{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,25]],"date-time":"2025-07-25T10:53:09Z","timestamp":1753440789687,"version":"3.37.3"},"reference-count":65,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006734","name":"Instituto Nacional de Ci\u00eancia e Tecnologia de F\u00e1rmacos e Medicamentos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006734","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005667","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o do Estado de Santa Catarina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1007\/s12035-023-03244-8","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T12:22:32Z","timestamp":1675945352000},"page":"2954-2968","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Critical Pronociceptive Role of Family 2 Voltage-Gated Calcium Channels in a Novel Mouse Model of HIV-Associated Sensory Neuropathy"],"prefix":"10.1007","volume":"60","author":[{"given":"Debora Denardin","family":"L\u00fcckemeyer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arthur Silveira","family":"Prudente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"de Amorim Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Merian","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Tonello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio Jos\u00e9 Macedo","family":"Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Sant\u2019 Helena","family":"do Prado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lio Jos\u00e9","family":"de Castro J\u00fanior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Vinicius","family":"Gomez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Batista","family":"Calixto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9562-0602","authenticated-orcid":false,"given":"Juliano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"3244_CR1","unstructured":"WHO (2020) WHO: HIV\/Aids. Global Health Observatory (GHO) data. World Health Organization, 2020. https:\/\/www.who.int\/data\/gho\/data\/themes\/hiv-aids#:~:text=Global%20situation%20and%20trends%3A,at%20the%20end%20of%202021. 2020"},{"key":"3244_CR2","doi-asserted-by":"publisher","first-page":"2688","DOI":"10.1093\/brain\/awm195","volume":"130","author":"VC Wallace","year":"2007","unstructured":"Wallace VC, Blackbeard J, Segerdahl AR, Hasnie F, Pheby T, McMahon SB, Rice AS (2007) Characterization of rodent models of HIV-gp120 and anti-retroviral-associated neuropathic pain. Brain 130:2688\u201326702. https:\/\/doi.org\/10.1093\/brain\/awm195","journal-title":"Brain"},{"issue":"12","key":"3244_CR3","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1097\/01.NAJ.0000438867.67777.69","volume":"113","author":"JK Anastasi","year":"2013","unstructured":"Anastasi JK, Capili B, Chang M (2013) HIV peripheral neuropathy and foot care management: a review of assessment and relevant guidelines. Am J Nurs 113(12):34\u201340. https:\/\/doi.org\/10.1097\/01.NAJ.0000438867.67777.69","journal-title":"Am J Nurs"},{"issue":"4","key":"3244_CR4","doi-asserted-by":"publisher","first-page":"325","DOI":"10.2165\/00023210-200519040-00005","volume":"19","author":"S Verma","year":"2005","unstructured":"Verma S, Estanislao L, Simpson D (2005) HIV-associated neuropathic pain: epidemiology, pathophysiology and management. CNS Drugs 19(4):325\u2013334. https:\/\/doi.org\/10.2165\/00023210-200519040-00005","journal-title":"CNS Drugs"},{"key":"3244_CR5","first-page":"446","volume-title":"Massachusetts General Hospital handbook of pain management","author":"S Marshall","year":"2005","unstructured":"Marshall S, Coyle S, Rice AS (2005) Pain in human immunodeficiency virus and acquired immunodeficiency syndrome. In: Ballentyne JC (ed) Massachusetts General Hospital handbook of pain management. Lippincott Williams & Wilkins, Philadelphia, pp 446\u2013460"},{"key":"3244_CR6","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11940-017-0472-3","volume":"16","author":"A Aziz-Donnelly","year":"2017","unstructured":"Aziz-Donnelly A, Harrison TB (2017) Update of HIV-associated sensory neuropathies. Curr Treat Options Neurol 16:1\u201312. https:\/\/doi.org\/10.1007\/s11940-017-0472-3","journal-title":"Curr Treat Options Neurol"},{"issue":"5","key":"3244_CR7","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1093\/cid\/cir432","volume":"53","author":"SA Mehta","year":"2011","unstructured":"Mehta SA, Ahmed A, Laverty M, Holzman RS, Valentine F, Sivapalasingam S (2011) Sex differences in the incidence of peripheral neuropathy among Kenyans initiating antiretroviral therapy. Clin Infect Dis 53(5):490\u2013496. https:\/\/doi.org\/10.1093\/cid\/cir432","journal-title":"Clin Infect Dis"},{"key":"3244_CR8","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1097\/AJP.0000000000000186","volume":"31","author":"NP Katz","year":"2015","unstructured":"Katz NP, Mou J, Paillard FC, Turnbull B, Trudeau J, Stoker M (2015) Predictors of response in patients with postherpetic neuralgia and HIV-associated neuropathy treated with the 8% capsaicin patch (Qutenza). Clin J Pain 31:859\u2013866. https:\/\/doi.org\/10.1097\/AJP.0000000000000186","journal-title":"Clin J Pain"},{"issue":"5","key":"3244_CR9","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1212\/WNL.0000000000004136","volume":"89","author":"D Saylor","year":"2017","unstructured":"Saylor D, Nakigozi G, Nakasujja N, Robertson K, Gray RH, Wawer MJ, Sacktor N (2017) Peripheral neuropathy in HIV-infected and uninfected patients in Rakai. Uganda Neurology 89(5):485\u2013491. https:\/\/doi.org\/10.1212\/WNL.0000000000004136","journal-title":"Uganda Neurology"},{"key":"3244_CR10","doi-asserted-by":"publisher","first-page":"18719","DOI":"10.7448\/IAS.17.1.18719","volume":"17","author":"R Parker","year":"2014","unstructured":"Parker R, Stein DJ, Jelsma J (2014) Pain in people living with HIV\/AIDS: a systematic review. J Int AIDS Soc 17:18719. https:\/\/doi.org\/10.7448\/IAS.17.1.18719","journal-title":"J Int AIDS Soc"},{"key":"3244_CR11","doi-asserted-by":"publisher","first-page":"10299","DOI":"10.1523\/JNEUROSCI.3135-06.2006","volume":"26","author":"SC Keswani","year":"2006","unstructured":"Keswani SC, Jack C, Zhou C, H\u00f6ke A (2006) Establishment of a rodent model of HIV-associated sensory neuropathy. J Neurosci 26:10299\u201310304. https:\/\/doi.org\/10.1523\/JNEUROSCI.3135-06.2006","journal-title":"J Neurosci"},{"issue":"2","key":"3244_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/j.pain.2003.10.010","volume":"107","author":"EK Joseph","year":"2004","unstructured":"Joseph EK, Chen X, Khasar SG, Levine JD (2004) Novel mechanism of enhanced nociception in a model of AIDS therapy-induced painful peripheral neuropathy in the rat. Pain 107(2):147\u2013158. https:\/\/doi.org\/10.1016\/j.pain.2003.10.010","journal-title":"Pain"},{"issue":"14","key":"3244_CR13","doi-asserted-by":"publisher","first-page":"5027","DOI":"10.1523\/JNEUROSCI.21-14-05027.2001","volume":"21","author":"SB Oh","year":"2001","unstructured":"Oh SB, Tran PB, Gillard SE, Hurley RW, Hammond DL, Miller RJ (2001) Chemokines and glycoprotein120 produce pain hypersensitivity by directly exciting primary nociceptive neurons. J Neurosci 21(14):5027\u20135035. https:\/\/doi.org\/10.1523\/JNEUROSCI.21-14-05027.2001","journal-title":"J Neurosci"},{"issue":"6","key":"3244_CR14","first-page":"1119","volume":"45","author":"JL Werth","year":"1994","unstructured":"Werth JL, Zhou B, Nutter LM, Thayer SA (1994) 2\u2019,3\u2019-Dideoxycytidine alters calcium buffering in cultured dorsal root ganglion neurons. Mol Pharmacol 45(6):1119\u20131124","journal-title":"Mol Pharmacol"},{"key":"3244_CR15","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ceca.2018.07.009","volume":"74","author":"Y Mei","year":"2018","unstructured":"Mei Y, Barrett JE, Hu H (2018) Calcium release-activated calcium channels and pain. Cell Calcium 74:180\u2013185. https:\/\/doi.org\/10.1016\/j.ceca.2018.07.009","journal-title":"Cell Calcium"},{"issue":"12","key":"3244_CR16","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1111\/bph.13789","volume":"175","author":"R Patel","year":"2018","unstructured":"Patel R, Montagut-Bordas C, Dickenson AH (2018) Calcium channel modulation as a target in chronic pain control. Br J Pharmacol 175(12):2173\u20132184. https:\/\/doi.org\/10.1111\/bph.13789","journal-title":"Br J Pharmacol"},{"issue":"13","key":"3244_CR17","doi-asserted-by":"publisher","first-page":"4536","DOI":"10.1523\/JNEUROSCI.5161-09.2010","volume":"30","author":"YQ Cao","year":"2010","unstructured":"Cao YQ, Tsien RW (2010) Different relationship of N- and P\/Q-type Ca2+ channels to channel-interacting slots in controlling neurotransmission at cultured hippocampal synapses. J Neurosci 30(13):4536\u20134546. https:\/\/doi.org\/10.1523\/JNEUROSCI.5161-09.2010","journal-title":"J Neurosci"},{"key":"3244_CR18","doi-asserted-by":"publisher","first-page":"5369","DOI":"10.1113\/JP272262","volume":"594","author":"AC Dolphin","year":"2016","unstructured":"Dolphin AC (2016) Voltage-gated calcium channels and their auxiliary subunits: physiology and pathophysiology and pharmacology. J Physiol 594:5369\u20135390. https:\/\/doi.org\/10.1113\/JP272262","journal-title":"J Physiol"},{"issue":"2","key":"3244_CR19","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1523\/JNEUROSCI.19-02-00726.1999","volume":"19","author":"LG Wu","year":"1999","unstructured":"Wu LG, Westenbroek RE, Borst JG, Catterall WA, Sakmann B (1999) Calcium channel types with distinct presynaptic localization couple differentially to transmitter release in single calyx-type synapses. J Neurosci 19(2):726\u2013736. https:\/\/doi.org\/10.1523\/JNEUROSCI.19-02-00726.1999","journal-title":"J Neurosci"},{"issue":"1","key":"3244_CR20","doi-asserted-by":"publisher","first-page":"NS20160003","DOI":"10.1042\/NS20160003","volume":"1","author":"N Weiss","year":"2017","unstructured":"Weiss N, Zamponi GW (2017) Trafficking of neuronal calcium channels. Neuronal Signal 1(1):NS20160003. https:\/\/doi.org\/10.1042\/NS20160003","journal-title":"Neuronal Signal"},{"issue":"9725","key":"3244_CR21","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1016\/S0140-6736(10)60354-6","volume":"375","author":"A Schmidtko","year":"2010","unstructured":"Schmidtko A, Lotsch J, Freynhagen R, Geisslinger G (2010) Ziconotide for treatment of severe chronic pain. Lancet 375(9725):1569\u20131577. https:\/\/doi.org\/10.1016\/S0140-6736(10)60354-6","journal-title":"Lancet"},{"issue":"2","key":"3244_CR22","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","volume":"16","author":"M Zimmermann","year":"1983","unstructured":"Zimmermann M (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16(2):109\u2013110. https:\/\/doi.org\/10.1016\/0304-3959(83)90201-4","journal-title":"Pain"},{"key":"3244_CR23","doi-asserted-by":"crossref","unstructured":"Armitage P, Berry G, Matthews JMS (2001) Statistical Methods in medical research. 4th edn.,","DOI":"10.1002\/9780470773666"},{"issue":"2\u20133","key":"3244_CR24","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/0014-2999(80)90515-4","volume":"67","author":"JL Hylden","year":"1980","unstructured":"Hylden JL, Wilcox GL (1980) Intrathecal morphine in mice: a new technique. Eur J Pharmacol 67(2\u20133):313\u2013316. https:\/\/doi.org\/10.1016\/0014-2999(80)90515-4","journal-title":"Eur J Pharmacol"},{"issue":"6","key":"3244_CR25","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1002\/ana.24139","volume":"75","author":"S-B Yuan","year":"2014","unstructured":"Yuan S-B, Shi Y, Chen J, Zhou X, Li G, Gelman BB, Lisinicchia JG, Carlton SM, Ferguson MR, Tan A, Sarna SK, Tang S-J (2014) Gp120 in the pathogenesis of human immunodeficiency virus\u2013associated pain. Ann Neurol 75(6):837\u2013850. https:\/\/doi.org\/10.1002\/ana.24139","journal-title":"Ann Neurol"},{"issue":"4","key":"3244_CR26","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.pain.2012.12.023","volume":"154","author":"W Huang","year":"2013","unstructured":"Huang W, Calvo M, Karu K, Olausen HR, Bathgate G, Okuse K, Bennett DL, Rice AS (2013) A clinically relevant rodent model of the HIV antiretroviral drug stavudine induced painful peripheral neuropathy. Pain 154(4):560\u2013575. https:\/\/doi.org\/10.1016\/j.pain.2012.12.023","journal-title":"Pain"},{"issue":"1","key":"3244_CR27","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","volume":"53","author":"SR Chaplan","year":"1994","unstructured":"Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53(1):55\u201363. https:\/\/doi.org\/10.1016\/0165-0270(94)90144-9","journal-title":"J Neurosci Methods"},{"issue":"4","key":"3244_CR28","doi-asserted-by":"publisher","first-page":"e2198","DOI":"10.1371\/journal.pntd.0002198","volume":"7","author":"C Gewehr","year":"2013","unstructured":"Gewehr C, Oliveira SM, Rossato MF, Trevisan G, Dalmolin GD, Rigo FK, de Castro Junior CJ, Cordeiro MN, Ferreira J, Gomez MV (2013) Mechanisms involved in the nociception triggered by the venom of the armed spider Phoneutria nigriventer. PLoS Negl Trop Dis 7(4):e2198. https:\/\/doi.org\/10.1371\/journal.pntd.0002198","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"3244_CR29","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/nm.4262","volume":"23","author":"G Corder","year":"2017","unstructured":"Corder G, Tawfik VL, Wang D, Sypek EI, Low SA, Dickinson JR, Sotoudeh C, Clark JD, Barres BA, Bohlen CJ, Scherrer G (2017) Loss of \u03bc opioid receptor signaling in nociceptors, but not microglia, abrogates morphine tolerance without disrupting analgesia. Nat Med 23(2):164\u2013173. https:\/\/doi.org\/10.1038\/nm.4262","journal-title":"Nat Med"},{"issue":"25","key":"3244_CR30","doi-asserted-by":"publisher","first-page":"10559","DOI":"10.1523\/JNEUROSCI.4629-12.2013","volume":"33","author":"TB Tarr","year":"2013","unstructured":"Tarr TB, Malick W, Liang M, Valdomir G, Frasso M, Lacomis D, Reddel SW, Garcia-Ocano A, Wipf P, Meriney SD (2013) Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome. J Neurosci 33(25):10559\u201310567. https:\/\/doi.org\/10.1523\/JNEUROSCI.4629-12.2013","journal-title":"J Neurosci"},{"issue":"6","key":"3244_CR31","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.jpain.2009.09.016","volume":"11","author":"MF Rossato","year":"2010","unstructured":"Rossato MF, Velloso NA, de Oliveira Ferreira AP, de Mello CF, Ferreira J (2010) Spinal levels of nonprotein thiols are related to nociception in mice. J Pain 11(6):545\u2013554. https:\/\/doi.org\/10.1016\/j.jpain.2009.09.016","journal-title":"J Pain"},{"issue":"8","key":"3244_CR32","doi-asserted-by":"publisher","first-page":"4882","DOI":"10.1523\/JNEUROSCI.14-08-04882.1994","volume":"14","author":"AB Malmberg","year":"1994","unstructured":"Malmberg AB, Yaksh TL (1994) Voltage-sensitive calcium channels in spinal nociceptive processing: blockade of N- and P-type channels inhibits formalin-induced nociception. J Neurosci 14(8):4882\u20134890. https:\/\/doi.org\/10.1523\/JNEUROSCI.14-08-04882.1994","journal-title":"J Neurosci"},{"key":"3244_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuropharm.2013.06.018","volume":"75","author":"T Terashima","year":"2013","unstructured":"Terashima T, Xu Q, Yamaguchi S, Yaksh T (2013) Intrathecal P\/Q- and R-type calcium channel blockade of spinal substance P release and c-Fos expression. Neuropharmacology 75:1\u20138. https:\/\/doi.org\/10.1016\/j.neuropharm.2013.06.018","journal-title":"Neuropharmacology"},{"issue":"9","key":"3244_CR34","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1097\/j.pain.0000000000000953","volume":"158","author":"KA Schappacher","year":"2017","unstructured":"Schappacher KA, Styczynski L, Baccei ML (2017) Early life vincristine exposure evokes mechanical pain hypersensitivity in the developing rat. Pain 158(9):1647\u20131655. https:\/\/doi.org\/10.1097\/j.pain.0000000000000953","journal-title":"Pain"},{"issue":"25\u201326","key":"3244_CR35","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1016\/j.lfs.2011.03.017","volume":"88","author":"CR Silva","year":"2011","unstructured":"Silva CR, Oliveira SM, Rossato MF, Dalmolin GD, Guerra GP, da Silveira PA, Cabrini DA, Otuki MF, Andre E, Ferreira J (2011) The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice. Life Sci 88(25\u201326):1077\u20131087. https:\/\/doi.org\/10.1016\/j.lfs.2011.03.017","journal-title":"Life Sci"},{"issue":"4","key":"3244_CR36","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta c(t)) method. Methods 25(4):402\u2013408. https:\/\/doi.org\/10.1006\/meth.2001.1262","journal-title":"Methods"},{"issue":"9","key":"3244_CR37","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1097\/j.pain.0000000000000978","volume":"158","author":"MP Klinck","year":"2017","unstructured":"Klinck MP, Mogil JS, Moreau M, Lascelles BDX, Flecknell PA, Poitte T, Troncy E (2017) Translational pain assessment: could natural animal models be the missing link? Pain 158(9):1633\u20131646. https:\/\/doi.org\/10.1097\/j.pain.0000000000000978","journal-title":"Pain"},{"issue":"5","key":"3244_CR38","doi-asserted-by":"publisher","first-page":"465","DOI":"10.2217\/fvl.14.28","volume":"9","author":"TH Burdo","year":"2014","unstructured":"Burdo TH, Miller AD (2014) Animal models of HIV peripheral neuropathy. Future Virol 9(5):465\u2013474. https:\/\/doi.org\/10.2217\/fvl.14.28","journal-title":"Future Virol"},{"issue":"9","key":"3244_CR39","doi-asserted-by":"publisher","first-page":"1846","DOI":"10.1016\/j.pain.2014.06.014","volume":"155","author":"TJC Phillips","year":"2014","unstructured":"Phillips TJC, Brown M, Ramirez JD, Perkins J, Woldeamanuel YW, Williams ACC, Orengo C, Bennett DLH, Bodi I, Cox S, Maier C, Krumova EK, Rice ASC (2014) Sensory, psychological, and metabolic dysfunction in HIV-associated peripheral neuropathy: a cross-sectional deep profiling study. Pain 155(9):1846\u20131860. https:\/\/doi.org\/10.1016\/j.pain.2014.06.014","journal-title":"Pain"},{"key":"3244_CR40","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3389\/fnbeh.2010.00165","volume":"4","author":"P Jirkof","year":"2010","unstructured":"Jirkof P, Cesarovic N, Rettich A, Nicholls F, Seifert B, Arras M (2010) Burrowing behavior as an indicator of post-laparotomy pain in mice. Front Behav Neurosci 4:165. https:\/\/doi.org\/10.3389\/fnbeh.2010.00165","journal-title":"Front Behav Neurosci"},{"issue":"1","key":"3244_CR41","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1212\/wnl.58.1.115","volume":"58","author":"M Polydefkis","year":"2002","unstructured":"Polydefkis M, Yiannoutsos CT, Cohen BA, Hollander H, Schifitto G, Clifford DB, Simpson DM, Katzenstein D, Shriver S, Hauer P, Brown A, Haidich AB, Moo L, McArthur JC (2002) Reduced intraepidermal nerve fiber density in HIV-associated sensory neuropathy. Neurology 58(1):115\u2013119. https:\/\/doi.org\/10.1212\/wnl.58.1.115","journal-title":"Neurology"},{"issue":"7","key":"3244_CR42","doi-asserted-by":"publisher","first-page":"1912","DOI":"10.1016\/j.ajpath.2015.03.007","volume":"185","author":"JR Lakritz","year":"2015","unstructured":"Lakritz JR, Bodair A, Shah N, O\u2019Donnell R, Polydefkis MJ, Miller AD, Burdo TH (2015) Monocyte traffic, dorsal root ganglion histopathology, and loss of intraepidermal nerve fiber density in SIV peripheral neuropathy. Am J Pathol 185(7):1912\u20131923. https:\/\/doi.org\/10.1016\/j.ajpath.2015.03.007","journal-title":"Am J Pathol"},{"issue":"3","key":"3244_CR43","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.neuint.2006.01.022","volume":"49","author":"WF Chiou","year":"2006","unstructured":"Chiou WF (2006) Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits (alpha 1A-alpha 1D) in human SK-N-SH neuroblastoma. Neurochem Int 49(3):256\u2013261. https:\/\/doi.org\/10.1016\/j.neuint.2006.01.022","journal-title":"Neurochem Int"},{"issue":"Pt 11","key":"3244_CR44","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1113\/jphysiol.2009.172312","volume":"587","author":"MA Motagally","year":"2009","unstructured":"Motagally MA, Lukewich MK, Chisholm SP, Neshat S, Lomax AE (2009) Tumour necrosis factor alpha activates nuclear factor kappaB signalling to reduce N-type voltage-gated Ca2+ current in postganglionic sympathetic neurons. J Physiol 587(Pt 11):2623\u20132634. https:\/\/doi.org\/10.1113\/jphysiol.2009.172312","journal-title":"J Physiol"},{"issue":"7","key":"3244_CR45","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.7150\/thno.19500","volume":"7","author":"JJ Lin","year":"2017","unstructured":"Lin JJ, Lin Y, Zhao TZ, Zhang CK, Zhang T, Chen XL, Ding JQ, Chang T, Zhang Z, Sun C, Zhao DD, Zhu JL, Li ZY, Li JL (2017) Melatonin suppresses neuropathic pain via MT2-dependent and -independent pathways in dorsal root ganglia neurons of mice. Theranostics 7(7):2015\u20132032. https:\/\/doi.org\/10.7150\/thno.19500","journal-title":"Theranostics"},{"key":"3244_CR46","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ynpai.2018.04.001","volume":"4","author":"S Uttam","year":"2018","unstructured":"Uttam S, Wong C, Amorim IS, Jafarnejad SM, Tansley SN, Yang J, Prager-Khoutorsky M, Mogil JS, Gkogkas CG, Khoutorsky A (2018) Translational profiling of dorsal root ganglia and spinal cord in a mouse model of neuropathic pain. Neurobiol Pain 4:35\u201344. https:\/\/doi.org\/10.1016\/j.ynpai.2018.04.001","journal-title":"Neurobiol Pain"},{"issue":"10","key":"3244_CR47","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/nn.2643","volume":"13","author":"A Andrade","year":"2010","unstructured":"Andrade A, Denome S, Jiang YQ, Marangoudakis S, Lipscombe D (2010) Opioid inhibition of N-type Ca2+ channels and spinal analgesia couple to alternative splicing. Nat Neurosci 13(10):1249\u20131256. https:\/\/doi.org\/10.1038\/nn.2643","journal-title":"Nat Neurosci"},{"issue":"1","key":"3244_CR48","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/s0896-6273(03)00801-8","volume":"41","author":"TJ Bell","year":"2004","unstructured":"Bell TJ, Thaler C, Castiglioni AJ, Helton TD, Lipscombe D (2004) Cell-specific alternative splicing increases calcium channel current density in the pain pathway. Neuron 41(1):127\u2013138. https:\/\/doi.org\/10.1016\/s0896-6273(03)00801-8","journal-title":"Neuron"},{"key":"3244_CR49","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.bbi.2018.04.016","volume":"71","author":"J Yang","year":"2018","unstructured":"Yang J, Xie MX, Hu L, Wang XF, Mai JZ, Li YY, Wu N, Zhang C, Li J, Pang RP, Liu XG (2018) Upregulation of N-type calcium channels in the soma of uninjured dorsal root ganglion neurons contributes to neuropathic pain by increasing neuronal excitability following peripheral nerve injury. Brain Behav Immun 71:52\u201365. https:\/\/doi.org\/10.1016\/j.bbi.2018.04.016","journal-title":"Brain Behav Immun"},{"key":"3244_CR50","doi-asserted-by":"publisher","first-page":"147438","DOI":"10.1016\/j.brainres.2021.147438","volume":"1764","author":"MA Ferreira","year":"2021","unstructured":"Ferreira MA, Luckemeyer DD, Macedo-Junior SJ, Schran RG, Silva AM, Prudente AS, Tonello R, Ferreira J (2021) Sex-dependent Cav2.3 channel contribution to the secondary hyperalgesia in a mice model of central sensitization. Brain Res 1764:147438. https:\/\/doi.org\/10.1016\/j.brainres.2021.147438","journal-title":"Brain Res"},{"issue":"21","key":"3244_CR51","doi-asserted-by":"publisher","first-page":"1995","DOI":"10.1016\/j.lfs.2006.06.039","volume":"79","author":"M Umeda","year":"2006","unstructured":"Umeda M, Ohkubo T, Ono J, Fukuizumi T, Kitamura K (2006) Molecular and immunohistochemical studies in expression of voltage-dependent Ca2+ channels in dorsal root ganglia from streptozotocin-induced diabetic mice. Life Sci 79(21):1995\u20132000. https:\/\/doi.org\/10.1016\/j.lfs.2006.06.039","journal-title":"Life Sci"},{"key":"3244_CR52","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1001\/jama.291.1.63","volume":"291","author":"PS Staats","year":"2004","unstructured":"Staats PS, Yearwood CSG, Presley RW, Wallace MS, Byas-Smith M, Fisher R, Bryce DA, Mangieri EA, Luther RR, Mayo M, McGuire D, Ellis D (2004) Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA 291:63\u201370. https:\/\/doi.org\/10.1001\/jama.291.1.63","journal-title":"JAMA"},{"issue":"1","key":"3244_CR53","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.pain.2008.07.014","volume":"140","author":"AH Souza","year":"2008","unstructured":"Souza AH, Ferreira J, Cordeiro MN, Vieira LB, De Castro CJ, Trevisan G, Reis H, Souza IA, Richardson M, Prado MA, Prado VF, Gomez MV (2008) Analgesic effect in rodents of native and recombinant Ph alpha 1beta toxin, a high-voltage-activated calcium channel blocker isolated from armed spider venom. Pain 140(1):115\u2013126. https:\/\/doi.org\/10.1016\/j.pain.2008.07.014","journal-title":"Pain"},{"issue":"3","key":"3244_CR54","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1124\/jpet.105.087023","volume":"314","author":"LB Vieira","year":"2005","unstructured":"Vieira LB, Kushmerick C, Hildebrand ME, Garcia E, Stea A, Cordeiro MN, Richardson M, Gomez MV, Snutch TP (2005) Inhibition of high voltage-activated calcium channels by spider toxin PnTx3-6. J Pharmacol Exp Ther 314(3):1370\u20131377. https:\/\/doi.org\/10.1124\/jpet.105.087023","journal-title":"J Pharmacol Exp Ther"},{"key":"3244_CR55","doi-asserted-by":"publisher","unstructured":"Mohammed SI, Eldabe S, Simpson KH, Brookes M, Madzinga G, Gulve A, Baranidharan G, Radford H, Crowther T, Buchser E, Perruchoud C, Batterham AM (2013) Bolus intrathecal injection of ziconotide (Prialt(R)) to evaluate the option of continuous administration via an implanted intrathecal drug delivery (ITDD) system: a pilot study. Neuromodulation 16 (6):576\u2013581; discussion 582. https:\/\/doi.org\/10.1111\/ner.12003","DOI":"10.1111\/ner.12003"},{"issue":"10","key":"3244_CR56","doi-asserted-by":"publisher","first-page":"2224","DOI":"10.1016\/j.pain.2011.04.015","volume":"152","author":"GD Dalmolin","year":"2011","unstructured":"Dalmolin GD, Silva CR, Rigo FK, Gomes GM, Cordeiro Mdo N, Richardson M, Silva MA, Prado MA, Gomez MV, Ferreira J (2011) Antinociceptive effect of Brazilian armed spider venom toxin Tx3-3 in animal models of neuropathic pain. Pain 152(10):2224\u20132232. https:\/\/doi.org\/10.1016\/j.pain.2011.04.015","journal-title":"Pain"},{"issue":"5","key":"3244_CR57","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/ejp.585","volume":"19","author":"E Chang","year":"2015","unstructured":"Chang E, Chen X, Kim M, Gong N, Bhatia S, Luo ZD (2015) Differential effects of voltage-gated calcium channel blockers on calcium channel alpha-2-delta-1 subunit protein-mediated nociception. Eur J Pain 19(5):639\u2013648. https:\/\/doi.org\/10.1002\/ejp.585","journal-title":"Eur J Pain"},{"issue":"12","key":"3244_CR58","doi-asserted-by":"publisher","first-page":"3561","DOI":"10.1111\/j.1460-9568.2007.05605.x","volume":"25","author":"EA Matthews","year":"2007","unstructured":"Matthews EA, Bee LA, Stephens GJ, Dickenson AH (2007) The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Eur J Neurosci 25(12):3561\u20133569. https:\/\/doi.org\/10.1111\/j.1460-9568.2007.05605.x","journal-title":"Eur J Neurosci"},{"issue":"4","key":"3244_CR59","doi-asserted-by":"publisher","first-page":"e610","DOI":"10.1097\/PR9.0000000000000610","volume":"2","author":"GD Dalmolin","year":"2017","unstructured":"Dalmolin GD, Bannister K, Goncalves L, Sikandar S, Patel R, Cordeiro MDN, Gomez MV, Ferreira J, Dickenson AH (2017) Effect of the spider toxin Tx3\u20133 on spinal processing of sensory information in naive and neuropathic rats: an in vivo electrophysiological study. Pain Rep 2(4):e610. https:\/\/doi.org\/10.1097\/PR9.0000000000000610","journal-title":"Pain Rep"},{"issue":"2","key":"3244_CR60","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1097\/AJP.0b013e31824ce65c","volume":"29","author":"I Gilron","year":"2013","unstructured":"Gilron I, Tu D, Holden RR (2013) Sensory and affective pain descriptors respond differentially to pharmacological interventions in neuropathic conditions. Clin J Pain 29(2):124\u2013131. https:\/\/doi.org\/10.1097\/AJP.0b013e31824ce65c","journal-title":"Clin J Pain"},{"key":"3244_CR61","doi-asserted-by":"publisher","unstructured":"Dolphin AC (2018) Voltage-gated calcium channel alpha 2delta subunits: an assessment of proposed novel roles. F1000Res 7. https:\/\/doi.org\/10.12688\/f1000research.16104.1","DOI":"10.12688\/f1000research.16104.1"},{"issue":"3","key":"3244_CR62","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1124\/jpet.102.041574","volume":"303","author":"ZD Luo","year":"2002","unstructured":"Luo ZD, Calcutt NA, Higuera ES, Valder CR, Song YH, Svensson CI, Myers RR (2002) Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin. J Pharmacol Exp Ther 303(3):1199\u20131205. https:\/\/doi.org\/10.1124\/jpet.102.041574","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"3244_CR63","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1016\/j.neuroscience.2006.09.044","volume":"144","author":"W Xiao","year":"2007","unstructured":"Xiao W, Boroujerdi A, Bennett GJ, Luo ZD (2007) Chemotherapy-evoked painful peripheral neuropathy: analgesic effects of gabapentin and effects on expression of the alpha-2-delta type-1 calcium channel subunit. Neuroscience 144(2):714\u2013720. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.09.044","journal-title":"Neuroscience"},{"issue":"5","key":"3244_CR64","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1212\/WNL.0b013e3181ccc6ef","volume":"74","author":"DM Simpson","year":"2010","unstructured":"Simpson DM, Schifitto G, Clifford DB, Murphy TK, Durso-De Cruz E, Glue P, Whalen E, Emir B, Scott GN, Freeman R, Group HIVNS (2010) Pregabalin for painful HIV neuropathy: a randomized, double-blind, placebo-controlled trial. Neurology 74(5):413\u2013420. https:\/\/doi.org\/10.1212\/WNL.0b013e3181ccc6ef","journal-title":"Neurology"},{"issue":"10","key":"3244_CR65","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1016\/j.pain.2014.05.027","volume":"155","author":"DM Simpson","year":"2014","unstructured":"Simpson DM, Rice AS, Emir B, Landen J, Semel D, Chew ML, Sporn J (2014) A randomized, double-blind, placebo-controlled trial and open-label extension study to evaluate the efficacy and safety of pregabalin in the treatment of neuropathic pain associated with human immunodeficiency virus neuropathy. Pain 155(10):1943\u20131954. https:\/\/doi.org\/10.1016\/j.pain.2014.05.027","journal-title":"Pain"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03244-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03244-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03244-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,25]],"date-time":"2023-03-25T11:24:03Z","timestamp":1679743443000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03244-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["3244"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03244-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"11 July 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 January 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All experimental procedures were conducted in accordance with the Ethics Committee of Universidade Federal de Santa Catarina.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}