{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T04:25:14Z","timestamp":1782361514445,"version":"3.54.5"},"reference-count":56,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2008\/55178-0"],"award-info":[{"award-number":["2008\/55178-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/24727-4"],"award-info":[{"award-number":["2012\/24727-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/03572-3"],"award-info":[{"award-number":["2016\/03572-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2006\/52566-4"],"award-info":[{"award-number":["2006\/52566-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2012\/24002-0"],"award-info":[{"award-number":["2012\/24002-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2010\/52068-0"],"award-info":[{"award-number":["2010\/52068-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/02224-1"],"award-info":[{"award-number":["2016\/02224-1"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["479153\/2009-4"],"award-info":[{"award-number":["479153\/2009-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["422523\/2016-0"],"award-info":[{"award-number":["422523\/2016-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["160570\/2012-3"],"award-info":[{"award-number":["160570\/2012-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["426378\/2016-4"],"award-info":[{"award-number":["426378\/2016-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PNPD"],"award-info":[{"award-number":["PNPD"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES-COFECUB 848\/15"],"award-info":[{"award-number":["CAPES-COFECUB 848\/15"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s12035-021-02470-2","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T01:02:34Z","timestamp":1625187754000},"page":"4871-4885","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Norepinephrine and Glucocorticoids Modulate Chronic Unpredictable Stress-Induced Increase in the Type 2 CRF and Glucocorticoid Receptors in Brain Structures Related to the HPA Axis Activation"],"prefix":"10.1007","volume":"58","author":[{"given":"Marilia B.","family":"Malta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelcimar","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo S.","family":"Novaes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilton B.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciane","family":"Sita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Camarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristoforo","family":"Scavone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson","family":"Bittencourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-5234","authenticated-orcid":false,"given":"Carolina D.","family":"Munhoz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"issue":"6","key":"2470_CR1","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrn2647","volume":"10","author":"YM Ulrich-Lai","year":"2009","unstructured":"Ulrich-Lai YM, Herman JP (2009) Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 10(6):397\u2013409","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"2470_CR2","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/j.1365-2826.2008.01707.x","volume":"20","author":"ER de Kloet","year":"2008","unstructured":"de Kloet ER (2008) About stress hormones and resilience to psychopathology. J Neuroendocrinol 20(6):885\u2013892","journal-title":"J Neuroendocrinol"},{"issue":"1","key":"2470_CR3","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1080\/102538902900012345","volume":"5","author":"DS Goldstein","year":"2002","unstructured":"Goldstein DS, McEwen B (2002) Allostasis, homeostats, and the nature of stress. Stress 5(1):55\u201358","journal-title":"Stress"},{"issue":"1","key":"2470_CR4","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1007\/s10198-004-0251-4","volume":"6","author":"S Bejean","year":"2005","unstructured":"Bejean S, Sultan-Taieb H (2005) Modeling the economic burden of diseases imputable to stress at work. Eur J Health Econ 6(1):16\u201323","journal-title":"Eur J Health Econ"},{"issue":"6","key":"2470_CR5","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1038\/nrn1683","volume":"6","author":"ER de Kloet","year":"2005","unstructured":"de Kloet ER, Joels M, Holsboer F (2005) Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6(6):463\u2013475","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"2470_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/frne.1998.0172","volume":"20","author":"LD Van de Kar","year":"1999","unstructured":"Van de Kar LD, Blair ML (1999) Forebrain pathways mediating stress-induced hormone secretion. Front Neuroendocrinol 20(1):1\u201348","journal-title":"Front Neuroendocrinol"},{"key":"2470_CR7","first-page":"773","volume-title":"psychopharmacology: the fourth generation of progress","author":"HA Akil","year":"1995","unstructured":"Akil HA, Morano MI (1995) Stress. In: Bloom FE, Kupfer DJ (eds) psychopharmacology: the fourth generation of progress. Raven Press, New York, pp 773\u2013785"},{"key":"2470_CR8","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1093\/protein\/6.2.149","volume":"6","author":"C Romier","year":"1993","unstructured":"Romier C et al (1993) Solution of structure of human corticotropin releasing factor by HNMR and distance geometry with restrained molecular dynamics. Prot Eng 6:149\u2013156","journal-title":"Prot Eng"},{"issue":"2","key":"2470_CR9","first-page":"412","volume":"80","author":"PJ Trainer","year":"1995","unstructured":"Trainer PJ et al (1995) A comparison of the effects of human and ovine corticotropin-releasing hormone on the pituitary-adrenal axis. J Clin Endocrinol Metab 80(2):412\u2013417","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2470_CR10","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1210\/er.2005-0034","volume":"27","author":"EW Hillhouse","year":"2006","unstructured":"Hillhouse EW, Grammatopoulos DK (2006) The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Endocr Rev 27(3):260\u2013286","journal-title":"Endocr Rev"},{"key":"2470_CR11","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1196\/annals.1296.003","volume":"1018","author":"AJ Dunn","year":"2004","unstructured":"Dunn AJ, Swiergiel AH, Palamarchouk V (2004) Brain circuits involved in corticotropin-releasing factor-norepinephrine interactions during stress. Ann N Y Acad Sci 1018:25\u201334","journal-title":"Ann N Y Acad Sci"},{"issue":"2\u20133","key":"2470_CR12","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ejphar.2007.11.075","volume":"583","author":"JP Gallagher","year":"2008","unstructured":"Gallagher JP et al (2008) Synaptic physiology of central CRH system. Eur J Pharmacol 583(2\u20133):215\u2013225","journal-title":"Eur J Pharmacol"},{"issue":"10","key":"2470_CR13","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1038\/nrn.2016.94","volume":"17","author":"MJ Henckens","year":"2016","unstructured":"Henckens MJ, Deussing JM, Chen A (2016) Region-specific roles of the corticotropin-releasing factor-urocortin system in stress. Nat Rev Neurosci 17(10):636\u2013651","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"2470_CR14","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1080\/10253890500504557","volume":"8","author":"A Shekhar","year":"2005","unstructured":"Shekhar A et al (2005) Role of stress, corticotrophin releasing factor (CRF) and amygdala plasticity in chronic anxiety. Stress 8(4):209\u2013219","journal-title":"Stress"},{"issue":"4","key":"2470_CR15","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/74263","volume":"24","author":"TL Bale","year":"2000","unstructured":"Bale TL et al (2000) Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat Genet 24(4):410\u2013414","journal-title":"Nat Genet"},{"issue":"4","key":"2470_CR16","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1038\/74255","volume":"24","author":"SC Coste","year":"2000","unstructured":"Coste SC et al (2000) Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Nat Genet 24(4):403\u2013409","journal-title":"Nat Genet"},{"issue":"3","key":"2470_CR17","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neuroscience.2003.10.042","volume":"123","author":"T Kozicz","year":"2004","unstructured":"Kozicz T et al (2004) Urocortin expression in the Edinger-Westphal nucleus is down-regulated in transgenic mice over-expressing neuronal corticotropin-releasing factor. Neuroscience 123(3):589\u2013594","journal-title":"Neuroscience"},{"issue":"1","key":"2470_CR18","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S1471-4892(01)00117-5","volume":"2","author":"JM Reul","year":"2002","unstructured":"Reul JM, Holsboer F (2002) Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol 2(1):23\u201333","journal-title":"Curr Opin Pharmacol"},{"key":"2470_CR19","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1146\/annurev.pharmtox.44.101802.121410","volume":"44","author":"TL Bale","year":"2004","unstructured":"Bale TL, Vale WW (2004) CRF and CRF receptors: role in stress responsivity and other behaviors. Annu Rev Pharmacol Toxicol 44:525\u2013557","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"12","key":"2470_CR20","doi-asserted-by":"publisher","first-page":"1283","DOI":"10.1038\/mp.2011.119","volume":"17","author":"M Ingallinesi","year":"2012","unstructured":"Ingallinesi M et al (2012) CRF2 receptor-deficiency eliminates opiate withdrawal distress without impairing stress coping. Mol Psychiatry 17(12):1283\u20131294","journal-title":"Mol Psychiatry"},{"issue":"1\u20133","key":"2470_CR21","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0014-2999(03)01285-8","volume":"463","author":"GA Carrasco","year":"2003","unstructured":"Carrasco GA, Van de Kar LD (2003) Neuroendocrine pharmacology of stress. Eur J Pharmacol 463(1\u20133):235\u2013272","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"2470_CR22","doi-asserted-by":"publisher","first-page":"1161","DOI":"10.1002\/cphy.c140065","volume":"5","author":"M Keller-Wood","year":"2015","unstructured":"Keller-Wood M (2015) Hypothalamic-pituitary-adrenal axis\u2014feedback control. Compr Physiol 5(3):1161\u20131182","journal-title":"Compr Physiol"},{"key":"2470_CR23","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1056\/NEJM199801153380307","volume":"338","author":"BS McEwen","year":"1998","unstructured":"McEwen BS (1998) Protective and damaging effects of stress mediators. N Engl J Med 338:171\u2013179","journal-title":"N Engl J Med"},{"issue":"2","key":"2470_CR24","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/0959-4388(95)80028-X","volume":"5","author":"BS McEwen","year":"1995","unstructured":"McEwen BS, Sapolsky RM (1995) Stress and cognitive function. Curr Opin Neurobiol 5(2):205\u2013216","journal-title":"Curr Opin Neurobiol"},{"key":"2470_CR25","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1196\/annals.1314.003","volume":"1032","author":"ER De Kloet","year":"2004","unstructured":"De Kloet ER, Derijk R (2004) Signaling pathways in brain involved in predisposition and pathogenesis of stress-related disease: genetic and kinetic factors affecting the MR\/GR balance. Ann N Y Acad Sci 1032:14\u201334","journal-title":"Ann N Y Acad Sci"},{"key":"2470_CR26","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","volume":"6","author":"P Willner","year":"2017","unstructured":"Willner P (2017) The chronic mild stress (CMS) model of depression: history, evaluation and usage. Neurobiol Stress 6:78\u201393","journal-title":"Neurobiol Stress"},{"issue":"4","key":"2470_CR27","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1080\/10253890500070005","volume":"7","author":"M Joels","year":"2004","unstructured":"Joels M et al (2004) Effects of chronic stress on structure and cell function in rat hippocampus and hypothalamus. Stress 7(4):221\u2013231","journal-title":"Stress"},{"issue":"2","key":"2470_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000087097","volume":"52","author":"P Willner","year":"2005","unstructured":"Willner P (2005) Chronic mild stress (CMS) revisited: consistency and behavioural-neurobiological concordance in the effects of CMS. Neuropsychobiology 52(2):90\u2013110","journal-title":"Neuropsychobiology"},{"issue":"14","key":"2470_CR29","doi-asserted-by":"publisher","first-page":"3813","DOI":"10.1523\/JNEUROSCI.4398-05.2006","volume":"26","author":"CD Munhoz","year":"2006","unstructured":"Munhoz CD et al (2006) Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion. J Neurosci 26(14):3813\u20133820","journal-title":"J Neurosci"},{"issue":"5","key":"2470_CR30","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1002\/syn.20497","volume":"62","author":"DA Tata","year":"2008","unstructured":"Tata DA, Yamamoto BK (2008) Chronic stress enhances methamphetamine-induced extracellular glutamate and excitotoxicity in the rat striatum. Synapse 62(5):325\u2013336","journal-title":"Synapse"},{"issue":"4","key":"2470_CR31","doi-asserted-by":"publisher","first-page":"1969","DOI":"10.1210\/en.2007-0482","volume":"149","author":"B Garcia-Bueno","year":"2008","unstructured":"Garcia-Bueno B et al (2008) Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. Endocrinology 149(4):1969\u20131978","journal-title":"Endocrinology"},{"issue":"3","key":"2470_CR32","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1179\/014788889794651870","volume":"12","author":"DM Simmons","year":"1989","unstructured":"Simmons DM, Arriza JL, Swanson LW (1989) A Complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radio-labeled single-stranded RNA probes. J Histotechnol 12(3):169\u2013181","journal-title":"J Histotechnol"},{"issue":"4","key":"2470_CR33","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1177\/29.4.6166661","volume":"29","author":"SM Hsu","year":"1981","unstructured":"Hsu SM, Raine L, Fanger H (1981) Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29(4):577\u2013580","journal-title":"J Histochem Cytochem"},{"key":"2470_CR34","volume-title":"Pratical nonparametric statistics","author":"WJ Conover","year":"1999","unstructured":"Conover WJ (1999) Pratical nonparametric statistics, 3rd edn. Wiley, Hoboken","edition":"3rd ed"},{"issue":"39","key":"2470_CR35","doi-asserted-by":"publisher","first-page":"10568","DOI":"10.1523\/JNEUROSCI.3044-06.2007","volume":"27","author":"VP Bakshi","year":"2007","unstructured":"Bakshi VP et al (2007) Stimulation of lateral septum CRF2 receptors promotes anorexia and stress-like behaviors: functional homology to CRF1 receptors in basolateral amygdala. J Neurosci 27(39):10568\u201310577","journal-title":"J Neurosci"},{"issue":"4","key":"2470_CR36","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1073\/pnas.1114122109","volume":"109","author":"FD Jeanneteau","year":"2012","unstructured":"Jeanneteau FD et al (2012) BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci U S A 109(4):1305\u20131310","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2470_CR37","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1038\/scientificamerican0903-86","volume":"289","author":"R Sapolsky","year":"2003","unstructured":"Sapolsky R (2003) Taming stress. Sci Am 289(3):86\u201395","journal-title":"Sci Am"},{"issue":"7","key":"2470_CR38","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1002\/da.20546","volume":"26","author":"MA Kling","year":"2009","unstructured":"Kling MA, Coleman VH, Schulkin J (2009) Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? Depress Anxiety 26(7):641\u2013649","journal-title":"Depress Anxiety"},{"issue":"3","key":"2470_CR39","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.yfrne.2003.07.001","volume":"24","author":"JP Herman","year":"2003","unstructured":"Herman JP et al (2003) Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 24(3):151\u2013180","journal-title":"Front Neuroendocrinol"},{"issue":"9","key":"2470_CR40","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/S0006-3223(99)00164-X","volume":"46","author":"GF Koob","year":"1999","unstructured":"Koob GF (1999) Corticotropin-releasing factor, norepinephrine, and stress. Biol Psychiatry 46(9):1167\u20131180","journal-title":"Biol Psychiatry"},{"issue":"2\u20133","key":"2470_CR41","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1016\/j.ejphar.2007.11.066","volume":"583","author":"A Korosi","year":"2008","unstructured":"Korosi A, Baram TZ (2008) The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol 583(2\u20133):204\u2013214","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"2470_CR42","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0166-2236(96)10069-2","volume":"20","author":"JP Herman","year":"1997","unstructured":"Herman JP, Cullinan WE (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci 20(2):78\u201384","journal-title":"Trends Neurosci"},{"issue":"11","key":"2470_CR43","doi-asserted-by":"publisher","first-page":"1903","DOI":"10.1111\/ejn.12587","volume":"39","author":"JN Flak","year":"2014","unstructured":"Flak JN et al (2014) Role of paraventricular nucleus-projecting norepinephrine\/epinephrine neurons in acute and chronic stress. Eur J Neurosci 39(11):1903\u20131911","journal-title":"Eur J Neurosci"},{"key":"2470_CR44","doi-asserted-by":"publisher","first-page":"243","DOI":"10.3389\/fnins.2017.00243","volume":"11","author":"B Wang","year":"2017","unstructured":"Wang B et al (2017) Effects of alpha2A adrenoceptors on norepinephrine secretion from the locus coeruleus during chronic stress-induced depression. Front Neurosci 11:243","journal-title":"Front Neurosci"},{"issue":"8","key":"2470_CR45","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1111\/j.2042-7158.1991.tb03545.x","volume":"43","author":"P Agon","year":"1991","unstructured":"Agon P et al (1991) Permeability of the blood-brain barrier for atenolol studied by positron emission tomography. J Pharm Pharmacol 43(8):597\u2013600","journal-title":"J Pharm Pharmacol"},{"issue":"1\u20132","key":"2470_CR46","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/S0006-8993(02)02467-8","volume":"938","author":"JL Madrigal","year":"2002","unstructured":"Madrigal JL et al (2002) Stress-induced increase in extracellular sucrose space in rats is mediated by nitric oxide. Brain Res 938(1\u20132):87\u201391","journal-title":"Brain Res"},{"key":"2470_CR47","first-page":"17","volume-title":"Handbook of Stress Series","author":"JJ Radley","year":"2017","unstructured":"Radley JJ, Johnson SB, Sawchenko PE (2017) Stress: neuroendocrinology and neurobiology. In: Fink G (ed) Handbook of Stress Series. Academic Press, New York, pp 17\u201327"},{"issue":"8","key":"2470_CR48","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1016\/j.pnpbp.2005.08.007","volume":"29","author":"DA Morilak","year":"2005","unstructured":"Morilak DA et al (2005) Role of brain norepinephrine in the behavioral response to stress. Prog Neuropsychopharmacol Biol Psychiatry 29(8):1214\u20131224","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"8","key":"2470_CR49","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.pnpbp.2005.08.006","volume":"29","author":"JP Herman","year":"2005","unstructured":"Herman JP et al (2005) Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 29(8):1201\u20131213","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"issue":"4","key":"2470_CR50","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1038\/npp.2010.213","volume":"36","author":"GM Singewald","year":"2011","unstructured":"Singewald GM et al (2011) The modulatory role of the lateral septum on neuroendocrine and behavioral stress responses. Neuropsychopharmacology 36(4):793\u2013804","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"2470_CR51","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/mp.2014.163","volume":"20","author":"PW Gold","year":"2015","unstructured":"Gold PW (2015) The organization of the stress system and its dysregulation in depressive illness. Mol Psychiatry 20(1):32\u201347","journal-title":"Mol Psychiatry"},{"key":"2470_CR52","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3389\/fncel.2017.00087","volume":"11","author":"M van Bodegom","year":"2017","unstructured":"van Bodegom M, Homberg JR, Henckens M (2017) Modulation of the hypothalamic-pituitary-adrenal axis by early life stress exposure. Front Cell Neurosci 11:87","journal-title":"Front Cell Neurosci"},{"issue":"36","key":"2470_CR53","doi-asserted-by":"publisher","first-page":"9142","DOI":"10.1523\/JNEUROSCI.1494-06.2006","volume":"26","author":"B Henry","year":"2006","unstructured":"Henry B, Vale W, Markou A (2006) The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci 26(36):9142\u20139152","journal-title":"J Neurosci"},{"issue":"12","key":"2470_CR54","doi-asserted-by":"publisher","first-page":"1389","DOI":"10.1016\/S0006-3223(03)00465-7","volume":"54","author":"M Heinrichs","year":"2003","unstructured":"Heinrichs M et al (2003) Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry 54(12):1389\u20131398","journal-title":"Biol Psychiatry"},{"key":"2470_CR55","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev.clinpsy.1.102803.143948","volume":"1","author":"SM Southwick","year":"2005","unstructured":"Southwick SM, Vythilingam M, Charney DS (2005) The psychobiology of depression and resilience to stress: implications for prevention and treatment. Annu Rev Clin Psychol 1:255\u2013291","journal-title":"Annu Rev Clin Psychol"},{"key":"2470_CR56","first-page":"629","volume-title":"Handbook of life stress, cognition and health","author":"P Sterling","year":"1988","unstructured":"Sterling P, Eyer J (1988) Allostasis: a new paradigm to explain arousal pathology. In: Fisher S, Reason J (eds) Handbook of life stress, cognition and health. Wiley, New York, pp 629\u2013649"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02470-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02470-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T02:33:37Z","timestamp":1633660417000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02470-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":56,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["2470"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02470-2","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.02.02.429424","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]},"assertion":[{"value":"2 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animals were used following the standards of the Ethics Committee for Animal Use of the Institute of Biomedical Sciences\/University of S\u00e3o Paulo (CEUA- ICB 102\/06 and 75\/05) and the guidelines of the Brazilian National Council for the Control of Animal Experimentation (CONCEA).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have contributed significantly and agreed with the entire content of this manuscript.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}