{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T13:10:09Z","timestamp":1781788209831,"version":"3.54.5"},"reference-count":61,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100004935","name":"s\u00fcleyman demirel \u00fcniversitesi","doi-asserted-by":"publisher","award":["TDK-2020-7448"],"award-info":[{"award-number":["TDK-2020-7448"]}],"id":[{"id":"10.13039\/501100004935","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s12035-021-02503-w","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T06:02:46Z","timestamp":1628488966000},"page":"5581-5601","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Involvement of TRPM2 in the Neurobiology of Experimental Migraine: Focus on Oxidative Stress and Apoptosis"],"prefix":"10.1007","volume":"58","author":[{"given":"Yener","family":"Yaz\u011fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Naz\u0131ro\u011flu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"issue":"10283","key":"2503_CR1","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/S0140-6736(20)32160-7","volume":"397","author":"M Ashina","year":"2021","unstructured":"Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, \u00d6zge A et al (2021) Migraine: epidemiology and systems of care. Lancet 397(10283):1485\u20131495. https:\/\/doi.org\/10.1016\/S0140-6736(20)32160-7","journal-title":"Lancet"},{"issue":"6","key":"2503_CR2","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.950","volume":"8","author":"WZ Yeh","year":"2018","unstructured":"Yeh WZ, Blizzard L, Taylor BV (2018) What is the actual prevalence of migraine? Brain Behav 8(6):e00950. https:\/\/doi.org\/10.1002\/brb3.950","journal-title":"Brain Behav"},{"issue":"2","key":"2503_CR3","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1111\/jnc.12615","volume":"129","author":"PA Abushik","year":"2014","unstructured":"Abushik PA, Niittykoski M, Giniatullina R, Shakirzyanova A, Bart G, Fayuk D, Sibarov DA, Antonov SM et al (2014) The role of NMDA and mGluR5 receptors in calcium mobilization and neurotoxicity of homocysteine in trigeminal and cortical neurons and glial cells. J Neurochem 129(2):264\u2013274. https:\/\/doi.org\/10.1111\/jnc.12615","journal-title":"J Neurochem"},{"key":"2503_CR4","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.neuroscience.2013.09.002","volume":"253","author":"A Shatillo","year":"2013","unstructured":"Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M et al (2013) Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system. Neuroscience 253:341\u2013349. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.09.002","journal-title":"Neuroscience"},{"key":"2503_CR5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2019.112518","volume":"251","author":"HJ Park","year":"2020","unstructured":"Park HJ, Kwak M, Baek SH (2020) Neuroprotective effects of Dendropanax morbifera leaves on glutamate-induced oxidative cell death in HT22 mouse hippocampal neuronal cells. J Ethnopharmacol 251:112518. https:\/\/doi.org\/10.1016\/j.jep.2019.112518","journal-title":"J Ethnopharmacol"},{"key":"2503_CR6","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neulet.2016.10.054","volume":"636","author":"X Dong","year":"2017","unstructured":"Dong X, Guan X, Chen K, Jin S, Wang C, Yan L, Shi Z, Zhang X et al (2017) Abnormal mitochondrial dynamics and impaired mitochondrial biogenesis in trigeminal ganglion neurons in a rat model of migraine. Neurosci Lett 636:127\u2013133. https:\/\/doi.org\/10.1016\/j.neulet.2016.10.054","journal-title":"Neurosci Lett"},{"issue":"4","key":"2503_CR7","doi-asserted-by":"publisher","first-page":"3647","DOI":"10.1002\/jcp.27134","volume":"234","author":"X Li","year":"2019","unstructured":"Li X, Jiang LH (2019) A critical role of the transient receptor potential melastatin 2 channel in a positive feedback mechanism for reactive oxygen species-induced delayed cell death. J Cell Physiol 234(4):3647\u20133660. https:\/\/doi.org\/10.1002\/jcp.27134","journal-title":"J Cell Physiol"},{"issue":"8","key":"2503_CR8","doi-asserted-by":"publisher","first-page":"2312","DOI":"10.1093\/brain\/awy177","volume":"141","author":"IM Marone","year":"2018","unstructured":"Marone IM, De Logu F, Nassini R, De Carvalho GM, Benemei S, Ferreira J, Jain P et al (2018) TRPA1\/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice. Brain 141(8):2312\u20132328. https:\/\/doi.org\/10.1093\/brain\/awy177","journal-title":"Brain"},{"issue":"1","key":"2503_CR9","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/head.12725","volume":"56","author":"JM Borkum","year":"2016","unstructured":"Borkum JM (2016) Migraine triggers and oxidative stress: A narrative review and synthesis. Headache 56(1):12\u201335. https:\/\/doi.org\/10.1111\/head.12725","journal-title":"Headache"},{"issue":"1","key":"2503_CR10","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1007\/s12011-014-0199-x","volume":"164","author":"M Naz\u0131ro\u011flu","year":"2015","unstructured":"Naz\u0131ro\u011flu M, \u00c7elik \u00d6, U\u011fuz AC, B\u00fct\u00fcn A (2015) Protective effects of riboflavin and selenium on brain microsomal Ca2+-ATPase and oxidative damage caused by glyceryl trinitrate in a rat headache model. Biol Trace Elem Res 164(1):72\u201379. https:\/\/doi.org\/10.1007\/s12011-014-0199-x","journal-title":"Biol Trace Elem Res"},{"issue":"2","key":"2503_CR11","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s00232-014-9758-5","volume":"248","author":"A B\u00fct\u00fcn","year":"2015","unstructured":"B\u00fct\u00fcn A, Naz\u0131ro\u011flu M, Demirci S, \u00c7elik \u00d6, U\u011fuz AC (2015) Riboflavin and vitamin E increase brain calcium and antioxidants, and microsomal calcium-ATP-ase values in rat headache models induced by glyceryl trinitrate. J Membr Biol 248(2):205\u2013213. https:\/\/doi.org\/10.1007\/s00232-014-9758-5","journal-title":"J Membr Biol"},{"issue":"1 2","key":"2503_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11010-011-0913-3","volume":"358","author":"M Ishii","year":"2011","unstructured":"Ishii M, Iizuka R, Kiuchi Y, Mori Y, Shimizu S (2011) Neuroprotection by lomerizine, a prophylactic drug for migraine, against hydrogen peroxide-induced hippocampal neurotoxicity. Mol Cell Biochem 358(1 2):1\u201311. https:\/\/doi.org\/10.1007\/s11010-011-0913-3","journal-title":"Mol Cell Biochem"},{"key":"2503_CR13","doi-asserted-by":"publisher","first-page":"95","DOI":"10.3389\/fphys.2018.00095","volume":"9","author":"C Carrasco","year":"2018","unstructured":"Carrasco C, Naziro\u01e7lu M, Rodr\u00edguez AB, Pariente JA (2018) Neuropathic pain: Delving into the oxidative origin and the possible implication of transient receptor potential channels. Front Physiol 9:95. https:\/\/doi.org\/10.3389\/fphys.2018.00095","journal-title":"Front Physiol"},{"issue":"1","key":"2503_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s12264-020-00569-5","volume":"37","author":"M Shibata","year":"2021","unstructured":"Shibata M, Tang C (2021) Implications of transient receptor potential cation channels in migraine pathophysiology. Neurosci Bull 37(1):103\u2013116. https:\/\/doi.org\/10.1007\/s12264-020-00569-5","journal-title":"Neurosci Bull"},{"issue":"1","key":"2503_CR15","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/S1097-2765(01)00438-5","volume":"9","author":"Y Hara","year":"2002","unstructured":"Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T et al (2002) LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9(1):163\u2013173. https:\/\/doi.org\/10.1016\/S1097-2765(01)00438-5","journal-title":"Mol Cell"},{"issue":"1\u20132","key":"2503_CR16","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jns.2008.03.003","volume":"270","author":"M Naz\u0131ro\u011flu","year":"2008","unstructured":"Naz\u0131ro\u011flu M, L\u00fcckhoff A (2008) Effects of antioxidants on calcium influx through TRPM2 channels in transfected cells activated by hydrogen peroxide. J Neurol Sci 270(1\u20132):152\u2013158. https:\/\/doi.org\/10.1016\/j.jns.2008.03.003","journal-title":"J Neurol Sci"},{"key":"2503_CR17","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.neuroscience.2015.03.067","volume":"297","author":"MK Chung","year":"2015","unstructured":"Chung MK, Asgar J, Lee J, Shim MS, Dumler C, Ro JY (2015) The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia. Neuroscience 297:160\u2013169. https:\/\/doi.org\/10.1016\/j.neuroscience.2015.03.067","journal-title":"Neuroscience"},{"issue":"2","key":"2503_CR18","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s00232-011-9363-9","volume":"241","author":"M Naz\u0131ro\u011flu","year":"2011","unstructured":"Naz\u0131ro\u011flu M, \u00d6zg\u00fcl C, \u00c7elik \u00d6, \u00c7i\u011f B, S\u00f6zbir E (2011) Aminoethoxydiphenyl borate and flufenamic acid inhibit Ca2+ influx through TRPM2 channels in rat dorsal root ganglion neurons activated by ADP-ribose and rotenone. J Membr Biol 241(2):69\u201375. https:\/\/doi.org\/10.1007\/s00232-011-9363-9","journal-title":"J Membr Biol"},{"issue":"1","key":"2503_CR19","doi-asserted-by":"publisher","first-page":"17543","DOI":"10.1038\/s41598-017-17715-1","volume":"7","author":"E Y\u00fcksel","year":"2017","unstructured":"Y\u00fcksel E, Naz\u0131ro\u011flu M, \u015eahin M, \u00c7i\u011f B (2017) Involvement of TRPM2 and TRPV1 channels on hyperalgesia, apoptosis and oxidative stress in rat fibromyalgia model: Protective role of selenium. Sci Rep 7(1):17543. https:\/\/doi.org\/10.1038\/s41598-017-17715-1","journal-title":"Sci Rep"},{"key":"2503_CR20","doi-asserted-by":"publisher","first-page":"335","DOI":"10.3389\/fphys.2017.00335","volume":"8","author":"F Uslusoy","year":"2017","unstructured":"Uslusoy F, Naz\u0131ro\u011flu M, \u00c7i\u011f B (2017) Inhibition of the TRPM2 and TRPV1 channels through Hypericum perforatum in sciatic nerve injury-induced rats demonstrates their key role in apoptosis and mitochondrial oxidative stress of sciatic nerve and dorsal Root ganglion. Front Physiol 8:335. https:\/\/doi.org\/10.3389\/fphys.2017.00335","journal-title":"Front Physiol"},{"key":"2503_CR21","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3389\/fncel.2017.00226","volume":"11","author":"K Koroleva","year":"2017","unstructured":"Koroleva K, Mustafina A, Yakovlev A, Hermann A, Giniatullin R, Sitdikova G (2017) Receptor mechanisms mediating the pro-nociceptive action of hydrogen sulfide in rat trigeminal neurons and meningeal afferents. Front Cell Neurosci 11:226. https:\/\/doi.org\/10.3389\/fncel.2017.00226","journal-title":"Front Cell Neurosci"},{"issue":"11","key":"2503_CR22","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1002\/ar.23475","volume":"299","author":"MC Rusu","year":"2016","unstructured":"Rusu MC, M\u0103noiu VS, Vrapciu AD, Hostiuc S, Mirancea N (2016) Altered mitochondrial anatomy of trigeminal ganglia neurons in diabetes. Anat Rec (Hoboken) 299(11):1561\u20131570. https:\/\/doi.org\/10.1002\/ar.23475","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"2503_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF03033363","volume":"13","author":"B Bawa","year":"2008","unstructured":"Bawa B, Abbott LC (2008) Analysis of calcium ion homeostasis and mitochondrial function in cerebellar granule cells of adult CaV 2.1 calcium ion channel mutant mice. Neurotox Res 13(1):1\u201318. https:\/\/doi.org\/10.1007\/BF03033363","journal-title":"Neurotox Res"},{"issue":"4","key":"2503_CR24","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.ceca.2006.08.014","volume":"41","author":"TD Gover","year":"2007","unstructured":"Gover TD, Moreira TH, Kao JP, Weinreich D (2007) Calcium homeostasis in trigeminal ganglion cell bodies. Cell Calcium 41(4):389\u2013396. https:\/\/doi.org\/10.1016\/j.ceca.2006.08.014","journal-title":"Cell Calcium"},{"key":"2503_CR25","doi-asserted-by":"publisher","first-page":"2054","DOI":"10.1016\/j.bbamcr.2016.05.007","volume":"8","author":"L Pecze","year":"1863","unstructured":"Pecze L, J\u00f3svay K, Blum W, Petrovics G, Vizler C, Ol\u00e1h Z, Schwaller B (1863) (2016) Activation of endogenous TRPV1 fails to induce overstimulation-based cytotoxicity in breast and prostate cancer cells but not in pain-sensing neurons. Biochim Biophys Acta 8:2054\u20132064. https:\/\/doi.org\/10.1016\/j.bbamcr.2016.05.007","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"2503_CR26","doi-asserted-by":"publisher","first-page":"4543","DOI":"10.1038\/s41598-021-84102-2","volume":"11","author":"EC Gross","year":"2021","unstructured":"Gross EC, Putananickal N, Orsini AL, Vogt DR, Sandor PS, Schoenen J, Fischer D (2021) Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine. Sci Rep 11(1):4543. https:\/\/doi.org\/10.1038\/s41598-021-84102-2","journal-title":"Sci Rep"},{"issue":"3","key":"2503_CR27","doi-asserted-by":"publisher","first-page":"3822","DOI":"10.1002\/jcb.27664","volume":"120","author":"M \u00c7ak\u0131r","year":"2019","unstructured":"\u00c7ak\u0131r M, Tekin S, Ta\u015fl\u0131dere A, \u00c7akan P, D\u00fczova H, G\u00fcl CC (2019) Protective effect of N-(p-amylcinnamoyl) anthranilic acid, phospholipase A2 enzyme inhibitor, and transient receptor potential melastatin-2 channel blocker against renal ischemia-reperfusion injury. J Cell Biochem 120(3):3822\u20133832. https:\/\/doi.org\/10.1002\/jcb.27664","journal-title":"J Cell Biochem"},{"issue":"3","key":"2503_CR28","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1124\/jpet.109.157677","volume":"331","author":"MJ Wacker","year":"2009","unstructured":"Wacker MJ, Kosloski LM, Gilbert WJ, Touchberry CD, Moore DS, Kelly JK, Brotto M, Orr JA (2009) Inhibition of thromboxane A2-induced arrhythmias and intracellular calcium changes in cardiac myocytes by blockade of the inositol trisphosphate pathway. J Pharmacol Exp Ther 331(3):917\u2013924. https:\/\/doi.org\/10.1124\/jpet.109.157677","journal-title":"J Pharmacol Exp Ther"},{"issue":"3","key":"2503_CR29","first-page":"544","volume":"53","author":"FP Hamers","year":"1993","unstructured":"Hamers FP, Brakkee JH, Cavalletti E, Tedeschi M, Marmonti L, Pezzoni G, Neijt JP, Gispen WH (1993) Reduced glutathione protects against cisplatin-induced neurotoxicity in rats. Cancer Res 53(3):544\u2013549","journal-title":"Cancer Res"},{"issue":"490","key":"2503_CR30","doi-asserted-by":"publisher","first-page":"eaal4161","DOI":"10.1126\/scisignal.aal4161","volume":"10","author":"N Abuarab","year":"2017","unstructured":"Abuarab N, Munsey TS, Jiang LH, Li J, Sivaprasadarao A (2017) High glucose-induced ROS activates TRPM2 to trigger lysosomal membrane permeabilization and Zn2+-mediated mitochondrial fission. Sci Signal 10(490):eaal4161. https:\/\/doi.org\/10.1126\/scisignal.aal4161","journal-title":"Sci Signal"},{"issue":"1","key":"2503_CR31","doi-asserted-by":"publisher","first-page":"12403","DOI":"10.1038\/s41598-019-48716-x","volume":"9","author":"M Naz\u0131ro\u011flu","year":"2019","unstructured":"Naz\u0131ro\u011flu M, \u00c7i\u011f B, Yaz\u011fan Y, Schwaerzer GK, Theilig F, Pecze L (2019) Albumin evokes Ca2+-induced cell oxidative stress and apoptosis through TRPM2 channel in renal collecting duct cells reduced by curcumin. Sci Rep 9(1):12403. https:\/\/doi.org\/10.1038\/s41598-019-48716-x","journal-title":"Sci Rep"},{"issue":"1","key":"2503_CR32","doi-asserted-by":"publisher","first-page":"815","DOI":"10.37212\/jcnos.653500","volume":"11","author":"K Ertilav","year":"2019","unstructured":"Ertilav K (2019) Pregabalin protected cisplatin-induced oxidative neurotoxicity in neuronal cell line. J Cell Neurosci Oxid Stress 11(1):815\u2013824","journal-title":"J Cell Neurosci Oxid Stress"},{"issue":"8","key":"2503_CR33","doi-asserted-by":"publisher","first-page":"3508","DOI":"10.1007\/s12035-020-01974-7","volume":"57","author":"K Y\u0131ld\u0131zhan","year":"2020","unstructured":"Y\u0131ld\u0131zhan K, Naz\u0131ro\u011flu M (2020) Glutathione depletion and parkinsonian neurotoxin MPP+-induced TRPM2 channel activation play central roles in oxidative cytotoxicity and inflammation in microglia. Mol Neurobiol 57(8):3508\u20133525. https:\/\/doi.org\/10.1007\/s12035-020-01974-7","journal-title":"Mol Neurobiol"},{"issue":"51","key":"2503_CR34","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.3791\/2704","volume":"23","author":"DC Joshi","year":"2011","unstructured":"Joshi DC, Bakowska JC (2011) Determination of mitochondrial membrane potential and reactive oxygen species in live rat cortical neurons. J Vis Exp 23(51):2704. https:\/\/doi.org\/10.3791\/2704","journal-title":"J Vis Exp"},{"key":"2503_CR35","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1007\/s00424-011-1012-8","volume":"462","author":"VC Keil","year":"2011","unstructured":"Keil VC, Funke F, Zeug A, Schild D, M\u00fcller M (2011) Ratiometric high-resolution imaging of JC-1 fluorescence reveals the subcellular heterogeneity of astrocytic mitochondria. Pflugers Arch 462:693\u2013708. https:\/\/doi.org\/10.1007\/s00424-011-1012-8","journal-title":"Pflugers Arch"},{"key":"2503_CR36","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.neuroscience.2014.09.078","volume":"284","author":"IS \u00d6vey","year":"2015","unstructured":"\u00d6vey IS, Naz\u0131ro\u011flu M (2015) Homocysteine and cytosolic GSH depletion induce apoptosis and oxidative toxicity through cytosolic calcium overload in the hippocampus of aged mice: involvement of TRPM2 and TRPV1 channels. Neuroscience 284:225\u2013233. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.09.078","journal-title":"Neuroscience"},{"key":"2503_CR37","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1756-6606-5-11","volume":"5","author":"JC Belrose","year":"2012","unstructured":"Belrose JC, Xie YF, Gierszewski LJ, MacDonald JF, Jackson MF (2012) Loss of glutathione homeostasis associated with neuronal senescence facilitates TRPM2 channel activation in cultured hippocampal pyramidal neurons. Mol Brain 5:11. https:\/\/doi.org\/10.1186\/1756-6606-5-11","journal-title":"Mol Brain"},{"issue":"2","key":"2503_CR38","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.physbeh.2012.01.014","volume":"106","author":"C \u00d6zg\u00fcl","year":"2012","unstructured":"\u00d6zg\u00fcl C, Naz\u0131ro\u011flu M (2012) TRPM2 channel protective properties of N-acetylcysteine on cytosolic glutathione depletion dependent oxidative stress and Ca2+ influx in rat dorsal root ganglion. Physiol Behav 106(2):122\u2013128. https:\/\/doi.org\/10.1016\/j.physbeh.2012.01.014","journal-title":"Physiol Behav"},{"issue":"3","key":"2503_CR39","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s00232-011-9382-6","volume":"242","author":"M Naz\u0131ro\u011flu","year":"2011","unstructured":"Naz\u0131ro\u011flu M, \u00d6zg\u00fcl C, \u00c7i\u011f B, Do\u011fan S, U\u011fuz AC (2011) Glutathione modulates Ca(2+) influx and oxidative toxicity through TRPM2 channel in rat dorsal root ganglion neurons. J Membr Biol 242(3):109\u2013118. https:\/\/doi.org\/10.1007\/s00232-011-9382-6","journal-title":"J Membr Biol"},{"issue":"7","key":"2503_CR40","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1096\/fj.09-149997","volume":"24","author":"M Lee","year":"2010","unstructured":"Lee M, Cho T, Jantaratnotai N, Wang YT, McGeer E, McGeer PL (2010) Depletion of GSH in glial cells induces neurotoxicity: relevance to aging and degenerative neurological diseases. FASEB J 24(7):2533\u20132545. https:\/\/doi.org\/10.1096\/fj.09-149997","journal-title":"FASEB J"},{"issue":"6","key":"2503_CR41","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1111\/jnc.14308","volume":"144","author":"J Zhang","year":"2018","unstructured":"Zhang J, Culp ML, Craver JG, Darley-Usmar V (2018) Mitochondrial function and autophagy: integrating proteotoxic, redox, and metabolic stress in Parkinson\u2019s disease. J Neurochem 144(6):691\u2013709. https:\/\/doi.org\/10.1111\/jnc.14308","journal-title":"J Neurochem"},{"key":"2503_CR42","doi-asserted-by":"publisher","first-page":"45032","DOI":"10.1038\/srep45032","volume":"7","author":"SS Mortadza","year":"2017","unstructured":"Mortadza SS, Sim JA, Stacey M, Jiang LH (2017) Signalling mechanisms mediating Zn(2+)-induced TRPM2 channel activation and cell death in microglial cells. Sci Rep 7:45032. https:\/\/doi.org\/10.1038\/srep45032","journal-title":"Sci Rep"},{"issue":"6","key":"2503_CR43","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/j.molimm.2004.09.019","volume":"42","author":"ME Moreno-Garc\u00eda","year":"2005","unstructured":"Moreno-Garc\u00eda ME, Sumoza-Toledo A, Lund FE, Santos-Argumedo L (2005) Localization of CD38 in murine B lymphocytes to plasma but not intracellular membranes. Mol Immunol 42(6):703\u2013711. https:\/\/doi.org\/10.1016\/j.molimm.2004.09.019","journal-title":"Mol Immunol"},{"issue":"10","key":"2503_CR44","doi-asserted-by":"publisher","first-page":"1987","DOI":"10.1007\/s00424-013-1436-4","volume":"466","author":"Y Jang","year":"2014","unstructured":"Jang Y, Lee MH, Lee J, Jung J, Lee SH, Yang DJ, Kim BW, Son H et al (2014) TRPM2 mediates the lysophosphatidic acid-induced neurite retraction in the developing brain. Pflugers Arch 466(10):1987\u20131998. https:\/\/doi.org\/10.1007\/s00424-013-1436-4","journal-title":"Pflugers Arch"},{"issue":"1","key":"2503_CR45","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1186\/s12883-019-1555-4","volume":"19","author":"M Togha","year":"2019","unstructured":"Togha M, Razeghi Jahromi S, Ghorbani Z, Ghaemi A, Rafiee P (2019) An investigation of oxidant\/antioxidant balance in patients with migraine: a case-control study. BMC Neurol 19(1):323. https:\/\/doi.org\/10.1186\/s12883-019-1555-4","journal-title":"BMC Neurol"},{"issue":"4","key":"2503_CR46","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1080\/00207454.2017.1374959","volume":"128","author":"GM Tripathi","year":"2018","unstructured":"Tripathi GM, Kalita J, Misra UK (2018) A study of oxidative stress in migraine with special reference to prophylactic therapy. Int J Neurosci 128(4):318\u2013324. https:\/\/doi.org\/10.1080\/00207454.2017.1374959","journal-title":"Int J Neurosci"},{"issue":"6","key":"2503_CR47","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/cells8060564","volume":"8","author":"JC Chang","year":"2019","unstructured":"Chang JC, Lien CF, Lee WS, Chang HR, Hsu YC, Luo YP, Jeng JR, Hsieh JC, Yang KT (2019) Intermittent hypoxia prevents myocardial mitochondrial Ca2+ overload and cell death during ischemia\/reperfusion: The role of reactive oxygen species. Cells 8(6):564. https:\/\/doi.org\/10.3390\/cells8060564","journal-title":"Cells"},{"issue":"2","key":"2503_CR48","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1111\/j.1600-079X.2011.00876.x","volume":"51","author":"J Espino","year":"2011","unstructured":"Espino J, Bejarano I, Paredes SD, Barriga C, Rodr\u00edguez AB, Pariente JA (2011) Protective effect of melatonin against human leukocyte apoptosis induced by intracellular calcium overload: relation with its antioxidant actions. J Pineal Res 51(2):195\u2013206. https:\/\/doi.org\/10.1111\/j.1600-079X.2011.00876.x","journal-title":"J Pineal Res"},{"key":"2503_CR49","doi-asserted-by":"publisher","unstructured":"Naz\u0131ro\u011flu M, \u00d6z A, Y\u0131ld\u0131zhan K (2020) Selenium and neurological diseases: focus on peripheral pain and TRP channels. Curr Neuropharmacol 18(6):501\u2013517. https:\/\/doi.org\/10.2174\/1570159X18666200106152631","DOI":"10.2174\/1570159X18666200106152631"},{"issue":"11","key":"2503_CR50","doi-asserted-by":"publisher","first-page":"1990","DOI":"10.1007\/s11064-007-9386-x","volume":"32","author":"M Naz\u0131ro\u011flu","year":"2007","unstructured":"Naz\u0131ro\u011flu M (2007) New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose. Neurochem Res 32(11):1990\u20132001","journal-title":"Neurochem Res"},{"issue":"6837","key":"2503_CR51","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/35079100","volume":"411","author":"AL Perraud","year":"2011","unstructured":"Perraud AL, Fleig A, Dunn CA, Bagley LA, Launay P, Schmitz C, Stokes AJ, Zhu Q et al (2011) ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology. Nature 411(6837):595\u2013599. https:\/\/doi.org\/10.1038\/35079100","journal-title":"Nature"},{"issue":"3","key":"2503_CR52","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/sj.bjp.0706739","volume":"148","author":"R Kraft","year":"2006","unstructured":"Kraft R, Grimm C, Frenzel H, Harteneck C (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol 148(3):264\u2013273","journal-title":"Br J Pharmacol"},{"issue":"6","key":"2503_CR53","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1038\/sj.bjp.0707675","volume":"153","author":"K Togashi","year":"2008","unstructured":"Togashi K, Inada H, Tominaga M (2008) Inhibition of the transient receptor potential cation channel TRPM2 by 2-aminoethoxydiphenyl borate (2-APB). Br J Pharmacol 153(6):1324\u20131330. https:\/\/doi.org\/10.1038\/sj.bjp.0707675","journal-title":"Br J Pharmacol"},{"key":"2503_CR54","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.toxlet.2019.10.014","volume":"319","author":"MA Vitoux","year":"2020","unstructured":"Vitoux MA, Kessal K, Melik Parsadaniantz S, Claret M, Guerin C, Baudouin C, Brignole-Baudouin F, R\u00e9aux-Le GA (2020) Benzalkonium chloride-induced direct and indirect toxicity on corneal epithelial and trigeminal neuronal cells: proinflammatory and apoptotic responses in vitro. Toxicol Lett 319:74\u201384. https:\/\/doi.org\/10.1016\/j.toxlet.2019.10.014","journal-title":"Toxicol Lett"},{"key":"2503_CR55","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000002214","author":"T Yamamoto","year":"2021","unstructured":"Yamamoto T, Mulpuri Y, Izraylev M, Li Q, Simonian M, Kramme C, Schmidt BL, Seltzman HH, Spigelman I (2021 Jan 29) (2021) Selective targeting of peripheral cannabinoid receptors prevents behavioral symptoms and sensitization of trigeminal neurons in mouse models of migraine and medication overuse headache. Pain. https:\/\/doi.org\/10.1097\/j.pain.0000000000002214","journal-title":"Pain"},{"key":"2503_CR56","doi-asserted-by":"publisher","first-page":"2413919","DOI":"10.1155\/2019\/2413919","volume":"2019","author":"CC Liao","year":"2019","unstructured":"Liao CC, Li JM, Hsieh CL (2019) Auricular electrical stimulation alleviates headache through CGRP\/COX-2\/TRPV1\/TRPA1 signaling pathways in a nitroglycerin-induced migraine rat model. Evid Based Complement Alternat Med 2019:2413919. https:\/\/doi.org\/10.1155\/2019\/2413919","journal-title":"Evid Based Complement Alternat Med"},{"key":"2503_CR57","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.freeradbiomed.2019.12.016","volume":"147","author":"A Morii","year":"2020","unstructured":"Morii A, Miyamura Y, Sago MI, Mizuhara M, Shikayama T, Naniwa M, Hitomi S, Ujihara I et al (2020) Orthodontic force-induced oxidative stress in the periodontal tissue and dental pulp elicits nociception via activation\/sensitization of TRPA1 on nociceptive fibers. Free Radic Biol Med 147:175\u2013186. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.12.016","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"2503_CR58","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1080\/00207454.2019.1681994","volume":"130","author":"Z Karaaslan","year":"2020","unstructured":"Karaaslan Z, \u00d6z\u00e7elik P, Ulukan \u00c7, Ulusoy C, Orhan KS, Orhan EK et al (2020) Plasma levels of inflammatory mediators in vestibular migraine. Int J Neurosci 130(4):330\u2013335. https:\/\/doi.org\/10.1080\/00207454.2019.1681994","journal-title":"Int J Neurosci"},{"issue":"1","key":"2503_CR59","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052394","volume":"8","author":"A Franceschini","year":"2013","unstructured":"Franceschini A, Vilotti S, Ferrari MD, van den Maagdenberg AM, Nistri A, Fabbretti E (2013) TNF\u03b1 levels and macrophages expression reflect an inflammatory potential of trigeminal ganglia in a mouse model of familial hemiplegic migraine. PLoS ONE 8(1):e52394. https:\/\/doi.org\/10.1371\/journal.pone.0052394","journal-title":"PLoS ONE"},{"issue":"31","key":"2503_CR60","doi-asserted-by":"publisher","first-page":"50708","DOI":"10.18632\/oncotarget.9367","volume":"7","author":"M Kowalska","year":"2016","unstructured":"Kowalska M, Prendecki M, Kozubski W, Lianeri M, Dorszewska J (2016) Molecular factors in migraine. Oncotarget 7(31):50708\u201350718. https:\/\/doi.org\/10.18632\/oncotarget.9367","journal-title":"Oncotarget"},{"key":"2503_CR61","doi-asserted-by":"publisher","unstructured":"G\u00fczel M, Naz\u0131ro\u011flu M, Akp\u0131nar O, \u00c7\u0131nar R. (2021) Interferon gamma-mediated oxidative stress induces apoptosis, neuroinflammation, zinc ion influx, and TRPM2 channel activation in neuronal cell line: Modulator role of curcumin. inflammation. 2021 Apr 17. Epub ahead of print.\u00a0https:\/\/doi.org\/10.1007\/s10753-021-01465-4.","DOI":"10.1007\/s10753-021-01465-4"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02503-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-021-02503-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-021-02503-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T20:17:45Z","timestamp":1637180265000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-021-02503-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":61,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["2503"],"URL":"https:\/\/doi.org\/10.1007\/s12035-021-02503-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"assertion":[{"value":"17 June 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 July 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors. The present study was performed with the approval of the Experimental Animal Ethics Committee of Burdur Mehmet Akif University (Number: 2019\u2013602. Date: 18.12.2019). The authors have no ethical conflicts to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Dr. Naz\u0131ro\u011flu reviewed the current literature, and designed the project. Mr. Y Yaz\u011fan performed animal care, patch clamp, and spectrofluorometer tests. Dr. Naz\u0131ro\u011flu conceptualized this perspective piece, reviewed and revised the manuscript. All authors approved the final manuscript as submitted.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors approved the final manuscript as submitted.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors have no conflicts of interest to declare.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}