{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:18Z","timestamp":1772119998628,"version":"3.50.1"},"reference-count":108,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1007\/s12035-023-03556-9","type":"journal-article","created":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T11:02:18Z","timestamp":1692270138000},"page":"120-131","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Higher Neuronal Facilitation and Potentiation with APOE4 Suppressed by Angiotensin II"],"prefix":"10.1007","volume":"61","author":[{"given":"Sarah B.","family":"Scheinman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuei Y.","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Alford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-6717","authenticated-orcid":false,"given":"Leon M.","family":"Tai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"3556_CR1","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s disease facts and figures (2022) Alzheimers Dement. 18(4):700\u2013789","DOI":"10.1002\/alz.12638"},{"issue":"2","key":"3556_CR2","first-page":"e105","volume":"7","author":"Collaborators, G.B.D.D.F","year":"2022","unstructured":"Collaborators, G.B.D.D.F (2022) Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. Lancet. Public Health 7(2):e105\u2013e125","journal-title":"Public Health"},{"key":"3556_CR3","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.neuroscience.2015.03.006","volume":"309","author":"EJ Mufson","year":"2015","unstructured":"Mufson EJ et al (2015) Hippocampal plasticity during the progression of Alzheimer\u2019s disease. Neuroscience 309:51\u201367","journal-title":"Neuroscience"},{"issue":"4","key":"3556_CR4","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1590\/1806-9282.66.4.512","volume":"66","author":"JVL Balestrieri","year":"1992","unstructured":"Balestrieri JVL et al (1992) Structural volume of hippocampus and Alzheimer\u2019s disease. Rev Assoc Med Bras 66(4):512\u2013515","journal-title":"Rev Assoc Med Bras"},{"issue":"3","key":"3556_CR5","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00401-022-02526-0","volume":"145","author":"P Scaduto","year":"2023","unstructured":"Scaduto P et al (2023) Functional excitatory to inhibitory synaptic imbalance and loss of cognitive performance in people with Alzheimer\u2019s disease neuropathologic change. Acta Neuropathol 145(3):303\u2013324","journal-title":"Acta Neuropathol"},{"issue":"2","key":"3556_CR6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","volume":"9","author":"CC Liu","year":"2013","unstructured":"Liu CC et al (2013) Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy. Nat Rev Neurol 9(2):106\u2013118","journal-title":"Nat Rev Neurol"},{"issue":"1","key":"3556_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1097\/MOL.0000000000000383","volume":"28","author":"F Liao","year":"2017","unstructured":"Liao F, Yoon H, Kim J (2017) Apolipoprotein E metabolism and functions in brain and its role in Alzheimer\u2019s disease. Curr Opin Lipidol 28(1):60\u201367","journal-title":"Curr Opin Lipidol"},{"issue":"8","key":"3556_CR8","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1212\/WNL.0000000000000154","volume":"82","author":"GA Kerchner","year":"2014","unstructured":"Kerchner GA et al (2014) APOE epsilon4 worsens hippocampal CA1 apical neuropil atrophy and episodic memory. Neurology 82(8):691\u2013697","journal-title":"Neurology"},{"issue":"6","key":"3556_CR9","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1002\/hipo.20614","volume":"19","author":"SG Mueller","year":"2009","unstructured":"Mueller SG, Weiner MW (2009) Selective effect of age, Apo e4, and Alzheimer\u2019s disease on hippocampal subfields. Hippocampus 19(6):558\u2013564","journal-title":"Hippocampus"},{"issue":"22","key":"3556_CR10","doi-asserted-by":"publisher","first-page":"10256","DOI":"10.1073\/pnas.1001412107","volume":"107","author":"DA Wolk","year":"2010","unstructured":"Wolk DA, Dickerson BC, I. Alzheimer\u2019s Disease Neuroimaging (2010) Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 107(22):10256\u201310261","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"17","key":"3556_CR11","doi-asserted-by":"publisher","first-page":"2655","DOI":"10.1097\/00001756-200412030-00020","volume":"15","author":"BL Trommer","year":"2004","unstructured":"Trommer BL et al (2004) ApoE isoform affects LTP in human targeted replacement mice. Neuroreport 15(17):2655\u20132658","journal-title":"Neuroreport"},{"issue":"9","key":"3556_CR12","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1194\/jlr.R076315","volume":"58","author":"LM Tai","year":"2017","unstructured":"Tai LM et al (2017) EFAD transgenic mice as a human APOE relevant preclinical model of Alzheimer\u2019s disease. J Lipid Res 58(9):1733\u20131755","journal-title":"J Lipid Res"},{"key":"3556_CR13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13024-015-0002-2","volume":"10","author":"DS Liu","year":"2015","unstructured":"Liu DS et al (2015) APOE4 enhances age-dependent decline in cognitive function by down-regulating an NMDA receptor pathway in EFAD-Tg mice. Mol Neurodegener 10:7","journal-title":"Mol Neurodegener"},{"issue":"6","key":"3556_CR14","doi-asserted-by":"publisher","first-page":"1667","DOI":"10.1016\/j.neuropsychologia.2007.11.035","volume":"46","author":"MA Trivedi","year":"2008","unstructured":"Trivedi MA et al (2008) fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: risk factors for Alzheimer\u2019s disease. Neuropsychologia 46(6):1667\u20131678","journal-title":"Neuropsychologia"},{"issue":"7","key":"3556_CR15","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1056\/NEJM200008173430701","volume":"343","author":"SY Bookheimer","year":"2000","unstructured":"Bookheimer SY et al (2000) Patterns of brain activation in people at risk for Alzheimer\u2019s disease. N Engl J Med 343(7):450\u2013456","journal-title":"N Engl J Med"},{"issue":"17","key":"3556_CR16","doi-asserted-by":"publisher","first-page":"7209","DOI":"10.1073\/pnas.0811879106","volume":"106","author":"N Filippini","year":"2009","unstructured":"Filippini N et al (2009) Distinct patterns of brain activity in young carriers of the APOE-epsilon4 allele. Proc Natl Acad Sci U S A 106(17):7209\u20137214","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6259","key":"3556_CR17","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1126\/science.aac8128","volume":"350","author":"L Kunz","year":"2015","unstructured":"Kunz L et al (2015) Reduced grid-cell-like representations in adults at genetic risk for Alzheimer\u2019s disease. Science 350(6259):430\u2013433","journal-title":"Science"},{"issue":"22","key":"3556_CR18","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1073\/pnas.1206171109","volume":"109","author":"MA Busche","year":"2012","unstructured":"Busche MA et al (2012) Critical role of soluble amyloid-beta for early hippocampal hyperactivity in a mouse model of Alzheimer\u2019s disease. Proc Natl Acad Sci U S A 109(22):8740\u20138745","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"3556_CR19","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","volume":"45","author":"LM Billings","year":"2005","unstructured":"Billings LM et al (2005) Intraneuronal Abeta causes the onset of early Alzheimer\u2019s disease-related cognitive deficits in transgenic mice. Neuron 45(5):675\u2013688","journal-title":"Neuron"},{"key":"3556_CR20","doi-asserted-by":"publisher","first-page":"266","DOI":"10.3389\/fnins.2020.00266","volume":"14","author":"Y Vyas","year":"2020","unstructured":"Vyas Y, Montgomery JM, Cheyne JE (2020) Hippocampal deficits in amyloid-beta-related rodent models of Alzheimer\u2019s disease. Front Neurosci 14:266","journal-title":"Front Neurosci"},{"issue":"1","key":"3556_CR21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.nbd.2004.08.011","volume":"18","author":"BL Trommer","year":"2005","unstructured":"Trommer BL et al (2005) ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. Neurobiol Dis 18(1):75\u201382","journal-title":"Neurobiol Dis"},{"issue":"3","key":"3556_CR22","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/j.neulet.2004.07.084","volume":"369","author":"HW Kitamura","year":"2004","unstructured":"Kitamura HW et al (2004) Age-dependent enhancement of hippocampal long-term potentiation in knock-in mice expressing human apolipoprotein E4 instead of mouse apolipoprotein E. Neurosci Lett 369(3):173\u2013178","journal-title":"Neurosci Lett"},{"key":"3556_CR23","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1750-1326-4-21","volume":"4","author":"KM Korwek","year":"2009","unstructured":"Korwek KM et al (2009) ApoE isoform-dependent changes in hippocampal synaptic function. Mol Neurodegener 4:21","journal-title":"Mol Neurodegener"},{"issue":"26","key":"3556_CR24","doi-asserted-by":"publisher","first-page":"12011","DOI":"10.1073\/pnas.0914984107","volume":"107","author":"Y Chen","year":"2010","unstructured":"Chen Y et al (2010) ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling. Proc Natl Acad Sci U S A 107(26):12011\u201312016","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"3556_CR25","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3233\/JAD-190474","volume":"71","author":"MJ Lennon","year":"2019","unstructured":"Lennon MJ et al (2019) Midlife hypertension and Alzheimer\u2019s disease: a systematic review and meta-analysis. J Alzheimers Dis 71(1):307\u2013316","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"3556_CR26","first-page":"415","volume":"52","author":"M de Gasparo","year":"2000","unstructured":"de Gasparo M et al (2000) International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol Rev 52(3):415\u2013472","journal-title":"Pharmacol Rev"},{"issue":"1","key":"3556_CR27","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1186\/s13195-016-0217-7","volume":"8","author":"PG Kehoe","year":"2016","unstructured":"Kehoe PG et al (2016) Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-beta and tau pathology. Alzheimers Res Ther 8(1):50","journal-title":"Alzheimers Res Ther"},{"issue":"4","key":"3556_CR28","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1093\/gerona\/glab376","volume":"77","author":"C Cosarderelioglu","year":"2022","unstructured":"Cosarderelioglu C et al (2022) Higher angiotensin II type 1 receptor levels and activity in the postmortem brains of older persons with Alzheimer\u2019s dementia. J Gerontol A Biol Sci Med Sci 77(4):664\u2013672","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"4","key":"3556_CR29","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.3233\/JAD-215051","volume":"84","author":"S Ismael","year":"2021","unstructured":"Ismael S et al (2021) Renin-angiotensin system alterations in the human Alzheimer\u2019s disease brain. J Alzheimers Dis 84(4):1473\u20131484","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"3556_CR30","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0197-4580(00)00259-1","volume":"22","author":"E Savaskan","year":"2001","unstructured":"Savaskan E et al (2001) Cortical alterations of angiotensin converting enzyme, angiotensin II and AT1 receptor in Alzheimer\u2019s dementia. Neurobiol Aging 22(4):541\u2013546","journal-title":"Neurobiol Aging"},{"issue":"3","key":"3556_CR31","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bbrc.2008.08.032","volume":"375","author":"M Mogi","year":"2008","unstructured":"Mogi M et al (2008) Telmisartan prevented cognitive decline partly due to PPAR-gamma activation. Biochem Biophys Res Commun 375(3):446\u2013449","journal-title":"Biochem Biophys Res Commun"},{"key":"3556_CR32","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.nbd.2014.04.018","volume":"68","author":"B Ongali","year":"2014","unstructured":"Ongali B et al (2014) Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer\u2019s disease model. Neurobiol Dis 68:126\u2013136","journal-title":"Neurobiol Dis"},{"key":"3556_CR33","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1016\/j.bbi.2017.04.001","volume":"64","author":"N Torika","year":"2017","unstructured":"Torika N et al (2017) Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer\u2019s disease mice. Brain Behav Immun 64:80\u201390","journal-title":"Brain Behav Immun"},{"issue":"Pt A","key":"3556_CR34","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.phrs.2017.06.017","volume":"125","author":"JM Saavedra","year":"2017","unstructured":"Saavedra JM (2017) Beneficial effects of angiotensin II receptor blockers in brain disorders. Pharmacol Res 125(Pt A):91\u2013103","journal-title":"Pharmacol Res"},{"issue":"5","key":"3556_CR35","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1007\/s10571-011-9754-6","volume":"32","author":"JM Saavedra","year":"2012","unstructured":"Saavedra JM (2012) Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders. Cell Mol Neurobiol 32(5):667\u2013681","journal-title":"Cell Mol Neurobiol"},{"key":"3556_CR36","doi-asserted-by":"publisher","first-page":"628403","DOI":"10.3389\/fnins.2021.628403","volume":"15","author":"SB Scheinman","year":"2021","unstructured":"Scheinman SB et al (2021) Systemic candesartan treatment modulates behavior, synaptic protein levels, and neuroinflammation in female mice that express human APOE4. Front Neurosci 15:628403","journal-title":"Front Neurosci"},{"issue":"4","key":"3556_CR37","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3233\/JAD-2011-110347","volume":"26","author":"NM Davies","year":"2011","unstructured":"Davies NM et al (2011) Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias. J Alzheimers Dis 26(4):699\u2013708","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"3556_CR38","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s10571-015-0327-y","volume":"36","author":"JM Saavedra","year":"2016","unstructured":"Saavedra JM (2016) Evidence to consider angiotensin II receptor blockers for the treatment of early Alzheimer\u2019s disease. Cell Mol Neurobiol 36(2):259\u2013279","journal-title":"Cell Mol Neurobiol"},{"key":"3556_CR39","doi-asserted-by":"crossref","unstructured":"Loera-Valencia R et al (2021) Brain renin-angiotensin system as novel and potential therapeutic target for Alzheimer\u2019s disease. Int J Mol Sci 22(18)","DOI":"10.3390\/ijms221810139"},{"key":"3556_CR40","doi-asserted-by":"crossref","unstructured":"Singh MR, Vigh J, Amberg GC (2021) Angiotensin-II modulates GABAergic neurotransmission in the mouse substantia nigra. eNeuro 8(2)","DOI":"10.1523\/ENEURO.0090-21.2021"},{"issue":"1","key":"3556_CR41","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/BF02741376","volume":"19","author":"EM Richards","year":"1999","unstructured":"Richards EM et al (1999) Angiotensin II type 1 receptor-modulated signaling pathways in neurons. Mol Neurobiol 19(1):25\u201341","journal-title":"Mol Neurobiol"},{"issue":"5","key":"3556_CR42","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1177\/1073858404264678","volume":"10","author":"HL Pan","year":"2004","unstructured":"Pan HL (2004) Brain angiotensin II and synaptic transmission. Neuroscientist 10(5):422\u2013431","journal-title":"Neuroscientist"},{"issue":"6","key":"3556_CR43","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1017\/S0952523800006969","volume":"11","author":"RD Mooney","year":"1994","unstructured":"Mooney RD, Zhang Y, Rhoades RW (1994) Effects of angiotensin II on visual neurons in the superficial laminae of the hamster\u2019s superior colliculus. Vis Neurosci 11(6):1163\u20131173","journal-title":"Vis Neurosci"},{"issue":"3","key":"3556_CR44","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1124\/jpet.104.082495","volume":"313","author":"DP Li","year":"2005","unstructured":"Li DP, Pan HL (2005) Angiotensin II attenuates synaptic GABA release and excites paraventricular-rostral ventrolateral medulla output neurons. J Pharmacol Exp Ther 313(3):1035\u20131045","journal-title":"J Pharmacol Exp Ther"},{"issue":"12","key":"3556_CR45","doi-asserted-by":"publisher","first-page":"5041","DOI":"10.1523\/JNEUROSCI.23-12-05041.2003","volume":"23","author":"DP Li","year":"2003","unstructured":"Li DP, Chen SR, Pan HL (2003) Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci 23(12):5041\u20135049","journal-title":"J Neurosci"},{"issue":"50","key":"3556_CR46","doi-asserted-by":"publisher","first-page":"41774","DOI":"10.1074\/jbc.M112.407957","volume":"287","author":"KL Youmans","year":"2012","unstructured":"Youmans KL et al (2012) APOE4-specific changes in Abeta accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem 287(50):41774\u201341786","journal-title":"J Biol Chem"},{"issue":"6","key":"3556_CR47","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1523\/JNEUROSCI.0035-21.2021","volume":"42","author":"E Church","year":"2022","unstructured":"Church E et al (2022) Synaptic integration of subquantal neurotransmission by colocalized G protein-coupled receptors in presynaptic terminals. J Neurosci 42(6):980\u20131000","journal-title":"J Neurosci"},{"issue":"5","key":"3556_CR48","doi-asserted-by":"publisher","first-page":"e03919","DOI":"10.1016\/j.heliyon.2020.e03919","volume":"6","author":"S Zaldua","year":"2020","unstructured":"Zaldua S et al (2020) Epidermal growth factor treatment of female mice that express APOE4 at an age of advanced pathology mitigates behavioral and cerebrovascular dysfunction. Heliyon 6(5):e03919","journal-title":"Heliyon"},{"issue":"6305","key":"3556_CR49","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/349156a0","volume":"349","author":"ZI Bashir","year":"1991","unstructured":"Bashir ZI et al (1991) Long-term potentiation of NMDA receptor-mediated synaptic transmission in the hippocampus. Nature 349(6305):156\u2013158","journal-title":"Nature"},{"issue":"5","key":"3556_CR50","doi-asserted-by":"publisher","first-page":"1007","DOI":"10.1016\/S0896-6273(00)80481-X","volume":"20","author":"AJ Cochilla","year":"1998","unstructured":"Cochilla AJ, Alford S (1998) Metabotropic glutamate receptor-mediated control of neurotransmitter release. Neuron 20(5):1007\u20131016","journal-title":"Neuron"},{"issue":"1","key":"3556_CR51","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/0006-8993(94)90209-7","volume":"650","author":"LS Leung","year":"1994","unstructured":"Leung LS, Fu XW (1994) Factors affecting paired-pulse facilitation in hippocampal CA1 neurons in vitro. Brain Res 650(1):75\u201384","journal-title":"Brain Res"},{"issue":"1-2","key":"3556_CR52","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0006-8993(02)03846-5","volume":"962","author":"LA Santschi","year":"2003","unstructured":"Santschi LA, Stanton PK (2003) A paired-pulse facilitation analysis of long-term synaptic depression at excitatory synapses in rat hippocampal CA1 and CA3 regions. Brain Res 962(1-2):78\u201391","journal-title":"Brain Res"},{"issue":"3","key":"3556_CR53","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/j.neuron.2017.02.047","volume":"94","author":"SL Jackman","year":"2017","unstructured":"Jackman SL, Regehr WG (2017) The mechanisms and functions of synaptic facilitation. Neuron 94(3):447\u2013464","journal-title":"Neuron"},{"key":"3556_CR54","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1159\/000356422","volume":"34","author":"B Opitz","year":"2014","unstructured":"Opitz B (2014) Memory function and the hippocampus. Front Neurol Neurosci 34:51\u201359","journal-title":"Front Neurol Neurosci"},{"issue":"1633","key":"3556_CR55","doi-asserted-by":"publisher","first-page":"20130288","DOI":"10.1098\/rstb.2013.0288","volume":"369","author":"T Takeuchi","year":"2014","unstructured":"Takeuchi T, Duszkiewicz AJ, Morris RG (2014) The synaptic plasticity and memory hypothesis: encoding, storage and persistence. Philos Trans R Soc Lond B Biol Sci 369(1633):20130288","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"5302","key":"3556_CR56","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1126\/science.275.5302.969","volume":"275","author":"JX Bao","year":"1997","unstructured":"Bao JX, Kandel ER, Hawkins RD (1997) Involvement of pre- and postsynaptic mechanisms in posttetanic potentiation at Aplysia synapses. Science 275(5302):969\u2013973","journal-title":"Science"},{"issue":"6407","key":"3556_CR57","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/361031a0","volume":"361","author":"TV Bliss","year":"1993","unstructured":"Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31\u201339","journal-title":"Nature"},{"issue":"3","key":"3556_CR58","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1002\/neu.480260309","volume":"26","author":"RB Langdon","year":"1995","unstructured":"Langdon RB, Johnson JW, Barrionuevo G (1995) Posttetanic potentiation and presynaptically induced long-term potentiation at the mossy fiber synapse in rat hippocampus. J Neurobiol 26(3):370\u2013385","journal-title":"J Neurobiol"},{"issue":"4753","key":"3556_CR59","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1126\/science.3010459","volume":"232","author":"BR Sastry","year":"1986","unstructured":"Sastry BR, Goh JW, Auyeung A (1986) Associative induction of posttetanic and long-term potentiation in CA1 neurons of rat hippocampus. Science 232(4753):988\u2013990","journal-title":"Science"},{"key":"3556_CR60","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.nicl.2016.12.002","volume":"13","author":"TT Tran","year":"2017","unstructured":"Tran TT et al (2017) Increased hippocampal activation in ApoE-4 carriers and non-carriers with amnestic mild cognitive impairment. Neuroimage Clin 13:237\u2013245","journal-title":"Neuroimage Clin"},{"issue":"8","key":"3556_CR61","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1001\/archgenpsychiatry.2011.1893","volume":"69","author":"LM Nichols","year":"2012","unstructured":"Nichols LM et al (2012) Interactive effect of apolipoprotein e genotype and age on hippocampal activation during memory processing in healthy adults. Arch Gen Psychiatry 69(8):804\u2013813","journal-title":"Arch Gen Psychiatry"},{"issue":"6","key":"3556_CR62","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1001\/archneur.60.6.818","volume":"60","author":"R Diaz-Arrastia","year":"2003","unstructured":"Diaz-Arrastia R et al (2003) Increased risk of late posttraumatic seizures associated with inheritance of APOE epsilon4 allele. Arch Neurol 60(6):818\u2013822","journal-title":"Arch Neurol"},{"issue":"Pt A","key":"3556_CR63","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.yebeh.2019.06.015","volume":"98","author":"Y Liang","year":"2019","unstructured":"Liang Y et al (2019) Association of apolipoprotein E genotypes with epilepsy risk: a systematic review and meta-analysis. Epilepsy Behav 98(Pt A):27\u201335","journal-title":"Epilepsy Behav"},{"issue":"3","key":"3556_CR64","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/ana.410410317","volume":"41","author":"GK Gouras","year":"1997","unstructured":"Gouras GK et al (1997) Increased apolipoprotein E epsilon 4 in epilepsy with senile plaques. Ann Neurol 41(3):402\u2013404","journal-title":"Ann Neurol"},{"key":"3556_CR65","doi-asserted-by":"publisher","first-page":"656521","DOI":"10.3389\/fcell.2021.656521","volume":"9","author":"L Lamoureux","year":"2021","unstructured":"Lamoureux L et al (2021) APOE4 promotes tonic-clonic seizures, an effect modified by familial Alzheimer\u2019s disease mutations. Front Cell Dev Biol 9:656521","journal-title":"Front Cell Dev Biol"},{"issue":"3","key":"3556_CR66","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1515\/REVNEURO.1998.9.3.169","volume":"9","author":"MA Lynch","year":"1998","unstructured":"Lynch MA (1998) Analysis of the mechanisms underlying the age-related impairment in long-term potentiation in the rat. Rev Neurosci 9(3):169\u2013201","journal-title":"Rev Neurosci"},{"issue":"1432","key":"3556_CR67","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1098\/rstb.2002.1244","volume":"358","author":"CA Barnes","year":"2003","unstructured":"Barnes CA (2003) Long-term potentiation and the ageing brain. Philos Trans R Soc Lond B Biol Sci 358(1432):765\u2013772","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"1","key":"3556_CR68","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1038\/s41467-017-01444-0","volume":"8","author":"T Nuriel","year":"2017","unstructured":"Nuriel T et al (2017) Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer\u2019s disease-like pathology. Nat Commun 8(1):1464","journal-title":"Nat Commun"},{"issue":"9","key":"3556_CR69","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/cns.12720","volume":"23","author":"GZ Sun","year":"2017","unstructured":"Sun GZ et al (2017) Hippocampal synaptic and neural network deficits in young mice carrying the human APOE4 gene. CNS Neurosci Ther 23(9):748\u2013758","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"3556_CR70","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.3233\/JAD-140375","volume":"41","author":"F Qiao","year":"2014","unstructured":"Qiao F et al (2014) Apolipoprotein E4 impairs in vivo hippocampal long-term synaptic plasticity by reducing the phosphorylation of CaMKIIalpha and CREB. J Alzheimers Dis 41(4):1165\u20131176","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"3556_CR71","doi-asserted-by":"publisher","first-page":"799","DOI":"10.3233\/JAD-2011-101839","volume":"24","author":"C Balducci","year":"2011","unstructured":"Balducci C et al (2011) The gamma-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. J Alzheimers Dis 24(4):799\u2013816","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"3556_CR72","doi-asserted-by":"publisher","first-page":"1624","DOI":"10.1172\/JCI22831","volume":"114","author":"B Gong","year":"2004","unstructured":"Gong B et al (2004) Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment. J Clin Invest 114(11):1624\u20131634","journal-title":"J Clin Invest"},{"issue":"9","key":"3556_CR73","doi-asserted-by":"publisher","first-page":"3410","DOI":"10.1073\/pnas.0507313103","volume":"103","author":"EH Chang","year":"2006","unstructured":"Chang EH et al (2006) AMPA receptor downscaling at the onset of Alzheimer\u2019s disease pathology in double knockin mice. Proc Natl Acad Sci U S A 103(9):3410\u20133415","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"3556_CR74","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.nbd.2008.10.006","volume":"33","author":"R Kimura","year":"2009","unstructured":"Kimura R, Ohno M (2009) Impairments in remote memory stabilization precede hippocampal synaptic and cognitive failures in 5XFAD Alzheimer mouse model. Neurobiol Dis 33(2):229\u2013235","journal-title":"Neurobiol Dis"},{"issue":"1","key":"3556_CR75","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1038\/nn.2709","volume":"14","author":"M D\u2019Amelio","year":"2011","unstructured":"D\u2019Amelio M et al (2011) Caspase-3 triggers early synaptic dysfunction in a mouse model of Alzheimer\u2019s disease. Nat Neurosci 14(1):69\u201376","journal-title":"Nat Neurosci"},{"issue":"26","key":"3556_CR76","doi-asserted-by":"publisher","first-page":"8989","DOI":"10.1523\/JNEUROSCI.23-26-08989.2003","volume":"23","author":"JG Richards","year":"2003","unstructured":"Richards JG et al (2003) PS2APP transgenic mice, coexpressing hPS2mut and hAPPswe, show age-related cognitive deficits associated with discrete brain amyloid deposition and inflammation. J Neurosci 23(26):8989\u20139003","journal-title":"J Neurosci"},{"issue":"5","key":"3556_CR77","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","volume":"55","author":"JJ Palop","year":"2007","unstructured":"Palop JJ et al (2007) Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer\u2019s disease. Neuron 55(5):697\u2013711","journal-title":"Neuron"},{"key":"3556_CR78","doi-asserted-by":"publisher","first-page":"778","DOI":"10.3389\/fphar.2019.00778","volume":"10","author":"D Mango","year":"2019","unstructured":"Mango D et al (2019) Targeting synaptic plasticity in experimental models of Alzheimer\u2019s disease. Front Pharmacol 10:778","journal-title":"Front Pharmacol"},{"issue":"1","key":"3556_CR79","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1006\/nbdi.1999.0271","volume":"7","author":"SH Zaman","year":"2000","unstructured":"Zaman SH et al (2000) Enhanced synaptic potentiation in transgenic mice expressing presenilin 1 familial Alzheimer\u2019s disease mutation is normalized with a benzodiazepine. Neurobiol Dis 7(1):54\u201363","journal-title":"Neurobiol Dis"},{"issue":"1","key":"3556_CR80","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1006\/nbdi.1998.0207","volume":"6","author":"A Parent","year":"1999","unstructured":"Parent A et al (1999) Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1. Neurobiol Dis 6(1):56\u201362","journal-title":"Neurobiol Dis"},{"issue":"3","key":"3556_CR81","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","volume":"39","author":"S Oddo","year":"2003","unstructured":"Oddo S et al (2003) Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39(3):409\u2013421","journal-title":"Neuron"},{"issue":"32","key":"3556_CR82","doi-asserted-by":"publisher","first-page":"10144","DOI":"10.1523\/JNEUROSCI.1856-09.2009","volume":"29","author":"A Auffret","year":"2009","unstructured":"Auffret A et al (2009) Age-dependent impairment of spine morphology and synaptic plasticity in hippocampal CA1 neurons of a presenilin 1 transgenic mouse model of Alzheimer\u2019s disease. J Neurosci 29(32):10144\u201310152","journal-title":"J Neurosci"},{"issue":"3","key":"3556_CR83","doi-asserted-by":"publisher","first-page":"e91203","DOI":"10.1371\/journal.pone.0091203","volume":"9","author":"KE Davis","year":"2014","unstructured":"Davis KE, Fox S, Gigg J (2014) Increased hippocampal excitability in the 3xTgAD mouse model for Alzheimer\u2019s disease in vivo. PLoS One 9(3):e91203","journal-title":"PLoS One"},{"key":"3556_CR84","doi-asserted-by":"crossref","first-page":"726197","DOI":"10.4061\/2011\/726197","volume":"2011","author":"ER Tuminello","year":"2011","unstructured":"Tuminello ER, Han SD (2011) The apolipoprotein e antagonistic pleiotropy hypothesis: review and recommendations. Int J Alzheimers Dis 2011:726197","journal-title":"Int J Alzheimers Dis"},{"issue":"4","key":"3556_CR85","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.jalz.2008.02.006","volume":"4","author":"SD Han","year":"2008","unstructured":"Han SD, Bondi MW (2008) Revision of the apolipoprotein E compensatory mechanism recruitment hypothesis. Alzheimers Dement 4(4):251\u2013254","journal-title":"Alzheimers Dement"},{"key":"3556_CR86","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3389\/fnagi.2017.00071","volume":"9","author":"SF Kazim","year":"2017","unstructured":"Kazim SF et al (2017) Early-onset network hyperexcitability in presymptomatic Alzheimer\u2019s disease transgenic mice is suppressed by passive immunization with anti-human APP\/Abeta antibody and by mGluR5 blockade. Front Aging Neurosci 9:71","journal-title":"Front Aging Neurosci"},{"issue":"12","key":"3556_CR87","doi-asserted-by":"publisher","first-page":"3380","DOI":"10.1038\/s41380-019-0483-4","volume":"25","author":"S Hijazi","year":"2020","unstructured":"Hijazi S et al (2020) Early restoration of parvalbumin interneuron activity prevents memory loss and network hyperexcitability in a mouse model of Alzheimer\u2019s disease. Mol Psychiatry 25(12):3380\u20133398","journal-title":"Mol Psychiatry"},{"issue":"1","key":"3556_CR88","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s13024-019-0324-6","volume":"14","author":"R Najm","year":"2019","unstructured":"Najm R, Jones EA, Huang Y (2019) Apolipoprotein E4, inhibitory network dysfunction, and Alzheimer\u2019s disease. Mol Neurodegener 14(1):24","journal-title":"Mol Neurodegener"},{"key":"3556_CR89","doi-asserted-by":"publisher","first-page":"104724","DOI":"10.1016\/j.nbd.2019.104724","volume":"136","author":"SA Flowers","year":"2020","unstructured":"Flowers SA, Rebeck GW (2020) APOE in the normal brain. Neurobiol Dis 136:104724","journal-title":"Neurobiol Dis"},{"key":"3556_CR90","doi-asserted-by":"publisher","first-page":"734001","DOI":"10.3389\/fnins.2021.734001","volume":"15","author":"SC Konings","year":"2021","unstructured":"Konings SC et al (2021) Astrocytic and neuronal apolipoprotein E isoforms differentially affect neuronal excitability. Front Neurosci 15:734001","journal-title":"Front Neurosci"},{"issue":"1","key":"3556_CR91","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/s13024-020-00382-8","volume":"15","author":"R Larramona-Arcas","year":"2020","unstructured":"Larramona-Arcas R et al (2020) Sex-dependent calcium hyperactivity due to lysosomal-related dysfunction in astrocytes from APOE4 versus APOE3 gene targeted replacement mice. Mol Neurodegener 15(1):35","journal-title":"Mol Neurodegener"},{"issue":"42","key":"3556_CR92","doi-asserted-by":"publisher","first-page":"8686","DOI":"10.1523\/JNEUROSCI.0435-21.2021","volume":"41","author":"S Ramakrishna","year":"2021","unstructured":"Ramakrishna S et al (2021) APOE4 affects basal and NMDAR-mediated protein synthesis in neurons by perturbing calcium homeostasis. J Neurosci 41(42):8686\u20138709","journal-title":"J Neurosci"},{"issue":"3","key":"3556_CR93","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/jnr.10138","volume":"67","author":"I Veinbergs","year":"2002","unstructured":"Veinbergs I et al (2002) Neurotoxic effects of apolipoprotein E4 are mediated via dysregulation of calcium homeostasis. J Neurosci Res 67(3):379\u2013387","journal-title":"J Neurosci Res"},{"issue":"7","key":"3556_CR94","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1007\/s11064-010-0371-4","volume":"36","author":"MJ Berridge","year":"2011","unstructured":"Berridge MJ (2011) Calcium signalling and Alzheimer\u2019s disease. Neurochem Res 36(7):1149\u20131156","journal-title":"Neurochem Res"},{"issue":"1","key":"3556_CR95","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1111\/j.1471-4159.2012.07908.x","volume":"124","author":"SB Dumanis","year":"2013","unstructured":"Dumanis SB et al (2013) APOE genotype affects the pre-synaptic compartment of glutamatergic nerve terminals. J Neurochem 124(1):4\u201314","journal-title":"J Neurochem"},{"issue":"42","key":"3556_CR96","doi-asserted-by":"publisher","first-page":"39944","DOI":"10.1074\/jbc.M205147200","volume":"277","author":"EJ Weeber","year":"2002","unstructured":"Weeber EJ et al (2002) Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning. J Biol Chem 277(42):39944\u201339952","journal-title":"J Biol Chem"},{"issue":"2","key":"3556_CR97","doi-asserted-by":"publisher","first-page":"469","DOI":"10.3233\/JAD-181035","volume":"67","author":"JW Wright","year":"2019","unstructured":"Wright JW, Harding JW (2019) Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer\u2019s disease. J Alzheimers Dis 67(2):469\u2013480","journal-title":"J Alzheimers Dis"},{"key":"3556_CR98","doi-asserted-by":"crossref","unstructured":"Jackson L et al (2018) Within the brain: the renin angiotensin system. Int J Mol Sci 19(3)","DOI":"10.3390\/ijms19030876"},{"issue":"5","key":"3556_CR99","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1161\/HYPERTENSIONAHA.118.11775","volume":"72","author":"LJ Trigiani","year":"2018","unstructured":"Trigiani LJ et al (2018) Pleiotropic benefits of the angiotensin receptor blocker candesartan in a mouse model of Alzheimer disease. Hypertension 72(5):1217\u20131226","journal-title":"Hypertension"},{"issue":"6","key":"3556_CR100","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1161\/HYPERTENSIONAHA.119.14431","volume":"75","author":"J Royea","year":"2020","unstructured":"Royea J et al (2020) AT2R\u2019s (angiotensin II type 2 receptor\u2019s) role in cognitive and cerebrovascular deficits in a mouse model of Alzheimer disease. Hypertension 75(6):1464\u20131474","journal-title":"Hypertension"},{"issue":"1","key":"3556_CR101","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13195-021-00778-8","volume":"13","author":"M Ouk","year":"2021","unstructured":"Ouk M et al (2021) The use of angiotensin-converting enzyme inhibitors vs. angiotensin receptor blockers and cognitive decline in Alzheimer\u2019s disease: the importance of blood-brain barrier penetration and APOE epsilon4 carrier status. Alzheimers Res Ther 13(1):43","journal-title":"Alzheimers Res Ther"},{"issue":"2","key":"3556_CR102","doi-asserted-by":"publisher","first-page":"421","DOI":"10.3233\/JAD-130716","volume":"37","author":"WQ Qiu","year":"2013","unstructured":"Qiu WQ et al (2013) Angiotensin converting enzyme inhibitors and the reduced risk of Alzheimer\u2019s disease in the absence of apolipoprotein E4 allele. J Alzheimers Dis 37(2):421\u2013428","journal-title":"J Alzheimers Dis"},{"issue":"5","key":"3556_CR103","doi-asserted-by":"publisher","first-page":"R1340","DOI":"10.1152\/ajpregu.00505.2002","volume":"284","author":"KL Barnes","year":"2003","unstructured":"Barnes KL, DeWeese DM, Andresen MC (2003) Angiotensin potentiates excitatory sensory synaptic transmission to medial solitary tract nucleus neurons. Am J Physiol Regul Integr Comp Physiol 284(5):R1340\u2013R1353","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1","key":"3556_CR104","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1016\/0306-4522(94)90322-0","volume":"62","author":"H Xiong","year":"1994","unstructured":"Xiong H, Marshall KC (1994) Angiotensin II depresses glutamate depolarizations and excitatory postsynaptic potentials in locus coeruleus through angiotensin II subtype 2 receptors. Neuroscience 62(1):163\u2013175","journal-title":"Neuroscience"},{"issue":"2","key":"3556_CR105","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/0006-8993(91)90812-A","volume":"567","author":"JB Denny","year":"1991","unstructured":"Denny JB et al (1991) Angiotensin II blocks hippocampal long-term potentiation. Brain Res 567(2):321\u2013324","journal-title":"Brain Res"},{"issue":"6","key":"3556_CR106","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/S0196-9781(98)00044-8","volume":"19","author":"O von Bohlenund Halbach","year":"1998","unstructured":"von Bohlenund Halbach O, Albrecht D (1998) Angiotensin II inhibits long-term potentiation within the lateral nucleus of the amygdala through AT1 receptors. Peptides 19(6):1031\u20131036","journal-title":"Peptides"},{"issue":"12","key":"3556_CR107","doi-asserted-by":"publisher","first-page":"4452","DOI":"10.1523\/JNEUROSCI.20-12-04452.2000","volume":"20","author":"WY Lu","year":"2000","unstructured":"Lu WY et al (2000) In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors. J Neurosci 20(12):4452\u20134461","journal-title":"J Neurosci"},{"issue":"6","key":"3556_CR108","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1124\/mol.54.6.1055","volume":"54","author":"ZG Xiong","year":"1998","unstructured":"Xiong ZG et al (1998) Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Mol Pharmacol 54(6):1055\u20131063","journal-title":"Mol Pharmacol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03556-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03556-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03556-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,26]],"date-time":"2024-10-26T04:40:31Z","timestamp":1729917631000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03556-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":108,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["3556"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03556-9","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-2960437\/v1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"22 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Research Involving Human Participants and\/or Animals"}},{"value":"All protocols follow the UIC Institutional Animal Care and Use Committee protocols.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}