{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:48:25Z","timestamp":1790884105214,"version":"4.1.0"},"reference-count":107,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T00:00:00Z","timestamp":1611360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871785,81672161"],"award-info":[{"award-number":["81871785,81672161"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12035-021-02289-x","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T16:03:21Z","timestamp":1611417801000},"page":"2643-2662","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Identification of Regeneration and Hub Genes and Pathways at Different Time Points after Spinal Cord Injury"],"prefix":"10.1007","volume":"58","author":[{"given":"Sheng","family":"Fang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-quan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7632-5088","authenticated-orcid":false,"given":"Zong-Sheng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,1,23]]},"reference":[{"key":"2289_CR1","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jot.2019.10.006","volume":"20","author":"H Huang","year":"2020","unstructured":"Huang H, Young W, Skaper S, Chen L, Moviglia G, Saberi H, al-Zoubi Z, Sharma HS et al (2020) Clinical neurorestorative therapeutic guidelines for spinal cord injury (IANR\/CANR version 2019). J Orthop Transl 20:14\u201324. https:\/\/doi.org\/10.1016\/j.jot.2019.10.006","journal-title":"J Orthop Transl"},{"key":"2289_CR2","doi-asserted-by":"publisher","unstructured":"Alizadeh A, Dyck SM, Karimi-Abdolrezaee S (2019) Traumatic spinal cord injury: an overview of pathophysiology. Models and Acute Injury Mechanisms Front Neurol 10. https:\/\/doi.org\/10.3389\/fneur.2019.00282","DOI":"10.3389\/fneur.2019.00282"},{"key":"2289_CR3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15252\/emmm.201911505","volume":"12","author":"JM Griffin","year":"2020","unstructured":"Griffin JM, Bradke F (2020) Therapeutic repair for spinal cord injury: Combinatory approaches to address a multifaceted problem. EMBO Mol med 12:1\u201329. https:\/\/doi.org\/10.15252\/emmm.201911505","journal-title":"EMBO Mol med"},{"key":"2289_CR4","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1089\/neu.2006.23.318","volume":"23","author":"DC Baptiste","year":"2006","unstructured":"Baptiste DC, Fehlings MG (2006) Pharmacological approaches to repair the injured spinal cord. J Neurotrauma 23:318\u2013334. https:\/\/doi.org\/10.1089\/neu.2006.23.318","journal-title":"J Neurotrauma"},{"key":"2289_CR5","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/s41593-020-0597-7","volume":"23","author":"X Zhou","year":"2020","unstructured":"Zhou X, Wahane S, Friedl MS, Kluge M, Friedel CC, Avrampou K, Zachariou V, Guo L et al (2020) Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2. Nat Neurosci 23:337\u2013350. https:\/\/doi.org\/10.1038\/s41593-020-0597-7","journal-title":"Nat Neurosci"},{"key":"2289_CR6","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s10753-020-01249-2","volume":"43","author":"C Zhaohui","year":"2020","unstructured":"Zhaohui C, Shuihua W (2020) Protective effects of SIRT6 against inflammation, oxidative stress, and cell apoptosis in spinal cord injury. Inflammation 43:1751\u20131758. https:\/\/doi.org\/10.1007\/s10753-020-01249-2","journal-title":"Inflammation"},{"key":"2289_CR7","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.bbrc.2019.07.125","volume":"517","author":"WY Yi","year":"2019","unstructured":"Yi WY, Shen D, Jun ZL et al (2019) Sting is a critical regulator of spinal cord injury by regulating microglial inflammation via interacting with TBK1 in mice. Biochem Biophys Res Commun 517:741\u2013748. https:\/\/doi.org\/10.1016\/j.bbrc.2019.07.125","journal-title":"Biochem Biophys Res Commun"},{"key":"2289_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nm.4451","volume":"24","author":"XJ Zhang","year":"2018","unstructured":"Zhang XJ, Cheng X, Yan ZZ, Fang J, Wang X, Wang W, Liu ZY, Shen LJ et al (2018) An ALOX12-12-HETE-GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury. Nat Med 24:73\u201383. https:\/\/doi.org\/10.1038\/nm.4451","journal-title":"Nat Med"},{"key":"2289_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/jid.2013.64","volume":"133","author":"J Villase\u00f1or-Park","year":"2013","unstructured":"Villase\u00f1or-Park J, Ortega-Loayza AG (2013) Microarray technique, analysis, and applications in dermatology. J Invest Dermatol 133:1\u20134. https:\/\/doi.org\/10.1038\/jid.2013.64","journal-title":"J Invest Dermatol"},{"key":"2289_CR10","doi-asserted-by":"publisher","unstructured":"Jeon J, Noh J, Lee H et al (2020) RIP3 axis perturbation accelerates osteoarthritis pathogenesis:1\u20139. https:\/\/doi.org\/10.1136\/annrheumdis-2020-217904","DOI":"10.1136\/annrheumdis-2020-217904"},{"key":"2289_CR11","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1016\/j.ebiom.2019.01.003","volume":"40","author":"Y Cheng","year":"2019","unstructured":"Cheng Y, Wang K, Geng L, Sun J, Xu W, Liu D, Gong S, Zhu Y (2019) Identification of candidate diagnostic and prognostic biomarkers for pancreatic carcinoma. EBioMedicine 40:382\u2013393. https:\/\/doi.org\/10.1016\/j.ebiom.2019.01.003","journal-title":"EBioMedicine"},{"key":"2289_CR12","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1158\/1078-0432.CCR-19-1543","volume":"26","author":"JM Karasinska","year":"2020","unstructured":"Karasinska JM, Topham JT, Kalloger SE, Jang GH, Denroche RE, Culibrk L, Williamson LM, Wong HL et al (2020) Altered gene expression along the glycolysis\u2013cholesterol synthesis axis is associated with outcome in pancreatic cancer. Clin Cancer Res 26:135\u2013146. https:\/\/doi.org\/10.1158\/1078-0432.CCR-19-1543","journal-title":"Clin Cancer Res"},{"key":"2289_CR13","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10020-019-0113-2","volume":"25","author":"YY Zhou","year":"2019","unstructured":"Zhou YY, Chen LP, Zhang Y, Hu SK, Dong ZJ, Wu M, Chen QX, Zhuang ZZ et al (2019) Integrated transcriptomic analysis reveals hub genes involved in diagnosis and prognosis of pancreatic cancer. Mol Med 25:1\u201313. https:\/\/doi.org\/10.1186\/s10020-019-0113-2","journal-title":"Mol Med"},{"key":"2289_CR14","doi-asserted-by":"publisher","first-page":"3528","DOI":"10.1158\/1078-0432.CCR-18-4085","volume":"25","author":"B Li","year":"2019","unstructured":"Li B, Cui Y, Nambiar DK, Sunwoo JB, Li R (2019) The immune subtypes and landscape of squamous cell carcinoma. Clin Cancer Res 25:3528\u20133537. https:\/\/doi.org\/10.1158\/1078-0432.CCR-18-4085","journal-title":"Clin Cancer Res"},{"key":"2289_CR15","doi-asserted-by":"crossref","unstructured":"Li Z, Yu F, Yu X, Wang S (2020) Potential molecular mechanism and biomarker investigation for spinal cord injury based on bioinformatics analysis 1:","DOI":"10.1007\/s12031-020-01549-0"},{"key":"2289_CR16","doi-asserted-by":"publisher","first-page":"1997","DOI":"10.3892\/mmr.2017.6267","volume":"15","author":"Z Yang","year":"2017","unstructured":"Yang Z, Lv Q, Wang Z, Dong X, Yang R, Zhao W (2017) Identification of crucial genes associated with rat traumatic spinal cord injury. Mol Med Rep 15:1997\u20132006. https:\/\/doi.org\/10.3892\/mmr.2017.6267","journal-title":"Mol Med Rep"},{"key":"2289_CR17","doi-asserted-by":"publisher","first-page":"6988","DOI":"10.1002\/jcb.27908","volume":"120","author":"T Wang","year":"2019","unstructured":"Wang T, Wu B, Zhang X, Zhang M, Zhang S, Huang W, Liu T, Yu W et al (2019) Identification of gene coexpression modules, hub genes, and pathways related to spinal cord injury using integrated bioinformatics methods. J Cell Biochem 120:6988\u20136997. https:\/\/doi.org\/10.1002\/jcb.27908","journal-title":"J Cell Biochem"},{"key":"2289_CR18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/BRS.0000000000001323","volume":"41","author":"Y Liu","year":"2016","unstructured":"Liu Y, Han N, Li Q, Li Z (2016) Bioinformatics analysis of microRNA time-course expression in brown rat (rattus norvegicus) spinal cord injury self-repair. Spine (Phila Pa 1976) 41:97\u2013103. https:\/\/doi.org\/10.1097\/BRS.0000000000001323","journal-title":"Spine (Phila Pa 1976)"},{"key":"2289_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12031-020-01549-0","volume":"70","author":"Z Li","year":"2020","unstructured":"Li Z, Yu F, Yu X, Wang S (2020) Potential molecular mechanism and biomarker investigation for spinal cord injury based on bioinformatics analysis. J Mol Neurosci 70:1\u20131353. https:\/\/doi.org\/10.1007\/s12031-020-01549-0","journal-title":"J Mol Neurosci"},{"key":"2289_CR20","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/ana.10472","volume":"53","author":"S Di Giovanni","year":"2003","unstructured":"Di Giovanni S, Knoblach SM, Brandoli C et al (2003) Gene profiling in spinal cord injury shows role of cell cycle neuronal death. Ann Neurol 53:454\u2013468. https:\/\/doi.org\/10.1002\/ana.10472","journal-title":"Ann Neurol"},{"key":"2289_CR21","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1186\/1471-2164-14-583","volume":"14","author":"M Chamankhah","year":"2013","unstructured":"Chamankhah M, Eftekharpour E, Karimi-Abdolrezaee S, Boutros PC, San-Marina S, Fehlings MG (2013) Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. BMC Genomics 14:583. https:\/\/doi.org\/10.1186\/1471-2164-14-583","journal-title":"BMC Genomics"},{"key":"2289_CR22","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1093\/bioinformatics\/bts034","volume":"28","author":"JT Leek","year":"2012","unstructured":"Leek JT, Johnson WE, Parker HS, Jaffe AE, Storey JD (2012) The SVA package for removing batch effects and other unwanted variation in high-throughput experiments. Bioinformatics 28:882\u2013883. https:\/\/doi.org\/10.1093\/bioinformatics\/bts034","journal-title":"Bioinformatics"},{"key":"2289_CR23","doi-asserted-by":"publisher","first-page":"1702","DOI":"10.1007\/s12031-020-01556-1","volume":"70","author":"Y Guo","year":"2020","unstructured":"Guo Y, Huang P, Ning W, Zhang H, Yu C (2020) Identification of core genes and pathways in medulloblastoma by integrated bioinformatics analysis. J Mol Neurosci 70:1702\u20131712. https:\/\/doi.org\/10.1007\/s12031-020-01556-1","journal-title":"J Mol Neurosci"},{"key":"2289_CR24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007","volume":"43","author":"ME Ritchie","year":"2015","unstructured":"Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK (2015) Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 43:e47. https:\/\/doi.org\/10.1093\/nar\/gkv007","journal-title":"Nucleic Acids Res"},{"key":"2289_CR25","doi-asserted-by":"publisher","unstructured":"Harris MA, Clark JI, Ireland A, et al (2006) go The gene ontology (GO) project in 2006. Nucleic Acids Res 34:D322\u2013D326. https:\/\/doi.org\/10.1093\/nar\/gkj021","DOI":"10.1093\/nar\/gkj021"},{"key":"2289_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) ClusterProfiler: an R package for comparing biological themes among gene clusters. Omi A J Integr Biol 16:284\u2013287. https:\/\/doi.org\/10.1089\/omi.2011.0118","journal-title":"Omi A J Integr Biol"},{"key":"2289_CR27","doi-asserted-by":"publisher","first-page":"3316","DOI":"10.3892\/ol.2020.11439","volume":"19","author":"Y Yi","year":"2020","unstructured":"Yi Y, Fang Y, Wu K, Liu Y, Zhang W (2020) Comprehensive gene and pathway analysis of cervical cancer progression. Oncol Lett 19:3316\u20133332. https:\/\/doi.org\/10.3892\/ol.2020.11439","journal-title":"Oncol Lett"},{"key":"2289_CR28","doi-asserted-by":"publisher","first-page":"D590","DOI":"10.1093\/nar\/gky962","volume":"47","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa M, Sato Y, Furumichi M, Morishima K, Tanabe M (2019) New approach for understanding genome variations in KEGG. Nucleic Acids Res 47:D590\u2013D595. https:\/\/doi.org\/10.1093\/nar\/gky962","journal-title":"Nucleic Acids Res"},{"key":"2289_CR29","doi-asserted-by":"publisher","unstructured":"Mathur R, Rotroff D, Ma J, Shojaie A, Motsinger-Reif A (2018) gsea Gene set analysis methods: a systematic comparison. BioData Min 11:1\u201319. https:\/\/doi.org\/10.1186\/s13040-018-0166-8","DOI":"10.1186\/s13040-018-0166-8"},{"key":"2289_CR30","doi-asserted-by":"publisher","first-page":"e155","DOI":"10.1093\/nar\/gkx679","volume":"45","author":"S Peng","year":"2017","unstructured":"Peng S, Yang S, Bo X, Li F (2017) Paragsea: A scalable approach for large-scale gene expression profiling. Nucleic Acids Res 45:e155. https:\/\/doi.org\/10.1093\/nar\/gkx679","journal-title":"Nucleic Acids Res"},{"key":"2289_CR31","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL et al (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102:15545\u201315550. https:\/\/doi.org\/10.1073\/pnas.0506580102","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2289_CR32","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1167\/iovs.61.8.12","volume":"61","author":"N Xu","year":"2020","unstructured":"Xu N, Cui Y, Dong J, Huang L (2020) Exploring the molecular mechanisms of pterygium by constructing lncRNA-miRNA-mRNA regulatory network. Invest Ophthalmol Vis Sci 61:12. https:\/\/doi.org\/10.1167\/iovs.61.8.12","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2289_CR33","doi-asserted-by":"publisher","first-page":"D607","DOI":"10.1093\/nar\/gky1131","volume":"47","author":"D Szklarczyk","year":"2019","unstructured":"Szklarczyk D, Gable AL, Lyon D, Junge A, Wyder S, Huerta-Cepas J, Simonovic M, Doncheva NT et al (2019) STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets. Nucleic Acids Res 47:D607\u2013D613. https:\/\/doi.org\/10.1093\/nar\/gky1131","journal-title":"Nucleic Acids Res"},{"key":"2289_CR34","doi-asserted-by":"publisher","first-page":"145","DOI":"10.15171\/bi.2019.19","volume":"9","author":"MR Asgharzadeh","year":"2019","unstructured":"Asgharzadeh MR, Pourseif MM, Barar J et al (2019) Functional expression and impact of testis-specific gene antigen 10 in breast cancer: a combined in vitro and in silico analysis. BioImpacts 9:145\u2013159. https:\/\/doi.org\/10.15171\/bi.2019.19","journal-title":"BioImpacts"},{"key":"2289_CR35","doi-asserted-by":"publisher","first-page":"2498","DOI":"10.1101\/gr.1239303","volume":"13","author":"P Shannon","year":"2003","unstructured":"Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B et al (2003) Cytoscape: a software environment for integrated models of biomolecular interaction networks. Genome Res 13:2498\u20132504. https:\/\/doi.org\/10.1101\/gr.1239303","journal-title":"Genome Res"},{"key":"2289_CR36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-020-68224-7","volume":"10","author":"J Zhang","year":"2020","unstructured":"Zhang J, Liu X, Zhou W, Cheng G, Wu J, Guo S, Jia S, Liu Y et al (2020) A bioinformatics investigation into molecular mechanism of Yinzhihuang granules for treating hepatitis B by network pharmacology and molecular docking verification. Sci Rep 10:1\u201313. https:\/\/doi.org\/10.1038\/s41598-020-68224-7","journal-title":"Sci Rep"},{"key":"2289_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jsxm.2020.05.008","volume":"17","author":"R Cong","year":"2020","unstructured":"Cong R, Wang Y, Wang Y, Zhang Q, Zhou X, Ji C, Yao L, Song N et al (2020) Comprehensive analysis of lncRNA expression pattern and lncRNA\u2013miRNA\u2013mRNA network in a rat model with cavernous nerve injury erectile dysfunction. J Sex Med 17:1\u201315. https:\/\/doi.org\/10.1016\/j.jsxm.2020.05.008","journal-title":"J Sex Med"},{"key":"2289_CR38","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1752-0509-8-S4-S11","volume":"8","author":"CH Chin","year":"2014","unstructured":"Chin CH, Chen SH, Wu HH, Ho CW, Ko MT, Lin CY (2014) cytoHubba: Identifying hub objects and sub-networks from complex interactome. BMC Syst Biol 8:1\u20137. https:\/\/doi.org\/10.1186\/1752-0509-8-S4-S11","journal-title":"BMC Syst Biol"},{"key":"2289_CR39","doi-asserted-by":"publisher","unstructured":"Zhang Y, Yang X, Zhu XL, Hao JQ, Bai H, Xiao YC, Wang ZZ, Hao CY et al (2020) Bioinformatics analysis of potential core genes for glioblastoma. Biosci Rep 40. https:\/\/doi.org\/10.1042\/BSR20201625","DOI":"10.1042\/BSR20201625"},{"key":"2289_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fonc.2020.00681","volume":"10","author":"CY Li","year":"2020","unstructured":"Li CY, Cai JH, Tsai JJP, Wang CCN (2020) Identification of hub genes associated with development of head and neck squamous cell carcinoma by integrated bioinformatics analysis. Front Oncol 10:1\u201312. https:\/\/doi.org\/10.3389\/fonc.2020.00681","journal-title":"Front Oncol"},{"key":"2289_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-020-01309-5","volume":"20","author":"T Li","year":"2020","unstructured":"Li T, Gu M, Deng A, Qian C (2020) Increased expression of YTHDF1 and HNRNPA2B1 as potent biomarkers for melanoma: a systematic analysis. Cancer Cell Int 20:1\u201314. https:\/\/doi.org\/10.1186\/s12935-020-01309-5","journal-title":"Cancer Cell Int"},{"key":"2289_CR42","doi-asserted-by":"publisher","first-page":"2057","DOI":"10.1007\/s11064-019-02841-1","volume":"44","author":"H Fu","year":"2019","unstructured":"Fu H, Han G, Li H, Liang X, Hu D, Zhang L, Tang P (2019) Identification of key genes and pathways involved in the heterogeneity of intrinsic growth ability between neurons after spinal cord injury in adult zebrafish. Neurochem Res 44:2057\u20132067. https:\/\/doi.org\/10.1007\/s11064-019-02841-1","journal-title":"Neurochem Res"},{"key":"2289_CR43","doi-asserted-by":"publisher","first-page":"2912","DOI":"10.1093\/bioinformatics\/btv300","volume":"31","author":"W Walter","year":"2015","unstructured":"Walter W, S\u00e1nchez-Cabo F, Ricote M (2015) GOplot: an R package for visually combining expression data with functional analysis. Bioinformatics 31:2912\u20132914. https:\/\/doi.org\/10.1093\/bioinformatics\/btv300","journal-title":"Bioinformatics"},{"key":"2289_CR44","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms21238997","volume":"21","author":"GT Kim","year":"2020","unstructured":"Kim GT, Siregar AS, Kim EJ, Lee ES, Nyiramana MM, Woo MS, Hah YS, Han J et al (2020) Upregulation of tresk channels contributes to motor and sensory recovery after spinal cord injury. Int J Mol Sci 21:1\u201315. https:\/\/doi.org\/10.3390\/ijms21238997","journal-title":"Int J Mol Sci"},{"key":"2289_CR45","doi-asserted-by":"publisher","first-page":"e3062","DOI":"10.1002\/jgm.3062","volume":"20","author":"X Han","year":"2018","unstructured":"Han X, Chen Y, Liu Y, Wang Z, Tang G, Tian W (2018) HIF-1\u03b1 promotes bone marrow stromal cell migration to the injury site and enhances functional recovery after spinal cord injury in rats. J Gene Med 20:e3062. https:\/\/doi.org\/10.1002\/jgm.3062","journal-title":"J Gene Med"},{"key":"2289_CR46","doi-asserted-by":"publisher","unstructured":"Luo Z, Wu F, Xue E et al (2019) Hypoxia preconditioning promotes bone marrow mesenchymal stem cells survival by inducing HIF-1\u03b1 in injured neuronal cells derived exosomes culture system. Cell Death Dis 10. https:\/\/doi.org\/10.1038\/s41419-019-1410-y","DOI":"10.1038\/s41419-019-1410-y"},{"key":"2289_CR47","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.neulet.2016.12.033","volume":"652","author":"NJ Batty","year":"2017","unstructured":"Batty NJ, Fenrich KK, Fouad K (2017) The role of cAMP and its downstream targets in neurite growth in the adult nervous system. Neurosci Lett 652:56\u201363. https:\/\/doi.org\/10.1016\/j.neulet.2016.12.033","journal-title":"Neurosci Lett"},{"key":"2289_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2020.602638","volume":"13","author":"J \u00c1vila-Mendoza","year":"2020","unstructured":"\u00c1vila-Mendoza J, Subramani A, Denver RJ (2020) Kr\u00fcppel-like factors 9 and 13 block axon growth by transcriptional repression of key components of the cAMP signaling pathway. Front Mol Neurosci 13:1\u201317. https:\/\/doi.org\/10.3389\/fnmol.2020.602638","journal-title":"Front Mol Neurosci"},{"key":"2289_CR49","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1097\/AJP.0000000000000070","volume":"31","author":"H Li","year":"2015","unstructured":"Li H, Huang Y, Ma C, Yu X, Zhang Z, Shen L (2015) MiR-203 involves in neuropathic pain development and represses rap1a expression in nerve growth factor differentiated neuronal PC12 cells. Clin J Pain 31:36\u201343. https:\/\/doi.org\/10.1097\/AJP.0000000000000070","journal-title":"Clin J Pain"},{"key":"2289_CR50","doi-asserted-by":"publisher","unstructured":"Gao L, Pu X, Huang Y, Huang J (2019) MicroRNA-340-5p relieved chronic constriction injury-induced neuropathic pain by targeting Rap1A in rat model. Genes and Genomics 0:0. https:\/\/doi.org\/10.1007\/s13258-019-00802-0, 41, 713, 721","DOI":"10.1007\/s13258-019-00802-0"},{"key":"2289_CR51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12864-017-3532-x","volume":"18","author":"LL Shi","year":"2017","unstructured":"Shi LL, Zhang N, Xie XM, Chen YJ, Wang R, Shen L, Zhou JS, Hu JG et al (2017) Transcriptome profile of rat genes in injured spinal cord at different stages by RNA-sequencing. BMC Genomics 18:1\u201314. https:\/\/doi.org\/10.1186\/s12864-017-3532-x","journal-title":"BMC Genomics"},{"key":"2289_CR52","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.3892\/etm.2017.4674","volume":"14","author":"Y Xia","year":"2017","unstructured":"Xia Y, Xia H, Chen D, Liao Z, Yan Y (2017) Mechanisms of autophagy and apoptosis mediated by JAK2 signaling pathway after spinal cord injury of rats. Exp Ther Med 14:1589\u20131593. https:\/\/doi.org\/10.3892\/etm.2017.4674","journal-title":"Exp Ther Med"},{"key":"2289_CR53","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1365-2184.2008.00537.x","volume":"41","author":"MK Kang","year":"2008","unstructured":"Kang MK, Kang SK (2008) Interleukin-6 induces proliferation in adult spinal cord-derived neural progenitors via the JAK2\/STAT3 pathway with EGF-induced MAPK phosphorylation. Cell Prolif 41:377\u2013392. https:\/\/doi.org\/10.1111\/j.1365-2184.2008.00537.x","journal-title":"Cell Prolif"},{"key":"2289_CR54","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s12264-019-00368-7","volume":"35","author":"Z Li","year":"2019","unstructured":"Li Z, Chen T, Cao Y, Jiang X, Lin H, Zhang J, Chen Z (2019) Pros and cons: autophagy in acute spinal cord injury. Neurosci Bull 35:941\u2013945. https:\/\/doi.org\/10.1007\/s12264-019-00368-7","journal-title":"Neurosci Bull"},{"key":"2289_CR55","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.gene.2019.04.083","volume":"707","author":"H Li","year":"2019","unstructured":"Li H, Wang Y, Hu X, Ma B, Zhang H (2019) Thymosin beta 4 attenuates oxidative stress-induced injury of spinal cord-derived neural stem\/progenitor cells through the TLR4\/MyD88 pathway. Gene 707:136\u2013142. https:\/\/doi.org\/10.1016\/j.gene.2019.04.083","journal-title":"Gene"},{"key":"2289_CR56","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41419-020-02824-z","volume":"11","author":"S Xu","year":"2020","unstructured":"Xu S, Wang J, Jiang J, Song J, Zhu W, Zhang F, Shao M, Xu H et al (2020) TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K\/AKT pathway after spinal cord injury. Cell Death Dis 11:693. https:\/\/doi.org\/10.1038\/s41419-020-02824-z","journal-title":"Cell Death Dis"},{"key":"2289_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BSR20193315","volume":"40","author":"G Wan","year":"2020","unstructured":"Wan G, An Y, Tao J, Wang Y, Zhou Q, Yang R, Liang Q (2020) MicroRNA-129-5p alleviates spinal cord injury in mice via suppressing the apoptosis and inflammatory response through HMGB1\/TLR4\/NF-\u03baB pathway. Biosci Rep 40:1\u201315. https:\/\/doi.org\/10.1042\/BSR20193315","journal-title":"Biosci Rep"},{"key":"2289_CR58","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.brainresbull.2019.11.008","volume":"155","author":"P Ribeiro","year":"2020","unstructured":"Ribeiro P, Castro MV, Perez M, Cartarozzi LP, Spejo AB, Chiarotto GB, Augusto TM, Oliveira ALR (2020) Toll-like receptor 4 (TLR4) influences the glial reaction in the spinal cord and the neural response to injury following peripheral nerve crush. Brain Res Bull 155:67\u201380. https:\/\/doi.org\/10.1016\/j.brainresbull.2019.11.008","journal-title":"Brain Res Bull"},{"key":"2289_CR59","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1038\/s41420-020-00333-8","volume":"6","author":"T Gaojian","year":"2020","unstructured":"Gaojian T, Dingfei Q, Linwei L, Xiaowei W, Zheng Z, Wei L, Tong Z, Benxiang N et al (2020) Parthenolide promotes the repair of spinal cord injury by modulating M1\/M2 polarization via the NF-\u03baB and STAT 1\/3 signaling pathway. Cell Death Discov 6:97. https:\/\/doi.org\/10.1038\/s41420-020-00333-8","journal-title":"Cell Death Discov"},{"key":"2289_CR60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2020.9277","volume":"20","author":"Z Ji","year":"2020","unstructured":"Ji Z, Jiang X, Li Y, Song J, Chai C, Lu X (2020) Neural stem cells induce M2 polarization of macrophages through the upregulation of interleukin-4. Exp Ther Med 20:1\u20139. https:\/\/doi.org\/10.3892\/etm.2020.9277","journal-title":"Exp Ther Med"},{"key":"2289_CR61","doi-asserted-by":"publisher","first-page":"772","DOI":"10.4103\/1673-5374.295335","volume":"16","author":"T Zhang","year":"2021","unstructured":"Zhang T, Li K, Zhang ZL, Gao K, Lv CL (2021) LncRNA Airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway. Neural Regen Res 16:772\u2013777. https:\/\/doi.org\/10.4103\/1673-5374.295335","journal-title":"Neural Regen Res"},{"key":"2289_CR62","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.26355\/eurrev_201904_17677","volume":"23","author":"B Wang","year":"2019","unstructured":"Wang B, Shen PF, Qu YX et al (2019) MiR-940 promotes spinal cord injury recovery by inhibiting TLR4\/NF-\u03baB pathway-mediated inflammation. Eur Rev Med Pharmacol Sci 23:3190\u20133197. https:\/\/doi.org\/10.26355\/eurrev_201904_17677","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2289_CR63","doi-asserted-by":"publisher","first-page":"14259","DOI":"10.1002\/jcp.28124","volume":"234","author":"Y Su","year":"2019","unstructured":"Su Y, Zong S, Wei C, Song F, Feng H, Qin A, Lian Z, Fu F et al (2019) Salidroside promotes rat spinal cord injury recovery by inhibiting inflammatory cytokine expression and NF-\u03baB and MAPK signaling pathways. J Cell Physiol 234:14259\u201314269. https:\/\/doi.org\/10.1002\/jcp.28124","journal-title":"J Cell Physiol"},{"key":"2289_CR64","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.bbi.2020.01.025","volume":"87","author":"Z Qian","year":"2020","unstructured":"Qian Z, Chang J, Jiang F, Ge D, Yang L, Li Y, Chen H, Cao X (2020) Excess administration of miR-340-5p ameliorates spinal cord injury-induced neuroinflammation and apoptosis by modulating the P38-MAPK signaling pathway. Brain Behav Immun 87:531\u2013542. https:\/\/doi.org\/10.1016\/j.bbi.2020.01.025","journal-title":"Brain Behav Immun"},{"key":"2289_CR65","doi-asserted-by":"publisher","first-page":"2165","DOI":"10.26355\/eurrev_202003_20481","volume":"24","author":"J Ye","year":"2020","unstructured":"Ye J, Xue R, Ji ZY et al (2020) Effect of NT-3 on repair of spinal cord injury through the MAPK signaling pathway. Eur Rev Med Pharmacol Sci 24:2165\u20132172. https:\/\/doi.org\/10.26355\/eurrev_202003_20481","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2289_CR66","doi-asserted-by":"publisher","first-page":"101311","DOI":"10.1016\/j.tice.2019.101311","volume":"62","author":"Y Ni","year":"2020","unstructured":"Ni Y, Gu J, Wu J, Xu L, Rui Y (2020) MGMT-mediated neuron apoptosis in injured rat spinal cord. Tissue Cell 62:101311. https:\/\/doi.org\/10.1016\/j.tice.2019.101311","journal-title":"Tissue Cell"},{"key":"2289_CR67","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.3892\/ijmm.2019.4106","volume":"43","author":"X Yu","year":"2019","unstructured":"Yu X, Zhang S, Zhao D, Zhang X, Xia C, Wang T, Zhang M, Liu T et al (2019) SIRT1 inhibits apoptosis in in vivo and in vitro models of spinal cord injury via microRNA-494. Int J Mol Med 43:1758\u20131768. https:\/\/doi.org\/10.3892\/ijmm.2019.4106","journal-title":"Int J Mol Med"},{"key":"2289_CR68","doi-asserted-by":"publisher","first-page":"2007","DOI":"10.1007\/s11064-019-02838-w","volume":"44","author":"Y Li","year":"2019","unstructured":"Li Y, Guo Y, Fan Y, Tian H, Li K, Mei X (2019) Melatonin enhances autophagy and reduces apoptosis to promote locomotor recovery in spinal cord injury via the PI3K\/AKT\/mTOR signaling pathway. Neurochem Res 44:2007\u20132019. https:\/\/doi.org\/10.1007\/s11064-019-02838-w","journal-title":"Neurochem Res"},{"key":"2289_CR69","doi-asserted-by":"publisher","first-page":"6767","DOI":"10.26355\/eurrev_201908_18714","volume":"23","author":"J Tang","year":"2019","unstructured":"Tang J, Guo WC, Hu JF, Yu L (2019) Let-7 participates in the regulation of inflammatory response in spinal cord injury through PI3K\/Akt signaling pathway. Eur Rev Med Pharmacol Sci 23:6767\u20136773. https:\/\/doi.org\/10.26355\/eurrev_201908_18714","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"2289_CR70","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01981-4","volume":"17","author":"B Ding","year":"2020","unstructured":"Ding B, Lin C, Liu Q, He Y, Ruganzu JB, Jin H, Peng X, Ji S et al (2020) Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE\/NF-\u03baB signaling pathway in vivo and in vitro. J Neuroinflammation 17:1\u201317. https:\/\/doi.org\/10.1186\/s12974-020-01981-4","journal-title":"J Neuroinflammation"},{"key":"2289_CR71","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2020.00217","volume":"12","author":"Y Kong","year":"2020","unstructured":"Kong Y, Wang F, Wang J, Liu C, Zhou Y, Xu Z, Zhang C, Sun B et al (2020) Pathological mechanisms linking diabetes mellitus and Alzheimer\u2019s disease: the receptor for advanced glycation end products (RAGE). Front Aging Neurosci 12:1\u201310. https:\/\/doi.org\/10.3389\/fnagi.2020.00217","journal-title":"Front Aging Neurosci"},{"key":"2289_CR72","doi-asserted-by":"publisher","first-page":"105069","DOI":"10.1016\/j.phrs.2020.105069","volume":"160","author":"F Abbaszadeh","year":"2020","unstructured":"Abbaszadeh F, Fakhri S, Khan H (2020) Targeting apoptosis and autophagy following spinal cord injury: therapeutic approaches to polyphenols and candidate phytochemicals. Pharmacol Res 160:105069. https:\/\/doi.org\/10.1016\/j.phrs.2020.105069","journal-title":"Pharmacol Res"},{"key":"2289_CR73","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0230080","volume":"15","author":"K Yagura","year":"2020","unstructured":"Yagura K, Ohtaki H, Tsumuraya T, Sato A, Miyamoto K, Kawada N, Suzuki K, Nakamura M et al (2020) The enhancement of CCL2 and CCL5 by human bone marrow-derived mesenchymal stem\/stromal cells might contribute to inflammatory suppression and axonal extension after spinal cord injury. PLoS One 15:1\u201323. https:\/\/doi.org\/10.1371\/journal.pone.0230080","journal-title":"PLoS One"},{"key":"2289_CR74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.cbi.2016.06.009","volume":"256","author":"DT Longhi-Balbinot","year":"2016","unstructured":"Longhi-Balbinot DT, Rossaneis AC, Pinho-Ribeiro FA, Bertozzi MM, Cunha FQ, Alves-Filho JC, Cunha TM, Peron JPS et al (2016) The nitroxyl donor, Angeli\u2019s salt, reduces chronic constriction injury-induced neuropathic pain. Chem Biol Interact 256:1\u20138. https:\/\/doi.org\/10.1016\/j.cbi.2016.06.009","journal-title":"Chem Biol Interact"},{"key":"2289_CR75","doi-asserted-by":"publisher","unstructured":"Hyochol Ahn, et al 2017 (2017) HHS Public Access Author manuscript Trends Immunol. Author manuscript; available in PMC 2018 May 01. Published in final edited form as: Trends Immunol. 2017 May ; 38(5): 310\u2013322. doi:https:\/\/doi.org\/10.1016\/j.it.2017.01.006. IL-17 signaling: the yin and the yang Nilesh H. Physiol Behav 176:139\u2013148. https:\/\/doi.org\/10.1016\/j.it.2017.01.006.IL-17","DOI":"10.1016\/j.it.2017.01.006 10.1016\/j.it.2017.01.006.IL-17"},{"key":"2289_CR76","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1097\/nen.0b013e3181567d59","volume":"66","author":"NK Liu","year":"2007","unstructured":"Liu NK, Zhang YP, Han S, Pei J, Xu LY, Lu PH, Shields CB, Xu XM (2007) Annexin A1 reduces inflammatory reaction and tissue damage through inhibition of phospholipase A2 activation in adult rats following spinal cord injury. J Neuropathol Exp Neurol 66:932\u2013943. https:\/\/doi.org\/10.1097\/nen.0b013e3181567d59","journal-title":"J Neuropathol Exp Neurol"},{"key":"2289_CR77","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1172\/jci.insight.98254","volume":"4","author":"FH Brennan","year":"2019","unstructured":"Brennan FH, Jogia T, Gillespie ER, Blomster LV, Li XX, Nowlan B, Williams GM, Jacobson E et al (2019) Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2. JCI Insight 4:1\u201318. https:\/\/doi.org\/10.1172\/jci.insight.98254","journal-title":"JCI Insight"},{"key":"2289_CR78","doi-asserted-by":"publisher","unstructured":"Li L, Xiong Z yong, Qian ZM, et al (2014) Complement C5a is detrimental to histological and functional locomotor recovery after spinal cord injury in mice. Neurobiol Dis 66:74\u201382. https:\/\/doi.org\/10.1016\/j.nbd.2014.02.008","DOI":"10.1016\/j.nbd.2014.02.008"},{"key":"2289_CR79","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/sc.1996.71","volume":"34","author":"Y Hiraizumi","year":"1996","unstructured":"Hiraizumi Y, Fujimaki E, Transfeldt EE, Kawahara N, Fiegel VD, Knighton D, Sung JH (1996) The effect of the platelet derived wound healing formula and the nerve growth factor on the experimentally injured spinal cord. Spinal Cord 34:394\u2013402. https:\/\/doi.org\/10.1038\/sc.1996.71","journal-title":"Spinal Cord"},{"key":"2289_CR80","doi-asserted-by":"publisher","first-page":"2075","DOI":"10.1089\/neu.2016.4701","volume":"34","author":"PJC Biggins","year":"2017","unstructured":"Biggins PJC, Brennan FH, Taylor SM, Woodruff TM, Ruitenberg MJ (2017) The alternative receptor for complement component 5a, C5aR2, conveys neuroprotection in traumatic spinal cord injury. J Neurotrauma 34:2075\u20132085. https:\/\/doi.org\/10.1089\/neu.2016.4701","journal-title":"J Neurotrauma"},{"key":"2289_CR81","doi-asserted-by":"publisher","first-page":"3707","DOI":"10.1182\/blood-2019-130627","volume":"134","author":"A Elujoba-Bridenstine","year":"2019","unstructured":"Elujoba-Bridenstine A, Shao L, Zink K, Sanchez L, Cox B, Pajcini K, Tamplin OJ (2019) The neurotransmitter receptor Gabbr1 regulates proliferation and function of hematopoietic stem and progenitor cells. Blood 134:3707\u20133707. https:\/\/doi.org\/10.1182\/blood-2019-130627","journal-title":"Blood"},{"key":"2289_CR82","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1016\/j.bbi.2009.11.007","volume":"24","author":"I Pineau","year":"2010","unstructured":"Pineau I, Sun L, Bastien D, Lacroix S (2010) Astrocytes initiate inflammation in the injured mouse spinal cord by promoting the entry of neutrophils and inflammatory monocytes in an IL-1 receptor\/MyD88-dependent fashion. Brain Behav Immun 24:540\u2013553. https:\/\/doi.org\/10.1016\/j.bbi.2009.11.007","journal-title":"Brain Behav Immun"},{"key":"2289_CR83","doi-asserted-by":"publisher","first-page":"11731","DOI":"10.1523\/JNEUROSCI.1395-17.2017","volume":"37","author":"I Francos-Quijorna","year":"2017","unstructured":"Francos-Quijorna I, Santos-Nogueira E, Gronert K, Sullivan AB, Kopp MA, Brommer B, David S, Schwab JM et al (2017) Maresin 1 promotes inflammatory resolution, neuroprotection, and functional neurological recovery after spinal cord injury. J Neurosci 37:11731\u201311743. https:\/\/doi.org\/10.1523\/JNEUROSCI.1395-17.2017","journal-title":"J Neurosci"},{"key":"2289_CR84","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1111\/bph.12588","volume":"171","author":"SD Boomkamp","year":"2014","unstructured":"Boomkamp SD, McGrath MA, Houslay MD, Barnett SC (2014) Epac and the high affinity rolipram binding conformer of PDE4 modulate neurite outgrowth and myelination using an in vitro spinal cord injury model. Br J Pharmacol 171:2385\u20132398. https:\/\/doi.org\/10.1111\/bph.12588","journal-title":"Br J Pharmacol"},{"key":"2289_CR85","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1002\/stem.2006","volume":"33","author":"S Watanabe","year":"2015","unstructured":"Watanabe S, Uchida K, Nakajima H, Matsuo H, Sugita D, Yoshida A, Honjoh K, Johnson WEB et al (2015) Early transplantation of mesenchymal stem cells after spinal cord injury relieves pain hypersensitivity through suppression of pain-related signaling cascades and reduced inflammatory cell recruitment. Stem Cells 33:1902\u20131914. https:\/\/doi.org\/10.1002\/stem.2006","journal-title":"Stem Cells"},{"key":"2289_CR86","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.3892\/ijmm.2020.4509","volume":"45","author":"G Chen","year":"2020","unstructured":"Chen G, Zhou Z, Sha W, Wang L, Yan F, Yang X, Qin X, Wu M et al (2020) A novel CX3CR1 inhibitor AZD8797 facilitates early recovery of rat acute spinal cord injury by inhibiting inflammation and apoptosis. Int J Mol Med 45:1373\u20131384. https:\/\/doi.org\/10.3892\/ijmm.2020.4509","journal-title":"Int J Mol Med"},{"key":"2289_CR87","doi-asserted-by":"publisher","first-page":"2167","DOI":"10.1007\/s12035-016-9787-4","volume":"54","author":"\u0141A Poniatowski","year":"2017","unstructured":"Poniatowski \u0141A, Wojdasiewicz P, Krawczyk M, Szukiewicz D, Gasik R, Kubaszewski \u0141, Kurkowska-Jastrz\u0119bska I (2017) Analysis of the role of CX3CL1 (fractalkine) and its receptor CX3CR1 in traumatic brain and spinal cord injury: Insight into recent advances in actions of neurochemokine agents. Mol Neurobiol 54:2167\u20132188. https:\/\/doi.org\/10.1007\/s12035-016-9787-4","journal-title":"Mol Neurobiol"},{"key":"2289_CR88","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.neulet.2017.03.009","volume":"646","author":"JF Sun","year":"2017","unstructured":"Sun JF, Yang HL, Huang YH, Chen Q, Cao XB, Li DP, Shu HM, Jiang RY (2017) CaSR and calpain contribute to the ischemia reperfusion injury of spinal cord. Neurosci Lett 646:49\u201355. https:\/\/doi.org\/10.1016\/j.neulet.2017.03.009","journal-title":"Neurosci Lett"},{"key":"2289_CR89","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1016\/j.jpain.2020.01.001","volume":"21","author":"MR Sapio","year":"2020","unstructured":"Sapio MR, Iadarola MJ, Loydpierson AJ, Kim JJ, Thierry-Mieg D, Thierry-Mieg J, Maric D, Mannes AJ (2020) Dynorphin and enkephalin opioid peptides and transcripts in spinal cord and dorsal root ganglion during peripheral inflammatory hyperalgesia and allodynia. J Pain 21:988\u20131004. https:\/\/doi.org\/10.1016\/j.jpain.2020.01.001","journal-title":"J Pain"},{"key":"2289_CR90","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.neuroscience.2018.08.013","volume":"390","author":"E Rojewska","year":"2018","unstructured":"Rojewska E, Wawrzczak-Bargiela A, Szucs E, Benyhe S, Starnowska J, Mika J, Przewlocki R, Przewlocka B (2018) Alterations in the activity of spinal and thalamic opioid systems in a mice neuropathic pain model. Neuroscience 390:293\u2013302. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.08.013","journal-title":"Neuroscience"},{"key":"2289_CR91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13059-016-1061-6","volume":"17","author":"HE Shamseldin","year":"2016","unstructured":"Shamseldin HE, Masuho I, Alenizi A, Alyamani S, Patil DN, Ibrahim N, Martemyanov KA, Alkuraya FS (2016) GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. Genome Biol 17:1\u20139. https:\/\/doi.org\/10.1186\/s13059-016-1061-6","journal-title":"Genome Biol"},{"key":"2289_CR92","doi-asserted-by":"publisher","unstructured":"Ju LH, Choi TI, Kim YM et al (2020) Regulation of habenular G-protein gamma 8 on learning and memory via modulation of the central acetylcholine system. Mol Psychiatry. https:\/\/doi.org\/10.1038\/s41380-020-00893-2","DOI":"10.1038\/s41380-020-00893-2"},{"key":"2289_CR93","doi-asserted-by":"publisher","first-page":"115","DOI":"10.22203\/eCM.v040a07","volume":"40","author":"Z Li","year":"2020","unstructured":"Li Z, Wystrach L, Bernstein A et al (2020) The tissue-renin-angiotensin system of the human intervertebral disc. Eur Cells Mater 40:115\u2013132. https:\/\/doi.org\/10.22203\/eCM.v040a07","journal-title":"Eur Cells Mater"},{"key":"2289_CR94","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1053\/j.gastro.2019.02.040","volume":"156","author":"ZW Li","year":"2019","unstructured":"Li ZW, Sun B, Gong T, Guo S, Zhang J, Wang J, Sugawara A, Jiang M et al (2019) GNAI1 and GNAI3 reduce colitis-associated tumorigenesis in mice by blocking IL6 signaling and down-regulating expression of GNAI2. Gastroenterology 156:2297\u20132312. https:\/\/doi.org\/10.1053\/j.gastro.2019.02.040","journal-title":"Gastroenterology"},{"key":"2289_CR95","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-019-0862-8","volume":"7","author":"A Mendsaikhan","year":"2019","unstructured":"Mendsaikhan A, Tooyama I, Bellier JP, Serrano GE, Sue LI, Lue LF, Beach TG, Walker DG (2019) Characterization of lysosomal proteins Progranulin and Prosaposin and their interactions in Alzheimer\u2019s disease and aged brains: increased levels correlate with neuropathology. Acta Neuropathol Commun 7:1\u201326. https:\/\/doi.org\/10.1186\/s40478-019-0862-8","journal-title":"Acta Neuropathol Commun"},{"key":"2289_CR96","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1385\/CRIAI:28:3:197","volume":"28","author":"M Nakamura","year":"2005","unstructured":"Nakamura M, Okada S, Toyama Y, Okano H (2005) Role of IL-6 in spinal cord injury in a mouse model. Clin Rev Allergy Immunol 28:197\u2013203. https:\/\/doi.org\/10.1385\/CRIAI:28:3:197","journal-title":"Clin Rev Allergy Immunol"},{"key":"2289_CR97","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnmol.2015.00035","volume":"8","author":"A Alizadeh","year":"2015","unstructured":"Alizadeh A, Dyck SM, Karimi-Abdolrezaee S (2015) Myelin damage and repair in pathologic CNS: challenges and prospects. Front Mol Neurosci 8:1\u201327. https:\/\/doi.org\/10.3389\/fnmol.2015.00035","journal-title":"Front Mol Neurosci"},{"key":"2289_CR98","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/cells9041029","volume":"9","author":"PM Bendix","year":"2020","unstructured":"Bendix PM, Simonsen AC, Florentsen CD, H\u00e4ger SC, Mularski A, Zanjani AAH, Moreno-Pescador G, Klenow MB et al (2020) Interdisciplinary synergy to reveal mechanisms of annexin-mediated plasma membrane shaping and repair. Cells 9:1\u201312. https:\/\/doi.org\/10.3390\/cells9041029","journal-title":"Cells"},{"key":"2289_CR99","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1172\/JCI124635","volume":"130","author":"S McArthur","year":"2020","unstructured":"McArthur S, Juban G, Gobbetti T, Desgeorges T, Theret M, Gondin J, Toller-Kawahisa JE, Reutelingsperger CP et al (2020) Annexin A1 drives macrophage skewing to accelerate muscle regeneration through AMPK activation. J Clin Invest 130:1156\u20131167. https:\/\/doi.org\/10.1172\/JCI124635","journal-title":"J Clin Invest"},{"key":"2289_CR100","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.npep.2016.10.007","volume":"61","author":"J Chen","year":"2017","unstructured":"Chen J, Cui Z, Yang S, Wu C, Li W, Bao G, Xu G, Sun Y et al (2017) The upregulation of annexin A2 after spinal cord injury in rats may have implication for astrocyte proliferation. Neuropeptides 61:67\u201376. https:\/\/doi.org\/10.1016\/j.npep.2016.10.007","journal-title":"Neuropeptides"},{"key":"2289_CR101","doi-asserted-by":"publisher","first-page":"969","DOI":"10.4103\/1673-5374.208592","volume":"12","author":"ZQ Zhong","year":"2017","unstructured":"Zhong ZQ, Xiang Y, Hu X et al (2017) Synaptosomal-associated protein 25 may be an intervention target for improving sensory and locomotor functions after spinal cord contusion. Neural Regen Res 12:969\u2013976. https:\/\/doi.org\/10.4103\/1673-5374.208592","journal-title":"Neural Regen Res"},{"key":"2289_CR102","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12868-017-0348-1","volume":"18","author":"X Liu","year":"2017","unstructured":"Liu X, Sun Y, Li H, Li Y, Li M, Yuan Y, Cui S, Yao D (2017) Effect of Spp1 on nerve degeneration and regeneration after rat sciatic nerve injury. BMC Neurosci 18:1\u201310. https:\/\/doi.org\/10.1186\/s12868-017-0348-1","journal-title":"BMC Neurosci"},{"key":"2289_CR103","doi-asserted-by":"publisher","first-page":"817-833.e4","DOI":"10.1016\/j.neuron.2017.07.037","volume":"95","author":"Y Liu","year":"2017","unstructured":"Liu Y, Wang X, Li W et al (2017) A sensitized IGF1 treatment restores corticospinal axon-dependent functions. Neuron 95:817-833.e4. https:\/\/doi.org\/10.1016\/j.neuron.2017.07.037","journal-title":"Neuron"},{"key":"2289_CR104","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s00401-003-0775-1","volume":"107","author":"Y Fu","year":"2004","unstructured":"Fu Y, Hashimoto M, Ino H, Murakami M, Yamazaki M, Moriya H (2004) Spinal root avulsion-induced upregulation of osteopontin expression in the adult rat spinal cord. Acta Neuropathol 107:8\u201316. https:\/\/doi.org\/10.1007\/s00401-003-0775-1","journal-title":"Acta Neuropathol"},{"key":"2289_CR105","doi-asserted-by":"publisher","first-page":"3603","DOI":"10.1523\/JNEUROSCI.4805-06.2007","volume":"27","author":"M Hashimoto","year":"2007","unstructured":"Hashimoto M, Sun D, Rittling SR, Denhardt DT, Young W (2007) Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls. J Neurosci 27:3603\u20133611. https:\/\/doi.org\/10.1523\/JNEUROSCI.4805-06.2007","journal-title":"J Neurosci"},{"key":"2289_CR106","doi-asserted-by":"publisher","first-page":"134935","DOI":"10.1016\/j.neulet.2020.134935","volume":"729","author":"J Kyyri\u00e4inen","year":"2020","unstructured":"Kyyri\u00e4inen J, Tapiala J, Lipponen A, Ekolle Ndode-Ekane X, Pitk\u00e4nen A (2020) Plau\/Plaur double-deficiency did not worsen lesion severity or vascular integrity after traumatic brain injury. Neurosci Lett 729:134935. https:\/\/doi.org\/10.1016\/j.neulet.2020.134935","journal-title":"Neurosci Lett"},{"key":"2289_CR107","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1117\/12.2549369.Hyperspectral","volume":"176","author":"Freeman","year":"2018","unstructured":"Freeman (2018) Endothelial cell-specific deletion of P2Y2 receptor promotes plaque stability in atherosclerosis-susceptible ApoE-null mice. Physiol Behav 176:139\u2013148. https:\/\/doi.org\/10.1117\/12.2549369.Hyperspectral","journal-title":"Physiol Behav"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02289-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02289-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02289-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T16:28:10Z","timestamp":1621268890000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02289-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,23]]},"references-count":107,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2289"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02289-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,23]]},"assertion":[{"value":"24 September 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}