{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T23:11:34Z","timestamp":1789341094032,"version":"build-2803163510"},"reference-count":131,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,5,19]],"date-time":"2021-05-19T00:00:00Z","timestamp":1621382400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81871068, No.81671352, No.91232709"],"award-info":[{"award-number":["No.81871068, No.81671352, No.91232709"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Joint Fund for Science and Technology Innovation of Fujian","award":["No.2018Y9057"],"award-info":[{"award-number":["No.2018Y9057"]}]},{"name":"Startup Fund for Scientific Research of Fujian Medical University","award":["No.2019QH2014"],"award-info":[{"award-number":["No.2019QH2014"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1007\/s12035-021-02427-5","type":"journal-article","created":{"date-parts":[[2021,5,20]],"date-time":"2021-05-20T07:08:20Z","timestamp":1621494500000},"page":"4348-4364","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["The Roles of Peroxiredoxin 6 in Brain Diseases"],"prefix":"10.1007","volume":"58","author":[{"given":"Jiangfeng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4037-9855","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,5,19]]},"reference":[{"issue":"3","key":"2427_CR1","doi-asserted-by":"publisher","first-page":"831","DOI":"10.1089\/ars.2010.3412","volume":"15","author":"AB Fisher","year":"2011","unstructured":"Fisher AB (2011) Prdx6: a bifunctional enzyme with GSH peroxidase and PLA2 activities. Antioxid Redox Sign 15(3):831\u2013844. https:\/\/doi.org\/10.1089\/ars.2010.3412","journal-title":"Antioxid Redox Sign"},{"issue":"3","key":"2427_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1089\/ars.2017.7427","volume":"30","author":"F Pacifici","year":"2019","unstructured":"Pacifici F, Della Morte D, Capuani B, Pastore D, Bellia A, Sbraccia P, Di Daniele N, Lauro R et al (2019) Peroxiredoxin6, a multitask antioxidant enzyme involved in the pathophysiology of chronic noncommunicable diseases. Antioxid Redox Sign 30(3):399\u2013414. https:\/\/doi.org\/10.1089\/ars.2017.7427","journal-title":"Antioxid Redox Sign"},{"issue":"4","key":"2427_CR3","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1194\/jlr.M064758","volume":"57","author":"AB Fisher","year":"2016","unstructured":"Fisher AB, Dodia C, Sorokina EM, Li H, Zhou S, Raabe T, Feinstein SI (2016) A novel lysophosphatidylcholine acyl transferase activity is expressed by peroxiredoxin 6. J Lipid Res 57(4):587\u2013596. https:\/\/doi.org\/10.1194\/jlr.M064758","journal-title":"J Lipid Res"},{"issue":"1","key":"2427_CR4","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13024-020-00401-8","volume":"15","author":"JE Pankiewicz","year":"2020","unstructured":"Pankiewicz JE, Diaz JR, Marta-Ariza M, Lizinczyk AM, Franco LA, Sadowski MJ (2020) Peroxiredoxin 6 mediates protective function of astrocytes in Abeta proteostasis. Mol Neurodegener 15(1):50. https:\/\/doi.org\/10.1186\/s13024-020-00401-8","journal-title":"Mol Neurodegener"},{"issue":"3","key":"2427_CR5","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s12035-013-8479-6","volume":"48","author":"HM Yun","year":"2013","unstructured":"Yun HM, Jin P, Han JY, Lee MS, Han SB, Oh KW, Hong SH, Jung EY et al (2013) Acceleration of the development of Alzheimer\u2019s disease in amyloid beta-infused peroxiredoxin 6 overexpression transgenic mice. Mol Neurobiol 48(3):941\u2013951. https:\/\/doi.org\/10.1007\/s12035-013-8479-6","journal-title":"Mol Neurobiol"},{"issue":"5","key":"2427_CR6","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.1007\/s12035-018-1287-2","volume":"56","author":"IJ Yeo","year":"2019","unstructured":"Yeo IJ, Park MH, Son DJ, Kim JY, Nam KT, Hyun BK, Kim SY, Jung MH et al (2019) PRDX6 inhibits neurogenesis through downregulation of WDFY1-mediated TLR4 signal. Mol Neurobiol 56(5):3132\u20133144. https:\/\/doi.org\/10.1007\/s12035-018-1287-2","journal-title":"Mol Neurobiol"},{"issue":"6","key":"2427_CR7","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1038\/nm.2749","volume":"18","author":"T Shichita","year":"2012","unstructured":"Shichita T, Hasegawa E, Kimura A, Morita R, Sakaguchi R, Takada I, Sekiya T, Ooboshi H et al (2012) Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain. Nat Med 18(6):911\u2013917. https:\/\/doi.org\/10.1038\/nm.2749","journal-title":"Nat Med"},{"key":"2427_CR8","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3389\/fncel.2017.00099","volume":"11","author":"Y Shanshan","year":"2017","unstructured":"Shanshan Y, Beibei J, Li T, Minna G, Shipeng L, Li P, Yong Z (2017) Phospholipase A2 of Peroxiredoxin 6 plays a critical role in cerebral ischemia\/reperfusion inflammatory injury. Front Cell Neurosci 11:99. https:\/\/doi.org\/10.3389\/fncel.2017.00099","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"2427_CR9","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1194\/jlr.TR119000427","volume":"61","author":"S Grassi","year":"2020","unstructured":"Grassi S, Giussani P, Mauri L, Prioni S, Sonnino S, Prinetti A (2020) Lipid rafts and neurodegeneration: structural and functional roles in physiologic aging and neurodegenerative diseases: thematic review series: biology of lipid rafts. J Lipid Res 61(5):636\u2013654. https:\/\/doi.org\/10.1194\/jlr.TR119000427","journal-title":"J Lipid Res"},{"issue":"3","key":"2427_CR10","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1046\/j.1471-4159.1997.69030889.x","volume":"69","author":"AA Farooqui","year":"1997","unstructured":"Farooqui AA, Yang HC, Rosenberger TA, Horrocks LA (1997) Phospholipase A2 and its role in brain tissue. J Neurochem 69(3):889\u2013901. https:\/\/doi.org\/10.1046\/j.1471-4159.1997.69030889.x","journal-title":"J Neurochem"},{"issue":"6","key":"2427_CR11","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1007\/s00401-008-0373-3","volume":"115","author":"JHT Power","year":"2008","unstructured":"Power JHT, Asad S, Chataway TK, Chegini F, Manavis J, Temlett JA, Jensen PH, Blumbergs PC et al (2008) Prdx6 in human brain: molecular forms, cellular distribution and association with AD pathology. Acta Neuropathol 115(6):611\u2013622. https:\/\/doi.org\/10.1007\/s00401-008-0373-3","journal-title":"Acta Neuropathol"},{"issue":"2","key":"2427_CR12","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1002\/cne.22689","volume":"520","author":"J Goemaere","year":"2012","unstructured":"Goemaere J, Knoops B (2012) Peroxiredoxin distribution in the mouse brain with emphasis on neuronal populations affected in neurodegenerative disorders. J Comp Neurol 520(2):258\u2013280. https:\/\/doi.org\/10.1002\/cne.22689","journal-title":"J Comp Neurol"},{"issue":"10","key":"2427_CR13","doi-asserted-by":"publisher","first-page":"836","DOI":"10.3109\/10715762.2013.833330","volume":"47","author":"IK Kim","year":"2013","unstructured":"Kim IK, Lee KJ, Rhee S, Seo SB, Pak JH (2013) Protective effects of peroxiredoxin 6 overexpression on amyloid beta-induced apoptosis in PC12 cells. Free Radic Res 47(10):836\u2013846. https:\/\/doi.org\/10.3109\/10715762.2013.833330","journal-title":"Free Radic Res"},{"issue":"3","key":"2427_CR14","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0002-9440(10)64249-6","volume":"161","author":"JH Power","year":"2002","unstructured":"Power JH, Shannon JM, Blumbergs PC, Gai WP (2002) Nonselenium glutathione peroxidase in human brain: elevated levels in Parkinson\u2019s disease and dementia with lewy bodies. Am J Pathol 161(3):885\u2013894. https:\/\/doi.org\/10.1016\/S0002-9440(10)64249-6","journal-title":"Am J Pathol"},{"issue":"3","key":"2427_CR15","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neulet.2005.02.048","volume":"381","author":"MH Jin","year":"2005","unstructured":"Jin MH, Lee YH, Kim JM, Sun HN, Moon EY, Shong MH, Kim SU, Lee SH et al (2005) Characterization of neural cell types expressing peroxiredoxins in mouse brain. Neurosci Lett 381(3):252\u2013257. https:\/\/doi.org\/10.1016\/j.neulet.2005.02.048","journal-title":"Neurosci Lett"},{"issue":"6","key":"2427_CR16","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1039\/c4mb00703d","volume":"11","author":"V Correani","year":"2015","unstructured":"Correani V, Di Francesco L, Cera I, Mignogna G, Giorgi A, Mazzanti M, Fumagalli L, Fabrizi C et al (2015) Reversible redox modifications in the microglial proteome challenged by beta amyloid. Mol Biosyst 11(6):1584\u20131593. https:\/\/doi.org\/10.1039\/c4mb00703d","journal-title":"Mol Biosyst"},{"issue":"9","key":"2427_CR17","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1089\/ars.2015.6336","volume":"24","author":"S Ma","year":"2016","unstructured":"Ma S, Zhang X, Zheng L, Li Z, Zhao X, Lai W, Shen H, Lv J et al (2016) Peroxiredoxin 6 is a crucial factor in the initial step of mitochondrial clearance and is upstream of the PINK1-Parkin pathway. Antioxid Redox Signal 24(9):486\u2013501. https:\/\/doi.org\/10.1089\/ars.2015.6336","journal-title":"Antioxid Redox Signal"},{"key":"2427_CR18","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.freeradbiomed.2014.03.028","volume":"71","author":"X Kuang","year":"2014","unstructured":"Kuang X, Wang LF, Yu L, Li YJ, Wang YN, He Q, Chen C, Du JR (2014) Ligustilide ameliorates neuroinflammation and brain injury in focal cerebral ischemia\/reperfusion rats: involvement of inhibition of TLR4\/peroxiredoxin 6 signaling. Free Radic Biol Med 71:165\u2013175. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.03.028","journal-title":"Free Radic Biol Med"},{"key":"2427_CR19","doi-asserted-by":"publisher","unstructured":"Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE et al (2017) Prdx6 mediates G\u03b1i protein-coupled receptor inactivation by cJun kinase. Nat Commun 8(1):743. https:\/\/doi.org\/10.1038\/s41467-017-00791-2","DOI":"10.1038\/s41467-017-00791-2"},{"key":"2427_CR20","doi-asserted-by":"publisher","unstructured":"Patel P, Chatterjee S (2019) Peroxiredoxin6 in endothelial signaling. Antioxidants (Basel) 8(3):63. https:\/\/doi.org\/10.3390\/antiox8030063","DOI":"10.3390\/antiox8030063"},{"key":"2427_CR21","doi-asserted-by":"publisher","unstructured":"Arevalo JA, Vazquez-Medina JP (2018) The role of peroxiredoxin 6 in cell signaling. Antioxidants (Basel) 7(12):172. https:\/\/doi.org\/10.3390\/antiox7120172","DOI":"10.3390\/antiox7120172"},{"issue":"2","key":"2427_CR22","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1042\/BJ20141204","volume":"471","author":"A Schmitt","year":"2015","unstructured":"Schmitt A, Schmitz W, Hufnagel A, Schartl M, Meierjohann S (2015) Peroxiredoxin 6 triggers melanoma cell growth by increasing arachidonic acid-dependent lipid signalling. Biochem J 471(2):267\u2013279. https:\/\/doi.org\/10.1042\/BJ20141204","journal-title":"Biochem J"},{"issue":"27","key":"2427_CR23","doi-asserted-by":"publisher","first-page":"25179","DOI":"10.1074\/jbc.M302706200","volume":"278","author":"X Wang","year":"2003","unstructured":"Wang X, Phelan SA, Forsman-Semb K, Taylor EF, Petros C, Brown A, Lerner CP, Paigen B (2003) Mice with targeted mutation of peroxiredoxin 6 develop normally but are susceptible to oxidative stress. J Biol Chem 278(27):25179\u201325190. https:\/\/doi.org\/10.1074\/jbc.M302706200","journal-title":"J Biol Chem"},{"issue":"9","key":"2427_CR24","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1016\/s0891-5849(03)00462-3","volume":"35","author":"SA Phelan","year":"2003","unstructured":"Phelan SA, Wang X, Wallbrandt P, Forsman-Semb K, Paigen B (2003) Overexpression of Prdx6 reduces H2O2 but does not prevent diet-induced atherosclerosis in the aortic root. Free Radic Biol Med 35(9):1110\u20131120. https:\/\/doi.org\/10.1016\/s0891-5849(03)00462-3","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"2427_CR25","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/s0014-5793(03)01199-2","volume":"555","author":"Y Mo","year":"2003","unstructured":"Mo Y, Feinstein SI, Manevich Y, Zhang Q, Lu L, Ho YS, Fisher AB (2003) 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. Febs Lett 555(2):192\u2013198. https:\/\/doi.org\/10.1016\/s0014-5793(03)01199-2","journal-title":"Febs Lett"},{"key":"2427_CR26","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.freeradbiomed.2015.06.009","volume":"87","author":"H Li","year":"2015","unstructured":"Li H, Benipal B, Zhou S, Dodia C, Chatterjee S, Tao JQ, Sorokina EM, Raabe T et al (2015) Critical role of peroxiredoxin 6 in the repair of peroxidized cell membranes following oxidative stress. Free Radic Biol Med 87:356\u2013365. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2015.06.009","journal-title":"Free Radic Biol Med"},{"issue":"7621","key":"2427_CR27","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/nature19356","volume":"537","author":"ME Dickinson","year":"2016","unstructured":"Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ et al (2016) High-throughput discovery of novel developmental phenotypes. Nature 537(7621):508\u2013514. https:\/\/doi.org\/10.1038\/nature19356","journal-title":"Nature"},{"key":"2427_CR28","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuint.2015.08.006","volume":"90","author":"AA Asuni","year":"2015","unstructured":"Asuni AA, Guridi M, Sanchez S, Sadowski MJ (2015) Antioxidant peroxiredoxin 6 protein rescues toxicity due to oxidative stress and cellular hypoxia in vitro, and attenuates prion-related pathology in vivo. Neurochem Int 90:152\u2013165. https:\/\/doi.org\/10.1016\/j.neuint.2015.08.006","journal-title":"Neurochem Int"},{"issue":"1","key":"2427_CR29","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s13041-021-00754-1","volume":"14","author":"S Phasuk","year":"2021","unstructured":"Phasuk S, Pairojana T, Suresh P, Yang CH, Roytrakul S, Huang SP, Chen CC, Pakaprot N et al (2021) Enhanced contextual fear memory in peroxiredoxin 6 knockout mice is associated with hyperactivation of MAPK signaling pathway. Mol Brain 14(1):42. https:\/\/doi.org\/10.1186\/s13041-021-00754-1","journal-title":"Mol Brain"},{"issue":"7","key":"2427_CR30","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1038\/sj.cdd.4401597","volume":"12","author":"N Fatma","year":"2005","unstructured":"Fatma N, Kubo E, Sharma P, Beier DR, Singh DP (2005) Impaired homeostasis and phenotypic abnormalities in Prdx6\u2212\/\u2212 mice lens epithelial cells by reactive oxygen species: increased expression and activation of TGFbeta. Cell Death Differ 12(7):734\u2013750. https:\/\/doi.org\/10.1038\/sj.cdd.4401597","journal-title":"Cell Death Differ"},{"issue":"2","key":"2427_CR31","doi-asserted-by":"publisher","first-page":"C342","DOI":"10.1152\/ajpcell.00336.2009","volume":"298","author":"E Kubo","year":"2010","unstructured":"Kubo E, Hasanova N, Tanaka Y, Fatma N, Takamura Y, Singh DP, Akagi Y (2010) Protein expression profiling of lens epithelial cells from Prdx6-depleted mice and their vulnerability to UV radiation exposure. Am J Physiol Cell Physiol 298(2):C342\u2013C354. https:\/\/doi.org\/10.1152\/ajpcell.00336.2009","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"2427_CR32","doi-asserted-by":"publisher","first-page":"C954","DOI":"10.1152\/ajpcell.00061.2011","volume":"301","author":"N Fatma","year":"2011","unstructured":"Fatma N, Singh P, Chhunchha B, Kubo E, Shinohara T, Bhargavan B, Singh DP (2011) Deficiency of Prdx6 in lens epithelial cells induces ER stress response-mediated impaired homeostasis and apoptosis. Am J Physiol Cell Physiol 301(4):C954\u2013C967. https:\/\/doi.org\/10.1152\/ajpcell.00061.2011","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1","key":"2427_CR33","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.atherosclerosis.2004.06.007","volume":"177","author":"X Wang","year":"2004","unstructured":"Wang X, Phelan SA, Petros C, Taylor EF, Ledinski G, Jurgens G, Forsman-Semb K, Paigen B (2004) Peroxiredoxin 6 deficiency and atherosclerosis susceptibility in mice: significance of genetic background for assessing atherosclerosis. Atherosclerosis 177(1):61\u201370. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2004.06.007","journal-title":"Atherosclerosis"},{"issue":"10","key":"2427_CR34","doi-asserted-by":"publisher","first-page":"3210","DOI":"10.2337\/db14-0144","volume":"63","author":"F Pacifici","year":"2014","unstructured":"Pacifici F, Arriga R, Sorice GP, Capuani B, Scioli MG, Pastore D, Donadel G, Bellia A et al (2014) Peroxiredoxin 6, a novel player in the pathogenesis of diabetes. Diabetes 63(10):3210\u20133220. https:\/\/doi.org\/10.2337\/db14-0144","journal-title":"Diabetes"},{"key":"2427_CR35","doi-asserted-by":"publisher","first-page":"9685607","DOI":"10.1155\/2019\/9685607","volume":"2019","author":"R Arriga","year":"2019","unstructured":"Arriga R, Pacifici F, Capuani B, Coppola A, Orlandi A, Scioli MG, Pastore D, Andreadi A et al (2019) Peroxiredoxin 6 is a key antioxidant enzyme in modulating the link between glycemic and lipogenic metabolism. Oxid Med Cell Longev 2019:9685607. https:\/\/doi.org\/10.1155\/2019\/9685607","journal-title":"Oxid Med Cell Longev"},{"issue":"7","key":"2427_CR36","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1093\/ecco-jcc\/jjx016","volume":"11","author":"H Melhem","year":"2017","unstructured":"Melhem H, Spalinger MR, Cosin-Roger J, Atrott K, Lang S, Wojtal KA, Vavricka SR, Rogler G et al (2017) Prdx6 deficiency ameliorates DSS colitis: relevance of compensatory antioxidant mechanisms. J Crohns Colitis 11(7):871\u2013884. https:\/\/doi.org\/10.1093\/ecco-jcc\/jjx016","journal-title":"J Crohns Colitis"},{"key":"2427_CR37","doi-asserted-by":"publisher","unstructured":"Pacifici F, Della-Morte D, Piermarini F, Arriga R, Scioli MG, Capuani B, Pastore D, Coppola A et al (2020) Prdx6 plays a main role in the crosstalk between aging and metabolic sarcopenia. Antioxidants (Basel) 9(4):329.\u00a0https:\/\/doi.org\/10.3390\/antiox9040329","DOI":"10.3390\/antiox9040329"},{"issue":"4","key":"2427_CR38","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1083\/jcb.200706090","volume":"179","author":"A Kumin","year":"2007","unstructured":"Kumin A, Schafer M, Epp N, Bugnon P, Born-Berclaz C, Oxenius A, Klippel A, Bloch W et al (2007) Peroxiredoxin 6 is required for blood vessel integrity in wounded skin. J Cell Biol 179(4):747\u2013760. https:\/\/doi.org\/10.1083\/jcb.200706090","journal-title":"J Cell Biol"},{"issue":"11","key":"2427_CR39","doi-asserted-by":"publisher","first-page":"3460","DOI":"10.1158\/0008-5472.CAN-12-4369","volume":"73","author":"F Rolfs","year":"2013","unstructured":"Rolfs F, Huber M, Gruber F, Bohm F, Pfister HJ, Bochkov VN, Tschachler E, Dummer R et al (2013) Dual role of the antioxidant enzyme peroxiredoxin 6 in skin carcinogenesis. Cancer Res 73(11):3460\u20133469. https:\/\/doi.org\/10.1158\/0008-5472.CAN-12-4369","journal-title":"Cancer Res"},{"issue":"6","key":"2427_CR40","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1194\/jlr.M400499-JLR200","volume":"46","author":"AB Fisher","year":"2005","unstructured":"Fisher AB, Dodia C, Feinstein SI, Ho YS (2005) Altered lung phospholipid metabolism in mice with targeted deletion of lysosomal-type phospholipase A2. J Lipid Res 46(6):1248\u20131256. https:\/\/doi.org\/10.1194\/jlr.M400499-JLR200","journal-title":"J Lipid Res"},{"issue":"4","key":"2427_CR41","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1002\/jcb.21703","volume":"104","author":"Y Wang","year":"2008","unstructured":"Wang Y, Feinstein SI, Fisher AB (2008) Peroxiredoxin 6 as an antioxidant enzyme: protection of lung alveolar epithelial type II cells from H2O2-induced oxidative stress. J Cell Biochem 104(4):1274\u20131285. https:\/\/doi.org\/10.1002\/jcb.21703","journal-title":"J Cell Biochem"},{"issue":"1\u20132","key":"2427_CR42","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1089\/ars.2006.8.229","volume":"8","author":"Y Wang","year":"2006","unstructured":"Wang Y, Feinstein SI, Manevich Y, Ho YS, Fisher AB (2006) Peroxiredoxin 6 gene-targeted mice show increased lung injury with paraquat-induced oxidative stress. Antioxid Redox Signal 8(1\u20132):229\u2013237. https:\/\/doi.org\/10.1089\/ars.2006.8.229","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"2427_CR43","doi-asserted-by":"publisher","first-page":"756","DOI":"10.1097\/CCM.0b013e318206befd","volume":"39","author":"D Yang","year":"2011","unstructured":"Yang D, Song Y, Wang X, Sun J, Ben Y, An X, Tong L, Bi J et al (2011) Deletion of peroxiredoxin 6 potentiates lipopolysaccharide-induced acute lung injury in mice. Crit Care Med 39(4):756\u2013764. https:\/\/doi.org\/10.1097\/CCM.0b013e318206befd","journal-title":"Crit Care Med"},{"issue":"8","key":"2427_CR44","doi-asserted-by":"publisher","first-page":"451","DOI":"10.3109\/01902141003754128","volume":"36","author":"IK Sundar","year":"2010","unstructured":"Sundar IK, Chung S, Hwang JW, Arunachalam G, Cook S, Yao H, Mazur W, Kinnula VL et al (2010) Peroxiredoxin 6 differentially regulates acute and chronic cigarette smoke-mediated lung inflammatory response and injury. Exp Lung Res 36(8):451\u2013462. https:\/\/doi.org\/10.3109\/01902141003754128","journal-title":"Exp Lung Res"},{"key":"2427_CR45","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.intimp.2018.12.053","volume":"68","author":"X Wang","year":"2019","unstructured":"Wang X, An X, Wang X, Hu X, Bi J, Tong L, Yang D, Song Y et al (2019) Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury. Int Immunopharmacol 68:252\u2013258. https:\/\/doi.org\/10.1016\/j.intimp.2018.12.053","journal-title":"Int Immunopharmacol"},{"issue":"8","key":"2427_CR46","doi-asserted-by":"publisher","first-page":"2885","DOI":"10.1096\/fj.201500146R","volume":"30","author":"JP Vazquez-Medina","year":"2016","unstructured":"Vazquez-Medina JP, Dodia C, Weng L, Mesaros C, Blair IA, Feinstein SI, Chatterjee S, Fisher AB (2016) The phospholipase A2 activity of peroxiredoxin 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonary endothelium and alveolar macrophages. Faseb J 30(8):2885\u20132898. https:\/\/doi.org\/10.1096\/fj.201500146R","journal-title":"Faseb J"},{"issue":"2","key":"2427_CR47","doi-asserted-by":"publisher","first-page":"G266","DOI":"10.1152\/ajpgi.90583.2008","volume":"296","author":"T Eismann","year":"2009","unstructured":"Eismann T, Huber N, Shin T, Kuboki S, Galloway E, Wyder M, Edwards MJ, Greis KD et al (2009) Peroxiredoxin-6 protects against mitochondrial dysfunction and liver injury during ischemia-reperfusion in mice. Am J Physiol Gastrointest Liver Physiol 296(2):G266\u2013G274. https:\/\/doi.org\/10.1152\/ajpgi.90583.2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"2427_CR48","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1038\/ki.2015.277","volume":"89","author":"SL Sorrell","year":"2016","unstructured":"Sorrell SL, Golder ZJ, Johnstone DB, Frankl F (2016) Renal peroxiredoxin 6 interacts with anion exchanger 1 and plays a novel role in pH homeostasis. Kidney Int 89(1):105\u2013112. https:\/\/doi.org\/10.1038\/ki.2015.277","journal-title":"Kidney Int"},{"key":"2427_CR49","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.redox.2015.02.004","volume":"5","author":"B Ozkosem","year":"2015","unstructured":"Ozkosem B, Feinstein SI, Fisher AB, O\u2019Flaherty C (2015) Advancing age increases sperm chromatin damage and impairs fertility in peroxiredoxin 6 null mice. Redox Biol 5:15\u201323. https:\/\/doi.org\/10.1016\/j.redox.2015.02.004","journal-title":"Redox Biol"},{"issue":"1","key":"2427_CR50","doi-asserted-by":"publisher","first-page":"12994","DOI":"10.1038\/s41598-017-13411-2","volume":"7","author":"AR Moawad","year":"2017","unstructured":"Moawad AR, Fernandez MC, Scarlata E, Dodia C, Feinstein SI, Fisher AB, O\u2019Flaherty C (2017) Deficiency of peroxiredoxin 6 or inhibition of its phospholipase A2 activity impair the in vitro sperm fertilizing competence in mice. Sci Rep 7(1):12994. https:\/\/doi.org\/10.1038\/s41598-017-13411-2","journal-title":"Sci Rep"},{"issue":"4","key":"2427_CR51","doi-asserted-by":"publisher","first-page":"L656","DOI":"10.1152\/ajplung.00344.2018","volume":"316","author":"JP Vazquez-Medina","year":"2019","unstructured":"Vazquez-Medina JP, Tao JQ, Patel P, Bannitz-Fernandes R, Dodia C, Sorokina EM, Feinstein SI, Chatterjee S et al (2019) Genetic inactivation of the phospholipase A2 activity of peroxiredoxin 6 in mice protects against LPS-induced acute lung injury. Am J Physiol Lung Cell Mol Physiol 316(4):L656\u2013L668. https:\/\/doi.org\/10.1152\/ajplung.00344.2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"2427_CR52","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s12035-014-8885-4","volume":"52","author":"H Yun","year":"2015","unstructured":"Yun H, Choi DY, Oh KW, Hong JT (2015) PRDX6 exacerbates dopaminergic neurodegeneration in a MPTP mouse model of Parkinson\u2019s disease. Mol Neurobiol 52(1):422\u2013431. https:\/\/doi.org\/10.1007\/s12035-014-8885-4","journal-title":"Mol Neurobiol"},{"issue":"4","key":"2427_CR53","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1165\/rcmb.2005-0333oc","volume":"34","author":"Y Wang","year":"2006","unstructured":"Wang Y, Phelan SA, Manevich Y, Feinstein SI, Fisher AB (2006) Transgenic mice overexpressing peroxiredoxin 6 show increased resistance to lung injury in hyperoxia. Am J Respir Cell Mol Biol 34(4):481\u2013486. https:\/\/doi.org\/10.1165\/rcmb.2005-0333oc","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"2427_CR54","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.2353\/ajpath.2006.060119","volume":"169","author":"A Kumin","year":"2006","unstructured":"Kumin A, Huber C, Rulicke T, Wolf E, Werner S (2006) Peroxiredoxin 6 is a potent cytoprotective enzyme in the epidermis. Am J Pathol 169(4):1194\u20131205. https:\/\/doi.org\/10.2353\/ajpath.2006.060119","journal-title":"Am J Pathol"},{"issue":"6","key":"2427_CR55","doi-asserted-by":"publisher","first-page":"7748","DOI":"10.1096\/fj.201802718R","volume":"33","author":"J Zhang","year":"2019","unstructured":"Zhang J, Lin Y, Dai X, Fang W, Wu X, Chen X (2019) Metformin treatment improves the spatial memory of aged mice in an APOE genotype-dependent manner. Faseb J 33(6):7748\u20137757. https:\/\/doi.org\/10.1096\/fj.201802718R","journal-title":"Faseb J"},{"issue":"10043","key":"2427_CR56","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","volume":"388","author":"P Scheltens","year":"2016","unstructured":"Scheltens P, Blennow K, Breteler MM, de Strooper B, Frisoni GB, Salloway S, Van der Flier WM (2016) Alzheimer\u2019s disease. Lancet 388(10043):505\u2013517. https:\/\/doi.org\/10.1016\/S0140-6736(15)01124-1","journal-title":"Lancet"},{"key":"2427_CR57","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13024-015-0002-2","volume":"10","author":"DS Liu","year":"2015","unstructured":"Liu DS, Pan XD, Zhang J, Shen H, Collins NC, Cole AM, Koster KP, Ben AM et al (2015) APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener 10:7. https:\/\/doi.org\/10.1186\/s13024-015-0002-2","journal-title":"Mol Neurodegener"},{"issue":"1","key":"2427_CR58","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/s13024-018-0298-9","volume":"13","author":"M Gratuze","year":"2018","unstructured":"Gratuze M, Leyns C, Holtzman DM (2018) New insights into the role of TREM2 in Alzheimer\u2019s disease. Mol Neurodegener 13(1):66. https:\/\/doi.org\/10.1186\/s13024-018-0298-9","journal-title":"Mol Neurodegener"},{"issue":"4","key":"2427_CR59","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/j.cell.2020.06.038","volume":"182","author":"WT Chen","year":"2020","unstructured":"Chen WT, Lu A, Craessaerts K, Pavie B, Sala FC, Corthout N, Qian X, Lalakova J et al (2020) Spatial transcriptomics and in situ sequencing to study Alzheimer\u2019s disease. Cell 182(4):976\u2013991. https:\/\/doi.org\/10.1016\/j.cell.2020.06.038","journal-title":"Cell"},{"issue":"15","key":"2427_CR60","doi-asserted-by":"publisher","first-page":"3624","DOI":"10.7150\/thno.21408","volume":"7","author":"MH Park","year":"2017","unstructured":"Park MH, Yun HM, Hwang CJ, Park SI, Han SB, Hwang DY, Yoon DY, Kim S et al (2017) Presenilin mutation suppresses lung tumorigenesis via inhibition of peroxiredoxin 6 activity and expression. Theranostics 7(15):3624\u20133637. https:\/\/doi.org\/10.7150\/thno.21408","journal-title":"Theranostics"},{"issue":"6","key":"2427_CR61","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1007\/s00401-017-1691-0","volume":"133","author":"E Drummond","year":"2017","unstructured":"Drummond E, Nayak S, Faustin A, Pires G, Hickman RA, Askenazi M, Cohen M, Haldiman T et al (2017) Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer\u2019s disease. Acta Neuropathol 133(6):933\u2013954. https:\/\/doi.org\/10.1007\/s00401-017-1691-0","journal-title":"Acta Neuropathol"},{"issue":"1\u20132","key":"2427_CR62","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/s0006-8993(02)04243-9","volume":"967","author":"K Krapfenbauer","year":"2003","unstructured":"Krapfenbauer K, Engidawork E, Cairns N, Fountoulakis M, Lubec G (2003) Aberrant expression of peroxiredoxin subtypes in neurodegenerative disorders. Brain Res 967(1\u20132):152\u2013160. https:\/\/doi.org\/10.1016\/s0006-8993(02)04243-9","journal-title":"Brain Res"},{"issue":"3","key":"2427_CR63","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/j.neurobiolaging.2006.01.011","volume":"28","author":"D Sizova","year":"2007","unstructured":"Sizova D, Charbaut E, Delalande F, Poirier F, High AA, Parker F, Van Dorsselaer A, Duchesne M et al (2007) Proteomic analysis of brain tissue from an Alzheimer\u2019s disease mouse model by two-dimensional difference gel electrophoresis. Neurobiol Aging 28(3):357\u2013370. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2006.01.011","journal-title":"Neurobiol Aging"},{"key":"2427_CR64","doi-asserted-by":"publisher","unstructured":"Lamoureux L, Simon S, Waitt B, Knox JD (2018) Proteomic screen of brain glycoproteome reveals prion specific marker of pathogenesis. Proteomics 18(1).\u00a0https:\/\/doi.org\/10.1002\/pmic.201700296","DOI":"10.1002\/pmic.201700296"},{"issue":"4","key":"2427_CR65","doi-asserted-by":"publisher","first-page":"2409","DOI":"10.1007\/s12035-015-9208-0","volume":"53","author":"HM Yun","year":"2016","unstructured":"Yun HM, Jin P, Park KR, Hwang J, Jeong HS, Kim EC, Jung JK, Oh KW et al (2016) Thiacremonone potentiates anti-oxidant effects to improve memory dysfunction in an APP\/PS1 transgenic mice model. Mol Neurobiol 53(4):2409\u20132420. https:\/\/doi.org\/10.1007\/s12035-015-9208-0","journal-title":"Mol Neurobiol"},{"issue":"43","key":"2427_CR66","doi-asserted-by":"publisher","first-page":"11111","DOI":"10.1523\/JNEUROSCI.3505-06.2006","volume":"26","author":"D Zhu","year":"2006","unstructured":"Zhu D, Lai Y, Shelat PB, Hu C, Sun GY, Lee JC (2006) Phospholipases A2 mediate amyloid-beta peptide-induced mitochondrial dysfunction. J Neurosci 26(43):11111\u201311119. https:\/\/doi.org\/10.1523\/JNEUROSCI.3505-06.2006","journal-title":"J Neurosci"},{"issue":"2","key":"2427_CR67","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.freeradbiomed.2008.09.027","volume":"46","author":"I Chowdhury","year":"2009","unstructured":"Chowdhury I, Mo Y, Gao L, Kazi A, Fisher AB, Feinstein SI (2009) Oxidant stress stimulates expression of the human peroxiredoxin 6 gene by a transcriptional mechanism involving an antioxidant response element. Free Radic Biol Med 46(2):146\u2013153. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.09.027","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"2427_CR68","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s12640-017-9833-7","volume":"33","author":"T Hofer","year":"2018","unstructured":"Hofer T, Duale N, Muusse M, Eide DM, Dahl H, Boix F, Andersen JM, Olsen AK et al (2018) Restoration of cognitive performance in mice carrying a deficient allele of 8-oxoguanine DNA glycosylase by X-ray irradiation. Neurotox Res 33(4):824\u2013836. https:\/\/doi.org\/10.1007\/s12640-017-9833-7","journal-title":"Neurotox Res"},{"issue":"7","key":"2427_CR69","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1194\/jlr.R082578","volume":"59","author":"AB Fisher","year":"2018","unstructured":"Fisher AB (2018) The phospholipase A2 activity of peroxiredoxin 6. J Lipid Res 59(7):1132\u20131147. https:\/\/doi.org\/10.1194\/jlr.R082578","journal-title":"J Lipid Res"},{"key":"2427_CR70","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.brainres.2011.06.064","volume":"1410","author":"K Yata","year":"2011","unstructured":"Yata K, Oikawa S, Sasaki R, Shindo A, Yang R, Murata M, Kanamaru K, Tomimoto H (2011) Astrocytic neuroprotection through induction of cytoprotective molecules; a proteomic analysis of mutant P301S tau-transgenic mouse. Brain Res 1410:12\u201323. https:\/\/doi.org\/10.1016\/j.brainres.2011.06.064","journal-title":"Brain Res"},{"issue":"9","key":"2427_CR71","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1212\/01.wnl.0000125693.59817.31","volume":"62","author":"D Seripa","year":"2004","unstructured":"Seripa D, Matera MG, D\u2019Andrea RP, Gravina C, Masullo C, Daniele A, Bizzarro A, Rinaldi M et al (2004) Alzheimer disease risk associated with APOE4 is modified by STH gene polymorphism. Neurology 62(9):1631\u20131633. https:\/\/doi.org\/10.1212\/01.wnl.0000125693.59817.31","journal-title":"Neurology"},{"issue":"3","key":"2427_CR72","doi-asserted-by":"publisher","first-page":"e91508","DOI":"10.1371\/journal.pone.0091508","volume":"9","author":"M Jo","year":"2014","unstructured":"Jo M, Yun HM, Park KR, Park MH, Lee DH, Cho SH, Yoo HS, Lee YM et al (2014) Anti-cancer effect of thiacremonone through down regulation of peroxiredoxin 6. PLoS ONE 9(3):e91508. https:\/\/doi.org\/10.1371\/journal.pone.0091508","journal-title":"PLoS ONE"},{"issue":"1","key":"2427_CR73","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/syn.20984","volume":"66","author":"SY Tsai","year":"2012","unstructured":"Tsai SY, Rothman RK, Su TP (2012) Insights into the Sigma-1 receptor chaperone\u2019s cellular functions: a microarray report. Synapse 66(1):42\u201351. https:\/\/doi.org\/10.1002\/syn.20984","journal-title":"Synapse"},{"issue":"Suppl 1","key":"2427_CR74","doi-asserted-by":"publisher","first-page":"S62","DOI":"10.1016\/S1353-8020(13)70017-8","volume":"20","author":"H Mccann","year":"2014","unstructured":"Mccann H, Stevens CH, Cartwright H, Halliday GM (2014) alpha-Synucleinopathy phenotypes. Parkinsonism Relat Disord 20(Suppl 1):S62\u2013S67. https:\/\/doi.org\/10.1016\/S1353-8020(13)70017-8","journal-title":"Parkinsonism Relat Disord"},{"issue":"18","key":"2427_CR75","doi-asserted-by":"publisher","first-page":"18614","DOI":"10.1074\/jbc.M401135200","volume":"279","author":"JJ Palacino","year":"2004","unstructured":"Palacino JJ, Sagi D, Goldberg MS, Krauss S, Motz C, Wacker M, Klose J, Shen J (2004) Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem 279(18):18614\u201318622. https:\/\/doi.org\/10.1074\/jbc.M401135200","journal-title":"J Biol Chem"},{"key":"2427_CR76","doi-asserted-by":"publisher","first-page":"1930","DOI":"10.1016\/j.bbadis.2013.07.002","volume":"12","author":"J Elkharaz","year":"1832","unstructured":"Elkharaz J, Ugun-Klusek A, Constantin-Teodosiu D, Lawler K, Mayer RJ, Billett E, Lowe J (1832) Bedford L (2013) Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones. Biochim Biophys Acta 12:1930\u20131938. https:\/\/doi.org\/10.1016\/j.bbadis.2013.07.002","journal-title":"Biochim Biophys Acta"},{"issue":"18","key":"2427_CR77","doi-asserted-by":"publisher","first-page":"4284","DOI":"10.1002\/pmic.200900126","volume":"9","author":"EJ Davison","year":"2009","unstructured":"Davison EJ, Pennington K, Hung CC, Peng J, Rafiq R, Ostareck-Lederer A, Ostareck DH, Ardley HC et al (2009) Proteomic analysis of increased Parkin expression and its interactants provides evidence for a role in modulation of mitochondrial function. Proteomics 9(18):4284\u20134297. https:\/\/doi.org\/10.1002\/pmic.200900126","journal-title":"Proteomics"},{"issue":"2","key":"2427_CR78","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1194\/jlr.R300016-JLR200","volume":"45","author":"GY Sun","year":"2004","unstructured":"Sun GY, Xu J, Jensen MD, Simonyi A (2004) Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases. J Lipid Res 45(2):205\u2013213. https:\/\/doi.org\/10.1194\/jlr.R300016-JLR200","journal-title":"J Lipid Res"},{"issue":"3","key":"2427_CR79","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1177\/1073858405285923","volume":"12","author":"AA Farooqui","year":"2006","unstructured":"Farooqui AA, Horrocks LA (2006) Phospholipase A2-generated lipid mediators in the brain: the good, the bad, and the ugly. Neuroscientist 12(3):245\u2013260. https:\/\/doi.org\/10.1177\/1073858405285923","journal-title":"Neuroscientist"},{"issue":"1","key":"2427_CR80","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/s0361-9230(00)00427-5","volume":"54","author":"M Tariq","year":"2001","unstructured":"Tariq M, Khan HA, Al MK, Al DS (2001) Protective effect of quinacrine on striatal dopamine levels in 6-OHDA and MPTP models of Parkinsonism in rodents. Brain Res Bull 54(1):77\u201382. https:\/\/doi.org\/10.1016\/s0361-9230(00)00427-5","journal-title":"Brain Res Bull"},{"key":"2427_CR81","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/B978-0-12-802395-2.00025-0","volume":"145","author":"GG Kovacs","year":"2017","unstructured":"Kovacs GG (2017) Tauopathies. Handb Clin Neurol 145:355\u2013368. https:\/\/doi.org\/10.1016\/B978-0-12-802395-2.00025-0","journal-title":"Handb Clin Neurol"},{"issue":"47","key":"2427_CR82","doi-asserted-by":"publisher","first-page":"39268","DOI":"10.1074\/jbc.M506116200","volume":"280","author":"L Gao","year":"2005","unstructured":"Gao L, Tse SW, Conrad C, Andreadis A (2005) Saitohin, which is nested in the tau locus and confers allele-specific susceptibility to several neurodegenerative diseases, interacts with peroxiredoxin 6. J Biol Chem 280(47):39268\u201339272. https:\/\/doi.org\/10.1074\/jbc.M506116200","journal-title":"J Biol Chem"},{"issue":"1","key":"2427_CR83","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1080\/19336896.2020.1796898","volume":"14","author":"J Bettinger","year":"2020","unstructured":"Bettinger J, Ghaemmaghami S (2020) Methionine oxidation within the prion protein. Prion 14(1):193\u2013205. https:\/\/doi.org\/10.1080\/19336896.2020.1796898","journal-title":"Prion"},{"key":"2427_CR84","doi-asserted-by":"publisher","unstructured":"Zhang X, Zhao D, Wu W, Ali SS, Lai M, Yang D, Li J, Guan Z et al (2020) Melatonin regulates mitochondrial dynamics and alleviates neuron damage in prion diseases. Aging (Albany NY) 12(11):11139\u201311151. https:\/\/doi.org\/10.18632\/aging.103328","DOI":"10.18632\/aging.103328"},{"issue":"15","key":"2427_CR85","doi-asserted-by":"publisher","first-page":"2541","DOI":"10.1002\/1522-2683(200208)23:15<2541::AID-ELPS2541>3.0.CO;2-1","volume":"23","author":"K Krapfenbauer","year":"2002","unstructured":"Krapfenbauer K, Yoo BC, Fountoulakis M, Mitrova E, Lubec G (2002) Expression patterns of antioxidant proteins in brains of patients with sporadic Creutzfeldt-Jacob disease. Electrophoresis 23(15):2541\u20132547. https:\/\/doi.org\/10.1002\/1522-2683(200208)23:15%3c2541::AID-ELPS2541%3e3.0.CO;2-1","journal-title":"Electrophoresis"},{"issue":"1","key":"2427_CR86","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1186\/1478-811X-10-38","volume":"10","author":"W Wagner","year":"2012","unstructured":"Wagner W, Reuter A, Huller P, Lower J, Wessler S (2012) Peroxiredoxin 6 promotes upregulation of the prion protein (PrP) in neuronal cells of prion-infected mice. Cell Commun Signal 10(1):38. https:\/\/doi.org\/10.1186\/1478-811X-10-38","journal-title":"Cell Commun Signal"},{"issue":"1","key":"2427_CR87","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1128\/jvi.74.1.411-417.2000","volume":"74","author":"J Kopacek","year":"2000","unstructured":"Kopacek J, Sakaguchi S, Shigematsu K, Nishida N, Atarashi R, Nakaoke R, Moriuchi R, Niwa M et al (2000) Upregulation of the genes encoding lysosomal hydrolases, a perforin-like protein, and peroxidases in the brains of mice affected with an experimental prion disease. J Virol 74(1):411\u2013417. https:\/\/doi.org\/10.1128\/jvi.74.1.411-417.2000","journal-title":"J Virol"},{"key":"2427_CR88","doi-asserted-by":"publisher","unstructured":"Scialo C, De Cecco E, Manganotti P, Legname G (2019) Prion and prion-like protein strains: deciphering the molecular basis of heterogeneity in neurodegeneration. Viruses 11(3):261. https:\/\/doi.org\/10.3390\/v11030261","DOI":"10.3390\/v11030261"},{"issue":"6435","key":"2427_CR89","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1126\/science.aav9776","volume":"364","author":"S Maniatis","year":"2019","unstructured":"Maniatis S, Aijo T, Vickovic S, Braine C, Kang K, Mollbrink A, Fagegaltier D, Andrusivova Z et al (2019) Spatiotemporal dynamics of molecular pathology in amyotrophic lateral sclerosis. Science 364(6435):89\u201393. https:\/\/doi.org\/10.1126\/science.aav9776","journal-title":"Science"},{"issue":"5","key":"2427_CR90","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1016\/S0002-9440(10)63426-8","volume":"165","author":"CW Strey","year":"2004","unstructured":"Strey CW, Spellman D, Stieber A, Gonatas JO, Wang X, Lambris JD, Gonatas NK (2004) Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am J Pathol 165(5):1701\u20131718. https:\/\/doi.org\/10.1016\/S0002-9440(10)63426-8","journal-title":"Am J Pathol"},{"key":"2427_CR91","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.nbd.2017.03.010","volume":"103","author":"NA Guadagno","year":"2017","unstructured":"Guadagno NA, Moriconi C, Licursi V, D\u2019Acunto E, Nisi PS, Carucci N, De Jaco A, Cacci E et al (2017) Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB. Neurobiol Dis 103:32\u201344. https:\/\/doi.org\/10.1016\/j.nbd.2017.03.010","journal-title":"Neurobiol Dis"},{"issue":"18","key":"2427_CR92","doi-asserted-by":"publisher","first-page":"4021","DOI":"10.1093\/hmg\/ddw242","volume":"25","author":"I Sanchez","year":"2016","unstructured":"Sanchez I, Balague E, Matilla-Duenas A (2016) Ataxin-1 regulates the cerebellar bioenergetics proteome through the GSK3beta-mTOR pathway which is altered in Spinocerebellar ataxia type 1 (SCA1). Hum Mol Genet 25(18):4021\u20134040. https:\/\/doi.org\/10.1093\/hmg\/ddw242","journal-title":"Hum Mol Genet"},{"key":"2427_CR93","doi-asserted-by":"publisher","first-page":"198","DOI":"10.3389\/fnagi.2019.00198","volume":"11","author":"J Lubec","year":"2019","unstructured":"Lubec J, Smidak R, Malikovic J, Feyissa DD, Korz V, Hoger H, Lubec G (2019) Dentate gyrus peroxiredoxin 6 levels discriminate aged unimpaired from impaired rats in a spatial memory task. Front Aging Neurosci 11:198. https:\/\/doi.org\/10.3389\/fnagi.2019.00198","journal-title":"Front Aging Neurosci"},{"key":"2427_CR94","doi-asserted-by":"publisher","first-page":"5408452","DOI":"10.1155\/2020\/5408452","volume":"2020","author":"Y Li","year":"2020","unstructured":"Li Y, Yu H, Chen C, Li S, Zhang Z, Xu H, Zhu F, Liu J et al (2020) Proteomic profile of mouse brain aging contributions to mitochondrial dysfunction, DNA oxidative damage, loss of neurotrophic factor, and synaptic and ribosomal proteins. Oxid Med Cell Longev 2020:5408452. https:\/\/doi.org\/10.1155\/2020\/5408452","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"2427_CR95","doi-asserted-by":"publisher","first-page":"C1","DOI":"10.1152\/ajpcell.00229.2015","volume":"310","author":"SP Singh","year":"2016","unstructured":"Singh SP, Chhunchha B, Fatma N, Kubo E, Singh SP, Singh DP (2016) Delivery of a protein transduction domain-mediated Prdx6 protein ameliorates oxidative stress-induced injury in human and mouse neuronal cells. Am J Physiol Cell Physiol 310(1):C1\u2013C16. https:\/\/doi.org\/10.1152\/ajpcell.00229.2015","journal-title":"Am J Physiol Cell Physiol"},{"issue":"2","key":"2427_CR96","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/j.neuron.2010.07.002","volume":"67","author":"MA Moskowitz","year":"2010","unstructured":"Moskowitz MA, Lo EH, Iadecola C (2010) The science of stroke: mechanisms in search of treatments. Neuron 67(2):181\u2013198. https:\/\/doi.org\/10.1016\/j.neuron.2010.07.002","journal-title":"Neuron"},{"issue":"1","key":"2427_CR97","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1007\/s12031-018-1064-8","volume":"65","author":"AA Sidyakin","year":"2018","unstructured":"Sidyakin AA, Kaysheva AL, Kopylov AT, Lobanov AV, Morozov SG (2018) Proteomic analysis of cerebral cortex extracts from Sus scrofa with induced hemorrhagic stroke. J Mol Neurosci 65(1):28\u201334. https:\/\/doi.org\/10.1007\/s12031-018-1064-8","journal-title":"J Mol Neurosci"},{"issue":"9","key":"2427_CR98","doi-asserted-by":"publisher","first-page":"1186","DOI":"10.2174\/1566524014666141021143333","volume":"14","author":"J Pan","year":"2014","unstructured":"Pan J, Liu H, Zhou J, Liu Z, Yang Y, Peng Y, You H, Yang D et al (2014) Ipsilateral hippocampal proteomics reveals mitochondrial antioxidative stress impairment in cortical-lesioned chronic mild stressed rats. Curr Mol Med 14(9):1186\u20131196. https:\/\/doi.org\/10.2174\/1566524014666141021143333","journal-title":"Curr Mol Med"},{"key":"2427_CR99","doi-asserted-by":"publisher","first-page":"6597401","DOI":"10.1155\/2017\/6597401","volume":"2017","author":"G Jia","year":"2017","unstructured":"Jia G, Tan B, Ma J, Zhang L, Jin X, Li C (2017) Prdx6 upregulation by curcumin attenuates ischemic oxidative damage via SP1 in rats after stroke. Biomed Res Int 2017:6597401. https:\/\/doi.org\/10.1155\/2017\/6597401","journal-title":"Biomed Res Int"},{"issue":"7","key":"2427_CR100","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s11064-013-1052-x","volume":"38","author":"S Yu","year":"2013","unstructured":"Yu S, Zhao J, Wang X, Lei S, Wu X, Chen Y, Wu J, Zhao Y (2013) 4-Hydroxybenzyl alcohol confers neuroprotection through up-regulation of antioxidant protein expression. Neurochem Res 38(7):1501\u20131516. https:\/\/doi.org\/10.1007\/s11064-013-1052-x","journal-title":"Neurochem Res"},{"issue":"3","key":"2427_CR101","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1600-079X.2008.00661.x","volume":"46","author":"JH Sung","year":"2009","unstructured":"Sung JH, Cho EH, Kim MO, Koh PO (2009) Identification of proteins differentially expressed by melatonin treatment in cerebral ischemic injury\u2013a proteomics approach. J Pineal Res 46(3):300\u2013306. https:\/\/doi.org\/10.1111\/j.1600-079X.2008.00661.x","journal-title":"J Pineal Res"},{"key":"2427_CR102","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.nlm.2013.01.002","volume":"101","author":"X Zhang","year":"2013","unstructured":"Zhang X, Yeung PK, Mcalonan GM, Chung SS, Chung SK (2013) Transgenic mice over-expressing endothelial endothelin-1 show cognitive deficit with blood-brain barrier breakdown after transient ischemia with long-term reperfusion. Neurobiol Learn Mem 101:46\u201354. https:\/\/doi.org\/10.1016\/j.nlm.2013.01.002","journal-title":"Neurobiol Learn Mem"},{"issue":"6","key":"2427_CR103","doi-asserted-by":"publisher","first-page":"544","DOI":"10.3340\/jkns.2016.59.6.544","volume":"59","author":"TM Choi","year":"2016","unstructured":"Choi TM, Yun M, Lee JK, Park JT, Park MS, Kim HS (2016) Proteomic analysis of a rat cerebral ischemic injury model after human cerebral endothelial cell transplantation. J Korean Neurosurg Soc 59(6):544\u2013550. https:\/\/doi.org\/10.3340\/jkns.2016.59.6.544","journal-title":"J Korean Neurosurg Soc"},{"issue":"7","key":"2427_CR104","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1038\/nrneurol.2010.74","volume":"6","author":"D Shlosberg","year":"2010","unstructured":"Shlosberg D, Benifla M, Kaufer D, Friedman A (2010) Blood-brain barrier breakdown as a therapeutic target in traumatic brain injury. Nat Rev Neurol 6(7):393\u2013403. https:\/\/doi.org\/10.1038\/nrneurol.2010.74","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"2427_CR105","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1080\/02699052.2018.1432892","volume":"32","author":"AP Di Battista","year":"2018","unstructured":"Di Battista AP, Rhind SG, Baker AJ, Jetly R, Debad JD, Richards D, Hutchison MG (2018) An investigation of neuroinjury biomarkers after sport-related concussion: from the subacute phase to clinical recovery. Brain Inj 32(5):575\u2013582. https:\/\/doi.org\/10.1080\/02699052.2018.1432892","journal-title":"Brain Inj"},{"key":"2427_CR106","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jneuroim.2018.03.002","volume":"319","author":"AP Di Battista","year":"2018","unstructured":"Di Battista AP, Churchill N, Schweizer TA, Rhind SG, Richards D, Baker AJ, Hutchison MG (2018) Blood biomarkers are associated with brain function and blood flow following sport concussion. J Neuroimmunol 319:1\u20138. https:\/\/doi.org\/10.1016\/j.jneuroim.2018.03.002","journal-title":"J Neuroimmunol"},{"key":"2427_CR107","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.freeradbiomed.2014.04.002","volume":"72","author":"Y Manevich","year":"2014","unstructured":"Manevich Y, Hutchens S, Halushka PV, Tew KD, Townsend DM, Jauch EC, Borg K (2014) Peroxiredoxin VI oxidation in cerebrospinal fluid correlates with traumatic brain injury outcome. Free Radic Biol Med 72:210\u2013221. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2014.04.002","journal-title":"Free Radic Biol Med"},{"key":"2427_CR108","doi-asserted-by":"publisher","first-page":"68","DOI":"10.3389\/fneur.2015.00068","volume":"6","author":"JE Buonora","year":"2015","unstructured":"Buonora JE, Yarnell AM, Lazarus RC, Mousseau M, Latour LL, Rizoli SB, Baker AJ, Rhind SG et al (2015) Multivariate analysis of traumatic brain injury: development of an assessment score. Front Neurol 6:68. https:\/\/doi.org\/10.3389\/fneur.2015.00068","journal-title":"Front Neurol"},{"key":"2427_CR109","doi-asserted-by":"publisher","first-page":"110","DOI":"10.3389\/fneur.2015.00110","volume":"6","author":"AP Di Battista","year":"2015","unstructured":"Di Battista AP, Buonora JE, Rhind SG, Hutchison MG, Baker AJ, Rizoli SB, Diaz-Arrastia R, Mueller GP (2015) Blood biomarkers in moderate-to-severe traumatic brain injury: potential utility of a multi-marker approach in characterizing outcome. Front Neurol 6:110. https:\/\/doi.org\/10.3389\/fneur.2015.00110","journal-title":"Front Neurol"},{"issue":"22","key":"2427_CR110","doi-asserted-by":"publisher","first-page":"1805","DOI":"10.1089\/neu.2014.3736","volume":"32","author":"JE Buonora","year":"2015","unstructured":"Buonora JE, Mousseau M, Jacobowitz DM, Lazarus RC, Yarnell AM, Olsen CH, Pollard HB, Diaz-Arrastia R et al (2015) Autoimmune profiling reveals peroxiredoxin 6 as a candidate traumatic brain injury biomarker. J Neurotrauma 32(22):1805\u20131814. https:\/\/doi.org\/10.1089\/neu.2014.3736","journal-title":"J Neurotrauma"},{"key":"2427_CR111","doi-asserted-by":"publisher","first-page":"8486","DOI":"10.1038\/srep08486","volume":"5","author":"X Zhang","year":"2015","unstructured":"Zhang X, Shi LL, Gao X, Jiang D, Zhong ZQ, Zeng X, Rao Y, Hu X et al (2015) Lentivirus-mediated inhibition of tumour necrosis factor-alpha improves motor function associated with PRDX6 in spinal cord contusion rats. Sci Rep 5:8486. https:\/\/doi.org\/10.1038\/srep08486","journal-title":"Sci Rep"},{"issue":"3","key":"2427_CR112","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1021\/pr0498180","volume":"4","author":"F Odreman","year":"2005","unstructured":"Odreman F, Vindigni M, Gonzales ML, Niccolini B, Candiano G, Zanotti B, Skrap M, Pizzolitto S et al (2005) Proteomic studies on low- and high-grade human brain astrocytomas. J Proteome Res 4(3):698\u2013708. https:\/\/doi.org\/10.1021\/pr0498180","journal-title":"J Proteome Res"},{"issue":"2","key":"2427_CR113","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s00432-007-0282-1","volume":"134","author":"CK Park","year":"2008","unstructured":"Park CK, Kim JH, Moon MJ, Jung JH, Lim SY, Park SH, Kim JH, Kim DG et al (2008) Investigation of molecular factors associated with malignant transformation of oligodendroglioma by proteomic study of a single case of rapid tumor progression. J Cancer Res Clin Oncol 134(2):255\u2013262. https:\/\/doi.org\/10.1007\/s00432-007-0282-1","journal-title":"J Cancer Res Clin Oncol"},{"issue":"9","key":"2427_CR114","first-page":"1255","volume":"32","author":"J Zhou","year":"2012","unstructured":"Zhou J, Liu Q, Wang J, Guo X, Song L (2012) Expressions of peroxiredoxin 1, peroxiredoxin 6 and GFAP in human brain astrocytoma and their clinical significance. Nan Fang Yi Ke Da Xue Xue Bao 32(9):1255\u20131259","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"2427_CR115","doi-asserted-by":"publisher","unstructured":"Liao J, Zeng G, Fang W, Huang W, Dai X, Ye Q, Zhang J, Chen X (2020) Increased Notch2\/NF-kappaB signaling may mediate the depression susceptibility: evidence from chronic social defeat stress mice and WKY rats. Physiol Behav 228:113197.\u00a0https:\/\/doi.org\/10.1016\/j.physbeh.2020.113197","DOI":"10.1016\/j.physbeh.2020.113197"},{"issue":"12","key":"2427_CR116","doi-asserted-by":"publisher","first-page":"e50532","DOI":"10.1371\/journal.pone.0050532","volume":"7","author":"KA Kekesi","year":"2012","unstructured":"Kekesi KA, Juhasz G, Simor A, Gulyassy P, Szego EM, Hunyadi-Gulyas E, Darula Z, Medzihradszky KF et al (2012) Altered functional protein networks in the prefrontal cortex and amygdala of victims of suicide. PLoS ONE 7(12):e50532. https:\/\/doi.org\/10.1371\/journal.pone.0050532","journal-title":"PLoS ONE"},{"issue":"3","key":"2427_CR117","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.bbrc.2018.10.017","volume":"505","author":"W Li","year":"2018","unstructured":"Li W, Zhu Y, Liu X, Hou J, Fang J, Shen J, Ma X (2018) Phencynonate mediates antidepressant response by activating sirtuin 6-SOD2\/Prdx6 pathway. Biochem Biophys Res Commun 505(3):898\u2013904. https:\/\/doi.org\/10.1016\/j.bbrc.2018.10.017","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"2427_CR118","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3109\/10715762.2011.649749","volume":"46","author":"SY Shim","year":"2012","unstructured":"Shim SY, Kim HS, Kim EK, Choi JH (2012) Expression of peroxiredoxin 1, 2, and 6 in the rat brain during perinatal development and in response to dexamethasone. Free Radic Res 46(3):231\u2013239. https:\/\/doi.org\/10.3109\/10715762.2011.649749","journal-title":"Free Radic Res"},{"issue":"8","key":"2427_CR119","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1177\/0269881109102786","volume":"24","author":"PC Mchugh","year":"2010","unstructured":"Mchugh PC, Rogers GR, Glubb DM, Joyce PR, Kennedy MA (2010) Proteomic analysis of rat hippocampus exposed to the antidepressant paroxetine. J Psychopharmacol 24(8):1243\u20131251. https:\/\/doi.org\/10.1177\/0269881109102786","journal-title":"J Psychopharmacol"},{"issue":"12","key":"2427_CR120","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1177\/0269881112460110","volume":"26","author":"CF Bisgaard","year":"2012","unstructured":"Bisgaard CF, Bak S, Christensen T, Jensen ON, Enghild JJ, Wiborg O (2012) Vesicular signalling and immune modulation as hedonic fingerprints: proteomic profiling in the chronic mild stress depression model. J Psychopharmacol 26(12):1569\u20131583. https:\/\/doi.org\/10.1177\/0269881112460110","journal-title":"J Psychopharmacol"},{"issue":"45","key":"2427_CR121","doi-asserted-by":"publisher","first-page":"16884","DOI":"10.1074\/jbc.RA119.009592","volume":"294","author":"SS Schattauer","year":"2019","unstructured":"Schattauer SS, Bedini A, Summers F, Reilly-Treat A, Andrews MM, Land BB, Chavkin C (2019) Reactive oxygen species (ROS) generation is stimulated by kappa opioid receptor activation through phosphorylated c-Jun N-terminal kinase and inhibited by p38 mitogen-activated protein kinase (MAPK) activation. J Biol Chem 294(45):16884\u201316896. https:\/\/doi.org\/10.1074\/jbc.RA119.009592","journal-title":"J Biol Chem"},{"issue":"1","key":"2427_CR122","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.tox.2013.09.014","volume":"314","author":"M Vicente-Rodriguez","year":"2013","unstructured":"Vicente-Rodriguez M, Gramage E, Herradon G, Perez-Garcia C (2013) Phosphoproteomic analysis of the striatum from pleiotrophin knockout and midkine knockout mice treated with cocaine reveals regulation of oxidative stress-related proteins potentially underlying cocaine-induced neurotoxicity and neurodegeneration. Toxicology 314(1):166\u2013173. https:\/\/doi.org\/10.1016\/j.tox.2013.09.014","journal-title":"Toxicology"},{"key":"2427_CR123","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbr.2013.07.026","volume":"253","author":"E Gramage","year":"2013","unstructured":"Gramage E, Perez-Garcia C, Vicente-Rodriguez M, Bollen S, Rojo L, Herradon G (2013) Regulation of extinction of cocaine-induced place preference by midkine is related to a differential phosphorylation of peroxiredoxin 6 in dorsal striatum. Behav Brain Res 253:223\u2013231. https:\/\/doi.org\/10.1016\/j.bbr.2013.07.026","journal-title":"Behav Brain Res"},{"issue":"7","key":"2427_CR124","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1021\/acs.chemrestox.5b00130","volume":"28","author":"M Vicente-Rodriguez","year":"2015","unstructured":"Vicente-Rodriguez M, Herradon G, Ferrer-Alcon M, Uribarri M, Perez-Garcia C (2015) Chronic cocaine use causes changes in the striatal proteome depending on the endogenous expression of pleiotrophin. Chem Res Toxicol 28(7):1443\u20131454. https:\/\/doi.org\/10.1021\/acs.chemrestox.5b00130","journal-title":"Chem Res Toxicol"},{"issue":"10","key":"2427_CR125","doi-asserted-by":"publisher","first-page":"1849","DOI":"10.1111\/j.1530-0277.2008.00754.x","volume":"32","author":"T Flatscher-Bader","year":"2008","unstructured":"Flatscher-Bader T, Wilce PA (2008) Impact of alcohol abuse on protein expression of midkine and excitatory amino acid transporter 1 in the human prefrontal cortex. Alcohol Clin Exp Res 32(10):1849\u20131858. https:\/\/doi.org\/10.1111\/j.1530-0277.2008.00754.x","journal-title":"Alcohol Clin Exp Res"},{"issue":"1","key":"2427_CR126","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.tins.2011.06.007","volume":"35","author":"AL Mahan","year":"2012","unstructured":"Mahan AL, Ressler KJ (2012) Fear conditioning, synaptic plasticity and the amygdala: implications for posttraumatic stress disorder. Trends Neurosci 35(1):24\u201335. https:\/\/doi.org\/10.1016\/j.tins.2011.06.007","journal-title":"Trends Neurosci"},{"issue":"2","key":"2427_CR127","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/wps.20050","volume":"12","author":"DA Regier","year":"2013","unstructured":"Regier DA, Kuhl EA, Kupfer DJ (2013) The DSM-5: Classification and criteria changes. World Psychiatry 12(2):92\u201398. https:\/\/doi.org\/10.1002\/wps.20050","journal-title":"World Psychiatry"},{"issue":"12","key":"2427_CR128","doi-asserted-by":"publisher","first-page":"723","DOI":"10.1101\/lm.041806.116","volume":"23","author":"I Slouzkey","year":"2016","unstructured":"Slouzkey I, Maroun M (2016) PI3-kinase cascade has a differential role in acquisition and extinction of conditioned fear memory in juvenile and adult rats. Learn Mem 23(12):723\u2013731. https:\/\/doi.org\/10.1101\/lm.041806.116","journal-title":"Learn Mem"},{"issue":"6","key":"2427_CR129","doi-asserted-by":"publisher","first-page":"2465","DOI":"10.1523\/JNEUROSCI.0735-14.2015","volume":"35","author":"J Lopez","year":"2015","unstructured":"Lopez J, Gamache K, Schneider R, Nader K (2015) Memory retrieval requires ongoing protein synthesis and NMDA receptor activity-mediated AMPA receptor trafficking. J Neurosci 35(6):2465\u20132475. https:\/\/doi.org\/10.1523\/JNEUROSCI.0735-14.2015","journal-title":"J Neurosci"},{"key":"2427_CR130","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-244X-9-17","volume":"9","author":"D Martins-De-Souza","year":"2009","unstructured":"Martins-De-Souza D, Gattaz WF, Schmitt A, Novello JC, Marangoni S, Turck CW, Dias-Neto E (2009) Proteome analysis of schizophrenia patients Wernicke\u2019s area reveals an energy metabolism dysregulation. BMC Psychiatry 9:17. https:\/\/doi.org\/10.1186\/1471-244X-9-17","journal-title":"BMC Psychiatry"},{"issue":"4","key":"2427_CR131","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/sj.mp.4001235","volume":"8","author":"HG Hwu","year":"2003","unstructured":"Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF (2003) Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 8(4):445\u2013452. https:\/\/doi.org\/10.1038\/sj.mp.4001235","journal-title":"Mol Psychiatry"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02427-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02427-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02427-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T18:23:02Z","timestamp":1633371782000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02427-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,19]]},"references-count":131,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["2427"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02427-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,19]]},"assertion":[{"value":"25 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 May 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 May 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}