{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:36:16Z","timestamp":1791941776880,"version":"4.3.4"},"reference-count":73,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:00:00Z","timestamp":1694044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Science and Engineering Research Board (SERB), Government of India, New Delhi, India","award":["EEQ\/2019\/000213"],"award-info":[{"award-number":["EEQ\/2019\/000213"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1007\/s12035-023-03599-y","type":"journal-article","created":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T03:15:13Z","timestamp":1694056513000},"page":"982-1001","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Reinstated Activity of Human Tau-induced Enhanced Insulin Signaling Restricts Disease Pathogenesis by Regulating the Functioning of Kinases\/Phosphatases and Tau Hyperphosphorylation in Drosophila"],"prefix":"10.1007","volume":"61","author":[{"family":"Pragati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,7]]},"reference":[{"key":"3599_CR1","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1146\/annurev.neuro.24.1.1121","volume":"24","author":"VM Lee","year":"2001","unstructured":"Lee VM, Goedert M, Trojanowski JQ (2001) Neurodegenerative tauopathies. Annu Rev Neurosci 24:1121\u20131159. https:\/\/doi.org\/10.1146\/annurev.neuro.24.1.1121","journal-title":"Annu Rev Neurosci"},{"key":"3599_CR2","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1750-1326-4-13","volume":"4","author":"TF Gendron","year":"2009","unstructured":"Gendron TF, Petrucelli L (2009) The role of tau in neurodegeneration. Mol Neurodegener 4:13. https:\/\/doi.org\/10.1186\/1750-1326-4-13","journal-title":"Mol Neurodegener"},{"key":"3599_CR3","doi-asserted-by":"publisher","first-page":"42","DOI":"10.3389\/fnmol.2014.00042","volume":"7","author":"S Tenreiro","year":"2014","unstructured":"Tenreiro S, Eckermann K, Outeiro TF (2014) Protein phosphorylation in neurodegeneration: friend or foe. Front Mol Neurosci 7:42. https:\/\/doi.org\/10.3389\/fnmol.2014.00042","journal-title":"Front Mol Neurosci"},{"key":"3599_CR4","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.pneurobio.2018.12.005","volume":"175","author":"C Tapia-Rojas","year":"2019","unstructured":"Tapia-Rojas C, Cabezas-Opazo F, Deaton CA, Vergara EH, Johnson GVW, Quintanilla RA (2019) It\u2019s all about tau. Prog Neurobiol 175:54\u201376. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.12.005","journal-title":"Prog Neurobiol"},{"key":"3599_CR5","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fncel.2020.00019","volume":"14","author":"D Toral-Rios","year":"2020","unstructured":"Toral-Rios D, Pichardo-Rojas PS, Alonso-Vanegas M, Campos-Pe\u00f1a V (2020) GSK3\u03b2 and tau protein in Alzheimer\u2019s Disease and Epilepsy. Front Cell Neurosci 14:19. https:\/\/doi.org\/10.3389\/fncel.2020.00019","journal-title":"Front Cell Neurosci"},{"key":"3599_CR6","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/acel.12381","volume":"14","author":"E Lauretti","year":"2015","unstructured":"Lauretti E, Pratic\u00f2 D (2015) Glucose deprivation increases tau phosphorylation via P38 mitogen-activated protein kinase. Aging Cell 14:1067\u20131074. https:\/\/doi.org\/10.1111\/acel.12381","journal-title":"Aging Cell"},{"key":"3599_CR7","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1001\/archneur.63.11.1551","volume":"63","author":"A Akomolafe","year":"2006","unstructured":"Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S (2006) Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol 63:1551\u20131555. https:\/\/doi.org\/10.1001\/archneur.63.11.1551","journal-title":"Arch Neurol"},{"key":"3599_CR8","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.2147\/cia.s48926","volume":"9","author":"H Umegaki","year":"2014","unstructured":"Umegaki H (2014) Type 2 diabetes as a risk factor for cognitive impairment: current insights. Clin Interv Aging 9:1011\u20131019. https:\/\/doi.org\/10.2147\/cia.s48926","journal-title":"Clin Interv Aging"},{"key":"3599_CR9","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1084\/jem.20160493","volume":"213","author":"M Stanley","year":"2016","unstructured":"Stanley M, Macauley SL, Holtzman DM (2016) Changes in insulin and insulin signaling in Alzheimer\u2019s disease: cause or consequence? J Exp Med 213:1375\u20131385. https:\/\/doi.org\/10.1084\/jem.20160493","journal-title":"J Exp Med"},{"key":"3599_CR10","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3389\/fnins.2015.00204","volume":"9","author":"G Bedse","year":"2015","unstructured":"Bedse G, Di Domenico F, Serviddio G, Cassano T (2015) Aberrant insulin signaling in Alzheimer\u2019s disease: current knowledge. Front Neurosci 9:204. https:\/\/doi.org\/10.3389\/fnins.2015.00204","journal-title":"Front Neurosci"},{"key":"3599_CR11","doi-asserted-by":"publisher","first-page":"e30722","DOI":"10.1371\/journal.pone.0030722","volume":"7","author":"B Dimitroff","year":"2012","unstructured":"Dimitroff B, Howe K, Watson A, Campion B, Lee H-G, Zhao N, O\u2019Connor MB, Neufeld TP et al (2012) Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS ONE 7:e30722. https:\/\/doi.org\/10.1371\/journal.pone.0030722","journal-title":"PLoS ONE"},{"key":"3599_CR12","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1007\/s12035-018-1160-3","volume":"56","author":"K Raj","year":"2019","unstructured":"Raj K, Sarkar S (2019) Tissue-specific upregulation of Drosophila insulin receptor (InR) mitigates poly(Q)-Mediated neurotoxicity by Restoration of Cellular transcription Machinery. Mol Neurobiol 56:1310\u20131329. https:\/\/doi.org\/10.1007\/s12035-018-1160-3","journal-title":"Mol Neurobiol"},{"key":"3599_CR13","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1016\/j.cub.2018.01.060","volume":"28","author":"Y Umezaki","year":"2018","unstructured":"Umezaki Y, Hayley SE, Chu ML, Seo HW, Shah P, Hamada FN (2018) Feeding-state-dependent modulation of temperature preference requires insulin signaling in Drosophila warm-sensing neurons. Curr Biol 28:779\u2013787. https:\/\/doi.org\/10.1016\/j.cub.2018.01.060","journal-title":"Curr Biol"},{"key":"3599_CR14","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.1016\/j.celrep.2016.07.022","volume":"16","author":"DT Musashe","year":"2016","unstructured":"Musashe DT, Purice MD, Speese SD, Doherty J, Logan MA (2016) Insulin-like signaling promotes glial phagocytic clearance of degenerating axons through regulation of draper. Cell Rep 16:1838\u20131850. https:\/\/doi.org\/10.1016\/j.celrep.2016.07.022","journal-title":"Cell Rep"},{"key":"3599_CR15","doi-asserted-by":"publisher","first-page":"dev178202","DOI":"10.1242\/dev.178202","volume":"146","author":"H Kaur","year":"2019","unstructured":"Kaur H, Sharma SK, Mandal S, Mandal L (2019) Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche. Development 146:dev178202. https:\/\/doi.org\/10.1242\/dev.178202","journal-title":"Development"},{"key":"3599_CR16","doi-asserted-by":"publisher","first-page":"6341","DOI":"10.1128\/mcb.00675-09","volume":"29","author":"JR DiAngelo","year":"2009","unstructured":"DiAngelo JR, Birnbaum MJ (2009) Regulation of fat cell mass by insulin in Drosophila melanogaster. Mol Cell Biol 29:6341\u20136352. https:\/\/doi.org\/10.1128\/mcb.00675-09","journal-title":"Mol Cell Biol"},{"key":"3599_CR17","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/s0092-8674(00)81385-9","volume":"87","author":"M Freeman","year":"1996","unstructured":"Freeman M (1996) Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87:651\u2013660. https:\/\/doi.org\/10.1016\/s0092-8674(00)81385-9","journal-title":"Cell"},{"key":"3599_CR18","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1126\/science.1062382","volume":"293","author":"CW Wittmann","year":"2001","unstructured":"Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB (2001) Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293:711\u2013714. https:\/\/doi.org\/10.1126\/science.1062382","journal-title":"Science"},{"key":"3599_CR19","doi-asserted-by":"publisher","unstructured":"Iyer J, Wang Q, Le T, Pizzo L, Gr\u00f6nke S, Ambegaokar SS, Imai Y, Srivastava A et al (2016) Quantitative Assessment of Eye Phenotypes for Functional Genetic Studies using Drosophila melanogaster. G3. 6(Bethesda):1427\u20131437. https:\/\/doi.org\/10.1534\/g3.116.027060","DOI":"10.1534\/g3.116.027060"},{"key":"3599_CR20","doi-asserted-by":"publisher","first-page":"105040","DOI":"10.1016\/j.neuint.2021.105040","volume":"146","author":"SS Nisha","year":"2021","unstructured":"Nisha SS (2021) Downregulation of glob1 suppresses pathogenesis of human neuronal tauopathies in Drosophila by regulating tau phosphorylation and ROS generation. Neurochem Int 146:105040. https:\/\/doi.org\/10.1016\/j.neuint.2021.105040","journal-title":"Neurochem Int"},{"key":"3599_CR21","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/bf02215177","volume":"9","author":"N Franceschini","year":"1971","unstructured":"Franceschini N, Kirschfeld K (1971) Pseudopupil phenomena in the compound eye of Drosophila. Kybernetik 9:159\u2013182. https:\/\/doi.org\/10.1007\/bf02215177","journal-title":"Kybernetik"},{"key":"3599_CR22","doi-asserted-by":"publisher","first-page":"e19809","DOI":"10.7554\/elife.19809","volume":"5","author":"MW Rousseaux","year":"2016","unstructured":"Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A et al (2016) TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau. Elife 5:e19809. https:\/\/doi.org\/10.7554\/elife.19809","journal-title":"Elife"},{"key":"3599_CR23","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ygcen.2014.11.021","volume":"221","author":"DR N\u00e4ssel","year":"2015","unstructured":"N\u00e4ssel DR, Liu Y, Luo J (2015) Insulin\/IGF signaling and its regulation in Drosophila. Gen Comp Endocrinol 221:255\u2013266. https:\/\/doi.org\/10.1016\/j.ygcen.2014.11.021","journal-title":"Gen Comp Endocrinol"},{"key":"3599_CR24","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0960-9822(01)00068-9","volume":"11","author":"W Brogiolo","year":"2001","unstructured":"Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11:213\u2013221. https:\/\/doi.org\/10.1016\/s0960-9822(01)00068-9","journal-title":"Curr Biol"},{"key":"3599_CR25","unstructured":"De Meyts P (2016) The Insulin Receptor and Its Signal Transduction Network. K. R. Feingold, B. Anawalt, A. Boyce, G. Chrousos, W. W. de Herder, K. Dhatariya, Dungan K, Hershman JM, South Dartmouth (MA)"},{"key":"3599_CR26","doi-asserted-by":"publisher","first-page":"119358","DOI":"10.1016\/j.lfs.2021.119358","volume":"275","author":"S Tandon","year":"2021","unstructured":"Tandon S, Sarkar S (2021) The S6k\/4E-BP mediated growth promoting sub-pathway of insulin signalling cascade is essential to restrict pathogenesis of poly(Q) disorders in Drosophila. Life Sci 275:119358. https:\/\/doi.org\/10.1016\/j.lfs.2021.119358","journal-title":"Life Sci"},{"key":"3599_CR27","unstructured":"Longo N, Langley SD, Griffin LD, Elsas LJ 2nd (1992) Reduced mRNA and a nonsense mutation in the insulin-receptor gene produce heritable severe insulin resistance. Am J Hum Genet 50:998\u20131007"},{"key":"3599_CR28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1073\/pnas.90.1.60","volume":"90","author":"N Longo","year":"1993","unstructured":"Longo N, Langley SD, Griffin LD, Elsas LJ (1993) Activation of glucose transport by a natural mutation in the human insulin receptor. Proc Natl Acad Sci U S A 90:60\u201364. https:\/\/doi.org\/10.1073\/pnas.90.1.60","journal-title":"Proc Natl Acad Sci U S A"},{"key":"3599_CR29","doi-asserted-by":"publisher","first-page":"100689","DOI":"10.1016\/j.xpro.2021.100689","volume":"2","author":"JA Behnke","year":"2021","unstructured":"Behnke JA, Ye C, Moberg KH, Zheng JQ (2021) A protocol to detect neurodegeneration in Drosophila melanogaster whole-brain mounts using advanced microscopy. STAR Protoc 2:100689. https:\/\/doi.org\/10.1016\/j.xpro.2021.100689","journal-title":"STAR Protoc"},{"key":"3599_CR30","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/j.tips.2017.03.011","volume":"38","author":"ME Orr","year":"2017","unstructured":"Orr ME, Sullivan AC, Frost B (2017) A brief overview of Tauopathy: causes, Consequences, and therapeutic strategies. Trends Pharmacol Sci 38:637\u2013648. https:\/\/doi.org\/10.1016\/j.tips.2017.03.011","journal-title":"Trends Pharmacol Sci"},{"key":"3599_CR31","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1101\/lm.221206","volume":"13","author":"D-BG Akalal","year":"2006","unstructured":"Akalal D-BG, Wilson CF, Zong L, Tanaka NK, Ito K, Davis RL (2006) Roles for Drosophila mushroom body neurons in olfactory learning and memory. Learn Mem 13:659\u2013668. https:\/\/doi.org\/10.1101\/lm.221206","journal-title":"Learn Mem"},{"key":"3599_CR32","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/j.1440-169x.2007.00922.x","volume":"49","author":"K Fushima","year":"2007","unstructured":"Fushima K, Tsujimura H (2007) Precise control of fasciclin II expression is required for adult mushroom body development in Drosophila. Dev Growth Differ 49:215\u2013227. https:\/\/doi.org\/10.1111\/j.1440-169x.2007.00922.x","journal-title":"Dev Growth Differ"},{"key":"3599_CR33","doi-asserted-by":"publisher","first-page":"970980","DOI":"10.1155\/2012\/970980","volume":"2012","author":"M Gistelinck","year":"2012","unstructured":"Gistelinck M, Lambert JC, Callaerts P, Dermaut B, Dourlen P (2012) Drosophila models of tauopathies: what have we learned? Int J Alzheimers Dis 2012:970980. https:\/\/doi.org\/10.1155\/2012\/970980","journal-title":"Int J Alzheimers Dis"},{"key":"3599_CR34","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jneumeth.2019.01.001","volume":"319","author":"L Sivanantharajah","year":"2019","unstructured":"Sivanantharajah L, Mudher A, Shepherd D (2019) An evaluation of Drosophila as a model system for studying tauopathies such as Alzheimer\u2019s disease. J Neurosci Methods 319:77\u201388. https:\/\/doi.org\/10.1016\/j.jneumeth.2019.01.001","journal-title":"J Neurosci Methods"},{"key":"3599_CR35","doi-asserted-by":"publisher","first-page":"8948","DOI":"10.3390\/ijms21238948","volume":"21","author":"MC Silva","year":"2020","unstructured":"Silva MC, Haggarty SJ (2020) Tauopathies: deciphering Disease Mechanisms to develop effective therapies. Int J Mol Sci 21:8948. https:\/\/doi.org\/10.3390\/ijms21238948","journal-title":"Int J Mol Sci"},{"key":"3599_CR36","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","volume":"75","author":"F Chiti","year":"2006","unstructured":"Chiti F, Dobson CM (2006) Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem 75:333\u2013366. https:\/\/doi.org\/10.1146\/annurev.biochem.75.101304.123901","journal-title":"Annu Rev Biochem"},{"key":"3599_CR37","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1002\/eji.201040616","volume":"40","author":"T Chen","year":"2010","unstructured":"Chen T, Cao X (2010) Stress for maintaining memory: HSP70 as a mobile messenger for innate and adaptive immunity. Eur J Immunol 40:1541\u20131544. https:\/\/doi.org\/10.1002\/eji.201040616","journal-title":"Eur J Immunol"},{"key":"3599_CR38","doi-asserted-by":"publisher","first-page":"412","DOI":"10.3390\/ijms22010412","volume":"22","author":"CL Moore","year":"2021","unstructured":"Moore CL, Savenka AV, Basnakian AG (2021) TUNEL assay: a powerful Tool for kidney Injury evaluation. Int J Mol Sci 22:412. https:\/\/doi.org\/10.3390\/ijms22010412","journal-title":"Int J Mol Sci"},{"key":"3599_CR39","doi-asserted-by":"publisher","first-page":"5263","DOI":"10.1021\/acsnano.0c10690","volume":"15","author":"H Sun","year":"2021","unstructured":"Sun H, Zhong Y, Zhu X, Liao H, Lee J, Chen Y, Ma L, Ren J et al (2021) A tauopathy-homing and autophagy-activating nanoassembly for specific clearance of pathogenic tau in Alzheimer\u2019s Disease. ACS Nano 15:5263\u20135275. https:\/\/doi.org\/10.1021\/acsnano.0c10690","journal-title":"ACS Nano"},{"key":"3599_CR40","doi-asserted-by":"publisher","first-page":"2596","DOI":"10.1111\/jcmm.16274","volume":"25","author":"Y Jiang","year":"2021","unstructured":"Jiang Y, Liang J, Li R, Peng Y, Huang J, Huang L (2021) Basic fibroblast growth factor accelerates myelin debris clearance through activating autophagy to facilitate early peripheral nerve regeneration. J Cell Mol Med 25:2596\u20132608. https:\/\/doi.org\/10.1111\/jcmm.16274","journal-title":"J Cell Mol Med"},{"key":"3599_CR41","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s00401-017-1707-9","volume":"133","author":"T Guo","year":"2017","unstructured":"Guo T, Noble W, Hanger DP (2017) Roles of tau protein in health and disease. Acta Neuropathol 133:665\u2013704. https:\/\/doi.org\/10.1007\/s00401-017-1707-9","journal-title":"Acta Neuropathol"},{"key":"3599_CR42","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/bs.mcb.2017.06.006","volume":"141","author":"MB Trotter","year":"2017","unstructured":"Trotter MB, Stephens TD, McGrath JP, Steinhilb ML (2017) The Drosophila model system to study tau action. Methods Cell Biol 141:259\u2013286. https:\/\/doi.org\/10.1016\/bs.mcb.2017.06.006","journal-title":"Methods Cell Biol"},{"key":"3599_CR43","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/1741-7007-9-65","volume":"9","author":"F Parisi","year":"2011","unstructured":"Parisi F, Riccardo S, Daniel M, Saqcena M, Kundu N, Pession A, Grifoni D, Stocker H et al (2011) Drosophila insulin and target of rapamycin (TOR) pathways regulate GSK3 beta activity to control myc stability and determine myc expression in vivo. BMC Biol 9:65. https:\/\/doi.org\/10.1186\/1741-7007-9-65","journal-title":"BMC Biol"},{"key":"3599_CR44","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.jbior.2017.06.003","volume":"65","author":"MA Hermida","year":"2017","unstructured":"Hermida MA, Dinesh Kumar J, Leslie NR (2017) GSK3 and its interactions with the PI3K\/AKT\/mTOR signalling network. Adv Biol Regul 65:5\u201315. https:\/\/doi.org\/10.1016\/j.jbior.2017.06.003","journal-title":"Adv Biol Regul"},{"key":"3599_CR45","doi-asserted-by":"publisher","first-page":"2935","DOI":"10.1242\/jcs.03473","volume":"120","author":"CF Lin","year":"2007","unstructured":"Lin CF, Chen CL, Chiang CW, Jan MS, Huang WC, Lin YS (2007) GSK-3beta acts downstream of PP2A and the PI 3-kinase-akt pathway, and upstream of caspase-2 in ceramide-induced mitochondrial apoptosis. J Cell Sci 120:2935\u20132943. https:\/\/doi.org\/10.1242\/jcs.03473","journal-title":"J Cell Sci"},{"key":"3599_CR46","doi-asserted-by":"publisher","first-page":"e29782","DOI":"10.1371\/journal.pone.0029782","volume":"7","author":"SR Spindler","year":"2012","unstructured":"Spindler SR, Li R, Dhahbi JM, Yamakawa A, Sauer F (2012) Novel protein kinase signaling systems regulating lifespan identified by small molecule library screening using Drosophila. PLoS ONE 7:e29782. https:\/\/doi.org\/10.1371\/journal.pone.0029782","journal-title":"PLoS ONE"},{"key":"3599_CR47","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1159\/000324134","volume":"31","author":"D Cheng","year":"2011","unstructured":"Cheng D, Noble J, Tang MX, Schupf N, Mayeux R, Luchsinger JA (2011) Type 2 diabetes and late-onset Alzheimer\u2019s disease. Dement Geriatr Cogn Disord 31:424\u2013430. https:\/\/doi.org\/10.1159\/000324134","journal-title":"Dement Geriatr Cogn Disord"},{"key":"3599_CR48","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1111\/j.0954-6820.1983.tb03756.x","volume":"213","author":"G Bucht","year":"1983","unstructured":"Bucht G, Adolfsson R, Lithner F, Winblad B (1983) Changes in blood glucose and insulin secretion in patients with senile dementia of Alzheimer type. Acta Med Scand 213:387\u2013392. https:\/\/doi.org\/10.1111\/j.0954-6820.1983.tb03756.x","journal-title":"Acta Med Scand"},{"key":"3599_CR49","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neurobiolaging.2008.04.002","volume":"31","author":"AM Moloney","year":"2010","unstructured":"Moloney AM, Griffin RJ, Timmons S, O\u2019Connor R, Ravid R, O\u2019Neill C (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1\/2 in Alzheimer\u2019s disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 31:224\u2013243. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2008.04.002","journal-title":"Neurobiol Aging"},{"key":"3599_CR50","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3233\/jad-2005-7107","volume":"7","author":"E Steen","year":"2005","unstructured":"Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR et al (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer\u2019s disease\u2013is this type 3 diabetes? J Alzheimers Dis 7:63\u201380. https:\/\/doi.org\/10.3233\/jad-2005-7107","journal-title":"J Alzheimers Dis"},{"key":"3599_CR51","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3233\/jad-2010-100795","volume":"22","author":"FJ Gil-Bea","year":"2010","unstructured":"Gil-Bea FJ, Solas M, Solomon A, Mugueta C, Winblad B, Kivipelto M, Ramirez MJ, Cedazo-M\u00ednguez A (2010) Insulin levels are decreased in the cerebrospinal fluid of women with prodomal Alzheimer\u2019s disease. J Alzheimers Dis 22:405\u2013413. https:\/\/doi.org\/10.3233\/jad-2010-100795","journal-title":"J Alzheimers Dis"},{"key":"3599_CR52","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1038\/s42003-018-0253-x","volume":"2","author":"Y Huang","year":"2019","unstructured":"Huang Y, Wan Z, Wang Z, Zhou B (2019) Insulin signaling in Drosophila melanogaster mediates A\u03b2 toxicity. Commun Biol 2:13. https:\/\/doi.org\/10.1038\/s42003-018-0253-x","journal-title":"Commun Biol"},{"key":"3599_CR53","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1186\/s12916-020-01688-6","volume":"18","author":"H Kolb","year":"2020","unstructured":"Kolb H, Kempf K, R\u00f6hling M, Martin S (2020) Insulin: too much of a good thing is bad. BMC Med 18:224. https:\/\/doi.org\/10.1186\/s12916-020-01688-6","journal-title":"BMC Med"},{"key":"3599_CR54","doi-asserted-by":"publisher","first-page":"2257","DOI":"10.1084\/jem.20161731","volume":"214","author":"E Marciniak","year":"2017","unstructured":"Marciniak E, Leboucher A, Caron E, Ahmed T, Tailleux A, Dumont J, Issad T, Gerhardt E et al (2017) Tau deletion promotes brain insulin resistance. J Exp Med 214:2257\u20132269. https:\/\/doi.org\/10.1084\/jem.20161731","journal-title":"J Exp Med"},{"key":"3599_CR55","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1002\/mrd.22806","volume":"84","author":"D Das","year":"2017","unstructured":"Das D, Arur S (2017) Conserved insulin signaling in the regulation of oocyte growth, development, and maturation. Mol Reprod Dev 84:444\u2013459. https:\/\/doi.org\/10.1002\/mrd.22806","journal-title":"Mol Reprod Dev"},{"key":"3599_CR56","doi-asserted-by":"publisher","first-page":"4962","DOI":"10.1021\/bi00015a007","volume":"34","author":"T Yamaguchi","year":"1995","unstructured":"Yamaguchi T, Fernandez R, Roth RA (1995) Comparison of the signaling abilities of the Drosophila and human insulin receptors in mammalian cells. Biochemistry 34:4962\u20134968. https:\/\/doi.org\/10.1021\/bi00015a007","journal-title":"Biochemistry"},{"key":"3599_CR57","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1074\/jbc.m110.156018","volume":"286","author":"W Sajid","year":"2011","unstructured":"Sajid W, Kulahin N, Schluckebier G, Ribel U, Henderson HR, Tatar M, Hansen BF, Svendsen AM, Kiselyov VV, N\u00f8rgaard P, Wahlund PO, Brandt J, Kohanski RA, Andersen AS, De Meyts P (2011) Structural and biological properties of the Drosophila insulin-like peptide 5 show evolutionary conservation. J Biol Chem 286:661\u2013673. https:\/\/doi.org\/10.1074\/jbc.m110.156018","journal-title":"J Biol Chem"},{"key":"3599_CR58","doi-asserted-by":"publisher","first-page":"3373","DOI":"10.1002\/j.1460-2075.1995.tb07343.x","volume":"14","author":"R Fernandez","year":"1995","unstructured":"Fernandez R, Tabarini D, Azpiazu N, Frasch M, Schlessinger J (1995) The Drosophila insulin receptor homolog: a gene essential for embryonic development encodes two receptor isoforms with different signaling potential. EMBO J 14:3373\u20133384. https:\/\/doi.org\/10.1002\/j.1460-2075.1995.tb07343.x","journal-title":"EMBO J"},{"key":"3599_CR59","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/s0960-9822(01)00068-9","volume":"11","author":"W Brogiolo","year":"2001","unstructured":"Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, Hafen E (2001) An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11:213\u2013221. https:\/\/doi.org\/10.1016\/s0960-9822(01)00068-9","journal-title":"Curr Biol"},{"key":"3599_CR60","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1021\/acschembio.7b01039","volume":"13","author":"F Kundel","year":"2018","unstructured":"Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM et al (2018) Hsp70 inhibits the nucleation and elongation of tau and sequesters tau aggregates with High Affinity. ACS Chem Biol 13:636\u2013646. https:\/\/doi.org\/10.1021\/acschembio.7b01039","journal-title":"ACS Chem Biol"},{"key":"3599_CR61","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1007\/s11154-013-9272-6","volume":"15","author":"KH Kim","year":"2014","unstructured":"Kim KH, Lee MS (2014) Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism. Rev Endocr Metab Disord 15:11\u201320. https:\/\/doi.org\/10.1007\/s11154-013-9272-6","journal-title":"Rev Endocr Metab Disord"},{"key":"3599_CR62","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1007\/s11154-013-9272-6","volume":"65","author":"AM Tolkovsky","year":"2021","unstructured":"Tolkovsky AM, Spillantini MG (2021) Tau aggregation and its relation to selected forms of neuronal cell death. Essays Biochem 65:847\u2013857. https:\/\/doi.org\/10.1007\/s11154-013-9272-6","journal-title":"Essays Biochem"},{"key":"3599_CR63","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1111\/j.1749-6632.2010.05614.x","volume":"1201","author":"HS Jung","year":"2010","unstructured":"Jung HS, Lee MS (2010) Role of autophagy in diabetes and mitochondria. Ann N Y Acad Sci 1201:79\u201383. https:\/\/doi.org\/10.1111\/j.1749-6632.2010.05614.x","journal-title":"Ann N Y Acad Sci"},{"key":"3599_CR64","doi-asserted-by":"publisher","first-page":"2363","DOI":"10.1074\/jbc.m806088200","volume":"284","author":"JE Young","year":"2009","unstructured":"Young JE, Martinez RA, La Spada AR (2009) Nutrient deprivation induces neuronal autophagy and implicates reduced insulin signaling in neuroprotective autophagy activation. J Biol Chem 284:2363\u20132373. https:\/\/doi.org\/10.1074\/jbc.m806088200","journal-title":"J Biol Chem"},{"key":"3599_CR65","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1007\/s004010100423","volume":"103","author":"JC Augustinack","year":"2002","unstructured":"Augustinack JC, Schneider A, Mandelkow E-M, Hyman BT (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer\u2019s disease. Acta Neuropathol 103:26\u201335. https:\/\/doi.org\/10.1007\/s004010100423","journal-title":"Acta Neuropathol"},{"key":"3599_CR66","doi-asserted-by":"publisher","first-page":"55833","DOI":"10.1074\/jbc.m409954200","volume":"279","author":"A Schneider","year":"2004","unstructured":"Schneider A, Ara\u00fajo GW, Trajkovic K, Herrmann MM, Merkler D, Mandelkow EM, Weissert R, Simons M (2004) Hyperphosphorylation and aggregation of tau in experimental autoimmune encephalomyelitis. J Biol Chem 279:55833\u201355839. https:\/\/doi.org\/10.1074\/jbc.m409954200","journal-title":"J Biol Chem"},{"key":"3599_CR67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1242\/bio.20136692","volume":"3","author":"G Povellato","year":"2014","unstructured":"Povellato G, Tuxworth RI, Hanger DP, Tear G (2014) Modification of the Drosophila model of in vivo tau toxicity reveals protective phosphorylation by GSK3\u03b2. Biol Open 3:1\u201311. https:\/\/doi.org\/10.1242\/bio.20136692","journal-title":"Biol Open"},{"key":"3599_CR68","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.cell.2017.04.001","volume":"169","author":"BD Manning","year":"2017","unstructured":"Manning BD, Toker A (2017) AKT\/PKB signaling: navigating the network. Cell 169:381\u2013405. https:\/\/doi.org\/10.1016\/j.cell.2017.04.001","journal-title":"Cell"},{"key":"3599_CR69","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3233\/jad-150497","volume":"49","author":"D Chu","year":"2016","unstructured":"Chu D, Tan J, Xie S, Jin N, Yin X, Gong CX, Iqbal K, Liu F (2016) GSK-3\u03b2 is dephosphorylated by PP2A in a Leu309 methylation-independent manner. J Alzheimers Dis 49:365\u2013375. https:\/\/doi.org\/10.3233\/jad-150497","journal-title":"J Alzheimers Dis"},{"key":"3599_CR70","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.mce.2016.08.016","volume":"437","author":"M Beg","year":"2016","unstructured":"Beg M, Srivastava A, Shankar K, Varshney S, Rajan S, Gupta A, Kumar D, Gaikwad AN (2016) PPP2R5B, a regulatory subunit of PP2A, contributes to adipocyte insulin resistance. Mol Cell Endocrinol 437:97\u2013107. https:\/\/doi.org\/10.1016\/j.mce.2016.08.016","journal-title":"Mol Cell Endocrinol"},{"key":"3599_CR71","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.arr.2012.06.008","volume":"12","author":"L Martin","year":"2013","unstructured":"Martin L, Latypova X, Wilson CM, Magnaudeix A, Perrin ML, Terro F (2013) Tau protein phosphatases in Alzheimer\u2019s disease: the leading role of PP2A. Ageing Res Rev 12:39\u201349. https:\/\/doi.org\/10.1016\/j.arr.2012.06.008","journal-title":"Ageing Res Rev"},{"key":"3599_CR72","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1093\/jnen\/59.10.880","volume":"59","author":"X Zhu","year":"2000","unstructured":"Zhu X, Rottkamp CA, Boux H, Takeda A, Perry G, Smith MA (2000) Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease. J Neuropathol Exp Neurol 59:880\u2013888. https:\/\/doi.org\/10.1093\/jnen\/59.10.880","journal-title":"J Neuropathol Exp Neurol"},{"key":"3599_CR73","doi-asserted-by":"publisher","first-page":"e1002429","DOI":"10.1371\/journal.pgen.1002429","volume":"7","author":"W Zhang","year":"2011","unstructured":"Zhang W, Thompson BJ, Hietakangas V, Cohen SM (2011) MAPK\/ERK signaling regulates insulin sensitivity to control glucose metabolism in Drosophila. PLoS Genet 7:e1002429. https:\/\/doi.org\/10.1371\/journal.pgen.1002429","journal-title":"PLoS Genet"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03599-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03599-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03599-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T12:21:21Z","timestamp":1707740481000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03599-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,7]]},"references-count":73,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["3599"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03599-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,7]]},"assertion":[{"value":"4 April 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}]}}