{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:24:34Z","timestamp":1793316274461,"version":"4.5.0"},"reference-count":87,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1007\/s12035-023-03387-8","type":"journal-article","created":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T12:52:49Z","timestamp":1685710369000},"page":"5155-5166","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The Role of Tau Proteoforms in Health and Disease"],"prefix":"10.1007","volume":"60","author":[{"given":"Zuha","family":"Waheed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawaria","family":"Choudhary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faria Hasan","family":"Jatala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Fatimah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8692-3161","authenticated-orcid":false,"given":"Aneeqa","family":"Noor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Zerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saima","family":"Zafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"issue":"1","key":"3387_CR1","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1146\/annurev-neuro-072116-031153","volume":"40","author":"M Goedert","year":"2017","unstructured":"Goedert M, Eisenberg DS, Crowther RA (2017) Propagation of tau aggregates and neurodegeneration. Annu Rev Neurosci 40(1):189\u2013210. https:\/\/doi.org\/10.1146\/annurev-neuro-072116-031153","journal-title":"Annu Rev Neurosci"},{"key":"3387_CR2","doi-asserted-by":"publisher","first-page":"101644","DOI":"10.1016\/j.pneurobio.2019.101644","volume":"180","author":"TW Roesler","year":"2019","unstructured":"Roesler TW, Marvian AT, Brendel M, Nykaenen NP, Hoellerhage M, Schwarz SC, Hopfner F, Koeglsperger T, et al (2019) Four-repeat tauopathies. Prog neurobiol 180:101644. https:\/\/doi.org\/10.1016\/j.pneurobio.2019.101644","journal-title":"Four-repeat tauopathies. Prog neurobiol"},{"issue":"7880","key":"3387_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1038\/s41586-021-03911-7","volume":"598","author":"Y Shi","year":"2021","unstructured":"Shi Y, Zhang W, Yang Y, Murzin AG, Falcon B, Kotecha A, van Beers M, Tarutani A, et al (2021) Structure-based classification of tauopathies. Nature 598(7880):359\u2013363. https:\/\/doi.org\/10.1038\/s41586-021-03911-7","journal-title":"Nature"},{"issue":"1","key":"3387_CR4","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1038\/s41467-022-28896-3","volume":"13","author":"N Franzmeier","year":"2022","unstructured":"Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, et al (2022) Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nat Comm 13(1):1362. https:\/\/doi.org\/10.1038\/s41467-022-28896-3","journal-title":"Nat Comm"},{"key":"3387_CR5","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3389\/fnmol.2013.00057","volume":"6","author":"ML Caillet-Boudin","year":"2014","unstructured":"Caillet-Boudin ML, Fernandez-Gomez FJ, Tran H, Dhaenens CM, Buee L, Sergeant N (2014) Brain pathology in myotonic dystrophy: when tauopathy meets spliceopathy and RNAopathy. Front Mol Neuro 6:57. https:\/\/doi.org\/10.3389\/fnmol.2013.00057","journal-title":"Front Mol Neuro"},{"key":"3387_CR6","doi-asserted-by":"publisher","first-page":"702788","DOI":"10.3389\/fnins.2021.702788","volume":"15","author":"V Hook","year":"2021","unstructured":"Hook V, Boyarko B (2021) Human tau isoforms and proteolysis for production of toxic tau fragments in neurodegeneration. Front Neurosci 15:702788. https:\/\/doi.org\/10.3389\/fnins.2021.702788","journal-title":"Front Neurosci"},{"key":"3387_CR7","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnagi.2019.00204","volume":"11","author":"P Barbier","year":"2019","unstructured":"Barbier P, Zejneli O, Martinho M et al (2019) Role of tau as a microtubule-associated protein: structural and functional aspects. Front Aging Neurosci 11:204. https:\/\/doi.org\/10.3389\/fnagi.2019.00204","journal-title":"Front Aging Neurosci"},{"issue":"3","key":"3387_CR8","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1042\/0264-6021:3570759","volume":"357","author":"J Eidenmuller","year":"2001","unstructured":"Eidenmuller J, Fath T, Maas T, Pool M, Sontag E, Brandt R (2001) Phosphorylation-mimicking glutamate clusters in the proline-rich region are sufficient to simulate the functional deficiencies of hyperphosphorylated tau protein. Biochem J 357(3):759\u2013767. https:\/\/doi.org\/10.1042\/0264-6021:3570759","journal-title":"Biochem J"},{"issue":"2","key":"3387_CR9","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1242\/jcs.01655","volume":"118","author":"C Feijoo","year":"2005","unstructured":"Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A (2005) Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4\/p38 at Thr50 promotes microtubule assembly. J Cell Sci 118(2):397\u2013408. https:\/\/doi.org\/10.1242\/jcs.01655","journal-title":"J Cell Sci"},{"issue":"1","key":"3387_CR10","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0006-3495(03)74468-3","volume":"85","author":"CE Morris","year":"2003","unstructured":"Morris CE, Wang JA, Markin VS (2003) The invagination of excess surface area by shrinking neurons. Biophys J 85(1):223\u2013235. https:\/\/doi.org\/10.1016\/S0006-3495(03)74468-3","journal-title":"Biophys J"},{"issue":"3","key":"3387_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s12031-011-9593-4","volume":"45","author":"M Goedert","year":"2011","unstructured":"Goedert M, Spillantini MG (2011) Pathogenesis of the tauopathies. J Mol Neurosci 45(3):425\u2013431. https:\/\/doi.org\/10.1007\/s12031-011-9593-4","journal-title":"J Mol Neurosci"},{"issue":"24","key":"3387_CR12","doi-asserted-by":"publisher","first-page":"20711","DOI":"10.1074\/jbc.M112.364067","volume":"287","author":"Z Qi","year":"2012","unstructured":"Qi Z, Erin EC, Haikady NN, Jeff K (2012) Tau isoform composition influences rate and extent of filament formation. J Bio Chem 287(24):20711\u201320719. https:\/\/doi.org\/10.1074\/jbc.M112.364067","journal-title":"J Bio Chem"},{"issue":"7","key":"3387_CR13","doi-asserted-by":"publisher","first-page":"a006247","DOI":"10.1101\/cshperspect.a006247","volume":"2","author":"EM Mandelkow","year":"2012","unstructured":"Mandelkow EM, Mandelkow E (2012) Biochemistry and cell biology of tau protein in neurofibrillary degeneration. Cold Spring Harb Perspect Med 2(7):a006247. https:\/\/doi.org\/10.1101\/cshperspect.a006247","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"5","key":"3387_CR14","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1111\/j.1440-1789.2006.00743.x","volume":"26","author":"M Yoshida","year":"2006","unstructured":"Yoshida M (2006) Cellular tau pathology and immunohistochemical study of tau isoforms in sporadic tauopathies. Neuropathol 26(5):457\u2013470. https:\/\/doi.org\/10.1111\/j.1440-1789.2006.00743.x","journal-title":"Neuropathol"},{"issue":"1","key":"3387_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41598-017-12955-7","volume":"7","author":"V Huin","year":"2017","unstructured":"Huin V, Buee L, Behal H et al (2017) Alternative promoter usage generates novel shorter MAPT mRNA transcripts in Alzheimer\u2019s disease and progressive supranuclear palsy brains. Sci Rep 7(1):1\u201310. https:\/\/doi.org\/10.1038\/s41598-017-12955-7","journal-title":"Sci Rep"},{"key":"3387_CR16","doi-asserted-by":"publisher","first-page":"3","DOI":"10.3390\/genes13030401","volume":"13","author":"Q Liu","year":"2022","unstructured":"Liu Q, Fang L, Wu C (2022) Alternative splicing and isoforms: from mechanisms to diseases. Genes 13:3\u2013401. https:\/\/doi.org\/10.3390\/genes13030401","journal-title":"Genes"},{"key":"3387_CR17","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1371\/journal.pone.0157924","volume":"11","author":"KG Coupland","year":"2016","unstructured":"Coupland KG, Kim WS, Halliday GM, Hallupp M, Dobson-Stone C, Kwok JB (2016) Role of the long non-coding RNA MAPT-AS1 in regulation of microtubule associated protein tau (MAPT) expression in Parkinson\u2019s disease. PLoS One 11:6-e0157924. https:\/\/doi.org\/10.1371\/journal.pone.0157924","journal-title":"PLoS ONE"},{"key":"3387_CR18","doi-asserted-by":"publisher","unstructured":"Lan Z, Chen Y, Jin J, Xu Y, Zhu X (2021) Long non-coding RNA: insight into mechanisms of Alzheimer\u2019s disease. Front Mol Neurosci 14. https:\/\/doi.org\/10.3389\/fnmol.2021.821002","DOI":"10.3389\/fnmol.2021.821002"},{"key":"3387_CR19","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-015-0025-8","volume":"10","author":"ML Caillet-Boudin","year":"2015","unstructured":"Caillet-Boudin ML, Buee L, Sergeant N, Lefebvre B (2015) Regulation of human MAPT gene expression. Mol Neurodegener 10:28. https:\/\/doi.org\/10.1186\/s13024-015-0025-8","journal-title":"Mol Neurodegener"},{"key":"3387_CR20","doi-asserted-by":"publisher","first-page":"1019999","DOI":"10.3389\/fnmol.2022.1019999","volume":"15","author":"I Fischer","year":"2022","unstructured":"Fischer I (2022) Evolutionary perspective of Big tau structure: 4a exon variants of MAPT. Front Mol Neurosci 15:1019999. https:\/\/doi.org\/10.3389\/fnmol.2022.1019999","journal-title":"Front Mol Neurosci"},{"issue":"10","key":"3387_CR21","doi-asserted-by":"publisher","first-page":"4378","DOI":"10.1073\/pnas.89.10.4378","volume":"89","author":"D Couchie","year":"1992","unstructured":"Couchie D, Mavilia C, Georgieff IS, Liem RK, Shelanski ML, Nunez J (1992) Primary structure of high molecular weight tau present in the peripheral nervous system. Proc Natl Acad 89(10):4378\u20134381. https:\/\/doi.org\/10.1073\/pnas.89.10.4378","journal-title":"Proc Natl Acad"},{"issue":"2\u20133","key":"3387_CR22","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.bbadis.2004.08.010","volume":"1739","author":"A Andreadis","year":"2005","unstructured":"Andreadis A (2005) Tau gene alternative splicing: expression patterns, regulation and modulation of function in normal brain and neurodegenerative diseases. Biochem Biophys acta 1739(2\u20133):91\u2013103. https:\/\/doi.org\/10.1016\/j.bbadis.2004.08.010","journal-title":"Biochem Biophys acta"},{"key":"3387_CR23","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3390\/biom6020021","volume":"6","author":"M Medina","year":"2016","unstructured":"Medina M, Hernendez F, Avila J (2016) New features about tau function and dysfunction. Biomolecules 6:2\u201321. https:\/\/doi.org\/10.3390\/biom6020021","journal-title":"Biomolecules"},{"key":"3387_CR24","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3390\/cells11050840","volume":"11","author":"D Ruiz-Gabarre","year":"2022","unstructured":"Ruiz-Gabarre D, Carnero-Espejo A, \u00c5vila J, Garcia-Escudero V (2022) What\u2019s in a gene? The outstanding diversity of MAPT. Cells 11:5\u2013840. https:\/\/doi.org\/10.3390\/cells11050840","journal-title":"Cells"},{"issue":"1","key":"3387_CR25","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00401-021-02317-z","volume":"142","author":"V Garcia-Escudero","year":"2021","unstructured":"Garcia-Escudero V, Ruiz-Gabarre D, Gargini R, Perez M et al (2021) A new non-aggregative splicing isoform of human Tau is decreased in Alzheimer\u2019s disease. Acta Neuropathol 142(1):159\u2013177. https:\/\/doi.org\/10.1007\/s00401-021-02317-z","journal-title":"Acta Neuropathol"},{"issue":"21","key":"3387_CR26","doi-asserted-by":"publisher","first-page":"12841","DOI":"10.3390\/ijms232112841","volume":"23","author":"P Rawat","year":"2022","unstructured":"Rawat P, Sehar U, Bisht J, Selman A, Culberson J, Reddy PH (2022) Phosphorylated tau in Alzheimer\u2019s disease and other tauopathies. Int J Mol Sci 23(21):12841. https:\/\/doi.org\/10.3390\/ijms232112841","journal-title":"Int J Mol Sci"},{"key":"3387_CR27","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1073\/pnas.2204179119","volume":"119","author":"ZK Ngian","year":"2022","unstructured":"Ngian ZK, Tan YY, Choo CT, Lin WQ et al (2022) Truncated Tau caused by intron retention is enriched in Alzheimer\u2019s disease cortex and exhibits altered biochemical properties. Proc Natl Acad 119:37-e2204179119. https:\/\/doi.org\/10.1073\/pnas.2204179119","journal-title":"Proc Natl Acad"},{"issue":"12","key":"3387_CR28","doi-asserted-by":"publisher","first-page":"3038","DOI":"10.1084\/jem.20180539","volume":"215","author":"ZH Wang","year":"2018","unstructured":"Wang ZH, Liu P, Liu X, Yu SP, Wang JZ, Ye K (2018) Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies. J Exp Med 215(12):3038\u20133056. https:\/\/doi.org\/10.1084\/jem.20180539","journal-title":"J Exp Med"},{"issue":"17","key":"3387_CR29","doi-asserted-by":"publisher","first-page":"10032","DOI":"10.1073\/pnas.1630428100","volume":"100","author":"TC Gamblin","year":"2003","unstructured":"Gamblin TC, Chen F, Zambrano A et al (2003) Caspase cleavage of tau: linking amyloid and neurofibrillary tangles in Alzheimer\u2019s disease. PNAS 100(17):10032\u201310037. https:\/\/doi.org\/10.1073\/pnas.1630428100","journal-title":"PNAS"},{"issue":"7","key":"3387_CR30","doi-asserted-by":"publisher","first-page":"3521","DOI":"10.3390\/ijms22073521","volume":"22","author":"MG Friedrich","year":"2021","unstructured":"Friedrich MG, Skora A, Hancock SE, Mitchell TW, Else PL, Truscott RJ (2021) Tau is truncated in five regions of the normal adult human brain. Int J Mol Sci 22(7):3521. https:\/\/doi.org\/10.3390\/ijms22073521","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3387_CR31","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.1074\/jbc.REV118.005594","volume":"294","author":"M Stewart","year":"2019","unstructured":"Stewart M (2019) Polyadenylation and nuclear export of mRNAs. J Biol Chem 294(9):2977\u20132987. https:\/\/doi.org\/10.1074\/jbc.REV118.005594","journal-title":"J Biol Chem"},{"key":"3387_CR32","doi-asserted-by":"publisher","first-page":"742790","DOI":"10.3389\/fnmol.2021.742790","volume":"14","author":"M Montalbano","year":"2021","unstructured":"Montalbano M, Jaworski E, Garcia S, Ellsworth A, McAllen S, Routh A, Kayed R (2021) Tau modulates mrna transcription, alternative polyadenylation profiles of hnRNPs, chromatin remodeling and spliceosome complexes. Front Mol Neurosci 14:742790. https:\/\/doi.org\/10.3389\/fnmol.2021.742790","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"3387_CR33","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s40478-016-0345-0","volume":"4","author":"A Papegaey","year":"2016","unstructured":"Papegaey A, Eddarkaoui S, Deramecourt V et al (2016) Reduced Tau protein expression is associated with frontotemporal degeneration with progranulin mutation. Acta Neuropathol Commun 4(1):74. https:\/\/doi.org\/10.1186\/s40478-016-0345-0","journal-title":"Acta Neuropathol Commun"},{"issue":"3","key":"3387_CR34","doi-asserted-by":"publisher","first-page":"574","DOI":"10.1007\/s12031-011-9622-3","volume":"45","author":"ME Ward","year":"2011","unstructured":"Ward ME, Miller BL (2011) Potential mechanisms of progranulin-deficient FTLD. J Mol Neurosci 45(3):574\u2013582. https:\/\/doi.org\/10.1007\/s12031-011-9622-3","journal-title":"J Mol Neurosci"},{"issue":"4","key":"3387_CR35","doi-asserted-by":"publisher","first-page":"e0195771","DOI":"10.1371\/journal.pone.0195771","volume":"13","author":"MM Hefti","year":"2018","unstructured":"Hefti MM, Farrell K, Kim S, Bowles KR, Fowkes ME, Raj T, Crary JF (2018) High-resolution temporal and regional mapping of MAPT expression and splicing in human brain development. PloS one 13(4):e0195771. https:\/\/doi.org\/10.1371\/journal.pone.0195771","journal-title":"PloS one"},{"key":"3387_CR36","doi-asserted-by":"publisher","first-page":"643115","DOI":"10.3389\/fnins.2021.643115","volume":"15","author":"S Bachmann","year":"2021","unstructured":"Bachmann S, Bell M, Klimek J, Zempel H (2021) Differential effects of the six human TAU isoforms: Somatic retention of 2N-TAU and increased microtubule number induced by 4R-TAU. Front Neurosci 15:643115. https:\/\/doi.org\/10.3389\/fnins.2021.643115","journal-title":"Front Neurosci"},{"key":"3387_CR37","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.sbi.2020.05.011","volume":"64","author":"SH Scheres","year":"2020","unstructured":"Scheres SH, Zhang W, Falcon B, Goedert M (2020) Cryo-EM structures of tau filaments. Curr Opin Struct Biol 64:17\u201325. https:\/\/doi.org\/10.1016\/j.sbi.2020.05.011","journal-title":"Curr Opin Struct Biol"},{"issue":"7662","key":"3387_CR38","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1038\/nature23002","volume":"547","author":"AW Fitzpatrick","year":"2017","unstructured":"Fitzpatrick AW, Falcon B, He S et al (2017) Cryo-EM structures of tau filaments from Alzheimer\u2019s disease. Nature 547(7662):185\u2013190. https:\/\/doi.org\/10.1038\/nature23002","journal-title":"Nature"},{"issue":"18","key":"3387_CR39","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1093\/hmg\/dds238","volume":"21","author":"D Trabzuni","year":"2012","unstructured":"Trabzuni D, Wray S, Vandrovcova J, Ramasamy A, Walker R, Smith C, Ryten M (2012) MAPT expression and splicing is differentially regulated by brain region: relation to genotype and implication for tauopathies. Hum Mol Genet 21(18):4094\u20134103. https:\/\/doi.org\/10.1093\/hmg\/dds238","journal-title":"Hum Mol Genet"},{"issue":"1","key":"3387_CR40","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1515\/revneuro-2020-0152","volume":"33","author":"M Bell","year":"2022","unstructured":"Bell M, Zempel H (2022) SH-SY5Y-derived neurons: a human neuronal model system for investigating TAU sorting and neuronal subtype-specific TAU vulnerability. Rev Neurosci 33(1):1\u201315. https:\/\/doi.org\/10.1515\/revneuro-2020-0152","journal-title":"Rev Neurosci"},{"key":"3387_CR41","doi-asserted-by":"publisher","unstructured":"Li L, Xu ZP, Liu GP, Xu C, Wang ZH, Li XG, Wang JZ (2015) Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells. PLoS One 10(3). https:\/\/doi.org\/10.1371\/journal.pone.0119865","DOI":"10.1371\/journal.pone.0119865"},{"issue":"2","key":"3387_CR42","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.jneumeth.2011.08.037","volume":"203","author":"C Sinadinos","year":"2012","unstructured":"Sinadinos C, Cowan CM, Wyttenbach A, Mudher A (2012) Increased throughput assays of locomotor dysfunction in Drosophila larvae. J Neurosci Methods 203(2):325\u2013334. https:\/\/doi.org\/10.1016\/j.jneumeth.2011.08.037","journal-title":"J Neurosci Methods"},{"key":"3387_CR43","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.nbd.2017.05.003","volume":"105","author":"MA Sealey","year":"2017","unstructured":"Sealey MA, Vourkou E, Cowan CM, Bossing T, Quraishe S, Grammenoudi S, Mudher A (2017) Distinct phenotypes of three-repeat and four-repeat human tau in a transgenic model of tauopathy. Neurobiol Dis 105:74\u201383. https:\/\/doi.org\/10.1016\/j.nbd.2017.05.003","journal-title":"Neurobiol Dis"},{"issue":"4","key":"3387_CR44","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/1096-9861(20001225)428:4<630::aid-cne4>3.0.co;2-x","volume":"428","author":"DW Williams","year":"2000","unstructured":"Williams DW, Tyrer M, Shepherd D (2000) Tau and tau reporters disrupt central projections of sensory neurons in Drosophila. J Comp Neurol 428(4):630\u2013640. https:\/\/doi.org\/10.1002\/1096-9861(20001225)428:4%3c630::aid-cne4%3e3.0.co;2-x","journal-title":"J Comp Neurol"},{"issue":"5","key":"3387_CR45","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/s0092-8674(04)00170-9","volume":"116","author":"I Nishimura","year":"2004","unstructured":"Nishimura I, Yang Y, Lu B (2004) PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell 116(5):671\u2013682. https:\/\/doi.org\/10.1016\/s0092-8674(04)00170-9","journal-title":"Cell"},{"issue":"3","key":"3387_CR46","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1111\/jnc.14940","volume":"154","author":"K Pampuscenko","year":"2020","unstructured":"Pampuscenko K, Morkuniene R, Sneideris T, Smirnovas V, Budvytyte R, Valincius G, Borutaite V (2020) Extracellular tau induces microglial phagocytosis of living neurons in cell cultures. J Neurochem 154(3):316\u2013329. https:\/\/doi.org\/10.1111\/jnc.14940","journal-title":"J Neurochem"},{"issue":"2","key":"3387_CR47","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1007\/s12035-020-02150-7","volume":"58","author":"K Pampuscenko","year":"2021","unstructured":"Pampuscenko K, Morkuniene R, Krasauskas L, Smirnovas V, Tomita T, Borutaite V (2021) Distinct neurotoxic effects of extracellular tau species in primary neuronal-glial cultures. Mol Neurobiol 58(2):658\u2013667. https:\/\/doi.org\/10.1007\/s12035-020-02150-7","journal-title":"Mol Neurobiol"},{"issue":"5","key":"3387_CR48","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1016\/j.jagp.2014.10.005","volume":"23","author":"L Mah","year":"2015","unstructured":"Mah L, Binns MA, Steffens DC (2015) Alzheimer\u2019s Disease Neuroimaging Initiative Anxiety symptoms in amnestic mild cognitive impairment are associated with medial temporal atrophy and predict conversion to Alzheimer disease. Am J Geriatr. Psychiatry 23(5):466\u2013476. https:\/\/doi.org\/10.1016\/j.jagp.2014.10.005","journal-title":"Am J Geriatr. Psychiatry"},{"issue":"5","key":"3387_CR49","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1176\/appi.ajp.2014.13060821","volume":"171","author":"YE Geda","year":"2014","unstructured":"Geda YE, Roberts RO, Mielke MM, Knopman DS, Christianson TJ, Pankratz VS, Rocca WA (2014) Baseline neuropsychiatric symptoms and the risk of incident mild cognitive impairment: a population-based study. Am J Psychiatry 171(5):572\u2013581. https:\/\/doi.org\/10.1176\/appi.ajp.2014.13060821","journal-title":"Am J Psychiatry"},{"issue":"8","key":"3387_CR50","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1084\/jem.20161731","volume":"214","author":"E Marciniak","year":"2017","unstructured":"Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Blum D (2017) Tau deletion promotes brain insulin resistance. J Exp Med 214(8):2257\u20132269. https:\/\/doi.org\/10.1084\/jem.20161731","journal-title":"J Exp Med"},{"issue":"6","key":"3387_CR51","doi-asserted-by":"publisher","first-page":"3166","DOI":"10.1096\/fj.201701352","volume":"32","author":"N Wijesekara","year":"2018","unstructured":"Wijesekara N, Goncalves RA, Ahrens R, De Felice FG, Fraser PE (2018) Tau ablation in mice leads to pancreatic cell dysfunction and glucose intolerance. FASEB J 32(6):3166\u20133173. https:\/\/doi.org\/10.1096\/fj.201701352","journal-title":"FASEB J"},{"issue":"1","key":"3387_CR52","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1750-1326-9-29","volume":"9","author":"P Lei","year":"2014","unstructured":"Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI, Bush AI (2014) Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener 9(1):1\u201312. https:\/\/doi.org\/10.1186\/1750-1326-9-29","journal-title":"Mol Neurodegener"},{"key":"3387_CR53","doi-asserted-by":"publisher","unstructured":"Rebolledo-Solleiro D, Roldan-Roldan G, Diaz D, Velasco M, Larque C, Rico-Rosillo G, Perez de la Mora M (2017) Increased anxiety-like behavior is associated with the metabolic syndrome in non-stressed rats. PLoS One 12(5). https:\/\/doi.org\/10.1371\/journal.pone.0176554","DOI":"10.1371\/journal.pone.0176554"},{"key":"3387_CR54","doi-asserted-by":"publisher","first-page":"160","DOI":"10.3389\/fnagi.2015.00160","volume":"7","author":"BT Biallosterski","year":"2015","unstructured":"Biallosterski BT, Prickaerts J, Rahnama\u2019i MS, De Wachter S, Van Koeveringe GA, Meriaux C (2015) Changes in voiding behavior in a mouse model of Alzheimer\u2019s disease. Front Aging Neurosci 7:160. https:\/\/doi.org\/10.3389\/fnagi.2015.00160","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"3387_CR55","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3233\/ADR-210294","volume":"5","author":"MF Mendez","year":"2021","unstructured":"Mendez MF (2021) The relationship between anxiety and Alzheimer\u2019s disease. J Alzheimers Dis Rep 5(1):171\u2013177. https:\/\/doi.org\/10.3233\/ADR-210294","journal-title":"J Alzheimers Dis Rep"},{"key":"3387_CR56","doi-asserted-by":"publisher","first-page":"124","DOI":"10.3389\/fendo.2020.00124","volume":"11","author":"RA Gon\u00dfalves","year":"2020","unstructured":"Gon\u00dfalves RA, Wijesekara N, Fraser PE, De Felice FG (2020) Behavioral abnormalities in knockout and humanized tau mice. Front endocrinol 11:124. https:\/\/doi.org\/10.3389\/fendo.2020.00124","journal-title":"Front endocrinol"},{"key":"3387_CR57","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s40478-015-0210-6","volume":"3","author":"JM Wheeler","year":"2015","unstructured":"Wheeler JM, McMillan PJ, Hawk M (2015) High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta Neuropathol Commun 3:33. https:\/\/doi.org\/10.1186\/s40478-015-0210-6","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"3387_CR58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12974-020-01749-w","volume":"17","author":"Y Sun","year":"2020","unstructured":"Sun Y, Guo Y, Feng X, Jia M, Ai N, Dong Y, Kong W (2020) The behavioral and neuropathologic sexual dimorphism and absence of MIP-3 in tau P301S mouse model of Alzheimer\u2019s disease. J Neuroinflammation 17(1):1\u201318. https:\/\/doi.org\/10.1186\/s12974-020-01749-w","journal-title":"J Neuroinflammation"},{"issue":"4","key":"3387_CR59","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s00401-017-1722-x","volume":"134","author":"WP Flavin","year":"2017","unstructured":"Flavin WP, Bousset L, Green ZC, Chu Y, Skarpathiotis S, Chaney MJ, Campbell EM (2017) Endocytic vesicle rupture is a conserved mechanism of cellular invasion by amyloid proteins. Acta Neuropathol 134(4):629\u2013653. https:\/\/doi.org\/10.1007\/s00401-017-1722-x","journal-title":"Acta Neuropathol"},{"key":"3387_CR60","doi-asserted-by":"publisher","unstructured":"Wu L, Wang Z, Ladd S, Dougharty DT, Madhavan SS, Marcus M, Xu B (2020) Human tau isoform aggregation and selective detection of misfolded tau from post-mortem Alzheimer\u2019s disease brains. bioRxiv, 2019\u201312. https:\/\/doi.org\/10.1101\/2019.12.31.876946","DOI":"10.1101\/2019.12.31.876946"},{"issue":"1","key":"3387_CR61","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1080\/19336896.2020.1832946","volume":"14","author":"JM Tennant","year":"2020","unstructured":"Tennant JM, Henderson DM, Wisniewski TM, Hoover EA (2020) RT-QuIC detection of tauopathies using full-length tau substrates. Prion 14(1):249\u2013256. https:\/\/doi.org\/10.1080\/19336896.2020.1832946","journal-title":"Prion"},{"issue":"9","key":"3387_CR62","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1093\/jnen\/nlab073","volume":"80","author":"SH Kim","year":"2021","unstructured":"Kim SH, Farrell K, Cosentino S et al (2021) Tau isoform profile in essential tremor diverges from other tauopathies. J Neuropathol Exp 80(9):835\u2013843. https:\/\/doi.org\/10.1093\/jnen\/nlab073","journal-title":"J Neuropathol Exp"},{"issue":"6","key":"3387_CR63","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1007\/s00702-004-0221-0","volume":"112","author":"CX Gong","year":"2005","unstructured":"Gong CX, Liu F, Grundke-Iqbal I, Iqbal K (2005) Post-translational modifications of tau protein in Alzheimer\u2019s disease. J Neural Transm 112(6):813\u2013838. https:\/\/doi.org\/10.1007\/s00702-004-0221-0","journal-title":"J Neural Transm"},{"issue":"1","key":"3387_CR64","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E (2016) Tau in physiology and pathology. Nat Rev Neurosci 17(1):22\u201335. https:\/\/doi.org\/10.1038\/nrn.2015.1","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"3387_CR65","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1016\/j.cell.2020.10.029","volume":"183","author":"H Wesseling","year":"2020","unstructured":"Wesseling H, Mair W, Kumar M et al (2020) Tau PTM profiles identify patient heterogeneity and stages of Alzheimer\u2019s disease. Cell 183(6):1699\u20131713. https:\/\/doi.org\/10.1016\/j.cell.2020.10.029","journal-title":"Cell"},{"key":"3387_CR66","doi-asserted-by":"publisher","unstructured":"Boxer AL, Polydoro M (2020) Targeting tau: clinical trials and novel therapeutic approaches. Neurosci Lett 731. https:\/\/doi.org\/10.1016\/j.neulet.2020.134919","DOI":"10.1016\/j.neulet.2020.134919"},{"issue":"6","key":"3387_CR67","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/j.neuron.2010.08.044","volume":"67","author":"SH Cho","year":"2010","unstructured":"Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW, Gan L (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67(6):953\u2013966. https:\/\/doi.org\/10.1016\/j.neuron.2010.08.044","journal-title":"Neuron"},{"issue":"1","key":"3387_CR68","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/ncomms1255","volume":"2","author":"TJ Cohen","year":"2011","unstructured":"Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2(1):1\u20139. https:\/\/doi.org\/10.1038\/ncomms1255","journal-title":"Nat Commun"},{"issue":"11","key":"3387_CR69","doi-asserted-by":"publisher","first-page":"5066","DOI":"10.1073\/pnas.90.11.5066","volume":"90","author":"M Goedert","year":"1993","unstructured":"Goedert M, Jakes R, Crowther RA, Six J, Lbke U, Vandermeeren M, Lee VM (1993) The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development. PNAS 90(11):5066\u20135070. https:\/\/doi.org\/10.1073\/pnas.90.11.5066","journal-title":"PNAS"},{"issue":"2","key":"3387_CR70","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1523\/JNEUROSCI.1490-09.2010","volume":"30","author":"S Kosmidis","year":"2010","unstructured":"Kosmidis S, Grammenoudi S, Papanikolopoulou K, Skoulakis EM (2010) Differential effects of Tau on the integrity and function of neurons essential for learning in Drosophila. J Neurosci 30(2):464\u2013477. https:\/\/doi.org\/10.1523\/JNEUROSCI.1490-09.2010","journal-title":"J Neurosci"},{"key":"3387_CR71","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3389\/fnagi.2019.00256","volume":"11","author":"NI Trushina","year":"2019","unstructured":"Trushina NI, Bakota L, Mulkidjanian AY, Brandt R (2019) The evolution of tau phosphorylation and interactions. Front Aging Neurosci 11:256. https:\/\/doi.org\/10.3389\/fnagi.2019.00256","journal-title":"Front Aging Neurosci"},{"issue":"6","key":"3387_CR72","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1021\/acs.biochem.8b01039","volume":"58","author":"Y Mutreja","year":"2019","unstructured":"Mutreja Y, Combs B, Gamblin TC (2019) FTDP-17 mutations alter the aggregation and microtubule stabilization propensity of tau in an isoform-specific fashion. Biochemistry 58(6):742\u2013754. https:\/\/doi.org\/10.1021\/acs.biochem.8b01039","journal-title":"Biochemistry"},{"issue":"4","key":"3387_CR73","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/prot.24988","volume":"84","author":"TJ Malia","year":"2016","unstructured":"Malia TJ, Teplyakov A, Ernst R, Wu SJ, Lacy ER, Liu X, Gilliland GL (2016) Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti, \u00c4\u00eatau antibody AT8. Proteins 84(4):427\u2013434. https:\/\/doi.org\/10.1002\/prot.24988","journal-title":"Proteins"},{"issue":"3","key":"3387_CR74","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.bbadis.2003.09.001","volume":"1639","author":"H Ksiezak-Reding","year":"2003","unstructured":"Ksiezak-Reding H, Pyo HK, Feinstein B, Pasinetti GM (2003) Akt\/PKB kinase phosphorylates separately Thr212 and Ser214 of tau protein in vitro. Biochim Biophys Acta - Mol Basis Dis. 1639(3):159\u2013168. https:\/\/doi.org\/10.1016\/j.bbadis.2003.09.001","journal-title":"Biochim Biophys Acta - Mol Basis Dis."},{"key":"3387_CR75","doi-asserted-by":"publisher","unstructured":"Ferrer I, Barrachina M, Puig B (2002) Anti-tau phospho-specific Ser 262 antibody recognizes a variety of abnormal hyper-phosphorylated tau deposits in tauopathies including Pick bodies and argyrophilic grains. Acta neuropathol 104(6). https:\/\/doi.org\/10.1007\/s00401-002-0600-2","DOI":"10.1007\/s00401-002-0600-2"},{"key":"3387_CR76","doi-asserted-by":"publisher","DOI":"10.4061\/2011\/428970","author":"A De Vos","year":"2011","unstructured":"De Vos A, Anandhakumar J, Van den Brande J, Verduyckt M, Franssens V, Winderickx J, Swinnen E (2011) Yeast as a model system to study tau biology. J Alzheimer\u2019s Dis. https:\/\/doi.org\/10.4061\/2011\/428970","journal-title":"J Alzheimer\u2019s Dis"},{"issue":"5","key":"3387_CR77","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1038\/cdd.2009.203","volume":"17","author":"V Franssens","year":"2010","unstructured":"Franssens V, Boelen E, Anandhakumar J, Vanhelmont T, B\u00fcttner S, Winderickx J (2010) Yeast unfolds the road map toward alpha-synuclein-induced cell death. Cell Death Differ. 17(5):746\u2013753. https:\/\/doi.org\/10.1038\/cdd.2009.203","journal-title":"Cell Death Differ."},{"issue":"34","key":"3387_CR78","doi-asserted-by":"publisher","first-page":"11466","DOI":"10.1021\/bi0506775","volume":"44","author":"T Vandebroek","year":"2005","unstructured":"Vandebroek T, Vanhelmont T, Terwel D, Borghgraef P, Lemaire K, Snauwaert J, Winderickx J (2005) Identification and isolation of a hyperphosphorylated, conformationally changed intermediate of human protein tau expressed in yeast. Biochemistry 44(34):11466\u201311475. https:\/\/doi.org\/10.1021\/bi0506775","journal-title":"Biochemistry"},{"key":"3387_CR79","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbadis.2015.12.002","volume":"2","author":"K Liu","year":"1862","unstructured":"Liu K, Liu Y, Li L, Qin P, Iqbal J, Deng Y (1862) Qing H (2016) Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property. Biochim Biophys Acta Mol Basis Dis 2:192\u2013201. https:\/\/doi.org\/10.1016\/j.bbadis.2015.12.002","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"issue":"1","key":"3387_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/srep44102","volume":"7","author":"H Trzeciakiewicz","year":"2017","unstructured":"Trzeciakiewicz H, Tseng JH, Wander CM, Madden V, Tripathy A, Yuan CX, Cohen TJ (2017) A dual pathogenic mechanism links tau acetylation to sporadic tauopathy. Sci Rep 7(1):1\u201313. https:\/\/doi.org\/10.1038\/srep44102","journal-title":"Sci Rep"},{"key":"3387_CR81","doi-asserted-by":"publisher","unstructured":"Cohen TJ, Constance BH, Hwang AW, James M, Yuan CX (2016) Intrinsic tau acetylation is coupled to auto-proteolytic tau fragmentation. PloS one 11(7). https:\/\/doi.org\/10.1371\/journal.pone.0158470","DOI":"10.1371\/journal.pone.0158470"},{"issue":"3","key":"3387_CR82","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1093\/brain\/aws013","volume":"135","author":"DJ Irwin","year":"2012","unstructured":"Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VMY, Trojanowski JQ (2012) Acetylated tau, a novel pathological signature in Alzheimer\u2019s disease and other tauopathies. Brain 135(3):807\u2013818. https:\/\/doi.org\/10.1093\/brain\/aws013","journal-title":"Brain"},{"issue":"12","key":"3387_CR83","doi-asserted-by":"publisher","first-page":"4400","DOI":"10.3390\/ijms21124400","volume":"21","author":"F Munari","year":"2020","unstructured":"Munari F, Barracchia CG, Parolini F, Tira R, Bubacco L, Assfalg M, D\u2019Onofrio M (2020) Semisynthetic modification of tau protein with di-ubiquitin chains for aggregation studies. Int J Mol Sci 21(12):4400. https:\/\/doi.org\/10.3390\/ijms21124400","journal-title":"Int J Mol Sci"},{"issue":"19","key":"3387_CR84","doi-asserted-by":"publisher","first-page":"11527","DOI":"10.3390\/ijms231911527","volume":"23","author":"J Sala-Jarque","year":"2022","unstructured":"Sala-Jarque J, Zimkowska K, \u00c5vila J, Ferrer I, Del Rio JA (2022) Towards a mechanistic model of tau-mediated pathology in tauopathies: what can we learn from cell-based in vitro assays? Int J Mol Sci 23(19):11527. https:\/\/doi.org\/10.3390\/ijms231911527","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3387_CR85","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1016\/j.stemcr.2022.07.011","volume":"17","author":"SM Glasauer","year":"2022","unstructured":"Glasauer SM, Goderie SK, Rauch JN et al (2022) Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol. Stem Cell Rep 17(9):2127\u20132140. https:\/\/doi.org\/10.1016\/j.stemcr.2022.07.011","journal-title":"Stem Cell Rep"},{"issue":"9","key":"3387_CR86","doi-asserted-by":"publisher","first-page":"100289","DOI":"10.1016\/j.crmeth.2022.100289","volume":"2","author":"H Shimada","year":"2022","unstructured":"Shimada H, Sato Y, Sasaki T, Shimozawa A et al (2022) A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer. Cell Rep Methods 2(9):100289. https:\/\/doi.org\/10.1016\/j.crmeth.2022.100289","journal-title":"Cell Rep Methods"},{"issue":"3","key":"3387_CR87","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.3390\/ijms22031085","volume":"22","author":"A Noor","year":"2021","unstructured":"Noor A, Zafar S, Zerr I (2021) Neurodegenerative proteinopathies in the proteoform spectrum-tools and challenges. Int J Mol Sci 22(3):1085. https:\/\/doi.org\/10.3390\/ijms22031085","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03387-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03387-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03387-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T09:35:08Z","timestamp":1691660108000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03387-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":87,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["3387"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03387-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,2]]},"assertion":[{"value":"12 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval and Consent to Participate"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}