{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:47:16Z","timestamp":1784213236041,"version":"3.55.0"},"reference-count":103,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["DA046794"],"award-info":[{"award-number":["DA046794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["HD070888"],"award-info":[{"award-number":["HD070888"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"New York Research Foundation","award":["Q0942016"],"award-info":[{"award-number":["Q0942016"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12035-021-02466-y","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T13:02:47Z","timestamp":1625230967000},"page":"4856-4870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Fluoxetine Potentiates Oral Methylphenidate-Induced Gene Regulation in the Rat Striatum"],"prefix":"10.1007","volume":"58","author":[{"given":"Connor","family":"Moon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Marion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panayotis K.","family":"Thanos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-1312","authenticated-orcid":false,"given":"Heinz","family":"Steiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"2466_CR1","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuropharm.2004.06.021","volume":"47","author":"WAJ Carlezon","year":"2004","unstructured":"Carlezon WAJ, Konradi C (2004) Understanding the neurobiological consequences of early exposure to psychotropic drugs: linking behavior with molecules. Neuropharmacology 47:47\u201360","journal-title":"Neuropharmacology"},{"key":"2466_CR2","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1007\/s12264-011-1004-x","volume":"27","author":"N Carrey","year":"2011","unstructured":"Carrey N, Wilkinson M (2011) A review of psychostimulant-induced neuroadaptation in developing animals. Neurosci Bull 27:197\u2013214","journal-title":"Neurosci Bull"},{"key":"2466_CR3","doi-asserted-by":"publisher","first-page":"1722","DOI":"10.1016\/j.neubiorev.2011.02.011","volume":"35","author":"EM Marco","year":"2011","unstructured":"Marco EM, Adriani W, Ruocco LA, Canese R, Sadile AG, Laviola G (2011) Neurobehavioral adaptations to methylphenidate: the issue of early adolescent exposure. Neurosci Biobehav Rev 35:1722\u20131739","journal-title":"Neurosci Biobehav Rev"},{"key":"2466_CR4","first-page":"207","volume-title":"Fluoxetine: pharmacology, mechanisms of action and potential side effects","author":"V Van Waes","year":"2015","unstructured":"Van Waes V, Steiner H (2015) Fluoxetine and other SSRI antidepressants potentiate addiction-related gene regulation by psychostimulant medications. In: Pinna G (ed) Fluoxetine: pharmacology, mechanisms of action and potential side effects. Nova Science Publishers, Hauppauge, NY, pp 207\u2013225"},{"issue":"Suppl 1","key":"2466_CR5","doi-asserted-by":"publisher","first-page":"S82","DOI":"10.1038\/sj.bjp.0706428","volume":"147","author":"L Iversen","year":"2006","unstructured":"Iversen L (2006) Neurotransmitter transporters and their impact on the development of psychopharmacology. Br J Pharmacol 147(Suppl 1):S82-88","journal-title":"Br J Pharmacol"},{"key":"2466_CR6","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1177\/1087054707299597","volume":"10","author":"L Castle","year":"2007","unstructured":"Castle L, Aubert RE, Verbrugge RR, Khalid M, Epstein RS (2007) Trends in medication treatment for ADHD. J Atten Disord 10:335\u2013342","journal-title":"J Atten Disord"},{"key":"2466_CR7","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1177\/1087054707311654","volume":"12","author":"SH Kollins","year":"2008","unstructured":"Kollins SH (2008) ADHD, substance use disorders, and psychostimulant treatment: current literature and treatment guidelines. J Atten Disord 12:115\u2013125","journal-title":"J Atten Disord"},{"key":"2466_CR8","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1037\/a0024898","volume":"137","author":"JM Swanson","year":"2011","unstructured":"Swanson JM, Wigal TL, Volkow ND (2011) Contrast of medical and nonmedical use of stimulant drugs, basis for the distinction, and risk of addiction: comment on Smith and Farah (2011). Psychol Bull 137:742\u2013748","journal-title":"Psychol Bull"},{"key":"2466_CR9","unstructured":"DSMMD, Diagnostic and statistical manual of mental disorders, fourth Edition. 2000, Washington, DC: American Psychiatric Association."},{"key":"2466_CR10","unstructured":"SAMHSA (2015) Behavioral health trends in the United States: results from the 2014 national survey on drug use and health. NSDUH Series H-50, HHS Publication No (SMA) 15-4927 https:\/\/www.samhsa.gov\/data\/sites\/default\/files\/NSDUH-FRR1-2014\/NSDUH-FRR1-2014.pdf"},{"key":"2466_CR11","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1007\/s10567-014-0177-z","volume":"18","author":"K Benson","year":"2015","unstructured":"Benson K, Flory K, Humphreys KL, Lee SS (2015) Misuse of stimulant medication among college students: a comprehensive review and meta-analysis. Clin Child Fam Psychol Rev 18:50\u201376","journal-title":"Clin Child Fam Psychol Rev"},{"key":"2466_CR12","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1176\/appi.ajp.2018.17091048","volume":"175","author":"WM Compton","year":"2018","unstructured":"Compton WM, Han B, Blanco C, Johnson K, Jones CM (2018) Prevalence and correlates of prescription stimulant use, misuse, use disorders, and motivations for misuse among adults in the United States. Am J Psychiatry 175:741\u2013755","journal-title":"Am J Psychiatry"},{"key":"2466_CR13","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3200\/JACH.54.5.261-268","volume":"54","author":"BP White","year":"2006","unstructured":"White BP, Becker-Blease KA, Grace-Bishop K (2006) Stimulant medication use, misuse, and abuse in an undergraduate and graduate student sample. J Am Coll Health 54:261\u2013268","journal-title":"J Am Coll Health"},{"key":"2466_CR14","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1001\/archpedi.155.5.560","volume":"155","author":"JL Rushton","year":"2001","unstructured":"Rushton JL, Whitmire JT (2001) Pediatric stimulant and selective serotonin reuptake inhibitor prescription trends: 1992 to 1998. Arch Pediatr Adolesc Med 155:560\u2013565","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2466_CR15","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1176\/appi.ajp.160.3.438","volume":"160","author":"DJ Safer","year":"2003","unstructured":"Safer DJ, Zito JM, DosReis S (2003) Concomitant psychotropic medication for youths. Am J Psychiatry 160:438\u2013449","journal-title":"Am J Psychiatry"},{"key":"2466_CR16","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1097\/00008480-200310000-00006","volume":"15","author":"J Waxmonsky","year":"2003","unstructured":"Waxmonsky J (2003) Assessment and treatment of attention deficit hyperactivity disorder in children with comorbid psychiatric illness. Curr Opin Pediatr 15:476\u2013482","journal-title":"Curr Opin Pediatr"},{"issue":"Suppl 8","key":"2466_CR17","first-page":"27","volume":"67","author":"TJ Spencer","year":"2006","unstructured":"Spencer TJ (2006) ADHD and comorbidity in childhood. J Clin Psychiatry 67(Suppl 8):27\u201331","journal-title":"J Clin Psychiatry"},{"issue":"Suppl 22","key":"2466_CR18","first-page":"6","volume":"12","author":"JC Nelson","year":"2007","unstructured":"Nelson JC (2007) Augmentation strategies in the treatment of major depressive disorder. Recent findings and current status of augmentation strategies. CNS Spectr 12(Suppl 22):6\u20139","journal-title":"CNS Spectr"},{"key":"2466_CR19","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/j.1440-1819.2008.01767.x","volume":"62","author":"M Ishii","year":"2008","unstructured":"Ishii M, Tatsuzawa Y, Yoshino A, Nomura S (2008) Serotonin syndrome induced by augmentation of SSRI with methylphenidate. Psychiatry Clin Neurosci 62:246","journal-title":"Psychiatry Clin Neurosci"},{"key":"2466_CR20","doi-asserted-by":"publisher","first-page":"87","DOI":"10.4088\/JCP.v69n0112","volume":"69","author":"AV Ravindran","year":"2008","unstructured":"Ravindran AV, Kennedy SH, O\u2019Donovan MC, Fallu A, Camacho F, Binder CE (2008) Osmotic-release oral system methylphenidate augmentation of antidepressant monotherapy in major depressive disorder: results of a double-blind, randomized, placebo-controlled trial. J Clin Psychiatry 69:87\u201394","journal-title":"J Clin Psychiatry"},{"key":"2466_CR21","doi-asserted-by":"publisher","first-page":"1410","DOI":"10.4088\/JCP.v64n1202","volume":"64","author":"H Lavretsky","year":"2003","unstructured":"Lavretsky H, Kim MD, Kumar A, Reynolds CF (2003) Combined treatment with methylphenidate and citalopram for accelerated response in the elderly: an open trial. J Clin Psychiatry 64:1410\u20131414","journal-title":"J Clin Psychiatry"},{"key":"2466_CR22","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1743-6109.2007.00630.x","volume":"5","author":"A Csoka","year":"2008","unstructured":"Csoka A, Bahrick A, Mehtonen OP (2008) Persistent sexual dysfunction after discontinuation of selective serotonin reuptake inhibitors. J Sex Med 5:227\u2013233","journal-title":"J Sex Med"},{"key":"2466_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1002\/syn.10038","volume":"43","author":"ND Volkow","year":"2002","unstructured":"Volkow ND, Wang GJ, Fowler JS, Logan J, Franceschi D, Maynard L, Ding YS, Gatley SJ et al. (2002) Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: therapeutic implications. Synapse 43:181\u2013187","journal-title":"Synapse"},{"key":"2466_CR24","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1016\/j.tips.2007.10.004","volume":"28","author":"M Yano","year":"2007","unstructured":"Yano M, Steiner H (2007) Methylphenidate and cocaine: the same effects on gene regulation? Trends Pharmacol Sci 28:588\u2013596","journal-title":"Trends Pharmacol Sci"},{"key":"2466_CR25","first-page":"177","volume":"264","author":"D Pan","year":"1994","unstructured":"Pan D, Gatley SJ, Dewey SL, Chen R, Alexoff DA, Ding YS, Fowler JS (1994) Binding of bromine-substituted analogs of methylphenidate to monoamine transporters. Eur J Neurosci 264:177\u2013182","journal-title":"Eur J Neurosci"},{"key":"2466_CR26","doi-asserted-by":"publisher","first-page":"2032","DOI":"10.1046\/j.1471-4159.1997.68052032.x","volume":"68","author":"R Kuczenski","year":"1997","unstructured":"Kuczenski R, Segal DS (1997) Effects of methylphenidate on extracellular dopamine, serotonin, and norepinephrine: comparison with amphetamine. J Neurochem 68:2032\u20132037","journal-title":"J Neurochem"},{"key":"2466_CR27","first-page":"19","volume":"291","author":"DS Segal","year":"1999","unstructured":"Segal DS, Kuczenski R (1999) Escalating dose-binge treatment with methylphenidate: role of serotonin in the emergent behavioral profile. J Pharmacol Exp Ther 291:19\u201330","journal-title":"J Pharmacol Exp Ther"},{"key":"2466_CR28","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1471-2210-6-6","volume":"6","author":"DD Han","year":"2006","unstructured":"Han DD, Gu HH (2006) Comparison of the monoamine transporters from human and mouse in their sensitivities to psychostimulant drugs. BMC Pharmacol 6:6","journal-title":"BMC Pharmacol"},{"key":"2466_CR29","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1016\/j.neuroscience.2006.02.017","volume":"140","author":"M Yano","year":"2006","unstructured":"Yano M, Beverley JA, Steiner H (2006) Inhibition of methylphenidate-induced gene expression in the striatum by local blockade of D1 dopamine receptors: interhemispheric effects. Neuroscience 140:699\u2013709","journal-title":"Neuroscience"},{"key":"2466_CR30","doi-asserted-by":"publisher","first-page":"470","DOI":"10.1111\/j.1471-4159.2011.07215.x","volume":"117","author":"ME Alburges","year":"2011","unstructured":"Alburges ME, Hoonakker AJ, Horner KA, Fleckenstein AE, Hanson GR (2011) Methylphenidate alters basal ganglia neurotensin systems through dopaminergic mechanisms: a comparison with cocaine treatment. J Neurochem 117:470\u2013478","journal-title":"J Neurochem"},{"key":"2466_CR31","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pneurobio.2012.10.001","volume":"100","author":"H Steiner","year":"2013","unstructured":"Steiner H, Van Waes V (2013) Addiction-related gene regulation: risks of exposure to cognitive enhancers vs. other psychostimulants. Prog Neurobiol 100:60\u201380","journal-title":"Prog Neurobiol"},{"key":"2466_CR32","first-page":"496","volume":"267","author":"RV Bhat","year":"1993","unstructured":"Bhat RV, Baraban JM (1993) Activation of transcription factor genes in striatum by cocaine: role of both serotonin and dopamine systems. J Pharmacol Exp Ther 267:496\u2013505","journal-title":"J Pharmacol Exp Ther"},{"key":"2466_CR33","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1124\/mol.51.5.755","volume":"51","author":"JJ Lucas","year":"1997","unstructured":"Lucas JJ, Segu L, Hen R (1997) 5-Hydroxytryptamine1B receptors modulate the effect of cocaine on c-fos expression: converging evidence using 5-hydroxytryptamine1B knockout mice and the 5-hydroxytryptamine1B\/1D antagonist GR127935. Mol Pharmacol 51:755\u2013763","journal-title":"Mol Pharmacol"},{"key":"2466_CR34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0091-3057(00)00389-0","volume":"67","author":"N Castanon","year":"2000","unstructured":"Castanon N, Scearce-Levie K, Lucas JJ, Rocha B, Hen R (2000) Modulation of the effects of cocaine by 5-HT1B receptors: a comparison of knockouts and antagonists. Pharmacol Biochem Behav 67:559\u2013566","journal-title":"Pharmacol Biochem Behav"},{"key":"2466_CR35","first-page":"15","volume":"464","author":"BJ Morris","year":"1988","unstructured":"Morris BJ, Reimer S, Hollt V, Herz A (1988) Regulation of striatal prodynorphin mRNA levels by the raphe-striatal pathway. Brain Res 464:15\u201322","journal-title":"Brain Res"},{"key":"2466_CR36","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/0006-8993(96)00483-0","volume":"732","author":"PD Walker","year":"1996","unstructured":"Walker PD, Capodilupo JG, Wolf WA, Carlock LR (1996) Preprotachykinin and preproenkephalin mRNA expression within striatal subregions in response to altered serotonin transmission. Brain Res 732:25\u201335","journal-title":"Brain Res"},{"key":"2466_CR37","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neuroscience.2004.10.030","volume":"131","author":"KA Horner","year":"2005","unstructured":"Horner KA, Adams DH, Hanson GR, Keefe KA (2005) Blockade of stimulant-induced preprodynorphin mRNA expression in the striatal matrix by serotonin depletion. Neuroscience 131:67\u201377","journal-title":"Neuroscience"},{"key":"2466_CR38","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s002210050545","volume":"123","author":"H Steiner","year":"1998","unstructured":"Steiner H, Gerfen CR (1998) Role of dynorphin and enkephalin in the regulation of striatal output pathways and behavior. Exp Brain Res 123:60\u201376","journal-title":"Exp Brain Res"},{"key":"2466_CR39","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.neuropharm.2014.08.024","volume":"89","author":"V Van Waes","year":"2015","unstructured":"Van Waes V, Ehrlich S, Beverley JA, Steiner H (2015) Fluoxetine potentiation of methylphenidate-induced gene regulation in striatal output pathways: Potential role for 5-HT1B receptor. Neuropharmacology 89:77\u201386","journal-title":"Neuropharmacology"},{"key":"2466_CR40","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1177\/0269881117715598","volume":"31","author":"D Alter","year":"2017","unstructured":"Alter D, Beverley JA, Patel R, Bola\u00f1os-Guzm\u00e1n CA, Steiner H (2017) The 5-HT1B serotonin receptor regulates methylphenidate-induced gene expression in the striatum: Differential effects on immediate-early genes. J Psychopharmacol 31:1078\u20131087","journal-title":"J Psychopharmacol"},{"key":"2466_CR41","doi-asserted-by":"publisher","first-page":"736","DOI":"10.1007\/s12035-019-01739-x","volume":"57","author":"FE Padovan-Neto","year":"2020","unstructured":"Padovan-Neto FE, Patterson S, Voelkner NM, Altwal F, Beverley JA, West AR, Steiner H (2020) Selective regulation of 5-HT1B serotonin receptor expression in the striatum by dopamine depletion and repeated L-DOPA treatment: relationship to L-DOPA-induced dyskinesias. Mol Neurobiol 57:736\u2013751","journal-title":"Mol Neurobiol"},{"key":"2466_CR42","doi-asserted-by":"publisher","first-page":"6362","DOI":"10.1523\/JNEUROSCI.1205-04.2004","volume":"24","author":"AN Samaha","year":"2004","unstructured":"Samaha AN, Mallet N, Ferguson SM, Gonon F, Robinson TE (2004) The rate of cocaine administration alters gene regulation and behavioral plasticity: implications for addiction. J Neurosci 24:6362\u20136370","journal-title":"J Neurosci"},{"key":"2466_CR43","first-page":"126","volume":"51","author":"SP Barrett","year":"2005","unstructured":"Barrett SP, Darredeau C, Bordy LE, Pihl RO (2005) Characteristics of methylphenidate misuse in a university student sample. Can J Psychiatry 51:126\u2013127","journal-title":"Can J Psychiatry"},{"key":"2466_CR44","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1592\/phco.26.10.1501","volume":"26","author":"CJ Teter","year":"2006","unstructured":"Teter CJ, McCabe SE, LaGrange K, Cranford JA, Boyd CJ (2006) Illicit use of specific prescription stimulants among college students: prevalence, motives, and routes of administration. Pharmacotherapy 26:1501\u20131510","journal-title":"Pharmacotherapy"},{"key":"2466_CR45","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/j.neubiorev.2003.08.013","volume":"27","author":"JM Swanson","year":"2003","unstructured":"Swanson JM, Volkow ND (2003) Serum and brain concentrations of methylphenidate: implications for use and abuse. Neurosci Biobehav Rev 27:615\u2013621","journal-title":"Neurosci Biobehav Rev"},{"key":"2466_CR46","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.pbb.2015.01.005","volume":"131","author":"PK Thanos","year":"2015","unstructured":"Thanos PK, Robison LS, Steier J, Hwang YF, Cooper T, Swanson JM, Komatsu DE, Hadjiargyrou M et al (2015) A pharmacokinetic model of oral methylphenidate in the rat and effects on behavior. Pharmacol Biochem Behav 131:143\u2013153","journal-title":"Pharmacol Biochem Behav"},{"key":"2466_CR47","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00702-017-1680-4","volume":"124","author":"LS Robison","year":"2017","unstructured":"Robison LS, Ananth M, Hadjiargyrou M, Komatsu DE, Thanos PK (2017) Chronic oral methylphenidate treatment reversibly increases striatal dopamine transporter and dopamine type 1 receptor binding in rats. J Neural Transm 124:655\u2013667","journal-title":"J Neural Transm"},{"key":"2466_CR48","doi-asserted-by":"publisher","first-page":"53","DOI":"10.3389\/fnbeh.2017.00053","volume":"11","author":"LS Robison","year":"2017","unstructured":"Robison LS, Michaelos M, Gandhi J, Fricke D, Miao E, Lam CY, Mauceri A, Vitale M et al (2017) Sex differences in the physiological and behavioral effects of chronic oral methylphenidate treatment in rats. Front Behav Neurosci 11:53","journal-title":"Front Behav Neurosci"},{"key":"2466_CR49","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1046\/j.1460-9568.2003.02525.x","volume":"17","author":"I Willuhn","year":"2003","unstructured":"Willuhn I, Sun W, Steiner H (2003) Topography of cocaine-induced gene regulation in the rat striatum: relationship to cortical inputs and role of behavioural context. Eur J Neurosci 17:1053\u20131066","journal-title":"Eur J Neurosci"},{"key":"2466_CR50","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"1998","unstructured":"Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, New York"},{"key":"2466_CR51","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1016\/j.neuroscience.2004.12.019","volume":"132","author":"M Yano","year":"2005","unstructured":"Yano M, Steiner H (2005) Methylphenidate (Ritalin) induces Homer 1a and zif 268 expression in specific corticostriatal circuits. Neuroscience 132:855\u2013865","journal-title":"Neuroscience"},{"key":"2466_CR52","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1046\/j.1460-9568.2003.02892.x","volume":"18","author":"CL Brandon","year":"2003","unstructured":"Brandon CL, Steiner H (2003) Repeated methylphenidate treatment in adolescent rats alters gene regulation in the striatum. Eur J Neurosci 18:1584\u20131592","journal-title":"Eur J Neurosci"},{"key":"2466_CR53","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1038\/sj.npp.1300613","volume":"30","author":"M Yano","year":"2005","unstructured":"Yano M, Steiner H (2005) Topography of methylphenidate (Ritalin)-induced gene regulation in the striatum: differential effects on c-fos, substance P and opioid peptides. Neuropsychopharmacology 30:901\u2013915","journal-title":"Neuropsychopharmacology"},{"key":"2466_CR54","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1111\/j.1471-4159.2012.07852.x","volume":"122","author":"V Van Waes","year":"2012","unstructured":"Van Waes V, Carr B, Beverley JA, Steiner H (2012) Fluoxetine potentiation of methylphenidate-induced neuropeptide expression in the striatum occurs selectively in direct pathway (striatonigral) neurons. J Neurochem 122:1054\u20131064","journal-title":"J Neurochem"},{"key":"2466_CR55","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1111\/j.1460-9568.2010.07294.x","volume":"32","author":"V Van Waes","year":"2010","unstructured":"Van Waes V, Beverley J, Marinelli M, Steiner H (2010) Selective serotonin reuptake inhibitor antidepressants potentiate methylphenidate (Ritalin)-induced gene regulation in the adolescent striatum. Eur J Neurosci 32:435\u2013447","journal-title":"Eur J Neurosci"},{"key":"2466_CR56","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.pbb.2018.07.001","volume":"172","author":"C Martin","year":"2018","unstructured":"Martin C, Fricke D, Vijayashanthar A, Lowinger C, Koutsomitis D, Popoola D, Hadjiargyrou M, Komatsu DE et al (2018) Recovery from behavior and developmental effects of chronic oral methylphenidate following an abstinence period. Pharmacol Biochem Behav 172:22\u201332","journal-title":"Pharmacol Biochem Behav"},{"key":"2466_CR57","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.bbr.2018.08.014","volume":"356","author":"E Carias","year":"2019","unstructured":"Carias E, Fricke D, Vijayashanthar A, Smith L, Somanesan R, Martin C, Kalinowski L, Popoola D et al (2019) Weekday-only chronic oral methylphenidate self-administration in male rats: reversibility of the behavioral and physiological effects. Behav Brain Res 356:189\u2013196","journal-title":"Behav Brain Res"},{"key":"2466_CR58","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1002\/dev.21902","volume":"62","author":"L Kalinowski","year":"2020","unstructured":"Kalinowski L, Connor C, Somanesan R, Carias E, Richer K, Smith L, Martin C, Mackintosh M et al (2020) Brief and extended abstinence from chronic oral methylphenidate treatment produces reversible behavioral and physiological effects. Dev Psychobiol 62:170\u2013180","journal-title":"Dev Psychobiol"},{"key":"2466_CR59","doi-asserted-by":"publisher","first-page":"1867","DOI":"10.1007\/s00702-018-1931-z","volume":"125","author":"E Carias","year":"2018","unstructured":"Carias E, Hamilton J, Robison LS, Delis F, Eiden R, Quattrin T, Hadjiargyrou M, Komatsu D et al (2018) Chronic oral methylphenidate treatment increases microglial activation in rats. J Neural Transm (Vienna) 125:1867\u20131875","journal-title":"J Neural Transm (Vienna)"},{"issue":"264","key":"2466_CR60","doi-asserted-by":"publisher","first-page":"118708","DOI":"10.1016\/j.lfs.2020.118708","volume":"1","author":"K Jalloh","year":"2021","unstructured":"Jalloh K, Roeder N, Hamilton J, Delis F, Hadjiargyrou M, Komatsu D, Thanos PK (2021) Chronic oral methylphenidate treatment in adolescent rats promotes dose-dependent effects on NMDA receptor binding. Life Sci 1(264):118708","journal-title":"Life Sci"},{"key":"2466_CR61","doi-asserted-by":"crossref","unstructured":"Connor C, Hamilton J, Robison L, Hadjiargyrou M, Komatsu D, Thanos P (2021) Abstinence from chronic methylphenidate exposure modifies cannabinoid receptor 1 levels in the brain in a dose-dependent manner. Curr Pharm Des online ahead of print:","DOI":"10.2174\/1381612827666210127120411"},{"issue":"part B (0 0)","key":"2466_CR62","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.neuropharm.2013.04.004","volume":"76","author":"EJ Nestler","year":"2014","unstructured":"Nestler EJ (2014) Epigenetic mechanisms of drug addiction. Neuropharmacology 76(part B (0 0)):259\u2013268","journal-title":"Neuropharmacology"},{"key":"2466_CR63","doi-asserted-by":"publisher","first-page":"5066","DOI":"10.1523\/JNEUROSCI.13-12-05066.1993","volume":"13","author":"H Steiner","year":"1993","unstructured":"Steiner H, Gerfen CR (1993) Cocaine-induced c-fos messenger RNA is inversely related to dynorphin expression in striatum. J Neurosci 13:5066\u20135081","journal-title":"J Neurosci"},{"key":"2466_CR64","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","volume":"38","author":"NM Barnes","year":"1999","unstructured":"Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083\u20131152","journal-title":"Neuropharmacology"},{"key":"2466_CR65","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1038\/sj.npp.1301445","volume":"33","author":"J Borycz","year":"2008","unstructured":"Borycz J, Zapata A, Quiroz C, Volkow ND, Ferr\u00e9 S (2008) 5-HT(1B) receptor-mediated serotoninergic modulation of methylphenidate-induced locomotor activation in rats. Neuropsychopharmacology 33:619\u2013626","journal-title":"Neuropsychopharmacology"},{"key":"2466_CR66","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1016\/j.cell.2008.10.028","volume":"135","author":"M Heiman","year":"2008","unstructured":"Heiman M, Schaefer A, Gong S, Peterson JD, Day M, Ramsey KE, Su\u00e1rez-Fari\u00f1as M, Schwarz C et al (2008) A translational profiling approach for the molecular characterization of CNS cell types. Cell 135:738\u2013748","journal-title":"Cell"},{"key":"2466_CR67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.3389\/fnana.2011.00041","volume":"5","author":"MK Lobo","year":"2011","unstructured":"Lobo MK, Nestler EJ (2011) The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons. Front Neuroanat 5:41","journal-title":"Front Neuroanat"},{"key":"2466_CR68","doi-asserted-by":"publisher","first-page":"2915","DOI":"10.1073\/pnas.0813179106","volume":"106","author":"Y Kim","year":"2009","unstructured":"Kim Y, Teylan MA, Baron M, Sands A, Nairn AC, Greengard P (2009) Methylphenidate-induced dendritic spine formation and DeltaFosB expression in nucleus accumbens. Proc Natl Acad Sci U S A 106:2915\u20132920","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2466_CR69","first-page":"639","volume-title":"Handbook of Basal Ganglia Structure and Function","author":"H Steiner","year":"2017","unstructured":"Steiner H (2017) Psychostimulant-induced gene regulation in striatal circuits. In: Steiner H, Tseng KY (eds) Handbook of Basal Ganglia Structure and Function. Academic Press\/Elsevier, London, pp 639\u2013672"},{"key":"2466_CR70","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.baga.2014.10.001","volume":"4","author":"JA Beverley","year":"2014","unstructured":"Beverley JA, Piekarski C, Van Waes V, Steiner H (2014) Potentiated gene regulation by methylphenidate plus fluoxetine treatment: long-term gene blunting (Zif268, Homer1a) and behavioral correlates. Basal Ganglia 4:109\u2013116","journal-title":"Basal Ganglia"},{"key":"2466_CR71","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1111\/adb.12067","volume":"19","author":"V Van Waes","year":"2014","unstructured":"Van Waes V, Vandrevala M, Beverley J, Steiner H (2014) Selective serotonin re-uptake inhibitors potentiate gene blunting induced by repeated methylphenidate treatment: Zif268 versus Homer1a. Addict Biol 19:986\u2013995","journal-title":"Addict Biol"},{"key":"2466_CR72","doi-asserted-by":"publisher","first-page":"5301","DOI":"10.1523\/JNEUROSCI.18-14-05301.1998","volume":"18","author":"JD Berke","year":"1998","unstructured":"Berke JD, Paletzki RF, Aronson GJ, Hyman SE, Gerfen CR (1998) A complex program of striatal gene expression induced by dopaminergic stimulation. J Neurosci 18:5301\u20135310","journal-title":"J Neurosci"},{"key":"2466_CR73","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1038\/nn1143","volume":"6","author":"CA McClung","year":"2003","unstructured":"McClung CA, Nestler EJ (2003) Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci 6:1208\u20131215","journal-title":"Nat Neurosci"},{"key":"2466_CR74","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1002\/syn.10198","volume":"48","author":"V Yuferov","year":"2003","unstructured":"Yuferov V, Kroslak T, Laforge KS, Zhou Y, Ho A, Kreek MJ (2003) Differential gene expression in the rat caudate putamen after \u201cbinge\u201d cocaine administration: advantage of triplicate microarray analysis. Synapse 48:157\u2013169","journal-title":"Synapse"},{"key":"2466_CR75","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1080\/13556210412331308976","volume":"10","author":"V Yuferov","year":"2005","unstructured":"Yuferov V, Nielsen D, Butelman E, Kreek MJ (2005) Microarray studies of psychostimulant-induced changes in gene expression. Addict Biol 10:101\u2013118","journal-title":"Addict Biol"},{"key":"2466_CR76","doi-asserted-by":"publisher","first-page":"9656","DOI":"10.1523\/JNEUROSCI.2391-06.2006","volume":"26","author":"YD Black","year":"2006","unstructured":"Black YD, Maclaren FR, Naydenov AV, Carlezon WAJ, Baxter MG, Konradi C (2006) Altered attention and prefrontal cortex gene expression in rats after binge-like exposure to cocaine during adolescence. J Neurosci 26:9656\u20139665","journal-title":"J Neurosci"},{"key":"2466_CR77","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1038\/sj.npp.1300962","volume":"31","author":"W Adriani","year":"2006","unstructured":"Adriani W, Leo D, Greco D, Rea M, di Porzio U, Laviola G, Perrone-Capano C (2006) Methylphenidate administration to adolescent rats determines plastic changes in reward-related behavior and striatal gene expression. Neuropsychopharmacology 31:1946\u20131956","journal-title":"Neuropsychopharmacology"},{"key":"2466_CR78","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1196\/annals.1369.005","volume":"1074","author":"W Adriani","year":"2006","unstructured":"Adriani W, Leo D, Guarino M, Natoli A, Di Consiglio E, De Angelis G, Traina E, Testai E et al (2006) Short-term effects of adolescent methylphenidate exposure on brain striatal gene expression and sexual\/endocrine parameters in male rats. Ann N Y Acad Sci 1074:52\u201373","journal-title":"Ann N Y Acad Sci"},{"key":"2466_CR79","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/S0165-0173(97)00021-0","volume":"25","author":"RC Pierce","year":"1997","unstructured":"Pierce RC, Kalivas PW (1997) A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants. Brain Res Rev 25:192\u2013216","journal-title":"Brain Res Rev"},{"key":"2466_CR80","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0028-3908(98)00033-1","volume":"37","author":"BW Balleine","year":"1998","unstructured":"Balleine BW, Dickinson A (1998) Goal-directed instrumental action: contingency and incentive learning and their cortical substrates. Neuropharmacology 37:407\u2013419","journal-title":"Neuropharmacology"},{"key":"2466_CR81","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1038\/nrn1919","volume":"7","author":"HH Yin","year":"2006","unstructured":"Yin HH, Knowlton BJ (2006) The role of the basal ganglia in habit formation. Nat Rev Neurosci 7:464\u2013476","journal-title":"Nat Rev Neurosci"},{"key":"2466_CR82","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/S0896-6273(00)81056-9","volume":"25","author":"JD Berke","year":"2000","unstructured":"Berke JD, Hyman SE (2000) Addiction, dopamine, and the molecular mechanisms of memory. Neuron 25:515\u2013532","journal-title":"Neuron"},{"key":"2466_CR83","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/S0166-2236(03)00065-1","volume":"26","author":"GL Gerdeman","year":"2003","unstructured":"Gerdeman GL, Partridge JG, Lupica CR, Lovinger DM (2003) It could be habit forming: drugs of abuse and striatal synaptic plasticity. Trends Neurosci 26:184\u2013192","journal-title":"Trends Neurosci"},{"key":"2466_CR84","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1038\/nn1579","volume":"8","author":"BJ Everitt","year":"2005","unstructured":"Everitt BJ, Robbins TW (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion. Nat Neurosci 8:1481\u20131489","journal-title":"Nat Neurosci"},{"key":"2466_CR85","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.biopsych.2012.07.001","volume":"72","author":"A Belin-Rauscent","year":"2012","unstructured":"Belin-Rauscent A, Everitt BJ, Belin D (2012) Intrastriatal shifts mediate the transition from drug-seeking actions to habits. Biol Psychiatry 72:343\u2013345","journal-title":"Biol Psychiatry"},{"key":"2466_CR86","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1111\/gbb.12309","volume":"16","author":"CM Gremel","year":"2017","unstructured":"Gremel CM, Lovinger DM (2017) Associative and sensorimotor cortico-basal ganglia circuit roles in effects of abused drugs. Genes Brain Behav 16:71\u201385","journal-title":"Genes Brain Behav"},{"key":"2466_CR87","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1111\/j.1460-9568.2007.05316.x","volume":"25","author":"JP Jedynak","year":"2007","unstructured":"Jedynak JP, Uslaner JM, Esteban JA, Robinson TE (2007) Methamphetamine-induced structural plasticity in the dorsal striatum. Eur J Neurosci 25:847\u2013853","journal-title":"Eur J Neurosci"},{"key":"2466_CR88","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1111\/ejn.12644","volume":"40","author":"BJ Everitt","year":"2014","unstructured":"Everitt BJ (2014) Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories\u2013indications for novel treatments of addiction. Eur J Neurosci 40:2163\u20132182","journal-title":"Eur J Neurosci"},{"key":"2466_CR89","doi-asserted-by":"publisher","first-page":"8665","DOI":"10.1523\/JNEUROSCI.0925-05.2005","volume":"25","author":"LJ Vanderschuren","year":"2005","unstructured":"Vanderschuren LJ, Di Ciano P, Everitt BJ (2005) Involvement of the dorsal striatum in cue-controlled cocaine seeking. J Neurosci 25:8665\u20138670","journal-title":"J Neurosci"},{"key":"2466_CR90","doi-asserted-by":"publisher","first-page":"3584","DOI":"10.1523\/JNEUROSCI.5146-05.2006","volume":"26","author":"RA Fuchs","year":"2006","unstructured":"Fuchs RA, Branham RK, See RE (2006) Different neural substrates mediate cocaine seeking after abstinence versus extinction training: a critical role for the dorsolateral caudate\u2013putamen. J Neuroscience 26:3584\u20133588","journal-title":"J Neuroscience"},{"key":"2466_CR91","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1007\/s00213-007-0850-8","volume":"194","author":"RE See","year":"2007","unstructured":"See RE, Elliott JC, Feltenstein MW (2007) The role of dorsal vs ventral striatal pathways in cocaine-seeking behavior after prolonged abstinence in rats. Psychopharmacology 194:321\u2013331","journal-title":"Psychopharmacology"},{"key":"2466_CR92","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1146\/annurev.ne.09.030186.002041","volume":"9","author":"GE Alexander","year":"1986","unstructured":"Alexander GE, DeLong MR, Strick PL (1986) Parallel organization of functionally segregated circuits linking basal ganglia and cortex. Annu Rev Neurosci 9:357\u2013381","journal-title":"Annu Rev Neurosci"},{"key":"2466_CR93","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0166-2236(89)90074-X","volume":"12","author":"RL Albin","year":"1989","unstructured":"Albin RL, Young AB, Penney JB (1989) The functional anatomy of basal ganglia disorders. Trends Neurosci 12:366\u2013375","journal-title":"Trends Neurosci"},{"key":"2466_CR94","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1038\/nature09159","volume":"466","author":"AV Kravitz","year":"2010","unstructured":"Kravitz AV, Freeze BS, Parker PR, Kay K, Thwin MT, Deisseroth K, Kreitzer AC (2010) Regulation of parkinsonian motor behaviours by optogenetic control of basal ganglia circuitry. Nature 466:622\u2013626","journal-title":"Nature"},{"key":"2466_CR95","doi-asserted-by":"publisher","first-page":"18531","DOI":"10.1523\/JNEUROSCI.1278-13.2013","volume":"33","author":"BS Freeze","year":"2013","unstructured":"Freeze BS, Kravitz AV, Hammack N, Berke JD, Kreitzer AC (2013) Control of basal ganglia output by direct and indirect pathway projection neurons. J Neurosci 33:18531\u201318539","journal-title":"J Neurosci"},{"key":"2466_CR96","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1126\/science.1188472","volume":"330","author":"MK Lobo","year":"2010","unstructured":"Lobo MK, Covington HE, Chaudhury D, Friedman AK, Sun H, Damez-Werno D, Dietz DM, Zaman S et al (2010) Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward. Science 330:385\u2013390","journal-title":"Science"},{"key":"2466_CR97","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nn.2703","volume":"14","author":"SM Ferguson","year":"2011","unstructured":"Ferguson SM, Eskenazi D, Ishikawa M, Wanat MJ, Phillips PE, Dong Y, Roth BL, Neumaier JF (2011) Transient neuronal inhibition reveals opposing roles of indirect and direct pathways in sensitization. Nat Neurosci 14:22\u201324","journal-title":"Nat Neurosci"},{"key":"2466_CR98","first-page":"167","volume":"27","author":"AV Kravitz","year":"2012","unstructured":"Kravitz AV, Kreitzer AC (2012) Striatal mechanisms underlying movement, reinforcement, and punishment. Physiology (Bethesda) 27:167\u2013177","journal-title":"Physiology (Bethesda)"},{"key":"2466_CR99","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.tins.2020.10.005","volume":"44","author":"DM Lovinger","year":"2021","unstructured":"Lovinger DM, Gremel CM (2021) A circuit-based information approach to substance abuse research. Trends Neurosci 44:122\u2013135","journal-title":"Trends Neurosci"},{"key":"2466_CR100","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0893-133X(01)00281-0","volume":"25","author":"CL Brandon","year":"2001","unstructured":"Brandon CL, Marinelli M, Baker LK, White FJ (2001) Enhanced reactivity and vulnerability to cocaine following methylphenidate treatment in adolescent rats. Neuropsychopharmacology 25:651\u2013661","journal-title":"Neuropsychopharmacology"},{"key":"2466_CR101","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/S0091-3057(02)00735-9","volume":"72","author":"S Schenk","year":"2002","unstructured":"Schenk S, Izenwasser S (2002) Pretreatment with methylphenidate sensitizes rats to the reinforcing effects of cocaine. Pharmacol Biochem Behav 72:651\u2013657","journal-title":"Pharmacol Biochem Behav"},{"key":"2466_CR102","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s00213-010-2011-8","volume":"213","author":"CA Crawford","year":"2011","unstructured":"Crawford CA, Baella SA, Farley CM, Herbert MS, Horn LR, Campbell RH, Zavala AR (2011) Early methylphenidate exposure enhances cocaine self-administration but not cocaine-induced conditioned place preference in young adult rats. Psychopharmacology 213:43\u201352","journal-title":"Psychopharmacology"},{"key":"2466_CR103","doi-asserted-by":"publisher","first-page":"10347","DOI":"10.1523\/JNEUROSCI.1470-11.2011","volume":"31","author":"BL Warren","year":"2011","unstructured":"Warren BL, I\u00f1iguez SD, Alcantara LF, Wright KN, Parise EM, Weakley SK, Bola\u00f1os-Guzm\u00e1n CA (2011) Juvenile administration of concomitant methylphenidate and fluoxetine alters behavioral reactivity to reward- and mood-related stimuli and disrupts ventral tegmental area gene expression in adulthood. J Neurosci 31:10347\u201310358","journal-title":"J Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02466-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02466-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02466-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T06:33:00Z","timestamp":1633674780000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02466-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":103,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2466"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02466-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]},"assertion":[{"value":"6 April 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures followed the guidelines as described in the \u201cGuide for the Care and Use of Laboratory Rats\u201d (National Academy of Science and NRC, 1996) and were approved by the State University at Buffalo Institutional Animal Care and Use Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}