{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:04:05Z","timestamp":1791299045943,"version":"4.1.0"},"reference-count":157,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1007\/s12035-020-02236-2","type":"journal-article","created":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T13:03:41Z","timestamp":1610111021000},"page":"2379-2394","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Pathophysiological Clues to How the Emergent SARS-CoV-2 Can Potentially Increase the Susceptibility to Neurodegeneration"],"prefix":"10.1007","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4524-9462","authenticated-orcid":false,"given":"Mahsa","family":"Dolatshahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadmahdi","family":"Sabahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Hadi","family":"Aarabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"2236_CR1","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ijsu.2020.04.018","volume":"78","author":"M Nicola","year":"2020","unstructured":"Nicola M, Alsafi Z, Sohrabi C, Kerwan A, Al-Jabir A, Iosifidis C, Agha M, Agha R (2020) The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int J Surg 78:185\u2013193. https:\/\/doi.org\/10.1016\/j.ijsu.2020.04.018","journal-title":"Int J Surg"},{"issue":"6","key":"2236_CR2","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1001\/jamaneurol.2020.1127","volume":"77","author":"L Mao","year":"2020","unstructured":"Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, Chang J, Hong C et al (2020) Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol 77(6):683\u2013690. https:\/\/doi.org\/10.1001\/jamaneurol.2020.1127","journal-title":"JAMA Neurol"},{"issue":"23","key":"2236_CR3","doi-asserted-by":"publisher","first-page":"2268","DOI":"10.1056\/NEJMc2008597","volume":"382","author":"J Helms","year":"2020","unstructured":"Helms J, Kremer S, Merdji H, Clere-Jehl R, Schenck M, Kummerlen C, Collange O, Boulay C et al (2020) Neurologic features in severe SARS-CoV-2 infection. N Engl J Med 382(23):2268\u20132270. https:\/\/doi.org\/10.1056\/NEJMc2008597","journal-title":"N Engl J Med"},{"key":"2236_CR4","doi-asserted-by":"publisher","first-page":"105921","DOI":"10.1016\/j.clineuro.2020.105921","volume":"194","author":"V Montalvan","year":"2020","unstructured":"Montalvan V, Lee J, Bueso T, De Toledo J, Rivas K (2020) Neurological manifestations of COVID-19 and other coronavirus infections: a systematic review. Clin Neurol Neurosurg 194:105921. https:\/\/doi.org\/10.1016\/j.clineuro.2020.105921","journal-title":"Clin Neurol Neurosurg"},{"key":"2236_CR5","doi-asserted-by":"publisher","unstructured":"Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S et al Neurological associations of COVID-19. Lancet Neurol. https:\/\/doi.org\/10.1016\/S1474-4422(20)30221-0","DOI":"10.1016\/S1474-4422(20)30221-0"},{"key":"2236_CR6","doi-asserted-by":"publisher","unstructured":"Coolen T, Lolli V, Sadeghi N, Rova\u00ef A, Trotta N, Taccone FS, Creteur J, Henrard S et al (2020) Early postmortem brain MRI findings in COVID-19 non-survivors. Neurology. https:\/\/doi.org\/10.1212\/wnl.0000000000010116","DOI":"10.1212\/wnl.0000000000010116"},{"key":"2236_CR7","doi-asserted-by":"publisher","first-page":"202422","DOI":"10.1148\/radiol.2020202422","volume":"2020","author":"L Chougar","year":"2020","unstructured":"Chougar L, Shor N, Weiss N, Galanaud D, Leclercq D, Mathon B, Belkacem S, Stro\u00ebr S et al (2020) Retrospective observational study of brain magnetic resonance imaging findings in patients with acute SARS-CoV-2 infection and neurological manifestations. Radiology 2020:202422. https:\/\/doi.org\/10.1148\/radiol.2020202422","journal-title":"Radiology"},{"issue":"10","key":"2236_CR8","doi-asserted-by":"publisher","first-page":"1379","DOI":"10.1021\/acschemneuro.0c00217","volume":"11","author":"S Gandhi","year":"2020","unstructured":"Gandhi S, Srivastava AK, Ray U, Tripathi PP (2020) Is the collapse of the respiratory center in the brain responsible for respiratory breakdown in COVID-19 patients? ACS Chem Neurosci 11(10):1379\u20131381. https:\/\/doi.org\/10.1021\/acschemneuro.0c00217","journal-title":"ACS Chem Neurosci"},{"key":"2236_CR9","doi-asserted-by":"publisher","first-page":"106217","DOI":"10.1016\/j.clineuro.2020.106217","volume":"198","author":"M Nouri-Vaskeh","year":"2020","unstructured":"Nouri-Vaskeh M, Sharifi A, Khalili N, Zand R, Sharifi A (2020) Dyspneic and non-dyspneic (silent) hypoxemia in COVID-19: possible neurological mechanism. Clin Neurol Neurosurg 198:106217. https:\/\/doi.org\/10.1016\/j.clineuro.2020.106217","journal-title":"Clin Neurol Neurosurg"},{"issue":"26","key":"2236_CR10","doi-asserted-by":"publisher","first-page":"2574","DOI":"10.1056\/NEJMc2009191","volume":"382","author":"G Toscano","year":"2020","unstructured":"Toscano G, Palmerini F, Ravaglia S, Ruiz L, Invernizzi P, Cuzzoni MG, Franciotta D, Baldanti F et al (2020) Guillain\u2013Barr\u00e9 syndrome associated with SARS-CoV-2. N Engl J Med 382(26):2574\u20132576. https:\/\/doi.org\/10.1056\/NEJMc2009191","journal-title":"N Engl J Med"},{"issue":"4","key":"2236_CR11","doi-asserted-by":"publisher","first-page":"3338","DOI":"10.1128\/jvi.73.4.3338-3350.1999","volume":"73","author":"N Arbour","year":"1999","unstructured":"Arbour N, C\u00f4t\u00e9 G, Lachance C, Tardieu M, Cashman NR, Talbot PJ (1999) Acute and persistent infection of human neural cell lines by human coronavirus OC43. J Virol 73(4):3338\u20133350. https:\/\/doi.org\/10.1128\/jvi.73.4.3338-3350.1999","journal-title":"J Virol"},{"key":"2236_CR12","doi-asserted-by":"publisher","unstructured":"Yang AC, Kern F, Losada PM, Maat CA, Schmartz G, Fehlmann T, Schaum N, Lee DP, Calcuttawala K, Vest RT, Gate D, Berdnik D, McNerney MW, Channappa D, Cobos I, Ludwig N, Schulz-Schaeffer WJ, Keller A, Wyss-Coray T (2020) Broad transcriptional dysregulation of brain and choroid plexus cell types with COVID-19. bioRxiv:2020.2010.2022.349415. doi:https:\/\/doi.org\/10.1101\/2020.10.22.349415","DOI":"10.1101\/2020.10.22.349415"},{"issue":"11","key":"2236_CR13","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/S1474-4422(18)30295-3","volume":"17","author":"ER Dorsey","year":"2018","unstructured":"Dorsey ER, Elbaz A, Nichols E, Abd-Allah F, Abdelalim A, Adsuar JC, Ansha MG, Brayne C et al (2018) Global, regional, and national burden of Parkinson\u2019s disease, 1990&#x2013;2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17(11):939\u2013953. https:\/\/doi.org\/10.1016\/S1474-4422(18)30295-3","journal-title":"Lancet Neurol"},{"issue":"1","key":"2236_CR14","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/S1474-4422(18)30403-4","volume":"18","author":"E Nichols","year":"2019","unstructured":"Nichols E, Szoeke CEI, Vollset SE, Abbasi N, Abd-Allah F, Abdela J, Aichour MTE, Akinyemi RO et al (2019) Global, regional, and national burden of Alzheimer\u2019s disease and other dementias, 1990&#x2013;2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 18(1):88\u2013106. https:\/\/doi.org\/10.1016\/S1474-4422(18)30403-4","journal-title":"Lancet Neurol"},{"key":"2236_CR15","doi-asserted-by":"publisher","first-page":"728","DOI":"10.3389\/fnins.2019.00728","volume":"13","author":"X Castillo","year":"2019","unstructured":"Castillo X, Castro-Obreg\u00f3n S, Guti\u00e9rrez-Becker B, Guti\u00e9rrez-Ospina G, Karalis N, Khalil AA, Lopez-Noguerola JS, Rodr\u00edguez LL et al (2019) Re-thinking the etiological framework of neurodegeneration. Front Neurosci 13:728. https:\/\/doi.org\/10.3389\/fnins.2019.00728","journal-title":"Front Neurosci"},{"issue":"5","key":"2236_CR16","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1242\/dmm.030205","volume":"10","author":"AD Gitler","year":"2017","unstructured":"Gitler AD, Dhillon P, Shorter J (2017) Neurodegenerative disease: models, mechanisms, and a new hope. Disease Models &amp. Mechanisms 10(5):499\u2013502. https:\/\/doi.org\/10.1242\/dmm.030205","journal-title":"Mechanisms"},{"issue":"3","key":"2236_CR17","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3988\/jcn.2017.13.3.227","volume":"13","author":"JE Kim","year":"2017","unstructured":"Kim JE, Heo JH, Kim HO, Song SH, Park SS, Park TH, Ahn JY, Kim MK et al (2017) Neurological complications during treatment of Middle East respiratory syndrome. J Clin Neurol 13(3):227\u2013233. https:\/\/doi.org\/10.3988\/jcn.2017.13.3.227","journal-title":"J Clin Neurol"},{"issue":"2","key":"2236_CR18","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1176\/jnp.7.2.125","volume":"7","author":"SR Cheyette","year":"1995","unstructured":"Cheyette SR, Cummings JL (1995) Encephalitis lethargica: lessons for contemporary neuropsychiatry. J Neuropsychiatr Clin Neurosci 7(2):125\u2013134. https:\/\/doi.org\/10.1176\/jnp.7.2.125","journal-title":"J Neuropsychiatr Clin Neurosci"},{"issue":"7","key":"2236_CR19","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/s1474-4422(20)30189-7","volume":"19","author":"A Giordano","year":"2020","unstructured":"Giordano A, Schwarz G, Cacciaguerra L, Esposito F, Filippi M (2020) COVID-19: can we learn from encephalitis lethargica? Lancet Neurol 19(7):570. https:\/\/doi.org\/10.1016\/s1474-4422(20)30189-7","journal-title":"Lancet Neurol"},{"issue":"12","key":"2236_CR20","doi-asserted-by":"publisher","first-page":"3060","DOI":"10.1523\/jneurosci.1740-17.2018","volume":"38","author":"S Hosseini","year":"2018","unstructured":"Hosseini S, Wilk E, Michaelsen-Preusse K, Gerhauser I, Baumg\u00e4rtner W, Geffers R, Schughart K, Korte M (2018) Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function. J Neurosci 38(12):3060\u20133080. https:\/\/doi.org\/10.1523\/jneurosci.1740-17.2018","journal-title":"J Neurosci"},{"issue":"6","key":"2236_CR21","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1016\/j.ajpath.2011.02.012","volume":"178","author":"M Sy","year":"2011","unstructured":"Sy M, Kitazawa M, Medeiros R, Whitman L, Cheng D, Lane TE, Laferla FM (2011) Inflammation induced by infection potentiates tau pathological features in transgenic mice. Am J Pathol 178(6):2811\u20132822. https:\/\/doi.org\/10.1016\/j.ajpath.2011.02.012","journal-title":"Am J Pathol"},{"issue":"4","key":"2236_CR22","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.nrleng.2020.04.002","volume":"35","author":"PJ Serrano-Castro","year":"2020","unstructured":"Serrano-Castro PJ, Estivill-Torr\u00fas G, Cabezudo-Garc\u00eda P, Reyes-Bueno JA, Ciano Petersen N, Aguilar-Castillo MJ, Su\u00e1rez-P\u00e9rez J, Jim\u00e9nez-Hern\u00e1ndez MD et al (2020) Impact of SARS-CoV-2 infection on neurodegenerative and neuropsychiatric diseases: a delayed pandemic? Neurolog\u00eda (English Edition) 35(4):245\u2013251. https:\/\/doi.org\/10.1016\/j.nrleng.2020.04.002","journal-title":"Neurolog\u00eda (English Edition)"},{"issue":"10","key":"2236_CR23","doi-asserted-by":"publisher","first-page":"1380","DOI":"10.1038\/s41593-018-0227-9","volume":"21","author":"A Louveau","year":"2018","unstructured":"Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J et al (2018) CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci 21(10):1380\u20131391. https:\/\/doi.org\/10.1038\/s41593-018-0227-9","journal-title":"Nat Neurosci"},{"issue":"2","key":"2236_CR24","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1590\/1980-57642018dn12-020004","volume":"12","author":"MME Silva","year":"2018","unstructured":"Silva MME, Mercer PBS, Witt MCZ, Pessoa RR (2018) Olfactory dysfunction in Alzheimer\u2019s disease systematic review and meta-analysis. Dement Neuropsychol 12(2):123\u2013132. https:\/\/doi.org\/10.1590\/1980-57642018dn12-020004","journal-title":"Dement Neuropsychol"},{"key":"2236_CR25","doi-asserted-by":"publisher","unstructured":"Lee J, Nallani R, Cass L, Bhalla V, Chiu A, Villwock J (2020) A systematic review of the neuropathologic findings of post-viral olfactory dysfunction: implications and novel insight for the COVID-19 pandemic. Am J Rhinol Allergy 1945892420957853. doi:https:\/\/doi.org\/10.1177\/1945892420957853","DOI":"10.1177\/1945892420957853"},{"key":"2236_CR26","doi-asserted-by":"publisher","unstructured":"Guo A-X, Cui J-J, OuYang Q-Y, He L, Guo C-X, Yin J-Y (2020) The clinical characteristics and mortal causes analysis of COVID-19 death patients. medRxiv:2020.2004.2012.20062380. doi:https:\/\/doi.org\/10.1101\/2020.04.12.20062380","DOI":"10.1101\/2020.04.12.20062380"},{"key":"2236_CR27","doi-asserted-by":"publisher","unstructured":"Qi J, Zhou Y, Hua J, Zhang L, Bian J, Liu B, Zhao Z, Jin S (2020) The scRNA-seq expression profiling of the receptor ACE2 and the cellular protease TMPRSS2 reveals human organs susceptible to COVID-19 infection. bioRxiv. https:\/\/doi.org\/10.1101\/2020.04.16.045690","DOI":"10.1101\/2020.04.16.045690"},{"key":"2236_CR28","doi-asserted-by":"publisher","unstructured":"Brann D, Tsukahara T, Weinreb C, Lipovsek M, Van den Berge K, Gong B, Chance R, Macaulay I et al (2020) Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. bioRxiv. https:\/\/doi.org\/10.1101\/2020.03.25.009084","DOI":"10.1101\/2020.03.25.009084"},{"key":"2236_CR29","unstructured":"Bagasra O, Pandey P, McCean E, Albrecht H Infectivity of human olfactory neurons to SARS-CoV-2: a link to anosmia."},{"issue":"10","key":"2236_CR30","doi-asserted-by":"publisher","first-page":"2722","DOI":"10.1093\/brain\/awx208","volume":"140","author":"B Zapiec","year":"2017","unstructured":"Zapiec B, Dieriks BV, Tan S, Faull RLM, Mombaerts P, Curtis MA (2017) A ventral glomerular deficit in Parkinson\u2019s disease revealed by whole olfactory bulb reconstruction. Brain 140(10):2722\u20132736. https:\/\/doi.org\/10.1093\/brain\/awx208","journal-title":"Brain"},{"issue":"2","key":"2236_CR31","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1007\/s10072-018-3629-2","volume":"40","author":"H Sanjari Moghaddam","year":"2019","unstructured":"Sanjari Moghaddam H, Dolatshahi M, Salardini E, Aarabi MH (2019) Association of olfaction dysfunction with brain microstructure in prodromal Parkinson disease. Neurol Sci 40(2):283\u2013291. https:\/\/doi.org\/10.1007\/s10072-018-3629-2","journal-title":"Neurol Sci"},{"issue":"10229","key":"2236_CR32","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/s0140-6736(20)30628-0","volume":"395","author":"P Mehta","year":"2020","unstructured":"Mehta P, McAuley DF, Brown M, Sanchez E, Tattersall RS, Manson JJ (2020) COVID-19: consider cytokine storm syndromes and immunosuppression. Lancet 395(10229):1033\u20131034. https:\/\/doi.org\/10.1016\/s0140-6736(20)30628-0","journal-title":"Lancet"},{"issue":"12","key":"2236_CR33","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.1007\/s12035-020-02094-y","volume":"57","author":"S Mohammadi","year":"2020","unstructured":"Mohammadi S, Moosaie F, Aarabi MH (2020) Understanding the immunologic characteristics of neurologic manifestations of SARS-CoV-2 and potential immunological mechanisms. Mol Neurobiol 57(12):5263\u20135275. https:\/\/doi.org\/10.1007\/s12035-020-02094-y","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2236_CR34","doi-asserted-by":"publisher","first-page":"12050","DOI":"10.1038\/s41598-018-30487-6","volume":"8","author":"A Ng","year":"2018","unstructured":"Ng A, Tam WW, Zhang MW, Ho CS, Husain SF, McIntyre RS, Ho RC (2018) IL-1\u03b2, IL-6, TNF-\u03b1 and CRP in elderly patients with depression or Alzheimer\u2019s disease: systematic review and meta-analysis. Sci Rep 8(1):12050. https:\/\/doi.org\/10.1038\/s41598-018-30487-6","journal-title":"Sci Rep"},{"key":"2236_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.3233\/JAD-200537","volume":"76","author":"SX Naughton","year":"2020","unstructured":"Naughton SX, Raval U, Pasinetti GM (2020) Potential novel role of COVID-19 in Alzheimer\u2019s disease and preventative mitigation strategies. J Alzheimers Dis 76:21\u201325. https:\/\/doi.org\/10.3233\/JAD-200537","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"2236_CR36","doi-asserted-by":"publisher","first-page":"8865","DOI":"10.1096\/fj.201802418R","volume":"33","author":"K-L Siu","year":"2019","unstructured":"Siu K-L, Yuen K-S, Castano-Rodriguez C, Ye Z-W, Yeung M-L, Fung S-Y, Yuan S, Chan C-P et al (2019) Severe acute respiratory syndrome coronavirus ORF3a protein activates the NLRP3 inflammasome by promoting TRAF3-dependent ubiquitination of ASC. FASEB J 33(8):8865\u20138877. https:\/\/doi.org\/10.1096\/fj.201802418R","journal-title":"FASEB J"},{"key":"2236_CR37","doi-asserted-by":"publisher","unstructured":"Tuma R, Guedes B, Carra R, Iepsen B, Rodrigues J, Camelo Filho AE, Kubota G, Ferrari M, Studart-Neto A, Oku M, Terrim S, Lopes C, Passos Neto CE, Dalben M, De Souza J, Baima JP, Da Silva T, Perissinotti I, Martin MDG, Goncalves M, Fortini I, Smid J, Adoni T, Lucatto L, Nitrini R, Gomes H, Castro LH (2020) Clinical, cerebrospinal fluid and neuroimaging findings in COVID-19 encephalopathy: a case series. medRxiv:2020.2008.2028.20181883. doi:https:\/\/doi.org\/10.1101\/2020.08.28.20181883","DOI":"10.1101\/2020.08.28.20181883"},{"issue":"11","key":"2236_CR38","doi-asserted-by":"publisher","first-page":"3021","DOI":"10.1007\/s10072-020-04694-x","volume":"41","author":"FAA de Oliveira","year":"2020","unstructured":"de Oliveira FAA, Palmeira DCC, Rocha-Filho PAS (2020) Headache and pleocytosis in CSF associated with COVID-19: case report. Neurol Sci 41(11):3021\u20133022. https:\/\/doi.org\/10.1007\/s10072-020-04694-x","journal-title":"Neurol Sci"},{"issue":"6","key":"2236_CR39","doi-asserted-by":"publisher","first-page":"e245","DOI":"10.1016\/s2666-5247(20)30115-4","volume":"1","author":"B Hanley","year":"2020","unstructured":"Hanley B, Naresh KN, Roufosse C, Nicholson AG, Weir J, Cooke GS, Thursz M, Manousou P et al (2020) Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study. Lancet Microbe 1(6):e245\u2013e253. https:\/\/doi.org\/10.1016\/s2666-5247(20)30115-4","journal-title":"Lancet Microbe"},{"issue":"5","key":"2236_CR40","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1007\/s00401-014-1345-4","volume":"128","author":"V Grozdanov","year":"2014","unstructured":"Grozdanov V, Bliederhaeuser C, Ruf WP, Roth V, Fundel-Clemens K, Zondler L, Brenner D, Martin-Villalba A et al (2014) Inflammatory dysregulation of blood monocytes in Parkinson\u2019s disease patients. Acta Neuropathol 128(5):651\u2013663. https:\/\/doi.org\/10.1007\/s00401-014-1345-4","journal-title":"Acta Neuropathol"},{"key":"2236_CR41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1007\/978-3-211-45295-0_57","volume":"70","author":"M Sawada","year":"2006","unstructured":"Sawada M, Imamura K, Nagatsu T (2006) Role of cytokines in inflammatory process in Parkinson\u2019s disease. J Neural Transm Suppl 70:373\u2013381. https:\/\/doi.org\/10.1007\/978-3-211-45295-0_57","journal-title":"J Neural Transm Suppl"},{"issue":"7784","key":"2236_CR42","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1038\/s41586-019-1769-z","volume":"575","author":"C Ising","year":"2019","unstructured":"Ising C, Venegas C, Zhang S, Scheiblich H, Schmidt SV, Vieira-Saecker A, Schwartz S, Albasset S et al (2019) NLRP3 inflammasome activation drives tau pathology. Nature 575(7784):669\u2013673. https:\/\/doi.org\/10.1038\/s41586-019-1769-z","journal-title":"Nature"},{"issue":"7434","key":"2236_CR43","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/nature11729","volume":"493","author":"MT Heneka","year":"2013","unstructured":"Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D et al (2013) NLRP3 is activated in Alzheimer\u2019s disease and contributes to pathology in APP\/PS1 mice. Nature 493(7434):674\u2013678. https:\/\/doi.org\/10.1038\/nature11729","journal-title":"Nature"},{"issue":"1-2","key":"2236_CR44","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0165-5728(01)00496-9","volume":"124","author":"T Togo","year":"2002","unstructured":"Togo T, Akiyama H, Iseki E, Kondo H, Ikeda K, Kato M, Oda T, Tsuchiya K et al (2002) Occurrence of T cells in the brain of Alzheimer\u2019s disease and other neurological diseases. J Neuroimmunol 124(1-2):83\u201392. https:\/\/doi.org\/10.1016\/s0165-5728(01)00496-9","journal-title":"J Neuroimmunol"},{"issue":"9","key":"2236_CR45","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S1474-4422(20)30221-0","volume":"19","author":"MA Ellul","year":"2020","unstructured":"Ellul MA, Benjamin L, Singh B, Lant S, Michael BD, Easton A, Kneen R, Defres S et al (2020) Neurological associations of COVID-19. Lancet Neurol 19(9):767\u2013783. https:\/\/doi.org\/10.1016\/S1474-4422(20)30221-0","journal-title":"Lancet Neurol"},{"issue":"1","key":"2236_CR46","doi-asserted-by":"publisher","first-page":"14102","DOI":"10.1038\/s41598-019-50681-4","volume":"9","author":"J-H Park","year":"2019","unstructured":"Park J-H, Hong J-H, Lee S-W, Ji HD, Jung J-A, Yoon K-W, Lee J-I, Won KS et al (2019) The effect of chronic cerebral hypoperfusion on the pathology of Alzheimer\u2019s disease: a positron emission tomography study in rats. Sci Rep 9(1):14102. https:\/\/doi.org\/10.1038\/s41598-019-50681-4","journal-title":"Sci Rep"},{"issue":"12","key":"2236_CR47","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1038\/nrn3114","volume":"12","author":"BV Zlokovic","year":"2011","unstructured":"Zlokovic BV (2011) Neurovascular pathways to neurodegeneration in Alzheimer\u2019s disease and other disorders. Nat Rev Neurosci 12(12):723\u2013738. https:\/\/doi.org\/10.1038\/nrn3114","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2236_CR48","doi-asserted-by":"publisher","first-page":"e00453","DOI":"10.1128\/mSystems.00453-20","volume":"5","author":"D van der Lelie","year":"2020","unstructured":"van der Lelie D, Taghavi S (2020) COVID-19 and the gut microbiome: more than a gut feeling. mSystems 5(4):e00453\u2013e00420. https:\/\/doi.org\/10.1128\/mSystems.00453-20","journal-title":"mSystems"},{"key":"2236_CR49","doi-asserted-by":"publisher","first-page":"256294","DOI":"10.1155\/2012\/256294","volume":"2012","author":"C Tikellis","year":"2012","unstructured":"Tikellis C, Thomas MC (2012) Angiotensin-converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease. Int J Pept 2012:256294. https:\/\/doi.org\/10.1155\/2012\/256294","journal-title":"Int J Pept"},{"issue":"1","key":"2236_CR50","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1186\/s13054-020-03120-0","volume":"24","author":"W Ni","year":"2020","unstructured":"Ni W, Yang X, Yang D, Bao J, Li R, Xiao Y, Hou C, Wang H et al (2020) Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19. Crit Care 24(1):422. https:\/\/doi.org\/10.1186\/s13054-020-03120-0","journal-title":"Crit Care"},{"issue":"1","key":"2236_CR51","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1161\/HYPERTENSIONAHA.120.15291","volume":"76","author":"AM South","year":"2020","unstructured":"South AM, Brady TM, Flynn JT (2020) ACE2 (angiotensin-converting enzyme 2), COVID-19, and ACE inhibitor and Ang II (angiotensin II) receptor blocker use during the pandemic. Hypertension 76(1):16\u201322. https:\/\/doi.org\/10.1161\/HYPERTENSIONAHA.120.15291","journal-title":"Hypertension"},{"issue":"1","key":"2236_CR52","doi-asserted-by":"publisher","first-page":"e000417","DOI":"10.1136\/bmjgast-2020-000417","volume":"7","author":"VC Suresh Kumar","year":"2020","unstructured":"Suresh Kumar VC, Mukherjee S, Harne PS, Subedi A, Ganapathy MK, Patthipati VS, Sapkota B (2020) Novelty in the gut: a systematic review and meta-analysis of the gastrointestinal manifestations of COVID-19. BMJ Open Gastroenterol 7(1):e000417. https:\/\/doi.org\/10.1136\/bmjgast-2020-000417","journal-title":"BMJ Open Gastroenterol"},{"issue":"6","key":"2236_CR53","doi-asserted-by":"publisher","first-page":"e2011335","DOI":"10.1001\/jamanetworkopen.2020.11335","volume":"3","author":"S Parasa","year":"2020","unstructured":"Parasa S, Desai M, Thoguluva Chandrasekar V, Patel HK, Kennedy KF, Roesch T, Spadaccini M, Colombo M et al (2020) Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019: a systematic review and meta-analysis. JAMA Netw Open 3(6):e2011335. https:\/\/doi.org\/10.1001\/jamanetworkopen.2020.11335","journal-title":"JAMA Netw Open"},{"key":"2236_CR54","doi-asserted-by":"publisher","unstructured":"Gu S, Chen Y, Wu Z, Chen Y, Gao H, Lv L, Guo F, Zhang X et al (2020) Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza. Clin Infect Dis. https:\/\/doi.org\/10.1093\/cid\/ciaa709","DOI":"10.1093\/cid\/ciaa709"},{"issue":"5","key":"2236_CR55","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/mds.28084","volume":"35","author":"A Lippi","year":"2020","unstructured":"Lippi A, Domingues R, Setz C, Outeiro TF, Krisko A (2020) SARS-CoV-2: at the crossroad between aging and neurodegeneration. Mov Disord 35(5):716\u2013720. https:\/\/doi.org\/10.1002\/mds.28084","journal-title":"Mov Disord"},{"issue":"18","key":"2236_CR56","doi-asserted-by":"publisher","first-page":"9279","DOI":"10.1128\/jvi.00659-06","volume":"80","author":"C-P Chan","year":"2006","unstructured":"Chan C-P, Siu K-L, Chin K-T, Yuen K-Y, Zheng B, Jin D-Y (2006) Modulation of the unfolded protein response by the severe acute respiratory syndrome coronavirus spike protein. J Virol 80(18):9279\u20139287. https:\/\/doi.org\/10.1128\/jvi.00659-06","journal-title":"J Virol"},{"issue":"3","key":"2236_CR57","doi-asserted-by":"publisher","first-page":"180249","DOI":"10.1098\/rsob.180249","volume":"9","author":"A Krisko","year":"2019","unstructured":"Krisko A, Radman M (2019) Protein damage, ageing and age-related diseases. Open Biol 9(3):180249. https:\/\/doi.org\/10.1098\/rsob.180249","journal-title":"Open Biol"},{"issue":"4","key":"2236_CR58","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1002\/da.22084","volume":"30","author":"AH Miller","year":"2013","unstructured":"Miller AH, Haroon E, Raison CL, Felger JC (2013) Cytokine targets in the brain: impact on neurotransmitters and neurocircuits. Depress Anxiety 30(4):297\u2013306. https:\/\/doi.org\/10.1002\/da.22084","journal-title":"Depress Anxiety"},{"issue":"1","key":"2236_CR59","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.virol.2004.08.011","volume":"329","author":"B Sainz Jr","year":"2004","unstructured":"Sainz B Jr, Mossel EC, Peters CJ, Garry RF (2004) Interferon-beta and interferon-gamma synergistically inhibit the replication of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). Virology 329(1):11\u201317. https:\/\/doi.org\/10.1016\/j.virol.2004.08.011","journal-title":"Virology"},{"issue":"3","key":"2236_CR60","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00401-015-1462-8","volume":"130","author":"W Scheper","year":"2015","unstructured":"Scheper W, Hoozemans JJM (2015) The unfolded protein response in neurodegenerative diseases: a neuropathological perspective. Acta Neuropathol 130(3):315\u2013331. https:\/\/doi.org\/10.1007\/s00401-015-1462-8","journal-title":"Acta Neuropathol"},{"key":"2236_CR61","doi-asserted-by":"publisher","unstructured":"Williams FM, Freydin M, Mangino M, Couvreur S, Visconti A, Bowyer RC, Le Roy CI, Falchi M, Sudre C, Davies R, Hammond C, Menni C, Steves C, Spector T (2020) Self-reported symptoms of COVID-19 including symptoms most predictive of SARS-CoV-2 infection, are heritable. medRxiv 2020.2004.2022.20072124. doi:https:\/\/doi.org\/10.1101\/2020.04.22.20072124","DOI":"10.1101\/2020.04.22.20072124"},{"key":"2236_CR62","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.redox.2017.10.014","volume":"14","author":"C Cheignon","year":"2018","unstructured":"Cheignon C, Tomas M, Bonnefont-Rousselot D, Faller P, Hureau C, Collin F (2018) Oxidative stress and the amyloid beta peptide in Alzheimer\u2019s disease. Redox Biol 14:450\u2013464. https:\/\/doi.org\/10.1016\/j.redox.2017.10.014","journal-title":"Redox Biol"},{"key":"2236_CR63","doi-asserted-by":"publisher","unstructured":"Atkins JL, Masoli JA, Delgado J, Pilling LC, Kuo C-LC, Kuchel G, Melzer D (2020) Preexisting comorbidities predicting severe COVID-19 in older adults in the UK Biobank Community Cohort. medRxiv 2020.2005.2006.20092700. doi:https:\/\/doi.org\/10.1101\/2020.05.06.20092700","DOI":"10.1101\/2020.05.06.20092700"},{"issue":"16","key":"2236_CR64","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","volume":"278","author":"LA Farrer","year":"1997","unstructured":"Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA et al (1997) Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. Jama 278(16):1349\u20131356","journal-title":"Jama"},{"issue":"5","key":"2236_CR65","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.mayocp.2016.12.020","volume":"92","author":"CJ Jivanji","year":"2017","unstructured":"Jivanji CJ, Asrani VM, Windsor JA, Petrov MS (2017) New-onset diabetes after acute and critical illness: a systematic review. Mayo Clin Proc 92(5):762\u2013773. https:\/\/doi.org\/10.1016\/j.mayocp.2016.12.020","journal-title":"Mayo Clin Proc"},{"key":"2236_CR66","doi-asserted-by":"publisher","unstructured":"Kuo CL, Pilling LC, Atkins JL, Masoli JAH, Delgado J, Kuchel GA, Melzer D (2020) APOE e4 genotype predicts severe COVID-19 in the UK Biobank community cohort. J Gerontol A Biol Sci Med Sci. https:\/\/doi.org\/10.1093\/gerona\/glaa131","DOI":"10.1093\/gerona\/glaa131"},{"issue":"3","key":"2236_CR67","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/s00592-009-0109-4","volume":"47","author":"JK Yang","year":"2010","unstructured":"Yang JK, Lin SS, Ji XJ, Guo LM (2010) Binding of SARS coronavirus to its receptor damages islets and causes acute diabetes. Acta Diabetol 47(3):193\u2013199. https:\/\/doi.org\/10.1007\/s00592-009-0109-4","journal-title":"Acta Diabetol"},{"issue":"1","key":"2236_CR68","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13195-016-0217-7","volume":"8","author":"PG Kehoe","year":"2016","unstructured":"Kehoe PG, Wong S, Al Mulhim N, Palmer LE, Miners JS (2016) Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-\u03b2 and tau pathology. Alzheimers Res Ther 8(1):50. https:\/\/doi.org\/10.1186\/s13195-016-0217-7","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"2236_CR69","doi-asserted-by":"publisher","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","volume":"53","author":"T Jiang","year":"2016","unstructured":"Jiang T, Zhang YD, Zhou JS, Zhu XC, Tian YY, Zhao HD, Lu H, Gao Q et al (2016) Angiotensin-(1-7) is reduced and inversely correlates with tau hyperphosphorylation in animal models of Alzheimer\u2019s disease. Mol Neurobiol 53(4):2489\u20132497. https:\/\/doi.org\/10.1007\/s12035-015-9260-9","journal-title":"Mol Neurobiol"},{"key":"2236_CR70","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1186\/s12991-017-0164-0","volume":"16","author":"N Fekih-Mrissa","year":"2017","unstructured":"Fekih-Mrissa N, Bedoui I, Sayeh A, Derbali H, Mrad M, Mrissa R, Nsiri B (2017) Association between an angiotensin-converting enzyme gene polymorphism and Alzheimer\u2019s disease in a Tunisian population. Ann General Psychiatry 16:41. https:\/\/doi.org\/10.1186\/s12991-017-0164-0","journal-title":"Ann General Psychiatry"},{"key":"2236_CR71","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/j.neuroscience.2020.08.004","volume":"446","author":"Y-Q Yan","year":"2020","unstructured":"Yan Y-Q, Fang Y, Zheng R, Pu J-L, Zhang B-R (2020) NLRP3 Inflammasomes in Parkinson\u2019s disease and their regulation by Parkin. Neuroscience 446:323\u2013334. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.08.004","journal-title":"Neuroscience"},{"key":"2236_CR72","doi-asserted-by":"publisher","unstructured":"Corr\u00eaa DG, de Souza Lima FC, da Cruz BD, Coutinho AC, Hygino da Cruz LC (2020) COVID-19 associated with encephalomyeloradiculitis and positive anti-aquaporin-4 antibodies: cause or coincidence? Mult Scler J. https:\/\/doi.org\/10.1177\/1352458520949988","DOI":"10.1177\/1352458520949988"},{"issue":"10","key":"2236_CR73","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.1161\/CIRCRESAHA.120.317015","volume":"126","author":"M Gheblawi","year":"2020","unstructured":"Gheblawi M, Wang K, Viveiros A, Nguyen Q, Zhong J-C, Turner AJ, Raizada MK, Grant MB et al (2020) Angiotensin-converting enzyme 2: SARS-CoV-2 receptor and regulator of the renin-angiotensin system. Circ Res 126(10):1456\u20131474. https:\/\/doi.org\/10.1161\/CIRCRESAHA.120.317015","journal-title":"Circ Res"},{"issue":"16","key":"2236_CR74","doi-asserted-by":"publisher","first-page":"8722","DOI":"10.1128\/jvi.00253-07","volume":"81","author":"Y Inoue","year":"2007","unstructured":"Inoue Y, Tanaka N, Tanaka Y, Inoue S, Morita K, Zhuang M, Hattori T, Sugamura K (2007) Clathrin-dependent entry of severe acute respiratory syndrome coronavirus into target cells expressing ACE2 with the cytoplasmic tail deleted. J Virol 81(16):8722\u20138729. https:\/\/doi.org\/10.1128\/jvi.00253-07","journal-title":"J Virol"},{"key":"2236_CR75","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.neuroscience.2020.04.044","volume":"437","author":"XY Mao","year":"2020","unstructured":"Mao XY, Jin WL (2020) The COVID-19 pandemic: consideration for brain infection. Neuroscience 437:130\u2013131. https:\/\/doi.org\/10.1016\/j.neuroscience.2020.04.044","journal-title":"Neuroscience"},{"key":"2236_CR76","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.genhosppsych.2020.05.008","volume":"65","author":"SR Beach","year":"2020","unstructured":"Beach SR, Praschan NC, Hogan C, Dotson S, Merideth F, Kontos N, Fricchione GL, Smith FA (2020) Delirium in COVID-19: a case series and exploration of potential mechanisms for central nervous system involvement. Gen Hosp Psychiatry 65:47\u201353. https:\/\/doi.org\/10.1016\/j.genhosppsych.2020.05.008","journal-title":"Gen Hosp Psychiatry"},{"issue":"10234","key":"2236_CR77","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1016\/S0140-6736(20)30937-5","volume":"395","author":"Z Varga","year":"2020","unstructured":"Varga Z, Flammer AJ, Steiger P, Haberecker M, Andermatt R, Zinkernagel AS, Mehra MR, Schuepbach RA et al (2020) Endothelial cell infection and endotheliitis in COVID-19. Lancet 395(10234):1417\u20131418. https:\/\/doi.org\/10.1016\/S0140-6736(20)30937-5","journal-title":"Lancet"},{"key":"2236_CR78","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.ijid.2020.03.062","volume":"94","author":"T Moriguchi","year":"2020","unstructured":"Moriguchi T, Harii N, Goto J, Harada D, Sugawara H, Takamino J, Ueno M, Sakata H et al (2020) A first case of meningitis\/encephalitis associated with SARS-coronavirus-2. Int J Infect Dis 94:55\u201358. https:\/\/doi.org\/10.1016\/j.ijid.2020.03.062","journal-title":"Int J Infect Dis"},{"key":"2236_CR79","doi-asserted-by":"publisher","unstructured":"Ed\u00e9n A, Kanberg N, Gostner J, Fuchs D, Hagberg L, Andersson L-M, Lindh M, Price RW, Zetterberg H, Gissl\u00e9n M (2020) CSF biomarkers in patients with COVID-19 and neurological symptoms. A case series https:\/\/doi.org\/10.1212\/WNL.0000000000010977","DOI":"10.1212\/WNL.0000000000010977"},{"key":"2236_CR80","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.bbi.2020.04.080","volume":"87","author":"M Bostanc\u0131kl\u0131o\u011flu","year":"2020","unstructured":"Bostanc\u0131kl\u0131o\u011flu M (2020) SARS-CoV2 entry and spread in the lymphatic drainage system of the brain. Brain Behav Immun 87:122\u2013123. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.080","journal-title":"Brain Behav Immun"},{"key":"2236_CR81","doi-asserted-by":"publisher","unstructured":"Bagheri SHR, Asghari AM, Farhadi M, Shamshiri AR, Kabir A, Kamrava SK, Jalessi M, Mohebbi A, Alizadeh R, Honarmand AA, Ghalehbaghi B, Salimi A (2020) Coincidence of COVID-19 epidemic and olfactory dysfunction outbreak. medRxiv:2020.2003.2023.20041889. doi:https:\/\/doi.org\/10.1101\/2020.03.23.20041889","DOI":"10.1101\/2020.03.23.20041889"},{"key":"2236_CR82","doi-asserted-by":"publisher","unstructured":"Eliezer M, Hamel A-L, Houdart E, Herman P, Housset J, Jourdaine C, Eloit C, Verillaud B et al (2020) Loss of smell in COVID-19 patients: MRI data reveals a transient edema of the olfactory clefts. Neurology. https:\/\/doi.org\/10.1212\/wnl.0000000000010806","DOI":"10.1212\/wnl.0000000000010806"},{"key":"2236_CR83","doi-asserted-by":"publisher","unstructured":"Chen R, Wang K, Yu J, Chen Z, Wen C, Xu Z (2020) The spatial and cell-type distribution of SARS-CoV-2 receptor ACE2 in human and mouse brain. bioRxiv:2020.2004.2007.030650. doi:https:\/\/doi.org\/10.1101\/2020.04.07.030650","DOI":"10.1101\/2020.04.07.030650"},{"key":"2236_CR84","doi-asserted-by":"publisher","unstructured":"Shiers S, Ray PR, Wangzhou A, Tatsui CE, Rhines L, Li Y, Uhelski ML, Dougherty PM, Price TJ (2020) ACE2 expression in human dorsal root ganglion sensory neurons: implications for SARS-CoV-2 virus-induced neurological effects. bioRxiv:2020.2005.2028.122374. doi:https:\/\/doi.org\/10.1101\/2020.05.28.122374","DOI":"10.1101\/2020.05.28.122374"},{"key":"2236_CR85","doi-asserted-by":"publisher","unstructured":"Costello F, Dalakas MC (2020) Cranial neuropathies and COVID-19: neurotropism and autoimmunity. Neurology. https:\/\/doi.org\/10.1212\/WNL.0000000000009921","DOI":"10.1212\/WNL.0000000000009921"},{"key":"2236_CR86","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.bbi.2020.04.060","volume":"87","author":"G Esposito","year":"2020","unstructured":"Esposito G, Pesce M, Seguella L, Sanseverino W, Lu J, Sarnelli G (2020) Can the enteric nervous system be an alternative entrance door in SARS-CoV2 neuroinvasion? Brain Behav Immun 87:93\u201394. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.060","journal-title":"Brain Behav Immun"},{"key":"2236_CR87","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fneur.2017.00037","volume":"8","author":"CD Rietdijk","year":"2017","unstructured":"Rietdijk CD, Perez-Pardo P, Garssen J, van Wezel RJ, Kraneveld AD (2017) Exploring Braak\u2019s hypothesis of Parkinson\u2019s disease. Front Neurol 8:37. https:\/\/doi.org\/10.3389\/fneur.2017.00037","journal-title":"Front Neurol"},{"issue":"7","key":"2236_CR88","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1002\/jmv.25915","volume":"92","author":"A Paniz-Mondolfi","year":"2020","unstructured":"Paniz-Mondolfi A, Bryce C, Grimes Z, Gordon RE, Reidy J, Lednicky J, Sordillo EM, Fowkes M (2020) Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). J Med Virol 92(7):699\u2013702. https:\/\/doi.org\/10.1002\/jmv.25915","journal-title":"J Med Virol"},{"issue":"15","key":"2236_CR89","doi-asserted-by":"publisher","first-page":"7264","DOI":"10.1128\/jvi.00737-08","volume":"82","author":"J Netland","year":"2008","unstructured":"Netland J, Meyerholz DK, Moore S, Cassell M, Perlman S (2008) Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2. J Virol 82(15):7264\u20137275. https:\/\/doi.org\/10.1128\/jvi.00737-08","journal-title":"J Virol"},{"key":"2236_CR90","doi-asserted-by":"publisher","unstructured":"Ye M, Ren Y, Lv T (2020) Encephalitis as a clinical manifestation of COVID-19. Brain Behav Immun. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.017","DOI":"10.1016\/j.bbi.2020.04.017"},{"key":"2236_CR91","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbi.2020.04.024","volume":"87","author":"L Duong","year":"2020","unstructured":"Duong L, Xu P, Liu A (2020) Meningoencephalitis without respiratory failure in a young female patient with COVID-19 infection in Downtown Los Angeles, early April 2020. Brain Behav Immun 87:33. https:\/\/doi.org\/10.1016\/j.bbi.2020.04.024","journal-title":"Brain Behav Immun"},{"issue":"10223","key":"2236_CR92","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/s0140-6736(20)30183-5","volume":"395","author":"C Huang","year":"2020","unstructured":"Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, Zhang L, Fan G et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 395(10223):497\u2013506. https:\/\/doi.org\/10.1016\/s0140-6736(20)30183-5","journal-title":"Lancet"},{"issue":"9","key":"2236_CR93","doi-asserted-by":"publisher","first-page":"2016","DOI":"10.3201\/eid2609.202122","volume":"26","author":"K Benameur","year":"2020","unstructured":"Benameur K, Agarwal A, Auld S, Butters M, Webster A, Ozturk T, Howell JC, Bassit L et al (2020) Encephalopathy and encephalitis associated with cerebrospinal fluid cytokine alterations and coronavirus disease, Atlanta, Georgia, USA, 2020. Emerg Infect Dis J 26(9):2016\u20132021. https:\/\/doi.org\/10.3201\/eid2609.202122","journal-title":"Emerg Infect Dis J"},{"issue":"11","key":"2236_CR94","first-page":"18","volume":"6","author":"A Yarlagadda","year":"2009","unstructured":"Yarlagadda A, Alfson E, Clayton AH (2009) The blood brain barrier and the role of cytokines in neuropsychiatry. Psychiatry (Edgmont) 6(11):18\u201322","journal-title":"Psychiatry (Edgmont)"},{"key":"2236_CR95","doi-asserted-by":"publisher","first-page":"898192","DOI":"10.1155\/2015\/898192","volume":"2015","author":"M Dufek","year":"2015","unstructured":"Dufek M, Rektorova I, Thon V, Lokaj J, Rektor I (2015) Interleukin-6 may contribute to mortality in Parkinson\u2019s disease patients: a 4-year prospective study. Parkinson Disease 2015:898192. https:\/\/doi.org\/10.1155\/2015\/898192","journal-title":"Parkinson Disease"},{"issue":"2","key":"2236_CR96","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1111\/ene.12443","volume":"22","author":"A Lindlau","year":"2015","unstructured":"Lindlau A, Widmann CN, Putensen C, Jessen F, Semmler A, Heneka MT (2015) Predictors of hippocampal atrophy in critically ill patients. Eur J Neurol 22(2):410\u2013415. https:\/\/doi.org\/10.1111\/ene.12443","journal-title":"Eur J Neurol"},{"issue":"1","key":"2236_CR97","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13195-020-00640-3","volume":"12","author":"MT Heneka","year":"2020","unstructured":"Heneka MT, Golenbock D, Latz E, Morgan D, Brown R (2020) Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimers Res Ther 12(1):69. https:\/\/doi.org\/10.1186\/s13195-020-00640-3","journal-title":"Alzheimers Res Ther"},{"issue":"8","key":"2236_CR98","doi-asserted-by":"publisher","first-page":"870","DOI":"10.2174\/1567205014666170317113606","volume":"14","author":"C Domingues","year":"2017","unstructured":"Domingues C, da Cruz ESOAB, Henriques AG (2017) Impact of cytokines and chemokines on Alzheimer\u2019s disease neuropathological hallmarks. Curr Alzheimer Res 14(8):870\u2013882. https:\/\/doi.org\/10.2174\/1567205014666170317113606","journal-title":"Curr Alzheimer Res"},{"issue":"4","key":"2236_CR99","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1172\/jci133737","volume":"130","author":"ER Roy","year":"2020","unstructured":"Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y et al (2020) Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest 130(4):1912\u20131930. https:\/\/doi.org\/10.1172\/jci133737","journal-title":"J Clin Invest"},{"issue":"2","key":"2236_CR100","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1165\/rcmb.2013-0087OC","volume":"50","author":"HD Jones","year":"2014","unstructured":"Jones HD, Crother TR, Gonzalez-Villalobos RA, Jupelli M, Chen S, Dagvadorj J, Arditi M, Shimada K (2014) The NLRP3 inflammasome is required for the development of hypoxemia in LPS\/mechanical ventilation acute lung injury. Am J Respir Cell Mol Biol 50(2):270\u2013280. https:\/\/doi.org\/10.1165\/rcmb.2013-0087OC","journal-title":"Am J Respir Cell Mol Biol"},{"key":"2236_CR101","doi-asserted-by":"publisher","first-page":"102377","DOI":"10.1016\/j.msard.2020.102377","volume":"45","author":"M Palao","year":"2020","unstructured":"Palao M, Fern\u00e1ndez-D\u00edaz E, Gracia-Gil J, Romero-S\u00e1nchez CM, D\u00edaz-Maroto I, Segura T (2020) Multiple sclerosis following SARS-CoV-2 infection. Mult Scler Relat Disord 45:102377. https:\/\/doi.org\/10.1016\/j.msard.2020.102377","journal-title":"Mult Scler Relat Disord"},{"issue":"2","key":"2236_CR102","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/mds.870070210","volume":"7","author":"E Fazzini","year":"1992","unstructured":"Fazzini E, Fleming J, Fahn S (1992) Cerebrospinal fluid antibodies to coronavirus in patients with Parkinson\u2019s disease. Mov Disord 7(2):153\u2013158. https:\/\/doi.org\/10.1002\/mds.870070210","journal-title":"Mov Disord"},{"key":"2236_CR103","doi-asserted-by":"publisher","unstructured":"Desforges M, Le Coupanec A, Dubeau P, Bourgouin A, Lajoie L, Dub\u00e9 M, Talbot PJ (2019) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12(1). https:\/\/doi.org\/10.3390\/v12010014","DOI":"10.3390\/v12010014"},{"issue":"6","key":"2236_CR104","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","volume":"20","author":"M Merad","year":"2020","unstructured":"Merad M, Martin JC (2020) Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages. Nat Rev Immunol 20(6):355\u2013362. https:\/\/doi.org\/10.1038\/s41577-020-0331-4","journal-title":"Nat Rev Immunol"},{"key":"2236_CR105","doi-asserted-by":"publisher","first-page":"697","DOI":"10.3389\/fimmu.2018.00697","volume":"9","author":"L Sevenich","year":"2018","unstructured":"Sevenich L (2018) Brain-resident microglia and blood-borne macrophages orchestrate central nervous system inflammation in neurodegenerative disorders and brain cancer. Front Immunol 9:697. https:\/\/doi.org\/10.3389\/fimmu.2018.00697","journal-title":"Front Immunol"},{"issue":"1-2","key":"2236_CR106","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/j.virusres.2007.06.016","volume":"130","author":"M Desforges","year":"2007","unstructured":"Desforges M, Miletti TC, Gagnon M, Talbot PJ (2007) Activation of human monocytes after infection by human coronavirus 229E. Virus Res 130(1-2):228\u2013240. https:\/\/doi.org\/10.1016\/j.virusres.2007.06.016","journal-title":"Virus Res"},{"issue":"7821","key":"2236_CR107","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41586-020-2550-z","volume":"584","author":"N Le Bert","year":"2020","unstructured":"Le Bert N, Tan AT, Kunasegaran K, Tham CYL, Hafezi M, Chia A, Chng MHY, Lin M et al (2020) SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls. Nature 584(7821):457\u2013462. https:\/\/doi.org\/10.1038\/s41586-020-2550-z","journal-title":"Nature"},{"key":"2236_CR108","doi-asserted-by":"publisher","unstructured":"Swadling L, Maini MK (2020) T cells in COVID-19\u2014united in diversity. Nat Immunol. https:\/\/doi.org\/10.1038\/s41590-020-0798-y","DOI":"10.1038\/s41590-020-0798-y"},{"issue":"1","key":"2236_CR109","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1172\/jci36470","volume":"119","author":"V Brochard","year":"2009","unstructured":"Brochard V, Combadi\u00e8re B, Prigent A, Laouar Y, Perrin A, Beray-Berthat V, Bonduelle O, Alvarez-Fischer D et al (2009) Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease. J Clin Invest 119(1):182\u2013192. https:\/\/doi.org\/10.1172\/jci36470","journal-title":"J Clin Invest"},{"issue":"10","key":"2236_CR110","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1007\/s13238-020-00762-2","volume":"11","author":"Y Zheng","year":"2020","unstructured":"Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S et al (2020) A human circulating immune cell landscape in aging and COVID-19. Protein Cell 11(10):740\u2013770. https:\/\/doi.org\/10.1007\/s13238-020-00762-2","journal-title":"Protein Cell"},{"key":"2236_CR111","doi-asserted-by":"publisher","first-page":"560","DOI":"10.3389\/fneur.2018.00560","volume":"9","author":"M Dolatshahi","year":"2018","unstructured":"Dolatshahi M, Pourmirbabaei S, Kamalian A, Ashraf-Ganjouei A, Yaseri M, Aarabi MH (2018) Longitudinal alterations of alpha-synuclein, amyloid beta, total, and phosphorylated tau in cerebrospinal fluid and correlations between their changes in Parkinson\u2019s disease. Front Neurol 9:560","journal-title":"Front Neurol"},{"issue":"6","key":"2236_CR112","doi-asserted-by":"publisher","first-page":"3080","DOI":"10.4049\/jimmunol.1303196","volume":"193","author":"CS Shi","year":"2014","unstructured":"Shi CS, Qi HY, Boularan C, Huang NN, Abu-Asab M, Shelhamer JH, Kehrl JH (2014) SARS-coronavirus open reading frame-9b suppresses innate immunity by targeting mitochondria and the MAVS\/TRAF3\/TRAF6 signalosome. J Immunol 193(6):3080\u20133089. https:\/\/doi.org\/10.4049\/jimmunol.1303196","journal-title":"J Immunol"},{"issue":"12","key":"2236_CR113","doi-asserted-by":"publisher","first-page":"1383","DOI":"10.1016\/j.bbagen.2008.07.009","volume":"1780","author":"Z Ye","year":"2008","unstructured":"Ye Z, Wong CK, Li P, Xie Y (2008) A SARS-CoV protein, ORF-6, induces caspase-3 mediated, ER stress and JNK-dependent apoptosis. Biochim Biophys Acta 1780(12):1383\u20131387. https:\/\/doi.org\/10.1016\/j.bbagen.2008.07.009","journal-title":"Biochim Biophys Acta"},{"key":"2236_CR114","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.3389\/fphar.2020.01095","volume":"11","author":"T Aoe","year":"2020","unstructured":"Aoe T (2020) Pathological aspects of COVID-19 as a conformational disease and the use of pharmacological chaperones as a potential therapeutic strategy. Front Pharmacol 11:1095. https:\/\/doi.org\/10.3389\/fphar.2020.01095","journal-title":"Front Pharmacol"},{"key":"2236_CR115","doi-asserted-by":"publisher","first-page":"173288","DOI":"10.1016\/j.ejphar.2020.173288","volume":"882","author":"A Sureda","year":"2020","unstructured":"Sureda A, Alizadeh J, Nabavi SF, Berindan-Neagoe I, Cismaru CA, Jeandet P, \u0141os MJ, Clementi E et al (2020) Endoplasmic reticulum as a potential therapeutic target for COVID-19 infection management? Eur J Pharmacol 882:173288. https:\/\/doi.org\/10.1016\/j.ejphar.2020.173288","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"2236_CR116","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1111\/cns.13116","volume":"25","author":"Y Wang","year":"2019","unstructured":"Wang Y, Xu E, Musich PR, Lin F (2019) Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure. CNS Neurosci Ther 25(7):816\u2013824. https:\/\/doi.org\/10.1111\/cns.13116","journal-title":"CNS Neurosci Ther"},{"key":"2236_CR117","doi-asserted-by":"publisher","unstructured":"Zhang H, Liao YS, Gong J, Liu J, Xia X, Zhang H (2020) Clinical characteristics of coronavirus disease (COVID-19) patients with gastrointestinal symptoms: a report of 164 cases. Dig Liver Dis. https:\/\/doi.org\/10.1016\/j.dld.2020.04.034","DOI":"10.1016\/j.dld.2020.04.034"},{"key":"2236_CR118","doi-asserted-by":"publisher","unstructured":"Zuo T, Zhang F, Lui GCY, Yeoh YK, Li AYL, Zhan H, Wan Y, Chung A et al (2020) Alterations in gut microbiota of patients with COVID-19 during time of hospitalization. Gastroenterology. https:\/\/doi.org\/10.1053\/j.gastro.2020.05.048","DOI":"10.1053\/j.gastro.2020.05.048"},{"key":"2236_CR119","doi-asserted-by":"publisher","first-page":"130","DOI":"10.3389\/fnagi.2019.00130","volume":"11","author":"YM Ambrosini","year":"2019","unstructured":"Ambrosini YM, Borcherding D, Kanthasamy A, Kim HJ, Willette AA, Jergens A, Allenspach K, Mochel JP (2019) The gut-brain axis in neurodegenerative diseases and relevance of the canine model: a review. Front Aging Neurosci 11:130. https:\/\/doi.org\/10.3389\/fnagi.2019.00130","journal-title":"Front Aging Neurosci"},{"key":"2236_CR120","doi-asserted-by":"publisher","first-page":"198018","DOI":"10.1016\/j.virusres.2020.198018","volume":"285","author":"D Dhar","year":"2020","unstructured":"Dhar D, Mohanty A (2020) Gut microbiota and Covid-19-possible link and implications. Virus Res 285:198018. https:\/\/doi.org\/10.1016\/j.virusres.2020.198018","journal-title":"Virus Res"},{"issue":"3","key":"2236_CR121","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/j.sjbs.2020.01.026","volume":"27","author":"OA Abiodun","year":"2020","unstructured":"Abiodun OA, Ola MS (2020) Role of brain renin angiotensin system in neurodegeneration: An update. Saudi J Biol Sci 27(3):905\u2013912. https:\/\/doi.org\/10.1016\/j.sjbs.2020.01.026","journal-title":"Saudi J Biol Sci"},{"key":"2236_CR122","doi-asserted-by":"publisher","unstructured":"Nataf S (2020) An alteration of the dopamine synthetic pathway is possibly involved in the pathophysiology of COVID-19. J Med Virol. https:\/\/doi.org\/10.1002\/jmv.25826","DOI":"10.1002\/jmv.25826"},{"key":"2236_CR123","doi-asserted-by":"publisher","unstructured":"Benetti E, Tita R, Spiga O, Ciolfi A, Birolo G, Bruselles A, Doddato G, Giliberti A et al (2020) ACE2 gene variants may underlie interindividual variability and susceptibility to COVID-19 in the Italian population. Eur J Hum Genet. https:\/\/doi.org\/10.1038\/s41431-020-0691-z","DOI":"10.1038\/s41431-020-0691-z"},{"issue":"3","key":"2236_CR124","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/j.jmii.2020.04.015","volume":"53","author":"CA Devaux","year":"2020","unstructured":"Devaux CA, Rolain J-M, Raoult D (2020) ACE2 receptor polymorphism: Susceptibility to SARS-CoV-2, hypertension, multi-organ failure, and COVID-19 disease outcome. J Microbiol Immunol Infect 53(3):425\u2013435. https:\/\/doi.org\/10.1016\/j.jmii.2020.04.015","journal-title":"J Microbiol Immunol Infect"},{"issue":"1-2","key":"2236_CR125","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/s0022-510x(02)00081-3","volume":"199","author":"JJ Lin","year":"2002","unstructured":"Lin JJ, Yueh KC, Chang DC, Lin SZ (2002) Association between genetic polymorphism of angiotensin-converting enzyme gene and Parkinson\u2019s disease. J Neurol Sci 199(1-2):25\u201329. https:\/\/doi.org\/10.1016\/s0022-510x(02)00081-3","journal-title":"J Neurol Sci"},{"issue":"4","key":"2236_CR126","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1021\/cn500363g","volume":"6","author":"P Kaur","year":"2015","unstructured":"Kaur P, Muthuraman A, Kaur M (2015) The implications of angiotensin-converting enzymes and their modulators in neurodegenerative disorders: current and future perspectives. ACS Chem Neurosci 6(4):508\u2013521. https:\/\/doi.org\/10.1021\/cn500363g","journal-title":"ACS Chem Neurosci"},{"key":"2236_CR127","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ynstr.2018.08.009","volume":"9","author":"JA Sierra-Fonseca","year":"2018","unstructured":"Sierra-Fonseca JA, Gosselink KL (2018) Tauopathy and neurodegeneration: a role for stress. Neurobiol Stress 9:105\u2013112. https:\/\/doi.org\/10.1016\/j.ynstr.2018.08.009","journal-title":"Neurobiol Stress"},{"issue":"6","key":"2236_CR128","doi-asserted-by":"publisher","first-page":"445","DOI":"10.5455\/medarh.2016.70.445-448","volume":"70","author":"OC Ibrahimagic","year":"2016","unstructured":"Ibrahimagic OC, Jakubovic AC, Smajlovic D, Dostovic Z, Kunic S, Iljazovic A (2016) Psychological stress and changes of hypothalamic-pituitary-adrenal axis in patients with \u201cde novo\u201d Parkinson\u2019s disease. Mediev Archaeol 70(6):445\u2013448. https:\/\/doi.org\/10.5455\/medarh.2016.70.445-448","journal-title":"Mediev Archaeol"},{"issue":"1137","key":"2236_CR129","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1136\/postgradmedj-2020-137934","volume":"96","author":"S Agarwal","year":"2020","unstructured":"Agarwal S, Agarwal SK (2020) Endocrine changes in SARS-CoV-2 patients and lessons from SARS-CoV. Postgrad Med J 96(1137):412\u2013416. https:\/\/doi.org\/10.1136\/postgradmedj-2020-137934","journal-title":"Postgrad Med J"},{"issue":"7","key":"2236_CR130","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1111\/j.1365-2362.2009.02153.x","volume":"39","author":"GY Oudit","year":"2009","unstructured":"Oudit GY, Kassiri Z, Jiang C, Liu PP, Poutanen SM, Penninger JM, Butany J (2009) SARS-coronavirus modulation of myocardial ACE2 expression and inflammation in patients with SARS. Eur J Clin Investig 39(7):618\u2013625. https:\/\/doi.org\/10.1111\/j.1365-2362.2009.02153.x","journal-title":"Eur J Clin Investig"},{"issue":"8","key":"2236_CR131","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1038\/nm1267","volume":"11","author":"K Kuba","year":"2005","unstructured":"Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, Huan Y, Yang P et al (2005) A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus\u2013induced lung injury. Nat Med 11(8):875\u2013879. https:\/\/doi.org\/10.1038\/nm1267","journal-title":"Nat Med"},{"key":"2236_CR132","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.neuropharm.2018.01.025","volume":"133","author":"LA Wang","year":"2018","unstructured":"Wang LA, de Kloet AD, Smeltzer MD, Cahill KM, Hiller H, Bruce EB, Pioquinto DJ, Ludin JA et al (2018) Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice. Neuropharmacology 133:85\u201393. https:\/\/doi.org\/10.1016\/j.neuropharm.2018.01.025","journal-title":"Neuropharmacology"},{"key":"2236_CR133","doi-asserted-by":"publisher","unstructured":"Steenblock C, Todorov V, Kanczkowski W, Eisenhofer G, Schedl A, Wong M-L, Licinio J, Bauer M et al (2020) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the neuroendocrine stress axis. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-020-0758-9","DOI":"10.1038\/s41380-020-0758-9"},{"issue":"2","key":"2236_CR134","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1365-2265.2005.02325.x","volume":"63","author":"MK Leow","year":"2005","unstructured":"Leow MK, Kwek DS, Ng AW, Ong KC, Kaw GJ, Lee LS (2005) Hypocortisolism in survivors of severe acute respiratory syndrome (SARS). Clin Endocrinol 63(2):197\u2013202. https:\/\/doi.org\/10.1111\/j.1365-2265.2005.02325.x","journal-title":"Clin Endocrinol"},{"issue":"9","key":"2236_CR135","doi-asserted-by":"publisher","first-page":"6806","DOI":"10.1007\/s12035-016-0170-2","volume":"54","author":"G Morris","year":"2017","unstructured":"Morris G, Anderson G, Maes M (2017) Hypothalamic-pituitary-adrenal hypofunction in myalgic encephalomyelitis (ME)\/chronic fatigue syndrome (CFS) as a consequence of activated immune-inflammatory and oxidative and nitrosative pathways. Mol Neurobiol 54(9):6806\u20136819. https:\/\/doi.org\/10.1007\/s12035-016-0170-2","journal-title":"Mol Neurobiol"},{"issue":"11","key":"2236_CR136","doi-asserted-by":"publisher","first-page":"1954","DOI":"10.7150\/ijbs.46891","volume":"16","author":"W Chen","year":"2020","unstructured":"Chen W (2020) A potential treatment of COVID-19 with TGF-\u03b2 blockade. Int J Biol Sci 16(11):1954\u20131955. https:\/\/doi.org\/10.7150\/ijbs.46891","journal-title":"Int J Biol Sci"},{"key":"2236_CR137","doi-asserted-by":"publisher","first-page":"101623","DOI":"10.1016\/j.tmaid.2020.101623","volume":"34","author":"AJ Rodriguez-Morales","year":"2020","unstructured":"Rodriguez-Morales AJ, Cardona-Ospina JA, Guti\u00e9rrez-Ocampo E, Villamizar-Pe\u00f1a R, Holguin-Rivera Y, Escalera-Antezana JP, Alvarado-Arnez LE, Bonilla-Aldana DK et al (2020) Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis 34:101623. https:\/\/doi.org\/10.1016\/j.tmaid.2020.101623","journal-title":"Travel Med Infect Dis"},{"issue":"1","key":"2236_CR138","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13054-019-2626-z","volume":"23","author":"C Sasannejad","year":"2019","unstructured":"Sasannejad C, Ely EW, Lahiri S (2019) Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care 23(1):352. https:\/\/doi.org\/10.1186\/s13054-019-2626-z","journal-title":"Crit Care"},{"key":"2236_CR139","doi-asserted-by":"publisher","unstructured":"Kanberg N, Ashton NJ, Andersson LM, Yilmaz A, Lindh M, Nilsson S, Price RW, Blennow K et al (2020) Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19. Neurology. https:\/\/doi.org\/10.1212\/wnl.0000000000010111","DOI":"10.1212\/wnl.0000000000010111"},{"issue":"4","key":"2236_CR140","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1097\/00000542-200504000-00011","volume":"102","author":"M Fries","year":"2005","unstructured":"Fries M, Bickenbach J, Henzler D, Beckers S, Dembinski R, Sellhaus B, Rossaint R, Kuhlen R (2005) S-100 protein and neurohistopathologic changes in a porcine model of acute lung injury. Anesthesiology 102(4):761\u2013767. https:\/\/doi.org\/10.1097\/00000542-200504000-00011","journal-title":"Anesthesiology"},{"issue":"10","key":"2236_CR141","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1038\/jcbfm.2013.135","volume":"33","author":"MA Erickson","year":"2013","unstructured":"Erickson MA, Banks WA (2013) Blood-brain barrier dysfunction as a cause and consequence of Alzheimer\u2019s disease. J Cereb Blood Flow Metab 33(10):1500\u20131513. https:\/\/doi.org\/10.1038\/jcbfm.2013.135","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"2236_CR142","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/2110-5820-3-15","volume":"3","author":"R Sonneville","year":"2013","unstructured":"Sonneville R, Verdonk F, Rauturier C, Klein IF, Wolff M, Annane D, Chretien F, Sharshar T (2013) Understanding brain dysfunction in sepsis. Ann Intensive Care 3(1):15. https:\/\/doi.org\/10.1186\/2110-5820-3-15","journal-title":"Ann Intensive Care"},{"issue":"1","key":"2236_CR143","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s12028-009-9289-6","volume":"12","author":"FS Taccone","year":"2010","unstructured":"Taccone FS, Castanares-Zapatero D, Peres-Bota D, Vincent JL, Berre J, Melot C (2010) Cerebral autoregulation is influenced by carbon dioxide levels in patients with septic shock. Neurocrit Care 12(1):35\u201342. https:\/\/doi.org\/10.1007\/s12028-009-9289-6","journal-title":"Neurocrit Care"},{"issue":"3","key":"2236_CR144","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1007\/s12975-020-00818-9","volume":"11","author":"DC Hess","year":"2020","unstructured":"Hess DC, Eldahshan W, Rutkowski E (2020) COVID-19-related stroke. Transl Stroke Res 11(3):322\u2013325. https:\/\/doi.org\/10.1007\/s12975-020-00818-9","journal-title":"Transl Stroke Res"},{"key":"2236_CR145","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.thromres.2020.04.041","volume":"191","author":"FA Klok","year":"2020","unstructured":"Klok FA, Kruip M, van der Meer NJM, Arbous MS, Gommers D, Kant KM, Kaptein FHJ, van Paassen J et al (2020) Confirmation of the high cumulative incidence of thrombotic complications in critically ill ICU patients with COVID-19: An updated analysis. Thromb Res 191:148\u2013150. https:\/\/doi.org\/10.1016\/j.thromres.2020.04.041","journal-title":"Thromb Res"},{"issue":"4","key":"2236_CR146","doi-asserted-by":"publisher","first-page":"R804","DOI":"10.1152\/ajpregu.00222.2010","volume":"300","author":"P Xu","year":"2011","unstructured":"Xu P, Sriramula S, Lazartigues E (2011) ACE2\/ANG-(1\u20137)\/Mas pathway in the brain: the axis of good. Am J Phys Regul Integr Comp Phys 300(4):R804\u2013R817. https:\/\/doi.org\/10.1152\/ajpregu.00222.2010","journal-title":"Am J Phys Regul Integr Comp Phys"},{"issue":"6","key":"2236_CR147","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1093\/jnen\/nly024","volume":"77","author":"O Scudamore","year":"2018","unstructured":"Scudamore O, Ciossek T (2018) Increased oxidative stress exacerbates \u03b1-synuclein aggregation in vivo. J Neuropathol Exp Neurol 77(6):443\u2013453. https:\/\/doi.org\/10.1093\/jnen\/nly024","journal-title":"J Neuropathol Exp Neurol"},{"key":"2236_CR148","doi-asserted-by":"publisher","unstructured":"Goldstein MR, Poland GA, Graeber WC (2020) Does apolipoprotein E genotype predict COVID-19 severity? QJM: an International Journal of Medicine. https:\/\/doi.org\/10.1093\/qjmed\/hcaa142","DOI":"10.1093\/qjmed\/hcaa142"},{"key":"2236_CR149","doi-asserted-by":"publisher","unstructured":"Wang H, Yuan Z, Pavel MA, Hansen SB (2020) The role of high cholesterol in age-related COVID19 lethality. bioRxiv. https:\/\/doi.org\/10.1101\/2020.05.09.086249","DOI":"10.1101\/2020.05.09.086249"},{"key":"2236_CR150","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.jsbmb.2016.03.012","volume":"160","author":"BC Riedel","year":"2016","unstructured":"Riedel BC, Thompson PM, Brinton RD (2016) Age, APOE and sex: triad of risk of Alzheimer\u2019s disease. J Steroid Biochem Mol Biol 160:134\u2013147. https:\/\/doi.org\/10.1016\/j.jsbmb.2016.03.012","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"1","key":"2236_CR151","doi-asserted-by":"publisher","first-page":"9110","DOI":"10.1038\/s41598-017-09536-z","volume":"7","author":"Q Wu","year":"2017","unstructured":"Wu Q, Zhou L, Sun X, Yan Z, Hu C, Wu J, Xu L, Li X et al (2017) Altered lipid metabolism in recovered SARS patients twelve years after infection. Sci Rep 7(1):9110. https:\/\/doi.org\/10.1038\/s41598-017-09536-z","journal-title":"Sci Rep"},{"issue":"5","key":"2236_CR152","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1097\/ccm.0000000000001621","volume":"44","author":"M Huang","year":"2016","unstructured":"Huang M, Parker AM, Bienvenu OJ, Dinglas VD, Colantuoni E, Hopkins RO, Needham DM (2016) psychiatric symptoms in acute respiratory distress syndrome survivors: a 1-year national multicenter study. Crit Care Med 44(5):954\u2013965. https:\/\/doi.org\/10.1097\/ccm.0000000000001621","journal-title":"Crit Care Med"},{"issue":"1","key":"2236_CR153","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s13679-018-0296-9","volume":"7","author":"S Higgs","year":"2018","unstructured":"Higgs S, Spetter MS (2018) Cognitive Control of eating: the role of memory in appetite and weight gain. Curr Obes Rep 7(1):50\u201359. https:\/\/doi.org\/10.1007\/s13679-018-0296-9","journal-title":"Curr Obes Rep"},{"issue":"1","key":"2236_CR154","doi-asserted-by":"publisher","first-page":"5","DOI":"10.2174\/156720512799015064","volume":"9","author":"H Cai","year":"2012","unstructured":"Cai H, Cong WN, Ji S, Rothman S, Maudsley S, Martin B (2012) Metabolic dysfunction in Alzheimer\u2019s disease and related neurodegenerative disorders. Curr Alzheimer Res 9(1):5\u201317. https:\/\/doi.org\/10.2174\/156720512799015064","journal-title":"Curr Alzheimer Res"},{"key":"2236_CR155","doi-asserted-by":"publisher","unstructured":"Kang Z, Luo S, Gui Y, Zhou H, Zhang Z, Tian C, Zhou Q, Wang Q et al (2020) Obesity is a potential risk factor contributing to clinical manifestations of COVID-19. Int J Obes. https:\/\/doi.org\/10.1038\/s41366-020-00677-2","DOI":"10.1038\/s41366-020-00677-2"},{"issue":"1","key":"2236_CR156","doi-asserted-by":"publisher","first-page":"E197","DOI":"10.1152\/ajpendo.00255.2020","volume":"319","author":"X Cao","year":"2020","unstructured":"Cao X, Yin R, Albrecht H, Fan D, Tan W (2020) Cholesterol: a new game player accelerating vasculopathy caused by SARS-CoV-2? Am J Physiol Endocrinol Metab 319(1):E197\u2013e202. https:\/\/doi.org\/10.1152\/ajpendo.00255.2020","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"2236_CR157","doi-asserted-by":"publisher","first-page":"284","DOI":"10.3390\/brainsci10050284","volume":"10","author":"CA Hribar","year":"2020","unstructured":"Hribar CA, Cobbold PH, Church FC (2020) Potential role of vitamin D in the elderly to resist COVID-19 and to slow progression of Parkinson\u2019s disease. Brain Sci 10(5):284. https:\/\/doi.org\/10.3390\/brainsci10050284","journal-title":"Brain Sci"}],"updated-by":[{"DOI":"10.1007\/s12035-021-02308-x","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000}}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02236-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-020-02236-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-020-02236-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T22:41:51Z","timestamp":1627684911000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-020-02236-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,8]]},"references-count":157,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["2236"],"URL":"https:\/\/doi.org\/10.1007\/s12035-020-02236-2","relation":{"correction":[{"id-type":"doi","id":"10.1007\/s12035-021-02308-x","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,8]]},"assertion":[{"value":"5 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 November 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 January 2021","order":4,"name":"change_date","label":"Change Date","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Correction","order":5,"name":"change_type","label":"Change Type","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"A Correction to this paper has been published:","order":6,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"https:\/\/doi.org\/10.1007\/s12035-021-02308-x","URL":"https:\/\/doi.org\/10.1007\/s12035-021-02308-x","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors declare their consent for publication","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}