{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T23:36:40Z","timestamp":1793403400729,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T00:00:00Z","timestamp":1599696000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771308"],"award-info":[{"award-number":["81771308"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["3177118"],"award-info":[{"award-number":["3177118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1007\/s12035-020-02086-y","type":"journal-article","created":{"date-parts":[[2020,9,10]],"date-time":"2020-09-10T19:26:20Z","timestamp":1599765980000},"page":"156-169","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["GABAergic Interneuron and Neurotransmission Are mTOR-Dependently Disturbed in Experimental Focal Cortical Dysplasia"],"prefix":"10.1007","volume":"58","author":[{"given":"Shaoping","family":"Zhong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanjing","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5135-4210","authenticated-orcid":false,"given":"Jing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,9,10]]},"reference":[{"issue":"1","key":"2086_CR1","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1528-1167.2010.02777.x","volume":"52","author":"I Blumcke","year":"2011","unstructured":"Blumcke I, Thom M, Aronica E, Armstrong DD, Vinters HV, Palmini A, Jacques TS, Avanzini G et al (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc task force of the ILAE Diagnostic Methods Commission. Epilepsia 52(1):158\u2013174. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02777.x","journal-title":"Epilepsia"},{"issue":"17","key":"2086_CR2","doi-asserted-by":"publisher","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","volume":"377","author":"I Blumcke","year":"2017","unstructured":"Blumcke I, Spreafico R, Haaker G, Coras R, Kobow K, Bien CG, Pfafflin M, Elger C et al (2017) Histopathological findings in brain tissue obtained during epilepsy surgery. N Engl J Med 377(17):1648\u20131656. https:\/\/doi.org\/10.1056\/NEJMoa1703784","journal-title":"N Engl J Med"},{"issue":"4","key":"2086_CR3","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nm.3824","volume":"21","author":"JS Lim","year":"2015","unstructured":"Lim JS, Kim WI, Kang HC, Kim SH, Park AH, Park EK, Cho YW, Kim S et al (2015) Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med 21(4):395\u2013400. https:\/\/doi.org\/10.1038\/nm.3824","journal-title":"Nat Med"},{"issue":"Pt 6","key":"2086_CR4","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1093\/brain\/awv045","volume":"138","author":"LA Jansen","year":"2015","unstructured":"Jansen LA, Mirzaa GM, Ishak GE, O'Roak BJ, Hiatt JB, Roden WH, Gunter SA, Christian SL et al (2015) PI3K\/AKT pathway mutations cause a spectrum of brain malformations from megalencephaly to focal cortical dysplasia. Brain J Neurol 138(Pt 6):1613\u20131628. https:\/\/doi.org\/10.1093\/brain\/awv045","journal-title":"Brain J Neurol"},{"issue":"6","key":"2086_CR5","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1007\/s00401-019-02061-5","volume":"138","author":"S Baldassari","year":"2019","unstructured":"Baldassari S, Ribierre T, Marsan E, Adle-Biassette H, Ferrand-Sorbets S, Bulteau C, Dorison N, Fohlen M et al (2019) Dissecting the genetic basis of focal cortical dysplasia: a large cohort study. Acta Neuropathol 138(6):885\u2013900. https:\/\/doi.org\/10.1007\/s00401-019-02061-5","journal-title":"Acta Neuropathol"},{"issue":"4","key":"2086_CR6","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1002\/ana.24368","volume":"77","author":"S Baulac","year":"2015","unstructured":"Baulac S, Ishida S, Marsan E, Miquel C, Biraben A, Nguyen DK, Nordli D, Cossette P et al (2015) Familial focal epilepsy with focal cortical dysplasia due to DEPDC5 mutations. Ann Neurol 77(4):675\u2013683. https:\/\/doi.org\/10.1002\/ana.24368","journal-title":"Ann Neurol"},{"issue":"4","key":"2086_CR7","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/ana.20949","volume":"60","author":"MC Ljungberg","year":"2006","unstructured":"Ljungberg MC, Bhattacharjee MB, Lu Y, Armstrong DL, Yoshor D, Swann JW, Sheldon M, D'Arcangelo G (2006) Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol 60(4):420\u2013429. https:\/\/doi.org\/10.1002\/ana.20949","journal-title":"Ann Neurol"},{"key":"2086_CR8","doi-asserted-by":"publisher","unstructured":"Crino PB (2015) mTOR signaling in epilepsy: insights from malformations of cortical development. Cold Spring Harb Perspect Med 5(4). https:\/\/doi.org\/10.1101\/cshperspect.a022442","DOI":"10.1101\/cshperspect.a022442"},{"issue":"4","key":"2086_CR9","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1002\/ana.22696","volume":"71","author":"DM Talos","year":"2012","unstructured":"Talos DM, Sun H, Kosaras B, Joseph A, Folkerth RD, Poduri A, Madsen JR, Black PM et al (2012) Altered inhibition in tuberous sclerosis and type IIb cortical dysplasia. Ann Neurol 71(4):539\u2013551. https:\/\/doi.org\/10.1002\/ana.22696","journal-title":"Ann Neurol"},{"issue":"7","key":"2086_CR10","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1212\/wnl.56.7.906","volume":"56","author":"PB Crino","year":"2001","unstructured":"Crino PB, Duhaime AC, Baltuch G, White R (2001) Differential expression of glutamate and GABA-A receptor subunit mRNA in cortical dysplasia. Neurology 56(7):906\u2013913. https:\/\/doi.org\/10.1212\/wnl.56.7.906","journal-title":"Neurology"},{"issue":"4","key":"2086_CR11","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1111\/j.0013-9580.2004.37703.x","volume":"45","author":"Z Ying","year":"2004","unstructured":"Ying Z, Bingaman W, Najm IM (2004) Increased numbers of coassembled PSD-95 to NMDA-receptor subunits NR2B and NR1 in human epileptic cortical dysplasia. Epilepsia 45(4):314\u2013321. https:\/\/doi.org\/10.1111\/j.0013-9580.2004.37703.x","journal-title":"Epilepsia"},{"issue":"1\u20132","key":"2086_CR12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/0022-510X(94)90198-8","volume":"123","author":"I Ferrer","year":"1994","unstructured":"Ferrer I, Oliver B, Russi A, Casas R, Rivera R (1994) Parvalbumin and calbindin-D28k immunocytochemistry in human neocortical epileptic foci. J Neurol Sci 123(1\u20132):18\u201325","journal-title":"J Neurol Sci"},{"issue":"42","key":"2086_CR13","doi-asserted-by":"publisher","first-page":"9649","DOI":"10.1523\/jneurosci.2687-05.2005","volume":"25","author":"ME Calcagnotto","year":"2005","unstructured":"Calcagnotto ME, Paredes MF, Tihan T, Barbaro NM, Baraban SC (2005) Dysfunction of synaptic inhibition in epilepsy associated with focal cortical dysplasia. J Neurosci 25(42):9649\u20139657. https:\/\/doi.org\/10.1523\/jneurosci.2687-05.2005","journal-title":"J Neurosci"},{"issue":"Suppl 3","key":"2086_CR14","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1111\/j.1528-1167.2010.02634.x","volume":"51","author":"VM Andre","year":"2010","unstructured":"Andre VM, Cepeda C, Vinters HV, Huynh M, Mathern GW, Levine MS (2010) Interneurons, GABAA currents, and subunit composition of the GABAA receptor in type I and type II cortical dysplasia. Epilepsia 51(Suppl 3):166\u2013170. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02634.x","journal-title":"Epilepsia"},{"issue":"1","key":"2086_CR15","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.eplepsyres.2009.09.021","volume":"88","author":"F Barinka","year":"2010","unstructured":"Barinka F, Druga R, Marusic P, Krsek P, Zamecnik J (2010) Calretinin immunoreactivity in focal cortical dysplasias and in non-malformed epileptic cortex. Epilepsy Res 88(1):76\u201386. https:\/\/doi.org\/10.1016\/j.eplepsyres.2009.09.021","journal-title":"Epilepsy Res"},{"issue":"7","key":"2086_CR16","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1111\/epi.13405","volume":"57","author":"V Medici","year":"2016","unstructured":"Medici V, Rossini L, Deleo F, Tringali G, Tassi L, Cardinale F, Bramerio M, de Curtis M et al (2016) Different parvalbumin and GABA expression in human epileptogenic focal cortical dysplasia. Epilepsia 57(7):1109\u20131119. https:\/\/doi.org\/10.1111\/epi.13405","journal-title":"Epilepsia"},{"issue":"4","key":"2086_CR17","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1111\/epi.13690","volume":"58","author":"JM Nakagawa","year":"2017","unstructured":"Nakagawa JM, Donkels C, Fauser S, Schulze-Bonhage A, Prinz M, Zentner J, Haas CA (2017) Characterization of focal cortical dysplasia with balloon cells by layer-specific markers: evidence for differential vulnerability of interneurons. Epilepsia 58(4):635\u2013645. https:\/\/doi.org\/10.1111\/epi.13690","journal-title":"Epilepsia"},{"issue":"2","key":"2086_CR18","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/ana.25403","volume":"85","author":"T Blauwblomme","year":"2019","unstructured":"Blauwblomme T, Dossi E, Pellegrino C, Goubert E, Iglesias BG, Sainte-Rose C, Rouach N, Nabbout R et al (2019) Gamma-aminobutyric acidergic transmission underlies interictal epileptogenicity in pediatric focal cortical dysplasia. Ann Neurol 85(2):204\u2013217. https:\/\/doi.org\/10.1002\/ana.25403","journal-title":"Ann Neurol"},{"issue":"7707","key":"2086_CR19","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1038\/s41586-018-0139-6","volume":"557","author":"FK Wong","year":"2018","unstructured":"Wong FK, Bercsenyi K, Sreenivasan V, Portales A, Fernandez-Otero M, Marin O (2018) Pyramidal cell regulation of interneuron survival sculpts cortical networks. Nature 557(7707):668\u2013673. https:\/\/doi.org\/10.1038\/s41586-018-0139-6","journal-title":"Nature"},{"issue":"11","key":"2086_CR20","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/epi.13200","volume":"56","author":"R Guerrini","year":"2015","unstructured":"Guerrini R, Duchowny M, Jayakar P, Krsek P, Kahane P, Tassi L, Melani F, Polster T et al (2015) Diagnostic methods and treatment options for focal cortical dysplasia. Epilepsia 56(11):1669\u20131686. https:\/\/doi.org\/10.1111\/epi.13200","journal-title":"Epilepsia"},{"key":"2086_CR21","doi-asserted-by":"publisher","first-page":"11753","DOI":"10.1038\/ncomms11753","volume":"7","author":"LS Hsieh","year":"2016","unstructured":"Hsieh LS, Wen JH, Claycomb K, Huang Y, Harrsch FA, Naegele JR, Hyder F, Buchanan GF et al (2016) Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nat Commun 7:11753. https:\/\/doi.org\/10.1038\/ncomms11753","journal-title":"Nat Commun"},{"issue":"1\u20132","key":"2086_CR22","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.jns.2013.05.029","volume":"332","author":"XF Meng","year":"2013","unstructured":"Meng XF, Yu JT, Song JH, Chi S, Tan L (2013) Role of the mTOR signaling pathway in epilepsy. J Neurol Sci 332(1\u20132):4\u201315. https:\/\/doi.org\/10.1016\/j.jns.2013.05.029","journal-title":"J Neurol Sci"},{"issue":"3","key":"2086_CR23","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1016\/j.neuron.2013.03.017","volume":"78","author":"HS Bateup","year":"2013","unstructured":"Bateup HS, Johnson CA, Denefrio CL, Saulnier JL, Kornacker K, Sabatini BL (2013) Excitatory\/inhibitory synaptic imbalance leads to hippocampal hyperexcitability in mouse models of tuberous sclerosis. Neuron 78(3):510\u2013522. https:\/\/doi.org\/10.1016\/j.neuron.2013.03.017","journal-title":"Neuron"},{"issue":"Pt 9","key":"2086_CR24","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1093\/brain\/awm175","volume":"130","author":"P Lamparello","year":"2007","unstructured":"Lamparello P, Baybis M, Pollard J, Hol EM, Eisenstat DD, Aronica E, Crino PB (2007) Developmental lineage of cell types in cortical dysplasia with balloon cells. Brain J Neurol 130(Pt 9):2267\u20132276. https:\/\/doi.org\/10.1093\/brain\/awm175","journal-title":"Brain J Neurol"},{"issue":"13","key":"2086_CR25","doi-asserted-by":"publisher","first-page":"3754","DOI":"10.1016\/j.celrep.2017.11.106","volume":"21","author":"AM D'Gama","year":"2017","unstructured":"D'Gama AM, Woodworth MB, Hossain AA, Bizzotto S, Hatem NE, LaCoursiere CM, Najm I, Ying Z et al (2017) Somatic mutations activating the mTOR pathway in dorsal telencephalic progenitors cause a continuum of cortical dysplasias. Cell Rep 21(13):3754\u20133766. https:\/\/doi.org\/10.1016\/j.celrep.2017.11.106","journal-title":"Cell Rep"},{"issue":"9","key":"2086_CR26","doi-asserted-by":"publisher","first-page":"3278","DOI":"10.1093\/cercor\/bhx199","volume":"28","author":"J Li","year":"2018","unstructured":"Li J, Wang C, Zhang Z, Wen Y, An L, Liang Q, Xu Z, Wei S et al (2018) Transcription factors Sp8 and Sp9 coordinately regulate olfactory bulb interneuron development. Cereb Cortex (New York, NY : 1991) 28(9):3278\u20133294. https:\/\/doi.org\/10.1093\/cercor\/bhx199","journal-title":"Cereb Cortex (New York, NY : 1991)"},{"issue":"12","key":"2086_CR27","doi-asserted-by":"publisher","first-page":"1445","DOI":"10.1038\/nm.3982","volume":"21","author":"ST Baek","year":"2015","unstructured":"Baek ST, Copeland B, Yun EJ, Kwon SK, Guemez-Gamboa A, Schaffer AE, Kim S, Kang HC et al (2015) An AKT3-FOXG1-reelin network underlies defective migration in human focal malformations of cortical development. Nat Med 21(12):1445\u20131454. https:\/\/doi.org\/10.1038\/nm.3982","journal-title":"Nat Med"},{"issue":"10","key":"2086_CR28","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/nrn1519","volume":"5","author":"H Markram","year":"2004","unstructured":"Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silberberg G, Wu C (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5(10):793\u2013807. https:\/\/doi.org\/10.1038\/nrn1519","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"2086_CR29","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.neuron.2018.10.009","volume":"100","author":"L Lim","year":"2018","unstructured":"Lim L, Mi D, Llorca A, Marin O (2018) Development and functional diversification of cortical interneurons. Neuron 100(2):294\u2013313. https:\/\/doi.org\/10.1016\/j.neuron.2018.10.009","journal-title":"Neuron"},{"issue":"5","key":"2086_CR30","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1016\/j.neuron.2013.08.014","volume":"79","author":"G Bartolini","year":"2013","unstructured":"Bartolini G, Ciceri G, Marin O (2013) Integration of GABAergic interneurons into cortical cell assemblies: lessons from embryos and adults. Neuron 79(5):849\u2013864. https:\/\/doi.org\/10.1016\/j.neuron.2013.08.014","journal-title":"Neuron"},{"issue":"45","key":"2086_CR31","doi-asserted-by":"publisher","first-page":"10792","DOI":"10.1523\/jneurosci.1824-17.2017","volume":"37","author":"A Maffei","year":"2017","unstructured":"Maffei A, Charrier C, Caiati MD, Barberis A, Mahadevan V, Woodin MA, Tyagarajan SK (2017) Emerging mechanisms underlying dynamics of GABAergic synapses. J Neurosci 37(45):10792\u201310799. https:\/\/doi.org\/10.1523\/jneurosci.1824-17.2017","journal-title":"J Neurosci"},{"issue":"Suppl 6","key":"2086_CR32","doi-asserted-by":"publisher","first-page":"S168","DOI":"10.1111\/j.1528-1157.2000.tb01576.x","volume":"41","author":"R Spreafico","year":"2000","unstructured":"Spreafico R, Tassi L, Colombo N, Bramerio M, Galli C, Garbelli R, Ferrario A, Lo Russo G et al (2000) Inhibitory circuits in human dysplastic tissue. Epilepsia 41(Suppl 6):S168\u2013S173. https:\/\/doi.org\/10.1111\/j.1528-1157.2000.tb01576.x","journal-title":"Epilepsia"},{"issue":"4","key":"2086_CR33","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1093\/jnen\/nlz009","volume":"78","author":"P Han","year":"2019","unstructured":"Han P, Welsh CT, Smith MT, Schmidt RE, Carroll SL (2019) Complex patterns of GABAergic neuronal deficiency and type 2 potassium-chloride Cotransporter immaturity in human focal cortical dysplasia. J Neuropathol Exp Neurol 78(4):365\u2013372. https:\/\/doi.org\/10.1093\/jnen\/nlz009","journal-title":"J Neuropathol Exp Neurol"},{"key":"2086_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2014.00001","volume":"7","author":"MC Weston","year":"2014","unstructured":"Weston MC, Chen H, Swann JW (2014) Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures. Front Mol Neurosci 7:1. https:\/\/doi.org\/10.3389\/fnmol.2014.00001","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"2086_CR35","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1136\/jnnp.34.4.369","volume":"34","author":"DC Taylor","year":"1971","unstructured":"Taylor DC, Falconer MA, Bruton CJ, Corsellis JA (1971) Focal dysplasia of the cerebral cortex in epilepsy. J Neurol Neurosurg Psychiatry 34(4):369\u2013387","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"4","key":"2086_CR36","doi-asserted-by":"publisher","first-page":"172","DOI":"10.5698\/1535-7597-13.4.172","volume":"13","author":"EM Powell","year":"2013","unstructured":"Powell EM (2013) Interneuron development and epilepsy: early genetic defects cause long-term consequences in seizures and susceptibility. Epilepsy Curr 13(4):172\u2013176. https:\/\/doi.org\/10.5698\/1535-7597-13.4.172","journal-title":"Epilepsy Curr"},{"issue":"5","key":"2086_CR37","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1016\/j.seizure.2010.04.003","volume":"19","author":"S Hanai","year":"2010","unstructured":"Hanai S, Saito T, Nakagawa E, Arai A, Otsuki T, Sasaki M, Goto Y, Itoh M (2010) Abnormal maturation of non-dysmorphic neurons in focal cortical dysplasia: immunohistochemical considerations. Seizure 19(5):274\u2013279. https:\/\/doi.org\/10.1016\/j.seizure.2010.04.003","journal-title":"Seizure"},{"issue":"6","key":"2086_CR38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1016\/j.brainresbull.2005.10.008","volume":"68","author":"J Zamecnik","year":"2006","unstructured":"Zamecnik J, Krsek P, Druga R, Marusic P, Benes V, Tichy M, Komarek V (2006) Densities of parvalbumin-immunoreactive neurons in non-malformed hippocampal sclerosis-temporal neocortex and in cortical dysplasias. Brain Res Bull 68(6):474\u2013481. https:\/\/doi.org\/10.1016\/j.brainresbull.2005.10.008","journal-title":"Brain Res Bull"},{"issue":"3","key":"2086_CR39","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1111\/j.1750-3639.1999.tb00534.x","volume":"9","author":"R Garbelli","year":"1999","unstructured":"Garbelli R, Munari C, De Biasi S, Vitellaro-Zuccarello L, Galli C, Bramerio M, Mai R, Battaglia G et al (1999) Taylor's cortical dysplasia: a confocal and ultrastructural immunohistochemical study. Brain Pathol (Zurich, Switzerland) 9(3):445\u2013461. https:\/\/doi.org\/10.1111\/j.1750-3639.1999.tb00534.x","journal-title":"Brain Pathol (Zurich, Switzerland)"},{"issue":"3","key":"2086_CR40","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/s0306-4522(01)00214-7","volume":"105","author":"AJ McDonald","year":"2001","unstructured":"McDonald AJ, Mascagni F (2001) Colocalization of calcium-binding proteins and GABA in neurons of the rat basolateral amygdala. Neuroscience 105(3):681\u2013693. https:\/\/doi.org\/10.1016\/s0306-4522(01)00214-7","journal-title":"Neuroscience"},{"issue":"8","key":"2086_CR41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0073750","volume":"8","author":"C Zhao","year":"2013","unstructured":"Zhao C, Eisinger B, Gammie SC (2013) Characterization of GABAergic neurons in the mouse lateral septum: a double fluorescence in situ hybridization and immunohistochemical study using tyramide signal amplification. PLoS One 8(8):e73750. https:\/\/doi.org\/10.1371\/journal.pone.0073750","journal-title":"PLoS One"},{"issue":"11","key":"2086_CR42","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1038\/nn.3536","volume":"16","author":"T Ma","year":"2013","unstructured":"Ma T, Wang C, Wang L, Zhou X, Tian M, Zhang Q, Zhang Y, Li J et al (2013) Subcortical origins of human and monkey neocortical interneurons. Nat Neurosci 16(11):1588\u20131597. https:\/\/doi.org\/10.1038\/nn.3536","journal-title":"Nat Neurosci"},{"issue":"Pt 6","key":"2086_CR43","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1113\/jphysiol.2009.181461","volume":"588","author":"IR Popescu","year":"2010","unstructured":"Popescu IR, Morton LA, Franco A, Di S, Ueta Y, Tasker JG (2010) Synchronized bursts of miniature inhibitory postsynaptic currents. J Physiol 588(Pt 6):939\u2013951. https:\/\/doi.org\/10.1113\/jphysiol.2009.181461","journal-title":"J Physiol"},{"issue":"14","key":"2086_CR44","doi-asserted-by":"publisher","first-page":"3151","DOI":"10.1002\/jnr.21752","volume":"86","author":"VM Andre","year":"2008","unstructured":"Andre VM, Cepeda C, Vinters HV, Huynh M, Mathern GW, Levine MS (2008) Pyramidal cell responses to gamma-aminobutyric acid differ in type I and type II cortical dysplasia. J Neurosci Res 86(14):3151\u20133162. https:\/\/doi.org\/10.1002\/jnr.21752","journal-title":"J Neurosci Res"},{"issue":"211","key":"2086_CR45","doi-asserted-by":"publisher","first-page":"pe54","DOI":"10.1126\/stke.2112003pe54","volume":"2003","author":"Y Otsu","year":"2003","unstructured":"Otsu Y, Murphy TH (2003) Miniature transmitter release: accident of nature or careful design? Sci STKE 2003(211):pe54. https:\/\/doi.org\/10.1126\/stke.2112003pe54","journal-title":"Sci STKE"},{"issue":"1","key":"2086_CR46","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s13041-019-0427-6","volume":"12","author":"JP Zhao","year":"2019","unstructured":"Zhao JP, Yoshii A (2019) Hyperexcitability of the local cortical circuit in mouse models of tuberous sclerosis complex. Mol Brain 12(1):6. https:\/\/doi.org\/10.1186\/s13041-019-0427-6","journal-title":"Mol Brain"},{"issue":"383","key":"2086_CR47","doi-asserted-by":"publisher","first-page":"ra65","DOI":"10.1126\/scisignal.aaa0354","volume":"8","author":"P Friedel","year":"2015","unstructured":"Friedel P, Kahle KT, Zhang J, Hertz N, Pisella LI, Buhler E, Schaller F, Duan J et al (2015) WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Sci Signal 8(383):ra65. https:\/\/doi.org\/10.1126\/scisignal.aaa0354","journal-title":"Sci Signal"},{"issue":"9","key":"2086_CR48","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.tins.2017.06.008","volume":"40","author":"YE Moore","year":"2017","unstructured":"Moore YE, Kelley MR, Brandon NJ, Deeb TZ, Moss SJ (2017) Seizing control of KCC2: A new therapeutic target for epilepsy. Trends Neurosci 40(9):555\u2013571. https:\/\/doi.org\/10.1016\/j.tins.2017.06.008","journal-title":"Trends Neurosci"},{"issue":"2","key":"2086_CR49","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.cell.2018.05.042","volume":"174","author":"M Delarue","year":"2018","unstructured":"Delarue M, Brittingham GP, Pfeffer S, Surovtsev IV, Pinglay S, Kennedy KJ, Schaffer M, Gutierrez JI et al (2018) mTORC1 controls phase separation and the biophysical properties of the cytoplasm by tuning crowding. Cell 174(2):338\u2013349.e320. https:\/\/doi.org\/10.1016\/j.cell.2018.05.042","journal-title":"Cell"},{"issue":"1","key":"2086_CR50","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1528-1167.2009.02341.x","volume":"51","author":"M Wong","year":"2010","unstructured":"Wong M (2010) Mammalian target of rapamycin (mTOR) inhibition as a potential antiepileptogenic therapy: from tuberous sclerosis to common acquired epilepsies. Epilepsia 51(1):27\u201336. https:\/\/doi.org\/10.1111\/j.1528-1167.2009.02341.x","journal-title":"Epilepsia"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02086-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-020-02086-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02086-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T02:37:14Z","timestamp":1631241434000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-020-02086-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["2086"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-02086-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,10]]},"assertion":[{"value":"3 May 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"The authors declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"This study was approved by the Ethics Committee of Zhongshan Hospital, Fudan University.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}}]}}