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Ethical approval for the human portion of this study was granted by the St Patrick\u2019s University Hospital Research Ethics Committee in Dublin (Protocol No. 012\/07) and the local ethics committee in Mannheim, Germany. The human studies were performed in accordance with the Declaration of Helsinki.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Written informed consent was obtained from all individual participants included in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"DMM has received speaker\u2019s honoraria from MECTA and Otsuka and an honorarium from Janssen for participating in an esketamine advisory board meeting. KR, LK, AS, PS, GB, and OS have no competing interests to declare.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}