{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T03:15:25Z","timestamp":1784171725561,"version":"3.55.0"},"reference-count":75,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T00:00:00Z","timestamp":1693353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304450\/2019-7"],"award-info":[{"award-number":["304450\/2019-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["420695\/2018-4"],"award-info":[{"award-number":["420695\/2018-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["140290\/2019-2"],"award-info":[{"award-number":["140290\/2019-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004263","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul","doi-asserted-by":"publisher","award":["17\/2551-0000977-0"],"award-info":[{"award-number":["17\/2551-0000977-0"]}],"id":[{"id":"10.13039\/501100004263","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s12035-023-03584-5","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T17:02:06Z","timestamp":1693414926000},"page":"609-621","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Locomotor Behavior and Memory Dysfunction Induced by 3-Nitropropionic Acid in Adult Zebrafish: Modulation of Dopaminergic Signaling"],"prefix":"10.1007","volume":"61","author":[{"given":"Melissa Talita","family":"Wiprich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaela","family":"da Rosa Vasques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darlan","family":"Gusso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"R\u00fcbensam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza Wilges","family":"Kist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio Reis","family":"Bogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-6244","authenticated-orcid":false,"given":"Carla Denise","family":"Bonan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,8,30]]},"reference":[{"key":"3584_CR1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"The Huntington\u2019s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes","year":"1993","unstructured":"The Huntington\u2019s Disease Collaborative Research Group. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes (1993) The huntington\u2019s disease collaborative research group. Cell 72:971\u2013983","journal-title":"Cell"},{"key":"3584_CR2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s10072-019-04177-8","volume":"41","author":"E Capiluppi","year":"2020","unstructured":"Capiluppi E, Romano L, Rebora P, Nanetti L, Castaldo A, Gellera C, Mariotti C, Macerollo A et al (2020) Late-onset Huntington\u2019s disease with 40\u201342 CAG expansion. Neurol Sci 41:869\u2013876","journal-title":"Neurol Sci"},{"issue":"1","key":"3584_CR3","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/1073858420972662","volume":"28","author":"C Cepeda","year":"2022","unstructured":"Cepeda C, Levine MS (2022) Synaptic dysfunction in Huntington\u2019s disease: lessons from genetic animal models. Neuroscientist 28(1):20\u201340","journal-title":"Neuroscientist"},{"key":"3584_CR4","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.parkreldis.2017.11.001","volume":"46","author":"EM Coppen","year":"2018","unstructured":"Coppen EM, Jacobs M, van den Berg-Huysmans AA, van der Grond J, Roos RAC (2018) Grey matter volume loss is associated with specific clinical motor signs in Huntington\u2019s disease. Parkinsonism Relat Disord 46:56\u201361","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"3584_CR5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s40265-016-0670-4","volume":"77","author":"EM Coppen","year":"2017","unstructured":"Coppen EM, Roos RAC (2017) Current pharmacological approaches to reduce chorea in Huntington\u2019s disease. Drugs 77(1):29\u201346","journal-title":"Drugs"},{"key":"3584_CR6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ncl.2020.01.010","volume":"38","author":"CM Stahl","year":"2020","unstructured":"Stahl CM, Feigin A (2020) Medical, surgical, and genetic treatment of Huntington disease. Neurol Clin 38:367\u2013378","journal-title":"Neurol Clin"},{"key":"3584_CR7","doi-asserted-by":"crossref","first-page":"105574","DOI":"10.1016\/j.nbd.2021.105574","volume":"162","author":"J Barry","year":"2022","unstructured":"Barry J, Bui MTN, Levine MS, Cepeda C (2022) Synaptic pathology in Huntington\u2019s disease: beyond the corticostriatal pathway. Neurobiol Dis 162:105574","journal-title":"Neurobiol Dis"},{"issue":"1","key":"3584_CR8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s10571-018-0632-3","volume":"39","author":"MO Klein","year":"2019","unstructured":"Klein MO, Battagello DS, Cardoso AR, Hauser DN, Bittencourt JC, Correa RG (2019) Dopamine: functions, signaling, and association with neurological disease. Cell Mol Neurobiol 39(1):31\u201359","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"3584_CR9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/brain\/97.1.457","volume":"97","author":"ED Bird","year":"1974","unstructured":"Bird ED, Iversen LL (1974) Huntington\u2019s chorea. Post-mortem measurement of glutamic acid decarboxylase, choline acetyltransferase and dopamine in basal ganglia. Brain 97(3):457\u2013472","journal-title":"Brain"},{"issue":"1","key":"3584_CR10","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1111\/j.1471-4159.1992.tb09283.x","volume":"58","author":"MC Garret","year":"1992","unstructured":"Garret MC, Soares-da-Silva P (1992) Increased cerebrospinal fluid dopamine and 3,4-dihydroxyphenylacetic acid levels in Huntington\u2019s disease: evidence for an overactive dopaminergic brain transmission. J Neurochem 58(1):101\u2013110","journal-title":"J Neurochem"},{"issue":"2","key":"3584_CR11","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000375126","volume":"15","author":"GM Dall\u00e9rac","year":"2015","unstructured":"Dall\u00e9rac GM, Levasseur G, Vatsavayai SC, Milnerwood AJ, Cummings DM, Kraev I, Huetz C, Evans KA et al (2015) Dysfunctional dopaminergic neurons in mouse models of Huntington\u2019s disease: a role for SK3 channels. Neurodegener Dis 15(2):93\u2013108","journal-title":"Neurodegener Dis"},{"issue":"11","key":"3584_CR12","doi-asserted-by":"crossref","first-page":"6480","DOI":"10.1073\/pnas.95.11.6480","volume":"95","author":"JH Cha","year":"1998","unstructured":"Cha JH, Kosinski CM, Alsdorf SA, Mangiarini L, Davies SW, Penney JB, Bates GP, Young AB (1998) Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene. Proc Natl Acad Sci U S A 95(11):6480\u20136485","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3584_CR13","doi-asserted-by":"crossref","first-page":"R509","DOI":"10.1016\/S0960-9822(00)00593-5","volume":"l10","author":"AM Graybiel","year":"2000","unstructured":"Graybiel AM (2000) The basal ganglia. Curr Bio l10:R509\u2013R511","journal-title":"Curr Bio"},{"key":"3584_CR14","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0301-0082(99)00005-2","volume":"59","author":"E Brouillet","year":"1999","unstructured":"Brouillet E, Cond\u00e9 F, Beal MF, Hantraye P (1999) Replicating Huntington\u2019s disease phenotype in experimental animals. Prog Neurobiol 59:427\u2013468","journal-title":"Prog Neurobiol"},{"key":"3584_CR15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/ana.410310202","volume":"31","author":"MF Beal","year":"1992","unstructured":"Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann Neurol 31:119\u2013130","journal-title":"Ann Neurol"},{"key":"3584_CR16","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/ana.410390317","volume":"39","author":"M Gu","year":"1996","unstructured":"Gu M, Gash MT, Mann VM, Javoy-Agid F, Cooper JM, Schapira AHV (1996) Mitochondrial defect in Huntington\u2019s disease caudate nucleus. Ann Neurol 39:385\u2013389","journal-title":"Ann Neurol"},{"key":"3584_CR17","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1046\/j.1471-4159.1998.70020794.x","volume":"70","author":"E Brouillet","year":"1998","unstructured":"Brouillet E, Guyot MC, Mittoux V, Altairac S, Cond\u00e9 F, Palfi S, Hantraye P (1998) Partial inhibition of brain succinate dehydrogenase by 3-nitropropionic acid is sufficient to initiate striatal degeneration in rat. J Neurochem 70:794\u2013805","journal-title":"J Neurochem"},{"key":"3584_CR18","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1007\/s11011-017-0086-1","volume":"32","author":"CF Bortolatto","year":"2017","unstructured":"Bortolatto CF, Reis AS, Pinz MP, Voss GT, Oliveira RL, Vogt AG, Roman S, Jesse CR et al (2017) Selective A2A receptor antagonist SCH 58261 modulates striatal oxidative stress and alleviates toxicity induced by 3-nitropropionic acid in male Wistar rats. Metab Brain Dis 32:1919\u20131927","journal-title":"Metab Brain Dis"},{"key":"3584_CR19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S1385-299X(96)00037-2","volume":"1","author":"CV Borlongan","year":"1997","unstructured":"Borlongan CV, Koutouzis TK, Freeman TB, Hauser RA, Cahill DW, Sanberg PR (1997) Hyperactivity and hypoactivity in a rat model of Huntington\u2019s disease: the systemic 3-nitropropionic acid model. Brain Res Brain Res Protoc 1:253\u2013257","journal-title":"Brain Res Brain Res Protoc"},{"key":"3584_CR20","doi-asserted-by":"crossref","first-page":"108772","DOI":"10.1016\/j.cbpc.2020.108772","volume":"234","author":"MT Wiprich","year":"2020","unstructured":"Wiprich MT, Zanandrea R, Altenhofen S, Bonan CD (2020) Influence of 3-nitropropionic acid on physiological and behavioral responses in zebrafish larvae and adults. Comp Biochem Physiol C Toxicol Pharmacol 234:108772","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"issue":"3","key":"3584_CR21","first-page":"524","volume":"20","author":"K Kiper","year":"2021","unstructured":"Kiper K, Freeman JL (2021) Use of zebrafish genetic models to study etiology of the amyloid-beta and neurofibrillary tangle pathways in Alzheimer\u2019s disease. Curr Neuropharmacol 20(3):524\u201339","journal-title":"Curr Neuropharmacol"},{"key":"3584_CR22","doi-asserted-by":"crossref","first-page":"655550","DOI":"10.3389\/fgene.2021.655550","volume":"12","author":"K Razali","year":"2021","unstructured":"Razali K, Othman N, Mohd Nasir MH, Doolaanea AA, Kumar J, Ibrahim WN, Mohamed Ibrahim N, Mohamed W (2021) The promise of the zebrafish model for Parkinson\u2019s disease: today\u2019s science and tomorrow\u2019s treatment. Front Genet 12:655550","journal-title":"Front Genet"},{"key":"3584_CR23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.genrep.2018.03.001","volume":"11","author":"HJ Chakraborty","year":"2018","unstructured":"Chakraborty HJ, Rout AK, Behera BK, Parhi J, Parida PK, Das BK (2018) Insights into the aquaporin 4 of zebrafish (Danio rerio) through evolutionary analysis, molecular modeling and structural dynamics. Gene Rep 11:101\u2013109","journal-title":"Gene Rep"},{"issue":"1\u20132","key":"3584_CR24","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0006-8993(00)03174-7","volume":"889","author":"E Rink","year":"2001","unstructured":"Rink E, Wullimann MF (2001) The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum). Brain Res 889(1\u20132):316\u2013330","journal-title":"Brain Res"},{"key":"3584_CR25","doi-asserted-by":"crossref","first-page":"112031","DOI":"10.1016\/j.bbr.2019.112031","volume":"372","author":"DJ Lv","year":"2019","unstructured":"Lv DJ, Li LX, Chen J, Wei SZ, Wang F, Hu H, Xie AM, Liu CF (2019) Sleep deprivation caused a memory defects and emotional changes in a rotenone-based zebrafish model of Parkinson\u2019s disease. Behav Brain Res 372:112031","journal-title":"Behav Brain Res"},{"key":"3584_CR26","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.bbr.2018.06.017","volume":"359","author":"PO Th\u00f6rnqvist","year":"2019","unstructured":"Th\u00f6rnqvist PO, McCarrick S, Ericsson M, Roman E, Winberg S (2019) Bold zebrafish (Danio rerio) express higher levels of delta opioid and dopamine D2 receptors in the brain compared to shy fish. Behav Brain Res 359:927\u2013934","journal-title":"Behav Brain Res"},{"key":"3584_CR27","doi-asserted-by":"crossref","first-page":"172909","DOI":"10.1016\/j.pbb.2020.172909","volume":"192","author":"IM Paiva","year":"2020","unstructured":"Paiva IM, Sartori BM, Castro TFD, Lunkes LC, Virote BCR, Murgas LDS, de Souza RP, Brunialti-Godard AL (2020) Behavioral plasticity and gene regulation in the brain during an intermittent ethanol exposure in adult zebrafish population. Pharmacol Biochem Behav 192:172909","journal-title":"Pharmacol Biochem Behav"},{"key":"3584_CR28","volume-title":"The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio)","author":"M Westerfield","year":"2000","unstructured":"Westerfield M (2000) The zebrafish book. A guide for the laboratory use of zebrafish (Danio rerio), 4th edn. University of Oregon Press, Eugene","edition":"4"},{"key":"3584_CR29","doi-asserted-by":"crossref","first-page":"108936","DOI":"10.1016\/j.cbpc.2020.108936","volume":"242","author":"BD Petersen","year":"2021","unstructured":"Petersen BD, Pereira TCB, Altenhofen S, Nabinger DD, Ferreira PMA, Bogo MR, Bonan CD (2021) Antibiotic drugs alter zebrafish behavior. Comp Biochem Physiol C Toxicol Pharmacol 242:108936","journal-title":"Comp Biochem Physiol C Toxicol Pharmacol"},{"key":"3584_CR30","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.pnpbp.2019.03.014","volume":"93","author":"R Mocelin","year":"2019","unstructured":"Mocelin R, Marcon M, Araujo ASR, Herrmann AP, Piato A (2019) Withdrawal effects following repeated ethanol exposure are prevented by N-acetylcysteine in zebrafish. Prog Neuropsychopharmacol Biol Psychiatry 93:161\u2013170","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3584_CR31","doi-asserted-by":"crossref","first-page":"112264","DOI":"10.1016\/j.bbr.2019.112264","volume":"378","author":"ACVV Giacomini","year":"2020","unstructured":"Giacomini ACVV, Piassetta AS, Genario R, Bonan CD, Piato A, Barcellos LJG, de Abreu MS (2020) Tryptophan alleviates neuroendocrine and behavioral responses to stress in zebrafish. Behav Brain Res 378:112264","journal-title":"Behav Brain Res"},{"issue":"5","key":"3584_CR32","first-page":"3866","volume":"55","author":"S Altenhofen","year":"2018","unstructured":"Altenhofen S, Nabinger DD, Pereira TCB, Leite CE, Bogo MR, Bonan CD (2018) Manganese(II) chloride alters nucleotide and nucleoside catabolism in zebrafish (Danio rerio) adult brain. Mol Neurobiol 55(5):3866\u20133874","journal-title":"Mol Neurobiol"},{"key":"3584_CR33","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1007\/s12035-020-01970-x","volume":"57","author":"R Zanandrea","year":"2020","unstructured":"Zanandrea R, Wiprich MT, Altenhofen S, Rubensam G, Dos Santos TM, Wyse ATS, Bonan CD (2020) Withdrawal effects following methionine exposure in adult zebrafish. Mol Neurobiol 57:3485\u20133497","journal-title":"Mol Neurobiol"},{"issue":"4","key":"3584_CR34","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1556\/ABiol.60.2009.4.3","volume":"60","author":"A Luk\u00e1cs","year":"2009","unstructured":"Luk\u00e1cs A, Szab\u00f3 A, Papp A, Vez\u00e9r T (2009) Altered open field behavior in rats induced by acute administration of 3-nitropropionic acid: possible glutamatergic and dopaminergic involvement. Acta Biol Hung 60(4):359\u2013367","journal-title":"Acta Biol Hung"},{"issue":"4","key":"3584_CR35","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.pbb.2005.06.013","volume":"81","author":"JL Taylor","year":"2005","unstructured":"Taylor JL, Bishop C, Walker PD (2005) Dopamine D1 and D2 receptor contributions to L-DOPA-induced dyskinesia in the dopamine-depleted rat. Pharmacol Biochem Behav 81(4):887\u2013893","journal-title":"Pharmacol Biochem Behav"},{"key":"3584_CR36","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","volume":"72","author":"MM Bradford","year":"1976","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248\u2013254","journal-title":"Anal Biochem"},{"key":"3584_CR37","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","volume":"29","author":"MW Pfaff","year":"2001","unstructured":"Pfaff MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45","journal-title":"Nucleic Acids Res"},{"key":"3584_CR38","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1745-7270.2007.00283.x","volume":"39","author":"R Tang","year":"2007","unstructured":"Tang R, Dodd A, Lai D, McNabb WC, Love DR (2007) Validation of zebrafish (Danio rerio) reference genes for quantitative real-time RT-PCR normalization. Acta Biochim Biophys Sin (Shanghai) 39:384\u2013390","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"3584_CR39","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.nlm.2009.07.001","volume":"92","author":"M Blank","year":"2009","unstructured":"Blank M, Guerim LD, Cordeiro RF, Vianna MRM (2009) A one-trial inhibitory avoidance task to zebrafish: rapid acquisition of an NMDA-dependent long-term memory. Neurobiol Learn Mem 92:529\u2013534","journal-title":"Neurobiol Learn Mem"},{"key":"3584_CR40","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.toxrep.2015.08.004","volume":"2","author":"N Kaur","year":"2015","unstructured":"Kaur N, Jamwal S, Deshmukh R, Gauttam V, Kumar P (2015) Beneficial effect of rice bran extract against 3-nitropropionic acid induced experimental Huntington\u2019s disease in rat. Toxicol Rep 2:1222\u20131232","journal-title":"Toxicol Rep"},{"issue":"1","key":"3584_CR41","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.pnpbp.2008.10.013","volume":"33","author":"P Kumar","year":"2009","unstructured":"Kumar P, Kumar A (2009) Possible role of sertraline against 3-nitropropionic acid induced behavioral, oxidative stress and mitochondrial dysfunctions in rat brain. Prog Neuropsychopharmacol Biol Psychiatry 33(1):100\u2013108","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3584_CR42","first-page":"1","volume":"15","author":"M Salman","year":"2021","unstructured":"Salman M, Sharma P, Alam MI, Tabassum H, Parvez S (2021) Naringenin mitigates behavioral alterations and provides neuroprotection against 3-nitropropinoic acid-induced Huntington\u2019s disease like symptoms in rats. Nutr Neurosci 15:1\u201311","journal-title":"Nutr Neurosci"},{"issue":"4","key":"3584_CR43","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0022-510X(73)90175-5","volume":"20","author":"A Bernheimer","year":"1973","unstructured":"Bernheimer A, Birkmayer W, Hornykiewicz O, Jellinger K, Seitelberger F (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J Neurol Sci 20(4):415\u2013455","journal-title":"J Neurol Sci"},{"issue":"3","key":"3584_CR44","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ana.410220318","volume":"22","author":"SJ Kish","year":"1987","unstructured":"Kish SJ, Shannak K, Hornykiewicz O (1987) Elevated serotonin and reduced dopamine in subregionally divided Huntington\u2019s disease striatum. Ann Neurol 22(3):386\u2013389","journal-title":"Ann Neurol"},{"issue":"6","key":"3584_CR45","doi-asserted-by":"crossref","first-page":"2667","DOI":"10.1152\/jn.2001.86.6.2667","volume":"86","author":"GJ Klapstein","year":"2001","unstructured":"Klapstein GJ, Fisher RS, Zanjani H, Cepeda C, Jokel ES, Chesselet MF, Levine MS (2001) Electrophysiological and morphological changes in striatal spiny neurons in R6\/2 Huntington\u2019s disease transgenic mice. J Neurophysiol 86(6):2667\u20132677","journal-title":"J Neurophysiol"},{"issue":"4","key":"3584_CR46","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1523\/JNEUROSCI.3539-10.2011","volume":"31","author":"VM Andre","year":"2011","unstructured":"Andre VM, Cepeda C, Fisher YE, Huynh M, Bardakjian N, Singh S, Yang XW, Levine MS (2011) Differential electrophysiological changes in striatal output neurons in Huntington\u2019s disease. J Neurosci 31(4):1170\u20131182","journal-title":"J Neurosci"},{"issue":"4","key":"3584_CR47","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1139\/apnm-2013-0262","volume":"39","author":"KM Denny Joseph","year":"2014","unstructured":"Denny Joseph KM, Muralidhara, (2014) Neuroprotective efficacy of a combination of fish oil and ferulic acid against 3-nitropropionic acid-induced oxidative stress and neurotoxicity in rats: behavioral and biochemical evidence. Appl Physiol Nutr Metab 39(4):487\u2013496","journal-title":"Appl Physiol Nutr Metab"},{"key":"3584_CR48","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.physbeh.2015.12.015","volume":"155","author":"S Jamwal","year":"2016","unstructured":"Jamwal S, Kumar P (2016) Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: possible role of oxidative stress, neuroinflammation, and neurotransmitters. Physiol Behav 155:180\u2013187","journal-title":"Physiol Behav"},{"issue":"1","key":"3584_CR49","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.neulet.2006.09.070","volume":"410","author":"ZK Binienda","year":"2006","unstructured":"Binienda ZK, Ali SF, Virmani A, Amato A, Salem N, Przybyla BD (2006) Co-regulation of dopamine D1 receptor and uncoupling protein-2 expression in 3-nitroproionic acid-induced neurotoxicity: neuroprotective role of L-carnitine. Neurosci Lett 410(1):62\u201365","journal-title":"Neurosci Lett"},{"issue":"2","key":"3584_CR50","doi-asserted-by":"crossref","first-page":"e0192289","DOI":"10.1371\/journal.pone.0192289","volume":"13","author":"G Manfr\u00e9","year":"2018","unstructured":"Manfr\u00e9 G, Novati A, Faccini I, Rossetti AC, Bosch K, Molteni R, Riva MA, Van der Harst JE et al (2018) BACHD rats expressing full-length mutant huntingtin exhibit differences in social behavior compared to wild-type littermates. PLoS One 13(2):e0192289","journal-title":"PLoS One"},{"issue":"1","key":"3584_CR51","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.neuroscience.2009.06.014","volume":"163","author":"MJ Dowie","year":"2009","unstructured":"Dowie MJ, Bradshaw HB, Nicholson LFB, Faull RLM, Hannan AJ, Glass M (2009) Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic model of Huntington\u2019s disease. Neuroscience 163(1):456\u2013465","journal-title":"Neuroscience"},{"key":"3584_CR52","doi-asserted-by":"crossref","first-page":"136289","DOI":"10.1016\/j.neulet.2021.136289","volume":"767","author":"KL Harris","year":"2022","unstructured":"Harris KL, Mason SL, Vallin B, Barker RA (2022) Reduced expression of dopamine D2 receptors on astrocytes in R6\/1 mice and HD post-mortem tissue. Neurosci Lett 767:136289","journal-title":"Neurosci Lett"},{"issue":"17","key":"3584_CR53","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1093\/hmg\/11.17.1939","volume":"11","author":"EYW Chan","year":"2002","unstructured":"Chan EYW, Luthi-Carter R, Strand A, Solano MS, Hanson SA, DeJohn MM, Kooperberg C, Chase KO et al (2002) Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington\u2019s disease. Hum Mol Genet 11(17):1939\u20131951","journal-title":"Hum Mol Genet"},{"issue":"1","key":"3584_CR54","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3390\/brainsci10010043","volume":"10","author":"A Kumar","year":"2020","unstructured":"Kumar A, Kumar V, Singh K, Kumar S, Kim YS, Lee YN, Kim JJ (2020) Therapeutic advances for Huntington\u2019s disease. Brain Sci 10(1):43","journal-title":"Brain Sci"},{"issue":"4","key":"3584_CR55","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1515\/revneuro-2019-0085","volume":"31","author":"M Jablonska","year":"2020","unstructured":"Jablonska M, Grzelakowska K, Wisniewski B, Mazur E, Leis K, Galazka P (2020) Pridopidine in the treatment of Huntington\u2019s disease. Rev Neurosci 31(4):441\u2013451","journal-title":"Rev Neurosci"},{"issue":"16","key":"3584_CR56","doi-asserted-by":"crossref","first-page":"8363","DOI":"10.3390\/ijms22168363","volume":"22","author":"A Kim","year":"2021","unstructured":"Kim A, Lalonde K, Truesdell A, Welter PG, Brocardo PS, Rosenstock TR, Gil-Mohapel J (2021) New avenues for the treatment of Huntington\u2019s disease. Int J Mol Sci 22(16):8363","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3584_CR57","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/mds.23953","volume":"27","author":"CS Venuto","year":"2012","unstructured":"Venuto CS, McGarry A, Ma Q, Kieburtz K (2012) Pharmacological approaches to the treatment of Huntington\u2019s disease. Mov Disord 27(1):31\u201341","journal-title":"Mov Disord"},{"key":"3584_CR58","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000128941","volume":"146","author":"F Gerstenbrand","year":"1963","unstructured":"Gerstenbrand F, Pateisky K, Prosenz P (1963) Experiences with L-dopa in the therapy of parkinsonism. Psychiatr Neurol (Basel) 146:246\u2013261","journal-title":"Psychiatr Neurol (Basel)"},{"issue":"3","key":"3584_CR59","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1159\/000114017","volume":"4","author":"HL Klawans Jr","year":"1970","unstructured":"Klawans HL Jr (1970) A pharmacologic analysis of Huntington\u2019s chorea. Eur Neurol 4(3):148\u2013163","journal-title":"Eur Neurol"},{"issue":"4","key":"3584_CR60","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1136\/jnnp.65.4.577","volume":"65","author":"BA Racette","year":"1998","unstructured":"Racette BA, Perlmutter JS (1998) Levodopa responsive parkinsonism in an adult with Huntington\u2019s disease. J Neurol Neurosurg Psychiatry 65(4):577\u2013579","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"21","key":"3584_CR61","doi-asserted-by":"crossref","first-page":"2701","DOI":"10.2174\/138161206777698693","volume":"12","author":"RM Bonelli","year":"2006","unstructured":"Bonelli RM, Wenning GK (2006) Pharmacological management of Huntington\u2019s disease: an evidence-based review. Curr Pharm Des 12(21):2701\u20132720","journal-title":"Curr Pharm Des"},{"issue":"2","key":"3584_CR62","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1006\/exnr.2002.8033","volume":"178","author":"MT Armentero","year":"2002","unstructured":"Armentero MT, Fancellu R, Nappi G, Blandini F (2002) Dopamine receptor agonists mediate neuroprotection in malonate-induced striatal lesion in the rat. Exp Neurol 178(2):301\u2013305","journal-title":"Exp Neurol"},{"key":"3584_CR63","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1046\/j.1471-4159.2002.00804.x","volume":"81","author":"MA Hickey","year":"2002","unstructured":"Hickey MA, Reynolds GP, Morton AJ (2002) The role of dopamine in motor symptoms in the R6\/2 transgenic mice model of Huntington\u2019s disease. J Neurochem 81:46\u201359","journal-title":"J Neurochem"},{"issue":"19","key":"3584_CR64","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1093\/hmg\/ddl224","volume":"15","author":"DM Cummings","year":"2006","unstructured":"Cummings DM, Milnerwood AJ, Dall\u00e9rac GM, Waights V, Brown JY, Vatsavayai SC, Hirst MC, Murphy KPSJ (2006) Aberrant cortical synaptic plasticity and dopaminergic dysfunction in a mouse model of Huntington\u2019s disease. Hum Mol Genet 15(19):2856\u20132868","journal-title":"Hum Mol Genet"},{"key":"3584_CR65","doi-asserted-by":"crossref","first-page":"110602","DOI":"10.1016\/j.pnpbp.2022.110602","volume":"119","author":"MT Wiprich","year":"2022","unstructured":"Wiprich MT, Altenhofen S, Gusso D, Vasques RR, Zanandrea R, Kist LW, Bogo MR, Bonan CD (2022) Modulation of adenosine signaling reverses 3-nitropropionic acid-induced bradykinesia and memory impairment in adult zebrafish. Prog Neuropsychopharmacol Biol Psychiatry 119:110602","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3584_CR66","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.bbr.2011.11.006","volume":"227","author":"L Stiles","year":"2012","unstructured":"Stiles L, Zheng Y, Darlington CL, Smith PF (2012) The D2 dopamine receptor and locomotor hyperactivity following bilateral vestibular deafferentation in the rat. Behav Brain Res 227:150\u2013158","journal-title":"Behav Brain Res"},{"key":"3584_CR67","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1159\/000365008","volume":"93","author":"YK Wong","year":"2014","unstructured":"Wong YK, Chou MK, Shen YC, Wang YH, Yen JC, Chen CF, Lin SK, Liao JF (2014) Preventive effect of baicalein on methamphetamine-induced amnesia in the passive avoidance test in mice. Pharmacology 93:278\u2013285","journal-title":"Pharmacology"},{"key":"3584_CR68","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/s10519-017-9865-z","volume":"47","author":"RAN P\u00e9rtile","year":"2017","unstructured":"P\u00e9rtile RAN, Corvino ME, Marchette RCN, Pavesi E, Cavalli J, Ramos A, Iz\u00eddio GS (2017) The quinpirole hypolocomotive effects are strain and route administration dependent in SHR and SLA16 isogenic rats. Behav Genet 47:552\u2013563","journal-title":"Behav Genet"},{"key":"3584_CR69","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0091-3057(02)00770-0","volume":"72","author":"CW Schindler","year":"2002","unstructured":"Schindler CW, Carmona GN (2002) Effects of dopamine agonists and antagonists on locomotor activity in male and female rats. Pharmacol Biochem Behav 72:857\u2013863","journal-title":"Pharmacol Biochem Behav"},{"key":"3584_CR70","doi-asserted-by":"crossref","first-page":"2980","DOI":"10.1093\/cercor\/bhu096","volume":"25","author":"MC Puig","year":"2015","unstructured":"Puig MC, Miller EK (2015) Neural substrates of dopamine D2 receptor modulated executive functions in the monkey prefrontal cortex. Cereb Cortex 25:2980\u20132987","journal-title":"Cereb Cortex"},{"key":"3584_CR71","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbr.2016.01.034","volume":"303","author":"M Naderi","year":"2016","unstructured":"Naderi M, Jamwal A, Chivers DP, Niyogi S (2016) Modulatory effects of dopamine receptors on associative learning performance in zebrafish (Danio rerio). Behav Brain Res 303:109\u2013119","journal-title":"Behav Brain Res"},{"key":"3584_CR72","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.pbb.2006.04.012","volume":"84","author":"AR de Oliveira","year":"2006","unstructured":"de Oliveira AR, Reimer AE, Brand\u00e3o ML (2006) Dopamine D2 receptor mechanisms in the expression of conditioned fear. Pharmacol Biochem Behav 84:102\u2013111","journal-title":"Pharmacol Biochem Behav"},{"key":"3584_CR73","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2017.01.005","volume":"321","author":"L L\u00e9n\u00e1rd","year":"2017","unstructured":"L\u00e9n\u00e1rd L, Ollmann T, L\u00e1szl\u00f3 K, Kov\u00e1cs A, G\u00e1losi R, K\u00e1llai V, Attila T, Kertes E et al (2017) Role of D2 dopamine receptors of the ventral pallidum in inhibitory avoidance learning. Behav Brain Res 321:99\u2013105","journal-title":"Behav Brain Res"},{"key":"3584_CR74","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/FBP.0b013e32833a5c68","volume":"21","author":"SM Li","year":"2010","unstructured":"Li SM, Collins GT, Paul NM, Grundt P, Newman AH, Xu M, Grandy DK, Woods JH et al (2010) Yawning and locomotor behavior induced by dopamine receptor agonists in mice and rats. Behav Pharmacol 21:171\u2013181","journal-title":"Behav Pharmacol"},{"key":"3584_CR75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.14802\/jmd.21035","volume":"14","author":"P Shang","year":"2021","unstructured":"Shang P, Baker M, Banks S, Hong SI, Choi DS (2021) Emerging nondopaminergic medications for Parkinson\u2019s disease: focusing on A2A receptor antagonists and GLP1 receptor agonists. J Mov Disord 14:193\u2013203","journal-title":"J Mov Disord"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03584-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03584-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03584-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:16:48Z","timestamp":1707740208000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03584-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,30]]},"references-count":75,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["3584"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03584-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,30]]},"assertion":[{"value":"23 December 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All protocols were approved by the Institutional Animal Care Committee from Pontif\u00edcia Universidade Cat\u00f3lica do Rio Grande do Sul (CEUA-PUCRS, permit number 9406\/2019) and comply with the guideline of the National Council for the Control of Animal Experimentation (CONCEA). This study was registered in the Sistema Nacional de Gest\u00e3o do Patrim\u00f4nio Gen\u00e9tico e Conhecimento Tradicional Associado\u2013SISGEN (Protocol No A3B073D).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}