{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T23:14:12Z","timestamp":1783206852668,"version":"3.54.6"},"reference-count":113,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T00:00:00Z","timestamp":1654300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG058884"],"award-info":[{"award-number":["R01AG058884"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA041746"],"award-info":[{"award-number":["R01DA041746"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1007\/s12035-022-02890-8","type":"journal-article","created":{"date-parts":[[2022,6,4]],"date-time":"2022-06-04T17:03:06Z","timestamp":1654362186000},"page":"4966-4986","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["HIV Promotes Neurocognitive Impairment by Damaging the Hippocampal Microvessels"],"prefix":"10.1007","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9969-8642","authenticated-orcid":false,"given":"Adhikarimayum Lakhikumar","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaixing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongxiu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guetchyn","family":"Millien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1493-8051","authenticated-orcid":false,"given":"Mudit","family":"Tyagi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarin","family":"Hongpaisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,4]]},"reference":[{"issue":"11","key":"2890_CR1","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1016\/S1473-3099(13)70269-X","volume":"13","author":"DBBM Clifford","year":"2013","unstructured":"Clifford DBBM (2013) Ances, HIV-associated neurocognitive disorder. Lancet Infect Dis 13(11):976\u2013986","journal-title":"Lancet Infect Dis"},{"key":"2890_CR2","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3389\/fcvm.2018.00185","volume":"5","author":"AR Anand","year":"2018","unstructured":"Anand AR, Rachel GD (2018) Parthasarathy HIV proteins and endothelial dysfunction implications in cardiovascular disease. Front Cardiovasc Med 5:185","journal-title":"Front Cardiovasc Med"},{"issue":"5","key":"2890_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1007\/s11883-017-0652-3","volume":"19","author":"RP Barnes","year":"2017","unstructured":"Barnes RP, Lacson JC, Bahrami H (2017) HIV infection and risk of cardiovascular diseases beyond coronary artery disease. Curr Atheroscler Rep 19(5):20","journal-title":"Curr Atheroscler Rep"},{"issue":"5","key":"2890_CR4","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1007\/s13365-018-0706-5","volume":"25","author":"LABJ Cysique","year":"2019","unstructured":"Cysique LABJ (2019) Brew, Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm. J Neurovirol 25(5):710\u2013721","journal-title":"J Neurovirol"},{"issue":"5","key":"2890_CR5","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1212\/WNL.0b013e31820a0cfc","volume":"76","author":"BA Ovbiagele","year":"2011","unstructured":"Ovbiagele BA (2011) Nath, Increasing incidence of ischemic stroke in patients with HIV infection. Neurology 76(5):444\u2013450","journal-title":"Neurology"},{"key":"2890_CR6","doi-asserted-by":"publisher","first-page":"857484","DOI":"10.4061\/2011\/857484","volume":"2011","author":"MIM Di Napoli","year":"2011","unstructured":"Di Napoli MIM (2011) Shah, Neuroinflammation and cerebrovascular disease in old age: a translational medicine perspective. J Aging Res 2011:857484","journal-title":"J Aging Res"},{"issue":"4","key":"2890_CR7","doi-asserted-by":"publisher","first-page":"e0215507","DOI":"10.1371\/journal.pone.0215507","volume":"14","author":"M Masia","year":"2019","unstructured":"Masia M et al (2019) Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers A study of the Spanish CoRIS cohort, 2004\u20132015. PLoS One 14(4):e0215507","journal-title":"PLoS One"},{"issue":"10","key":"2890_CR8","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1586\/erc.09.72","volume":"7","author":"MRJR Dobbs","year":"2009","unstructured":"Dobbs MRJR (2009) Berger, Stroke in HIV infection and AIDS. Expert Rev Cardiovasc Ther 7(10):1263\u20131271","journal-title":"Expert Rev Cardiovasc Ther"},{"issue":"3","key":"2890_CR9","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000335300","volume":"33","author":"S Sen","year":"2012","unstructured":"Sen S et al (2012) Recent developments regarding human immunodeficiency virus infection and stroke. Cerebrovasc Dis 33(3):209\u2013218","journal-title":"Cerebrovasc Dis"},{"issue":"7","key":"2890_CR10","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1111\/micc.12145","volume":"21","author":"JN Silva","year":"2014","unstructured":"Silva JN et al (2014) Chronic central nervous system expression of HIV-1 Tat leads to accelerated rarefaction of neocortical capillaries and loss of red blood cell velocity heterogeneity. Microcirculation 21(7):664\u2013676","journal-title":"Microcirculation"},{"issue":"5","key":"2890_CR11","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.amjhyper.2005.11.010","volume":"19","author":"TF Antonios","year":"2006","unstructured":"Antonios TF (2006) Microvascular rarefaction in hypertension\u2013reversal or over-correction by treatment? Am J Hypertens 19(5):484\u2013485","journal-title":"Am J Hypertens"},{"issue":"Spec No 1","key":"2890_CR12","first-page":"37","volume":"58","author":"HA Boudier","year":"1999","unstructured":"Boudier HA (1999) Arteriolar and capillary remodelling in hypertension. Drugs 58(Spec No 1):37\u201340","journal-title":"Drugs"},{"issue":"1","key":"2890_CR13","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1111\/j.1365-2990.2010.01139.x","volume":"37","author":"WRCR Brown","year":"2011","unstructured":"Brown WRCR (2011) Thore, Review: cerebral microvascular pathology in ageing and neurodegeneration. Neuropathol Appl Neurobiol 37(1):56\u201374","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"34","key":"2890_CR14","doi-asserted-by":"publisher","first-page":"12474","DOI":"10.1073\/pnas.0805350105","volume":"105","author":"AM Troen","year":"2008","unstructured":"Troen AM et al (2008) B-vitamin deficiency causes hyperhomocysteinemia and vascular cognitive impairment in mice. Proc Natl Acad Sci U S A 105(34):12474\u201312479","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2890_CR15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1186\/s12916-014-0206-2","volume":"12","author":"JKA Attems","year":"2014","unstructured":"Attems JKA (2014) Jellinger, The overlap between vascular disease and Alzheimer\u2019s disease\u2013lessons from pathology. BMC Med 12:206","journal-title":"BMC Med"},{"issue":"3","key":"2890_CR16","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1161\/STROKEAHA.110.595082","volume":"42","author":"Z Arvanitakis","year":"2011","unstructured":"Arvanitakis Z et al (2011) Microinfarct pathology, dementia, and cognitive systems. Stroke 42(3):722\u2013727","journal-title":"Stroke"},{"key":"2890_CR17","doi-asserted-by":"publisher","first-page":"585218","DOI":"10.3389\/fnagi.2020.585218","volume":"12","author":"LK Hill","year":"2020","unstructured":"Hill LK et al (2020) Detection of cerebrovascular loss in the normal aging C57BL\/6 mouse brain using in vivo contrast-enhanced magnetic resonance angiography. Front Aging Neurosci 12:585218","journal-title":"Front Aging Neurosci"},{"issue":"11","key":"2890_CR18","doi-asserted-by":"publisher","first-page":"e1501","DOI":"10.1212\/WNL.0000000000011537","volume":"96","author":"M Paradise","year":"2021","unstructured":"Paradise M et al (2021) Association of dilated perivascular spaces with cognitive decline and incident dementia. Neurology 96(11):e1501\u2013e1511","journal-title":"Neurology"},{"issue":"1","key":"2890_CR19","doi-asserted-by":"publisher","first-page":"247","DOI":"10.3233\/JAD-190527","volume":"72","author":"D Smeijer","year":"2019","unstructured":"Smeijer D, Ikram MK, Hilal S (2019) Enlarged perivascular spaces and dementia: a systematic review. J Alzheimers Dis 72(1):247\u2013256","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"2890_CR20","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1212\/01.wnl.0000218305.09183.70","volume":"66","author":"JM Castelo","year":"2006","unstructured":"Castelo JM et al (2006) Altered hippocampal-prefrontal activation in HIV patients during episodic memory encoding. Neurology 66(11):1688\u20131695","journal-title":"Neurology"},{"key":"2890_CR21","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1128\/mBio.00591-19","volume":"10","author":"J Kelschenbach","year":"2019","unstructured":"Kelschenbach J et al (2019) Efficient expression of HIV in immunocompetent mouse brain reveals a novel nonneurotoxic viral function in hippocampal synaptodendritic injury and memory impairment. mBio 10:4","journal-title":"mBio"},{"issue":"4","key":"2890_CR22","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1177\/0271678X19848510","volume":"40","author":"AC Johnson","year":"2020","unstructured":"Johnson AC, Miller JE, Cipolla MJ (2020) Memory impairment in spontaneously hypertensive rats is associated with hippocampal hypoperfusion and hippocampal vascular dysfunction. J Cereb Blood Flow Metab 40(4):845\u2013859","journal-title":"J Cereb Blood Flow Metab"},{"key":"2890_CR23","first-page":"11","volume":"9","author":"J Hokello","year":"2021","unstructured":"Hokello J et al (2021) Human immunodeficiency virus type-1 (HIV-1) transcriptional regulation, latency and therapy in the central nervous system. Vaccines (Basel) 9:11","journal-title":"Vaccines (Basel)"},{"issue":"2","key":"2890_CR24","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1006\/jmbi.1999.3060","volume":"293","author":"J Karn","year":"1999","unstructured":"Karn J (1999) Tackling Tat. J Mol Biol 293(2):235\u2013254","journal-title":"J Mol Biol"},{"issue":"23","key":"2890_CR25","doi-asserted-by":"publisher","first-page":"13519","DOI":"10.1073\/pnas.95.23.13519","volume":"95","author":"G Marzio","year":"1998","unstructured":"Marzio G et al (1998) HIV-1 tat transactivator recruits p300 and CREB-binding protein histone acetyltransferases to the viral promoter. Proc Natl Acad Sci U S A 95(23):13519\u201313524","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2890_CR26","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.molcel.2006.06.014","volume":"23","author":"BMDH Peterlin","year":"2006","unstructured":"Peterlin BMDH (2006) Price, Controlling the elongation phase of transcription with P-TEFb. Mol Cell 23(3):297\u2013305","journal-title":"Mol Cell"},{"issue":"4","key":"2890_CR27","doi-asserted-by":"publisher","first-page":"395","DOI":"10.2174\/1570162033485159","volume":"1","author":"ACH Rice","year":"2003","unstructured":"Rice ACH (2003) Herrmann, Regulation of TAK\/P-TEFb in CD4+ T lymphocytes and macrophages. Curr HIV Res 1(4):395\u2013404","journal-title":"Curr HIV Res"},{"issue":"1","key":"2890_CR28","doi-asserted-by":"publisher","first-page":"81","DOI":"10.2174\/187152612798994939","volume":"12","author":"S Mediouni","year":"2012","unstructured":"Mediouni S et al (2012) Antiretroviral therapy does not block the secretion of the human immunodeficiency virus tat protein. Infect Disord Drug Targets 12(1):81\u201386","journal-title":"Infect Disord Drug Targets"},{"issue":"6","key":"2890_CR29","doi-asserted-by":"publisher","first-page":"2205","DOI":"10.1182\/blood-2003-08-2928","volume":"103","author":"A Poggi","year":"2004","unstructured":"Poggi A et al (2004) Migration of V delta 1 and V delta 2 T cells in response to CXCR3 and CXCR4 ligands in healthy donors and HIV-1-infected patients: competition by HIV-1 Tat. Blood 103(6):2205\u20132213","journal-title":"Blood"},{"issue":"2","key":"2890_CR30","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1046\/j.0014-2956.2001.02671.x","volume":"269","author":"M Silhol","year":"2002","unstructured":"Silhol M et al (2002) Different mechanisms for cellular internalization of the HIV-1 Tat-derived cell penetrating peptide and recombinant proteins fused to Tat. Eur J Biochem 269(2):494\u2013501","journal-title":"Eur J Biochem"},{"issue":"5","key":"2890_CR31","doi-asserted-by":"publisher","first-page":"3254","DOI":"10.1074\/jbc.M006701200","volume":"276","author":"M Tyagi","year":"2001","unstructured":"Tyagi M et al (2001) Internalization of HIV-1 tat requires cell surface heparan sulfate proteoglycans. J Biol Chem 276(5):3254\u20133261","journal-title":"J Biol Chem"},{"issue":"17","key":"2890_CR32","doi-asserted-by":"publisher","first-page":"7941","DOI":"10.1073\/pnas.90.17.7941","volume":"90","author":"G Barillari","year":"1993","unstructured":"Barillari G et al (1993) The Tat protein of human immunodeficiency virus type 1, a growth factor for AIDS Kaposi sarcoma and cytokine-activated vascular cells, induces adhesion of the same cell types by using integrin receptors recognizing the RGD amino acid sequence. Proc Natl Acad Sci U S A 90(17):7941\u20137945","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2890_CR33","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1093\/brain\/awy339","volume":"142","author":"L Bertrand","year":"2019","unstructured":"Bertrand L, Cho HJ, Toborek M (2019) Blood-brain barrier pericytes as a target for HIV-1 infection. Brain 142(3):502\u2013511","journal-title":"Brain"},{"key":"2890_CR34","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2016.12.073","volume":"640","author":"CR Leibrand","year":"2017","unstructured":"Leibrand CR et al (2017) HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice. Neurosci Lett 640:136\u2013143","journal-title":"Neurosci Lett"},{"issue":"12","key":"2890_CR35","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/nm1296-1371","volume":"2","author":"A Albini","year":"1996","unstructured":"Albini A et al (1996) The angiogenesis induced by HIV-1 tat protein is mediated by the Flk-1\/KDR receptor on vascular endothelial cells. Nat Med 2(12):1371\u20131375","journal-title":"Nat Med"},{"issue":"1","key":"2890_CR36","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s12308-008-0002-z","volume":"1","author":"J Nyagol","year":"2008","unstructured":"Nyagol J et al (2008) HIV-1 Tat mimetic of VEGF correlates with increased microvessels density in AIDS-related diffuse large B-cell and Burkitt lymphomas. J Hematop 1(1):3\u201310","journal-title":"J Hematop"},{"issue":"3","key":"2890_CR37","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1023\/A:1023892223074","volume":"5","author":"MM Rusnati","year":"2002","unstructured":"Rusnati MM (2002) Presta, HIV-1 Tat protein and endothelium: from protein\/cell interaction to AIDS-associated pathologies. Angiogenesis 5(3):141\u2013151","journal-title":"Angiogenesis"},{"issue":"4","key":"2890_CR38","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1006\/nbdi.2000.0302","volume":"7","author":"M Sanchez-Alavez","year":"2000","unstructured":"Sanchez-Alavez M et al (2000) HIV- and FIV-derived gp120 alter spatial memory, LTP, and sleep in rats. Neurobiol Dis 7(4):384\u2013394","journal-title":"Neurobiol Dis"},{"issue":"1\u20132","key":"2890_CR39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.lfs.2009.03.013","volume":"85","author":"H Tang","year":"2009","unstructured":"Tang H et al (2009) Curcumin improves spatial memory impairment induced by human immunodeficiency virus type 1 glycoprotein 120 V3 loop peptide in rats. Life Sci 85(1\u20132):1\u201310","journal-title":"Life Sci"},{"issue":"1","key":"2890_CR40","doi-asserted-by":"publisher","first-page":"45","DOI":"10.4062\/biomolther.2019.119","volume":"28","author":"S Kim","year":"2020","unstructured":"Kim S, Lee M, Choi YK (2020) The role of a neurovascular signaling pathway involving hypoxia-inducible factor and notch in the function of the central nervous system. Biomol Ther (Seoul) 28(1):45\u201357","journal-title":"Biomol Ther (Seoul)"},{"key":"2890_CR41","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3389\/fcell.2018.00169","volume":"6","author":"LY Wu","year":"2018","unstructured":"Wu LY, He YL, Zhu LL (2018) Possible role of PHD inhibitors as hypoxia-mimicking agents in the maintenance of neural stem cells\u2019 self-renewal properties. Front Cell Dev Biol 6:169","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"2890_CR42","first-page":"1","volume":"51","author":"EJ Yeo","year":"2019","unstructured":"Yeo EJ (2019) Hypoxia and aging. Exp Mol Med 51(6):1\u201315","journal-title":"Exp Mol Med"},{"issue":"5\u20136","key":"2890_CR43","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1016\/S0006-2952(02)01155-3","volume":"64","author":"JP Piret","year":"2002","unstructured":"Piret JP et al (2002) Is HIF-1alpha a pro- or an anti-apoptotic protein? Biochem Pharmacol 64(5\u20136):889\u2013892","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"2890_CR44","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1111\/bjd.12592","volume":"170","author":"Y Ji","year":"2014","unstructured":"Ji Y et al (2014) Upregulated autocrine vascular endothelial growth factor (VEGF)\/VEGF receptor-2 loop prevents apoptosis in haemangioma-derived endothelial cells. Br J Dermatol 170(1):78\u201386","journal-title":"Br J Dermatol"},{"issue":"1\u20132","key":"2890_CR45","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/s10555-011-9337-5","volume":"31","author":"S Masoumi Moghaddam","year":"2012","unstructured":"Masoumi Moghaddam S et al (2012) Significance of vascular endothelial growth factor in growth and peritoneal dissemination of ovarian cancer. Cancer Metastasis Rev 31(1\u20132):143\u2013162","journal-title":"Cancer Metastasis Rev"},{"issue":"7","key":"2890_CR46","first-page":"1990","volume":"10","author":"Y Nicolau","year":"2018","unstructured":"Nicolau Y et al (2018) SiRNA silencing of VEGF, IGFs, and their receptors in human retinal microvascular endothelial cells. Am J Transl Res 10(7):1990\u20132003","journal-title":"Am J Transl Res"},{"issue":"Pt 2","key":"2890_CR47","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1242\/jcs.111.2.183","volume":"111","author":"DJD Antic","year":"1998","unstructured":"Antic DJD (1998) Keene, Messenger ribonucleoprotein complexes containing human ELAV proteins: interactions with cytoskeleton and translational apparatus. J Cell Sci 111(Pt 2):183\u2013197","journal-title":"J Cell Sci"},{"issue":"34","key":"2890_CR48","doi-asserted-by":"publisher","first-page":"12065","DOI":"10.1073\/pnas.0504702102","volume":"102","author":"A Pascale","year":"2005","unstructured":"Pascale A et al (2005) Neuronal ELAV proteins enhance mRNA stability by a PKCalpha-dependent pathway. Proc Natl Acad Sci U S A 102(34):12065\u201312070","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"20","key":"2890_CR49","doi-asserted-by":"publisher","first-page":"11668","DOI":"10.1073\/pnas.191388398","volume":"98","author":"A Quattrone","year":"2001","unstructured":"Quattrone A et al (2001) Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins. Proc Natl Acad Sci U S A 98(20):11668\u201311673","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"2890_CR50","doi-asserted-by":"publisher","first-page":"7997","DOI":"10.1093\/nar\/gkt539","volume":"41","author":"T Arcondeguy","year":"2013","unstructured":"Arcondeguy T et al (2013) VEGF-A mRNA processing, stability and translation: a paradigm for intricate regulation of gene expression at the post-transcriptional level. Nucleic Acids Res 41(17):7997\u20138010","journal-title":"Nucleic Acids Res"},{"issue":"18","key":"2890_CR51","doi-asserted-by":"publisher","first-page":"3366","DOI":"10.1091\/mbc.e10-07-0617","volume":"22","author":"S Chamboredon","year":"2011","unstructured":"Chamboredon S et al (2011) Hypoxia-inducible factor-1alpha mRNA: a new target for destabilization by tristetraprolin in endothelial cells. Mol Biol Cell 22(18):3366\u20133378","journal-title":"Mol Biol Cell"},{"issue":"10","key":"2890_CR52","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1038\/onc.2011.325","volume":"31","author":"L Chaudhuri","year":"2012","unstructured":"Chaudhuri L et al (2012) Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene 31(10):1207\u20131216","journal-title":"Oncogene"},{"issue":"7","key":"2890_CR53","doi-asserted-by":"publisher","first-page":"E20","DOI":"10.1093\/nar\/28.7.e20","volume":"28","author":"PH King","year":"2000","unstructured":"King PH (2000) RNA-binding analyses of HuC and HuD with the VEGF and c-myc 3\u2032-untranslated regions using a novel ELISA-based assay. Nucleic Acids Res 28(7):E20","journal-title":"Nucleic Acids Res"},{"key":"2890_CR54","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fimmu.2011.00045","volume":"2","author":"MA Rahat","year":"2011","unstructured":"Rahat MA, Bitterman H, Lahat N (2011) Molecular mechanisms regulating macrophage response to hypoxia. Front Immunol 2:45","journal-title":"Front Immunol"},{"issue":"17","key":"2890_CR55","doi-asserted-by":"publisher","first-page":"5889","DOI":"10.1128\/MCB.21.17.5889-5898.2001","volume":"21","author":"W Wang","year":"2001","unstructured":"Wang W et al (2001) Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol 21(17):5889\u20135898","journal-title":"Mol Cell Biol"},{"key":"2890_CR56","doi-asserted-by":"publisher","first-page":"298","DOI":"10.3389\/fnagi.2016.00298","volume":"8","author":"A O\u2019Shea","year":"2016","unstructured":"O\u2019Shea A et al (2016) Cognitive aging and the hippocampus in older adults. Front Aging Neurosci 8:298","journal-title":"Front Aging Neurosci"},{"key":"2890_CR57","doi-asserted-by":"publisher","first-page":"101616","DOI":"10.1016\/j.pneurobio.2019.101616","volume":"181","author":"B Cotto","year":"2019","unstructured":"Cotto B, Natarajanseenivasan K, Langford D (2019) HIV-1 infection alters energy metabolism in the brain: contributions to HIV-associated neurocognitive disorders. Prog Neurobiol 181:101616","journal-title":"Prog Neurobiol"},{"issue":"1","key":"2890_CR58","doi-asserted-by":"publisher","first-page":"e1143544","DOI":"10.1080\/21688370.2016.1143544","volume":"4","author":"I Wilhelm","year":"2016","unstructured":"Wilhelm I et al (2016) Heterogeneity of the blood-brain barrier. Tissue Barriers 4(1):e1143544","journal-title":"Tissue Barriers"},{"issue":"32","key":"2890_CR59","doi-asserted-by":"publisher","first-page":"16462","DOI":"10.1074\/jbc.M116.730440","volume":"291","author":"A Sen","year":"2016","unstructured":"Sen A et al (2016) Protein kinase C (PKC) promotes synaptogenesis through membrane accumulation of the postsynaptic density protein PSD-95. J Biol Chem 291(32):16462\u201316476","journal-title":"J Biol Chem"},{"issue":"8","key":"2890_CR60","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1016\/j.freeradbiomed.2010.01.028","volume":"48","author":"JB Zielonka","year":"2010","unstructured":"Zielonka JB (2010) Kalyanaraman, Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med 48(8):983\u20131001","journal-title":"Free Radic Biol Med"},{"issue":"19","key":"2890_CR61","doi-asserted-by":"publisher","first-page":"7538","DOI":"10.1523\/JNEUROSCI.0260-15.2015","volume":"35","author":"A Sen","year":"2015","unstructured":"Sen A, Nelson TJ, Alkon DL (2015) ApoE4 and A\u03b2 oligomers reduce BDNF expression via HDAC nuclear translocation. J Neurosci 35(19):7538\u201351","journal-title":"J Neurosci"},{"issue":"20","key":"2890_CR62","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1001\/jama.2013.281053","volume":"310","author":"A.","year":"2013","unstructured":"World Medical, A. (2013) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA 310(20):2191\u20132194","journal-title":"JAMA"},{"issue":"3","key":"2890_CR63","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1383-5742(97)00035-5","volume":"387","author":"H Kasai","year":"1997","unstructured":"Kasai H (1997) Analysis of a form of oxidative DNA damage, 8-hydroxy-2\u2032-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res 387(3):147\u2013163","journal-title":"Mutat Res"},{"issue":"11","key":"2890_CR64","doi-asserted-by":"publisher","first-page":"330","DOI":"10.15698\/cst2019.11.203","volume":"3","author":"M Zille","year":"2019","unstructured":"Zille M et al (2019) The impact of endothelial cell death in the brain and its role after stroke: A systematic review. Cell Stress 3(11):330\u2013347","journal-title":"Cell Stress"},{"issue":"1","key":"2890_CR65","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s10020-018-0026-5","volume":"24","author":"L Heikal","year":"2018","unstructured":"Heikal L et al (2018) Assessment of HIF-1alpha expression and release following endothelial injury in-vitro and in-vivo. Mol Med 24(1):22","journal-title":"Mol Med"},{"issue":"10","key":"2890_CR66","doi-asserted-by":"publisher","first-page":"2003","DOI":"10.1016\/j.cellsig.2007.05.013","volume":"19","author":"K Holmes","year":"2007","unstructured":"Holmes K et al (2007) Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition. Cell Signal 19(10):2003\u20132012","journal-title":"Cell Signal"},{"key":"2890_CR67","first-page":"374963","volume":"2013","author":"Y Zhou","year":"2013","unstructured":"Zhou Y et al (2013) Reactive oxygen species in vascular formation and development. Oxid Med Cell Longev 2013:374963","journal-title":"Oxid Med Cell Longev"},{"issue":"8","key":"2890_CR68","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.4161\/cc.8.8.8147","volume":"8","author":"YY Mebratu","year":"2009","unstructured":"Mebratu YY (2009) Tesfaigzi, How ERK1\/2 activation controls cell proliferation and cell death: is subcellular localization the answer? Cell Cycle 8(8):1168\u20131175","journal-title":"Cell Cycle"},{"key":"2890_CR69","first-page":"2153","volume":"18","author":"M Amadio","year":"2012","unstructured":"Amadio M et al (2012) Protein kinase C activation affects, via the mRNA-binding Hu-antigen R\/ELAV protein, vascular endothelial growth factor expression in a pericytic\/endothelial coculture model. Mol Vis 18:2153\u20132164","journal-title":"Mol Vis"},{"issue":"5","key":"2890_CR70","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1161\/ATVBAHA.108.162842","volume":"28","author":"C Rask-Madsen","year":"2008","unstructured":"Rask-Madsen C, King GL (2008) Differential regulation of VEGF signaling by PKC-alpha and PKC-epsilon in endothelial cells. Arterioscler Thromb Vasc Biol 28(5):919\u2013924","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"47","key":"2890_CR71","doi-asserted-by":"publisher","first-page":"49064","DOI":"10.1074\/jbc.M407715200","volume":"279","author":"FL Muller","year":"2004","unstructured":"Muller FL, Liu Y, VanRemmen H (2004) Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 279(47):49064\u201373","journal-title":"J Biol Chem"},{"issue":"7","key":"2890_CR72","doi-asserted-by":"publisher","first-page":"7694","DOI":"10.1364\/OE.20.007694","volume":"20","author":"G Liu","year":"2012","unstructured":"Liu G et al (2012) High-resolution imaging of microvasculature in human skin in-vivo with optical coherence tomography. Opt Express 20(7):7694\u20137705","journal-title":"Opt Express"},{"issue":"1","key":"2890_CR73","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1186\/s13041-016-0237-z","volume":"9","author":"MS Lillenes","year":"2016","unstructured":"Lillenes MS et al (2016) Altered DNA base excision repair profile in brain tissue and blood in Alzheimer\u2019s disease. Mol Brain 9(1):61","journal-title":"Mol Brain"},{"issue":"18","key":"2890_CR74","doi-asserted-by":"publisher","first-page":"2444","DOI":"10.1089\/ars.2012.5039","volume":"18","author":"RX Santos","year":"2013","unstructured":"Santos RX et al (2013) Mitochondrial DNA oxidative damage and repair in aging and Alzheimer\u2019s disease. Antioxid Redox Signal 18(18):2444\u20132457","journal-title":"Antioxid Redox Signal"},{"key":"2890_CR75","doi-asserted-by":"publisher","first-page":"406960","DOI":"10.1155\/2014\/406960","volume":"2014","author":"QN Dinh","year":"2014","unstructured":"Dinh QN et al (2014) Roles of inflammation, oxidative stress, and vascular dysfunction in hypertension. Biomed Res Int 2014:406960","journal-title":"Biomed Res Int"},{"issue":"3","key":"2890_CR76","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s11481-007-9073-3","volume":"2","author":"YGY Fan","year":"2007","unstructured":"Fan YGY (2007) Yang, Therapeutic angiogenesis for brain ischemia: a brief review. J Neuroimmune Pharmacol 2(3):284\u2013289","journal-title":"J Neuroimmune Pharmacol"},{"key":"2890_CR77","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1007\/978-3-211-09469-3_36","volume":"105","author":"H Su","year":"2008","unstructured":"Su H et al (2008) Development of a cerebral microvascular dysplasia model in rodents. Acta Neurochir Suppl 105:185\u2013189","journal-title":"Acta Neurochir Suppl"},{"issue":"5","key":"2890_CR78","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1007\/s00702-009-0226-9","volume":"116","author":"BS Desai","year":"2009","unstructured":"Desai BS et al (2009) Evidence of angiogenic vessels in Alzheimer\u2019s disease. J Neural Transm (Vienna) 116(5):587\u2013597","journal-title":"J Neural Transm (Vienna)"},{"issue":"3","key":"2890_CR79","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s004010051083","volume":"98","author":"T Kemper","year":"1999","unstructured":"Kemper T et al (1999) Microinfarction as a result of hypertension in a primate model of cerebrovascular disease. Acta Neuropathol 98(3):295\u2013303","journal-title":"Acta Neuropathol"},{"issue":"2","key":"2890_CR80","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/S1568-1637(02)00064-8","volume":"2","author":"DR Riddle","year":"2003","unstructured":"Riddle DR, Sonntag WE, Lichtenwalner RJ (2003) Microvascular plasticity in aging. Ageing Res Rev 2(2):149\u201368","journal-title":"Ageing Res Rev"},{"issue":"2","key":"2890_CR81","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.pharmthera.2011.10.004","volume":"133","author":"N Toda","year":"2012","unstructured":"Toda N (2012) Age-related changes in endothelial function and blood flow regulation. Pharmacol Ther 133(2):159\u2013176","journal-title":"Pharmacol Ther"},{"issue":"9","key":"2890_CR82","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/s41569-018-0030-z","volume":"15","author":"Z Ungvari","year":"2018","unstructured":"Ungvari Z et al (2018) Endothelial dysfunction and angiogenesis impairment in the ageing vasculature. Nat Rev Cardiol 15(9):555\u2013565","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"2890_CR83","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1089\/ars.2009.2940","volume":"13","author":"Z Lu","year":"2010","unstructured":"Lu Z et al (2010) PGC-1 alpha regulates expression of myocardial mitochondrial antioxidants and myocardial oxidative stress after chronic systolic overload. Antioxid Redox Signal 13(7):1011\u20131022","journal-title":"Antioxid Redox Signal"},{"issue":"19","key":"2890_CR84","doi-asserted-by":"publisher","first-page":"2530","DOI":"10.1101\/gad.1024602","volume":"16","author":"TA Baudino","year":"2002","unstructured":"Baudino TA et al (2002) c-Myc is essential for vasculogenesis and angiogenesis during development and tumor progression. Genes Dev 16(19):2530\u20132543","journal-title":"Genes Dev"},{"issue":"9","key":"2890_CR85","doi-asserted-by":"publisher","first-page":"e73146","DOI":"10.1371\/journal.pone.0073146","volume":"8","author":"V Florea","year":"2013","unstructured":"Florea V et al (2013) c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype. PLoS ONE 8(9):e73146","journal-title":"PLoS ONE"},{"key":"2890_CR86","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.nbd.2013.03.012","volume":"55","author":"J Hongpaisan","year":"2013","unstructured":"Hongpaisan J et al (2013) PKC activation during training restores mushroom spine synapses and memory in the aged rat. Neurobiol Dis 55:44\u201362","journal-title":"Neurobiol Dis"},{"key":"2890_CR87","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fgene.2019.00332","volume":"10","author":"H Otsuka","year":"2019","unstructured":"Otsuka H et al (2019) Emerging evidence of translational control by AU-rich element-binding proteins. Front Genet 10:332","journal-title":"Front Genet"},{"issue":"3","key":"2890_CR88","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.3233\/JAD-171008","volume":"63","author":"A Sen","year":"2018","unstructured":"Sen A et al (2018) Loss in PKC epsilon causes downregulation of MnSOD and BDNF expression in neurons of Alzheimer\u2019s disease hippocampus. J Alzheimers Dis 63(3):1173\u20131189","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"2890_CR89","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/s00709-013-0515-x","volume":"251","author":"J Bereiter-Hahn","year":"2014","unstructured":"Bereiter-Hahn J (2014) Do we age because we have mitochondria? Protoplasma 251(1):3\u201323","journal-title":"Protoplasma"},{"key":"2890_CR90","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1007\/978-94-007-2869-1_14","volume":"942","author":"HCYH Lee","year":"2012","unstructured":"Lee HCYH (2012) Wei, Mitochondria and aging. Adv Exp Med Biol 942:311\u2013327","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"2890_CR91","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12035-014-8991-3","volume":"53","author":"R Ma","year":"2016","unstructured":"Ma R et al (2016) HIV Tat-mediated induction of human brain microvascular endothelial cell apoptosis involves endoplasmic reticulum stress and mitochondrial dysfunction. Mol Neurobiol 53(1):132\u2013142","journal-title":"Mol Neurobiol"},{"key":"2890_CR92","first-page":"8","volume":"18","author":"DY Tian","year":"2017","unstructured":"Tian DY et al (2017) Notch signaling in endothelial cells: is it the therapeutic target for vascular neointimal hyperplasia? Int J Mol Sci 18:8","journal-title":"Int J Mol Sci"},{"issue":"12","key":"2890_CR93","doi-asserted-by":"publisher","first-page":"23059","DOI":"10.3390\/ijms151223059","volume":"15","author":"M Zhu","year":"2014","unstructured":"Zhu M et al (2014) L-cystathionine inhibits the mitochondria-mediated macrophage apoptosis induced by oxidized low density lipoprotein. Int J Mol Sci 15(12):23059\u201323073","journal-title":"Int J Mol Sci"},{"issue":"9","key":"2890_CR94","doi-asserted-by":"publisher","first-page":"4604","DOI":"10.1128\/MCB.16.9.4604","volume":"16","author":"JA Forsythe","year":"1996","unstructured":"Forsythe JA et al (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol Cell Biol 16(9):4604\u20134613","journal-title":"Mol Cell Biol"},{"issue":"11","key":"2890_CR95","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1093\/cid\/cix1075","volume":"66","author":"A Moulignier","year":"2018","unstructured":"Moulignier A et al (2018) Silent cerebral small-vessel disease is twice as prevalent in middle-aged individuals with well-controlled, combination antiretroviral therapy-treated human immunodeficiency virus (HIV) than in HIV-uninfected individuals. Clin Infect Dis 66(11):1762\u20131769","journal-title":"Clin Infect Dis"},{"issue":"6","key":"2890_CR96","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1097\/QAD.0000000000001414","volume":"31","author":"T Su","year":"2017","unstructured":"Su T et al (2017) Cerebral blood flow and cognitive function in HIV-infected men with sustained suppressed viremia on combination antiretroviral therapy. AIDS 31(6):847\u2013856","journal-title":"AIDS"},{"key":"2890_CR97","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1007\/978-981-13-3681-2_17","volume":"91","author":"RNY Kalaria","year":"2019","unstructured":"Kalaria RNY (2019) Hase, Neurovascular ageing and age-related diseases. Subcell Biochem 91:477\u2013499","journal-title":"Subcell Biochem"},{"issue":"3","key":"2890_CR98","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0304-3940(02)00814-5","volume":"330","author":"C Cioni","year":"2002","unstructured":"Cioni C (2002) Annunziata, Circulating gp120 alters the blood-brain barrier permeability in HIV-1 gp120 transgenic mice. Neurosci Lett 330(3):299\u2013301","journal-title":"Neurosci Lett"},{"key":"2890_CR99","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.mito.2015.10.001","volume":"25","author":"AAM Picca","year":"2015","unstructured":"Picca AAM (2015) Lezza, Regulation of mitochondrial biogenesis through TFAM-mitochondrial DNA interactions: useful insights from aging and calorie restriction studies. Mitochondrion 25:67\u201375","journal-title":"Mitochondrion"},{"issue":"2","key":"2890_CR100","doi-asserted-by":"publisher","first-page":"1748983","DOI":"10.1080\/21688370.2020.1748983","volume":"8","author":"K Liao","year":"2020","unstructured":"Liao K et al (2020) HIV Tat-mediated induction of autophagy regulates the disruption of ZO-1 in brain endothelial cells. Tissue Barriers 8(2):1748983","journal-title":"Tissue Barriers"},{"key":"2890_CR101","doi-asserted-by":"publisher","first-page":"482575","DOI":"10.1100\/2012\/482575","volume":"2012","author":"J Louboutin","year":"2012","unstructured":"Louboutin J, Strayer DS (2012) Blood-brain barrier abnormalities caused by HIV-1 gp120: mechanistic and therapeutic implications. ScientificWorldJournal 2012:482575","journal-title":"ScientificWorldJournal"},{"issue":"1","key":"2890_CR102","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/S1044-7431(03)00171-4","volume":"24","author":"H Pu","year":"2003","unstructured":"Pu H et al (2003) HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain. Mol Cell Neurosci 24(1):224\u2013237","journal-title":"Mol Cell Neurosci"},{"key":"2890_CR103","doi-asserted-by":"publisher","first-page":"102146","DOI":"10.1016\/j.nicl.2019.102146","volume":"25","author":"S Dolui","year":"2020","unstructured":"Dolui S et al (2020) Arterial spin labeling versus (18)F-FDG-PET to identify mild cognitive impairment. Neuroimage Clin 25:102146","journal-title":"Neuroimage Clin"},{"issue":"2","key":"2890_CR104","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1111\/jon.12264","volume":"26","author":"S Verclytte","year":"2016","unstructured":"Verclytte S et al (2016) Cerebral hypoperfusion and hypometabolism detected by arterial spin labeling MRI and FDG-PET in early-onset Alzheimer\u2019s disease. J Neuroimaging 26(2):207\u2013212","journal-title":"J Neuroimaging"},{"issue":"12","key":"2890_CR105","doi-asserted-by":"publisher","first-page":"2211","DOI":"10.3174\/ajnr.A5902","volume":"39","author":"J Narvid","year":"2018","unstructured":"Narvid J et al (2018) Abnormal cerebral perfusion profile in older adults with HIV-associated neurocognitive disorder: discriminative power of arterial spin-labeling. AJNR Am J Neuroradiol 39(12):2211\u20132217","journal-title":"AJNR Am J Neuroradiol"},{"issue":"1","key":"2890_CR106","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1111\/bpa.12365","volume":"27","author":"Z Arvanitakis","year":"2017","unstructured":"Arvanitakis Z et al (2017) The relationship of cerebral vessel pathology to brain microinfarcts. Brain Pathol 27(1):77\u201385","journal-title":"Brain Pathol"},{"issue":"5","key":"2890_CR107","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1007\/s00401-016-1571-z","volume":"131","author":"RN Kalaria","year":"2016","unstructured":"Kalaria RN (2016) Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer\u2019s disease. Acta Neuropathol 131(5):659\u2013685","journal-title":"Acta Neuropathol"},{"issue":"9","key":"2890_CR108","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.1161\/STROKEAHA.112.655803","volume":"43","author":"RN Kalaria","year":"2012","unstructured":"Kalaria RN (2012) Cerebrovascular disease and mechanisms of cognitive impairment: evidence from clinicopathological studies in humans. Stroke 43(9):2526\u20132534","journal-title":"Stroke"},{"issue":"2","key":"2890_CR109","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1503\/jpn.180002","volume":"44","author":"X Wang","year":"2019","unstructured":"Wang X et al (2019) Brain grey-matter volume alteration in adult patients with bipolar disorder under different conditions: a voxel-based meta-analysis. J Psychiatry Neurosci 44(2):89\u2013101","journal-title":"J Psychiatry Neurosci"},{"issue":"5","key":"2890_CR110","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.bbadis.2015.12.010","volume":"1862","author":"G Banerjee","year":"2016","unstructured":"Banerjee G et al (2016) Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment. Biochim Biophys Acta 1862(5):926\u2013938","journal-title":"Biochim Biophys Acta"},{"issue":"Suppl 3","key":"2890_CR111","doi-asserted-by":"publisher","first-page":"S115","DOI":"10.1097\/00002093-199912003-00017","volume":"13","author":"RNC Kalaria","year":"1999","unstructured":"Kalaria RNC (1999) Ballard, Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Dis Assoc Disord 13(Suppl 3):S115\u2013S123","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"5","key":"2890_CR112","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1111\/nan.12003","volume":"39","author":"E Kovari","year":"2013","unstructured":"Kovari E et al (2013) The relationship between cerebral amyloid angiopathy and cortical microinfarcts in brain ageing and Alzheimer\u2019s disease. Neuropathol Appl Neurobiol 39(5):498\u2013509","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"11","key":"2890_CR113","doi-asserted-by":"publisher","first-page":"2146","DOI":"10.1111\/j.1532-5415.2009.02521.x","volume":"57","author":"JA Schneider","year":"2009","unstructured":"Schneider JA (2009) High blood pressure and microinfarcts: a link between vascular risk factors, dementia, and clinical Alzheimer\u2019s disease. J Am Geriatr Soc 57(11):2146\u20132147","journal-title":"J Am Geriatr Soc"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02890-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-02890-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02890-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T12:40:05Z","timestamp":1660048805000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-02890-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,4]]},"references-count":113,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["2890"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-02890-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,4]]},"assertion":[{"value":"9 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 May 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 June 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present work was carried out in accordance with the Code of Ethics of the World Medical Association (Declaration of Helsinki) for experiments involving humans. All patients (or relatives\/representatives who had the power of attorney) signed informed consent forms.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Statement\/Informed Consent"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent of Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest."}}]}}