bolognese AC, Sharma A, Yang W-L, Nicastro J, Coppa GF, Wang P (2018) Cold-inducible RNA-binding protein activates splenic T cells during sepsis in a TLR4-dependent manner. Cell Mol Immunol 15(1):38\u201347. https:\/\/doi.org\/10.1038\/cmi.2016.43","journal-title":"Cell Mol Immunol"},{"issue":"4","key":"2075_CR43","doi-asserted-by":"publisher","first-page":"e1409321","DOI":"10.1080\/2162402X.2017.1409321","volume":"7","author":"L Villanueva","year":"2017","unstructured":"Villanueva L, Silva L, Llopiz D, Ruiz M, Iglesias T, Lozano T, Casares N, Hervas-Stubbs S et al (2017) The toll like receptor 4 ligand cold-inducible RNA-binding protein as vaccination platform against cancer. Oncoimmunology 7(4):e1409321\u2013e1409321. https:\/\/doi.org\/10.1080\/2162402X.2017.1409321","journal-title":"Oncoimmunology"},{"issue":"1","key":"2075_CR44","doi-asserted-by":"publisher","first-page":"6252","DOI":"10.1038\/s41598-019-42762-1","volume":"9","author":"Y Ode","year":"2019","unstructured":"Ode Y, Aziz M, Jin H, Arif A, Nicastro JG, Wang P (2019) Cold-inducible RNA-binding protein induces neutrophil extracellular traps in the lungs during Sepsis. Sci Rep 9(1):6252\u20136252. https:\/\/doi.org\/10.1038\/s41598-019-42762-1","journal-title":"Sci Rep"},{"issue":"5","key":"2075_CR45","doi-asserted-by":"publisher","first-page":"e133715","DOI":"10.1172\/jci.insight.133715","volume":"5","author":"M Zhou","year":"2020","unstructured":"Zhou M, Aziz M, Denning N-L, Yen H-T, Ma G, Wang P (2020) Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. JCI insight 5(5):e133715. https:\/\/doi.org\/10.1172\/jci.insight.133715","journal-title":"JCI insight"},{"issue":"5","key":"2075_CR46","doi-asserted-by":"publisher","first-page":"e134172","DOI":"10.1172\/jci.insight.134172","volume":"5","author":"N-L Denning","year":"2020","unstructured":"Denning N-L, Aziz M, Murao A, Gurien SD, Ochani M, Prince JM, Wang P (2020) Extracellular CIRP as an endogenous TREM-1 ligand to fuel inflammation in sepsis. JCI insight 5(5):e134172. https:\/\/doi.org\/10.1172\/jci.insight.134172","journal-title":"JCI insight"},{"issue":"2","key":"2075_CR47","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.surg.2016.04.014","volume":"160","author":"C Cen","year":"2016","unstructured":"Cen C, Yang WL, Yen HT, Nicastro JM, Coppa GF, Wang P (2016) Deficiency of cold-inducible ribonucleic acid-binding protein reduces renal injury after ischemia-reperfusion. Surgery 160(2):473\u2013483. https:\/\/doi.org\/10.1016\/j.surg.2016.04.014","journal-title":"Surgery"},{"issue":"4","key":"2075_CR48","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.surg.2017.06.004","volume":"162","author":"C Cen","year":"2017","unstructured":"Cen C, McGinn J, Aziz M, Yang WL, Cagliani J, Nicastro JM, Coppa GF, Wang P (2017) Deficiency in cold-inducible RNA-binding protein attenuates acute respiratory distress syndrome induced by intestinal ischemia-reperfusion. Surgery 162(4):917\u2013927. https:\/\/doi.org\/10.1016\/j.surg.2017.06.004","journal-title":"Surgery"},{"key":"2075_CR49","doi-asserted-by":"publisher","first-page":"41363","DOI":"10.1038\/srep41363","volume":"7","author":"MM Khan","year":"2017","unstructured":"Khan MM, Yang W-L, Brenner M, Bolognese AC, Wang P (2017) Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Sci Rep 7:41363\u201341363. https:\/\/doi.org\/10.1038\/srep41363","journal-title":"Sci Rep"},{"issue":"2","key":"2075_CR50","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3892\/ijmm.2016.2451","volume":"37","author":"JP Idrovo","year":"2016","unstructured":"Idrovo JP, Jacob A, Yang WL, Wang Z, Yen HT, Nicastro J, Coppa GF, Wang P (2016) A deficiency in cold-inducible RNA-binding protein accelerates the inflammation phase and improves wound healing. Int J Mol Med 37(2):423\u2013428. https:\/\/doi.org\/10.3892\/ijmm.2016.2451","journal-title":"Int J Mol Med"},{"issue":"1","key":"2075_CR51","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1097\/SHK.0000000000000251","volume":"43","author":"A Godwin","year":"2015","unstructured":"Godwin A, Yang W-L, Sharma A, Khader A, Wang Z, Zhang F, Nicastro J, Coppa GF et al (2015) Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury. Shock 43(1):24\u201330. https:\/\/doi.org\/10.1097\/SHK.0000000000000251","journal-title":"Shock"},{"issue":"1","key":"2075_CR52","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.1038\/s41598-017-13139-z","volume":"8","author":"F Zhang","year":"2018","unstructured":"Zhang F, Brenner M, Yang WL, Wang P (2018) A cold-inducible RNA-binding protein (CIRP)-derived peptide attenuates inflammation and organ injury in septic mice. Sci Rep 8(1):3052. https:\/\/doi.org\/10.1038\/s41598-017-13139-z","journal-title":"Sci Rep"},{"issue":"10","key":"2075_CR53","doi-asserted-by":"publisher","first-page":"2053","DOI":"10.1016\/j.jpedsurg.2018.12.020","volume":"54","author":"N-L Denning","year":"2019","unstructured":"Denning N-L, Yang W-L, Hansen L, Prince J, Wang P (2019) C23, an oligopeptide derived from cold-inducible RNA-binding protein, suppresses inflammation and reduces lung injury in neonatal sepsis. J Pediatr Surg 54(10):2053\u20132060. https:\/\/doi.org\/10.1016\/j.jpedsurg.2018.12.020","journal-title":"J Pediatr Surg"},{"issue":"3","key":"2075_CR54","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/shk.0000000000000988","volume":"49","author":"J McGinn","year":"2018","unstructured":"McGinn J, Zhang F, Aziz M, Yang WL, Nicastro J, Coppa GF, Wang P (2018) The protective effect of a short peptide derived from cold-inducible RNA-binding protein in renal ischemia-reperfusion injury. Shock 49(3):269\u2013276. https:\/\/doi.org\/10.1097\/shk.0000000000000988","journal-title":"Shock"},{"issue":"4","key":"2075_CR55","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1097\/ta.0000000000001566","volume":"83","author":"F Zhang","year":"2017","unstructured":"Zhang F, Yang WL, Brenner M, Wang P (2017) Attenuation of hemorrhage-associated lung injury by adjuvant treatment with C23, an oligopeptide derived from cold-inducible RNA-binding protein. The journal of trauma and acute care surgery 83(4):690\u2013697. https:\/\/doi.org\/10.1097\/ta.0000000000001566","journal-title":"The journal of trauma and acute care surgery"},{"issue":"1","key":"2075_CR56","doi-asserted-by":"publisher","first-page":"e48075","DOI":"10.15252\/embr.201948075","volume":"21","author":"SD Gurien","year":"2020","unstructured":"Gurien SD, Aziz M, Jin H, Wang H, He M, Al-Abed Y, Nicastro JM, Coppa GF et al (2020) Extracellular microRNA 130b-3p inhibits eCIRP-induced inflammation. EMBO Rep 21(1):e48075. https:\/\/doi.org\/10.15252\/embr.201948075","journal-title":"EMBO Rep"},{"key":"2075_CR57","doi-asserted-by":"publisher","unstructured":"Zhou K, Cui S, Duan W, Zhang J, Huang J, Wang L, Gong Z, Zhou Y (2020) Cold-inducible RNA-binding protein contributes to intracerebral hemorrhage-induced brain injury via TLR4 signaling. Brain and behavior e01618. https:\/\/doi.org\/10.1002\/brb3.1618","DOI":"10.1002\/brb3.1618"},{"issue":"3","key":"2075_CR58","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.3892\/etm.2019.7767","volume":"18","author":"L Chen","year":"2019","unstructured":"Chen L, Tian Q, Wang W (2019) Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats. Experimental and therapeutic medicine 18(3):1515\u20131520. https:\/\/doi.org\/10.3892\/etm.2019.7767","journal-title":"Experimental and therapeutic medicine"},{"key":"2075_CR59","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/j.jtcvs.2018.08.100","volume":"157","author":"M Liu","year":"2018","unstructured":"Liu M, Li Y, Liu Y, Yan S, Liu G, Zhang Q, Ji B (2018) Cold-inducible RNA-binding protein as a novel target to alleviate blood-brain barrier damage induced by cardiopulmonary bypass. J Thorac Cardiovasc Surg 157:986\u2013996.e5. https:\/\/doi.org\/10.1016\/j.jtcvs.2018.08.100","journal-title":"J Thorac Cardiovasc Surg"},{"key":"2075_CR60","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neuint.2019.03.006","volume":"126","author":"YJ Sun","year":"2019","unstructured":"Sun YJ, Ma S, Fan B, Wang Y, Wang SR, Li GY (2019) Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway. Neurochem Int 126:86\u201395. https:\/\/doi.org\/10.1016\/j.neuint.2019.03.006","journal-title":"Neurochem Int"},{"issue":"5","key":"2075_CR61","doi-asserted-by":"publisher","first-page":"771","DOI":"10.4103\/1673-5374.182704","volume":"11","author":"G Wang","year":"2016","unstructured":"Wang G, Zhang JN, Guo JK, Cai Y, Sun HS, Dong K, Wu CG (2016) Neuroprotective effects of cold-inducible RNA-binding protein during mild hypothermia on traumatic brain injury. Neural Regen Res 11(5):771\u2013778. https:\/\/doi.org\/10.4103\/1673-5374.182704","journal-title":"Neural Regen Res"},{"key":"2075_CR62","doi-asserted-by":"publisher","first-page":"102","DOI":"10.3389\/fnins.2020.00102","volume":"14","author":"A Jacob","year":"2020","unstructured":"Jacob A, Wang P (2020) Alcohol intoxication and cognition:implications on mechanisms and therapeutic strategies. Front Neurosci 14:102. https:\/\/doi.org\/10.3389\/fnins.2020.00102","journal-title":"Front Neurosci"},{"issue":"1","key":"2075_CR63","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s10020-019-0092-3","volume":"25","author":"A Jacob","year":"2019","unstructured":"Jacob A, Ma Y, Nasiri E, Ochani M, Carrion J, Peng S, Brenner M, Huerta PT et al (2019) Extracellular cold inducible RNA-binding protein mediates binge alcohol-induced brain hypoactivity and impaired cognition in mice. Mol Med (Cambridge, Mass) 25(1):24. https:\/\/doi.org\/10.1186\/s10020-019-0092-3","journal-title":"Mol Med (Cambridge, Mass)"},{"key":"2075_CR64","doi-asserted-by":"publisher","unstructured":"Voet S, Srinivasan S, Lamkanfi M, van Loo G (2019) Inflammasomes in neuroinflammatory and neurodegenerative diseases. EMBO molecular medicine 11(6). https:\/\/doi.org\/10.15252\/emmm.201810248","DOI":"10.15252\/emmm.201810248"},{"issue":"7434","key":"2075_CR65","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D et al (2013) NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"key":"2075_CR66","doi-asserted-by":"publisher","first-page":"12504","DOI":"10.1038\/ncomms12504","volume":"7","author":"MJ Daniels","year":"2016","unstructured":"Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS et al (2016) Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models. Nat Commun 7:12504. https:\/\/doi.org\/10.1038\/ncomms12504","journal-title":"Nat Commun"},{"issue":"1","key":"2075_CR67","doi-asserted-by":"publisher","first-page":"3916","DOI":"10.1038\/s41467-018-06449-x","volume":"9","author":"J Flores","year":"2018","unstructured":"Flores J, No\u00ebl A, Foveau B, Lynham J, Lecrux C, LeBlanc AC (2018) Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer's disease mouse model. Nat Commun 9(1):3916. https:\/\/doi.org\/10.1038\/s41467-018-06449-x","journal-title":"Nat Commun"},{"issue":"1","key":"2075_CR68","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1189\/jlb.1212659","volume":"94","author":"D Lippai","year":"2013","unstructured":"Lippai D, Bala S, Petrasek J, Csak T, Levin I, Kurt-Jones EA, Szabo G (2013) Alcohol-induced IL-1\u03b2 in the brain is mediated by NLRP3\/ASC inflammasome activation that amplifies neuroinflammation. J Leukoc Biol 94(1):171\u2013182. https:\/\/doi.org\/10.1189\/jlb.1212659","journal-title":"J Leukoc Biol"},{"key":"2075_CR69","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3389\/fnins.2012.00077","volume":"6","author":"J Zou","year":"2012","unstructured":"Zou J, Crews FT (2012) Inflammasome-IL-1\u03b2 signaling mediates ethanol inhibition of hippocampal neurogenesis. Front Neurosci 6:77. https:\/\/doi.org\/10.3389\/fnins.2012.00077","journal-title":"Front Neurosci"},{"key":"2075_CR70","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.tox.2015.06.006","volume":"334","author":"X Wang","year":"2015","unstructured":"Wang X, Chu G, Yang Z, Sun Y, Zhou H, Li M, Shi J, Tian B et al (2015) Ethanol directly induced HMGB1 release through NOX2\/NLRP1 inflammasome in neuronal cells. Toxicology 334:104\u2013110. https:\/\/doi.org\/10.1016\/j.tox.2015.06.006","journal-title":"Toxicology"},{"key":"2075_CR71","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.redox.2017.04.020","volume":"12","author":"LR Hoyt","year":"2017","unstructured":"Hoyt LR, Randall MJ, Ather JL, DePuccio DP, Landry CC, Qian X, Janssen-Heininger YM, van der Vliet A et al (2017) Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome. Redox Biol 12:883\u2013896. https:\/\/doi.org\/10.1016\/j.redox.2017.04.020","journal-title":"Redox Biol"},{"key":"2075_CR72","doi-asserted-by":"publisher","first-page":"26571","DOI":"10.1038\/srep26571","volume":"6","author":"WL Yang","year":"2016","unstructured":"Yang WL, Sharma A, Wang Z, Li Z, Fan J, Wang P (2016) Cold-inducible RNA-binding protein causes endothelial dysfunction via activation of Nlrp3 inflammasome. Sci Rep 6:26571. https:\/\/doi.org\/10.1038\/srep26571","journal-title":"Sci Rep"},{"issue":"1","key":"2075_CR73","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.bj.2018.01.003","volume":"41","author":"C Laurent","year":"2018","unstructured":"Laurent C, Bu\u00e9e L, Blum D (2018) Tau and neuroinflammation: what impact for Alzheimer's disease and tauopathies? Biom J 41(1):21\u201333. https:\/\/doi.org\/10.1016\/j.bj.2018.01.003","journal-title":"Biom J"},{"issue":"3","key":"2075_CR74","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","volume":"53","author":"Y Yoshiyama","year":"2007","unstructured":"Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T et al (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53(3):337\u2013351. https:\/\/doi.org\/10.1016\/j.neuron.2007.01.010","journal-title":"Neuron"},{"key":"2075_CR75","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1742-2094-7-56","volume":"7","author":"DC Lee","year":"2010","unstructured":"Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN et al (2010) LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflammation 7:56. https:\/\/doi.org\/10.1186\/1742-2094-7-56","journal-title":"J Neuroinflammation"},{"issue":"6","key":"2075_CR76","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1016\/j.ajpath.2011.02.012","volume":"178","author":"M Sy","year":"2011","unstructured":"Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM (2011) Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol 178(6):2811\u20132822. https:\/\/doi.org\/10.1016\/j.ajpath.2011.02.012","journal-title":"Am J Pathol"},{"issue":"39","key":"2075_CR77","doi-asserted-by":"publisher","first-page":"8843","DOI":"10.1523\/jneurosci.2868-05.2005","volume":"25","author":"M Kitazawa","year":"2005","unstructured":"Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25(39):8843\u20138853. https:\/\/doi.org\/10.1523\/jneurosci.2868-05.2005","journal-title":"J Neurosci"},{"issue":"12","key":"2075_CR78","doi-asserted-by":"publisher","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","volume":"187","author":"M Kitazawa","year":"2011","unstructured":"Kitazawa M, Cheng D, Tsukamoto MR, Koike MA, Wes PD, Vasilevko V, Cribbs DH, LaFerla FM (2011) Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer's disease model. J Immunol 187(12):6539\u20136549. https:\/\/doi.org\/10.4049\/jimmunol.1100620","journal-title":"J Immunol"},{"issue":"11","key":"2075_CR79","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1038\/nn.4132","volume":"18","author":"H Asai","year":"2015","unstructured":"Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O et al (2015) Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci 18(11):1584\u20131593. https:\/\/doi.org\/10.1038\/nn.4132","journal-title":"Nat Neurosci"},{"issue":"3","key":"2075_CR80","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/j.tcb.2011.11.003","volume":"22","author":"ZH Cheung","year":"2012","unstructured":"Cheung ZH, Ip NY (2012) Cdk5: a multifaceted kinase in neurodegenerative diseases. Trends Cell Biol 22(3):169\u2013175. https:\/\/doi.org\/10.1016\/j.tcb.2011.11.003","journal-title":"Trends Cell Biol"},{"key":"2075_CR81","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.toxlet.2018.04.027","volume":"292","author":"N Xiao","year":"2018","unstructured":"Xiao N, Zhang F, Zhu B, Liu C, Lin Z, Wang H, Xie WB (2018) CDK5-mediated tau accumulation triggers methamphetamine-induced neuronal apoptosis via endoplasmic reticulum-associated degradation pathway. Toxicol Lett 292:97\u2013107. https:\/\/doi.org\/10.1016\/j.toxlet.2018.04.027","journal-title":"Toxicol Lett"},{"issue":"4","key":"2075_CR82","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/s0896-6273(03)00259-9","volume":"38","author":"W Noble","year":"2003","unstructured":"Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J et al (2003) Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38(4):555\u2013565. https:\/\/doi.org\/10.1016\/s0896-6273(03)00259-9","journal-title":"Neuron"},{"issue":"6784","key":"2075_CR83","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/35012636","volume":"405","author":"MS Lee","year":"2000","unstructured":"Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH (2000) Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature 405(6784):360\u2013364. https:\/\/doi.org\/10.1038\/35012636","journal-title":"Nature"},{"issue":"3","key":"2075_CR84","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1016\/s0896-6273(03)00627-5","volume":"40","author":"JC Cruz","year":"2003","unstructured":"Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH (2003) Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40(3):471\u2013483. https:\/\/doi.org\/10.1016\/s0896-6273(03)00627-5","journal-title":"Neuron"},{"issue":"2","key":"2075_CR85","doi-asserted-by":"publisher","first-page":"573","DOI":"10.3233\/jad-190099","volume":"70","author":"M Xu","year":"2019","unstructured":"Xu M, Huang Y, Song P, Huang Y, Huang W, Zhang HT, Hu Y (2019) AAV9-mediated Cdk5 inhibitory peptide reduces hyperphosphorylated tau and inflammation and ameliorates behavioral changes caused by overexpression of p25 in the brain. J Alzheim Diseas JAD 70(2):573\u2013585. https:\/\/doi.org\/10.3233\/jad-190099","journal-title":"J Alzheim Diseas JAD"},{"issue":"41","key":"2075_CR86","doi-asserted-by":"publisher","first-page":"9917","DOI":"10.1523\/jneurosci.0621-17.2017","volume":"37","author":"J Seo","year":"2017","unstructured":"Seo J, Kritskiy O, Watson LA, Barker SJ, Dey D, Raja WK, Lin YT, Ko T et al (2017) Inhibition of p25\/Cdk5 attenuates tauopathy in mouse and iPSC models of Frontotemporal dementia. J Neurosci 37(41):9917\u20139924. https:\/\/doi.org\/10.1523\/jneurosci.0621-17.2017","journal-title":"J Neurosci"},{"issue":"3","key":"2075_CR87","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.stemcr.2019.01.015","volume":"12","author":"L Reinhardt","year":"2019","unstructured":"Reinhardt L, Kordes S, Reinhardt P, Glatza M, Baumann M, Drexler HCA, Menninger S, Zischinsky G et al (2019) Dual inhibition of GSK3\u03b2 and CDK5 protects the cytoskeleton of neurons from neuroinflammatory-mediated degeneration in vitro and in vivo. Stem cell reports 12(3):502\u2013517. https:\/\/doi.org\/10.1016\/j.stemcr.2019.01.015","journal-title":"Stem cell reports"},{"issue":"2","key":"2075_CR88","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1007\/s12035-009-8075-y","volume":"40","author":"J Luo","year":"2009","unstructured":"Luo J (2009) GSK3beta in ethanol neurotoxicity. Mol Neurobiol 40(2):108\u2013121. https:\/\/doi.org\/10.1007\/s12035-009-8075-y","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2075_CR89","doi-asserted-by":"publisher","first-page":"3088","DOI":"10.1038\/s41598-018-21341-w","volume":"8","author":"Z Ji","year":"2018","unstructured":"Ji Z, Yuan L, Lu X, Ding H, Luo J, Ke ZJ (2018) Binge alcohol exposure causes neurobehavioral deficits and GSK3\u03b2 activation in the hippocampus of adolescent rats. Sci Rep 8(1):3088. https:\/\/doi.org\/10.1038\/s41598-018-21341-w","journal-title":"Sci Rep"},{"issue":"3","key":"2075_CR90","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/s41386-018-0181-y","volume":"44","author":"V Joshi","year":"2019","unstructured":"Joshi V, Subbanna S, Shivakumar M, Basavarajappa BS (2019) CB1R regulates CDK5 signaling and epigenetically controls Rac1 expression contributing to neurobehavioral abnormalities in mice postnatally exposed to ethanol. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 44(3):514\u2013525. https:\/\/doi.org\/10.1038\/s41386-018-0181-y","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"issue":"4","key":"2075_CR91","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s11064-009-0116-4","volume":"35","author":"M Saito","year":"2010","unstructured":"Saito M, Chakraborty G, Mao RF, Paik SM, Vadasz C, Saito M (2010) Tau phosphorylation and cleavage in ethanol-induced neurodegeneration in the developing mouse brain. Neurochem Res 35(4):651\u2013659. https:\/\/doi.org\/10.1007\/s11064-009-0116-4","journal-title":"Neurochem Res"},{"key":"2075_CR92","doi-asserted-by":"publisher","unstructured":"Zhou M, Aziz M, Denning NL, Yen HT, Ma G, Wang P (2020) Extracellular CIRP induces macrophage endotoxin tolerance through IL-6R-mediated STAT3 activation. JCI Insight 5(5). https:\/\/doi.org\/10.1172\/jci.insight.133715","DOI":"10.1172\/jci.insight.133715"},{"issue":"3","key":"2075_CR93","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.3233\/jad-160524","volume":"56","author":"PC Haddick","year":"2017","unstructured":"Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR et al (2017) A common variant of IL-6R is associated with elevated IL-6 pathway activity in Alzheimer's disease brains. J Alzheim Diseas JAD 56(3):1037\u20131054. https:\/\/doi.org\/10.3233\/jad-160524","journal-title":"J Alzheim Diseas JAD"},{"issue":"3\u20134","key":"2075_CR94","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/bf03033983","volume":"8","author":"DI Orellana","year":"2005","unstructured":"Orellana DI, Quintanilla RA, Gonzalez-Billault C, Maccioni RB (2005) Role of the JAKs\/STATs pathway in the intracellular calcium changes induced by interleukin-6 in hippocampal neurons. Neurotox Res 8(3\u20134):295\u2013304. https:\/\/doi.org\/10.1007\/bf03033983","journal-title":"Neurotox Res"},{"issue":"1","key":"2075_CR95","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.yexcr.2004.01.002","volume":"295","author":"RA Quintanilla","year":"2004","unstructured":"Quintanilla RA, Orellana DI, Gonz\u00e1lez-Billault C, Maccioni RB (2004) Interleukin-6 induces Alzheimer-type phosphorylation of tau protein by deregulating the cdk5\/p35 pathway. Exp Cell Res 295(1):245\u2013257. https:\/\/doi.org\/10.1016\/j.yexcr.2004.01.002","journal-title":"Exp Cell Res"},{"issue":"7784","key":"2075_CR96","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","volume":"575","author":"C Ising","year":"2019","unstructured":"Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S et al (2019) NLRP3 inflammasome activation drives tau pathology. Nature 575(7784):669\u2013673. https:\/\/doi.org\/10.1038\/s41586-019-1769-z","journal-title":"Nature"},{"key":"2075_CR97","doi-asserted-by":"publisher","first-page":"9895121","DOI":"10.1155\/2020\/9895121","volume":"2020","author":"BT Assefa","year":"2020","unstructured":"Assefa BT, Tafere GG, Wondafrash DZ, Gidey MT (2020) The bewildering effect of AMPK activators in Alzheimer's disease: review of the current evidence. Biomed Res Int 2020:9895121\u20139895118. https:\/\/doi.org\/10.1155\/2020\/9895121","journal-title":"Biomed Res Int"},{"issue":"3","key":"2075_CR98","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s00401-010-0759-x","volume":"121","author":"V Vingtdeux","year":"2011","unstructured":"Vingtdeux V, Davies P, Dickson DW, Marambaud P (2011) AMPK is abnormally activated in tangle- and pre-tangle-bearing neurons in Alzheimer's disease and other tauopathies. Acta Neuropathol 121(3):337\u2013349. https:\/\/doi.org\/10.1007\/s00401-010-0759-x","journal-title":"Acta Neuropathol"},{"issue":"3","key":"2075_CR99","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1042\/bj20101485","volume":"434","author":"C Thornton","year":"2011","unstructured":"Thornton C, Bright NJ, Sastre M, Muckett PJ, Carling D (2011) AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid \u03b2-peptide exposure. The Biochemical journal 434(3):503\u2013512. https:\/\/doi.org\/10.1042\/bj20101485","journal-title":"The Biochemical journal"},{"key":"2075_CR100","doi-asserted-by":"publisher","first-page":"26758","DOI":"10.1038\/srep26758","volume":"6","author":"M Domise","year":"2016","unstructured":"Domise M, Didier S, Marinangeli C, Zhao H, Chandakkar P, Bu\u00e9e L, Viollet B, Davies P et al (2016) AMP-activated protein kinase modulates tau phosphorylation and tau pathology in vivo. Sci Rep 6:26758. https:\/\/doi.org\/10.1038\/srep26758","journal-title":"Sci Rep"},{"key":"2075_CR101","doi-asserted-by":"publisher","first-page":"3511","DOI":"10.1172\/JCI133982","volume":"130","author":"HR Zimmermann","year":"2020","unstructured":"Zimmermann HR, Yang W, Kasica NP, Zhou X, Wang X, Beckelman BC, Lee J, Furdui CM et al (2020) Brain-specific repression of AMPK\u03b11 alleviates pathophysiology in Alzheimer\u2019s model mice. J Clin Invest 130:3511\u20133527. https:\/\/doi.org\/10.1172\/JCI133982","journal-title":"J Clin Invest"},{"issue":"3","key":"2075_CR102","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1111\/j.1471-4159.2007.04836.x","volume":"103","author":"M Saito","year":"2007","unstructured":"Saito M, Chakraborty G, Mao RF, Wang R, Cooper TB, Vadasz C, Saito M (2007) Ethanol alters lipid profiles and phosphorylation status of AMP-activated protein kinase in the neonatal mouse brain. J Neurochem 103(3):1208\u20131218. https:\/\/doi.org\/10.1111\/j.1471-4159.2007.04836.x","journal-title":"J Neurochem"},{"key":"2075_CR103","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.taap.2018.08.006","volume":"356","author":"Y Wang","year":"2018","unstructured":"Wang Y, Wang X, Li H, Xu M, Frank J, Luo J (2018) Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice. Toxicol Appl Pharmacol 356:172\u2013181. https:\/\/doi.org\/10.1016\/j.taap.2018.08.006","journal-title":"Toxicol Appl Pharmacol"},{"issue":"6","key":"2075_CR104","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1111\/febs.14332","volume":"285","author":"Y Gerakis","year":"2018","unstructured":"Gerakis Y, Hetz C (2018) Emerging roles of ER stress in the etiology and pathogenesis of Alzheimer's disease. FEBS J 285(6):995\u20131011. https:\/\/doi.org\/10.1111\/febs.14332","journal-title":"FEBS J"},{"key":"2075_CR105","doi-asserted-by":"publisher","first-page":"1543809","DOI":"10.1155\/2016\/1543809","volume":"2016","author":"JA Hern\u00e1ndez","year":"2016","unstructured":"Hern\u00e1ndez JA, L\u00f3pez-S\u00e1nchez RC, Rend\u00f3n-Ram\u00edrez A (2016) Lipids and oxidative stress associated with ethanol-induced neurological damage. Oxidative Med Cell Longev 2016:1543809\u20131543809. https:\/\/doi.org\/10.1155\/2016\/1543809","journal-title":"Oxidative Med Cell Longev"},{"issue":"2\u20133","key":"2075_CR106","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1016\/j.tox.2012.08.009","volume":"302","author":"Y Zhong","year":"2012","unstructured":"Zhong Y, Dong G, Luo H, Cao J, Wang C, Wu J, Feng YQ, Yue J (2012) Induction of brain CYP2E1 by chronic ethanol treatment and related oxidative stress in hippocampus, cerebellum, and brainstem. Toxicology 302(2\u20133):275\u2013284. https:\/\/doi.org\/10.1016\/j.tox.2012.08.009","journal-title":"Toxicology"},{"key":"2075_CR107","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neulet.2017.11.038","volume":"665","author":"J Li","year":"2018","unstructured":"Li J, Cheng J (2018) Apolipoprotein E4 exacerbates ethanol-induced neurotoxicity through augmentation of oxidative stress and apoptosis in N2a-APP cells. Neurosci Lett 665:1\u20136. https:\/\/doi.org\/10.1016\/j.neulet.2017.11.038","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"2075_CR108","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s11010-012-1526-1","volume":"375","author":"VD Reddy","year":"2013","unstructured":"Reddy VD, Padmavathi P, Kavitha G, Saradamma B, Varadacharyulu N (2013) Alcohol-induced oxidative\/nitrosative stress alters brain mitochondrial membrane properties. Mol Cell Biochem 375(1\u20132):39\u201347. https:\/\/doi.org\/10.1007\/s11010-012-1526-1","journal-title":"Mol Cell Biochem"},{"issue":"8","key":"2075_CR109","doi-asserted-by":"publisher","first-page":"e70833","DOI":"10.1371\/journal.pone.0070833","volume":"8","author":"J Haorah","year":"2013","unstructured":"Haorah J, Rump TJ, Xiong H (2013) Reduction of brain mitochondrial \u03b2-oxidation impairs complex I and V in chronic alcohol intake: the underlying mechanism for neurodegeneration. PLoS One 8(8):e70833. https:\/\/doi.org\/10.1371\/journal.pone.0070833","journal-title":"PLoS One"},{"issue":"1","key":"2075_CR110","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1186\/s40478-019-0839-7","volume":"7","author":"AU Joshi","year":"2019","unstructured":"Joshi AU, Van Wassenhove LD, Logas KR, Minhas PS, Andreasson KI, Weinberg KI, Chen C-H, Mochly-Rosen D (2019) Aldehyde dehydrogenase 2 activity and aldehydic load contribute to neuroinflammation and Alzheimer\u2019s disease related pathology. Acta Neuropathologica Communications 7(1):190. https:\/\/doi.org\/10.1186\/s40478-019-0839-7","journal-title":"Acta Neuropathologica Communications"},{"issue":"5","key":"2075_CR111","doi-asserted-by":"publisher","first-page":"e2775","DOI":"10.1038\/cddis.2017.187","volume":"8","author":"Z Li","year":"2017","unstructured":"Li Z, Fan EK, Liu J, Scott MJ, Li Y, Li S, Xie W, Billiar TR et al (2017) Cold-inducible RNA-binding protein through TLR4 signaling induces mitochondrial DNA fragmentation and regulates macrophage cell death after trauma. Cell Death Dis 8(5):e2775. https:\/\/doi.org\/10.1038\/cddis.2017.187","journal-title":"Cell Death Dis"},{"issue":"4","key":"2075_CR112","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1139\/bcb-2018-0248","volume":"97","author":"S Ciafr\u00e8","year":"2019","unstructured":"Ciafr\u00e8 S, Carito V, Ferraguti G, Greco A, Chaldakov GN, Fiore M, Ceccanti M (2019) How alcohol drinking affects our genes: an epigenetic point of view. Biochemistry and cell biology = Biochimie et biologie cellulaire 97(4):345\u2013356. https:\/\/doi.org\/10.1139\/bcb-2018-0248","journal-title":"Biochemistry and cell biology = Biochimie et biologie cellulaire"},{"issue":"12","key":"2075_CR113","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1177\/0269881119856001","volume":"33","author":"L Cantacorps","year":"2019","unstructured":"Cantacorps L, Alfonso-Loeches S, Guerri C, Valverde O (2019) Long-term epigenetic changes in offspring mice exposed to alcohol during gestation and lactation. Journal of psychopharmacology (Oxford, England) 33(12):1562\u20131572. https:\/\/doi.org\/10.1177\/0269881119856001","journal-title":"Journal of psychopharmacology (Oxford, England)"},{"issue":"11","key":"2075_CR114","doi-asserted-by":"publisher","first-page":"e0187634","DOI":"10.1371\/journal.pone.0187634","volume":"12","author":"N Garc\u00eda-Marchena","year":"2017","unstructured":"Garc\u00eda-Marchena N, Silva-Pe\u00f1a D, Mart\u00edn-Velasco AI, Villan\u00faa M, Araos P, Pedraz M, Maza-Quiroga R, Romero-Sanchiz P et al (2017) Decreased plasma concentrations of BDNF and IGF-1 in abstinent patients with alcohol use disorders. PLoS One 12(11):e0187634. https:\/\/doi.org\/10.1371\/journal.pone.0187634","journal-title":"PLoS One"},{"issue":"4","key":"2075_CR115","doi-asserted-by":"publisher","first-page":"308","DOI":"10.2174\/1570159x15666170825101308","volume":"17","author":"V Carito","year":"2019","unstructured":"Carito V, Ceccanti M, Ferraguti G, Coccurello R, Ciafr\u00e8 S, Tirassa P, Fiore M (2019) NGF and BDNF alterations by prenatal alcohol exposure. Curr Neuropharmacol 17(4):308\u2013317. https:\/\/doi.org\/10.2174\/1570159x15666170825101308","journal-title":"Curr Neuropharmacol"},{"key":"2075_CR116","doi-asserted-by":"publisher","first-page":"269","DOI":"10.3389\/fnagi.2019.00269","volume":"11","author":"G Canet","year":"2019","unstructured":"Canet G, Hernandez C, Zussy C, Chevallier N, Desrumaux C, Givalois L (2019) Is AD a stress-related disorder? Focus on the HPA Axis and its promising therapeutic targets. Front Aging Neurosci 11:269. https:\/\/doi.org\/10.3389\/fnagi.2019.00269","journal-title":"Front Aging Neurosci"},{"issue":"4","key":"2075_CR117","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1159\/000495521","volume":"77","author":"MH Ahmad","year":"2019","unstructured":"Ahmad MH, Fatima M, Mondal AC (2019) Role of hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis and insulin signaling in the pathophysiology of Alzheimer's disease. Neuropsychobiology 77(4):197\u2013205. https:\/\/doi.org\/10.1159\/000495521","journal-title":"Neuropsychobiology"},{"issue":"4","key":"2075_CR118","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/npp.2017.251","volume":"43","author":"TW Le Ma\u00eetre","year":"2018","unstructured":"Le Ma\u00eetre TW, Dhanabalan G, Bogdanovic N, Alkass K, Druid H (2018) Effects of alcohol abuse on proliferating cells, stem\/progenitor cells, and immature neurons in the adult human hippocampus. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 43(4):690\u2013699. https:\/\/doi.org\/10.1038\/npp.2017.251","journal-title":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology"},{"issue":"3","key":"2075_CR119","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.stem.2019.12.015","volume":"26","author":"J Zheng","year":"2020","unstructured":"Zheng J, Li HL, Tian N, Liu F, Wang L, Yin Y, Yue L, Ma L et al (2020) Interneuron accumulation of phosphorylated tau impairs adult hippocampal neurogenesis by suppressing GABAergic transmission. Cell Stem Cell 26(3):331\u2013345.e336. https:\/\/doi.org\/10.1016\/j.stem.2019.12.015","journal-title":"Cell Stem Cell"},{"key":"2075_CR120","doi-asserted-by":"publisher","unstructured":"Paudel YN, Angelopoulou E, Piperi C, Othman I, Aamir K, Shaikh MF (2020) Impact of HMGB1, RAGE, and TLR4 in Alzheimer's disease (AD): From risk factors to therapeutic targeting. Cells 9(2). https:\/\/doi.org\/10.3390\/cells9020383","DOI":"10.3390\/cells9020383"},{"issue":"1","key":"2075_CR121","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1186\/s12974-016-0670-z","volume":"13","author":"BW Festoff","year":"2016","unstructured":"Festoff BW, Sajja RK, van Dreden P, Cucullo L (2016) HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease. J Neuroinflammation 13(1):194. https:\/\/doi.org\/10.1186\/s12974-016-0670-z","journal-title":"J Neuroinflammation"},{"key":"2075_CR122","doi-asserted-by":"publisher","first-page":"31895","DOI":"10.1038\/srep31895","volume":"6","author":"K Fujita","year":"2016","unstructured":"Fujita K, Motoki K, Tagawa K, Chen X, Hama H, Nakajima K, Homma H, Tamura T et al (2016) HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. Sci Rep 6:31895. https:\/\/doi.org\/10.1038\/srep31895","journal-title":"Sci Rep"},{"issue":"3","key":"2075_CR123","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1097\/01.ALC.0000118316.20560.0D","volume":"28","author":"RM Gallucci","year":"2004","unstructured":"Gallucci RM, Sloan DK, O'Dell SJ, Reinke LA (2004) Differential expression of liver interleukin-6 receptor-\u03b1 in female versus male ethanol-consuming rats. Alcohol Clin Exp Res 28(3):365\u2013373. https:\/\/doi.org\/10.1097\/01.ALC.0000118316.20560.0D","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"2075_CR124","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3390\/biom6010006","volume":"6","author":"G \u0160imi\u0107","year":"2016","unstructured":"\u0160imi\u0107 G, Babi\u0107 Leko M, Wray S, Harrington C, Delalle I, Jovanov-Milo\u0161evi\u0107 N, Ba\u017eadona D, Bu\u00e9e L et al (2016) Tau protein hyperphosphorylation and aggregation in Alzheimer's disease and other tauopathies, and possible neuroprotective strategies. Biomolecules 6(1):6. https:\/\/doi.org\/10.3390\/biom6010006","journal-title":"Biomolecules"},{"issue":"5","key":"2075_CR125","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1038\/s41591-018-0004-z","volume":"24","author":"C Wang","year":"2018","unstructured":"Wang C, Najm R, Xu Q, Jeong DE, Walker D, Balestra ME, Yoon SY, Yuan H et al (2018) Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector. Nat Med 24(5):647\u2013657. https:\/\/doi.org\/10.1038\/s41591-018-0004-z","journal-title":"Nat Med"},{"issue":"1","key":"2075_CR126","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1038\/s41467-018-04529-6","volume":"9","author":"N Lipsman","year":"2018","unstructured":"Lipsman N, Meng Y, Bethune AJ, Huang Y, Lam B, Masellis M, Herrmann N, Heyn C et al (2018) Blood-brain barrier opening in Alzheimer's disease using MR-guided focused ultrasound. Nat Commun 9(1):2336\u20132336. https:\/\/doi.org\/10.1038\/s41467-018-04529-6","journal-title":"Nat Commun"},{"issue":"1","key":"2075_CR127","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1038\/s41467-019-08750-9","volume":"10","author":"V Cotero","year":"2019","unstructured":"Cotero V, Fan Y, Tsaava T, Kressel AM, Hancu I, Fitzgerald P, Wallace K, Kaanumalle S et al (2019) Noninvasive sub-organ ultrasound stimulation for targeted neuromodulation. Nat Commun 10(1):952\u2013952. https:\/\/doi.org\/10.1038\/s41467-019-08750-9","journal-title":"Nat Commun"},{"key":"2075_CR128","doi-asserted-by":"publisher","first-page":"86","DOI":"10.3389\/fphar.2019.00086","volume":"10","author":"K-T Chen","year":"2019","unstructured":"Chen K-T, Wei K-C, Liu H-L (2019) Theranostic strategy of focused ultrasound induced blood-brain barrier opening for CNS disease treatment. Front Pharmacol 10:86\u201386. https:\/\/doi.org\/10.3389\/fphar.2019.00086","journal-title":"Front Pharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02075-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-020-02075-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02075-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,20]],"date-time":"2021-08-20T23:08:10Z","timestamp":1629500890000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-020-02075-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"references-count":128,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["2075"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-02075-1","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,21]]},"assertion":[{"value":"28 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflict of interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}