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The study aimed to determine whether 2-ME2 is a potentially cancer-protective or rather neurodegenerative agent in a specific tissue culture model as well as a clinical setup. In this study, 2-ME2 activity was determined in a Parkinson\u2019s disease (PD) in vitro model based on the neuroblastoma SH-SY5Y cell line. The obtained results suggest that 2-ME2 generates nitro-oxidative stress and controls heat shock proteins (HSP), resulting in DNA strand breakage and apoptosis. On the one hand, it may affect intensely dividing cells preventing cancer development; however, on the other hand, this kind of activity within the central nervous system may promote neurodegenerative diseases like PD. Thus, the translational value of 2-ME2\u2019s neurotoxic activity in a PD in vitro model was also investigated. LC\u2013MS\/MS technique was used to evaluate estrogens and their derivatives, namely, hydroxy and methoxyestrogens, in PD patients\u2019 blood, whereas the stopped-flow method was used to assess hydrogen peroxide (H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>) levels. Methoxyestrogens and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels were increased in patients\u2019 blood as compared to control subjects, but hydoxyestrogens were simultaneously decreased. From the above, we suggest that the determination of plasma levels of methoxyestrogens and H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> may be a novel PD biomarker. The presented research is the subject of the pending patent application \u201cThe use of hydrogen peroxide and 17\u03b2-estradiol and its metabolites as biomarkers in the diagnosis of neurodegenerative diseases,\u201d no. 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