{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T04:23:02Z","timestamp":1772511782787,"version":"3.50.1"},"reference-count":69,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["grant nr UMO 2014\/13\/D\/NZ5\/03337."],"award-info":[{"award-number":["grant nr UMO 2014\/13\/D\/NZ5\/03337."]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Because of vast variability of cochlear implantation outcomes in prelingual deafness treatment, identification of good and poor performers remains a challenging task. To address this issue, we investigated genetic variants of matrix metalloproteinase 9 (\n                    <jats:italic>MMP9<\/jats:italic>\n                    ) and brain-derived neurotrophic factor (\n                    <jats:italic>BDNF<\/jats:italic>\n                    ) and plasma levels of MMP-9, BDNF, and pro-BDNF that have all been implicated in neuroplasticity after sensory deprivation in the auditory pathway. We recruited a cohort of prelingually deaf children, all implanted before the age of 2, and carried out a prospective observation (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200961). Next, we analyzed the association between (i) functional\n                    <jats:italic>MMP9<\/jats:italic>\n                    (rs20544, rs3918242, rs2234681) and\n                    <jats:italic>BDNF<\/jats:italic>\n                    (rs6265) gene variants (and their respective protein levels) and (ii) the child\u2019s auditory development as measured with the LittlEARS Questionnaire (LEAQ) before cochlear implant (CI) activation and at 8 and 18\u00a0months post-CI activation. Statistical analyses revealed that the plasma level of MMP-9 measured at implantation in prelingually deaf children was significantly correlated with the LEAQ score 18\u00a0months after CI activation. In the subgroup of DFNB1-related deafness (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200940), rs3918242 of\n                    <jats:italic>MMP9<\/jats:italic>\n                    was significantly associated with LEAQ score at 18\u00a0months after CI activation; also, according to a multiple regression model, the ratio of plasma levels of pro-BDNF\/BDNF measured at implantation was a significant predictor of overall LEAQ score at follow-up. In the subgroup with DFNB1-related deafness, who had CI activation after 1\u00a0year old (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u200922), a multiple regression model showed that rs3918242 of\n                    <jats:italic>MMP9<\/jats:italic>\n                    was a significant predictor of overall LEAQ score at follow-up.\n                  <\/jats:p>","DOI":"10.1007\/s12035-022-02732-7","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T01:04:25Z","timestamp":1642727065000},"page":"2190-2203","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Prospective cohort study reveals MMP-9, a neuroplasticity regulator, as a prediction marker of cochlear implantation outcome in prelingual deafness treatment"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1138-3425","authenticated-orcid":false,"given":"Monika","family":"Matusiak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-8002","authenticated-orcid":false,"given":"Dominika","family":"Ozi\u0119b\u0142o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4216-9141","authenticated-orcid":false,"given":"Monika","family":"O\u0142dak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-5316","authenticated-orcid":false,"given":"Emilia","family":"Rejmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-3490","authenticated-orcid":false,"given":"Leszek","family":"Kaczmarek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-1915","authenticated-orcid":false,"given":"Piotr Henryk","family":"Skar\u017cy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7141-9851","authenticated-orcid":false,"given":"Henryk","family":"Skar\u017cy\u0144ski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"issue":"6","key":"2732_CR1","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1016\/S1474-4422(16)00034-X","volume":"15","author":"A Kral","year":"2016","unstructured":"Kral A, Kronenberger WG, Pisoni DB, O\u2019Donoghue GM (2016) Neurocognitive factors in sensory restoration of early deafness: a connectome model. Lancet Neurolol 15(6):610\u2013621. https:\/\/doi.org\/10.1016\/S1474-4422(16)00034-X","journal-title":"Lancet Neurolol"},{"key":"2732_CR2","doi-asserted-by":"publisher","unstructured":"Niparko et al. (2010)\u00a0Spoken language development in children following cochlear implantation JAMA. 303(15):1498\u20131506.\u00a0https:\/\/doi.org\/10.1001\/jama.2010.451","DOI":"10.1001\/jama.2010.451"},{"issue":"8","key":"2732_CR3","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/MAO.0b013e3181f1cde3","volume":"31","author":"L De Raeve","year":"2010","unstructured":"De Raeve L (2010) A longitudinal study on auditory perception and speech intelligibility in deaf children implanted younger than 18 months in comparison to those implanted at later ages. Otol Neurotol 31(8):261\u2013267. https:\/\/doi.org\/10.1097\/MAO.0b013e3181f1cde3","journal-title":"Otol Neurotol"},{"issue":"6","key":"2732_CR4","doi-asserted-by":"publisher","first-page":"065008","DOI":"10.1088\/1741-2560\/6\/6\/065008","volume":"6","author":"JB Fallon","year":"2009","unstructured":"Fallon JB, Irvine DRF, Shepherd RK (2009) Neural prostheses and brain plasticity. J Neural Eng 6(6):065008. https:\/\/doi.org\/10.1088\/1741-2560\/6\/6\/065008","journal-title":"J Neural Eng"},{"key":"2732_CR5","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1111\/j.1467-7687.2012.01140.x","volume":"15","author":"DM Houston","year":"2012","unstructured":"Houston DM, Stewart J, Moberly A, Hollich G, Miyamoto RT (2012) Word learning in deaf children with cochlear implants: effects of early auditory experience. Dev Sci 15:448\u2013461. https:\/\/doi.org\/10.1111\/j.1467-7687.2012.01140.x","journal-title":"Dev Sci"},{"issue":"1","key":"2732_CR6","doi-asserted-by":"publisher","first-page":"228","DOI":"10.3390\/jcm9010228","volume":"9","author":"D Ozi\u0119b\u0142o","year":"2020","unstructured":"Ozi\u0119b\u0142o D, Obrycka A, Lorens A, Skar\u017cy\u0144ski H, O\u0142dak M (2020) Cochlear implantation outcome in children with DFNB1 locus pathogenic variants. J Clin Med 9(1):228. https:\/\/doi.org\/10.3390\/jcm9010228","journal-title":"J Clin Med"},{"issue":"1","key":"2732_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1177\/0194599817697054","volume":"157","author":"Y Abdurehim","year":"2017","unstructured":"Abdurehim Y, Lehmann A, Zeitouni AG (2017) Predictive value of GJB2 mutation status for hearing outcomes of pediatric cochlear implantation. Otolaryngol Head Neck Surg 157(1):16\u201324. https:\/\/doi.org\/10.1177\/0194599817697054","journal-title":"Otolaryngol Head Neck Surg"},{"key":"2732_CR8","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.heares.2017.02.008","volume":"348","author":"AE Shearer","year":"2017","unstructured":"Shearer AE, Eppsteiner RW, Frees K, Tejani V, Sloan-Heggen CM, Brown C, Abbas P, Dunn C, et al. (2017) Genetic variants in the peripheral auditory system significantly affect adult cochlear implant performance. Hear Res 348:138\u2013142. https:\/\/doi.org\/10.1016\/j.heares.2017.02.008","journal-title":"Hear Res"},{"issue":"5","key":"2732_CR9","doi-asserted-by":"publisher","first-page":"e316","DOI":"10.1097\/AUD.0000000000000437","volume":"38","author":"JH Park","year":"2017","unstructured":"Park JH, Kim AR, Han JH, Kim SD, Kim SH, Koo J-W, Oh SH, Choi BY (2017) Outcome of cochlear implantation in prelingually deafened children according to molecular genetic etiology. Ear Hear 38(5):e316\u2013e324. https:\/\/doi.org\/10.1097\/AUD.0000000000000437","journal-title":"Ear Hear"},{"issue":"7","key":"2732_CR10","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/j.ijporl.2010.04.002","volume":"74","author":"J Reinert","year":"2010","unstructured":"Reinert J, Honegger F, Gurtler N (2010) High homogeneity in auditory outcome of pediatric CI-patients with mutations in Gap-Junction-Protein Beta2. Intl J Pediatr Otorhinolaryngol 74(7):791\u2013795. https:\/\/doi.org\/10.1016\/j.ijporl.2010.04.002","journal-title":"Intl J Pediatr Otorhinolaryngol"},{"issue":"1\u20132","key":"2732_CR11","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.heares.2012.08.007","volume":"292","author":"RW Eppsteiner","year":"2012","unstructured":"Eppsteiner RW, Shearer AE, Hilderbrand MS, DeLuca AP, Haihong J, Dunn CC, Black-Ziegelbein EA, et al. (2012) Prediction of cochlear implant performance by genetic mutation: the spiral ganglion hypothesis. Hear Res. 292(1\u20132):51\u201358. https:\/\/doi.org\/10.1016\/j.heares.2012.08.007","journal-title":"Hear Res."},{"key":"2732_CR12","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1097\/mao.0b013e31823387f9","volume":"32","author":"SI Angeli","year":"2011","unstructured":"Angeli SI, Suarez H, Lopez H, Balkany T, Liu XZ (2011) Influence on DFNB1 status on expressive language in deaf children with cochlear implants. Otol Neurotol 32:1437\u20131443. https:\/\/doi.org\/10.1097\/mao.0b013e31823387f9","journal-title":"Otol Neurotol"},{"key":"2732_CR13","unstructured":"Smith RJH, Jones MKN (1998). Nonsyndromic Hearing Loss and Deafness, DFNB1. Sep 28 [Updated 2016 Aug 18]. In: Adam MP, Ardinger HH, Pagon RA, et al., editors. GeneReviews\u00ae [Internet]. Seattle (WA): University of Washington, Seattle; 1993\u20132021.\u00a0Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK1272\/"},{"key":"2732_CR14","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.bbrc.2014.04.016","volume":"448","author":"J Chen","year":"2014","unstructured":"Chen J, Chen J, Zhu Y, Liang C, Zhao HB (2014) Deafness induced by Connexin 26 (GJB2) deficiency is not determined by endocochlear potential (EP) reduction but is associated with cochlear developmental disorders. Biochem Biophys Res Commun 448:28\u201332. https:\/\/doi.org\/10.1016\/j.bbrc.2014.04.016","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"2732_CR15","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1007\/s007950070001","volume":"33","author":"T Kikuchi","year":"2000","unstructured":"Kikuchi T, Adams JC, Miyabe Y, So E, Kobayashi T (2000) Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness. Med Electron Microsc 33(2):51\u201356. https:\/\/doi.org\/10.1007\/s007950070001","journal-title":"Med Electron Microsc"},{"key":"2732_CR16","doi-asserted-by":"publisher","first-page":"909","DOI":"10.1093\/cercor\/bh1001","volume":"17","author":"H-J Lee","year":"2007","unstructured":"Lee H-J, Giraud A-L, Kang E, Oh S-H, Kang H, Kim C-S, Lee D-S (2007) Cortical activity at rest predicts cochlear implantation outcome. Cereb Cortex 17:909\u2013917. https:\/\/doi.org\/10.1093\/cercor\/bh1001","journal-title":"Cereb Cortex"},{"issue":"16","key":"2732_CR17","doi-asserted-by":"publisher","first-page":"3207","DOI":"10.1007\/s00018-019-03180-8","volume":"76","author":"A Beroun","year":"2019","unstructured":"Beroun A, Mitra S, Michaluk P, Pijet B, Stefaniuk M, Kaczmarek L (2019) MMPs in learning and memory and neuropsychiatric disorders. Cell Mol Life Sci 76(16):3207\u20133228. https:\/\/doi.org\/10.1007\/s00018-019-03180-8","journal-title":"Cell Mol Life Sci"},{"issue":"Suppl 2","key":"2732_CR18","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1111\/jnc.13415","volume":"139","author":"B Vafadari","year":"2016","unstructured":"Vafadari B, Salamian A, Kaczmarek L (2016) MMP-9 in translation: from molecule to brain physiology, pathology, and therapy. J Neurochem 139(Suppl 2):91\u2013114. https:\/\/doi.org\/10.1111\/jnc.13415","journal-title":"J Neurochem"},{"key":"2732_CR19","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.psychres.2018.01.044","volume":"262","author":"N McGregor","year":"2018","unstructured":"McGregor N, Thompson N, O\u2019Connell KS, Emsley R, van der Merwe L, Warnich L (2018) Modification of the association between antipsychotic treatment response and childhood adversity by MMP9 gene and its variants in a first-episode schizophrenia cohort. Psychiatry Res 262:141\u2013148. https:\/\/doi.org\/10.1016\/j.psychres.2018.01.044","journal-title":"Psychiatry Res"},{"key":"2732_CR20","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3389\/fncel.2015.00280","volume":"9","author":"SM Reinhard","year":"2015","unstructured":"Reinhard SM, Razak K, Ethell I (2015) A delicate balance: role of MMP9 in brain development and pathophysiology of neurodevelopmental disorders. Front Cell Neurosci 9:280. https:\/\/doi.org\/10.3389\/fncel.2015.00280","journal-title":"Front Cell Neurosci"},{"issue":"46","key":"2732_CR21","doi-asserted-by":"publisher","first-page":"15337","DOI":"10.1523\/jneurosci.3467-10.2010","volume":"30","author":"S Rivera","year":"2010","unstructured":"Rivera S, Khrestchaitsky M, Kaczmarek L, Rosenberg G, Jaworski DM (2010) Metzincin proteases and their inhibitors: foes and friends in nervous system physiology? J Neurosci 30(46):15337\u201315357. https:\/\/doi.org\/10.1523\/jneurosci.3467-10.2010","journal-title":"J Neurosci"},{"issue":"3","key":"2732_CR22","doi-asserted-by":"publisher","first-page":"222","DOI":"10.3109\/10409238.2013.770819","volume":"48","author":"J Vandooren","year":"2013","unstructured":"Vandooren J, Van den Steen PE, Opdenakker G (2013) Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decade. Crit Rev Biochem Mol Biol 48(3):222\u2013272. https:\/\/doi.org\/10.3109\/10409238.2013.770819","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"13","key":"2732_CR23","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1002\/jnr.21273","volume":"85","author":"IM Ethel","year":"2007","unstructured":"Ethel IM, Ethel DW (2007) Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J Neurosci Res 85(13):2813\u20132823. https:\/\/doi.org\/10.1002\/jnr.21273","journal-title":"J Neurosci Res"},{"issue":"7","key":"2732_CR24","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1523\/jneurosci.4359-05.2006","volume":"26","author":"V Nagy","year":"2006","unstructured":"Nagy V, Bozdagy O, Matynia A, Balcerzak M, Okulski P, Dzwonek J, Costa RM, Silva AJ, et al. (2006) Matrix metalloproteinase-9 is required for hippocampal late-phase long-term potentiation and memory. J Neurosci 26(7):1923\u20131934. https:\/\/doi.org\/10.1523\/jneurosci.4359-05.2006","journal-title":"J Neurosci"},{"issue":"10","key":"2732_CR25","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1101\/lm.678307","volume":"14","author":"V Nagy","year":"2007","unstructured":"Nagy V, Bozdagy O, Huntley WH (2007) The extracellular protease matrix metalloproteinase-9 is required by inhibitory avoidance learning and required for long term memory. Learn Mem 14(10):655\u2013664. https:\/\/doi.org\/10.1101\/lm.678307","journal-title":"Learn Mem"},{"issue":"1","key":"2732_CR26","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1152\/jn.00202.2007","volume":"98","author":"O Bozdagi","year":"2007","unstructured":"Bozdagi O, Nagy V, Kwei KT, Huntley GW (2007) In vivo roles for matrix metalloproteinase-9 in mature hippocampal synaptic physiology and plasticity. J Neurophysiol 98(1):334\u2013344. https:\/\/doi.org\/10.1152\/jn.00202.2007","journal-title":"J Neurophysiol"},{"issue":"4","key":"2732_CR27","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.biopsych.2006.09.012","volume":"62","author":"P Okulski","year":"2007","unstructured":"Okulski P, Jay TM, Jaworski J, Duniec K, Dzwonek K, Dzwonek J, Konopacki FA, Wilczynski GM, et al.(2007) TIMP-1 abolishes MMP-9-dependent long-lasting long-term potentiation in the prefrontal cortex. Biol Psychiatry 62(4):359\u2013362. https:\/\/doi.org\/10.1016\/j.biopsych.2006.09.012","journal-title":"Biol Psychiatry"},{"issue":"1\u20133","key":"2732_CR28","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.schres.2009.02.005","volume":"109","author":"JK Rybakowski","year":"2009","unstructured":"Rybakowski JK, Skibi\u0144ska M, Kapelski P, Kaczmarek L, Hauser J (2009) Functional polymorphism of the matrix metalloproteinase-9 (MMP-9) gene in schizophrenia. Schizophr Res 109(1\u20133):90\u201393. https:\/\/doi.org\/10.1016\/j.schres.2009.02.005","journal-title":"Schizophr Res"},{"key":"2732_CR29","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.neuropharm.2013.04.024","volume":"76","author":"P Bekinschtein","year":"2014","unstructured":"Bekinschtein P, Cammarota M, Medina JH (2014) BDNF and memory processing. Neuropharmacology 76:677\u2013683. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.04.024","journal-title":"Neuropharmacology"},{"issue":"17","key":"2732_CR30","doi-asserted-by":"publisher","first-page":"6690","DOI":"10.1523\/jneurosci.23-17-06690.2003","volume":"23","author":"AR Hariri","year":"2003","unstructured":"Hariri AR, Goldberg TE, Mattay VS, Kolachana BS, Callicott JH, Egan MF, Weinberger DR (2003) BDNF val66met polymorphism affects human memory\u2013related hippocampal activity and predicts memory performance. J Neurosci 23(17):6690\u20136694. https:\/\/doi.org\/10.1523\/jneurosci.23-17-06690.2003","journal-title":"J Neurosci"},{"key":"2732_CR31","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","volume":"76","author":"G Leal","year":"2014","unstructured":"Leal G, Comprido D, Duarte CB (2014) BDNF-induced local protein synthesis and synaptic plasticity. Neuropharmacology 76:639\u2013656. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.04.005","journal-title":"Neuropharmacology"},{"key":"2732_CR32","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1016\/j.neuropharm.2013.05.029","volume":"76","author":"M Zagrebelsky","year":"2014","unstructured":"Zagrebelsky M, Korte M (2014) Form follows function: BDNF and its involvement in sculpting the function and structure of synapses. Neuropharmacology 76:628\u2013638. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.05.029","journal-title":"Neuropharmacology"},{"key":"2732_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jad.2014.01.009","volume":"160","author":"K Sodersten","year":"2014","unstructured":"Sodersten K, Palsson E, Ishima T, Funa K, Landen M, Hashimoto K, Agren H (2014) Abnormality in serum levels of mature BDNF and its precursor proBDNF in mood stabilized patients with bipolar disorder: a study of two independent cohorts. J Affect Disord 160:1\u20139. https:\/\/doi.org\/10.1016\/j.jad.2014.01.009","journal-title":"J Affect Disord"},{"issue":"1","key":"2732_CR34","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pjnns.2016.10.001","volume":"51","author":"J Siuda","year":"2017","unstructured":"Siuda J, Patalong-Ogiewa M, \u017bmuda W, Targosz-Gajniak M, Niewiadomska E, Matuszek I, J\u0119drzejowska-Szypu\u0142ka H, Lewin-Kowalik J, et al. (2017) Cognitive impairment and BDNF serum levels. Neurol Neurochir Pol 51(1):24\u201332. https:\/\/doi.org\/10.1016\/j.pjnns.2016.10.001","journal-title":"Neurol Neurochir Pol"},{"issue":"36","key":"2732_CR35","doi-asserted-by":"publisher","first-page":"12963","DOI":"10.1523\/jneurosci.3118-11.2011","volume":"31","author":"H Mizoguchi","year":"2011","unstructured":"Mizoguchi H, Nakade J, Tachibana M, Ibi D, Someya E, Koike H, Kamei H, Nabeshima T, et al. (2011) Matrix metalloproteinase-9 contributes to kindled seizure development in pentylenetetrazole-treated mice by converting pro-BDNF to mature BDNF in the hippocampus. J Neurosci 31(36):12963\u201312971. https:\/\/doi.org\/10.1523\/jneurosci.3118-11.2011","journal-title":"J Neurosci"},{"issue":"4","key":"2732_CR36","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1111\/j.1440-1819.2010.02113.x","volume":"64","author":"K Hashimoto","year":"2010","unstructured":"Hashimoto K (2010) Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin Neurosci 64(4):341\u2013357. https:\/\/doi.org\/10.1111\/j.1440-1819.2010.02113.x","journal-title":"Psychiatry Clin Neurosci"},{"issue":"5","key":"2732_CR37","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1055\/s-2004-826232","volume":"84","author":"V Weichbold","year":"2005","unstructured":"Weichbold V, Tsiakpini L, Coninx F, D\u2019Haese P (2005) Development of a parent questionnaire for assessment of auditory behaviour of infants up to two years of age. Laryngorhinootologie 84(5):328\u2013334. https:\/\/doi.org\/10.1055\/s-2004-826232","journal-title":"Laryngorhinootologie"},{"issue":"7","key":"2732_CR38","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/j.ijporl.2009.04.010","volume":"73","author":"A Obrycka","year":"2009","unstructured":"Obrycka A, Padilla GJ, P., Pankowska A., Lorens A., Skar\u017cynski H. (2009) Production and evaluation of a Polish version of the LittlEars questionnaire for the assessment of auditory development in infants. Int J Pediatr Otorhinolaryngol 73(7):1035\u20131042. https:\/\/doi.org\/10.1016\/j.ijporl.2009.04.010","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2732_CR39","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.ijporl.2016.12.024","volume":"93","author":"A Obrycka","year":"2017","unstructured":"Obrycka A, Lorens A, Padilla JL, Piotrowska A, Skar\u017cy\u0144ski H (2017) Validation of the LittlEARS Auditory Questionnaire in cochlear implanted infants and toddlers. Int J Pediatr Otorhinolaryngol 93:107\u2013116. https:\/\/doi.org\/10.1016\/j.ijporl.2016.12.024","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"12","key":"2732_CR40","doi-asserted-by":"publisher","first-page":"1761","DOI":"10.1016\/j.ijporl.2009.09.036","volume":"73","author":"F Coninx","year":"2009","unstructured":"Coninx F, Weichbold V, Tsiakpini L, Autrique E, Bescond G, Tamas L, Compernol A, Georgescu M, Koroleva I, Le Maner-Idrissi G, Liang W, Madell J, Mii\u0107 B, Obrycka A, Pankowska A, Pascu A, Popescu R, Radulescu L, Reuhamaki T, Rouev P, Kabatova Z, Spitzer J, Thodi Ch, Varzic F, Vischer M, Wang L, Zavala JS, Brachmaier J (2009) Validation of the LittlEARS Auditory Questionnaire in children with normal hearing. Int J Pediatr Otorhinolaryngol 73(12):1761\u20131768. https:\/\/doi.org\/10.1016\/j.ijporl.2009.09.036","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"10","key":"2732_CR41","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1016\/j.ijporl.2011.07.030","volume":"75","author":"M Geal-Dor","year":"2011","unstructured":"Geal-Dor M, Jbarah R, Meilijson S, Adelman C, Levi H (2011) The Hebrew and the Arabic version of the LittlEARS Auditory Questionnaire for the assessment of auditory development: Results in normal hearing children and children with cochlear implants. Int J Pediatr Otorhinolaryngol 75(10):1327\u20131332. https:\/\/doi.org\/10.1016\/j.ijporl.2011.07.030","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"8","key":"2732_CR42","doi-asserted-by":"publisher","first-page":"1350","DOI":"10.1016\/j.ijporl.2013.05.033","volume":"77","author":"L Wanga","year":"2013","unstructured":"Wanga L, Sun X, Liang W, Chen J, Zheng W (2013) Validation of the Mandarin version of the LittlEARS Auditory Questionnaire. Int J Pediatr Otorhinolaryngol 77(8):1350\u20131354. https:\/\/doi.org\/10.1016\/j.ijporl.2013.05.033","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2732_CR43","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.ijporl.2016.01.021","volume":"83","author":"NA Garc\u00eda","year":"2016","unstructured":"Garc\u00eda NA, S., Padilla Garc\u00eda J. L., SainzQuevedo M., (2016) Production and evaluation of a Spanish version of the LittlEARS Auditory Questionnaire for the assessment of auditory development in children. Int J Pediatr Otorhinolaryngol 83:99\u2013103. https:\/\/doi.org\/10.1016\/j.ijporl.2016.01.021","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"Pt 1","key":"2732_CR44","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1111\/j.1469-1809.1995.tb01602.x","volume":"59","author":"JP St","year":"1995","unstructured":"St JP, L., Zhang X. C., Hart B. K., Lamlum H., Webster M. W., Steed D., L., Henney A., M., Ferrell R. E. (1995) Characterization of a dinucleotide repeat in the 92 kDa type IV collagenase gene (CLG4B), localization of CLG4B to chromosome 20 and the role of CLG4B in aortic aneurysmal disease. Ann Hum Genet 59(Pt 1):17\u201324. https:\/\/doi.org\/10.1111\/j.1469-1809.1995.tb01602.x","journal-title":"Ann Hum Genet"},{"issue":"1\u20132","key":"2732_CR45","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/s0014-5793(99)00863-7","volume":"455","author":"S Shimajiri","year":"1999","unstructured":"Shimajiri S, Arima N, Tanimoto A, Murata Y, Hamada T, Wang KY, Sasaguri Y (1999) Shortened microsatellite d(CA)21 sequence down-regulates promoter activity of matrix metalloproteinase 9 gene. FEBS Lett 455(1\u20132):70\u201374. https:\/\/doi.org\/10.1016\/s0014-5793(99)00863-7","journal-title":"FEBS Lett"},{"issue":"4","key":"2732_CR46","doi-asserted-by":"publisher","first-page":"901","DOI":"10.1016\/s0006-291x(02)02962-5","volume":"300","author":"T-S Huang","year":"2003","unstructured":"Huang T-S, Lee C-C, Chang A-C, Shankung L, Chao C-C, Jou Y-S, Chu Y-W, Wu C-W, et al. (2003) Shortening of microsatellite deoxy(CA) repeats involved in GL331-induced down-regulation of matrix metalloproteinase-9 gene expression. Biochem Biophys Res Commun 300(4):901\u2013907. https:\/\/doi.org\/10.1016\/s0006-291x(02)02962-5","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"2732_CR47","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.atherosclerosis.2010.12.010","volume":"215","author":"N Fiotti","year":"2011","unstructured":"Fiotti N, Moretti ME, Bussani R, Altamura N, Zamolo F, Gerloni R, Ukovich L, Ober E, et al. (2011) Features of vulnerable plaques and clinical outcome of UA\/NSTEMI: Relationship with matrix metalloproteinase functional polymorphisms. Atherosclerosis 215(1):153\u2013159. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2010.12.010","journal-title":"Atherosclerosis"},{"key":"2732_CR48","doi-asserted-by":"publisher","unstructured":"Hirakawa S, Lange E, Colicigno C, Freedman B, Rich S, Bowden D. Evaluation of genetic variation and association in the matrix metalloproteinase 9 (MMP9) gene in ESRD patients. Am J Kidney Dis 42:133\u201342. https:\/\/doi.org\/10.1016\/s0272-6386(03)00416-5","DOI":"10.1016\/s0272-6386(03)00416-5"},{"issue":"8","key":"2732_CR49","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.15252\/emmm.201707723","volume":"9","author":"K Lepeta","year":"2017","unstructured":"Lepeta K, Purzycka KJ, Pachulska-Wieczorek K, Mitjans M, Begemann M, Vafadari B, Bijata K, Adamiak RW, et al. (2017) A normal genetic variation modulates synaptic MMP-9 protein levels and the severity of schizophrenia symptoms. EMBO Mol Med 9(8):1100\u20131116. https:\/\/doi.org\/10.15252\/emmm.201707723","journal-title":"EMBO Mol Med"},{"key":"2732_CR50","doi-asserted-by":"publisher","first-page":"233121652110021","DOI":"10.1177\/23312165211002140","volume":"25","author":"M Matusiak","year":"2021","unstructured":"Matusiak M, Ozi\u0119b\u0142o D, Obrycka A, O\u0142dak M, Kaczmarek L, Skar\u017cy\u0144ski P, Skar\u017cy\u0144ski H (2021) Functional polymorphism of MMP9 and BDNF as a potential biomarker of auditory plasticity in prelingual deafness treatment with cochlear implantation: a retrospective cohort analysis. Trends Hear 25:23312165211002140. https:\/\/doi.org\/10.1177\/23312165211002140","journal-title":"Trends Hear"},{"key":"2732_CR51","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/j.schres.2017.01.016","volume":"188","author":"FT Ali","year":"2017","unstructured":"Ali FT, Abd El-Azeem EM, Hamed MA, Ali MAM, Abd Al-Kader NM, Hassan EA (2017) Redox dysregulation, immuno-inflammatory alterations and genetic variants of BDNF and MMP-9 in schizophrenia: pathophysiological and phenotypic implications. Schizophr Res. 188:98\u2013109. https:\/\/doi.org\/10.1016\/j.schres.2017.01.016","journal-title":"Schizophr Res."},{"issue":"3","key":"2732_CR52","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1080\/13651501.2019.1581895","volume":"23","author":"Q-R Xia","year":"2019","unstructured":"Xia Q-R, Zhang C, Liang J, Xu Y-Y (2019) The association of functional polymorphism of matrix metalloproteinase-9 gene (rs3918242) with schizophrenia: a meta-analysis. Int J Psychiatry Clin Pract 23(3):207\u2013214. https:\/\/doi.org\/10.1080\/13651501.2019.1581895","journal-title":"Int J Psychiatry Clin Pract"},{"key":"2732_CR53","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.brainres.2010.02.072","volume":"1327","author":"A Samochowiec","year":"2010","unstructured":"Samochowiec A, Grzywacz A, Kaczmarek L, Bienkowski P, Samochowiec J, Mierzejewski P, Preuss UW, Grochans E, et al. (2010) Functional polymorphism of matrix metalloproteinase-9 (MMP-9) gene in alcohol dependence: family case control study. Brain Res 1327:103\u2013106. https:\/\/doi.org\/10.1016\/j.brainres.2010.02.072","journal-title":"Brain Res"},{"issue":"2","key":"2732_CR54","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1002\/npr2.12098","volume":"40","author":"N Kudo","year":"2020","unstructured":"Kudo N, Yamamori H, Ishima T, Nemoto K, Yasuda Y, Fujimoto M, Azechi H, Niitsu T, et al. (2020) Plasma levels of matrix metalloproteinase-9 (MMP-9) are associated with cognitive performance in patients with schizophrenia. Neuropsychopharmacol Rep 40(2):150\u2013156. https:\/\/doi.org\/10.1002\/npr2.12098","journal-title":"Neuropsychopharmacol Rep"},{"issue":"Pt 19","key":"2732_CR55","doi-asserted-by":"publisher","first-page":"3369","DOI":"10.1242\/jcs.090852","volume":"124","author":"P Michaluk","year":"2011","unstructured":"Michaluk P, Wawrzyniak M, A lot P., Szczot M., Wyrembek P., Mercik K., Medvedev N., Wilczek E., et al. (2011) Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology. J Cell Sci 124(Pt 19):3369\u20133380. https:\/\/doi.org\/10.1242\/jcs.090852","journal-title":"J Cell Sci"},{"key":"2732_CR56","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.neuroscience.2011.02.043","volume":"181","author":"C Setz","year":"2011","unstructured":"Setz C, Brand Y, Radojevic V, Hanusek C, Mullen PJ, Levano S, Listyo A, Bodmer D (2011) Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition. Neuroscience 181:28\u201339. https:\/\/doi.org\/10.1016\/j.neuroscience.2011.02.043","journal-title":"Neuroscience"},{"issue":"7","key":"2732_CR57","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1007\/s10571-014-0077-2","volume":"34","author":"M Sung","year":"2014","unstructured":"Sung M, Wei E, Chavez E, Jain N, Levano S, Binkert L, Ramseier A, Setz C, et al. (2014) Inhibition of MMP-2 but not MMP-9 influences inner ear spiral ganglion neurons in vitro. Cell Mol Neurobiol 34(7):1011\u20131021. https:\/\/doi.org\/10.1007\/s10571-014-0077-2","journal-title":"Cell Mol Neurobiol"},{"issue":"2","key":"2732_CR58","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3892\/mmr.2017.6784","volume":"16","author":"J Wu","year":"2017","unstructured":"Wu J, Han W, Chen X, Guo W, Liu K, Wang R, Zhang J, Sai N (2017) Matrix metalloproteinase-2 and -9 contribute to functional integrity and noise-induced damage to the blood-labyrinth-barrier. Mol Med Rep 16(2):1731\u20131738. https:\/\/doi.org\/10.3892\/mmr.2017.6784","journal-title":"Mol Med Rep"},{"issue":"43","key":"2732_CR59","doi-asserted-by":"publisher","first-page":"14927","DOI":"10.1523\/JNEUROSCI.1588-12.2012","volume":"32","author":"BH Hu","year":"2012","unstructured":"Hu BH, Cai Q, Hu Z, Patel M, Bard J, Jamison J, Coling D (2012) Metalloproteinases and their associated genes contribute to the functional integrity and noise-induced damage in the cochlear sensory epithelium. J Neurosci 32(43):14927\u201314941. https:\/\/doi.org\/10.1523\/JNEUROSCI.1588-12.2012","journal-title":"J Neurosci"},{"issue":"36","key":"2732_CR60","doi-asserted-by":"publisher","first-page":"14591","DOI":"10.1523\/JNEUROSCI.5239-12.2013","volume":"33","author":"E Knapska","year":"2013","unstructured":"Knapska E, Lioudyno V, Kiryk A, Mikosz M, G\u00f3rkiewicz T, Michaluk P, Gawlak M, Chaturvedi M, et al. (2013) Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala. J Neurosci 33(36):14591\u201314600. https:\/\/doi.org\/10.1523\/JNEUROSCI.5239-12.2013","journal-title":"J Neurosci"},{"issue":"2","key":"2732_CR61","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1080\/08039488.2020.1808901","volume":"75","author":"N Keshri","year":"2021","unstructured":"Keshri N, Nandeesha H, Rajappa M, Menon V (2021) Matrix metalloproteinase-9 increases the risk of cognitive impairement in schizophrenia. Nord J Psychiatry 75(2):130\u2013134. https:\/\/doi.org\/10.1080\/08039488.2020.1808901","journal-title":"Nord J Psychiatry"},{"key":"2732_CR62","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.neulet.2013.09.059","volume":"556","author":"H Yamamori","year":"2013","unstructured":"Yamamori H, Hashimoro R, Ishima T, Kishi F, Yasuda Y, Ohi K, Fujimoto M, Umeda-Yanp S,\u00a0 et al. (2013) Plasma levels of matire brain-derived neurotrophic factor (BDNF) and matrix metalloproteinase-9 (MMP-9) in treatment-resistant schizophrenia treated with clozapine. Neurosci Lett 556:37\u201341. https:\/\/doi.org\/10.1016\/j.neulet.2013.09.059","journal-title":"Neurosci Lett"},{"key":"2732_CR63","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1136\/jmg.2008.061796","volume":"46","author":"TV Bilousova","year":"2009","unstructured":"Bilousova TV, Dansie L, Ngo M, Aye J, Charles JR, Ethell DW, Ethell IM (2009) Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet 46:94\u2013102. https:\/\/doi.org\/10.1136\/jmg.2008.061796","journal-title":"J Med Genet"},{"issue":"3","key":"2732_CR64","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1097\/DBP.0b013e318287cd17","volume":"34","author":"MJ Leigh","year":"2013","unstructured":"Leigh MJ, Nguyen DV, Mu Y, Winarni TI, Schneider A, Chechi T, Polussa J, Dpucet P,\u00a0 et al. (2013) A randomized double-blind, placebo-controlled trial of minocycline in children and adolescents with Fragile X Syndrome. J Dev Behav Pediatr 34(3):147\u2013155. https:\/\/doi.org\/10.1097\/DBP.0b013e318287cd17","journal-title":"J Dev Behav Pediatr"},{"issue":"10","key":"2732_CR65","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1177\/0269881113494105","volume":"27","author":"A Schenider","year":"2013","unstructured":"Schenider A, Leigh MJ, Adams P, Nanakul R, Chechi T, Olichney J, Hagerman R, Hessl D (2013) Electrocortical changes associated with minocycline treatment in fragile X syndrome. J Psychopharmacol 27(10):956\u2013963. https:\/\/doi.org\/10.1177\/0269881113494105","journal-title":"J Psychopharmacol"},{"issue":"8","key":"2732_CR66","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1017\/S1461145708009309","volume":"11","author":"AR Brunoni","year":"2008","unstructured":"Brunoni AR, Lopes M, Fregni F (2008) A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacol 11(8):1169\u20131180. https:\/\/doi.org\/10.1017\/S1461145708009309","journal-title":"Int J Neuropsychopharmacol"},{"issue":"8","key":"2732_CR67","doi-asserted-by":"publisher","first-page":"e42676","DOI":"10.1371\/journal.pone.0042676","volume":"7","author":"T Yoshida","year":"2012","unstructured":"Yoshida T, Ishikawa M, Niitsu T, Nakazato M, Watanabe H, Shiraishi T, Shiina A, Hashimoto T,\u00a0 et al. (2012) Decreased serum level of mature Brain-Derived Neurotrophic Factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS ONE 7(8):e42676. https:\/\/doi.org\/10.1371\/journal.pone.0042676","journal-title":"PLoS ONE"},{"key":"2732_CR68","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1744-859X-13-19","volume":"13","author":"R Yoshimura","year":"2014","unstructured":"Yoshimura R, Kishi T, Hori H, Atake K, Katsuki A, Nakano-Umene W, Ikenouchi-Sugita A, Uwata N, et al. (2014) Serum proBDNF\/BDNF and response to fluvoxamine in drug na\u00efve first-episode major depressive disorder patients. Ann Gen Psychiatry 13:19. https:\/\/doi.org\/10.1186\/1744-859X-13-19","journal-title":"Ann Gen Psychiatry"},{"key":"2732_CR69","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.conb.2019.11.003","volume":"60","author":"E Glennon","year":"2020","unstructured":"Glennon E, Svirsky MA, Froemke RC (2020) Auditory cortical plasticity in cochlear implant users. Curr Opin Neurobiol 60:108\u2013114. https:\/\/doi.org\/10.1016\/j.conb.2019.11.003","journal-title":"Curr Opin Neurobiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02732-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-02732-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02732-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,19]],"date-time":"2022-04-19T07:05:15Z","timestamp":1650351915000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-02732-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,21]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["2732"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-02732-7","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-579706\/v1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,21]]},"assertion":[{"value":"31 May 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 January 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was designed and conducted according to the Declaration of Helsinki. It was reviewed and approved by the Bioethics Committee of the Institute of Physiology and Pathology of Hearing (no. IFPS:KB\/13\/2015).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Parents or caregivers of all participants gave written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate and for Publication"}},{"value":"The authors declare that there is no conflict of interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}