{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T03:53:13Z","timestamp":1773201193794,"version":"3.50.1"},"reference-count":102,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1007\/s12035-022-02933-0","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T11:02:54Z","timestamp":1657278174000},"page":"5835-5855","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Influence of Gestational Chlorpyrifos Exposure on ASD-like Behaviors in an fmr1-KO Rat Model"],"prefix":"10.1007","volume":"59","author":[{"given":"Cristian","family":"Perez-Fernandez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Matamala Montoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Morales-Navas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laia","family":"Guardia-Escote","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Cabr\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Teresa","family":"Colomina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Estela","family":"Gim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2190-2006","authenticated-orcid":false,"given":"Fernando","family":"S\u00e1nchez-Santed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,8]]},"reference":[{"issue":"10146","key":"2933_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/S0140-6736(18)31129-2","volume":"392","author":"C Lord","year":"2018","unstructured":"Lord C, Elsabbagh M, Baird G, Veenstra-Vanderweele J (2018) Autism spectrum disorder. Lancet 392(10146):508\u2013520. https:\/\/doi.org\/10.1016\/S0140-6736(18)31129-2","journal-title":"Lancet"},{"issue":"6","key":"2933_CR2","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.1007\/s10803-006-0259-y","volume":"37","author":"SE Christ","year":"2007","unstructured":"Christ SE, Holt DD, White DA, Green L (2007) Inhibitory control in children with autism spectrum disorder. J Autism Dev Disord 37(6):1155\u20131165. https:\/\/doi.org\/10.1007\/s10803-006-0259-y","journal-title":"J Autism Dev Disord"},{"key":"2933_CR3","doi-asserted-by":"publisher","unstructured":"Whyatt C, Craig C (2013) Sensory-motor problems in autism. Front Integr Neurosci 7 https:\/\/doi.org\/10.3389\/fnint201300051","DOI":"10.3389\/fnint201300051"},{"issue":"2","key":"2933_CR4","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1097\/YCO0000000000000133","volume":"28","author":"RA Vasa","year":"2015","unstructured":"Vasa RA, Mazurek MO (2015) An update on anxiety in youth with autism spectrum disorders. Curr Opin Psychiatry 28(2):83\u201390. https:\/\/doi.org\/10.1097\/YCO0000000000000133","journal-title":"Curr Opin Psychiatry"},{"key":"2933_CR5","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/J.NEUBIOREV.2021.06.028","volume":"128","author":"L Choi","year":"2021","unstructured":"Choi L, An JY (2021) Genetic architecture of autism spectrum disorder: lessons from large-scale genomic studies. Neurosci Biobehav Rev 128:244\u2013257. https:\/\/doi.org\/10.1016\/J.NEUBIOREV.2021.06.028","journal-title":"Neurosci Biobehav Rev"},{"key":"2933_CR6","doi-asserted-by":"crossref","unstructured":"Chaste P, Leboyer M (2012) Autism risk factors: genes environment and gene-environment interactions. Dialogues Clin Neurosci 2012,14(3) 281. https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3513682\/","DOI":"10.31887\/DCNS.2012.14.3\/pchaste"},{"key":"2933_CR7","doi-asserted-by":"crossref","unstructured":"Karimi P, Kamali E, Mousavi SM, Karahmadi M (2017) Environmental factors influencing the risk of autism In. J Res Med Sci\u00a022(1) Isfahan University of Medical Sciences (IUMS) https:\/\/doi.org\/10.4103\/1735\u20131995200272","DOI":"10.4103\/1735-1995.200272"},{"key":"2933_CR8","doi-asserted-by":"publisher","unstructured":"Tessari L, Angriman M, D\u00edaz-Rom\u00e1n A, Zhang J, Conca A, Cortese S (2020) Association between exposure to pesticides and ADHD or autism spectrum disorder: a systematic review of the literature. J Atten Disord https:\/\/doi.org\/10.1177\/1087054720940402","DOI":"10.1177\/1087054720940402"},{"issue":"10","key":"2933_CR9","doi-asserted-by":"publisher","first-page":"5190","DOI":"10.3390\/IJERPH18105190","volume":"18","author":"J Biosca-Brull","year":"2021","unstructured":"Biosca-Brull J, P\u00e9rez-Fern\u00e1ndez C, Mora S, Carrillo B, Pinos H, Conejo NM, Collado P, Arias JL, Mart\u00edn-S\u00e1nchez F, S\u00e1nchez-Santed F, Colomina MT (2021) Relationship between autism spectrum disorder and pesticides: a systematic review of human and preclinical models. Int J Environ Res Public Health 18(10):5190. https:\/\/doi.org\/10.3390\/IJERPH18105190","journal-title":"Int J Environ Res Public Health"},{"issue":"17","key":"2933_CR10","doi-asserted-by":"publisher","first-page":"6376","DOI":"10.3390\/IJERPH17176376","volume":"17","author":"M Morales-Navas","year":"2020","unstructured":"Morales-Navas M, Casta\u00f1o-Casta\u00f1o S, P\u00e9rez-Fern\u00e1ndez C, S\u00e1nchez-Gil A, Colomina MT, Leinekugel X, S\u00e1nchez-Santed F (2020) Similarities between the effects of prenatal chlorpyrifos and valproic acid on ultrasonic vocalization in infant Wistar rats. Int J Environ Res Public Health 17(17):6376. https:\/\/doi.org\/10.3390\/IJERPH17176376","journal-title":"Int J Environ Res Public Health"},{"issue":"sup2","key":"2933_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/10408440802272158","volume":"38","author":"DL Eaton","year":"2008","unstructured":"Eaton DL, Daroff RB, Autrup H, Bridges J, Buffler P, Costa LG, Coyle J, McKhann G, Mobley WC, Nadel L, Neubert D, Schulte-Hermann R, Spencer PS (2008) Review of the toxicology of chlorpyrifos with an emphasis on human exposure and neurodevelopment. Crit Rev Toxicol 38(sup2):1\u2013125. https:\/\/doi.org\/10.1080\/10408440802272158","journal-title":"Crit Rev Toxicol"},{"issue":"1","key":"2933_CR12","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s12993-019-0153-3","volume":"15","author":"A Lan","year":"2019","unstructured":"Lan A, Stein D, Portillo M, Toiber D, Kofman O (2019) Impaired innate and conditioned social behavior in adult C57Bl6\/J mice prenatally exposed to chlorpyrifos. Behav Brain Funct 15(1):2. https:\/\/doi.org\/101186\/s12993-019-0153-3","journal-title":"Behav Brain Funct"},{"issue":"1","key":"2933_CR13","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s12940-017-0251-3","volume":"16","author":"A Lan","year":"2017","unstructured":"Lan A, Kalimian M, Amram B, Kofman O (2017) Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6\/J mice. Environ Health 16(1):43. https:\/\/doi.org\/10.1186\/s12940-017-0251-3","journal-title":"Environ Health"},{"issue":"4","key":"2933_CR14","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1021\/ACSCHEMBIO.1C00053","volume":"16","author":"AC Abreu","year":"2021","unstructured":"Abreu AC, Navas MM, Fern\u00e1ndez CP, S\u00e1nchez-Santed F, Fern\u00e1ndez I (2021) NMR-based metabolomics approach to explore brain metabolic changes induced by prenatal exposure to autism-inducing chemicals. ACS Chem Biol 16(4):753\u2013765. https:\/\/doi.org\/10.1021\/ACSCHEMBIO.1C00053","journal-title":"ACS Chem Biol"},{"issue":"3","key":"2933_CR15","doi-asserted-by":"publisher","first-page":"e0121663","DOI":"10.1371\/journal.pone.0121663","volume":"10","author":"A De Felice","year":"2015","unstructured":"De Felice A, Scattoni ML, Ricceri L, Calamandrei G (2015) Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism. PLoS One 10(3):e0121663. https:\/\/doi.org\/10.1371\/journal.pone.0121663","journal-title":"PLoS One"},{"issue":"1","key":"2933_CR16","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1186\/s12974-016-0617-4","volume":"13","author":"A De Felice","year":"2016","unstructured":"De Felice A, Anita G, Calamandrei G, Minghetti L (2016) Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism. J Neuroinflammation 13(1):149. https:\/\/doi.org\/10.1186\/s12974-016-0617-4","journal-title":"J Neuroinflammation"},{"key":"2933_CR17","doi-asserted-by":"publisher","first-page":"108684","DOI":"10.1016\/J.ENVRES.2019.108684","volume":"178","author":"P Basaure","year":"2019","unstructured":"Basaure P, Guardia-Escote L, Biosca-Brull J, Blanco J, Cabr\u00e9 M, Peris-Sampedro F, S\u00e1nchez-Santed F, Domingo JL, Colomina MT (2019) Exposure to chlorpyrifos at different ages triggers APOE genotype-specific responses in social behavior body weight and hypothalamic gene expression. Environ Res 178:108684. https:\/\/doi.org\/10.1016\/J.ENVRES.2019.108684","journal-title":"Environ Res"},{"issue":"1","key":"2933_CR18","doi-asserted-by":"publisher","first-page":"AN20120060","DOI":"10.1042\/AN20120060","volume":"5","author":"BR Mullen","year":"2013","unstructured":"Mullen BR, Khialeeva E, Hoffman DB, Ghiani CA, Carpenter EM (2013) Decreased reelin expression and organophosphate pesticide exposure alters mouse behaviour and brain morphology. ASN Neuro 5(1):AN20120060. https:\/\/doi.org\/10.1042\/AN20120060","journal-title":"ASN Neuro"},{"key":"2933_CR19","doi-asserted-by":"publisher","unstructured":"Fyke W, Velinov M (2021) FMR1 and autism an intriguing connection revisited. Genes 12(8). https:\/\/doi.org\/10.3390\/GENES12081218","DOI":"10.3390\/GENES12081218"},{"issue":"10","key":"2933_CR20","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1242\/dmm.026120","volume":"9","author":"B Ellenbroek","year":"2016","unstructured":"Ellenbroek B, Youn J (2016) Rodent models in neuroscience research: Is it a rat race? DMM Dis Models Mech 9(10):1079\u20131087. https:\/\/doi.org\/10.1242\/dmm.026120","journal-title":"DMM Dis Models Mech"},{"key":"2933_CR21","doi-asserted-by":"publisher","unstructured":"Siegel-Ramsay JE, LRomaniuk L, Whalley HC, Roberts N, Holly Branigan H, Stanfield AC, Lawrie SM, Dauvermann MR (2021) Glutamate and functional connectivity - support for the excitatory-inhibitory imbalance hypothesis in autism spectrum disorders. Psychiatry Res Neuroimaging 313 https:\/\/doi.org\/10.1016\/JPSCYCHRESNS2021111302","DOI":"10.1016\/JPSCYCHRESNS2021111302"},{"key":"2933_CR22","doi-asserted-by":"publisher","unstructured":"Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Garrido-C\u00e1rdenas JA, Colomina MT, Gim\u00e9nez E, S\u00e1nchez-Santed F (2020) Long-term effects of low doses of Chlorpyrifos exposure at the preweaning developmental stage: a locomotor pharmacological brain gene expression and gut microbiome analysis. Food Chem Toxicol 135 https:\/\/doi.org\/10.1016\/jfct2019110865","DOI":"10.1016\/jfct2019110865"},{"key":"2933_CR23","doi-asserted-by":"publisher","first-page":"113356","DOI":"10.1016\/jexpneurol2020113356","volume":"202","author":"C Perez-Fernandez","year":"2020","unstructured":"Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Gim\u00e9nez E, S\u00e1nchez-Santed F (2020) Postnatal exposure to low doses of chlorpyrifos induces long-term effects on 5C-SRTT learning and performance cholinergic and GABAergic systems and BDNF expression. Exp Neurol 202:113356. https:\/\/doi.org\/10.1016\/jexpneurol2020113356","journal-title":"Exp Neurol"},{"issue":"1","key":"2933_CR24","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1476-069X-8-12","volume":"8","author":"A Venerosi","year":"2009","unstructured":"Venerosi A, Ricceri L, Scattoni ML, Calamandrei G (2009) Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups. Environ Health Glob Access Sci Source 8(1):12. https:\/\/doi.org\/10.1186\/1476-069X-8-12","journal-title":"Environ Health Glob Access Sci Source"},{"key":"2933_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/JNEURO202107002","volume":"86","author":"C Perez-Fernandez","year":"2021","unstructured":"Perez-Fernandez C, Morales-Navas M, Guardia-Escote L, Colomina MT, Gim\u00e9nez E, S\u00e1nchez-Santed F (2021) Pesticides and aging: preweaning exposure to chlorpyrifos induces a general hypomotricity state in late-adult rats. NeuroToxicol 86:69\u201377. https:\/\/doi.org\/10.1016\/JNEURO202107002","journal-title":"NeuroToxicol"},{"issue":"5","key":"2933_CR26","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1017\/S1461145710000520","volume":"14","author":"ZH Liu","year":"2011","unstructured":"Liu ZH, Chuang DM, Smith CB (2011) Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome. Int J Neuropsychopharmacol 14(5):618\u2013630. https:\/\/doi.org\/10.1017\/S1461145710000520","journal-title":"Int J Neuropsychopharmacol"},{"key":"2933_CR27","doi-asserted-by":"publisher","first-page":"678","DOI":"10.3389\/fendo201900678","volume":"10","author":"A Leboucher","year":"2019","unstructured":"Leboucher A, Bermudez-Martin P, Mouska X, Amri E-Z, Pisani DF, Davidovic L (2019) Fmr1-deficiency impacts body composition skeleton and bone microstructure in a mouse model of fragile X syndrome. Front Endocrinol 10:678. https:\/\/doi.org\/10.3389\/fendo201900678","journal-title":"Front Endocrinol"},{"key":"2933_CR28","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1016\/JNEUROSCIENCE201106047","volume":"194","author":"M Qin","year":"2011","unstructured":"Qin M, Xia Z, Huang T, Smith CB (2011) Effects of chronic immobilization stress on anxiety-like behavior and basolateral amygdala morphology in fmr1 knockout mice. Neurosci 194:282. https:\/\/doi.org\/10.1016\/JNEUROSCIENCE201106047","journal-title":"Neurosci"},{"issue":"6","key":"2933_CR29","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/J.NEURON.2007.12.001","volume":"56","author":"G D\u00f6len","year":"2007","unstructured":"D\u00f6len G, Osterweil E, Rao BSS, Smith GB, Auerbach BD, Chattarji S, Bear MF (2007) Correction of fragile X syndrome in mice. Neuron 56(6):955. https:\/\/doi.org\/10.1016\/J.NEURON.2007.12.001","journal-title":"Neuron"},{"issue":"9","key":"2933_CR30","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1136\/jmg.30.9.761","volume":"30","author":"BBA de Vries","year":"1993","unstructured":"de Vries BBA, Fryns JP, Butler MG, Canziani F, Wesby-van Swaay E, van Hemel JO, Oostra BA, Halley DJJ, Niermeijer MF (1993) Clinical and molecular studies in fragile X patients with a Prader-Willi-like phenotype. J Med Genet 30(9):761\u2013766. https:\/\/doi.org\/10.1136\/jmg.30.9.761","journal-title":"J Med Genet"},{"issue":"4","key":"2933_CR31","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j1399-00041994tb04018x","volume":"45","author":"C Schrander-Stumpel","year":"1994","unstructured":"Schrander-Stumpel C, Gerver W\u2010J, Engelen J, Mulder H, Fryns J\u2010P (1994) Prader-Willi-like phenotype in fragile X syndrome. Clin Genet 45(4):175\u2013180. https:\/\/doi.org\/10.1111\/j1399-00041994tb04018x","journal-title":"Clin Genet"},{"issue":"3","key":"2933_CR32","doi-asserted-by":"publisher","first-page":"216","DOI":"10.2174\/138920211795677886","volume":"12","author":"Y McLennan","year":"2011","unstructured":"McLennan Y, Polussa J, Tassone F, Hagerman R (2011) Fragile X Syndrome. Curr Genomics 12(3):216\u2013224. https:\/\/doi.org\/10.2174\/138920211795677886","journal-title":"Curr Genomics"},{"issue":"6","key":"2933_CR33","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1037\/0735-704412061367","volume":"120","author":"J Moon","year":"2006","unstructured":"Moon J, Beaudin AE, Verosky S, Driscoll LL, Weiskopf M, Levitsky DA, Crnic LS, Strupp BJ (2006) Attentional dysfunction impulsivity and resistance to change in a mouse model of fragile X syndrome. Behav Neurosci 120(6):1367\u20131379. https:\/\/doi.org\/10.1037\/0735-704412061367","journal-title":"Behav Neurosci"},{"key":"2933_CR34","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.neuroscience.2018.05.040","volume":"384","author":"AE Bausch","year":"2018","unstructured":"Bausch AE, Ehinger R, Straubinger J, Zerfass P, Nann Y, Lukowski R (2018) Loss of sodium-activated potassium channel slack and FMRP differentially affect social behavior in mice. Neuroscience 384:361\u2013374. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.05.040","journal-title":"Neuroscience"},{"issue":"6","key":"2933_CR35","doi-asserted-by":"publisher","first-page":"962","DOI":"10.1037\/a0025920","volume":"125","author":"S Roy","year":"2011","unstructured":"Roy S, Zhao Y, Allensworth M, Farook MF, LeDoux MS, Reiter LT, Heck DH (2011) Comprehensive motor testing in fmr1-KO mice exposes temporal defects in oromotor coordination. Behav Neurosci 125(6):962\u2013969. https:\/\/doi.org\/10.1037\/a0025920","journal-title":"Behav Neurosci"},{"key":"2933_CR36","doi-asserted-by":"publisher","unstructured":"Schiavi S, Carbone E, Melancia F, Buzzelli V, Manduca A, Campolongo P, Pallottini V, Trezza V (2020) Perinatal supplementation with omega-3 fatty acids corrects the aberrant social and cognitive traits observed in a genetic model of autism based on FMR1 deletion in rats. Nutr Neurosci https:\/\/doi.org\/10.1080\/1028415X20201819107","DOI":"10.1080\/1028415X20201819107"},{"key":"2933_CR37","doi-asserted-by":"publisher","unstructured":"Tian Y, Yang C, Shang S, Cai Y, Deng X, Zhang J, Shao F, Zhu D, Liu Y, Chen G, Liang J, Sun Q, Qiu Z, Zhang C (2017) Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Front Mol Neurosci 10 https:\/\/doi.org\/10.3389\/fnmol201700269","DOI":"10.3389\/fnmol201700269"},{"key":"2933_CR38","doi-asserted-by":"publisher","unstructured":"Asiminas A, Jackson AD, Louros SR, Till SM, Spano T, Dando O, Bear MF, Chattarji S, Hardingham GE, Osterweil EK, Wyllie DJA, Wood ER, Kind PC (2019) Sustained correction of associative learning deficits after brief early treatment in a rat model of fragile X syndrome. Sci Transl Med 11(494). https:\/\/doi.org\/10.1126\/scitranslmed.aao0498","DOI":"10.1126\/scitranslmed.aao0498"},{"key":"2933_CR39","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1098\/rspb20180294","volume":"285","author":"K Saxena","year":"2018","unstructured":"Saxena K, Webster J, Hallas-Potts A, Mackenzie R, Spooner PA, Thomson D, Kind P, Chatterji S, Morris RGM (2018) Experiential contributions to social dominance in a rat model of fragile-X syndrome. Proc R Soc B Biol Sci 285:1880. https:\/\/doi.org\/10.1098\/rspb20180294","journal-title":"Proc R Soc B Biol Sci"},{"issue":"1","key":"2933_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00213-011-2375-4","volume":"219","author":"AM Thomas","year":"2012","unstructured":"Thomas AM, Bui N, Perkins JR, Yuva-Paylor LA, Paylor R (2012) Group i metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome. Psychopharmacology 219(1):47\u201358. https:\/\/doi.org\/10.1007\/s00213-011-2375-4","journal-title":"Psychopharmacology"},{"issue":"6","key":"2933_CR41","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1111\/J.1601-183X.2010.00585.X","volume":"9","author":"KB Baker","year":"2010","unstructured":"Baker KB, Wray SP, Ritter R, Mason S, Lanthorn TH, Savelieva KV (2010) Male and female Fmr1 knockout mice on C57 albino background exhibit spatial learning and memory impairments. Genes Brain Behav 9(6):562\u2013574. https:\/\/doi.org\/10.1111\/J.1601-183X.2010.00585.X","journal-title":"Genes Brain Behav"},{"key":"2933_CR42","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/jbbr201403013","volume":"267","author":"AJ Renoux","year":"2014","unstructured":"Renoux AJ, Sala-Hamrick KJ, Carducci NM, Frazer M, Halsey KE, Sutton MA, Dolan DF, Murphy GG, Todd PK (2014) Impaired sensorimotor gating in Fmr1 knock out and fragile X premutation model mice. Behav Brain Res 267:42\u201345. https:\/\/doi.org\/10.1016\/jbbr201403013","journal-title":"Behav Brain Res"},{"issue":"1","key":"2933_CR43","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.nbd.2008.04.002","volume":"31","author":"FMS de Vrij","year":"2008","unstructured":"de Vrij FMS, Levenga J, van der Linde HC, Koekkoek SK, De Zeeuw CI, Nelson DL, Oostra BA, Willemsen R (2008) Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice. Neurobiol Dis 31(1):127\u2013132. https:\/\/doi.org\/10.1016\/j.nbd.2008.04.002","journal-title":"Neurobiol Dis"},{"issue":"12","key":"2933_CR44","doi-asserted-by":"publisher","first-page":"1984","DOI":"10.1093\/hmg\/ddl121","volume":"15","author":"CM Spencer","year":"2006","unstructured":"Spencer CM, Serysheva E, Yuva-Paylor LA, Oostra BA, Nelson DL, Paylor R (2006) Exaggerated behavioral phenotypes in Fmr1\/Fxr2 double knockout mice reveal a functional genetic interaction between fragile X-related proteins. Human Mol Genet 15(12):1984\u20131994. https:\/\/doi.org\/10.1093\/hmg\/ddl121","journal-title":"Human Mol Genet"},{"key":"2933_CR45","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/jbrainres201905029","volume":"1719","author":"J Kokash","year":"2019","unstructured":"Kokash J, Alderson EM, Reinhard SM, Crawford CA, Binder DK, Ethell IM, Razak KA (2019) Genetic reduction of MMP-9 in the Fmr1 KO mouse partially rescues prepulse inhibition of acoustic startle response. Brain Res 1719:24\u201329. https:\/\/doi.org\/10.1016\/jbrainres201905029","journal-title":"Brain Res"},{"key":"2933_CR46","doi-asserted-by":"publisher","first-page":"109341","DOI":"10.1016\/jenvres2020109341","volume":"184","author":"C Perez-Fernandez","year":"2020","unstructured":"Perez-Fernandez C, Morales-Navas M, Aguilera-S\u00e1ez LM, Abreu AC, Guardia-Escote L, Fern\u00e1ndez I, Garrido-C\u00e1rdenas JA, Colomina MT, Gim\u00e9nez E, S\u00e1nchez-Santed F (2020) Medium and long-term effects of low doses of chlorpyrifos during the postnatal preweaning developmental stage on sociability dominance gut microbiota and plasma metabolites. Environ Res 184:109341. https:\/\/doi.org\/10.1016\/jenvres2020109341","journal-title":"Environ Res"},{"key":"2933_CR47","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/jbrainres201112041","volume":"1439","author":"SE Rotschafer","year":"2012","unstructured":"Rotschafer SE, Trujillo MS, Dansie LE, Ethell IM, Razak KA (2012) Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of fragile X Syndrome. Brain Res 1439:7\u201314. https:\/\/doi.org\/10.1016\/jbrainres201112041","journal-title":"Brain Res"},{"key":"2933_CR48","doi-asserted-by":"publisher","first-page":"112068","DOI":"10.1016\/jbbr2019112068","volume":"372","author":"MA Toledo","year":"2019","unstructured":"Toledo MA, Wen TH, Binder DK, Ethell IM, Razak KA (2019) Reversal of ultrasonic vocalization deficits in a mouse model of fragile X syndrome with minocycline treatment or genetic reduction of MMP-9. Behav Brain Res 372:112068. https:\/\/doi.org\/10.1016\/jbbr2019112068","journal-title":"Behav Brain Res"},{"key":"2933_CR49","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/jbbr201310049","volume":"259","author":"JKY Lai","year":"2014","unstructured":"Lai JKY, Sobala-Drozdowski M, Zhou L, Doering LC, Faure PA, Foster JA (2014) Temporal and spectral differences in the ultrasonic vocalizations of fragile X knock out mice during postnatal development. Behav Brain Res 259:119\u2013130. https:\/\/doi.org\/10.1016\/jbbr201310049","journal-title":"Behav Brain Res"},{"key":"2933_CR50","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.bbr.2016.04.016","volume":"310","author":"AP Belagodu","year":"2016","unstructured":"Belagodu AP, Johnson AM, Galvez R (2016) Characterization of ultrasonic vocalizations of fragile X mice. Behav Brain Res 310:76\u201383. https:\/\/doi.org\/10.1016\/j.bbr.2016.04.016","journal-title":"Behav Brain Res"},{"key":"2933_CR51","doi-asserted-by":"publisher","unstructured":"Nolan SO, Hodges SL, Lugo JN (2020) High-throughput analysis of vocalizations reveals sex-specific changes in Fmr1 mutant pups. Genes Brain Behav 19(2) https:\/\/doi.org\/10.1111\/gbb12611","DOI":"10.1111\/gbb12611"},{"key":"2933_CR52","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/jbbr201705052","volume":"332","author":"SL Hodges","year":"2017","unstructured":"Hodges SL, Nolan SO, Reynolds CD, Lugo JN (2017) Spectral and temporal properties of calls reveal deficits in ultrasonic vocalizations of adult Fmr1 knockout mice. Behav Brain Res 332:50\u201358. https:\/\/doi.org\/10.1016\/jbbr201705052","journal-title":"Behav Brain Res"},{"key":"2933_CR53","doi-asserted-by":"publisher","unstructured":"Pietropaolo S, Guilleminot A, Martin B, D\u2019Amato FR, Crusio WE (2011) Genetic-background modulation of core and variable autistic-like symptoms in Fmr1 knock-out mice. PLoS One 6(2) https:\/\/doi.org\/10.1371\/journalpone0017073","DOI":"10.1371\/journalpone0017073"},{"key":"2933_CR54","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/JNEURO201601008","volume":"53","author":"W Saldarriaga","year":"2016","unstructured":"Saldarriaga W, Lein P, Teshima LYG, Isaza C, Rosa L, Polyak A, Hagerman R, Girirajan S, Silva M, Tassone F (2016) Phenobarbital use and neurological problems in FMR1 premutation carriers. Neurotoxicology 53:141. https:\/\/doi.org\/10.1016\/JNEURO201601008","journal-title":"Neurotoxicology"},{"key":"2933_CR55","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/FNMOL.2018.00353","volume":"0","author":"L Costa","year":"2018","unstructured":"Costa L, Sardone LM, Bonaccorso CM, D\u2019Antoni S, Spatuzza M, Gulisano W, Tropea MR, Puzzo D, Leopoldo M, Lacivita E, Catania MV, Ciranna L (2018) Activation of serotonin 5-HT7 receptors modulates hippocampal synaptic plasticity by stimulation of adenylate cyclases and rescues learning and behavior in a mouse model of fragile X syndrome. Front Mol Neurosci 0:353. https:\/\/doi.org\/10.3389\/FNMOL.2018.00353","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"2933_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-021-21820-1","volume":"12","author":"M Prieto","year":"2021","unstructured":"Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, Fran\u00e7ois U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, Chafai M, Khayachi A, Gwizdek C, Brau F, Deval E, Francolini M, Bardoni B, Humeau Y, Martin S (2021) Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice. Nat Commun 12(1):1\u201315. https:\/\/doi.org\/10.1038\/s41467-021-21820-1","journal-title":"Nat Commun"},{"issue":"11","key":"2933_CR57","doi-asserted-by":"publisher","first-page":"1782","DOI":"10.2522\/PTJ20140430","volume":"96","author":"C Lieb-Lundell","year":"2016","unstructured":"Lieb-Lundell C (2016) Three faces of fragile X. Physical Therapy 96(11):1782\u20131790. https:\/\/doi.org\/10.2522\/PTJ20140430","journal-title":"Physical Therapy"},{"issue":"11","key":"2933_CR58","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1002\/AUR.1829","volume":"10","author":"D Garrido","year":"2017","unstructured":"Garrido D, Petrova D, Watson LR, Garcia-Retamero R, Carballo G (2017) Language and motor skills in siblings of children with autism spectrum disorder: a meta-analytic review. Autism Res 10(11):1737\u20131750. https:\/\/doi.org\/10.1002\/AUR.1829","journal-title":"Autism Res"},{"issue":"27","key":"2933_CR59","doi-asserted-by":"publisher","first-page":"11489","DOI":"10.1073\/PNAS0705003104","volume":"104","author":"ML Hayashi","year":"2007","unstructured":"Hayashi ML, Rao BSS, Seo J-S, Choi H-S, Dolan BM, Choi S-Y, Chattarji S, Tonegawa S (2007) Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice. Proc Natl Acad Sci U S A 104(27):11489. https:\/\/doi.org\/10.1073\/PNAS0705003104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"2933_CR60","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/J1601-183X201200784X","volume":"11","author":"M Uutela","year":"2012","unstructured":"Uutela M, Lindholm J, Louhivuori V, Wei H, Louhivuori LM, Pertovaara A, \u00c5kerman K, Castr\u00e9n E, Castr\u00e9n ML (2012) Reduction of BDNF expression in Fmr1 knockout mice worsens cognitive deficits but improves hyperactivity and sensorimotor deficits. Genes Brain Behav 11(5):513\u2013523. https:\/\/doi.org\/10.1111\/J1601-183X201200784X","journal-title":"Genes Brain Behav"},{"key":"2933_CR61","doi-asserted-by":"publisher","unstructured":"Uutela M, Lindholm J, Rantam\u00e4ki T, Umemori J, Hunter K, V\u00f5ikar V, Castr\u00e9n ML (2014) Distinctive behavioral and cellular responses to fluoxetine in the mouse model for fragile X syndrome. Front Cell Neurosci 8 https:\/\/doi.org\/10.3389\/FNCEL201400150","DOI":"10.3389\/FNCEL201400150"},{"key":"2933_CR62","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/J.NEUROSCIENCE.2013.04.058","volume":"246","author":"LE Dansie","year":"2013","unstructured":"Dansie LE, Phommahaxay K, Okusanya AG, Uwadia J, Huang M, Rotschafer SE, Razak KA, Ethell DW, Ethell IM (2013) Long-lasting effects of minocycline on behavior in young but not adult fragile X mice. Neuroscience 246:186\u2013198. https:\/\/doi.org\/10.1016\/J.NEUROSCIENCE.2013.04.058","journal-title":"Neuroscience"},{"issue":"5","key":"2933_CR63","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/NPP2014291","volume":"40","author":"D Oddi","year":"2015","unstructured":"Oddi D, Subashi E, Middei S, Bellocchio L, Lemaire-Mayo V, Guzm\u00e1n M, Crusio WE, D\u2019Amato FR, Pietropaolo S (2015) Early social enrichment rescues adult behavioral and brain abnormalities in a mouse model of fragile X syndrome. Neuropsychopharmacology 40(5):1113. https:\/\/doi.org\/10.1038\/NPP2014291","journal-title":"Neuropsychopharmacology"},{"key":"2933_CR64","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/JBBR201606024","volume":"312","author":"G Qiu","year":"2016","unstructured":"Qiu G, Chen S, Guo J, Wu J, Yi YH (2016) Alpha-asarone improves striatal cholinergic function and locomotor hyperactivity in Fmr1 knockout mice. Behav Brain Res 312:212\u2013218. https:\/\/doi.org\/10.1016\/JBBR201606024","journal-title":"Behav Brain Res"},{"key":"2933_CR65","doi-asserted-by":"publisher","unstructured":"Schaefer TL, Davenport MH, Grainger LM, Robinson CK, Earnheart AT, Stegman MS, Lang AL, Ashworth AA, Molinaro G, Huber KM, Erickson CA (2017) Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity ERK1\/2 activation locomotor behavior and anxiety. J Neurodevelopmental Disord 9(1) https:\/\/doi.org\/10.1186\/S11689-017-9184-Y","DOI":"10.1186\/S11689-017-9184-Y"},{"key":"2933_CR66","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/J.NEUROPHARM.2017.09.026","volume":"128","author":"M Chatterjee","year":"2018","unstructured":"Chatterjee M, Kurup PK, Lundbye CJ, Hugger Toft AK, Kwon J, Benedict J, Kamceva M, Banke TG, Lombroso PJ (2018) STEP inhibition reverses behavioral electrophysiologic and synaptic abnormalities in Fmr1 KO mice. Neuropharmacology 128:43\u201353. https:\/\/doi.org\/10.1016\/J.NEUROPHARM.2017.09.026","journal-title":"Neuropharmacology"},{"issue":"5","key":"2933_CR67","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1111\/JNC15037","volume":"155","author":"PS Pirbhoy","year":"2020","unstructured":"Pirbhoy PS, Rais M, Lovelace JW, Woodard W, Razak KA, Binder DK, Ethell IM (2020) Acute pharmacological inhibition of matrix metalloproteinase-9 activity during development restores perineuronal net formation and normalizes auditory processing in Fmr1 KO mice. J Neurochem 155(5):538\u2013558. https:\/\/doi.org\/10.1111\/JNC15037","journal-title":"J Neurochem"},{"key":"2933_CR68","doi-asserted-by":"publisher","unstructured":"Kozono NO, Kamura A, Honda S, Matsumoto M, Mihara T (2020) Gamma power abnormalities in a Fmr1-targeted transgenic rat model of fragile X syndrome. Sci Rep 10(1) https:\/\/doi.org\/10.1038\/S41598-020-75893-X","DOI":"10.1038\/S41598-020-75893-X"},{"key":"2933_CR69","doi-asserted-by":"publisher","unstructured":"Wong H, Hooper AWM, Niibori Y, Lee SJ, Hategan LA, Zhang LZ, Karumuthil-Melethil S, Sally M, Till SM, Peter C, Kind PC, Olivier Danos O, Bruder JT, Hampson DR (2020) Sexually dimorphic patterns in electroencephalography power spectrum and autism-related behaviors in a rat model of fragile X syndrome. Neurobiol Dis 146 https:\/\/doi.org\/10.1016\/JNBD2020105118","DOI":"10.1016\/JNBD2020105118"},{"key":"2933_CR70","doi-asserted-by":"publisher","unstructured":"Fish EW, Krouse MC, Stringfield SJ, Diberto JF, Robinson JE, Malanga CJ (2013) Changes in sensitivity of reward and motor behavior to dopaminergic glutamatergic and cholinergic drugs in a mouse model of fragile X syndrome. PloS One 8(10). https:\/\/doi.org\/10.1371\/JOURNAL.PONE.0077896","DOI":"10.1371\/JOURNAL.PONE.0077896"},{"issue":"1","key":"2933_CR71","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/S41398-017-0061-Y","volume":"8","author":"Y Yu","year":"2018","unstructured":"Yu Y, Lin Y, Takasaki Y, Wang C, Kimura H, Xing J, Ishizuka K, Toyama M, Kushima I, Mori D, Arioka Y, Uno Y, Shiino T, Nakamura Y, Okada T, Morikawa M, Ikeda M, Iwata N, Okahisa Y, Ozaki N (2018) Rare loss of function mutations in N-methyl-d-aspartate glutamate receptors and their contributions to schizophrenia susceptibility Translational. Psychiatry 8(1):12. https:\/\/doi.org\/10.1038\/S41398-017-0061-Y","journal-title":"Psychiatry"},{"issue":"6","key":"2933_CR72","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1113\/JPHYSIOL.2008.150722","volume":"586","author":"G D\u00f6len","year":"2008","unstructured":"D\u00f6len G, Bear MF (2008) Role for metabotropic glutamate receptor 5 (mGluR5) in the pathogenesis of fragile X syndrome. J Physiol 586(6):1503\u20131508. https:\/\/doi.org\/10.1113\/JPHYSIOL.2008.150722","journal-title":"J Physiol"},{"key":"2933_CR73","doi-asserted-by":"publisher","unstructured":"Yau S-Y, Bettio L, Chiu J, Chiu C, Christie BR (2019) Fragile-X syndrome is associated with NMDA receptor hypofunction and reduced dendritic complexity in mature dentate granule cells. Front Mol Neurosci 11 https:\/\/doi.org\/10.3389\/FNMOL201800495","DOI":"10.3389\/FNMOL201800495"},{"key":"2933_CR74","doi-asserted-by":"publisher","unstructured":"Banke TG, Barria A (2020) Transient enhanced GluA2 expression in young hippocampal neurons of a fragile X mouse model. Front Synaptic Neurosci 12. https:\/\/doi.org\/10.3389\/FNSYN.2020.588295","DOI":"10.3389\/FNSYN.2020.588295"},{"issue":"1","key":"2933_CR75","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1093\/CERCOR\/BHT237","volume":"25","author":"CA Bostrom","year":"2015","unstructured":"Bostrom CA, Majaess N-M, Morch K, White E, Eadie BD, Christie BR (2015) Rescue of NMDAR-dependent synaptic plasticity in Fmr1 knock-out mice. Cereb Cortex 25(1):271\u2013279. https:\/\/doi.org\/10.1093\/CERCOR\/BHT237","journal-title":"Cereb Cortex"},{"issue":"2","key":"2933_CR76","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1111\/JNC14970","volume":"154","author":"M Vieira","year":"2020","unstructured":"Vieira M, Yong XLH, Roche KW, Anggono V (2020) Regulation of NMDA glutamate receptor functions by the GluN2 subunits. J Neurochem 154(2):121\u2013143. https:\/\/doi.org\/10.1111\/JNC14970","journal-title":"J Neurochem"},{"issue":"16","key":"2933_CR77","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.2174\/1568026619666190709101449","volume":"19","author":"EA Wold","year":"2019","unstructured":"Wold EA, Wild CT, Cunningham KA, Zhou J (2019) Targeting the 5-HT2C receptor in biological context and the current state of 5-HT2C receptor ligand development. Curr Topics Med Chem 19(16):1381. https:\/\/doi.org\/10.2174\/1568026619666190709101449","journal-title":"Curr Topics Med Chem"},{"issue":"S1","key":"2933_CR78","doi-asserted-by":"publisher","first-page":"6671","DOI":"10.1096\/FASEBJ2019331_SUPPLEMENT6671","volume":"33","author":"J Prophitt","year":"2019","unstructured":"Prophitt J, Armstrong J, Chen Y, Canal C (2019) Assessment of brain serotonin receptors in an Fmr1 knockout mouse model of fragile X syndrome. FASEB J 33(S1):6671\u20136671. https:\/\/doi.org\/10.1096\/FASEBJ2019331_SUPPLEMENT6671","journal-title":"FASEB J"},{"key":"2933_CR79","doi-asserted-by":"publisher","unstructured":"Saraf T, Chen Y, Armstrong JL, Prophitt J, Canal C (2021) Evaluation of Serotonin 5-HT1A 5-HT2A and 5-HT2C receptors and the serotonin transporter in an Fmr1 knockout mouse model of fragile X syndrome. FASEB J 35(S1) https:\/\/doi.org\/10.1096\/FASEBJ202135S103781","DOI":"10.1096\/FASEBJ202135S103781"},{"key":"2933_CR80","doi-asserted-by":"publisher","unstructured":"Garneau AP, Slimani S, Tremblay LE, Fiola MJ, Marcoux AA, Isenring P (2019) K+-Cl- cotransporter 1 (KCC1): A housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells. J Hematol Oncol 12(1). https:\/\/doi.org\/10.1186\/S13045-019-0766-X","DOI":"10.1186\/S13045-019-0766-X"},{"issue":"1","key":"2933_CR81","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1016\/S0165-3806(02)00536-9","volume":"139","author":"C Wang","year":"2002","unstructured":"Wang C, Shimizu-Okabe C, Watanabe K, Okabe A, Matsuzaki H, Ogawa T, Mori N, Fukuda A, Sato K (2002) Developmental changes in KCC1 KCC2 and NKCC1 mRNA expressions in the rat brain. Dev Brain Res 139(1):59\u201366. https:\/\/doi.org\/10.1016\/S0165-3806(02)00536-9","journal-title":"Dev Brain Res"},{"key":"2933_CR82","unstructured":"Lydiard RB (2003) The role of GABA in anxiety disorders. J Clin Psychiatry 2003 64(suppl 3)."},{"issue":"8","key":"2933_CR83","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/sjmp4001845","volume":"11","author":"JM Hettema","year":"2006","unstructured":"Hettema JM, An SS, Neale MC, Bukszar J, van den Oord EJC, Kendler G, KS, Chen X, (2006) Association between glutamic acid decarboxylase genes and anxiety disorders major depression and neuroticism. Mol Psychiatry 11(8):752\u2013762. https:\/\/doi.org\/10.1038\/sjmp4001845","journal-title":"Mol Psychiatry"},{"issue":"2","key":"2933_CR84","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/J.PHARMTHERA.2012.08.006","volume":"136","author":"E Engin","year":"2012","unstructured":"Engin E, Liu J, Rudolph U (2012) \u03b12-containing GABAA receptors: a target for the development of novel treatment strategies for CNS disorders. Pharmacol Ther 136(2):142. https:\/\/doi.org\/10.1016\/J.PHARMTHERA.2012.08.006","journal-title":"Pharmacol Ther"},{"issue":"Suppl 4","key":"2933_CR85","doi-asserted-by":"publisher","first-page":"S443","DOI":"10.33549\/PHYSIOLRES933796","volume":"66","author":"J Myslivecek","year":"2017","unstructured":"Myslivecek J, Farar V, Valuskova P (2017) M(4) muscarinic receptors and locomotor activity regulation. Physiol Res 66(Suppl 4):S443\u2013S455. https:\/\/doi.org\/10.33549\/PHYSIOLRES933796","journal-title":"Physiol Res"},{"issue":"1","key":"2933_CR86","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1756-6606-5-10","volume":"5","author":"H Koshimizu","year":"2012","unstructured":"Koshimizu H, Leiter LM, Miyakawa T (2012) M 4 muscarinic receptor knockout mice display abnormal social behavior and decreased prepulse inhibition. Mol Brain 5(1):1\u201310. https:\/\/doi.org\/10.1186\/1756-6606-5-10","journal-title":"Mol Brain"},{"key":"2933_CR87","doi-asserted-by":"publisher","first-page":"172916","DOI":"10.1016\/JPBB2020172916","volume":"193","author":"G Unal","year":"2020","unstructured":"Unal G, Bekci H, Cumaoglu A, Yerer MB, Aricioglu F (2020) Alpha 7 nicotinic receptor agonist and positive allosteric modulators improved social and molecular deficits of MK-801 model of schizophrenia in rats. Pharmacol Biochem Behav 193:172916. https:\/\/doi.org\/10.1016\/JPBB2020172916","journal-title":"Pharmacol Biochem Behav"},{"key":"2933_CR88","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/JNEUROPHARM201301014","volume":"70","author":"AL Halberstadt","year":"2013","unstructured":"Halberstadt AL, Powell SB, Geyer MA (2013) Role of the 5-HT2A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology 70:218. https:\/\/doi.org\/10.1016\/JNEUROPHARM201301014","journal-title":"Neuropharmacology"},{"issue":"8","key":"2933_CR89","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1038\/npp200929","volume":"34","author":"AL Halberstadt","year":"2009","unstructured":"Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell SB (2009) 5-HT2A and 5-HT2C receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology 34(8):1958\u20131967. https:\/\/doi.org\/10.1038\/npp200929","journal-title":"Neuropsychopharmacology"},{"issue":"7","key":"2933_CR90","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1136\/JMEDGENET-2016-104509","volume":"54","author":"K Platzer","year":"2017","unstructured":"Platzer K, Yuan H, Sch\u00fctz H, Winschel A, Chen W, Hu C, Kusumoto H, Heyne HO, Helbig KL, Tang S, Willing MC, Tinkle BT, Adams DJ, Depienne C, Keren B, Mignot C, Frengen E, Str\u00f8mme P, Biskup S, Lemke JR (2017) GRIN2B encephalopathy: novel findings on phenotype variant clustering functional consequences and treatment aspects. J Med Genet 54(7):460\u2013470. https:\/\/doi.org\/10.1136\/JMEDGENET-2016-104509","journal-title":"J Med Genet"},{"key":"2933_CR91","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/JPHYSBEH201605047","volume":"164","author":"K Narita","year":"2016","unstructured":"Narita K, Murata T, Matsuoka S (2016) The ventromedial hypothalamus oxytocin induces locomotor behavior regulated by estrogen. Physiol Behav 164:107\u2013112. https:\/\/doi.org\/10.1016\/JPHYSBEH201605047","journal-title":"Physiol Behav"},{"issue":"1","key":"2933_CR92","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41467-017-02173-0","volume":"8","author":"T Raam","year":"2017","unstructured":"Raam T, McAvoy KM, Besnard A, Veenema AH, Sahay A (2017) Hippocampal oxytocin receptors are necessary for discrimination of social stimuli Nature. Communications 8(1):1\u201314. https:\/\/doi.org\/10.1038\/s41467-017-02173-0","journal-title":"Communications"},{"issue":"1\u20132","key":"2933_CR93","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/J.JPHYSPARIS.2016.11.010","volume":"110","author":"M Chamoun","year":"2016","unstructured":"Chamoun M, Groleau M, Bhat M (2016) Dose-dependent effect of donepezil administration on long-term enhancement of visually evoked potentials and cholinergic receptor overexpression in rat visual cortex. J Phys Paris 110(1\u20132):65\u201374. https:\/\/doi.org\/10.1016\/J.JPHYSPARIS.2016.11.010","journal-title":"J Phys Paris"},{"issue":"24\u201325","key":"2933_CR94","doi-asserted-by":"publisher","first-page":"2263","DOI":"10.1016\/jlfs200701026","volume":"80","author":"KS Lips","year":"2007","unstructured":"Lips KS, L\u00fchrmann A, Tschernig T, Stoeger T, Alessandrini F, Grau V, Haberberger RV, Koepsell H, Pabst R, Kummer W (2007) Down-regulation of the non-neuronal acetylcholine synthesis and release machinery in acute allergic airway inflammation of rat and mouse. Life Sci 80(24\u201325):2263\u20132269. https:\/\/doi.org\/10.1016\/jlfs200701026","journal-title":"Life Sci"},{"issue":"1","key":"2933_CR95","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1289\/ehp9487","volume":"115","author":"RR Jameson","year":"2007","unstructured":"Jameson RR, Seidler FJ, Slotkin TA (2007) Nonenzymatic functions of acetylcholinesterase splice variants in the developmental neurotoxicity of organophosphates: chlorpyrifos, chlorpyrifos oxon, and diazinon. Environ Health Perspect 115(1):65\u201370. https:\/\/doi.org\/10.1289\/ehp9487","journal-title":"Environ Health Perspect"},{"issue":"1","key":"2933_CR96","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.molbrainres.2005.03.013","volume":"138","author":"J Fujimura","year":"2005","unstructured":"Fujimura J, Nagano M, Suzuki H (2005) Differential expression of GABAA receptor subunits in the distinct nuclei of the rat amygdala. Mol Brain Res 138(1):17\u201323. https:\/\/doi.org\/10.1016\/j.molbrainres.2005.03.013","journal-title":"Mol Brain Res"},{"issue":"3","key":"2933_CR97","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.1161\/STROKEAHA109570424","volume":"41","author":"N Jaenisch","year":"2010","unstructured":"Jaenisch N, Witte OW, Frahm C (2010) Downregulation of potassium chloride cotransporter KCC2 after transient focal cerebral ischemia. Stroke 41(3):e151-9. https:\/\/doi.org\/10.1161\/STROKEAHA109570424","journal-title":"Stroke"},{"issue":"7","key":"2933_CR98","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1097\/HJH.0b013e3283610fed","volume":"31","author":"H-M Cho","year":"2013","unstructured":"Cho H-M, Lee H-A, Kim HY, Lee D-Y, Kim IK (2013) Recruitment of specificity protein 1 by CpG hypomethylation upregulates Na+-K+-2Cl\u2212 cotransporter 1 in hypertensive rats. J Hypertens 31(7):1406\u20131413. https:\/\/doi.org\/10.1097\/HJH.0b013e3283610fed","journal-title":"J Hypertens"},{"issue":"4","key":"2933_CR99","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/jneuropharm200605026","volume":"51","author":"AMS Kindlundh-H\u00f6gberg","year":"2006","unstructured":"Kindlundh-H\u00f6gberg AMS, Svenningsson P, Schi\u00f6th HB (2006) Quantitative mapping shows that serotonin rather than dopamine receptor mRNA expressions are affected after repeated intermittent administration of MDMA in rat brain. Neuropharmacology 51(4):838\u2013847. https:\/\/doi.org\/10.1016\/jneuropharm200605026","journal-title":"Neuropharmacology"},{"key":"2933_CR100","first-page":"1538","volume":"19","author":"JC Lau","year":"2013","unstructured":"Lau JC, Kroes RA, Moskal JR, Linsenmeier RA (2013) Diabetes changes expression of genes related to glutamate neurotransmission and transport in the Long-Evans rat retina. Mol vision 19:1538\u20131553","journal-title":"Mol vision"},{"issue":"2","key":"2933_CR101","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1007\/S12031-018-1233-9","volume":"67","author":"EV Pershina","year":"2018","unstructured":"Pershina EV, Mikheeva IB, Kamaltdinova ER, Arkhipov VI (2018) Expression of mGlu receptor genes in the hippocampus after intoxication with trimethyltin. J Mol Neurosci 67(2):258\u2013264. https:\/\/doi.org\/10.1007\/S12031-018-1233-9","journal-title":"J Mol Neurosci"},{"issue":"2","key":"2933_CR102","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1037\/A0035988","volume":"128","author":"SM Hamilton","year":"2014","unstructured":"Hamilton SM, Green JR, Veeraragavan S et al (2014) Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders. Behav Neurosci 128(2):103\u2013109. https:\/\/doi.org\/10.1037\/A0035988","journal-title":"Behav Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02933-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-022-02933-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-022-02933-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,22]],"date-time":"2022-08-22T14:06:28Z","timestamp":1661177188000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-022-02933-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,8]]},"references-count":102,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["2933"],"URL":"https:\/\/doi.org\/10.1007\/s12035-022-02933-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,8]]},"assertion":[{"value":"7 March 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 June 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The present study is part of the project ES040130002260 and was conducted following the Spanish Royal Decree 53\/2013, the European Community Directive (2010\/63\/EU) for animal research and complies with the ARRIVE guidelines for animal research. The Animal Research Committee of the University of Almeria approved the experiments described here.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}