{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T21:21:07Z","timestamp":1792790467159,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council\u00a0of\u00a0Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["Award No-09\/1051(0029)\/2 019-EMR-1"],"award-info":[{"award-number":["Award No-09\/1051(0029)\/2 019-EMR-1"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s12035-021-02386-x","type":"journal-article","created":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T15:46:17Z","timestamp":1618501577000},"page":"3874-3883","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies"],"prefix":"10.1007","volume":"58","author":[{"given":"Palvi","family":"Gotra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nidhi","family":"Bhardwaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhilash","family":"Ludhiadch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gagandeep","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-8592","authenticated-orcid":false,"given":"Anjana","family":"Munshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"issue":"10 Suppl 7","key":"2386_CR1","first-page":"S28","volume":"44","author":"RB Lipton","year":"1994","unstructured":"Lipton RB, Ottman R, Ehrenberg BL, Hauser WA (1994) Comorbidity of migraine: the connection between migraine and epilepsy. Neurology 44(10 Suppl 7):S28\u2013S32","journal-title":"Neurology"},{"issue":"12","key":"2386_CR2","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1111\/j.1528-1167.2005.00344.x","volume":"46","author":"JF T\u00e9llez-Zenteno","year":"2005","unstructured":"T\u00e9llez-Zenteno JF, Matijevic S, Wiebe S (2005) Somatic comorbidity of epilepsy in the general population in Canada. Epilepsia 46(12):1955\u20131962","journal-title":"Epilepsia"},{"issue":"3","key":"2386_CR3","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1007\/s10194-011-0344-2","volume":"12","author":"PT Davies","year":"2011","unstructured":"Davies PT, Panayiotopoulos C (2011) Migraine triggered seizures and epilepsy triggered headache and migraine attacks: a need for re-assessment. J Headache Pain 12(3):287\u2013288","journal-title":"J Headache Pain"},{"issue":"11","key":"2386_CR4","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/s41582-019-0255-4","volume":"15","author":"EC Gross","year":"2019","unstructured":"Gross EC, Lisicki M, Fischer D, S\u00e1ndor PS, Schoenen J (2019) The metabolic face of migraine\u2014from pathophysiology to treatment. Nat Rev Neurol 15(11):627\u2013643","journal-title":"Nat Rev Neurol"},{"issue":"8","key":"2386_CR5","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/nrneurol.2016.93","volume":"12","author":"A May","year":"2016","unstructured":"May A, Schulte LH (2016) Chronic migraine: risk factors, mechanisms and treatment. Nat Rev Neurol 12(8):455\u2013464","journal-title":"Nat Rev Neurol"},{"key":"2386_CR6","doi-asserted-by":"crossref","unstructured":"Hauser WA (1999) Risk factors for epilepsy. In: The Epilepsies. Elsevier, pp 1-11","DOI":"10.1016\/B978-012422150-5\/50002-0"},{"issue":"2","key":"2386_CR7","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0022-3956(93)90009-Q","volume":"27","author":"N Breslau","year":"1993","unstructured":"Breslau N, Davis GC (1993) Migraine, physical health and psychiatric disorder: a prospective epidemiologic study in young adults. J Psychiatr Res 27(2):211\u2013221","journal-title":"J Psychiatr Res"},{"issue":"1","key":"2386_CR8","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s10072-017-2902-0","volume":"38","author":"D Zarcone","year":"2017","unstructured":"Zarcone D, Corbetta S (2017) Shared mechanisms of epilepsy, migraine and affective disorders. Neurol Sci 38(1):73\u201376","journal-title":"Neurol Sci"},{"issue":"2","key":"2386_CR9","first-page":"14","volume":"11","author":"SA Jasim","year":"2019","unstructured":"Jasim SA, Al-Obaidy AM, Rabeea AK (2019) Relationship of migraine in epileptic patients. Al-Kufa Univ J Biol 11(2):14\u201319","journal-title":"Al-Kufa Univ J Biol"},{"key":"2386_CR10","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1093\/med\/9780199552764.003.0020","volume":"16","author":"MA Rogawski","year":"2008","unstructured":"Rogawski MA (2008) Antiepileptic drugs and migraine. Innov Drug Dev Headache Disorders 16:153\u2013178","journal-title":"Innov Drug Dev Headache Disorders"},{"issue":"20","key":"2386_CR11","doi-asserted-by":"publisher","first-page":"13284","DOI":"10.1073\/pnas.192242399","volume":"99","author":"A Tottene","year":"2002","unstructured":"Tottene A, Fellin T, Pagnutti S, Luvisetto S, Striessnig J, Fletcher C, Pietrobon D (2002) Familial hemiplegic migraine mutations increase Ca(2+) influx through single human CaV2.1 channels and decrease maximal CaV2.1 current density in neurons. Proc Natl Acad Sci U S A 99(20):13284\u201313289. https:\/\/doi.org\/10.1073\/pnas.192242399","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9483","key":"2386_CR12","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1016\/S0140-6736(05)66786-4","volume":"366","author":"M Dichgans","year":"2005","unstructured":"Dichgans M, Freilinger T, Eckstein G, Babini E, Lorenz-Depiereux B, Biskup S, Ferrari MD, Herzog J et al (2005) Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet 366(9483):371\u2013377","journal-title":"Lancet"},{"issue":"3","key":"2386_CR13","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/ana.10674","volume":"54","author":"KR Vanmolkot","year":"2003","unstructured":"Vanmolkot KR, Kors EE, Hottenga JJ, Terwindt GM, Haan J, Hoefnagels WA, Black DF, Sandkuijl LA et al (2003) Novel mutations in the Na+, K+-ATPase pump gene ATP1A2 associated with familial hemiplegic migraine and benign familial infantile convulsions. Ann Neurol 54(3):360\u2013366. https:\/\/doi.org\/10.1002\/ana.10674","journal-title":"Ann Neurol"},{"key":"2386_CR14","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.eplepsyres.2019.03.001","volume":"152","author":"P Perucca","year":"2019","unstructured":"Perucca P, Perucca E (2019) Identifying mutations in epilepsy genes: impact on treatment selection. Epilepsy Res 152:18\u201330","journal-title":"Epilepsy Res"},{"issue":"1","key":"2386_CR15","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1124\/pr.117.014456","volume":"70","author":"J Oyrer","year":"2018","unstructured":"Oyrer J, Maljevic S, Scheffer IE, Berkovic SF, Petrou S, Reid CA (2018) Ion channels in genetic epilepsy: from genes and mechanisms to disease-targeted therapies. Pharmacol Rev 70(1):142\u2013173","journal-title":"Pharmacol Rev"},{"issue":"2","key":"2386_CR16","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/0333102416686347","volume":"38","author":"P Prontera","year":"2018","unstructured":"Prontera P, Sarchielli P, Caproni S, Bedetti C, Cupini L, Calabresi P, Costa C (2018) Epilepsy in hemiplegic migraine: genetic mutations and clinical implications. Cephalalgia 38(2):361\u2013373","journal-title":"Cephalalgia"},{"key":"2386_CR17","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.neulet.2017.11.025","volume":"667","author":"M Mantegazza","year":"2018","unstructured":"Mantegazza M, Cestele S (2018) Pathophysiological mechanisms of migraine and epilepsy: similarities and differences. Neurosci Lett 667:92\u2013102. https:\/\/doi.org\/10.1016\/j.neulet.2017.11.025","journal-title":"Neurosci Lett"},{"issue":"1","key":"2386_CR18","doi-asserted-by":"publisher","first-page":"7","DOI":"10.14581\/jer.17002","volume":"7","author":"DW Kim","year":"2017","unstructured":"Kim DW, Lee SK (2017) Headache and epilepsy. J Epilepsy Res 7(1):7\u201315","journal-title":"J Epilepsy Res"},{"issue":"10","key":"2386_CR19","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1111\/j.1468-2982.2009.01983.x","volume":"29","author":"A Charles","year":"2009","unstructured":"Charles A, Brennan K (2009) Cortical spreading depression\u2014new insights and persistent questions. Cephalalgia 29(10):1115\u20131124","journal-title":"Cephalalgia"},{"issue":"3","key":"2386_CR20","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1080\/01616412.2018.1428406","volume":"40","author":"P Borgdorff","year":"2018","unstructured":"Borgdorff P (2018) Arguments against the role of cortical spreading depression in migraine. Neurol Res 40(3):173\u2013181","journal-title":"Neurol Res"},{"issue":"9","key":"2386_CR21","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1177\/0333102417738249","volume":"38","author":"M Unekawa","year":"2018","unstructured":"Unekawa M, Ikeda K, Tomita Y, Kawakami K, Suzuki N (2018) Enhanced susceptibility to cortical spreading depression in two types of Na+, K+-ATPase \u03b12 subunit-deficient mice as a model of familial hemiplegic migraine 2. Cephalalgia 38(9):1515\u20131524","journal-title":"Cephalalgia"},{"issue":"4","key":"2386_CR22","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s11940-019-0558-1","volume":"21","author":"SK Parikh","year":"2019","unstructured":"Parikh SK, Silberstein SD (2019) Current status of antiepileptic drugs as preventive migraine therapy. Curr Treat Options Neurol 21(4):16","journal-title":"Curr Treat Options Neurol"},{"key":"2386_CR23","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.heares.2014.11.006","volume":"319","author":"CG Inchauspe","year":"2015","unstructured":"Inchauspe CG, Pilati N, Di Guilmi MN, Urbano FJ, Ferrari MD, van den Maagdenberg AM, Forsythe ID, Uchitel OD (2015) Familial hemiplegic migraine type-1 mutated cav2. 1 calcium channels alter inhibitory and excitatory synaptic transmission in the lateral superior olive of mice. Hear Res 319:56\u201368","journal-title":"Hear Res"},{"issue":"7","key":"2386_CR24","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1089\/neu.2006.23.1083","volume":"23","author":"K Zweckberger","year":"2006","unstructured":"Zweckberger K, Er\u00f6s C, Zimmermann R, Kim S-W, Engel D, Plesnila N (2006) Effect of early and delayed decompressive craniectomy on secondary brain damage after controlled cortical impact in mice. J Neurotrauma 23(7):1083\u20131093","journal-title":"J Neurotrauma"},{"issue":"3","key":"2386_CR25","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1528-1167.2007.01415.x","volume":"49","author":"L Deprez","year":"2008","unstructured":"Deprez L, Weckhuysen S, Peeters K, Deconinck T, Claeys KG, Claes LR, Suls A, Van Dyck T et al (2008) Epilepsy as part of the phenotype associated with ATP1A2 mutations. Epilepsia 49(3):500\u2013508","journal-title":"Epilepsia"},{"issue":"3","key":"2386_CR26","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/head.12781","volume":"56","author":"F Bagnato","year":"2016","unstructured":"Bagnato F, Good J (2016) The use of antiepileptics in migraine prophylaxis. Headache: The Journal of Head and Face Pain 56(3):603\u2013615","journal-title":"Headache: The Journal of Head and Face Pain"},{"key":"2386_CR27","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1007\/s40272-020-00418-y","volume":"22","author":"J Kacperski","year":"2020","unstructured":"Kacperski J, Green A, Qaiser S (2020) Management of chronic migraine in children and adolescents: a brief discussion on preventive therapies. Pediatr Drugs 22:635\u2013643 1-9","journal-title":"Pediatr Drugs"},{"key":"2386_CR28","doi-asserted-by":"crossref","unstructured":"Shahien R, Beiruti K (2012) Preventive agents for migraine: focus on the antiepileptic drugs. Journal of Central Nervous System Disease 4:JCNSD. S9049","DOI":"10.4137\/JCNSD.S9049"},{"issue":"4","key":"2386_CR29","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1097\/FPC.0b013e32835ea0b2","volume":"23","author":"Y Ghodke-Puranik","year":"2013","unstructured":"Ghodke-Puranik Y, Thorn CF, Lamba JK, Leeder JS, Song W, Birnbaum AK, Altman RB, Klein TE (2013) Valproic acid pathway: pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics 23(4):236\u2013241. https:\/\/doi.org\/10.1097\/FPC.0b013e32835ea0b2","journal-title":"Pharmacogenet Genomics"},{"key":"2386_CR30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2147\/ndt.s6459","volume":"6","author":"S Naegel","year":"2010","unstructured":"Naegel S, Obermann M (2010) Topiramate in the prevention and treatment of migraine: efficacy, safety and patient preference. Neuropsychiatr Dis Treat 6:17\u201328. https:\/\/doi.org\/10.2147\/ndt.s6459","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"2386_CR31","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1097\/FPC.0000000000000397","volume":"30","author":"T Mitra-Ghosh","year":"2020","unstructured":"Mitra-Ghosh T, Callisto SP, Lamba JK, Remmel RP, Birnbaum AK, Barbarino JM, Klein TE, Altman RB (2020) PharmGKB summary: lamotrigine pathway, pharmacokinetics and pharmacodynamics. Pharmacogenet Genomics 30(4):81\u201390. https:\/\/doi.org\/10.1097\/FPC.0000000000000397","journal-title":"Pharmacogenet Genomics"},{"issue":"5","key":"2386_CR32","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1111\/epi.12123","volume":"54","author":"S Cestele","year":"2013","unstructured":"Cestele S, Labate A, Rusconi R, Tarantino P, Mumoli L, Franceschetti S, Annesi G, Mantegazza M et al (2013) Divergent effects of the T1174S SCN1A mutation associated with seizures and hemiplegic migraine. Epilepsia 54(5):927\u2013935. https:\/\/doi.org\/10.1111\/epi.12123","journal-title":"Epilepsia"},{"issue":"3","key":"2386_CR33","first-page":"22","volume":"1","author":"L Sun","year":"2016","unstructured":"Sun L, Lutz BM, Tao Y-X (2016) The CRISPR\/Cas9 system for gene editing and its potential application in pain research. Transl Perioper Pain Med 1(3):22\u201333","journal-title":"Transl Perioper Pain Med"},{"issue":"1","key":"2386_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41398-020-01108-6","volume":"10","author":"K Fujihara","year":"2020","unstructured":"Fujihara K, Yamada K, Ichitani Y, Kakizaki T, Jiang W, Miyata S, Suto T, Kato D et al (2020) CRISPR\/Cas9-engineered Gad1 elimination in rats leads to complex behavioral changes: implications for schizophrenia. Transl Psychiatry 10(1):1\u201313","journal-title":"Transl Psychiatry"},{"issue":"1","key":"2386_CR35","doi-asserted-by":"publisher","first-page":"e703","DOI":"10.1038\/tp.2015.203","volume":"6","author":"J Liu","year":"2016","unstructured":"Liu J, Gao C, Chen W, Ma W, Li X, Shi Y, Zhang H, Zhang L et al (2016) CRISPR\/Cas9 facilitates investigation of neural circuit disease using human iPSCs: mechanism of epilepsy caused by an SCN1A loss-of-function mutation. Transl Psychiatry 6(1):e703\u2013e703","journal-title":"Transl Psychiatry"},{"issue":"6","key":"2386_CR36","doi-asserted-by":"publisher","first-page":"468","DOI":"10.3109\/07853890.2015.1071871","volume":"47","author":"E Tafuri","year":"2015","unstructured":"Tafuri E, Santovito D, de Nardis V, Marcantonio P, Paganelli C, Affaitati G, Bucci M, Mezzetti A et al (2015) MicroRNA profiling in migraine without aura: pilot study. Ann Med 47(6):468\u2013473","journal-title":"Ann Med"},{"issue":"13","key":"2386_CR37","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1177\/0333102415608360","volume":"36","author":"C Fan","year":"2016","unstructured":"Fan C, Wolking S, Lehmann-Horn F, Hedrich UB, Freilinger T, Lerche H, Borck G, Kubisch C et al (2016) Early-onset familial hemiplegic migraine due to a novel SCN1A mutation. Cephalalgia 36(13):1238\u20131247","journal-title":"Cephalalgia"},{"issue":"2","key":"2386_CR38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1080\/07853890.2016.1226515","volume":"49","author":"C Tana","year":"2017","unstructured":"Tana C, Giamberardino MA, Cipollone F (2017) microRNA profiling in atherosclerosis, diabetes, and migraine. Ann Med 49(2):93\u2013105","journal-title":"Ann Med"},{"issue":"9","key":"2386_CR39","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1177\/0333102417742375","volume":"38","author":"C-Y Cheng","year":"2018","unstructured":"Cheng C-Y, Chen S-P, Liao Y-C, Fuh J-L, Wang Y-F, Wang S-J (2018) Elevated circulating endothelial-specific microRNAs in migraine patients: a pilot study. Cephalalgia 38(9):1585\u20131591","journal-title":"Cephalalgia"},{"issue":"1","key":"2386_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s10194-020-01189-0","volume":"21","author":"R Greco","year":"2020","unstructured":"Greco R, De Icco R, Demartini C, Zanaboni AM, Tumelero E, Sances G, Allena M, Tassorelli C (2020) Plasma levels of CGRP and expression of specific microRNAs in blood cells of episodic and chronic migraine subjects: towards the identification of a panel of peripheral biomarkers of migraine? J Headache Pain 21(1):1\u201312","journal-title":"J Headache Pain"},{"issue":"4","key":"2386_CR41","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1111\/ene.14129","volume":"27","author":"R Martins-Ferreira","year":"2020","unstructured":"Martins-Ferreira R, Chaves J, Carvalho C, Bettencourt A, Chor\u00e3o R, Freitas J, Sam\u00f5es R, Boleixa D et al (2020) Circulating microRNAs as potential biomarkers for genetic generalized epilepsies: a three microRNA panel. Eur J Neurol 27(4):660\u2013666","journal-title":"Eur J Neurol"},{"issue":"4","key":"2386_CR42","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1002\/mgg3.24","volume":"1","author":"O Carre\u00f1o","year":"2013","unstructured":"Carre\u00f1o O, Corominas R, Serra SA, Sintas C, Fern\u00e1ndez-Castillo N, Vila-Pueyo M, Toma C, Gen\u00e9 GG et al (2013) Screening of CACNA1A and ATP1A2 genes in hemiplegic migraine: clinical, genetic, and functional studies. Mol Gen Genomic Med 1(4):206\u2013222","journal-title":"Mol Gen Genomic Med"},{"issue":"12","key":"2386_CR43","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1177\/0333102418761041","volume":"38","author":"ME Hiekkala","year":"2018","unstructured":"Hiekkala ME, Vuola P, Artto V, H\u00e4pp\u00f6l\u00e4 P, H\u00e4pp\u00f6l\u00e4 E, Veps\u00e4l\u00e4inen S, Cuenca-Leon E, Lal D et al (2018) The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: a clinical and genetic study in Finnish migraine families. Cephalalgia 38(12):1849\u20131863","journal-title":"Cephalalgia"},{"key":"2386_CR44","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.eplepsyres.2006.01.019","volume":"70","author":"T Fujiwara","year":"2006","unstructured":"Fujiwara T (2006) Clinical spectrum of mutations in SCN1A gene: severe myoclonic epilepsy in infancy and related epilepsies. Epilepsy Res 70:223\u2013230","journal-title":"Epilepsy Res"},{"issue":"3","key":"2386_CR45","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1016\/j.celrep.2017.12.056","volume":"22","author":"J Coleman","year":"2018","unstructured":"Coleman J, Jouannot O, Ramakrishnan SK, Zanetti MN, Wang J, Salpietro V, Houlden H, Rothman JE et al (2018) PRRT2 regulates synaptic fusion by directly modulating SNARE complex assembly. Cell Rep 22(3):820\u2013831","journal-title":"Cell Rep"},{"issue":"21","key":"2386_CR46","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.1212\/WNL.0b013e3182752ca2","volume":"79","author":"C Marini","year":"2012","unstructured":"Marini C, Conti V, Mei D, Battaglia D, Lettori D, Losito E, Bruccini G, Tortorella G et al (2012) PRRT2 mutations in familial infantile seizures, paroxysmal dyskinesia, and hemiplegic migraine. Neurology 79(21):2109\u20132114","journal-title":"Neurology"},{"issue":"6","key":"2386_CR47","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.pediatrneurol.2007.06.016","volume":"37","author":"JJ Gargus","year":"2007","unstructured":"Gargus JJ, Tournay A (2007) Novel mutation confirms seizure locus SCN1A is also familial hemiplegic migraine locus FHM3. Pediatr Neurol 37(6):407\u2013410","journal-title":"Pediatr Neurol"},{"issue":"2","key":"2386_CR48","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.pediatrneurol.2009.09.007","volume":"42","author":"PS Dimova","year":"2010","unstructured":"Dimova PS, Yordanova I, Bojinova V, Jordanova A, Kremenski I (2010) Generalized epilepsy with febrile seizures plus: novel SCN1A mutation. Pediatr Neurol 42(2):137\u2013140","journal-title":"Pediatr Neurol"},{"issue":"4","key":"2386_CR49","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1038\/74159","volume":"24","author":"A Escayg","year":"2000","unstructured":"Escayg A, MacDonald BT, Meisler MH, Baulac S, Huberfeld G, An-Gourfinkel I, Brice A, LeGuern E et al (2000) Mutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+ 2. Nat Genet 24(4):343\u2013345","journal-title":"Nat Genet"},{"issue":"9","key":"2386_CR50","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1111\/j.1528-1167.2010.02640.x","volume":"51","author":"A Escayg","year":"2010","unstructured":"Escayg A, Goldin AL (2010) Sodium channel SCN1A and epilepsy: mutations and mechanisms. Epilepsia 51(9):1650\u20131658","journal-title":"Epilepsia"},{"issue":"43","key":"2386_CR51","doi-asserted-by":"publisher","first-page":"17546","DOI":"10.1073\/pnas.1309827110","volume":"110","author":"S Cest\u00e8le","year":"2013","unstructured":"Cest\u00e8le S, Schiavon E, Rusconi R, Franceschetti S, Mantegazza M (2013) Nonfunctional NaV1. 1 familial hemiplegic migraine mutant transformed into gain of function by partial rescue of folding defects. Proc Natl Acad Sci 110(43):17546\u201317551","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"2386_CR52","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/humu.9486","volume":"28","author":"KR Vanmolkot","year":"2007","unstructured":"Vanmolkot KR, Babini E, de Vries B, Stam AH, Freilinger T, Terwindt GM, Norris L, Haan J et al (2007) The novel p. L1649Q mutation in the SCN1A epilepsy gene is associated with familial hemiplegic migraine: genetic and functional studies. Hum Mutat 28(5):522\u2013522","journal-title":"Hum Mutat"},{"issue":"13","key":"2386_CR53","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1177\/0333102414529195","volume":"34","author":"CM Weller","year":"2014","unstructured":"Weller CM, Pelzer N, de Vries B, L\u00f3pez MA, De F\u00e0bregues O, Pascual J, Arroyo MAR, Koelewijn SC et al (2014) Two novel SCN1A mutations identified in families with familial hemiplegic migraine. Cephalalgia 34(13):1062\u20131069","journal-title":"Cephalalgia"},{"issue":"2","key":"2386_CR54","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.gendis.2018.04.007","volume":"5","author":"J Liao","year":"2018","unstructured":"Liao J, Tian X, Wang H, Xiao Z (2018) Epilepsy and migraine\u2014are they comorbidity? Genes Diseases 5(2):112\u2013118","journal-title":"Genes Diseases"},{"issue":"4","key":"2386_CR55","first-page":"424","volume":"50","author":"ND Lestari","year":"2018","unstructured":"Lestari ND, Mutiawati E, Sadewa AH, Sjahrir H, Syahrul DRE, Harapan H (2018) SCN1A exon 26 variants in epilepsy and migraine patients. J Med Sci 50(4):424\u2013430","journal-title":"J Med Sci"},{"issue":"13","key":"2386_CR56","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1212\/01.wnl.0000345393.53132.8c","volume":"72","author":"K Vahedi","year":"2009","unstructured":"Vahedi K, Depienne C, Le Fort D, Riant F, Chaine P, Trouillard O, Gaudric A, Morris M et al (2009) Elicited repetitive daily blindness: a new phenotype associated with hemiplegic migraine and SCN1A mutations. Neurology 72(13):1178\u20131183","journal-title":"Neurology"},{"issue":"3","key":"2386_CR57","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1111\/j.1468-2982.2008.01721.x","volume":"29","author":"M Castro","year":"2009","unstructured":"Castro M, Stam A, Lemos C, De Vries B, Vanmolkot K, Barros J, Terwindt G, Frants R et al (2009) First mutation in the voltage-gated Nav1. 1 subunit gene SCN1A with co-occurring familial hemiplegic migraine and epilepsy. Cephalalgia 29(3):308\u2013313","journal-title":"Cephalalgia"},{"issue":"6","key":"2386_CR58","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1111\/j.1476-5381.2010.00976.x","volume":"161","author":"KM Kahlig","year":"2010","unstructured":"Kahlig KM, Lepist I, Leung K, Rajamani S, George AL (2010) Ranolazine selectively blocks persistent current evoked by epilepsy-associated NaV1. 1 mutations. Br J Pharmacol 161(6):1414\u20131426","journal-title":"Br J Pharmacol"},{"issue":"45","key":"2386_CR59","doi-asserted-by":"publisher","first-page":"14874","DOI":"10.1523\/JNEUROSCI.0721-14.2014","volume":"34","author":"UB Hedrich","year":"2014","unstructured":"Hedrich UB, Liautard C, Kirschenbaum D, Pofahl M, Lavigne J, Liu Y, Theiss S, Slotta J et al (2014) Impaired action potential initiation in GABAergic interneurons causes hyperexcitable networks in an epileptic mouse model carrying a human NaV1. 1 mutation. J Neurosci 34(45):14874\u201314889","journal-title":"J Neurosci"},{"issue":"12","key":"2386_CR60","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1177\/0333102414527015","volume":"34","author":"J Barros","year":"2014","unstructured":"Barros J, Ferreira A, Brand\u00e3o AF, Lemos C, Correia F, Dam\u00e1sio J, Tuna A, Sequeiros J et al (2014) Familial hemiplegic migraine due to L263V SCN1A mutation: discordance for epilepsy between two kindreds from Douro Valley. Cephalalgia 34(12):1015\u20131020","journal-title":"Cephalalgia"},{"issue":"11","key":"2386_CR61","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1113\/jphysiol.2009.186437","volume":"588","author":"S Rajakulendran","year":"2010","unstructured":"Rajakulendran S, Graves TD, Labrum RW, Kotzadimitriou D, Eunson L, Davis MB, Davies R, Wood NW et al (2010) Genetic and functional characterisation of the P\/Q calcium channel in episodic ataxia with epilepsy. J Physiol 588(11):1905\u20131913","journal-title":"J Physiol"},{"issue":"9","key":"2386_CR62","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/s41582-020-0369-8","volume":"16","author":"GP Brennan","year":"2020","unstructured":"Brennan GP, Henshall DC (2020) MicroRNAs as regulators of brain function and targets for treatment of epilepsy. Nat Rev Neurol 16(9):506\u2013519","journal-title":"Nat Rev Neurol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02386-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02386-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02386-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T04:45:22Z","timestamp":1626324322000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02386-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,15]]},"references-count":62,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["2386"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02386-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,15]]},"assertion":[{"value":"20 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 April 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}