{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T04:34:47Z","timestamp":1792816487626,"version":"4.5.0"},"reference-count":147,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2022,5,20]],"date-time":"2022-05-20T00:00:00Z","timestamp":1653004800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s12035-022-02860-0","type":"journal-article","created":{"date-parts":[[2022,5,19]],"date-time":"2022-05-19T21:02:45Z","timestamp":1652994165000},"page":"4669-4702","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Differential Regulation of Mouse Hippocampal Gene Expression Sex Differences by Chromosomal Content and Gonadal Sex"],"prefix":"10.1007","volume":"59","author":[{"given":"Sarah R.","family":"Oca\u00f1as","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor A.","family":"Ansere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyla B.","family":"Tooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niran","family":"Hadad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana J.","family":"Chucair-Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Wronowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica M.","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven N.","family":"Austad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Stout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-999X","authenticated-orcid":false,"given":"Willard M.","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,5,20]]},"reference":[{"issue":"8","key":"2860_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","volume":"14","author":"MT Ferretti","year":"2018","unstructured":"Ferretti MT et al (2018) Sex differences in Alzheimer disease - the gateway to precision medicine. Nat Rev Neurol 14(8):457\u2013469","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"2860_CR2","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1093\/brain\/awz206","volume":"142","author":"L Dumitrescu","year":"2019","unstructured":"Dumitrescu L et al (2019) Sex differences in the genetic predictors of Alzheimer\u2019s pathology. Brain 142(9):2581\u20132589","journal-title":"Brain"},{"issue":"1","key":"2860_CR3","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/s13293-020-00326-3","volume":"11","author":"RR Voskuhl","year":"2020","unstructured":"Voskuhl RR et al (2020) Sex differences in brain atrophy in multiple sclerosis. Biol Sex Differ 11(1):49","journal-title":"Biol Sex Differ"},{"issue":"6","key":"2860_CR4","first-page":"797","volume":"6","author":"C Jobin","year":"2010","unstructured":"Jobin C et al (2010) Gender Issues in Multiple Sclerosis: An Update. Womens Health 6(6):797\u2013820","journal-title":"Womens Health"},{"issue":"2","key":"2860_CR5","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1097\/WCO.0b013e32835ee548","volume":"26","author":"DM Werling","year":"2013","unstructured":"Werling DM, Geschwind DH (2013) Sex differences in autism spectrum disorders. Curr Opin Neurol 26(2):146\u2013153","journal-title":"Curr Opin Neurol"},{"issue":"6","key":"2860_CR6","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1111\/jcpp.12337","volume":"56","author":"AB Arnett","year":"2015","unstructured":"Arnett AB et al (2015) Sex differences in ADHD symptom severity. J Child Psychol Psychiatry 56(6):632\u2013639","journal-title":"J Child Psychol Psychiatry"},{"key":"2860_CR7","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.pneurobio.2019.01.006","volume":"176","author":"RS Eid","year":"2019","unstructured":"Eid RS, Gobinath AR, Galea LAM (2019) Sex differences in depression: Insights from clinical and preclinical studies. Prog Neurobiol 176:86\u2013102","journal-title":"Prog Neurobiol"},{"issue":"2","key":"2860_CR8","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1080\/08952841.2018.1419476","volume":"31","author":"SL Burke","year":"2019","unstructured":"Burke SL et al (2019) Sex differences in the development of mild cognitive impairment and probable Alzheimer\u2019s disease as predicted by hippocampal volume or white matter hyperintensities. J Women Aging 31(2):140\u2013164","journal-title":"J Women Aging"},{"issue":"2","key":"2860_CR9","doi-asserted-by":"publisher","first-page":"197","DOI":"10.31887\/DCNS.2002.4.2\/rgur","volume":"4","author":"RE Gur","year":"2002","unstructured":"Gur RE, Gur RC (2002) Gender differences in aging: cognition, emotions, and neuroimaging studies. Dialogues Clin Neurosci 4(2):197\u2013210","journal-title":"Dialogues Clin Neurosci"},{"issue":"4","key":"2860_CR10","doi-asserted-by":"publisher","first-page":"239","DOI":"10.4103\/0972-2327.104323","volume":"15","author":"KS Anand","year":"2012","unstructured":"Anand KS, Dhikav V (2012) Hippocampus in health and disease: An overview. Ann Indian Acad Neurol 15(4):239\u2013246","journal-title":"Ann Indian Acad Neurol"},{"issue":"1","key":"2860_CR11","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1038\/s41386-018-0208-4","volume":"44","author":"S Yagi","year":"2019","unstructured":"Yagi S, Galea LAM (2019) Sex differences in hippocampal cognition and neurogenesis. Neuropsychopharmacology 44(1):200\u2013213","journal-title":"Neuropsychopharmacology"},{"key":"2860_CR12","unstructured":"Purves D, A.G., Fitzpatrick D, et al., editors., Neuroscience. 2nd edition ed. 2001, Sunderland (MA): Sinauer Associates."},{"issue":"4","key":"2860_CR13","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1442-200X.1996.tb03512.x","volume":"38","author":"PY Fechner","year":"1996","unstructured":"Fechner PY (1996) The role of SRY in mammalian sex determination. Acta Paediatr Jpn 38(4):380\u2013389","journal-title":"Acta Paediatr Jpn"},{"issue":"10250","key":"2860_CR14","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0140-6736(20)31561-0","volume":"396","author":"F Mauvais-Jarvis","year":"2020","unstructured":"Mauvais-Jarvis F et al (2020) Sex and gender: modifiers of health, disease, and medicine. Lancet 396(10250):565\u2013582","journal-title":"Lancet"},{"issue":"1","key":"2860_CR15","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s10577-012-9274-3","volume":"20","author":"S Eggers","year":"2012","unstructured":"Eggers S, Sinclair A (2012) Mammalian sex determination-insights from humans and mice. Chromosome Res 20(1):215\u2013238","journal-title":"Chromosome Res"},{"key":"2860_CR16","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1210\/endo-65-3-369","volume":"65","author":"CH Phoenix","year":"1959","unstructured":"Phoenix CH et al (1959) Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female guinea pig. Endocrinology 65:369\u2013382","journal-title":"Endocrinology"},{"key":"2860_CR17","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.expneurol.2014.01.021","volume":"259","author":"AP Arnold","year":"2014","unstructured":"Arnold AP (2014) Conceptual frameworks and mouse models for studying sex differences in physiology and disease: why compensation changes the game. Exp Neurol 259:2\u20139","journal-title":"Exp Neurol"},{"key":"2860_CR18","doi-asserted-by":"publisher","first-page":"430","DOI":"10.3389\/fnagi.2017.00430","volume":"9","author":"S Z\u00e1rate","year":"2017","unstructured":"Z\u00e1rate S, Stevnsner T, Gredilla R (2017) Role of Estrogen and Other Sex Hormones in Brain Aging. Neuroprotection and DNA Repair. Front Aging Neurosci 9:430\u2013430","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"2860_CR19","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1007\/s13311-019-00766-9","volume":"16","author":"JK Russell","year":"2019","unstructured":"Russell JK, Jones CK, Newhouse PA (2019) The Role of Estrogen in Brain and Cognitive Aging. Neurotherapeutics 16(3):649\u2013665","journal-title":"Neurotherapeutics"},{"issue":"4","key":"2860_CR20","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.yhbeh.2009.02.004","volume":"55","author":"MM Martel","year":"2009","unstructured":"Martel MM et al (2009) Potential hormonal mechanisms of attention-deficit\/hyperactivity disorder and major depressive disorder: a new perspective. Horm Behav 55(4):465\u2013479","journal-title":"Horm Behav"},{"key":"2860_CR21","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.2147\/NDT.S136717","volume":"13","author":"L-J Wang","year":"2017","unstructured":"Wang L-J et al (2017) Potential role of pre- and postnatal testosterone levels in attention-deficit\/hyperactivity disorder: is there a sex difference? Neuropsychiatr Dis Treat 13:1331\u20131339","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"2860_CR22","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1007\/s12035-015-9315-y","volume":"53","author":"W Lv","year":"2016","unstructured":"Lv W et al (2016) Low Testosterone Level and Risk of Alzheimer\u2019s Disease in the Elderly Men: a Systematic Review and Meta-Analysis. Mol Neurobiol 53(4):2679\u20132684","journal-title":"Mol Neurobiol"},{"key":"2860_CR23","doi-asserted-by":"crossref","unstructured":"PM Maki LM Girard JE Manson 2019 Menopausal hormone therapy and cognition Bmj 364 l877","DOI":"10.1136\/bmj.l877"},{"key":"2860_CR24","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l665","volume":"364","author":"H Savolainen-Peltonen","year":"2019","unstructured":"Savolainen-Peltonen H et al (2019) Use of postmenopausal hormone therapy and risk of Alzheimer\u2019s disease in Finland: nationwide case-control study. BMJ 364:l665","journal-title":"BMJ"},{"issue":"11","key":"2860_CR25","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1212\/WNL.0000000000003696","volume":"88","author":"B Imtiaz","year":"2017","unstructured":"Imtiaz B et al (2017) Postmenopausal hormone therapy and Alzheimer disease: A prospective cohort study. Neurology 88(11):1062\u20131068","journal-title":"Neurology"},{"issue":"5","key":"2860_CR26","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1093\/aje\/kwu146","volume":"180","author":"A Fournier","year":"2014","unstructured":"Fournier A et al (2014) Risks of Endometrial Cancer Associated With Different Hormone Replacement Therapies in the E3N Cohort, 1992\u20132008. Am J Epidemiol 180(5):508\u2013517","journal-title":"Am J Epidemiol"},{"issue":"3","key":"2860_CR27","first-page":"191","volume":"4","author":"V Beral","year":"1999","unstructured":"Beral V et al (1999) Use of HRT and the subsequent risk of cancer. J Epidemiol Biostat 4(3):191\u2013210 (Discussion 210-5)","journal-title":"J Epidemiol Biostat"},{"key":"2860_CR28","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1196\/annals.1286.018","volume":"1007","author":"AP Arnold","year":"2003","unstructured":"Arnold AP, Rissman EF, De Vries GJ (2003) Two perspectives on the origin of sex differences in the brain. Ann N Y Acad Sci 1007:176\u2013188","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"2860_CR29","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1006\/hbeh.1996.0053","volume":"30","author":"AP Arnold","year":"1996","unstructured":"Arnold AP (1996) Genetically Triggered Sexual Differentiation of Brain and Behavior. Horm Behav 30(4):495\u2013505","journal-title":"Horm Behav"},{"issue":"5","key":"2860_CR30","doi-asserted-by":"publisher","first-page":"1099","DOI":"10.1084\/jem.20070850","volume":"205","author":"DL Smith-Bouvier","year":"2008","unstructured":"Smith-Bouvier DL et al (2008) A role for sex chromosome complement in the female bias in autoimmune disease. J Exp Med 205(5):1099\u20131108","journal-title":"J Exp Med"},{"issue":"1","key":"2860_CR31","doi-asserted-by":"publisher","first-page":"e12871","DOI":"10.1111\/acel.12871","volume":"18","author":"EJ Davis","year":"2019","unstructured":"Davis EJ, Lobach I, Dubal DB (2019) Female XX sex chromosomes increase survival and extend lifespan in aging mice. Aging Cell 18(1):e12871\u2013e12871","journal-title":"Aging Cell"},{"key":"2860_CR32","doi-asserted-by":"crossref","unstructured":"Davis EJ, et al., 2020 A second X chromosome contributes to resilience in a mouse model of Alzheimer's disease. Sci Transl Med, 12(558).","DOI":"10.1126\/scitranslmed.aaz5677"},{"issue":"11","key":"2860_CR33","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1038\/ejhg.2017.128","volume":"25","author":"AA Maan","year":"2017","unstructured":"Maan AA et al (2017) The Y chromosome: a blueprint for men\u2019s health? Eur J Hum Genet 25(11):1181\u20131188","journal-title":"Eur J Hum Genet"},{"issue":"6","key":"2860_CR34","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1038\/ng.2966","volume":"46","author":"LA Forsberg","year":"2014","unstructured":"Forsberg LA et al (2014) Mosaic loss of chromosome Y in peripheral blood is associated with shorter survival and higher risk of cancer. Nat Genet 46(6):624\u2013628","journal-title":"Nat Genet"},{"issue":"6","key":"2860_CR35","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1016\/j.ajhg.2016.05.014","volume":"98","author":"JP Dumanski","year":"2016","unstructured":"Dumanski JP et al (2016) Mosaic Loss of Chromosome Y in Blood Is Associated with Alzheimer Disease. Am J Human Genetics 98(6):1208\u20131219","journal-title":"Am J Human Genetics"},{"key":"2860_CR36","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fcell.2019.00219","volume":"7","author":"H Fang","year":"2019","unstructured":"Fang H, Disteche CM, Berletch JB (2019) X Inactivation and Escape: Epigenetic and Structural Features. Front Cell Dev Biol 7:219","journal-title":"Front Cell Dev Biol"},{"issue":"5","key":"2860_CR37","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.ajhg.2013.03.017","volume":"92","author":"AL Wise","year":"2013","unstructured":"Wise AL, Gyi L, Manolio TA (2013) eXclusion: toward integrating the X chromosome in genome-wide association analyses. Am J Hum Genet 92(5):643\u2013647","journal-title":"Am J Hum Genet"},{"issue":"12","key":"2860_CR38","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.biopsych.2020.12.024","volume":"89","author":"J Martin","year":"2021","unstructured":"Martin J et al (2021) Examining Sex-Differentiated Genetic Effects Across Neuropsychiatric and Behavioral Traits. Biol Psychiat 89(12):1127\u20131137","journal-title":"Biol Psychiat"},{"issue":"4","key":"2860_CR39","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1007\/s11689-011-9089-0","volume":"3","author":"RC Knickmeyer","year":"2011","unstructured":"Knickmeyer RC, Davenport M (2011) Turner syndrome and sexual differentiation of the brain: implications for understanding male-biased neurodevelopmental disorders. J Neurodev Disord 3(4):293\u2013306","journal-title":"J Neurodev Disord"},{"issue":"3","key":"2860_CR40","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/ejhg.2009.109","volume":"18","author":"M Otter","year":"2010","unstructured":"Otter M, Schrander-Stumpel CTRM, Curfs LMG (2010) Triple X syndrome: a review of the literature. Eur J Human Genetics: EJHG 18(3):265\u2013271","journal-title":"Eur J Human Genetics: EJHG"},{"key":"2860_CR41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.clim.2016.04.002","volume":"168","author":"VM Harris","year":"2016","unstructured":"Harris VM et al (2016) Klinefelter\u2019s syndrome (47, XXY) is in excess among men with Sjogren\u2019s syndrome. Clin Immunol 168:25\u201329","journal-title":"Clin Immunol"},{"issue":"4","key":"2860_CR42","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1111\/j.1365-2826.2009.01831.x","volume":"21","author":"AP Arnold","year":"2009","unstructured":"Arnold AP (2009) Mouse models for evaluating sex chromosome effects that cause sex differences in non-gonadal tissues. J Neuroendocrinol 21(4):377\u2013386","journal-title":"J Neuroendocrinol"},{"issue":"20","key":"2860_CR43","doi-asserted-by":"publisher","first-page":"9005","DOI":"10.1523\/JNEUROSCI.22-20-09005.2002","volume":"22","author":"GJ De Vries","year":"2002","unstructured":"De Vries GJ et al (2002) A model system for study of sex chromosome effects on sexually dimorphic neural and behavioral traits. J Neurosci 22(20):9005\u20139014","journal-title":"J Neurosci"},{"issue":"3","key":"2860_CR44","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1242\/dev.109.3.635","volume":"109","author":"R Lovell-Badge","year":"1990","unstructured":"Lovell-Badge R, Robertson E (1990) XY female mice resulting from a heritable mutation in the primary testis-determining gene. Tdy Develop 109(3):635\u2013646","journal-title":"Tdy Develop"},{"issue":"4","key":"2860_CR45","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1093\/hmg\/7.4.715","volume":"7","author":"SK Mahadevaiah","year":"1998","unstructured":"Mahadevaiah SK et al (1998) Mouse homologues of the human AZF candidate gene RBM are expressed in spermatogonia and spermatids, and map to a Y chromosome deletion interval associated with a high incidence of sperm abnormalities. Hum Mol Genet 7(4):715\u2013727","journal-title":"Hum Mol Genet"},{"issue":"1","key":"2860_CR46","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0306-4522(02)00554-7","volume":"116","author":"JA Markham","year":"2003","unstructured":"Markham JA et al (2003) Sex differences in mouse cortical thickness are independent of the complement of sex chromosomes. Neuroscience 116(1):71\u201375","journal-title":"Neuroscience"},{"issue":"3","key":"2860_CR47","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.1210\/en.2003-1219","volume":"145","author":"CK Wagner","year":"2004","unstructured":"Wagner CK et al (2004) Neonatal mice possessing an Sry transgene show a masculinized pattern of progesterone receptor expression in the brain independent of sex chromosome status. Endocrinology 145(3):1046\u20131049","journal-title":"Endocrinology"},{"issue":"1","key":"2860_CR48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yfrne.2008.11.001","volume":"30","author":"AP Arnold","year":"2009","unstructured":"Arnold AP, Chen X (2009) What does the \u201cfour core genotypes\u201d mouse model tell us about sex differences in the brain and other tissues? Front Neuroendocrinol 30(1):1\u20139","journal-title":"Front Neuroendocrinol"},{"issue":"10","key":"2860_CR49","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1038\/nn922","volume":"5","author":"LL Carruth","year":"2002","unstructured":"Carruth LL, Reisert I, Arnold AP (2002) Sex chromosome genes directly affect brain sexual differentiation. Nat Neurosci 5(10):933\u2013934","journal-title":"Nat Neurosci"},{"issue":"1","key":"2860_CR50","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.yhbeh.2007.09.003","volume":"53","author":"L Gioiosa","year":"2008","unstructured":"Gioiosa L et al (2008) Sex chromosome complement affects nociception in tests of acute and chronic exposure to morphine in mice. Horm Behav 53(1):124\u2013130","journal-title":"Horm Behav"},{"issue":"2","key":"2860_CR51","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1002\/dneu.20581","volume":"68","author":"X Chen","year":"2008","unstructured":"Chen X et al (2008) Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol 68(2):265\u2013273","journal-title":"Dev Neurobiol"},{"issue":"23","key":"2860_CR52","doi-asserted-by":"publisher","first-page":"3921","DOI":"10.1242\/dev.048983","volume":"137","author":"K Kashimada","year":"2010","unstructured":"Kashimada K, Koopman P (2010) <em>Sry<\/em>: the master switch in mammalian sex determination. Development 137(23):3921\u20133930","journal-title":"Development"},{"key":"2860_CR53","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1186\/s13104-015-0986-2","volume":"8","author":"Y Itoh","year":"2015","unstructured":"Itoh Y et al (2015) Four core genotypes mouse model: localization of the Sry transgene and bioassay for testicular hormone levels. BMC Res Notes 8:69","journal-title":"BMC Res Notes"},{"issue":"1","key":"2860_CR54","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1186\/s12864-017-3608-7","volume":"18","author":"JL Bundy","year":"2017","unstructured":"Bundy JL, Vied C, Nowakowski RS (2017) Sex differences in the molecular signature of the developing mouse hippocampus. BMC Genomics 18(1):237","journal-title":"BMC Genomics"},{"key":"2860_CR55","doi-asserted-by":"crossref","unstructured":"Chucair-Elliott AJ, et al., 2019. Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies. GeroScience","DOI":"10.1007\/s11357-019-00090-2"},{"issue":"1","key":"2860_CR56","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13072-019-0306-5","volume":"12","author":"N Hadad","year":"2019","unstructured":"Hadad N et al (2019) Early-life DNA methylation profiles are indicative of age-related transcriptome changes. Epigenetics Chromatin 12(1):58","journal-title":"Epigenetics Chromatin"},{"issue":"13","key":"2860_CR57","doi-asserted-by":"publisher","first-page":"2696","DOI":"10.1002\/cne.23989","volume":"524","author":"C Vied","year":"2016","unstructured":"Vied C et al (2016) Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests a basis for sex-specific susceptibility and severity of neurological disorders. J Comp Neurol 524(13):2696\u20132710","journal-title":"J Comp Neurol"},{"issue":"3","key":"2860_CR58","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1005079","volume":"11","author":"JB Berletch","year":"2015","unstructured":"Berletch JB et al (2015) Escape from X Inactivation Varies in Mouse Tissues. PLoS Genet 11(3):e1005079","journal-title":"PLoS Genet"},{"issue":"1","key":"2860_CR59","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s13059-015-0733-y","volume":"16","author":"A Cerase","year":"2015","unstructured":"Cerase A et al (2015) Xist localization and function: new insights from multiple levels. Genome Biol 16(1):166","journal-title":"Genome Biol"},{"issue":"4","key":"2860_CR60","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/jb\/mvy106","volume":"165","author":"H Mizukami","year":"2019","unstructured":"Mizukami H et al (2019) KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts. J Biochem 165(4):335\u2013342","journal-title":"J Biochem"},{"issue":"1","key":"2860_CR61","doi-asserted-by":"publisher","first-page":"15041","DOI":"10.1038\/srep15041","volume":"5","author":"C Ramathal","year":"2015","unstructured":"Ramathal C et al (2015) DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs. Sci Rep 5(1):15041","journal-title":"Sci Rep"},{"issue":"8","key":"2860_CR62","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1038\/nsmb.3432","volume":"24","author":"H-P Chu","year":"2017","unstructured":"Chu H-P et al (2017) PAR-TERRA directs homologous sex chromosome pairing. Nat Struct Mol Biol 24(8):620\u2013631","journal-title":"Nat Struct Mol Biol"},{"issue":"8","key":"2860_CR63","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1101\/gr.092643.109","volume":"19","author":"H Marks","year":"2009","unstructured":"Marks H et al (2009) High-resolution analysis of epigenetic changes associated with X inactivation. Genome Res 19(8):1361\u20131373","journal-title":"Genome Res"},{"issue":"2","key":"2860_CR64","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0959-437X(93)90027-M","volume":"3","author":"PH Tate","year":"1993","unstructured":"Tate PH, Bird AP (1993) Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 3(2):226\u2013231","journal-title":"Curr Opin Genet Dev"},{"issue":"2","key":"2860_CR65","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1038\/561","volume":"19","author":"PL Jones","year":"1998","unstructured":"Jones PL et al (1998) Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Nat Genet 19(2):187\u2013191","journal-title":"Nat Genet"},{"issue":"22","key":"2860_CR66","doi-asserted-by":"publisher","first-page":"12859","DOI":"10.1073\/pnas.2131819100","volume":"100","author":"S Watanabe","year":"2003","unstructured":"Watanabe S et al (2003) Methylated DNA-binding domain 1 and methylpurine-DNA glycosylase link transcriptional repression and DNA repair in chromatin. Proc Natl Acad Sci USA 100(22):12859\u201312864","journal-title":"Proc Natl Acad Sci USA"},{"issue":"26","key":"2860_CR67","doi-asserted-by":"publisher","first-page":"24132","DOI":"10.1074\/jbc.M302283200","volume":"278","author":"N Fujita","year":"2003","unstructured":"Fujita N et al (2003) Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression. J Biol Chem 278(26):24132\u201324138","journal-title":"J Biol Chem"},{"issue":"43","key":"2860_CR68","doi-asserted-by":"publisher","first-page":"40958","DOI":"10.1074\/jbc.M207467200","volume":"277","author":"M Brackertz","year":"2002","unstructured":"Brackertz M et al (2002) Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. J Biol Chem 277(43):40958\u201340966","journal-title":"J Biol Chem"},{"issue":"4","key":"2860_CR69","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/0092-8674(94)90208-9","volume":"77","author":"A Razin","year":"1994","unstructured":"Razin A, Cedar H (1994) DNA methylation and genomic imprinting. Cell 77(4):473\u2013476","journal-title":"Cell"},{"issue":"9","key":"2860_CR70","doi-asserted-by":"publisher","first-page":"2806","DOI":"10.1073\/pnas.81.9.2806","volume":"81","author":"SF Wolf","year":"1984","unstructured":"Wolf SF et al (1984) Methylation of the hypoxanthine phosphoribosyltransferase locus on the human X chromosome: implications for X-chromosome inactivation. Proc Natl Acad Sci 81(9):2806\u20132810","journal-title":"Proc Natl Acad Sci"},{"issue":"21","key":"2860_CR71","doi-asserted-by":"publisher","first-page":"8252","DOI":"10.1073\/pnas.87.21.8252","volume":"87","author":"GP Pfeifer","year":"1990","unstructured":"Pfeifer GP et al (1990) Polymerase Chain Reaction-Aided Genomic Sequencing of an X Chromosome- Linked CpG Island: Methylation Patterns Suggest Clonal Inheritance, CpG Site Autonomy, and an Explanation of Activity State Stability. Proc Natl Acad Sci USA 87(21):8252\u20138256","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2860_CR72","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/BF01233203","volume":"17","author":"MH Bartlett","year":"1991","unstructured":"Bartlett MH et al (1991) DNA methylation of two X chromosome genes in female somatic and embryonal carcinoma cells. Somat Cell Mol Genet 17(1):35\u201347","journal-title":"Somat Cell Mol Genet"},{"issue":"1","key":"2860_CR73","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1093\/nar\/gkj400","volume":"34","author":"T Angrisano","year":"2006","unstructured":"Angrisano T et al (2006) TACC3 mediates the association of MBD2 with histone acetyltransferases and relieves transcriptional repression of methylated promoters. Nucleic Acids Res 34(1):364\u2013372","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"2860_CR74","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1101\/gr.112680.110","volume":"21","author":"AJ Sharp","year":"2011","unstructured":"Sharp AJ et al (2011) DNA methylation profiles of human active and inactive X chromosomes. Genome Res 21(10):1592\u20131600","journal-title":"Genome Res"},{"issue":"5","key":"2860_CR75","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1007\/s11357-019-00090-2","volume":"41","author":"AJ Chucair-Elliott","year":"2019","unstructured":"Chucair-Elliott AJ et al (2019) Tamoxifen induction of Cre recombinase does not cause long-lasting or sexually divergent responses in the CNS epigenome or transcriptome: implications for the design of aging studies. Geroscience 41(5):691\u2013708","journal-title":"Geroscience"},{"issue":"36","key":"2860_CR76","doi-asserted-by":"publisher","first-page":"E7526","DOI":"10.1073\/pnas.1703087114","volume":"114","author":"DM Jeziorska","year":"2017","unstructured":"Jeziorska DM et al (2017) DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease. Proc Natl Acad Sci 114(36):E7526\u2013E7535","journal-title":"Proc Natl Acad Sci"},{"issue":"1","key":"2860_CR77","doi-asserted-by":"publisher","first-page":"10138","DOI":"10.1038\/s41598-018-28356-3","volume":"8","author":"CG Duncan","year":"2018","unstructured":"Duncan CG et al (2018) Dosage compensation and DNA methylation landscape of the X chromosome in mouse liver. Sci Rep 8(1):10138","journal-title":"Sci Rep"},{"issue":"2","key":"2860_CR78","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.molcel.2014.12.006","volume":"57","author":"JT Kung","year":"2015","unstructured":"Kung JT et al (2015) Locus-specific targeting to the X chromosome revealed by the RNA interactome of CTCF. Mol Cell 57(2):361\u2013375","journal-title":"Mol Cell"},{"issue":"1\u20134","key":"2860_CR79","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1159\/000014969","volume":"80","author":"MF Lyon","year":"1998","unstructured":"Lyon MF (1998) X-chromosome inactivation: a repeat hypothesis. Cytogenet Cell Genet 80(1\u20134):133\u2013137","journal-title":"Cytogenet Cell Genet"},{"issue":"1","key":"2860_CR80","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1038\/s41467-020-15520-5","volume":"11","author":"AG Diehl","year":"2020","unstructured":"Diehl AG, Ouyang N, Boyle AP (2020) Transposable elements contribute to cell and species-specific chromatin looping and gene regulation in mammalian genomes. Nat Commun 11(1):1796","journal-title":"Nat Commun"},{"key":"2860_CR81","doi-asserted-by":"crossref","unstructured":"von Mering C, et al., 2005 STRING: known and predicted protein-protein associations, integrated and transferred across organisms. Nucleic Acids Res 33(Database issue): D433\u20137.","DOI":"10.1093\/nar\/gki005"},{"issue":"7818","key":"2860_CR82","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41586-020-2093-3","volume":"583","author":"DU Gorkin","year":"2020","unstructured":"Gorkin DU et al (2020) An atlas of dynamic chromatin landscapes in mouse fetal development. Nature 583(7818):744\u2013751","journal-title":"Nature"},{"issue":"6146","key":"2860_CR83","doi-asserted-by":"publisher","first-page":"1237905","DOI":"10.1126\/science.1237905","volume":"341","author":"R Lister","year":"2013","unstructured":"Lister R et al (2013) Global epigenomic reconfiguration during mammalian brain development. Science 341(6146):1237905","journal-title":"Science"},{"key":"2860_CR84","doi-asserted-by":"crossref","unstructured":"Tran N, Broun A, Ge K, 2020 Lysine Demethylase KDM6A in Differentiation, Development, and Cancer. Mol Cell Biol 40(20).","DOI":"10.1128\/MCB.00341-20"},{"issue":"4","key":"2860_CR85","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1016\/j.celrep.2013.02.030","volume":"3","author":"S Outchkourov Nikolay","year":"2013","unstructured":"Outchkourov Nikolay S et al (2013) Balancing of Histone H3K4 Methylation States by the Kdm5c\/SMCX Histone Demethylase Modulates Promoter and Enhancer Function. Cell Rep 3(4):1071\u20131079","journal-title":"Cell Rep"},{"issue":"7","key":"2860_CR86","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.celrep.2015.07.024","volume":"12","author":"T Maurano Matthew","year":"2015","unstructured":"Maurano Matthew T et al (2015) Role of DNA Methylation in Modulating Transcription Factor Occupancy. Cell Rep 12(7):1184\u20131195","journal-title":"Cell Rep"},{"issue":"11","key":"2860_CR87","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.15252\/embj.201796812","volume":"36","author":"A Teissandier","year":"2017","unstructured":"Teissandier A, Bourc\u2019his D (2017) Gene body DNA methylation conspires with H3K36me3 to preclude aberrant transcription. Embo j 36(11):1471\u20131473","journal-title":"Embo j"},{"issue":"7","key":"2860_CR88","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1101\/gr.245027.118","volume":"29","author":"E Barros de Andrade","year":"2019","unstructured":"Barros de Andrade E, Sousa L et al (2019) Kinetics of Xist-induced gene silencing can be predicted from combinations of epigenetic and genomic features. Genome Res 29(7):1087\u20131099","journal-title":"Genome Res"},{"key":"2860_CR89","doi-asserted-by":"crossref","unstructured":"Bae S, Lesch BJ, 2020 H3K4me1 Distribution Predicts Transcription State and Poising at Promoters. Frontiers in Cell and Developmental Biology, 8.","DOI":"10.3389\/fcell.2020.00289"},{"issue":"1","key":"2860_CR90","doi-asserted-by":"publisher","first-page":"2851","DOI":"10.1038\/s41467-019-10704-0","volume":"10","author":"I Jaric","year":"2019","unstructured":"Jaric I et al (2019) Chromatin organization in the female mouse brain fluctuates across the oestrous cycle. Nat Commun 10(1):2851","journal-title":"Nat Commun"},{"issue":"D1","key":"2860_CR91","doi-asserted-by":"publisher","first-page":"D165","DOI":"10.1093\/nar\/gkab1113","volume":"50","author":"JA Castro-Mondragon","year":"2022","unstructured":"Castro-Mondragon JA et al (2022) JASPAR 2022: the 9th release of the open-access database of transcription factor binding profiles. Nucleic Acids Res 50(D1):D165\u2013D173","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"2860_CR92","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1007\/s00268-010-0951-0","volume":"35","author":"SM Weakley","year":"2011","unstructured":"Weakley SM et al (2011) Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg 35(8):1751\u20131756","journal-title":"World J Surg"},{"issue":"2","key":"2860_CR93","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.ajhg.2015.07.004","volume":"97","author":"L Snijders Blok","year":"2015","unstructured":"Snijders Blok L et al (2015) Mutations in DDX3X Are a Common Cause of Unexplained Intellectual Disability with Gender-Specific Effects on Wnt Signaling. Am J Hum Genet 97(2):343\u2013352","journal-title":"Am J Hum Genet"},{"key":"2860_CR94","doi-asserted-by":"crossref","unstructured":"Cortes LR, Cisternas CD, Forger NG 2019 Does Gender Leave an Epigenetic Imprint on the Brain? Front Neurosci 13(173).","DOI":"10.3389\/fnins.2019.00173"},{"issue":"1","key":"2860_CR95","first-page":"3","volume":"37","author":"RA Davey","year":"2016","unstructured":"Davey RA, Grossmann M (2016) Androgen Receptor Structure, Function and Biology: From Bench to Bedside. Clin Biochem Rev 37(1):3\u201315","journal-title":"Clin Biochem Rev"},{"issue":"1","key":"2860_CR96","first-page":"46","volume":"22","author":"S Atwi","year":"2016","unstructured":"Atwi S et al (2016) Androgen Modulation of Hippocampal Structure and Function. Neurosci Rev J Bring Neurobiol Neurol Psychiatry 22(1):46\u201360","journal-title":"Neurosci Rev J Bring Neurobiol Neurol Psychiatry"},{"issue":"36","key":"2860_CR97","doi-asserted-by":"publisher","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","volume":"34","author":"Y Zhang","year":"2014","unstructured":"Zhang Y et al (2014) An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex. J Neurosci 34(36):11929","journal-title":"J Neurosci"},{"key":"2860_CR98","doi-asserted-by":"crossref","unstructured":"T Kawasaki T Kawai 2014 Toll-like receptor signaling pathways Front Immunol 5 461","DOI":"10.3389\/fimmu.2014.00461"},{"issue":"7","key":"2860_CR99","doi-asserted-by":"publisher","DOI":"10.15252\/msb.20209610","volume":"16","author":"F Hikmet","year":"2020","unstructured":"Hikmet F et al (2020) The protein expression profile of ACE2 in human tissues. Mol Syst Biol 16(7):e9610","journal-title":"Mol Syst Biol"},{"issue":"7818","key":"2860_CR100","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","volume":"583","author":"JE Moore","year":"2020","unstructured":"Moore JE et al (2020) Expanded encyclopaedias of DNA elements in the human and mouse genomes. Nature 583(7818):699\u2013710","journal-title":"Nature"},{"key":"2860_CR101","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/s13072-016-0080-6","volume":"9","author":"N Hadad","year":"2016","unstructured":"Hadad N et al (2016) Absence of genomic hypomethylation or regulation of cytosine-modifying enzymes with aging in male and female mice. Epigenetics Chromatin 9:30","journal-title":"Epigenetics Chromatin"},{"issue":"9","key":"2860_CR102","doi-asserted-by":"publisher","first-page":"1397","DOI":"10.1002\/glia.23154","volume":"65","author":"T Blank","year":"2017","unstructured":"Blank T, Prinz M (2017) Type I interferon pathway in CNS homeostasis and neurological disorders. Glia 65(9):1397\u20131406","journal-title":"Glia"},{"issue":"4","key":"2860_CR103","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1172\/JCI133737","volume":"130","author":"ER Roy","year":"2020","unstructured":"Roy ER et al (2020) Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Investig 130(4):1912\u20131930","journal-title":"J Clin Investig"},{"issue":"7034","key":"2860_CR104","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1038\/nature03464","volume":"434","author":"K Honda","year":"2005","unstructured":"Honda K et al (2005) IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434(7034):772\u2013777","journal-title":"Nature"},{"issue":"5","key":"2860_CR105","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.4049\/jimmunol.1100963","volume":"187","author":"X-Y Liu","year":"2011","unstructured":"Liu X-Y et al (2011) IFN-Induced TPR Protein IFIT3 Potentiates Antiviral Signaling by Bridging MAVS and TBK1. J Immunol 187(5):2559","journal-title":"J Immunol"},{"issue":"1","key":"2860_CR106","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s12031-012-9783-8","volume":"48","author":"HD VanGuilder Starkey","year":"2012","unstructured":"VanGuilder Starkey HD et al (2012) Neuroglial expression of the MHCI pathway and PirB receptor is upregulated in the hippocampus with advanced aging. J Mol Neurosci MN 48(1):111\u2013126","journal-title":"J Mol Neurosci MN"},{"issue":"1","key":"2860_CR107","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1093\/gerona\/glv232","volume":"72","author":"CA Mangold","year":"2017","unstructured":"Mangold CA et al (2017) CNS-wide Sexually Dimorphic Induction of the Major Histocompatibility Complex 1 Pathway With Aging. J Gerontol A Biol Sci Med Sci 72(1):16\u201329","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"2860_CR108","doi-asserted-by":"publisher","first-page":"1342","DOI":"10.1111\/acel.12681","volume":"16","author":"DR Masser","year":"2017","unstructured":"Masser DR et al (2017) Sexually divergent DNA methylation patterns with hippocampal aging. Aging Cell 16(6):1342\u20131352","journal-title":"Aging Cell"},{"key":"2860_CR109","doi-asserted-by":"crossref","unstructured":"Wu T, et al., 2021 ClusterProfiler 4.0: A universal enrichment tool for interpreting omics data. The Innovation, 2(3).","DOI":"10.1016\/j.xinn.2021.100141"},{"issue":"1","key":"2860_CR110","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s42003-020-01418-x","volume":"3","author":"AJ Chucair-Elliott","year":"2020","unstructured":"Chucair-Elliott AJ et al (2020) Inducible cell-specific mouse models for paired epigenetic and transcriptomic studies of microglia and astroglia. Commun Biol 3(1):693","journal-title":"Commun Biol"},{"issue":"7","key":"2860_CR111","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1523\/JNEUROSCI.5372-11.2012","volume":"32","author":"MM McCarthy","year":"2012","unstructured":"McCarthy MM et al (2012) Sex differences in the brain: the not so inconvenient truth. J Neurosci 32(7):2241\u20132247","journal-title":"J Neurosci"},{"issue":"8","key":"2860_CR112","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1186\/jbiol95","volume":"7","author":"B Panning","year":"2008","unstructured":"Panning B (2008) X-chromosome inactivation: the molecular basis of silencing. J Biol 7(8):30","journal-title":"J Biol"},{"key":"2860_CR113","doi-asserted-by":"publisher","first-page":"219","DOI":"10.3389\/fcell.2019.00219","volume":"7","author":"H Fang","year":"2019","unstructured":"Fang H, Disteche CM, Berletch JB (2019) X Inactivation and Escape: Epigenetic and Structural Features. Front Cell Develop Biol 7:219\u2013219","journal-title":"Front Cell Develop Biol"},{"issue":"7031","key":"2860_CR114","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/nature03479","volume":"434","author":"L Carrel","year":"2005","unstructured":"Carrel L, Willard HF (2005) X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature 434(7031):400\u2013404","journal-title":"Nature"},{"issue":"2","key":"2860_CR115","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/s00439-011-1011-z","volume":"130","author":"JB Berletch","year":"2011","unstructured":"Berletch JB et al (2011) Genes that escape from X inactivation. Hum Genet 130(2):237\u2013245","journal-title":"Hum Genet"},{"issue":"1","key":"2860_CR116","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1186\/s10020-020-00256-1","volume":"26","author":"MJ Mousavi","year":"2020","unstructured":"Mousavi MJ, Mahmoudi M, Ghotloo S (2020) Escape from X chromosome inactivation and female bias of autoimmune diseases. Mol Med 26(1):127","journal-title":"Mol Med"},{"issue":"3","key":"2860_CR117","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.3390\/ijms22031114","volume":"22","author":"A Youness","year":"2021","unstructured":"Youness A, Miquel C-H, Gu\u00e9ry J-C (2021) Escape from X Chromosome Inactivation and the Female Predominance in Autoimmune Diseases. Int J Mol Sci 22(3):1114","journal-title":"Int J Mol Sci"},{"key":"2860_CR118","doi-asserted-by":"publisher","first-page":"1368","DOI":"10.3389\/fgene.2019.01368","volume":"10","author":"VP Bajic","year":"2020","unstructured":"Bajic VP et al (2020) The X Files: \u201cThe Mystery of X Chromosome Instability in Alzheimer\u2019s Disease.\u201d Front Genet 10:1368\u20131368","journal-title":"Front Genet"},{"issue":"6","key":"2860_CR119","doi-asserted-by":"publisher","first-page":"956","DOI":"10.1016\/j.cell.2010.04.042","volume":"141","author":"JC Chow","year":"2010","unstructured":"Chow JC et al (2010) LINE-1 Activity in Facultative Heterochromatin Formation during X Chromosome Inactivation. Cell 141(6):956\u2013969","journal-title":"Cell"},{"issue":"12","key":"2860_CR120","doi-asserted-by":"publisher","first-page":"6634","DOI":"10.1073\/pnas.97.12.6634","volume":"97","author":"JA Bailey","year":"2000","unstructured":"Bailey JA et al (2000) Molecular evidence for a relationship between LINE-1 elements and X chromosome inactivation: The Lyon repeat hypothesis. Proc Natl Acad Sci 97(12):6634","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"2860_CR121","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1093\/hmg\/ddt513","volume":"23","author":"AM Cotton","year":"2014","unstructured":"Cotton AM et al (2014) Spread of X-chromosome inactivation into autosomal sequences: role for DNA elements, chromatin features and chromosomal domains. Hum Mol Genet 23(5):1211\u20131223","journal-title":"Hum Mol Genet"},{"key":"2860_CR122","doi-asserted-by":"crossref","unstructured":"Kato A, et al., 2013 Female hippocampal estrogens have a significant correlation with cyclic fluctuation of hippocampal spines. Front Neural Circuits 7.","DOI":"10.3389\/fncir.2013.00149"},{"issue":"15","key":"2860_CR123","doi-asserted-by":"publisher","first-page":"3360","DOI":"10.1002\/cne.24282","volume":"525","author":"LM DiCarlo","year":"2017","unstructured":"DiCarlo LM, Vied C, Nowakowski RS (2017) The stability of the transcriptome during the estrous cycle in four regions of the mouse brain. J Comp Neurol 525(15):3360\u20133387","journal-title":"J Comp Neurol"},{"issue":"9","key":"2860_CR124","doi-asserted-by":"publisher","first-page":"3852","DOI":"10.1172\/JCI126250","volume":"129","author":"Y Itoh","year":"2019","unstructured":"Itoh Y et al (2019) The X-linked histone demethylase Kdm6a in CD4+ T lymphocytes modulates autoimmunity. J Clin Investig 129(9):3852\u20133863","journal-title":"J Clin Investig"},{"key":"2860_CR125","doi-asserted-by":"crossref","unstructured":"Doss PMIA., et al., 2021 Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity. Cell Reports, 34(10).","DOI":"10.1016\/j.celrep.2021.108833"},{"issue":"11","key":"2860_CR126","doi-asserted-by":"publisher","first-page":"5688","DOI":"10.1172\/JCI140223","volume":"130","author":"JC Link","year":"2020","unstructured":"Link JC et al (2020) X chromosome dosage of histone demethylase KDM5C determines sex differences in adiposity. J Clin Invest 130(11):5688\u20135702","journal-title":"J Clin Invest"},{"key":"2860_CR127","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111425","volume":"194","author":"VA Ansere","year":"2021","unstructured":"Ansere VA et al (2021) Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion. Mech Ageing Dev 194:111425","journal-title":"Mech Ageing Dev"},{"issue":"1","key":"2860_CR128","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/1756-8935-6-33","volume":"6","author":"DR Masser","year":"2013","unstructured":"Masser DR, Berg AS, Freeman WM (2013) Focused, high accuracy 5-methylcytosine quantitation with base resolution by benchtop next-generation sequencing. Epigenetics Chromatin 6(1):33\u201333","journal-title":"Epigenetics Chromatin"},{"issue":"4","key":"2860_CR129","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s11357-016-9930-1","volume":"38","author":"DR Masser","year":"2016","unstructured":"Masser DR et al (2016) Loss of the antioxidant enzyme CuZnSOD (Sod1) mimics an age-related increase in absolute mitochondrial DNA copy number in the skeletal muscle. Age (Dordr) 38(4):323\u2013333","journal-title":"Age (Dordr)"},{"key":"2860_CR130","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nmeth.4184","volume":"14","author":"JT Simpson","year":"2017","unstructured":"Simpson JT et al (2017) Detecting DNA cytosine methylation using nanopore sequencing. Nat Methods 14:407","journal-title":"Nat Methods"},{"issue":"11","key":"2860_CR131","doi-asserted-by":"publisher","first-page":"1311","DOI":"10.1093\/gerona\/glu091","volume":"69","author":"DR Masser","year":"2014","unstructured":"Masser DR et al (2014) Hippocampal subregions exhibit both distinct and shared transcriptomic responses to aging and nonneurodegenerative cognitive decline. J Gerontol A Biol Sci Med Sci 69(11):1311\u20131324","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"10","key":"2860_CR132","doi-asserted-by":"publisher","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","volume":"11","author":"S Anders","year":"2010","unstructured":"Anders S, Huber W (2010) Differential expression analysis for sequence count data. Genome Biol 11(10):R106","journal-title":"Genome Biol"},{"issue":"15","key":"2860_CR133","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","volume":"30","author":"AM Bolger","year":"2014","unstructured":"Bolger AM, Lohse M, Usadel B (2014) Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics 30(15):2114\u20132120","journal-title":"Bioinformatics"},{"issue":"11","key":"2860_CR134","doi-asserted-by":"publisher","first-page":"1571","DOI":"10.1093\/bioinformatics\/btr167","volume":"27","author":"F Krueger","year":"2011","unstructured":"Krueger F, Andrews SR (2011) Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications. Bioinformatics 27(11):1571\u20131572","journal-title":"Bioinformatics"},{"issue":"4","key":"2860_CR135","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nmeth.1923","volume":"9","author":"B Langmead","year":"2012","unstructured":"Langmead B, Salzberg SL (2012) Fast gapped-read alignment with Bowtie 2. Nat Methods 9(4):357\u2013359","journal-title":"Nat Methods"},{"issue":"10","key":"2860_CR136","doi-asserted-by":"publisher","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","volume":"13","author":"A Akalin","year":"2012","unstructured":"Akalin A et al (2012) methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles. Genome Biol 13(10):R87","journal-title":"Genome Biol"},{"issue":"W1","key":"2860_CR137","doi-asserted-by":"publisher","first-page":"W199","DOI":"10.1093\/nar\/gkz401","volume":"47","author":"Y Liao","year":"2019","unstructured":"Liao Y et al (2019) WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs. Nucleic Acids Res 47(W1):W199-w205","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"2860_CR138","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1186\/s12864-018-4625-x","volume":"19","author":"Z Gu","year":"2018","unstructured":"Gu Z et al (2018) EnrichedHeatmap: an R\/Bioconductor package for comprehensive visualization of genomic signal associations. BMC Genomics 19(1):234","journal-title":"BMC Genomics"},{"key":"2860_CR139","doi-asserted-by":"crossref","unstructured":"Karolchik D, et al., 2004 The UCSC Table Browser data retrieval tool. Nucleic Acids Res 32(Database issue):D493\u20136.","DOI":"10.1093\/nar\/gkh103"},{"issue":"D1","key":"2860_CR140","doi-asserted-by":"publisher","first-page":"D1115","DOI":"10.1093\/nar\/gkab959","volume":"50","author":"BT Lee","year":"2022","unstructured":"Lee BT et al (2022) The UCSC Genome Browser database: 2022 update. Nucleic Acids Res 50(D1):D1115\u2013D1122","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"2860_CR141","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","volume":"26","author":"AR Quinlan","year":"2010","unstructured":"Quinlan AR, Hall IM (2010) BEDTools: a flexible suite of utilities for comparing genomic features. Bioinformatics 26(6):841\u2013842","journal-title":"Bioinformatics"},{"issue":"1","key":"2860_CR142","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1186\/s12864-018-4630-0","volume":"19","author":"LT Dang","year":"2018","unstructured":"Dang LT et al (2018) TrawlerWeb: an online de novo motif discovery tool for next-generation sequencing datasets. BMC Genomics 19(1):238","journal-title":"BMC Genomics"},{"key":"2860_CR143","unstructured":"Oliveros JC, VENNY. 2007 An interactive tool for comparing lists with Venn Diagrams"},{"key":"2860_CR144","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3233\/DS-210032","volume":"4","author":"T Hulsen","year":"2021","unstructured":"Hulsen T (2021) BioVenn&nbsp;\u2013 an R and Python package for the comparison and visualization of biological lists using area-proportional Venn diagrams. Data Sci 4:51\u201361","journal-title":"Data Sci"},{"key":"2860_CR145","doi-asserted-by":"crossref","unstructured":"Mishra GP, et al., 2020 BedSect: An Integrated Web Server Application to Perform Intersection, Visualization, and Functional Annotation of Genomic Regions From Multiple Datasets. Front Genetics 11.","DOI":"10.3389\/fgene.2020.00003"},{"key":"2860_CR146","volume-title":"ggplot2: Elegant Graphics for Data Analysis","author":"H Wickman","year":"2016","unstructured":"Wickman H (2016) ggplot2: Elegant Graphics for Data Analysis. Springer-Verlag, New York"},{"key":"2860_CR147","doi-asserted-by":"crossref","unstructured":"Wu T, et al., 2021 ClusterProfiler 4.0 A universal enrichment tool for interpreting omics data. The Innovation, 2(3): 100141.","DOI":"10.1016\/j.xinn.2021.100141"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02860-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-02860-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02860-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T19:43:45Z","timestamp":1744141425000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-02860-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,20]]},"references-count":147,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["2860"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-02860-0","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.09.01.458115","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,20]]},"assertion":[{"value":"27 September 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}