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The Animal Ethics Committee approved all procedures in this study involving animals of the Universidade Federal de Santa Catarina (CEUA\/UFSC, protocol number 3914220319). All of the experimental procedures were conducted according to the guidelines of CONCEA and CEUA\/UFSC, based on the principles of the 3Rs (Replacement, Reduction, and Refinement).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Code Availability"}},{"value":"The authors declare that they have no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}