{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T22:57:52Z","timestamp":1777417072579,"version":"3.51.4"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:00:00Z","timestamp":1648080000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1007\/s12035-022-02804-8","type":"journal-article","created":{"date-parts":[[2022,3,24]],"date-time":"2022-03-24T00:05:14Z","timestamp":1648080314000},"page":"3458-3466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor"],"prefix":"10.1007","volume":"59","author":[{"given":"Jos\u00e9 A. G.","family":"Ag\u00fandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f3nica","family":"D\u00edez-Fair\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"\u00c1lvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pau","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juli\u00e1n","family":"Benito-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tom\u00e1s","family":"L\u00f3pez-Alburquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix Javier","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,24]]},"reference":[{"key":"2804_CR1","doi-asserted-by":"publisher","unstructured":"Lou JS, Jankovic J (1991) Essential tremor: clinical correlates in 350 patients. Neurology. 41(2 ( Pt 1)): 234\u2013238. https:\/\/doi.org\/10.1212\/wnl.41.2_part_1.234.","DOI":"10.1212\/wnl.41.2_part_1.234"},{"issue":"4","key":"2804_CR2","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/s1353-8020(97)00031-x","volume":"3","author":"A Tall\u00f3n-Barranco","year":"1997","unstructured":"Tall\u00f3n-Barranco A, V\u00e1zquez A, Javier Jim\u00e9nez-Jim\u00e9nez F, Ort\u00ed-Pareja M, Gasalla T, Cabrera-Valdivia F, Benito-Le\u00f3n J, Molina JA (1997) Clinical features of essential tremor seen in neurology practice: a study of 357 patients. Parkinsonism Relat Disord 3(4):187\u2013190. https:\/\/doi.org\/10.1016\/s1353-8020(97)00031-x","journal-title":"Parkinsonism Relat Disord"},{"issue":"6","key":"2804_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1111\/ane.12148","volume":"128","author":"FJ Jim\u00e9nez-Jim\u00e9nez","year":"2013","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, Alonso-Navarro H, Garc\u00eda-Mart\u00edn E, Lorenzo-Betancor O, Pastor P, Ag\u00fandez JA (2013) Update on genetics of essential tremor. Acta Neurol Scand 128(6):359\u2013371. https:\/\/doi.org\/10.1111\/ane.12148","journal-title":"Acta Neurol Scand"},{"key":"2804_CR4","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2019.7","volume":"21","author":"H Deng","year":"2019","unstructured":"Deng H, Wu S, Jankovic J (2019) Essential tremor: genetic update. Expert Rev Mol Med 21:e8. https:\/\/doi.org\/10.1017\/erm.2019.7","journal-title":"Expert Rev Mol Med"},{"key":"2804_CR5","doi-asserted-by":"publisher","first-page":"4","DOI":"10.5334\/tohm.67","volume":"10","author":"V Siokas","year":"2020","unstructured":"Siokas V, Aloizou AM, Tsouris Z, Liampas I, Aslanidou P, Dastamani M, Brotis AG, Bogdanos DP, Hadjigeorgiou GM, Dardiotis E (2020) Genetic risk factors for essential tremor: a review. Tremor Other Hyperkinet Mov (N Y) 10:4. https:\/\/doi.org\/10.5334\/tohm.67","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"6","key":"2804_CR6","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3390\/ph14060516","volume":"14","author":"FJ Jim\u00e9nez-Jim\u00e9nez","year":"2021","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, Alonso-Navarro H, Garc\u00eda-Mart\u00edn E, \u00c1lvarez I, Pastor P, Ag\u00fandez JAG (2021) Genomic markers for essential tremor. Pharmaceuticals (Basel) 14(6):516. https:\/\/doi.org\/10.3390\/ph14060516","journal-title":"Pharmaceuticals (Basel)"},{"key":"2804_CR7","doi-asserted-by":"publisher","unstructured":"Liao C, Castonguay CE, Heilbron K, Vuokila V, Medeiros M, Houle G, Ak\u00e7imen F, Ross JP, Catoire H, Diez-Fairen M, Kang J, Mueller SH, Girard SL, Hopfner F, Lorenz D, Clark LN, Soto-Beasley AI, Klebe S, Hallett M, Wszolek ZK, Pendziwiat M, Lorenzo-Betancor O, Seppi K, Berg D, Vilari\u00f1o-G\u00fcell C, Postuma RB, Bernard G, Dupr\u00e9 N, Jankovic J, Testa CM, Ross OA, Arzberger T, Chouinard S, Louis ED, Mandich P, Vitale C, Barone P, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Ag\u00fandez JAG, Jim\u00e9nez-Jim\u00e9nez FJ, Pastor P, Rajput A, Deuschl G, Kuhlenba\u00fcmer G, Meijer IA, Dion PA, Rouleau GA; 23andMe Research Team (2022) Association of essential tremor with novel risk loci: a genome-wide association study and meta-analysis. JAMA Neurol. 2022 Jan 4. https:\/\/doi.org\/10.1001\/jamaneurol.2021.4781. Epub ahead of print.","DOI":"10.1001\/jamaneurol.2021.4781"},{"issue":"5","key":"2804_CR8","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/mds.1183","volume":"16","author":"ED Louis","year":"2001","unstructured":"Louis ED (2001) Etiology of essential tremor: should we be searching for environmental causes? Mov Disord 16(5):822\u2013829. https:\/\/doi.org\/10.1002\/mds.1183","journal-title":"Mov Disord"},{"issue":"2","key":"2804_CR9","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1159\/000103646","volume":"58","author":"FJ Jim\u00e9nez-Jim\u00e9nez","year":"2007","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, de Toledo-Heras M, Alonso-Navarro H, Ayuso-Peralta L, Ar\u00e9valo-Serrano J, Ballesteros-Barranco A, Puertas I, Jabbour-Wadih T, Barcenilla B (2007) Environmental risk factors for essential tremor. Eur Neurol 58(2):106\u2013113. https:\/\/doi.org\/10.1159\/000103646","journal-title":"Eur Neurol"},{"issue":"5","key":"2804_CR10","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1002\/acn3.758","volume":"6","author":"YL Ong","year":"2019","unstructured":"Ong YL, Deng X, Tan EK (2019) Etiologic links between environmental and lifestyle factors and Essential tremor. Ann Clin Transl Neurol 6(5):979\u2013989. https:\/\/doi.org\/10.1002\/acn3.758","journal-title":"Ann Clin Transl Neurol"},{"issue":"2","key":"2804_CR11","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1159\/000095702","volume":"56","author":"H Alonso-Navarro","year":"2006","unstructured":"Alonso-Navarro H, Mart\u00ednez C, Garc\u00eda-Mart\u00edn E, Benito-Le\u00f3n J, Garc\u00eda-Ferrer I, V\u00e1zquez-Torres P, Puertas I, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2006) CYP2C19 polymorphism and risk for essential tremor. Eur Neurol 56(2):119\u2013123. https:\/\/doi.org\/10.1159\/000095702","journal-title":"Eur Neurol"},{"issue":"2","key":"2804_CR12","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/BF02685892","volume":"9","author":"C Mart\u00ednez","year":"2007","unstructured":"Mart\u00ednez C, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Jim\u00e9nez-Jim\u00e9nez FJ, Benito-Le\u00f3n J, Garc\u00eda-Ferrer I, V\u00e1zquez-Torres P, Puertas I, Zurdo JM, L\u00f3pez-Alburquerque T, Ag\u00fandez JA (2007) Changes at the CYP2C locus and disruption of CYP2C8\/9 linkage disequilibrium in patients with essential tremor. Neuromolecular Med 9(2):195\u2013204. https:\/\/doi.org\/10.1007\/BF02685892","journal-title":"Neuromolecular Med"},{"issue":"3","key":"2804_CR13","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1007\/s12035-016-9815-4","volume":"54","author":"B Emamalizadeh","year":"2017","unstructured":"Emamalizadeh B, Jamshidi J, Movafagh A, Ohadi M, Khaniani MS, Kazeminasab S, Biglarian A, Taghavi S, Motallebi M, Fazeli A, Ahmadifard A, Shahidi GA, Petramfar P, Shahmohammadibeni N, Dadkhah T, Khademi E, Tafakhori A, Khaligh A, Safaralizadeh T, Kowsari A, Mirabzadeh A, Zarneh AES, Khorrami M, Shokraeian P, Banavandi MJS, Lima BS, Andarva M, Alehabib E, Atakhorrami M, Darvish H (2017) RIT2 Polymorphisms: is there a differential association? Mol Neurobiol 54(3):2234\u20132240. https:\/\/doi.org\/10.1007\/s12035-016-9815-4","journal-title":"Mol Neurobiol"},{"issue":"1","key":"2804_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/s12883-019-1331-5","volume":"19","author":"J Chen","year":"2019","unstructured":"Chen J, Huang P, He Y, Shen J, Du J, Cui S, Chen S, Ma J (2019) IL1B polymorphism is associated with essential tremor in Chinese population. BMC Neurol 19(1):99. https:\/\/doi.org\/10.1186\/s12883-019-1331-5","journal-title":"BMC Neurol"},{"issue":"2","key":"2804_CR15","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1007\/s12264-018-0287-6","volume":"35","author":"A Sazci","year":"2019","unstructured":"Sazci A, Uren N, Idrisoglu HA, Ergul E (2019) The rs2228570 Variant of the vitamin D receptor gene is associated with essential tremor. Neurosci Bull 35(2):362\u2013364. https:\/\/doi.org\/10.1007\/s12264-018-0287-6","journal-title":"Neurosci Bull"},{"issue":"5","key":"2804_CR16","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1111\/eci.12742","volume":"47","author":"JAG Ag\u00fandez","year":"2017","unstructured":"Ag\u00fandez JAG, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Ayuso P, Esguevillas G, Benito-Le\u00f3n J, Ortega-Cubero S, Pastor P, L\u00f3pez-Alburquerque T, Jim\u00e9nez-Jim\u00e9nez FJ (2017) Delta-amino-levulinic acid dehydratase gene and essential tremor. Eur J Clin Invest 47(5):348\u2013356. https:\/\/doi.org\/10.1111\/eci.12742","journal-title":"Eur J Clin Invest"},{"issue":"9","key":"2804_CR17","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1002\/mds.20565","volume":"20","author":"ED Louis","year":"2005","unstructured":"Louis ED, Applegate L, Graziano JH, Parides M, Slavkovich V, Bhat HK (2005) Interaction between blood lead concentration and delta-amino-levulinic acid dehydratase gene polymorphisms increases the odds of essential tremor. Mov Disord 20(9):1170\u20131177. https:\/\/doi.org\/10.1002\/mds.20565","journal-title":"Mov Disord"},{"key":"2804_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1038\/s41467-017-02662-2","volume":"9","author":"X Jiang","year":"2018","unstructured":"Jiang X, O\u2019Reilly PF, Aschard H, Hsu YH, Richards JB, Dupuis J, Ingelsson E, Karasik D, Pilz S, Berry D, Kestenbaum B, Zheng J, Luan J, Sofianopoulou E, Streeten EA, Albanes D, Lutsey PL, Yao L, Tang W, Econs MJ, Wallaschofski H, V\u00f6lzke H, Zhou A, Power C, McCarthy MI, Michos ED, Boerwinkle E, Weinstein SJ, Freedman ND, Huang WY, Van Schoor NM, van der Velde N, Groot LCPGM, Enneman A, Cupples LA, Booth SL, Vasan RS, Liu CT, Zhou Y, Ripatti S, Ohlsson C, Vandenput L, Lorentzon M, Eriksson JG, Shea MK, Houston DK, Kritchevsky SB, Liu Y, Lohman KK, Ferrucci L, Peacock M, Gieger C, Beekman M, Slagboom E, Deelen J, Heemst DV, Kleber ME, M\u00e4rz W, de Boer IH, Wood AC, Rotter JI, Rich SS, Robinson-Cohen C, den Heijer M, Jarvelin MR, Cavadino A, Joshi PK, Wilson JF, Hayward C, Lind L, Micha\u00eblsson K, Trompet S, Zillikens MC, Uitterlinden AG, Rivadeneira F, Broer L, Zgaga L, Campbell H, Theodoratou E, Farrington SM, Timofeeva M, Dunlop MG, Valdes AM, Tikkanen E, Lehtim\u00e4ki T, Lyytik\u00e4inen LP, K\u00e4h\u00f6nen M, Raitakari OT, Mikkil\u00e4 V, Ikram MA, Sattar N, Jukema JW, Wareham NJ, Langenberg C, Forouhi NG, Gundersen TE, Khaw KT, Butterworth AS, Danesh J, Spector T, Wang TJ, Hypp\u00f6nen E, Kraft P, Kiel DP (2018) Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. Nat Commun 9:260. https:\/\/doi.org\/10.1038\/s41467-017-02662-2","journal-title":"Nat Commun"},{"key":"2804_CR19","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1038\/s41467-020-15421-7","volume":"11","author":"JA Revez","year":"2020","unstructured":"Revez JA, Lin T, Qiao Z, Xue A, Holtz Y, Zhu Z, Zeng J, Wang H, Sidorenko J, Kemper KE, Vinkhuyzen AAE, Frater J, Eyles D, Burne THJ, Mitchell B, Martin NG, Zhu G, Visscher PM, Yang J, Wray NR, McGrath JJ (2020) Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration. Nat Commun 11:1647. https:\/\/doi.org\/10.1038\/s41467-020-15421-7","journal-title":"Nat Commun"},{"key":"2804_CR20","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.ajhg.2020.01.017","volume":"106","author":"D Manousaki","year":"2020","unstructured":"Manousaki D, Mitchell R, Dudding T, Haworth S, Harroud A, Forgetta V, Shah RL, Luan J, Langenberg C, Timpson NJ, Richards JB (2020) Genome-wide association study for vitamin d levels reveals 69 independent loci. Am J Hum Genet 106:327\u2013337. https:\/\/doi.org\/10.1016\/j.ajhg.2020.01.017","journal-title":"Am J Hum Genet"},{"issue":"1","key":"2804_CR21","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40520-019-01135-4","volume":"32","author":"J Geng","year":"2020","unstructured":"Geng J, Zhang J, Yao F, Liu X, Liu J, Huang Y (2020) A systematic review and meta-analysis of the associations of vitamin D receptor genetic variants with two types of most common neurodegenerative disorders. Aging Clin Exp Res 32(1):21\u201327. https:\/\/doi.org\/10.1007\/s40520-019-01135-4","journal-title":"Aging Clin Exp Res"},{"key":"2804_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134778","volume":"720","author":"J Gao","year":"2020","unstructured":"Gao J, Teng J, Liu Z, Cai M, Xie A (2020) Association between vitamin D receptor polymorphisms and susceptibility to Parkinson\u2019s disease: an updated meta-analysis. Neurosci Lett 720:134778. https:\/\/doi.org\/10.1016\/j.neulet.2020.134778","journal-title":"Neurosci Lett"},{"key":"2804_CR23","doi-asserted-by":"publisher","unstructured":"Liu N, Zhang T, Ma L, Wei W, Li Z, Jiang X, Sun J, Pei H, Li H (2021) Vitamin D receptor gene polymorphisms and risk of Alzheimer disease and mild cognitive impairment: a systematic review and meta-analysis. Adv Nutr. Jun 24: nmab074. https:\/\/doi.org\/10.1093\/advances\/nmab074. Epub ahead of print.","DOI":"10.1093\/advances\/nmab074"},{"key":"2804_CR24","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2020.108615","volume":"158","author":"A Mohammadi","year":"2020","unstructured":"Mohammadi A, Azarnezhad A, Khanbabaei H, Izadpanah E, Abdollahzadeh R, Barreto GE, Sahebkar A (2020) Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis: a systematic review and meta-analysis. Steroids 158:108615. https:\/\/doi.org\/10.1016\/j.steroids.2020.108615","journal-title":"Steroids"},{"key":"2804_CR25","doi-asserted-by":"crossref","unstructured":"Motaghi M, Haghjooy Javanmard S, Haghdoost F, Tajadini M, Saadatnia M, Rafiee L, Zandifar A (2013) Relationship between vitamin D receptor gene polymorphisms and migraine without aura in an Iranian population. Biomed Res Int. 2013: 351942.","DOI":"10.1155\/2013\/351942"},{"key":"2804_CR26","doi-asserted-by":"publisher","unstructured":"Prabhakar P, Majumdar V, Kulkarni GB, Christopher R. Genetic variants of vitamin D receptor and susceptibility to ischemic stroke (2015) Biochem Biophys Res Commun. 456(2):631\u2013636. https:\/\/doi.org\/10.1155\/2013\/351942.","DOI":"10.1155\/2013\/351942"},{"issue":"4","key":"2804_CR27","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1111\/ane.12463","volume":"133","author":"N T\u00f6r\u00f6k","year":"2016","unstructured":"T\u00f6r\u00f6k N, T\u00f6r\u00f6k R, Kliv\u00e9nyi P, Engelhardt J, V\u00e9csei L (2016) Investigation of vitamin D receptor polymorphisms in amyotrophic lateral sclerosis. Acta Neurol Scand 133(4):302\u2013308. https:\/\/doi.org\/10.1111\/ane.12463","journal-title":"Acta Neurol Scand"},{"issue":"11","key":"2804_CR28","doi-asserted-by":"publisher","first-page":"13913","DOI":"10.3390\/ijerph121113913","volume":"12","author":"P Jiang","year":"2015","unstructured":"Jiang P, Zhu WY, He X, Tang MM, Dang RL, Li HD, Xue Y, Zhang LH, Wu YQ, Cao LJ (2015) Association between vitamin D receptor gene polymorphisms with childhood temporal lobe epilepsy. Int J Environ Res Public Health 12(11):13913\u201313922. https:\/\/doi.org\/10.3390\/ijerph121113913","journal-title":"Int J Environ Res Public Health"},{"key":"2804_CR29","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.604052","volume":"12","author":"JL Han","year":"2021","unstructured":"Han JL, Yue YX, Gao X, Xie YC, Hao HJ, Li HY, Yu XL, Li J, Duan RS, Li HF (2021) Vitamin D receptor polymorphism and myasthenia gravis in Chinese Han population. Front Neurol 12:604052. https:\/\/doi.org\/10.3389\/fneur.2021.604052","journal-title":"Front Neurol"},{"issue":"1","key":"2804_CR30","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s12017-016-8415-9","volume":"19","author":"D Gezen-Ak","year":"2017","unstructured":"Gezen-Ak D, Alayl\u0131o\u011flu M, Gen\u00e7 G, G\u00fcnd\u00fcz A, Canda\u015f E, Bilgi\u00e7 B, Atasoy \u0130L, Apayd\u0131n H, K\u0131z\u0131ltan G, G\u00fcrvit H, Hana\u011fas\u0131 H, Ertan S, Y\u0131lmazer S, Dursun E (2017) GC and VDR SNPs and vitamin D levels in Parkinson\u2019s disease: the relevance to clinical features. Neuromolecular Med 19(1):24\u201340. https:\/\/doi.org\/10.1007\/s12017-016-8415-9","journal-title":"Neuromolecular Med"},{"issue":"47","key":"2804_CR31","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002125","volume":"94","author":"FJ Jim\u00e9nez-Jim\u00e9nez","year":"2015","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Mart\u00ednez C, Zurdo M, Turp\u00edn-Fenoll L, Mill\u00e1n-Pascual J, Adeva-Bartolom\u00e9 T, Cubo E, Navacerrada F, Rojo-Sebasti\u00e1n A, Rubio L, Ortega-Cubero S, Pastor P, Calleja M, Plaza-Nieto JF, Pilo-De-La-Fuente B, Arroyo-Solera M, Garc\u00eda-Albea E, Ag\u00fandez JAG (2015) Association between vitamin D receptor rs731236 (Taq1) polymorphism and risk for restless legs syndrome in the Spanish caucasian population. Medicine (Baltimore) 94(47):e2125. https:\/\/doi.org\/10.1097\/MD.0000000000002125","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"2804_CR32","doi-asserted-by":"publisher","first-page":"1461","DOI":"10.1007\/s00415-020-10312-9","volume":"268","author":"FJ Jim\u00e9nez-Jim\u00e9nez","year":"2021","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, Amo G, Alonso-Navarro H, Calleja M, D\u00edez-Fair\u00e9n M, \u00c1lvarez I, Pastor P, Plaza-Nieto JF, Navarro-Mu\u00f1oz S, Turp\u00edn-Fenoll L, Mill\u00e1n-Pascual J, Recio-Bermejo M, Garc\u00eda-Ruiz R, Garc\u00eda-Albea E, Ag\u00fandez JAG, Garc\u00eda-Mart\u00edn E (2021) Serum vitamin D, vitamin D receptor and binding protein genes polymorphisms in restless legs syndrome. J Neurol 268(4):1461\u20131472. https:\/\/doi.org\/10.1007\/s00415-020-10312-9","journal-title":"J Neurol"},{"key":"2804_CR33","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.jneuroim.2017.02.009","volume":"305","author":"C Agliardi","year":"2017","unstructured":"Agliardi C, Guerini FR, Zanzottera M, Bolognesi E, Costa AS, Clerici M (2017) Vitamin D-binding protein gene polymorphisms are not associated with MS risk in an Italian cohort. J Neuroimmunol 305:92\u201395. https:\/\/doi.org\/10.1016\/j.jneuroim.2017.02.009","journal-title":"J Neuroimmunol"},{"issue":"Suppl 3","key":"2804_CR34","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/mds.870131303","volume":"13","author":"G Deuschl","year":"1998","unstructured":"Deuschl G, Bain P, Brin M (1998) Consensus statement of the movement disorder society on tremor. Ad Hoc Sci Committee Mov Disord 13(Suppl 3):2\u201323. https:\/\/doi.org\/10.1002\/mds.870131303","journal-title":"Ad Hoc Sci Committee Mov Disord"},{"issue":"24","key":"2804_CR35","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000000968","volume":"94","author":"P Ayuso","year":"2015","unstructured":"Ayuso P, Ag\u00fandez JAG, Alonso-Navarro H, Mart\u00ednez C, Benito-Le\u00f3n J, Ortega-Cubero S, Lorenzo-Betancor O, Pastor P, L\u00f3pez-Alburquerque T, Garc\u00eda-Mart\u00edn E, Jim\u00e9nez-Jim\u00e9nez FJ (2015) Heme oxygenase 1 and 2 common genetic variants and risk for essential tremor. Medicine (Baltimore) 94(24):e968. https:\/\/doi.org\/10.1097\/MD.0000000000000968","journal-title":"Medicine (Baltimore)"},{"key":"2804_CR36","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1097\/wnf.0b013e3180413d94","volume":"30","author":"C Mart\u00ednez","year":"2007","unstructured":"Mart\u00ednez C, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Benito-Le\u00f3n J, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2007) Alcohol dehydrogenase 2 genotype and allelic variants are not associated with the risk for essential tremor. Clin Neuropharmacol 30:196\u2013200. https:\/\/doi.org\/10.1097\/wnf.0b013e3180413d94","journal-title":"Clin Neuropharmacol"},{"issue":"3","key":"2804_CR37","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1111\/j.1468-1331.2007.02040.x","volume":"15","author":"C Mart\u00ednez","year":"2008","unstructured":"Mart\u00ednez C, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Benito-Le\u00f3n J, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2008) Glutathione-S-transferase P1 polymorphism and risk for essential tremor. Eur J Neurol 15(3):234\u2013238. https:\/\/doi.org\/10.1111\/j.1468-1331.2007.02040.x","journal-title":"Eur J Neurol"},{"issue":"4","key":"2804_CR38","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1007\/s12017-008-8040-3","volume":"10","author":"MC Ledesma","year":"2008","unstructured":"Ledesma MC, Garc\u00eda-Mart\u00edn E, Alonso-Navarro H, Mart\u00ednez C, Jim\u00e9nez-Jim\u00e9nez FJ, Benito-Le\u00f3n J, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA (2008) The nonsynonymous Thr105Ile polymorphism of the histamine N-methyltransferase is associated to the risk of developing essential tremor. Neuromol Med 10(4):356\u2013361. https:\/\/doi.org\/10.1007\/s12017-008-8040-3","journal-title":"Neuromol Med"},{"issue":"6","key":"2804_CR39","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/j.1468-1331.2009.02914.x","volume":"17","author":"E Garc\u00eda-Mart\u00edn","year":"2010","unstructured":"Garc\u00eda-Mart\u00edn E, Mart\u00ednez C, Alonso-Navarro H, Benito-Le\u00f3n J, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2010) Paraoxonase 1 (PON1) polymorphisms and risk for essential tremor. Eur J Neurol 17(6):879\u2013881. https:\/\/doi.org\/10.1111\/j.1468-1331.2009.02914.x","journal-title":"Eur J Neurol"},{"issue":"2","key":"2804_CR40","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1007\/s00415-010-5708-z","volume":"258","author":"E Garc\u00eda-Mart\u00edn","year":"2011","unstructured":"Garc\u00eda-Mart\u00edn E, Mart\u00ednez C, Alonso-Navarro H, Benito-Le\u00f3n J, Lorenzo-Betancor O, Pastor P, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2011) Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor. J Neurol 258(2):203\u2013211. https:\/\/doi.org\/10.1007\/s00415-010-5708-z","journal-title":"J Neurol"},{"issue":"8","key":"2804_CR41","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/j.1468-1331.2010.03251.x","volume":"18","author":"O Lorenzo-Betancor","year":"2011","unstructured":"Lorenzo-Betancor O, Garc\u00eda-Mart\u00edn E, Cervantes S, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ, Alonso-Navarro H, Luengo A, Coria F, Lorenzo E, Irigoyen J, Pastor P (2011) Lack of association of LINGO1 rs9652490 and rs11856808 SNPs with familial essential tremor. Eur J Neurol 18(8):1085\u20131089. https:\/\/doi.org\/10.1111\/j.1468-1331.2010.03251.x","journal-title":"Eur J Neurol"},{"issue":"7","key":"2804_CR42","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1097\/FPC.0b013e328345bec0","volume":"21","author":"E Garc\u00eda-Mart\u00edn","year":"2011","unstructured":"Garc\u00eda-Mart\u00edn E, Mart\u00ednez C, Alonso-Navarro H, Benito-Le\u00f3n J, Lorenzo-Betancor O, Pastor P, Puertas I, Rubio L, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2011) Gamma-aminobutyric acid GABRA4, GABRE, and GABRQ receptor polymorphisms and risk for essential tremor. Pharmacog Geno 21(7):436\u2013439. https:\/\/doi.org\/10.1097\/FPC.0b013e328345bec0","journal-title":"Pharmacog Geno"},{"key":"2804_CR43","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041581","volume":"7","author":"E Garc\u00eda-Mart\u00edn","year":"2012","unstructured":"Garc\u00eda-Mart\u00edn E, Mart\u00ednez C, Alonso-Navarro H, Benito-Le\u00f3n J, Lorenzo-Betancor O, Pastor P, L\u00f3pez-Alburquerque T, Samaranch L, Lorenzo E, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2012) H1-MAPT and the risk for familial essential tremor. PLoS ONE 7:e41581. https:\/\/doi.org\/10.1371\/journal.pone.0041581","journal-title":"PLoS ONE"},{"issue":"11","key":"2804_CR44","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1097\/FPC.0b013e328364db9d","volume":"23","author":"E Garc\u00eda-Mart\u00edn","year":"2013","unstructured":"Garc\u00eda-Mart\u00edn E, Mart\u00ednez C, Alonso-Navarro H, Benito-Le\u00f3n J, Lorenzo-Betancor O, Pastor P, Ortega-Cubero S, L\u00f3pez-Alburquerque T, Ag\u00fandez JA, Jim\u00e9nez-Jim\u00e9nez FJ (2013) No association of the SLC1A2 rs3794087 allele with risk for essential tremor in the Spanish population. Pharmacog Geno 23(11):587\u2013590. https:\/\/doi.org\/10.1097\/FPC.0b013e328364db9d","journal-title":"Pharmacog Geno"},{"issue":"6947","key":"2804_CR45","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1136\/bmj.309.6947.102","volume":"309","author":"DG Altman","year":"1994","unstructured":"Altman DG, Bland JM (1994) Diagnostic tests 2: predictive values. BMJ 309(6947):102. https:\/\/doi.org\/10.1136\/bmj.309.6947.102","journal-title":"BMJ"},{"key":"2804_CR46","doi-asserted-by":"crossref","unstructured":"Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Statis. Soc Ser B. 1995; 57 (1): 289\u2013300. not available.","DOI":"10.1111\/j.2517-6161.1995.tb02031.x"},{"issue":"1\u20132","key":"2804_CR47","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.mce.2011.05.014","volume":"347","author":"JP Kesby","year":"2011","unstructured":"Kesby JP, Eyles DW, Burne TH, McGrath JJ (2011) The effects of vitamin D on brain development and adult brain function. Mol Cell Endocrinol 347(1\u20132):121\u2013127. https:\/\/doi.org\/10.1016\/j.mce.2011.05.014","journal-title":"Mol Cell Endocrinol"},{"issue":"36","key":"2804_CR48","doi-asserted-by":"publisher","first-page":"21760","DOI":"10.1016\/S0021-9258(20)88249-0","volume":"264","author":"JF McLeod","year":"1989","unstructured":"McLeod JF, Cooke NE (1989) The vitamin D-binding protein, alpha-fetoprotein, albumin multigene family: detection of transcripts in multiple tissues. J Biol Chem 264(36):21760\u201321769","journal-title":"J Biol Chem"},{"issue":"1","key":"2804_CR49","doi-asserted-by":"publisher","first-page":"29","DOI":"10.3233\/JPD-150615","volume":"6","author":"LM Rimmelzwaan","year":"2016","unstructured":"Rimmelzwaan LM, van Schoor NM, Lips P, Berendse HW, Eekhoff EM (2016) Systematic review of the relationship between vitamin D and Parkinson\u2019s disease. J Parkinsons Dis 6(1):29\u201337. https:\/\/doi.org\/10.3233\/JPD-150615","journal-title":"J Parkinsons Dis"},{"key":"2804_CR50","doi-asserted-by":"publisher","first-page":"454","DOI":"10.3389\/fneur.2020.00454","volume":"11","author":"ME Fullard","year":"2020","unstructured":"Fullard ME, Duda JE (2020) A review of the relationship between vitamin D and Parkinson disease symptoms. Front Neurol 11:454. https:\/\/doi.org\/10.3389\/fneur.2020.00454","journal-title":"Front Neurol"},{"key":"2804_CR51","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez-Jim\u00e9nez FJ, Alonso-Navarro H, Garc\u00eda-Mart\u00edn E, Ag\u00fandez JA (2012) The relationship between Parkinson's disease and essential tremor: review of clinical, epidemiologic, genetic, neuroimaging and neuropathological data, and data on the presence of cardinal signs of parkinsonism in essential tremor. Tremor Other Hyperkinet Mov (N Y). 2:tre-02\u201375\u2013409\u20133.","DOI":"10.5334\/tohm.118"},{"key":"2804_CR52","doi-asserted-by":"publisher","unstructured":"Louis ED (2016) Non-motor symptoms in essential tremor: a review of the current data and state of the field. Parkinsonism Relat Disord. 22 Suppl 1(0 1):S115-S1188. https:\/\/doi.org\/10.1016\/j.parkreldis.2015.08.034.","DOI":"10.1016\/j.parkreldis.2015.08.034"},{"issue":"33","key":"2804_CR53","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000004607","volume":"95","author":"J Benito-Le\u00f3n","year":"2016","unstructured":"Benito-Le\u00f3n J, Contador I, Louis ED, Cosentino S, Bermejo-Pareja F (2016) Education and risk of incident dementia during the premotor and motor phases of essential tremor (NEDICES). Medicine (Baltimore) 95(33):e4607. https:\/\/doi.org\/10.1097\/MD.0000000000004607","journal-title":"Medicine (Baltimore)"},{"issue":"20","key":"2804_CR54","doi-asserted-by":"publisher","first-page":"948","DOI":"10.1212\/WNL.0000000000007500","volume":"92","author":"H Alonso-Navarro","year":"2019","unstructured":"Alonso-Navarro H, Garc\u00eda-Mart\u00edn E, Ag\u00fandez JAG, Jim\u00e9nez-Jim\u00e9nez FJ (2019) Association between restless legs syndrome and other movement disorders. Neurology 92(20):948\u2013964. https:\/\/doi.org\/10.1212\/WNL.0000000000007500","journal-title":"Neurology"},{"issue":"4","key":"2804_CR55","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/mds.10376","volume":"18","author":"J Benito-Le\u00f3n","year":"2003","unstructured":"Benito-Le\u00f3n J, Bermejo-Pareja F, Morales JM, Vega S, Molina JA (2003) Prevalence of essential tremor in three elderly populations of central Spain. Mov Disord 18(4):389\u2013394. https:\/\/doi.org\/10.1002\/mds.10376","journal-title":"Mov Disord"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02804-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-02804-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02804-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T05:14:44Z","timestamp":1653714884000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-02804-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,24]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["2804"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-02804-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,24]]},"assertion":[{"value":"3 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 March 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The study was approved by the corresponding Ethics Committees of the Hospitals involved. Specifically, the Ethics Committees of University Hospital \u201cPr\u00edncipe de Asturias,\u201d Universidad de Alcal\u00e1, Alcal\u00e1 de Henares (Madrid, Spain) and University Hospital \u201cInfanta Cristina\u201d (Badajoz, Spain). Written informed consent was obtained from all the participants before study enrollment.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}