{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:15:30Z","timestamp":1791396930781,"version":"4.3.3"},"reference-count":88,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:00:00Z","timestamp":1682553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["grant numbers 81571275"],"award-info":[{"award-number":["grant numbers 81571275"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["11932003"],"award-info":[{"award-number":["11932003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"the National Institutes of Health","doi-asserted-by":"crossref","award":["grant numbers NS065957"],"award-info":[{"award-number":["grant numbers NS065957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"the National Institutes of Health","doi-asserted-by":"crossref","award":["NS103740"],"award-info":[{"award-number":["NS103740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"the National Institutes of Health","doi-asserted-by":"crossref","award":["NS127846"],"award-info":[{"award-number":["NS127846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1007\/s12035-023-03351-6","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T09:02:53Z","timestamp":1682586173000},"page":"4396-4417","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Aberrant adenosine signaling in patients with focal cortical dysplasia"],"prefix":"10.1007","volume":"60","author":[{"given":"Mengyi","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiongfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongyang","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghua","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangru","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuguang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlev","family":"Boison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9674-6549","authenticated-orcid":false,"given":"Guoming","family":"Luan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0883-4988","authenticated-orcid":false,"given":"Tianfu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,4,27]]},"reference":[{"issue":"3","key":"3351_CR1","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-0035-1552617","volume":"35","author":"PB Crino","year":"2015","unstructured":"Crino PB (2015) Focal Cortical Dysplasia. Seminars Neurol 35(3):201\u20138. https:\/\/doi.org\/10.1055\/s-0035-1552617","journal-title":"Seminars Neurol"},{"issue":"1","key":"3351_CR2","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1528-1167.2010.02777.x","volume":"52","author":"I Bl\u00fcmcke","year":"2011","unstructured":"Bl\u00fcmcke I, Thom M, Aronica E et al (2011) The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission. Epilepsia. 52(1):158\u201374. https:\/\/doi.org\/10.1111\/j.1528-1167.2010.02777.x","journal-title":"Epilepsia."},{"issue":"3","key":"3351_CR3","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1684\/epd.2010.0327","volume":"12","author":"L Tassi","year":"2010","unstructured":"Tassi L, Garbelli R, Colombo N et al (2010) Type I focal cortical dysplasia: surgical outcome is related to histopathology. Epileptic Dis\u202f: Int Epilepsy J Videotape. 12(3):181\u201391. https:\/\/doi.org\/10.1684\/epd.2010.0327","journal-title":"Epileptic Dis : Int Epilepsy J Videotape."},{"issue":"11","key":"3351_CR4","doi-asserted-by":"publisher","first-page":"1669","DOI":"10.1111\/epi.13200","volume":"56","author":"R Guerrini","year":"2015","unstructured":"Guerrini R, Duchowny M, Jayakar P et al (2015) Diagnostic methods and treatment options for focal cortical dysplasia. Epilepsia. 56(11):1669\u201386. https:\/\/doi.org\/10.1111\/epi.13200","journal-title":"Epilepsia."},{"issue":"Pt 8","key":"3351_CR5","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1093\/brain\/awf175","volume":"125","author":"L Tassi","year":"2002","unstructured":"Tassi L, Colombo N, Garbelli R et al (2002) Focal cortical dysplasia: neuropathological subtypes, EEG, neuroimaging and surgical outcome. Brain\u202f: J Neurol 125(Pt 8):1719\u201332. https:\/\/doi.org\/10.1093\/brain\/awf175","journal-title":"Brain : J Neurol"},{"issue":"4","key":"3351_CR6","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1038\/nm.3824","volume":"21","author":"JS Lim","year":"2015","unstructured":"Lim JS, Kim WI, Kang HC et al (2015) Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy. Nat Med 21(4):395\u2013400. https:\/\/doi.org\/10.1038\/nm.3824","journal-title":"Nat Med"},{"issue":"3","key":"3351_CR7","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/ana.24444","volume":"78","author":"M Nakashima","year":"2015","unstructured":"Nakashima M, Saitsu H, Takei N et al (2015) Somatic Mutations in the MTOR gene cause focal cortical dysplasia type IIb. Ann Neurol 78(3):375\u201386. https:\/\/doi.org\/10.1002\/ana.24444","journal-title":"Ann Neurol"},{"issue":"5","key":"3351_CR8","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.it.2009.02.002","volume":"30","author":"T Weichhart","year":"2009","unstructured":"Weichhart T, S\u00e4emann MD (2009) The multiple facets of mTOR in immunity. Trends Immunol 30(5):218\u201326. https:\/\/doi.org\/10.1016\/j.it.2009.02.002","journal-title":"Trends Immunol"},{"issue":"2","key":"3351_CR9","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/s0969-9961(03)00127-x","volume":"14","author":"M Maldonado","year":"2003","unstructured":"Maldonado M, Baybis M, Newman D et al (2003) Expression of ICAM-1, TNF-alpha, NF kappa B, and MAP kinase in tubers of the tuberous sclerosis complex. Neurobiol Dis 14(2):279\u201390. https:\/\/doi.org\/10.1016\/s0969-9961(03)00127-x","journal-title":"Neurobiol Dis"},{"issue":"1\u20132","key":"3351_CR10","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.jneuroim.2006.01.002","volume":"173","author":"K Boer","year":"2006","unstructured":"Boer K, Spliet WG, van Rijen PC, Redeker S, Troost D, Aronica E (2006) Evidence of activated microglia in focal cortical dysplasia. J Neuroimmunol 173(1\u20132):188\u201395. https:\/\/doi.org\/10.1016\/j.jneuroim.2006.01.002","journal-title":"J Neuroimmunol"},{"issue":"2","key":"3351_CR11","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.yebeh.2006.05.012","volume":"9","author":"C Cepeda","year":"2006","unstructured":"Cepeda C, Andr\u00e9 VM, Levine MS et al (2006) Epileptogenesis in pediatric cortical dysplasia: the dysmature cerebral developmental hypothesis. Epilepsy Behavior\u202f: E&B. 9(2):219\u201335. https:\/\/doi.org\/10.1016\/j.yebeh.2006.05.012","journal-title":"Epilepsy Behavior : E&B."},{"issue":"Pt 8","key":"3351_CR12","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/brain\/124.8.1555","volume":"124","author":"A Hammers","year":"2001","unstructured":"Hammers A, Koepp MJ, Richardson MP et al (2001) Central benzodiazepine receptors in malformations of cortical development: A quantitative study. Brain\u202f: J Neurol 124(Pt 8):1555\u201365. https:\/\/doi.org\/10.1093\/brain\/124.8.1555","journal-title":"Brain : J Neurol"},{"issue":"2","key":"3351_CR13","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1097\/nen.0000000000000156","volume":"74","author":"G Luan","year":"2015","unstructured":"Luan G, Gao Q, Zhai F et al (2015) Adenosine kinase expression in cortical dysplasia with balloon cells: analysis of developmental lineage of cell types. J Neuropathol Exp Neurol 74(2):132\u201347. https:\/\/doi.org\/10.1097\/nen.0000000000000156","journal-title":"J Neuropathol Exp Neurol"},{"issue":"2","key":"3351_CR14","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1172\/jci33737","volume":"118","author":"T Li","year":"2008","unstructured":"Li T, Ren G, Lusardi T et al (2008) Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice. J Clin Investig 118(2):571\u201382. https:\/\/doi.org\/10.1172\/jci33737","journal-title":"J Clin Investig"},{"issue":"7","key":"3351_CR15","doi-asserted-by":"publisher","first-page":"2679","DOI":"10.1172\/jci57813","volume":"121","author":"SA Masino","year":"2011","unstructured":"Masino SA, Li T, Theofilas P et al (2011) A ketogenic diet suppresses seizures in mice through adenosine A1 receptors. J Clin Investig 121(7):2679\u201383. https:\/\/doi.org\/10.1172\/jci57813","journal-title":"J Clin Investig"},{"issue":"4","key":"3351_CR16","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1017\/s1740925x0800015x","volume":"3","author":"T Li","year":"2007","unstructured":"Li T, Quan Lan J, Fredholm BB, Simon RP, Boison D (2007) Adenosine dysfunction in astrogliosis: cause for seizure generation? Neuron glia Biol 3(4):353\u201366. https:\/\/doi.org\/10.1017\/s1740925x0800015x","journal-title":"Neuron glia Biol"},{"issue":"1\u20132","key":"3351_CR17","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.eplepsyres.2012.02.012","volume":"100","author":"C Moschovos","year":"2012","unstructured":"Moschovos C, Kostopoulos G, Papatheodoropoulos C (2012) Endogenous adenosine induces NMDA receptor-independent persistent epileptiform discharges in dorsal and ventral hippocampus via activation of A2 receptors. Epilepsy Res 100(1\u20132):157\u201367. https:\/\/doi.org\/10.1016\/j.eplepsyres.2012.02.012","journal-title":"Epilepsy Res"},{"key":"3351_CR18","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.neuropharm.2015.08.046","volume":"104","author":"D Boison","year":"2016","unstructured":"Boison D (2016) Adenosinergic signaling in epilepsy. Neuropharmacology. 104:131\u20139. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.08.046","journal-title":"Neuropharmacology."},{"issue":"4","key":"3351_CR19","doi-asserted-by":"publisher","first-page":"344","DOI":"10.2174\/1389450122666210928145258","volume":"23","author":"M Guo","year":"2022","unstructured":"Guo M, Li T (2022) Adenosine Dysfunction in Epilepsy and Associated Comorbidities. Curr Drug Targets 23(4):344\u2013357. https:\/\/doi.org\/10.2174\/1389450122666210928145258","journal-title":"Curr Drug Targets"},{"key":"3351_CR20","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x20666220706100136","author":"M Guo","year":"2022","unstructured":"Guo M, Xie P, Liu S, Luan G, Li T (2022) Epilepsy and Autism Spectrum Disorder (ASD): The underlying Mechanisms and Therapy Targets related with Adenosine. Curr Neuropharmacol. https:\/\/doi.org\/10.2174\/1570159x20666220706100136","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"3351_CR21","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/s0306-4522(02)00080-5","volume":"112","author":"LV Lopes","year":"2002","unstructured":"Lopes LV, Cunha RA, Kull B, Fredholm BB, Ribeiro JA (2002) Adenosine A(2A) receptor facilitation of hippocampal synaptic transmission is dependent on tonic A(1) receptor inhibition. Neuroscience. 112(2):319\u201329. https:\/\/doi.org\/10.1016\/s0306-4522(02)00080-5","journal-title":"Neuroscience."},{"issue":"47","key":"3351_CR22","doi-asserted-by":"publisher","first-page":"18492","DOI":"10.1523\/jneurosci.1828-13.2013","volume":"33","author":"M Matos","year":"2013","unstructured":"Matos M, Augusto E, Agostinho P, Cunha RA, Chen JF (2013) Antagonistic interaction between adenosine A2A receptors and Na+\/K+-ATPase-\u03b12 controlling glutamate uptake in astrocytes. J Neurosci\u202f: Off J Soc Neurosci 33(47):18492\u2013502. https:\/\/doi.org\/10.1523\/jneurosci.1828-13.2013","journal-title":"J Neurosci : Off J Soc Neurosci"},{"key":"3351_CR23","doi-asserted-by":"publisher","first-page":"104570","DOI":"10.1016\/j.nbd.2019.104570","volume":"132","author":"FQ Gon\u00e7alves","year":"2019","unstructured":"Gon\u00e7alves FQ, Lopes JP, Silva HB et al (2019) Synaptic and memory dysfunction in a \u03b2-amyloid model of early Alzheimer\u2019s disease depends on increased formation of ATP-derived extracellular adenosine. Neurobiol Dis 132:104570. https:\/\/doi.org\/10.1016\/j.nbd.2019.104570","journal-title":"Neurobiol Dis"},{"key":"3351_CR24","doi-asserted-by":"publisher","unstructured":"Stockwell J, Jakova E, Cayabyab FS (2017) Adenosine A1 and A2A Receptors in the Brain: Current Research and Their Role in Neurodegeneration. Molecules (Basel, Switzerland). 22(4)https:\/\/doi.org\/10.3390\/molecules22040676","DOI":"10.3390\/molecules22040676"},{"issue":"5","key":"3351_CR25","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1002\/glia.22290","volume":"60","author":"M Matos","year":"2012","unstructured":"Matos M, Augusto E, Santos-Rodrigues AD et al (2012) Adenosine A2A receptors modulate glutamate uptake in cultured astrocytes and gliosomes. Glia. 60(5):702\u201316. https:\/\/doi.org\/10.1002\/glia.22290","journal-title":"Glia."},{"issue":"11","key":"3351_CR26","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.biopsych.2015.02.026","volume":"78","author":"M Matos","year":"2015","unstructured":"Matos M, Shen HY, Augusto E et al (2015) Deletion of adenosine A2A receptors from astrocytes disrupts glutamate homeostasis leading to psychomotor and cognitive impairment: relevance to schizophrenia. Biol Psych 78(11):763\u201374. https:\/\/doi.org\/10.1016\/j.biopsych.2015.02.026","journal-title":"Biol Psych"},{"issue":"2","key":"3351_CR27","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1111\/bpa.12770","volume":"30","author":"X He","year":"2020","unstructured":"He X, Chen F, Zhang Y et al (2020) Upregulation of adenosine A2A receptor and downregulation of GLT1 is associated with neuronal cell death in Rasmussen\u2019s encephalitis. Brain Pathol (Zurich, Switzerland). 30(2):246\u2013260. https:\/\/doi.org\/10.1111\/bpa.12770","journal-title":"Brain Pathol (Zurich, Switzerland)."},{"issue":"3","key":"3351_CR28","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.pneurobio.2007.12.002","volume":"84","author":"D Boison","year":"2008","unstructured":"Boison D (2008) The adenosine kinase hypothesis of epileptogenesis. Progress Neurobiol 84(3):249\u201362. https:\/\/doi.org\/10.1016\/j.pneurobio.2007.12.002","journal-title":"Progress Neurobiol"},{"issue":"8","key":"3351_CR29","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1002\/glia.22285","volume":"60","author":"D Boison","year":"2012","unstructured":"Boison D (2012) Adenosine dysfunction in epilepsy. Glia. 60(8):1234\u20131243","journal-title":"Glia."},{"issue":"1","key":"3351_CR30","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1002\/glia.21250","volume":"60","author":"T Li","year":"2012","unstructured":"Li T, Lytle N, Lan JQ, Sandau US, Boison D (2012) Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: a first step in epileptogenesis? Glia. 60(1):83\u201395. https:\/\/doi.org\/10.1002\/glia.21250","journal-title":"Glia."},{"issue":"1","key":"3351_CR31","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1528-1167.2011.03306.x","volume":"53","author":"M de Groot","year":"2012","unstructured":"de Groot M, Iyer A, Zurolo E et al (2012) Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor-associated epilepsy. Epilepsia. 53(1):58\u201366. https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03306.x","journal-title":"Epilepsia."},{"issue":"3","key":"3351_CR32","doi-asserted-by":"publisher","first-page":"726","DOI":"10.3171\/2021.3.JNS21141","volume":"136","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang X, Tang C et al (2022) Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy. J Neurosurg. 136(3):726\u2013735. https:\/\/doi.org\/10.3171\/2021.3.JNS21141","journal-title":"J Neurosurg."},{"issue":"11","key":"3351_CR33","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1097\/01.jnen.0000435369.39388.5c","volume":"72","author":"G Luan","year":"2013","unstructured":"Luan G, Gao Q, Guan Y et al (2013) Upregulation of adenosine kinase in Rasmussen encephalitis. J Neuropathol Exp Neurol 72(11):1000\u20138. https:\/\/doi.org\/10.1097\/01.jnen.0000435369.39388.5c","journal-title":"J Neuropathol Exp Neurol"},{"issue":"8","key":"3351_CR34","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1093\/jnen\/nlx053","volume":"76","author":"G Luan","year":"2017","unstructured":"Luan G, Wang X, Gao Q et al (2017) Upregulation of Neuronal Adenosine A1 Receptor in Human Rasmussen Encephalitis. J Neuropathol Exp Neurol 76(8):720\u2013731. https:\/\/doi.org\/10.1093\/jnen\/nlx053","journal-title":"J Neuropathol Exp Neurol"},{"issue":"1\u20132","key":"3351_CR35","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/0006-8993(95)01313-X","volume":"710","author":"M Glass","year":"1996","unstructured":"Glass M, Faull RL, Bullock JY et al (1996) Loss of A1 adenosine receptors in human temporal lobe epilepsy. Brain Res. 710(1\u20132):56\u201368","journal-title":"Brain Res."},{"issue":"3","key":"3351_CR36","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1124\/pr.112.006361","volume":"65","author":"D Boison","year":"2013","unstructured":"Boison D (2013) Adenosine kinase: exploitation for therapeutic gain. Pharmacol Rev 65(3):906\u201343. https:\/\/doi.org\/10.1124\/pr.112.006361","journal-title":"Pharmacol Rev"},{"issue":"19","key":"3351_CR37","doi-asserted-by":"publisher","first-page":"2527","DOI":"10.1091\/mbc.E19-03-0136","volume":"30","author":"L Shi","year":"2019","unstructured":"Shi L, Wu Z, Miao J et al (2019) Adenosine interaction with adenosine receptor A2a promotes gastric cancer metastasis by enhancing PI3K-AKT-mTOR signaling. Mole Biol Cell 30(19):2527\u20132534. https:\/\/doi.org\/10.1091\/mbc.E19-03-0136","journal-title":"Mole Biol Cell"},{"issue":"5","key":"3351_CR38","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s10147-022-02123-x","volume":"27","author":"G Liu","year":"2022","unstructured":"Liu G, Yang S, Liu Y et al (2022) The adenosine-A2a receptor regulates the radioresistance of gastric cancer via PI3K-AKT-mTOR pathway. Int J Clin Oncol 27(5):911\u2013920. https:\/\/doi.org\/10.1007\/s10147-022-02123-x","journal-title":"Int J Clin Oncol"},{"issue":"6 Suppl 3","key":"3351_CR39","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1212\/01.wnl.0000114507.30388.7e","volume":"62","author":"A Palmini","year":"2004","unstructured":"Palmini A, Najm I, Avanzini G et al (2004) Terminology and classification of the cortical dysplasias. Neurology. 62(6 Suppl 3):S2-8. https:\/\/doi.org\/10.1212\/01.wnl.0000114507.30388.7e","journal-title":"Neurology."},{"key":"3351_CR40","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.eplepsyres.2016.03.005","volume":"123","author":"G Luan","year":"2016","unstructured":"Luan G, Gao Q, Zhai F, Chen Y, Li T (2016) Upregulation of HMGB1, toll-like receptor and RAGE in human Rasmussen\u2019s encephalitis. Epilepsy Res 123:36\u201349. https:\/\/doi.org\/10.1016\/j.eplepsyres.2016.03.005","journal-title":"Epilepsy Res"},{"key":"3351_CR41","doi-asserted-by":"crossref","unstructured":"Bautista JF, L\u00fcders HO (2000) Semiological seizure classification: relevance to pediatric epilepsy. Epileptic Disord : Int epilepsy J Videotape. 2(1):65-72; discussion 73","DOI":"10.1684\/j.1950-6945.2000.tb00353.x"},{"issue":"9","key":"3351_CR42","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1528-1157.1998.tb01452.x","volume":"39","author":"H L\u00fcders","year":"1998","unstructured":"L\u00fcders H, Acharya J, Baumgartner C et al (1998) Semiological seizure classification. Epilepsia. 39(9):1006\u201313. https:\/\/doi.org\/10.1111\/j.1528-1157.1998.tb01452.x","journal-title":"Epilepsia."},{"issue":"Pt 5","key":"3351_CR43","doi-asserted-by":"publisher","first-page":"1276","DOI":"10.1093\/brain\/awm057","volume":"130","author":"T Li","year":"2007","unstructured":"Li T, Steinbeck JA, Lusardi T et al (2007) Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain\u202f: J Neurol 130(Pt 5):1276\u201388. https:\/\/doi.org\/10.1093\/brain\/awm057","journal-title":"Brain : J Neurol"},{"issue":"3","key":"3351_CR44","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1124\/pharmrev.121.000528","volume":"74","author":"GG Yegutkin","year":"2022","unstructured":"Yegutkin GG, Boison D (2022) ATP and Adenosine Metabolism in Cancer: Exploitation for Therapeutic Gain. Pharmacol Rev 74(3):797\u2013822. https:\/\/doi.org\/10.1124\/pharmrev.121.000528","journal-title":"Pharmacol Rev"},{"key":"3351_CR45","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1016\/j.ccell.2019.10.007","volume":"36","author":"D Boison","year":"2019","unstructured":"Boison D, Yegutkin GG (2019) Adenosine metabolism: emerging concepts for cancer therapy. Cancer Cell 36:582\u2013596","journal-title":"Cancer Cell"},{"issue":"5","key":"3351_CR46","doi-asserted-by":"publisher","first-page":"618","DOI":"10.1002\/ana.410320504","volume":"32","author":"MJ During","year":"1992","unstructured":"During MJ, Spencer DD (1992) Adenosine: a potential mediator of seizure arrest and postictal refractoriness. Ann Neurol 32(5):618\u201324","journal-title":"Ann Neurol"},{"issue":"7","key":"3351_CR47","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/cdd.2009.131","volume":"17","author":"D Boison","year":"2010","unstructured":"Boison D, Chen JF, Fredholm BB (2010) Adenosine signaling and function in glial cells. Cell Death Differ. 17(7):1071\u201382. https:\/\/doi.org\/10.1038\/cdd.2009.131","journal-title":"Cell Death Differ."},{"issue":"2\u20133","key":"3351_CR48","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.neulet.2004.08.031","volume":"370","author":"DE Fedele","year":"2004","unstructured":"Fedele DE, Koch P, Br\u00fcstle O et al (2004) Engineering embryonic stem cell derived glia for adenosine delivery. Neurosci Lett. 370(2\u20133):160\u2013165","journal-title":"Neurosci Lett."},{"issue":"4","key":"3351_CR49","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/epi.16487","volume":"61","author":"S Patodia","year":"2020","unstructured":"Patodia S, Paradiso B, Garcia M et al (2020) Adenosine kinase and adenosine receptors A(1) R and A(2A) R in temporal lobe epilepsy and hippocampal sclerosis and association with risk factors for SUDEP. Epilepsia. 61(4):787\u2013797. https:\/\/doi.org\/10.1111\/epi.16487","journal-title":"Epilepsia."},{"issue":"9","key":"3351_CR50","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.1111\/j.1528-1167.2011.03115.x","volume":"52","author":"E Aronica","year":"2011","unstructured":"Aronica E, Zurolo E, Iyer A et al (2011) Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy. Epilepsia. 52(9):1645\u201355. https:\/\/doi.org\/10.1111\/j.1528-1167.2011.03115.x","journal-title":"Epilepsia."},{"issue":"1","key":"3351_CR51","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.bbrc.2009.07.106","volume":"388","author":"XA Cui","year":"2009","unstructured":"Cui XA, Singh B, Park J, Gupta RS (2009) Subcellular localization of adenosine kinase in mammalian cells: The long isoform of AdK is localized in the nucleus. Biochem Biophys Res Commun 388(1):46\u201350. https:\/\/doi.org\/10.1016\/j.bbrc.2009.07.106","journal-title":"Biochem Biophys Res Commun"},{"issue":"7","key":"3351_CR52","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1016\/j.neuint.2013.01.028","volume":"63","author":"E Aronica","year":"2013","unstructured":"Aronica E, Sandau US, Iyer A, Boison D (2013) Glial adenosine kinase\u2013a neuropathological marker of the epileptic brain. Neurochem Int 63(7):688\u201395. https:\/\/doi.org\/10.1016\/j.neuint.2013.01.028","journal-title":"Neurochem Int"},{"key":"3351_CR53","doi-asserted-by":"publisher","unstructured":"Studer FE, Fedele DE, Marowsky A, et al (2006) Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience. 142(1):125-37. S0306-4522(06)00812-8 [pii] https:\/\/doi.org\/10.1016\/j.neuroscience.2006.06.016","DOI":"10.1016\/j.neuroscience.2006.06.016"},{"issue":"6568","key":"3351_CR54","doi-asserted-by":"publisher","first-page":"eabk2055","DOI":"10.1126\/science.abk2055","volume":"374","author":"F Gomez-Castro","year":"2021","unstructured":"Gomez-Castro F, Zappettini S, Pressey JC et al (2021) Convergence of adenosine and GABA signaling for synapse stabilization during development. Science (New York, NY) 374(6568):eabk2055. https:\/\/doi.org\/10.1126\/science.abk2055","journal-title":"Science (New York, NY)"},{"issue":"197","key":"3351_CR55","doi-asserted-by":"publisher","first-page":"197ra104","DOI":"10.1126\/scitranslmed.3006258","volume":"5","author":"CG Silva","year":"2013","unstructured":"Silva CG, M\u00e9tin C, Fazeli W et al (2013) Adenosine receptor antagonists including caffeine alter fetal brain development in mice. Sci Transl Med 5(197):197ra104. https:\/\/doi.org\/10.1126\/scitranslmed.3006258","journal-title":"Sci Transl Med"},{"issue":"12","key":"3351_CR56","doi-asserted-by":"publisher","first-page":"5652","DOI":"10.1093\/cercor\/bhab188","volume":"31","author":"S Al\u00e7ada-Morais","year":"1991","unstructured":"Al\u00e7ada-Morais S, Gon\u00e7alves N, Moreno-Juan V et al (1991) 2021 Adenosine A2A Receptors Contribute to the Radial Migration of Cortical Projection Neurons through the Regulation of Neuronal Polarization and Axon Formation. Cerebral Cortex (New York, NY 1991) 31(12):5652\u20135663. https:\/\/doi.org\/10.1093\/cercor\/bhab188","journal-title":"Cerebral Cortex (New York, NY 1991)"},{"issue":"4","key":"3351_CR57","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1007\/s11302-016-9535-2","volume":"12","author":"AR Barros-Barbosa","year":"2016","unstructured":"Barros-Barbosa AR, Ferreirinha F, Oliveira \u00c2 et al (2016) Adenosine A(2A) receptor and ecto-5\u2019-nucleotidase\/CD73 are upregulated in hippocampal astrocytes of human patients with mesial temporal lobe epilepsy (MTLE). Purinergic Signal 12(4):719\u2013734. https:\/\/doi.org\/10.1007\/s11302-016-9535-2","journal-title":"Purinergic Signal"},{"issue":"2","key":"3351_CR58","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.nbd.2007.04.018","volume":"27","author":"CG Silva","year":"2007","unstructured":"Silva CG, Porci\u00fancula LO, Canas PM, Oliveira CR, Cunha RA (2007) Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol Dis 27(2):182\u20139. https:\/\/doi.org\/10.1016\/j.nbd.2007.04.018","journal-title":"Neurobiol Dis"},{"issue":"11 Suppl 6","key":"3351_CR59","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1212\/01.wnl.0000095216.89483.a2","volume":"61","author":"P Popoli","year":"2003","unstructured":"Popoli P, Frank C, Tebano MT et al (2003) Modulation of glutamate release and excitotoxicity by adenosine A2A receptors. Neurology. 61(11 Suppl 6):S69-71. https:\/\/doi.org\/10.1212\/01.wnl.0000095216.89483.a2","journal-title":"Neurology."},{"issue":"6","key":"3351_CR60","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1111\/j.1460-9568.2009.06897.x","volume":"30","author":"I D'Alimonte","year":"2009","unstructured":"D\u2019Alimonte I, D\u2019Auro M, Citraro R et al (2009) Altered distribution and function of A2A adenosine receptors in the brain of WAG\/Rij rats with genetic absence epilepsy, before and after appearance of the disease. Eur J Neurosci 30(6):1023\u201335. https:\/\/doi.org\/10.1111\/j.1460-9568.2009.06897.x","journal-title":"Eur J Neurosci"},{"key":"3351_CR61","doi-asserted-by":"publisher","unstructured":"Li X, Kang H, Liu X, et al 2012 Effect of adenosine A2A receptor antagonist ZM241385 on amygdala-kindled seizures and progression of amygdala kindling. Journal of Huazhong University of Science and Technology Medical sciences = Hua zhong ke ji da xue xue bao Yi xue Ying De wen ban = Huazhong keji daxue xuebao Yixue Yingdewen ban. 32(2):257-264. https:\/\/doi.org\/10.1007\/s11596-012-0046-2","DOI":"10.1007\/s11596-012-0046-2"},{"issue":"2","key":"3351_CR62","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/caff.2019.0022","volume":"10","author":"FC Tescarollo","year":"2020","unstructured":"Tescarollo FC, Rombo DM, DeLiberto LK et al (2020) Role of Adenosine in Epilepsy and Seizures. J Caffeine Adenosine Res 10(2):45\u201360. https:\/\/doi.org\/10.1089\/caff.2019.0022","journal-title":"J Caffeine Adenosine Res"},{"issue":"1","key":"3351_CR63","doi-asserted-by":"publisher","first-page":"14690","DOI":"10.1038\/s41598-022-18884-4","volume":"12","author":"X Xu","year":"2022","unstructured":"Xu X, Beleza RO, Gon\u00e7alves FQ et al (2022) Adenosine A(2A) receptors control synaptic remodeling in the adult brain. Sci Rep 12(1):14690. https:\/\/doi.org\/10.1038\/s41598-022-18884-4","journal-title":"Sci Rep"},{"issue":"3","key":"3351_CR64","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1016\/s0028-3908(00)00173-8","volume":"40","author":"M El Yacoubi","year":"2001","unstructured":"El Yacoubi M, Ledent C, Parmentier M, Daoust M, Costentin J, Vaugeois J (2001) Absence of the adenosine A(2A) receptor or its chronic blockade decrease ethanol withdrawal-induced seizures in mice. Neuropharmacology. 40(3):424\u201332. https:\/\/doi.org\/10.1016\/s0028-3908(00)00173-8","journal-title":"Neuropharmacology."},{"issue":"1","key":"3351_CR65","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuropharm.2008.04.007","volume":"55","author":"M El Yacoubi","year":"2008","unstructured":"El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM (2008) Evidence for the involvement of the adenosine A(2A) receptor in the lowered susceptibility to pentylenetetrazol-induced seizures produced in mice by long-term treatment with caffeine. Neuropharmacology. 55(1):35\u201340. https:\/\/doi.org\/10.1016\/j.neuropharm.2008.04.007","journal-title":"Neuropharmacology."},{"issue":"2","key":"3351_CR66","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.phrs.2007.04.011","volume":"56","author":"N Hosseinmardi","year":"2007","unstructured":"Hosseinmardi N, Mirnajafi-Zadeh J, Fathollahi Y, Shahabi P (2007) The role of adenosine A1 and A2A receptors of entorhinal cortex on piriform cortex kindled seizures in rats. Pharmacol Res 56(2):110\u20137. https:\/\/doi.org\/10.1016\/j.phrs.2007.04.011","journal-title":"Pharmacol Res"},{"issue":"1","key":"3351_CR67","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.seizure.2005.10.006","volume":"15","author":"M Zeraati","year":"2006","unstructured":"Zeraati M, Mirnajafi-Zadeh J, Fathollahi Y, Namvar S, Rezvani ME (2006) Adenosine A1 and A2A receptors of hippocampal CA1 region have opposite effects on piriform cortex kindled seizures in rats. Seizure. 15(1):41\u20138. https:\/\/doi.org\/10.1016\/j.seizure.2005.10.006","journal-title":"Seizure."},{"issue":"9","key":"3351_CR68","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.1111\/j.0953-816X.2004.03355.x","volume":"19","author":"LA Etherington","year":"2004","unstructured":"Etherington LA, Frenguelli BG (2004) Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. Eur J Neurosci 19(9):2539\u201350. https:\/\/doi.org\/10.1111\/j.0953-816X.2004.03355.x","journal-title":"Eur J Neurosci"},{"issue":"3","key":"3351_CR69","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s00210-009-0426-8","volume":"380","author":"M El Yacoubi","year":"2009","unstructured":"El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM (2009) Adenosine A2A receptor deficient mice are partially resistant to limbic seizures. Naunyn-Schmiedeberg\u2019s arch Pharmacol 380(3):223\u201332. https:\/\/doi.org\/10.1007\/s00210-009-0426-8","journal-title":"Naunyn-Schmiedeberg's arch Pharmacol"},{"issue":"6","key":"3351_CR70","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1152\/jn.1999.82.6.3196","volume":"82","author":"LV Lopes","year":"1999","unstructured":"Lopes LV, Cunha RA, Ribeiro JA (1999) Cross talk between A(1) and A(2A) adenosine receptors in the hippocampus and cortex of young adult and old rats. J Neurophysiol 82(6):3196\u2013203. https:\/\/doi.org\/10.1152\/jn.1999.82.6.3196","journal-title":"J Neurophysiol"},{"key":"3351_CR71","doi-asserted-by":"publisher","unstructured":"Canas PM, Porci\u00fancula LO, Sim\u00f5es AP, et al (2018) Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Triggered by Convulsions. eNeuro. 5(6) https:\/\/doi.org\/10.1523\/eneuro.0385-18.2018","DOI":"10.1523\/eneuro.0385-18.2018"},{"issue":"6","key":"3351_CR72","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1111\/jnc.13724","volume":"139","author":"RA Cunha","year":"2016","unstructured":"Cunha RA (2016) How does adenosine control neuronal dysfunction and neurodegeneration? J Neurochem 139(6):1019\u20131055. https:\/\/doi.org\/10.1111\/jnc.13724","journal-title":"J Neurochem"},{"key":"3351_CR73","doi-asserted-by":"publisher","unstructured":"Gomes CV, Kaster MP, Tome AR, Agostinho PM, Cunha RA (2011) Adenosine receptors and brain diseases: neuroprotection and neurodegeneration. Biochim Biophys Acta. May 1808(5):1380-99. S0005-2736(10)00423-2 [pii] https:\/\/doi.org\/10.1016\/j.bbamem.2010.12.001","DOI":"10.1016\/j.bbamem.2010.12.001"},{"issue":"3","key":"3351_CR74","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1212\/WNL.0b013e3181cc89e3","volume":"74","author":"EE Benarroch","year":"2010","unstructured":"Benarroch EE (2010) Glutamate transporters: diversity, function, and involvement in neurologic disease. Neurology. 74(3):259\u201364. https:\/\/doi.org\/10.1212\/WNL.0b013e3181cc89e3","journal-title":"Neurology."},{"issue":"9","key":"3351_CR75","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1046\/j.0953-816x.2001.01779.x","volume":"14","author":"E Aronica","year":"2001","unstructured":"Aronica E, van Vliet EA, Hendriksen E, Troost D, Lopes da Silva FH, Gorter JA (2001) Cystatin C, a cysteine protease inhibitor, is persistently up-regulated in neurons and glia in a rat model for mesial temporal lobe epilepsy. The European journal of neuroscience 14(9):1485\u201391. https:\/\/doi.org\/10.1046\/j.0953-816x.2001.01779.x","journal-title":"The European journal of neuroscience"},{"issue":"1\u20132","key":"3351_CR76","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0304-3940(94)11548-1","volume":"191","author":"TG Beach","year":"1995","unstructured":"Beach TG, Woodhurst WB, MacDonald DB, Jones MW (1995) Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy. Neurosci Lett 191(1\u20132):27\u201330. https:\/\/doi.org\/10.1016\/0304-3940(94)11548-1","journal-title":"Neurosci Lett"},{"issue":"10","key":"3351_CR77","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1007\/bf01191558","volume":"23","author":"J Niquet","year":"1994","unstructured":"Niquet J, Ben-Ari Y, Represa A (1994) Glial reaction after seizure induced hippocampal lesion: immunohistochemical characterization of proliferating glial cells. J Neurocytol 23(10):641\u201356. https:\/\/doi.org\/10.1007\/bf01191558","journal-title":"J Neurocytol"},{"issue":"1","key":"3351_CR78","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/0304-3940(96)13062-7","volume":"217","author":"Y Taniwaki","year":"1996","unstructured":"Taniwaki Y, Kato M, Araki T, Kobayashi T (1996) Microglial activation by epileptic activities through the propagation pathway of kainic acid-induced hippocampal seizures in the rat. Neurosci Lett 217(1):29\u201332. https:\/\/doi.org\/10.1016\/0304-3940(96)13062-7","journal-title":"Neurosci Lett"},{"issue":"3","key":"3351_CR79","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1111\/j.1365-2990.2004.00636.x","volume":"31","author":"E Aronica","year":"2005","unstructured":"Aronica E, Gorter JA, Redeker S et al (2005) Distribution, characterization and clinical significance of microglia in glioneuronal tumours from patients with chronic intractable epilepsy. Neuropathol Appl Neurobiol 31(3):280\u201391. https:\/\/doi.org\/10.1111\/j.1365-2990.2004.00636.x","journal-title":"Neuropathol Appl Neurobiol"},{"key":"3351_CR80","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1146\/annurev-pathol-052016-100138","volume":"12","author":"PH Iffland 2nd","year":"2017","unstructured":"Iffland PH 2nd, Crino PB (2017) Focal Cortical Dysplasia: Gene Mutations, Cell Signaling, and Therapeutic Implications. Ann Rev Pathol 12:547\u2013571. https:\/\/doi.org\/10.1146\/annurev-pathol-052016-100138","journal-title":"Ann Rev Pathol"},{"issue":"12","key":"3351_CR81","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1038\/s41568-018-0074-8","volume":"18","author":"D Mossmann","year":"2018","unstructured":"Mossmann D, Park S, Hall MN (2018) mTOR signalling and cellular metabolism are mutual determinants in cancer. Nat Rev Cancer. 18(12):744\u2013757. https:\/\/doi.org\/10.1038\/s41568-018-0074-8","journal-title":"Nat Rev Cancer."},{"issue":"3","key":"3351_CR82","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1080\/14737175.2018.1428562","volume":"18","author":"P Curatolo","year":"2018","unstructured":"Curatolo P, Moavero R, van Scheppingen J, Aronica E (2018) mTOR dysregulation and tuberous sclerosis-related epilepsy. Exp Rev Neurotherapeut 18(3):185\u2013201. https:\/\/doi.org\/10.1080\/14737175.2018.1428562","journal-title":"Exp Rev Neurotherapeut"},{"key":"3351_CR83","doi-asserted-by":"publisher","first-page":"106282","DOI":"10.1016\/j.eplepsyres.2020.106282","volume":"161","author":"SL Hodges","year":"2020","unstructured":"Hodges SL, Lugo JN (2020) Therapeutic role of targeting mTOR signaling and neuroinflammation in epilepsy. Epilepsy Res 161:106282. https:\/\/doi.org\/10.1016\/j.eplepsyres.2020.106282","journal-title":"Epilepsy Res"},{"key":"3351_CR84","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","volume":"52","author":"K Inoki","year":"2012","unstructured":"Inoki K, Kim J, Guan KL (2012) AMPK and mTOR in cellular energy homeostasis and drug targets. Ann Rev Pharmacol Toxicol 52:381\u2013400. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010611-134537","journal-title":"Ann Rev Pharmacol Toxicol"},{"issue":"6553","key":"3351_CR85","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1126\/science.abe7565","volume":"373","author":"Y Yan","year":"2021","unstructured":"Yan Y, Mukherjee S, Harikumar KG et al (2021) Structure of an AMPK complex in an inactive, ATP-bound state. Science (New York, NY). 373(6553):413\u2013419. https:\/\/doi.org\/10.1126\/science.abe7565","journal-title":"Science (New York, NY)."},{"issue":"1","key":"3351_CR86","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/nan.12463","volume":"44","author":"E Marsan","year":"2018","unstructured":"Marsan E, Baulac S (2018) Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy. Neuropathol Appl Neurobiol 44(1):6\u201317. https:\/\/doi.org\/10.1111\/nan.12463","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"4","key":"3351_CR87","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1002\/ana.20949","volume":"60","author":"MC Ljungberg","year":"2006","unstructured":"Ljungberg MC, Bhattacharjee MB, Lu Y et al (2006) Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia. Ann Neurol 60(4):420\u20139. https:\/\/doi.org\/10.1002\/ana.20949","journal-title":"Ann Neurol"},{"key":"3351_CR88","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/2051-5960-2-71","volume":"2","author":"J Liu","year":"2014","unstructured":"Liu J, Reeves C, Michalak Z et al (2014) Evidence for mTOR pathway activation in a spectrum of epilepsy-associated pathologies. Acta Neuropathol Commun 2:71. https:\/\/doi.org\/10.1186\/2051-5960-2-71","journal-title":"Acta Neuropathol Commun"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03351-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03351-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03351-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,19]],"date-time":"2024-10-19T05:22:48Z","timestamp":1729315368000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03351-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,27]]},"references-count":88,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["3351"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03351-6","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2189762\/v1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,27]]},"assertion":[{"value":"21 October 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 April 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 April 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors have no relevant financial or non-financial interests to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the local ethics committee (Beijing Sanbo Hospital, Capital Medical University, Beijing, China).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Informed consent was obtained from parents or legal guardians of all participants.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}}]}}