{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T21:18:10Z","timestamp":1775251090612,"version":"3.50.1"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Natural Scientific Foundation of China","award":["81322020, 81230032, and 81171313"],"award-info":[{"award-number":["81322020, 81230032, and 81171313"]}]},{"name":"Natural Scientific Foundation of China","award":["81801686"],"award-info":[{"award-number":["81801686"]}]},{"name":"Natural Scientific Foundation of China","award":["81601486"],"award-info":[{"award-number":["81601486"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1007\/s12035-021-02292-2","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T07:02:36Z","timestamp":1611644556000},"page":"2757-2769","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Different posterior hippocampus and default mode network modulation in young APOE \u03b54 carriers: a functional connectome-informed phenotype longitudinal study"],"prefix":"10.1007","volume":"58","author":[{"given":"Li Juan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U. Joseph","family":"Schoepf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akos","family":"Varga-Szemes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rock H.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yun Fei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gui Fen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang Ming","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6664-7224","authenticated-orcid":false,"given":"Long Jiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"2292_CR1","doi-asserted-by":"crossref","unstructured":"Kim DH, Yeo SH, Park J-M,\u00a0Choi JY, Lee TH, Park SY, Ock MS, Eo J et al (2014) Genetic markers for diagnosis and pathogenesis of Alzheimer\u2019s disease. Gene 545:185\u2013193","DOI":"10.1016\/j.gene.2014.05.031"},{"key":"2292_CR2","doi-asserted-by":"crossref","unstructured":"Lu T, Aron L, Zullo J, Pan Y, Kim H, Chen Y, Yang TH, Kim HM et al (2014) REST and stress resistance in ageing and Alzheimer\u2019s disease. Nature 507:448\u2013454","DOI":"10.1038\/nature13163"},{"key":"2292_CR3","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1007\/s11682-016-9623-5","volume":"11","author":"Q Ye","year":"2017","unstructured":"Ye Q, Su F, Shu H, Gong L, Xie C, Zhang Z, Bai F (2017) The apolipoprotein E gene affects the three-year trajectories of compensatory neural processes in the left-lateralized hippocampal network. Brain Imaging Behav 11:1446\u20131458","journal-title":"Brain Imaging Behav"},{"key":"2292_CR4","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.nicl.2016.12.002","volume":"13","author":"TT Tran","year":"2017","unstructured":"Tran TT, Speck CL, Pisupati A, Gallagher M, Bakker A (2017) Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. NeuroImage: Clin 13:237\u2013245","journal-title":"NeuroImage: Clin"},{"key":"2292_CR5","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.neuroimage.2014.04.081","volume":"98","author":"V Heise","year":"2014","unstructured":"Heise V, Filippini N, Trachtenberg AJ, Suri S, Ebmeier KP, Mackay CE (2014) Apolipoprotein E genotype, gender and age modulate connectivity of the hippocampus in healthy adults. NeuroImage 98:23\u201330","journal-title":"NeuroImage"},{"key":"2292_CR6","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.trsl.2016.03.005","volume":"175","author":"D Dustin","year":"2016","unstructured":"Dustin D, Hall BM, Annapragada A, Pautler RG (2016) Neuroimaging in Alzheimer\u2019s disease: preclinical challenges toward clinical efficacy. Transl Res 175:37\u201353","journal-title":"Transl Res"},{"key":"2292_CR7","doi-asserted-by":"crossref","unstructured":"Zheng LJ, Su YY, Wang YF,\u00a0Schoepf UJ, Varga-Szemes A, Pannell J, Liang X, Zheng G et al (2018) Different hippocampus functional connectivity patterns in healthy young adults with mutations of APP\/Presenilin-1\/2 and APOE\u03b54. Mol Neurobiol 55:3439\u20133450","DOI":"10.1007\/s12035-017-0540-4"},{"key":"2292_CR8","doi-asserted-by":"crossref","unstructured":"Khan W, Westman E, Jones N, Wahlund LO, Mecocci P, Vellas B, Tsolaki M, K\u0142oszewska I et al (2015) Automated hippocampal subfield measures as predictors of conversion from mild cognitive impairment to Alzheimer\u2019s disease in two independent cohorts. Brain Topogr 28:746\u2013759","DOI":"10.1007\/s10548-014-0415-1"},{"key":"2292_CR9","doi-asserted-by":"crossref","unstructured":"Zheng F, Cui D, Zhang L,\u00a0Zhang S, Zhao Y, Liu X, Liu C, Li Z et al (2018) The volume of hippocampal subfields in relation to decline of memory recall across the adult lifespan. Front Aging Neurosci 10:320","DOI":"10.3389\/fnagi.2018.00320"},{"key":"2292_CR10","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1002\/hipo.22820","volume":"28","author":"MK Chawla","year":"2018","unstructured":"Chawla MK, Sutherland VL, Olson K, McNaughton BL, Barnes CA (2018) Behavior-driven arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3, and dentate gyrus in rat dorsal hippocampus. Hippocampus 28:178\u2013185","journal-title":"Hippocampus"},{"key":"2292_CR11","doi-asserted-by":"crossref","unstructured":"Mufson EJ, Mahady L, Waters D,\u00a0Counts SE, Perez SE, DeKosky ST, Ginsberg SD, Ikonomovic MD et al\u00a0(2015) Hippocampal plasticity during the progression of Alzheimer\u2019s disease. Neuroscience 309:51\u201367","DOI":"10.1016\/j.neuroscience.2015.03.006"},{"key":"2292_CR12","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/hipo.22807","volume":"28","author":"J Persson","year":"2018","unstructured":"Persson J, Stening E, Nordin K, S\u00f6derlund H (2018) Predicting episodic and spatial memory performance from hippocampal resting-state functional connectivity: evidence for an anterior-posterior division of function. Hippocampus 28:53\u201366","journal-title":"Hippocampus"},{"key":"2292_CR13","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1016\/j.cortex.2019.04.015","volume":"119","author":"I Prze\u017adzik","year":"2019","unstructured":"Prze\u017adzik I, Faber M, Fern\u00e1ndez G, Beckmann CF, Haak KV (2019) The functional organisation of the hippocampus along its long axis is gradual and predicts recollection. Cortex 119:324\u2013335","journal-title":"Cortex"},{"key":"2292_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","volume":"65","author":"MS Fanselow","year":"2010","unstructured":"Fanselow MS, Dong H-WW (2010) Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65:7\u201319","journal-title":"Neuron"},{"issue":"1","key":"2292_CR15","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41467-017-02752-1","volume":"9","author":"HR Dimsdale-Zucker","year":"2018","unstructured":"Dimsdale-Zucker HR, Ritchey M, Ekstrom AD, Yonelinas AP, Ranganath C (2018) CA1 and CA3 differentially support spontaneous retrieval of episodic contexts within human hippocampal subfields. Nat Commun 9(1):294","journal-title":"Nat Commun"},{"key":"2292_CR16","doi-asserted-by":"crossref","unstructured":"Harrison TM, Mahmood Z, Lau EP et al (2016) An Alzheimers disease genetic risk score predicts longitudinal thinning of hippocampal complex subregions in healthy older adults. eNeuro 3(3):ENEURO.0098-16.2016","DOI":"10.1523\/ENEURO.0098-16.2016"},{"key":"2292_CR17","doi-asserted-by":"publisher","first-page":"20873","DOI":"10.1038\/srep20873","volume":"6","author":"X Li","year":"2016","unstructured":"Li X, Li D, Li Q, Li Y, Li K, Li S, Han Y (2016) Hippocampal subfield volumetry in patients with subcortical vascular mild cognitive impairment. Sci Rep 6:20873","journal-title":"Sci Rep"},{"key":"2292_CR18","doi-asserted-by":"crossref","unstructured":"de Flores R, Mutlu J, Bejanin A,\u00a0Gonneaud J, Landeau B, Tomadesso C, M\u00e9zenge F, de la Sayette V et al (2017) Intrinsic connectivity of hippocampal subfields in normal elderly and mild cognitive impairment patients. Hum Brain Mapp 38:4922\u20134932","DOI":"10.1002\/hbm.23704"},{"key":"2292_CR19","doi-asserted-by":"publisher","first-page":"3020","DOI":"10.1002\/hbm.22825","volume":"36","author":"AN Voineskos","year":"2015","unstructured":"Voineskos AN, Winterburn JL, Felsky D, Pipitone J, Rajji TK, Mulsant BH, Chakravarty MM (2015) Hippocampal (subfield) volume and shape in relation to cognitive performance across the adult lifespan. Hum Brain Mapp 36:3020\u20133037","journal-title":"Hum Brain Mapp"},{"key":"2292_CR20","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1080\/17588928.2014.975680","volume":"5","author":"S Blum","year":"2014","unstructured":"Blum S, Habeck C, Steffener J, Razlighi Q, Stern Y (2014) Functional connectivity of the posterior hippocampus is more dominant as we age. Cogn Neurosci 5:150\u2013159","journal-title":"Cogn Neurosci"},{"key":"2292_CR21","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1002\/hipo.22517","volume":"26","author":"AM Daugherty","year":"2016","unstructured":"Daugherty AM, Bender AR, Raz N, Ofen N (2016) Age differences in hippocampal subfield volumes from childhood to late adulthood. Hippocampus 26:220\u2013228","journal-title":"Hippocampus"},{"key":"2292_CR22","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuroimage.2017.03.047","volume":"153","author":"AM Daugherty","year":"2017","unstructured":"Daugherty AM, Flinn R, Ofen N (2017) Hippocampal CA3-dentate gyrus volume uniquely linked to improvement in associative memory from childhood to adulthood. NeuroImage 153:75\u201385","journal-title":"NeuroImage"},{"key":"2292_CR23","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/hipo.20614","volume":"19","author":"SG Mueller","year":"2009","unstructured":"Mueller SG, Weiner MW (2009) Selective effect of age, Apo e4, and Alzheimer\u2019s disease on hippocampal subfields. Hippocampus 19:558\u2013564","journal-title":"Hippocampus"},{"key":"2292_CR24","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1212\/WNL.0000000000000154","volume":"82","author":"GA Kerchner","year":"2014","unstructured":"Kerchner GA, Berdnik D, Shen JC, Bernstein JD, Fenesy MC, Deutsch GK, Wyss-Coray T, Rutt BK (2014) APOE e4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory. Neurology 82:691\u2013697","journal-title":"Neurology"},{"key":"2292_CR25","doi-asserted-by":"crossref","unstructured":"Habes M, Janowitz D, Erus G,\u00a0Toledo JB, Resnick SM, Doshi J, van der Auwera S,Wittfeld K et al (2016) Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns. Transl Psychiatry 6(4):e775","DOI":"10.1038\/tp.2016.39"},{"key":"2292_CR26","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1002\/hbm.23036","volume":"37","author":"TM Harrison","year":"2016","unstructured":"Harrison TM, Burggren AC, Small GW, Bookheimer SY (2016) Altered memory-related functional connectivity of the anterior and posterior hippocampus in older adults at increased genetic risk for Alzheimer\u2019s disease. Hum Brain Mapp 37:366\u2013380","journal-title":"Hum Brain Mapp"},{"key":"2292_CR27","doi-asserted-by":"crossref","unstructured":"Filippini N, MacIntosh BJ, Hough MG, Goodwin GM, Frisoni GB, Smith SM, Matthews PM, Beckmann CF et al (2009) Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele.\u00a0Proc Natl Acad Sci U S A 106:7209\u20137214","DOI":"10.1073\/pnas.0811879106"},{"key":"2292_CR28","doi-asserted-by":"crossref","unstructured":"Nichols LM, Masdeu JC, Mattay VS,\u00a0Kohn P, Emery M, Sambataro F, Kolachana B, Elvev\u00e5g B et al\u00a0(2012) Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults. Arch Gen Psychiatry 69:804\u2013813","DOI":"10.1001\/archgenpsychiatry.2011.1893"},{"key":"2292_CR29","doi-asserted-by":"crossref","unstructured":"Filippini N, Ebmeier KP, MacIntosh BJ, Trachtenberg AJ, Frisoni GB, Wilcock GK, Beckmann CF, Smith SM et al\u00a0(2011) Differential effects of the APOE genotype on brain function across the lifespan. NeuroImage 54:602\u2013610","DOI":"10.1016\/j.neuroimage.2010.08.009"},{"key":"2292_CR30","doi-asserted-by":"crossref","unstructured":"Liao W, Fan YS, Yang S, Li J, Duan X, Cui Q, Chen H (2019) Preservation effect: cigarette smoking acts on the dynamic of influences among unifying neuropsychiatric triple networks in Schizophrenia. Schizophr Bull 45(6):1242\u20131250","DOI":"10.1093\/schbul\/sby184"},{"key":"2292_CR31","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1017\/S1041610218001370","volume":"31","author":"TCC Pinto","year":"2019","unstructured":"Pinto TCC, Machado L, Bulgacov TM, Rodrigues-J\u00fanior AL, Costa MLG, Ximenes RCC, Sougey EB (2019) Is the Montreal Cognitive Assessment (MoCA) screening superior to the Mini-Mental State Examination (MMSE) in the detection of mild cognitive impairment (MCI) and Alzheimer\u2019s Disease (AD) in the elderly? Int Psychogeriatr 31:491\u2013504","journal-title":"Int Psychogeriatr"},{"key":"2292_CR32","doi-asserted-by":"crossref","unstructured":"Lehmann M, Ghosh PM, Madison C, Karydas A, Coppola G, O\u2019Neil JP, Huang Y, Miller BL et al\u00a0(2013) Greater medial temporal hypometabolism and lower cortical amyloid burden in ApoE4-positive AD patients. J Neurol Neurosurg Psychiatry 85:266\u2013273","DOI":"10.1136\/jnnp-2013-305858"},{"key":"2292_CR33","doi-asserted-by":"publisher","first-page":"10256","DOI":"10.1073\/pnas.1001412107","volume":"107","author":"DA Wolk","year":"2010","unstructured":"Wolk DA, Dickerson BC (2010) Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 107:10256\u201310261","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2292_CR34","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3233\/JAD-142451","volume":"45","author":"TAK Susanto","year":"2015","unstructured":"Susanto TAK, Pua EPK, Zhou J, Alzheimer\u2019s disease neuroimaging I (2015) cognition, brain atrophy, and cerebrospinal fluid biomarkers changes from preclinical to dementia stage of alzheimer\u2019s disease and the influence of apolipoprotein E. J Alzheimers Dis 45:253\u2013268","journal-title":"J Alzheimers Dis"},{"key":"2292_CR35","doi-asserted-by":"crossref","unstructured":"Cacciaglia R, Molinuevo JL, Falc\u00f3n C,\u00a0Brugulat-Serrat A, S\u00e1nchez-Benavides G, Gramunt N, Esteller M, Mor\u00e1n S et al\u00a0(2018) Effects of APOE-\u03b54 allele load on brain morphology in a cohort of middle-aged healthy individuals with enriched genetic risk for Alzheimer\u2019s disease. Alzheimers Dement 14(7):902\u2013912","DOI":"10.1016\/j.jalz.2018.01.016"},{"key":"2292_CR36","unstructured":"Yan C, Cheung B, Colcombe S et al (2012) The motion crisis in functional connectomics: damage assessment and control for resting-state fMRI. F1000Posters 2012 3:1270 (poster)"},{"key":"2292_CR37","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/brain.2012.0080","volume":"2","author":"ZS Saad","year":"2012","unstructured":"Saad ZS, Gotts SJ, Murphy K, Chen G, Jo HJ, Martin A, Cox RW (2012) Trouble at rest: how correlation patterns and group differences become distorted after global signal regression. Brain Connect 2:25\u201332","journal-title":"Brain Connect"},{"key":"2292_CR38","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1016\/S1053-8119(03)00169-1","volume":"19","author":"JA Maldjian","year":"2003","unstructured":"Maldjian JA, Laurienti PJ, Kraft RA, Burdette JH (2003) An automated method for neuroanatomic and cytoarchitectonic atlas-based interrogation of fMRI data sets. NeuroImage 19:1233\u20131239","journal-title":"NeuroImage"},{"key":"2292_CR39","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1038\/npp.2013.122","volume":"38","author":"AC Chen","year":"2013","unstructured":"Chen AC, Etkin A (2013) Hippocampal network connectivity and activation differentiates post-traumatic stress disorder from generalized anxiety disorder. Neuropsychopharmacology 38:1889\u20131898","journal-title":"Neuropsychopharmacology"},{"key":"2292_CR40","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.jneumeth.2011.10.006","volume":"203","author":"Z-X Zang","year":"2012","unstructured":"Zang Z-X, Yan C-G, Dong Z-Y, Huang J, Zang YF (2012) Granger causality analysis implementation on MATLAB: A graphic user interface toolkit for fMRI data processing. J Neurosci Methods 203:418\u2013426","journal-title":"J Neurosci Methods"},{"key":"2292_CR41","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","volume":"14","author":"CG Yan","year":"2016","unstructured":"Yan CG, Di Wang X, Zuo XN, Zang YF (2016) DPABI: Data Processing & Analysis for (resting-state) brain imaging. Neuroinformatics 14:339\u2013351","journal-title":"Neuroinformatics"},{"key":"2292_CR42","doi-asserted-by":"crossref","unstructured":"Tiraboschi P, Hansen LA, Masliah E,\u00a0Alford M, Thal LJ, Corey-Bloom J\u00a0(2004) Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease. Neurology 62:1977\u20131983","DOI":"10.1212\/01.WNL.0000128091.92139.0F"},{"key":"2292_CR43","doi-asserted-by":"crossref","unstructured":"Chang L, Douet V, Bloss C,\u00a0Lee K, Pritchett A, Jernigan TL, Akshoomoff N, Murray SS et al (2016) Gray matter maturation and cognition in children with different APOE \u03f5 genotypes. Neurology 87:585\u2013594","DOI":"10.1212\/WNL.0000000000002939"},{"key":"2292_CR44","doi-asserted-by":"crossref","unstructured":"Zerbi V, Wiesmann M, Emmerzaal TL,\u00a0Jansen D, van Beek M, Mutsaers MPC, Beckmann CF, Heerschap A et al\u00a0(2014) Resting-state functional connectivity changes in aging apoE4 and apoE-KO mice. J Neurosci 34:13963\u201313975","DOI":"10.1523\/JNEUROSCI.0684-14.2014"},{"key":"2292_CR45","doi-asserted-by":"crossref","unstructured":"Montagne A, Nation DA, Sagare AP,\u00a0Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E et al\u00a0(2020) APOE4 leads to blood\u2013brain barrier dysfunction predicting cognitive decline. Nature 581:71\u201376","DOI":"10.1038\/s41586-020-2247-3"},{"key":"2292_CR46","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropsychologia.2016.04.004","volume":"86","author":"L Zamora","year":"2016","unstructured":"Zamora L, Corina D, Ojemann G (2016) Human temporal cortical single neuron activity during working memory maintenance. Neuropsychologia 86:1\u201312","journal-title":"Neuropsychologia"},{"key":"2292_CR47","doi-asserted-by":"crossref","unstructured":"Myers N, Pasquini L, G\u00f6ttler J, Grimmer T, Koch K, Ortner M, Neitzel J, M\u00fchlau M et al (2014) Within-patient correspondence of amyloid-\u03b2 and intrinsic network connectivity in Alzheimer\u2019s disease. Brain 137:2052\u20132064","DOI":"10.1093\/brain\/awu103"},{"key":"2292_CR48","doi-asserted-by":"crossref","unstructured":"Harrison TM, Maass A, Adams JN, Du R, Baker SL, Jagust WJ\u00a0(2019) Tau deposition is associated with functional isolation of the hippocampus in aging. Nat Commun 10(1):4900","DOI":"10.1038\/s41467-019-12921-z"},{"key":"2292_CR49","doi-asserted-by":"crossref","unstructured":"Koch G, Di Lorenzo F, Loizzo S, Motta C, Travaglione S, Baiula M, Rimondini R, Ponzo V et al\u00a0(2017) CSF tau is associated with impaired cortical plasticity, cognitive decline and astrocyte survival only in APOE4-positive Alzheimer\u2019s disease. Sci Rep 7:1\u201312","DOI":"10.1038\/s41598-017-14204-3"},{"key":"2292_CR50","doi-asserted-by":"crossref","unstructured":"Motta C, Finardi A, Toniolo S, Di Lorenzo F, Scaricamazza E, Loizzo S, Mercuri NB, Furlan R et al\u00a0(2020) Protective role of cerebrospinal fluid inflammatory cytokines in patients with amnestic mild cognitive impairment and early Alzheimer\u2019s disease carrying apolipoprotein E4 genotype. J Alzheimers Dis 76(2):681\u2013689","DOI":"10.3233\/JAD-191250"},{"key":"2292_CR51","doi-asserted-by":"crossref","unstructured":"Turney IC, Chesebro AG, Renter\u00eda MA, Lao PJ, Beato JM, Schupf N, Mayeux R, Manly JJ et al\u00a0(2020) APOE \u03b5 4 and resting-state functional connectivity in racially\/ethnically diverse older adults. Alzheimers Dement (Amst) 12(1):e12094","DOI":"10.1002\/dad2.12094"},{"key":"2292_CR52","doi-asserted-by":"crossref","unstructured":"Chiesa PA, Cavedo E, Vergallo A,\u00a0Lista S, Potier MC, Habert MO, Dubois B, Thiebaut de Schotten M et al (2019) Differential default mode network trajectories in asymptomatic individuals at risk for Alzheimer\u2019s disease. Alzheimers Dement 15:940\u2013950","DOI":"10.1016\/j.jalz.2019.03.006"},{"key":"2292_CR53","doi-asserted-by":"crossref","unstructured":"Palesi F, De Rinaldis A, Vitali P, Castellazzi G, Casiraghi L, Germani G, Bernini S, Anzalone N et al\u00a0(2018) Specific patterns of white matter alterations help distinguishing Alzheimer\u2019s and vascular dementia. Front Neurosci 12:274","DOI":"10.3389\/fnins.2018.00274"},{"key":"2292_CR54","doi-asserted-by":"crossref","unstructured":"Hodgetts CJ, Shine JP, Williams H, Postans M, Sims R, Williams J, Lawrence AD, Graham KS\u00a0(2019) Increased posterior default mode network activity and structural connectivity in young adult APOE-\u03b54 carriers: a multimodal imaging investigation. Neurobiol Aging 3:82\u201391","DOI":"10.1016\/j.neurobiolaging.2018.08.026"},{"key":"2292_CR55","doi-asserted-by":"crossref","unstructured":"Mart\u00ed-Juan G, Sanroma-Guell G, Cacciaglia R,\u00a0Falcon C, Operto G, Molinuevo JL, Gonz\u00e1lez Ballester M\u00c1, Gispert JD et al (2020) Nonlinear interaction between APOE \u03b5 4 allele load and age in the hippocampal surface of cognitively intact individuals. Hum Brain Mapp 42(1):47\u201364","DOI":"10.1002\/hbm.25202"},{"key":"2292_CR56","doi-asserted-by":"publisher","first-page":"4331","DOI":"10.1002\/hbm.24705","volume":"40","author":"J Li","year":"2019","unstructured":"Li J, Biswal BB, Wang P, Duan X, Cui Q, Chen H, Liao W (2019) Exploring the functional connectome in white matter. Hum Brain Mapp 40:4331\u20134344","journal-title":"Hum Brain Mapp"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02292-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02292-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02292-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T00:24:16Z","timestamp":1724372656000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02292-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,26]]},"references-count":56,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["2292"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02292-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,26]]},"assertion":[{"value":"3 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 January 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declaration"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the local Medical Research Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate\/publication"}},{"value":"All authors have no conflict of interest to disclose.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}