{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T05:49:52Z","timestamp":1747288192287,"version":"3.37.3"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T00:00:00Z","timestamp":1674172800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004077","name":"Kocaeli \u00dcniversitesi","doi-asserted-by":"publisher","award":["2013\/155"],"award-info":[{"award-number":["2013\/155"]}],"id":[{"id":"10.13039\/501100004077","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s12035-023-03220-2","type":"journal-article","created":{"date-parts":[[2023,1,20]],"date-time":"2023-01-20T22:06:26Z","timestamp":1674252386000},"page":"2442-2454","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Letrozole Decreased Testosterone-Induced Cell Proliferation and Prolactin Secretion also Increased Apoptosis in MMQ and GH3 Rat Prolactinoma Cell Lines"],"prefix":"10.1007","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-8697","authenticated-orcid":false,"given":"Alev","family":"Selek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zehra Seda Unal","family":"Halbuto\u011fullar\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c7i\u011fdem \u0130nci","family":"Aydemir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berrin","family":"Cetinarslan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Canturk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilhan","family":"Tarkun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclay","family":"Erman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Suba\u015f\u0131","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kara\u00f6z","family":"Erdal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,1,20]]},"reference":[{"issue":"4","key":"3220_CR1","doi-asserted-by":"publisher","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","volume":"80","author":"ME Freeman","year":"2000","unstructured":"Freeman ME, Kanyicska L, Lerant A, Gy A, Nagy R, Kanyicska B et al (2000) Prolactin: structure, function, and regulation of secretion. Physiol Rev 80(4):1523\u20131631","journal-title":"Physiol Rev"},{"issue":"2","key":"3220_CR2","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s42000-018-0071-z","volume":"18","author":"G Levin","year":"2018","unstructured":"Levin G (2018) Prolactin, prolactin disorders, and dopaminee agonists during pregnancy. Horm 18(2):137\u2013139","journal-title":"Horm"},{"issue":"11","key":"3220_CR3","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1016\/0024-3205(83)90196-0","volume":"32","author":"N Matsushita","year":"1983","unstructured":"Matsushita N, Kato Y, Shimatsu A, Katakami H, Yanaihara N, Imura H (1983) Effects of VIP, TRH, GABA and dopaminee on prolactin release from superfused rat anterior pituitary cells. Life Sci 32(11):1263\u20131269","journal-title":"Life Sci"},{"issue":"1","key":"3220_CR4","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1210\/endo-93-1-26","volume":"93","author":"W Vale","year":"1973","unstructured":"Vale W, Blackwell R, Grant G, Guillemin R (1973) TRF and thyroid hormones on prolactin secretion by rat anterior pituitary cells in vitro. Endocrinology 93(1):26\u201333","journal-title":"Endocrinology"},{"issue":"2","key":"3220_CR5","doi-asserted-by":"publisher","first-page":"236","DOI":"10.20945\/2359-3997000000032","volume":"62","author":"L Vilar","year":"2018","unstructured":"Vilar L, Abucham J, Albuquerque JL, Araujo LA, Azevedo MF, Boguszewski CL et al (2018) Controversial issues in the management of hyperprolactinemia and prolactinomas \u2013 an overview by the Neuroendocrinology Department of the Brazilian Society of Endocrinology and Metabolism. Arch Endocrinol Metab 62(2):236\u2013263","journal-title":"Arch Endocrinol Metab"},{"issue":"1","key":"3220_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.ecl.2014.11.003","volume":"44","author":"A Glezer","year":"2015","unstructured":"Glezer A, Bronstein MD (2015) Prolactinomas. Endocrinol Metab Clin North Am 44(1):71\u201378","journal-title":"Endocrinol Metab Clin North Am"},{"issue":"3","key":"3220_CR7","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1097\/JIM.0000000000000138","volume":"63","author":"Q Guo","year":"2015","unstructured":"Guo Q, Erickson BJ, Chang \u00deAY, Erickson D (2015) Characteristics of dynamic magnetic resonance \u0131mage enhancement in prolactinomas resistant to dopaminee agonist therapy. J Investig Med 63(3):529\u2013534","journal-title":"J Investig Med"},{"issue":"2","key":"3220_CR8","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1530\/eje.1.02339","volume":"156","author":"A G\u00fcrlek","year":"2007","unstructured":"G\u00fcrlek A, Karavitaki N, Ansorge O, Wass JAH (2007) What are the markers of aggressiveness in prolactinomas? Changes in cell biology, extracellular matrix components, angiogenesis and genetics. Eur J Endocrinol 156(2):143\u201353","journal-title":"Eur J Endocrinol"},{"key":"3220_CR9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1258\/0004563053492784","volume":"42","author":"R Sodi","year":"2005","unstructured":"Sodi R, Fikri R, Diver M, Ranganath L, Vora J (2005) Case report testosterone replacement-induced hyperprolactinaemia\u202f: case report and review of the literature. Ann Clin Biochem 42:153\u2013159","journal-title":"Ann Clin Biochem"},{"issue":"5","key":"3220_CR10","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1007\/BF02442351","volume":"19","author":"HH Goh","year":"1990","unstructured":"Goh HH, Ratnam SS (1990) Effect of estrogens on prolactin secretion in transsexual subjects. Arch Sex Behav 19(5):507\u2013516","journal-title":"Arch Sex Behav"},{"issue":"1","key":"3220_CR11","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s00210-016-1310-y","volume":"390","author":"M S\u00e1nchez","year":"2017","unstructured":"S\u00e1nchez M, Su\u00e1rez L, Cantabrana B, Bordallo J (2017) Estradiol-modified prolactin secretion independently of action potentials and Ca2 + and blockade of outward potassium currents in GH3cells. Naunyn Schmiedebergs Arch Pharmacol 390(1):95\u2013104","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"3","key":"3220_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1530\/EJE-08-0289","volume":"159","author":"A Mueller","year":"2008","unstructured":"Mueller A, Gooren L (2008) Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones. Eur J Endocrinol 159(3):197\u2013202","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"3220_CR13","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1007\/s11060-013-1270-8","volume":"117","author":"ME Molitch","year":"2014","unstructured":"Molitch ME (2014) Management of medically refractory prolactinoma. J Neurooncol 117(3):421\u2013428","journal-title":"J Neurooncol"},{"issue":"6","key":"3220_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/j.1365-2265.1988.tb03849.x","volume":"28","author":"H Asscheman","year":"1988","unstructured":"Asscheman H, Gooren LJ, Assies J, Smits JP, de Slegte R (1988) Prolactin levels and pituitary enlargement in hormone-treated male-to-female transsexuals. Clin Endocrinol (Oxf) 28(6):583\u2013588","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"3220_CR15","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.clineuro.2011.10.035","volume":"114","author":"W Chao","year":"2012","unstructured":"Chao W, Zhi-qiang H, Ming C, Zhi W, Wei-guang Z, Lai-zang W et al (2012) Resveratrol inhibited GH3 cell growth and decreased prolactin level via estrogen receptors. Clin Neurol Neurosurg 114(3):241\u2013248","journal-title":"Clin Neurol Neurosurg"},{"key":"3220_CR16","first-page":"5364","volume":"22","author":"C Wang","year":"2018","unstructured":"Wang C, Xu J, Wen Y, Zhang D, Wang X, Chang L et al (2018) Fulvestrant inhibits the glycolysis of prolactinoma GH3 cells by downregulating IRE1 \/ XBP1 signaling pathway. Eur Rev Med Pharmacol Sci 22:5364\u20135370","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"12","key":"3220_CR17","doi-asserted-by":"publisher","first-page":"1694","DOI":"10.1016\/j.jocn.2011.06.013","volume":"18","author":"L Leng","year":"2011","unstructured":"Leng L, Zhang Y (2011) Effects of an estrogen receptor antagonist on proliferation, prolactin secretion and growth factor expression in the MMQ pituitary prolactinoma cell line. J Clin Neurosci 18(12):1694\u20131698","journal-title":"J Clin Neurosci"},{"issue":"22","key":"3220_CR18","first-page":"8037","volume":"63","author":"A Thiantanawat","year":"2003","unstructured":"Thiantanawat A, Long BJ, Brodie AM (2003) Signaling pathways of apoptosis activated by aromatase \u0131nhibitors and antiestrogens. Cancer Res 63(22):8037\u20138050","journal-title":"Cancer Res"},{"issue":"8","key":"3220_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0042398","volume":"7","author":"C Amaral","year":"2012","unstructured":"Amaral C, Borges M, Melo S, da Silva ET, Correia-da-Silva G, Teixeira N (2012) Apoptosis and autophagy in breast cancer cells following exemestane treatment. PLoS One 7(8):1\u201310","journal-title":"PLoS One"},{"key":"3220_CR20","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/j.steroids.2014.08.003","volume":"99","author":"RJ Santen","year":"2015","unstructured":"Santen RJ, Yue W, Wang JP (2015) Estrogen metabolites and breast cancer. Steroids 99:61\u20136","journal-title":"Steroids"},{"issue":"1","key":"3220_CR21","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1023\/A:1022176631922","volume":"5","author":"J Carretero","year":"2002","unstructured":"Carretero J, Burks DJ, V\u00e1zquez G, Rubio M, Hern\u00e1ndez E, Bodego P et al (2002) Expression of aromatase P450 is increased in spontaneous prolactinomas of aged rats. Pituitary 5(1):5\u201310","journal-title":"Pituitary"},{"issue":"3","key":"3220_CR22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1046\/j.1365-2265.1998.00390.x","volume":"48","author":"H Sasano","year":"1988","unstructured":"Sasano H, Takahashi K, Satoh F, Nagura H, Harada N (1988) Aromatase in the human central nervous system. Clin Endocrinol (Oxf) 48(3):325\u2013329","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"1","key":"3220_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s11102-007-0065-3","volume":"11","author":"P Kadioglu","year":"2008","unstructured":"Kadioglu P, Oral G, Sayitoglu M, Erensoy N, Senel B, Gazioglu N et al (2008) Aromatase cytochrome P450 enzyme expression in human pituitary. Pituitary 11(1):29\u201335","journal-title":"Pituitary"},{"issue":"3","key":"3220_CR24","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s11102-012-0436-2","volume":"16","author":"H Akinci","year":"2013","unstructured":"Akinci H, Kapucu A, Dar KA, Celik O, Tutunculer B, Sirin G et al (2013) Aromatase cytochrome P450 enzyme expression in prolactinomas and its relationship to tumor behavior. Pituitary 16(3):386\u2013392","journal-title":"Pituitary"},{"issue":"1","key":"3220_CR25","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1007\/s12020-014-0445-1","volume":"49","author":"A Selek","year":"2015","unstructured":"Selek A, Cetinarslan B, Gurbuz Y, Tarkun I, Canturk Z, Cabuk B (2015) Aromatase enzyme expression in acromegaly and its possible relationship with disease prognosis. Endocrine 49(1):250\u2013251","journal-title":"Endocrine"},{"key":"3220_CR26","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.wneu.2019.12.146","volume":"136","author":"F Strange","year":"2019","unstructured":"Strange F, Remonda L, Schu P, Fandino J, Berkmann S (2019) 10 years\u2019 experience of using low-field intraoperative MRI in transsphenoidal surgery for pituitary adenoma: results of the Swiss Pituitary Registry (SwissPit). World Neurosurg 136:284\u2013293","journal-title":"World Neurosurg"},{"issue":"28","key":"3220_CR27","doi-asserted-by":"publisher","first-page":"45874","DOI":"10.18632\/oncotarget.17437","volume":"8","author":"X Wang","year":"2017","unstructured":"Wang X, Du Q, Mao Z, Fan X, Hu B, Wang Z et al (2017) Combined treatment with artesunate and bromocriptine has synergistic anticancer effects in pituitary adenoma cell lines. Oncotarget 8(28):45874\u201345887","journal-title":"Oncotarget"},{"issue":"January","key":"3220_CR28","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1210\/jc.2018-02461","volume":"104","author":"D Zhang","year":"2019","unstructured":"Zhang D, Way JS, Zhang X, Sergey M, Bergsneider M, Wang MB et al (2019) Effect of everolimus in treatment of aggressive prolactin-secreting pituitary adenomas. J Clin Endocrinol Metab 104(January):1929\u20131936","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"3220_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1530\/EJE-19-0279","volume":"181","author":"EC Coopmans","year":"2019","unstructured":"Coopmans EC, Van Meyel SWF, Pieterman KJ, Van Ipenburg JA, Hofland LJ, Donga E et al (2019) Excellent response to pasireotide therapy in an aggressive and dopaminee-resistant prolactinoma. Eur J Endocrinol 181(2):21\u201327","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"3220_CR30","doi-asserted-by":"publisher","first-page":"4447","DOI":"10.1210\/jc.2002-020426","volume":"87","author":"MP Gillam","year":"2002","unstructured":"Gillam MP, Middler S, Freed DJ, Molitch ME (2002) The novel use of very high doses of cabergoline and a combination of testosterone and an aromatase \u0131nhibitor in the treatment of a giant prolactinoma. J Clin Endocrinol Metab 87(10):4447\u20134451","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"3220_CR31","doi-asserted-by":"publisher","first-page":"669","DOI":"10.4158\/EP10026.CR","volume":"16","author":"Z Heidari","year":"2010","unstructured":"Heidari Z, Hosseinpanah F, Shirazian N (2010) Achievement of fertility in an infertile man with resistant macroprolactinoma using high-dose bromocriptine and a combination of Human Chor\u0131on\u0131c Gonadotrop\u0131n and an aromatase inhibitor. Endocr Pract 16(4):669\u2013672","journal-title":"Endocr Pract"},{"issue":"7","key":"3220_CR32","doi-asserted-by":"publisher","first-page":"3115","DOI":"10.1177\/0300060519848916","volume":"47","author":"Y Su","year":"2019","unstructured":"Su Y, Du G, Shen H, Wang W, Bao J, Aierken A et al (2019) Increased expression of aromatase cytochrome P450 enzyme is associated with prolactinoma invasiveness in post-menopausal women. J Int Med Res 47(7):3115\u20133126","journal-title":"J Int Med Res"},{"issue":"11","key":"3220_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/ijms18112299","volume":"18","author":"MJ Garc\u00eda-Barrado","year":"2017","unstructured":"Garc\u00eda-Barrado MJ, Blanco EJ, Iglesias-Osma MC, Carretero-Hern\u00e1ndez M, Catalano-Iniesta L, Sanchez-Robledo V et al (2017) Relation among aromatase P450 and tumoral growth in human prolactinomas. Int J Mol Sci 18(11):1\u201316","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3220_CR34","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0101403","volume":"9","author":"MJ Garc\u00eda Barrado","year":"2014","unstructured":"Garc\u00eda Barrado MJ, Blanco EJ, Carretero Hern\u00e1ndez M, Iglesias Osma MC, Carretero M, Herrero JJ et al (2014) Local transformations of androgens into estradiol by aromatase P450 is involved in the regulation of prolactin and the proliferation of pituitary prolactin-positive cells. PLoS ONE 9(6):1\u20139","journal-title":"PLoS ONE"},{"issue":"4","key":"3220_CR35","doi-asserted-by":"publisher","first-page":"987","DOI":"10.3892\/ijmm.2014.1660","volume":"33","author":"X Zhang","year":"2014","unstructured":"Zhang X, Xu W, Su J, Chu M, Jin H, Li G et al (2014) The prosurvival role of autophagy in resveratrol-induced cytotoxicity in GH3 cells. Int J Mol Med 33(4):987\u2013993","journal-title":"Int J Mol Med"},{"issue":"10","key":"3220_CR36","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fendo.2019.00016","volume":"4","author":"DC Rodr\u00edguez-Lozano","year":"2019","unstructured":"Rodr\u00edguez-Lozano DC, Pi\u00f1a-Medina AG, Hansberg-Pastor V, Bello-Alvarez C, Camacho-Arroyo I (2019) Testosterone Promotes glioblastoma cell proliferation, migration, and \u0131nvasion through androgen receptor activation. Front Endocrinol (Lausanne) 4(10):16. https:\/\/doi.org\/10.3389\/fendo.2019.00016","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03220-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03220-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03220-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T11:20:09Z","timestamp":1679743209000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03220-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,20]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["3220"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03220-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2023,1,20]]},"assertion":[{"value":"29 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 January 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors. The study protocol was approved by the local ethics committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All authors have consent to participate in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have consent for publication of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"All authors have declared that no conflict of interest exists.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}