{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:21:52Z","timestamp":1792783312708,"version":"4.5.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T00:00:00Z","timestamp":1693872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"the 2030 Plan Technology and Innovation of China","award":["2021ZD0200700"],"award-info":[{"award-number":["2021ZD0200700"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271535"],"award-info":[{"award-number":["82271535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Science and Technology Innovation Program of Hunan Province","award":["2022RC1008"],"award-info":[{"award-number":["2022RC1008"]}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["2021JJ40894"],"award-info":[{"award-number":["2021JJ40894"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004735","name":"Hunan Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["2022JJ30882"],"award-info":[{"award-number":["2022JJ30882"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["202103090528"],"award-info":[{"award-number":["202103090528"]}]},{"name":"Scientific Research Project of Hunan Provincial Health Commission","award":["202211004855"],"award-info":[{"award-number":["202211004855"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Accumulating evidence has suggested that the gut microbiome plays an important role in depression.\n                    <jats:italic>Akkermansia muciniphila<\/jats:italic>\n                    (AKK), a next-generation probiotic, shows a beneficial effect on immune and metabolic homeostasis. The relative abundance of AKK was found negatively correlated with depressive symptoms in both clinical and pre-clinical studies. To evaluate the potential antidepressant effect of AKK and explore the possible mechanism, we used chronic alcohol exposure and chronic unpredictable mild stress (CUMS) to induce depressive-like behaviors in mice. We found that oral AKK administration significantly reduced the immobility time in the force swimming test (FST) and tail suspension test (TST) in the mice with chronic alcohol exposure and the CUMS mice. The sucrose preference in the mice receiving AKK was significantly increased in the sucrose preference test (SPT). More importantly, AKK implantation significantly increased the level of 5-HT in the gut and PFC of both the alcohol exposure mice and the CUMS mice. Furthermore, AKK had inhibited the expression of SERT in the gut but not in the brain for both NIAAA and the CUMS model mice. Interestingly, the expression of cFos in enteric nerves in the gut significantly decreased after AKK administration. In conclusion, our study demonstrated the antidepressant effect of AKK in mice exposed to alcohol exposure and CUMS, with the potential mechanism that AKK implantation might lead to an increased level of 5-HT and inhibited SERT expression in the gut, and might alter the gut-to-brain signal through suppression of enteric nerves activation.\n                  <\/jats:p>","DOI":"10.1007\/s12035-023-03602-6","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T11:02:55Z","timestamp":1693911775000},"page":"821-834","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Akkermansia muciniphila Improves Depressive-Like Symptoms by Modulating the Level of 5-HT Neurotransmitters in the Gut and Brain of Mice"],"prefix":"10.1007","volume":"61","author":[{"given":"Huijuan","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinxu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6211-7576","authenticated-orcid":false,"given":"Xiaojie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,9,5]]},"reference":[{"issue":"21","key":"3602_CR1","first-page":"591","volume":"21","author":"F Edition","year":"2013","unstructured":"Edition F (2013) Diagnostic and statistical manual of mental disorders. Am Psychiatric Assoc 21(21):591\u2013643","journal-title":"Am Psychiatric Assoc"},{"key":"3602_CR2","unstructured":"Depression W (2017) Other common mental disorders: global health estimates. Geneva: World Health Organization 24"},{"issue":"2","key":"3602_CR3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","volume":"9","author":"GMD Collaborators","year":"2022","unstructured":"Collaborators GMD (2022) Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet Psychiatry 9(2):137\u2013150","journal-title":"The Lancet Psychiatry"},{"issue":"10128","key":"3602_CR4","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/s0140-6736(17)32802-7","volume":"391","author":"A Cipriani","year":"2018","unstructured":"Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG et al (2018) Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 391(10128):1357\u20131366. https:\/\/doi.org\/10.1016\/s0140-6736(17)32802-7","journal-title":"Lancet"},{"issue":"7","key":"3602_CR5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.5694\/mja2.50522","volume":"212","author":"J Rothmore","year":"2020","unstructured":"Rothmore J (2020) Antidepressant-induced sexual dysfunction. Med J Aust 212(7):329\u2013334. https:\/\/doi.org\/10.5694\/mja2.50522","journal-title":"Med J Aust"},{"key":"3602_CR6","doi-asserted-by":"publisher","first-page":"i65","DOI":"10.1136\/bmj.i65","volume":"352","author":"T Sharma","year":"2016","unstructured":"Sharma T, Guski LS, Freund N, G\u00f8tzsche PC (2016) Suicidality and aggression during antidepressant treatment: systematic review and meta-analyses based on clinical study reports. BMJ (Clinical research ed) 352:i65. https:\/\/doi.org\/10.1136\/bmj.i65","journal-title":"BMJ (Clinical research ed)"},{"issue":"6","key":"3602_CR7","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1007\/s11920-007-0061-3","volume":"9","author":"D Warden","year":"2007","unstructured":"Warden D, Rush AJ, Trivedi MH, Fava M, Wisniewski SR (2007) The STAR*D Project results: a comprehensive review of findings. Current Psychiatry Reports 9(6):449\u2013459. https:\/\/doi.org\/10.1007\/s11920-007-0061-3","journal-title":"Current Psychiatry Reports"},{"issue":"12","key":"3602_CR8","first-page":"34","volume":"23","author":"AR Ruelaz","year":"2006","unstructured":"Ruelaz AR (2006) Treatment-resistant depression: strategies for management. Psychiatric Times 23(12):34\u201334","journal-title":"Psychiatric Times"},{"key":"3602_CR9","doi-asserted-by":"publisher","unstructured":"Zhdanava M, Pilon D, Ghelerter I, Chow W, Joshi K, Lefebvre P, Sheehan JJ (2021) The prevalence and national burden of treatment-resistant depression and major depressive disorder in the United States. J Clin Psychiatry 82 (2). https:\/\/doi.org\/10.4088\/JCP.20m13699","DOI":"10.4088\/JCP.20m13699"},{"issue":"10159","key":"3602_CR10","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","volume":"392","author":"SL James","year":"2018","unstructured":"James SL, Abate D, Abate KH, Abay SM, Abbafati C, Abbasi N, Abbastabar H, Abd-Allah F (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. The Lancet 392(10159):1789\u20131858","journal-title":"The Lancet"},{"issue":"2","key":"3602_CR11","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1093\/alcalc\/agv088","volume":"51","author":"BL Odlaug","year":"2016","unstructured":"Odlaug BL, Gual A, DeCourcy J, Perry R, Pike J, Heron L, Rehm J (2016) Alcohol dependence, co-occurring conditions and attributable burden. Alcohol and alcoholism (Oxford, Oxfordshire) 51(2):201\u2013209. https:\/\/doi.org\/10.1093\/alcalc\/agv088","journal-title":"Alcohol and alcoholism (Oxford, Oxfordshire)"},{"issue":"6","key":"3602_CR12","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/acps.13034","volume":"139","author":"K G\u00e9mes","year":"2019","unstructured":"G\u00e9mes K, Forsell Y, Janszky I, L\u00e1szl\u00f3 KD, Lundin A, Ponce De Leon A, Mukamal KJ, Moller J (2019) Moderate alcohol consumption and depression - a longitudinal population-based study in Sweden. Acta Psychiatr Scand 139(6):526\u2013535. https:\/\/doi.org\/10.1111\/acps.13034","journal-title":"Acta Psychiatr Scand"},{"issue":"2","key":"3602_CR13","doi-asserted-by":"publisher","first-page":"365","DOI":"10.3892\/ijmm.2019.4436","volume":"45","author":"Y Yu","year":"2020","unstructured":"Yu Y, Xu D, Cheng S, Zhang L, Shi Z, Qin J, Zhang Z, Wang H (2020) Prenatal ethanol exposure enhances the susceptibility to depressive behavior of adult offspring rats fed a high-fat diet by affecting BDNF-associated pathway. Int J Mol Med 45(2):365\u2013374. https:\/\/doi.org\/10.3892\/ijmm.2019.4436","journal-title":"Int J Mol Med"},{"key":"3602_CR14","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01841-y","author":"H Yao","year":"2022","unstructured":"Yao H, Zhang D, Yu H, Yuan H, Shen H, Lan X, Liu H, Chen X et al (2022) Gut microbiota regulates chronic ethanol exposure-induced depressive-like behavior through hippocampal NLRP3-mediated neuroinflammation. Molecular Psychiatry. https:\/\/doi.org\/10.1038\/s41380-022-01841-y","journal-title":"Molecular Psychiatry"},{"key":"3602_CR15","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.pnpbp.2018.04.015","volume":"85","author":"T Hillemacher","year":"2018","unstructured":"Hillemacher T, Bachmann O, Kahl KG, Frieling H (2018) Alcohol, microbiome, and their effect on psychiatric disorders. Progress Neuro-Psychopharmacol Biol Psychiatry 85:105\u2013115. https:\/\/doi.org\/10.1016\/j.pnpbp.2018.04.015","journal-title":"Progress Neuro-Psychopharmacol Biol Psychiatry"},{"issue":"2","key":"3602_CR16","doi-asserted-by":"publisher","first-page":"108238","DOI":"10.1016\/j.celrep.2020.108238","volume":"33","author":"S Leclercq","year":"2020","unstructured":"Leclercq S, Le Roy T, Furgiuele S, Coste V, Bindels LB, Leyrolle Q, Neyrinck AM, Quoilin C et al (2020) Gut microbiota-induced changes in \u03b2-hydroxybutyrate metabolism are linked to altered sociability and depression in alcohol use disorder. Cell Reports 33(2):108238. https:\/\/doi.org\/10.1016\/j.celrep.2020.108238","journal-title":"Cell Reports"},{"key":"3602_CR17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1007\/978-981-32-9271-0_8","volume":"1180","author":"Y Ding","year":"2019","unstructured":"Ding Y, Dai J (2019) Advance in stress for depressive disorder. Adv Exp Med Biol 1180:147\u2013178. https:\/\/doi.org\/10.1007\/978-981-32-9271-0_8","journal-title":"Adv Exp Med Biol"},{"key":"3602_CR18","doi-asserted-by":"publisher","first-page":"115924","DOI":"10.1016\/j.taap.2022.115924","volume":"439","author":"H Yao","year":"2022","unstructured":"Yao H, Zhang D, Yu H, Shen H, Lan X, Liu H, Chen X, Wu X et al (2022) AMPAkine CX516 alleviated chronic ethanol exposure-induced neurodegeneration and depressive-like behavior in mice. Toxicol Appl Pharmacol 439:115924. https:\/\/doi.org\/10.1016\/j.taap.2022.115924","journal-title":"Toxicol Appl Pharmacol"},{"key":"3602_CR19","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.bbi.2020.07.015","volume":"91","author":"A Du Preez","year":"2021","unstructured":"Du Preez A, Onorato D, Eiben I, Musaelyan K, Egeland M, Zunszain PA, Fernandes C, Thuret S et al (2021) Chronic stress followed by social isolation promotes depressive-like behaviour, alters microglial and astrocyte biology and reduces hippocampal neurogenesis in male mice. Brain, Behavior, Immun 91:24\u201347. https:\/\/doi.org\/10.1016\/j.bbi.2020.07.015","journal-title":"Brain, Behavior, Immun"},{"key":"3602_CR20","doi-asserted-by":"publisher","first-page":"103908","DOI":"10.1016\/j.ebiom.2022.103908","volume":"77","author":"L Liu","year":"2022","unstructured":"Liu L, Huh JR, Shah K (2022) Microbiota and the gut-brain-axis: implications for new therapeutic design in the CNS. EBioMedicine 77:103908. https:\/\/doi.org\/10.1016\/j.ebiom.2022.103908","journal-title":"EBioMedicine"},{"key":"3602_CR21","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1146\/annurev-pharmtox-010919-023628","volume":"60","author":"C Long-Smith","year":"2020","unstructured":"Long-Smith C, O\u2019Riordan KJ, Clarke G, Stanton C, Dinan TG, Cryan JF (2020) Microbiota-gut-brain axis: new therapeutic opportunities. Annu Rev Pharmacol Toxicol 60:477\u2013502. https:\/\/doi.org\/10.1146\/annurev-pharmtox-010919-023628","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3602_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/j.jad.2020.09.010","volume":"278","author":"W-t Lai","year":"2021","unstructured":"Lai W-t, Zhao J, Xu S-x, Deng W-f, Xu D, Wang M-b, He F-s, Liu Y-h et al (2021) Shotgun metagenomics reveals both taxonomic and tryptophan pathway differences of gut microbiota in bipolar disorder with current major depressive episode patients. J Affect Disord 278:311\u2013319","journal-title":"J Affect Disord"},{"key":"3602_CR23","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.copbio.2014.10.007","volume":"32","author":"RA Luna","year":"2015","unstructured":"Luna RA, Foster JA (2015) Gut brain axis: diet microbiota interactions and implications for modulation of anxiety and depression. Curr Opinion Biotechnol 32:35\u201341. https:\/\/doi.org\/10.1016\/j.copbio.2014.10.007","journal-title":"Curr Opinion Biotechnol"},{"key":"3602_CR24","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jpsychires.2016.07.019","volume":"82","author":"JR Kelly","year":"2016","unstructured":"Kelly JR, Borre Y, O\u2019Brien C, Patterson E, El Aidy S, Deane J, Kennedy PJ, Beers S et al (2016) Transferring the blues: depression-associated gut microbiota induces neurobehavioural changes in the rat. J Psychiatr Res 82:109\u2013118","journal-title":"J Psychiatr Res"},{"issue":"38","key":"3602_CR25","doi-asserted-by":"publisher","first-page":"16050","DOI":"10.1073\/pnas.1102999108","volume":"108","author":"JA Bravo","year":"2011","unstructured":"Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Nat Acad Sci 108(38):16050\u201316055","journal-title":"Proc Nat Acad Sci"},{"issue":"2","key":"3602_CR26","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.jpsychires.2008.03.009","volume":"43","author":"L Desbonnet","year":"2008","unstructured":"Desbonnet L, Garrett L, Clarke G, Bienenstock J, Dinan TG (2008) The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J Psychiatric Res 43(2):164\u2013174","journal-title":"J Psychiatric Res"},{"issue":"1","key":"3602_CR27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-016-0028-x","volume":"7","author":"C Yang","year":"2017","unstructured":"Yang C, Fujita Y, Ren Q, Ma M, Dong C, Hashimoto K (2017) Bifidobacterium in the gut microbiota confer resilience to chronic social defeat stress in mice. Sci Rep 7(1):1\u20137","journal-title":"Sci Rep"},{"key":"3602_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.bbi.2017.05.011","volume":"65","author":"A Moya-P\u00e9rez","year":"2017","unstructured":"Moya-P\u00e9rez A, Perez-Villalba A, Benitez-Paez A, Campillo I, Sanz Y (2017) Bifidobacterium CECT 7765 modulates early stress-induced immune, neuroendocrine and behavioral alterations in mice. Brain, Behavior, Immun 65:43\u201356","journal-title":"Brain, Behavior, Immun"},{"issue":"31","key":"3602_CR29","doi-asserted-by":"publisher","first-page":"8415","DOI":"10.1021\/acs.jafc.8b02462","volume":"66","author":"J Sun","year":"2018","unstructured":"Sun J, Wang F, Hu X, Yang C, Xu H, Yao Y, Liu J (2018) Clostridium butyricum attenuates chronic unpredictable mild stress-induced depressive-like behavior in mice via the gut-brain axis. J Agric Food Chem 66(31):8415\u20138421","journal-title":"J Agric Food Chem"},{"key":"3602_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2022.05.003","author":"P Tian","year":"2022","unstructured":"Tian P, Zou R, Wang L, Chen Y, Qian X, Zhao J, Zhang H, Qian L et\u00a0 al (2022) Multi-probiotics ameliorate major depressive disorder and accompanying gastrointestinal syndromes via serotonergic system regulation. J Adv Res. https:\/\/doi.org\/10.1016\/j.jare.2022.05.003","journal-title":"J Adv Res"},{"issue":"4","key":"3602_CR31","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1038\/s41564-018-0337-x","volume":"4","author":"M Valles-Colomer","year":"2019","unstructured":"Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, Schiweck C, Kurilshikov A et al (2019) The neuroactive potential of the human gut microbiota in quality of life and depression. Nature microbiology 4(4):623\u2013632","journal-title":"Nature microbiology"},{"key":"3602_CR32","doi-asserted-by":"publisher","first-page":"541","DOI":"10.3389\/fpsyt.2020.00541","volume":"11","author":"ZA Barandouzi","year":"2020","unstructured":"Barandouzi ZA, Starkweather AR, Henderson WA, Gyamfi A, Cong XS (2020) Altered composition of gut microbiota in depression: a systematic review. Front Psychiatry 11:541. https:\/\/doi.org\/10.3389\/fpsyt.2020.00541","journal-title":"Front Psychiatry"},{"issue":"5","key":"3602_CR33","doi-asserted-by":"publisher","first-page":"1646","DOI":"10.1128\/AEM.01226-07","volume":"74","author":"M Derrien","year":"2008","unstructured":"Derrien M, Collado MC, Ben-Amor K, Salminen S, de Vos WM (2008) The Mucin degrader Akkermansia muciniphila is an abundant resident of the human intestinal tract. Appl Environ Microbiol 74(5):1646\u20131648","journal-title":"Appl Environ Microbiol"},{"issue":"7","key":"3602_CR34","doi-asserted-by":"publisher","first-page":"1096","DOI":"10.1038\/s41591-019-0495-2","volume":"25","author":"C Depommier","year":"2019","unstructured":"Depommier C, Everard A, Druart C, Plovier H, Van Hul M, Vieira-Silva S, Falony G, Raes J et al (2019) Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study. Nature medicine 25(7):1096\u20131103. https:\/\/doi.org\/10.1038\/s41591-019-0495-2","journal-title":"Nature medicine"},{"issue":"22","key":"3602_CR35","doi-asserted-by":"publisher","first-page":"9066","DOI":"10.1073\/pnas.1219451110","volume":"110","author":"A Everard","year":"2013","unstructured":"Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, Guiot Y, Derrien M et al (2013) Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proc Natl Acad Sci 110(22):9066\u20139071","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"3602_CR36","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1136\/gutjnl-2012-303839","volume":"63","author":"N-R Shin","year":"2014","unstructured":"Shin N-R, Lee J-C, Lee H-Y, Kim M-S, Whon TW, Lee M-S, Bae J-W (2014) An increase in the Akkermansia spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice. Gut 63(5):727\u2013735","journal-title":"Gut"},{"issue":"1","key":"3602_CR37","doi-asserted-by":"publisher","first-page":"3281","DOI":"10.1038\/s41598-019-40140-5","volume":"9","author":"KD McGaughey","year":"2019","unstructured":"McGaughey KD, Yilmaz-Swenson T, Elsayed NM, Cruz DA, Rodriguiz RM, Kritzer MD, Peterchev AV, Roach J et al (2019) Relative abundance of Akkermansia spp. and other bacterial phylotypes correlates with anxiety- and depressive-like behavior following social defeat in mice. Scientific Reports 9(1):3281. https:\/\/doi.org\/10.1038\/s41598-019-40140-5","journal-title":"Scientific Reports"},{"issue":"7770","key":"3602_CR38","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/s41586-019-1443-5","volume":"572","author":"E Blacher","year":"2019","unstructured":"Blacher E, Bashiardes S, Shapiro H, Rothschild D, Mor U, Dori-Bachash M, Kleimeyer C, Moresi C, Harnik Y et al (2019) Potential roles of gut microbiome and metabolites in modulating ALS in mice. Nature 572(7770):474\u2013480. https:\/\/doi.org\/10.1038\/s41586-019-1443-5","journal-title":"Nature"},{"issue":"10","key":"3602_CR39","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1016\/j.jalz.2019.07.002","volume":"15","author":"B Li","year":"2019","unstructured":"Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q et al (2019) Mild cognitive impairment has similar alterations as Alzheimer\u2019s disease in gut microbiota. Alzheimer\u2019s Dementia 15(10):1357\u20131366. https:\/\/doi.org\/10.1016\/j.jalz.2019.07.002","journal-title":"Alzheimer\u2019s Dementia"},{"issue":"18","key":"3602_CR40","doi-asserted-by":"publisher","first-page":"6718","DOI":"10.1128\/aem.05212-11","volume":"77","author":"L Wang","year":"2011","unstructured":"Wang L, Christophersen CT, Sorich MJ, Gerber JP, Angley MT, Conlon MA (2011) Low relative abundances of the mucolytic bacterium Akkermansia muciniphila and Bifidobacterium spp. in feces of children with autism. Appl Environ Microbiol 77(18):6718\u20136721. https:\/\/doi.org\/10.1128\/aem.05212-11","journal-title":"Appl Environ Microbiol"},{"issue":"9","key":"3602_CR41","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1038\/nrgastro.2011.134","volume":"8","author":"J Altamirano","year":"2011","unstructured":"Altamirano J, Bataller R (2011) Alcoholic liver disease: pathogenesis and new targets for therapy. Nat Rev Gastroenterol Hepatol 8(9):491\u2013501","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"3","key":"3602_CR42","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1038\/nprot.2013.032","volume":"8","author":"A Bertola","year":"2013","unstructured":"Bertola A, Mathews S, Ki SH, Wang H, Gao B (2013) Mouse model of chronic and binge ethanol feeding (the NIAAA model). Nature Protocols 8(3):627\u2013637","journal-title":"Nature Protocols"},{"issue":"6","key":"3602_CR43","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1080\/10520295.2017.1323276","volume":"92","author":"SS Ali","year":"2017","unstructured":"Ali SS, Abd El Wahab MG, Ayuob NN, Suliaman M (2017) The antidepressant-like effect of Ocimum basilicum in an animal model of depression. Biotechnic Histochemistry 92(6):390\u2013401. https:\/\/doi.org\/10.1080\/10520295.2017.1323276","journal-title":"Biotechnic Histochemistry"},{"key":"3602_CR44","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.bbrc.2021.06.018","volume":"566","author":"R Cheng","year":"2021","unstructured":"Cheng R, Xu W, Wang J, Tang Z, Zhang M (2021) The outer membrane protein Amuc_1100 of Akkermansia muciniphila alleviates the depression-like behavior of depressed mice induced by chronic stress. Biochem Biophys Res Commun 566:170\u2013176. https:\/\/doi.org\/10.1016\/j.bbrc.2021.06.018","journal-title":"Biochem Biophys Res Commun"},{"key":"3602_CR45","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.ynstr.2016.08.001","volume":"6","author":"P Willner","year":"2017","unstructured":"Willner P (2017) Reliability of the chronic mild stress model of depression: a user survey. Neurobiol Stress 6:68\u201377","journal-title":"Neurobiol Stress"},{"issue":"11","key":"3602_CR46","doi-asserted-by":"publisher","first-page":"7588","DOI":"10.1039\/c9fo01630a","volume":"10","author":"P Tian","year":"2019","unstructured":"Tian P, Zou R, Song L, Zhang X, Jiang B, Wang G, Lee YK, Zhao J et al (2019) Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota. Food Function 10(11):7588\u20137598. https:\/\/doi.org\/10.1039\/c9fo01630a","journal-title":"Food Function"},{"key":"3602_CR47","doi-asserted-by":"publisher","first-page":"113387","DOI":"10.1016\/j.physbeh.2021.113387","volume":"234","author":"H Yao","year":"2021","unstructured":"Yao H, Shen H, Yu H, Wang C, Ding R, Lan X, Tash D, Wu X et al (2021) Chronic ethanol exposure induced depressive-like behavior in male C57BL\/6 N mice by downregulating GluA1. Physiol Behavior 234:113387. https:\/\/doi.org\/10.1016\/j.physbeh.2021.113387","journal-title":"Physiol Behavior"},{"issue":"5","key":"3602_CR48","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1136\/gutjnl-2016-313432","volume":"67","author":"C Grander","year":"2018","unstructured":"Grander C, Adolph TE, Wieser V, Lowe P, Wrzosek L, Gyongyosi B, Ward DV, Grabherr F et al (2018) Recovery of ethanol-induced Akkermansia muciniphila depletion ameliorates alcoholic liver disease. Gut 67(5):891\u2013901. https:\/\/doi.org\/10.1136\/gutjnl-2016-313432","journal-title":"Gut"},{"key":"3602_CR49","doi-asserted-by":"publisher","unstructured":"Yankelevitch-Yahav R, Franko M, Huly A, Doron R (2015) The forced swim test as a model of depressive-like behavior. Journal of visualized experiments : JoVE (97). https:\/\/doi.org\/10.3791\/52587","DOI":"10.3791\/52587"},{"issue":"6","key":"3602_CR50","doi-asserted-by":"publisher","first-page":"e00316","DOI":"10.1016\/j.heliyon.2017.e00316","volume":"3","author":"K Hiraoka","year":"2017","unstructured":"Hiraoka K, Motomura K, Yanagida S, Ohashi A, Ishisaka-Furuno N, Kanba S (2017) Pattern of c-Fos expression induced by tail suspension test in the mouse brain. Heliyon 3(6):e00316","journal-title":"Heliyon"},{"issue":"1","key":"3602_CR51","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1037\/h0073676","volume":"17","author":"CS Hall","year":"1934","unstructured":"Hall CS (1934) Drive and emotionality: factors associated with adjustment in the rat. J Comp Psychol 17(1):89","journal-title":"J Comp Psychol"},{"issue":"21\u201322","key":"3602_CR52","doi-asserted-by":"publisher","first-page":"8411","DOI":"10.1007\/s00253-021-11622-2","volume":"105","author":"Y Ding","year":"2021","unstructured":"Ding Y, Bu F, Chen T, Shi G, Yuan X, Feng Z, Duan Z, Wang R et al (2021) A next-generation probiotic: Akkermansia muciniphila ameliorates chronic stress-induced depressive-like behavior in mice by regulating gut microbiota and metabolites. Appl Microbiol Biotechnol 105(21\u201322):8411\u20138426. https:\/\/doi.org\/10.1007\/s00253-021-11622-2","journal-title":"Appl Microbiol Biotechnol"},{"issue":"3","key":"3602_CR53","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1002\/j.2051-5545.2010.tb00298.x","volume":"9","author":"G Hasler","year":"2010","unstructured":"Hasler G (2010) Pathophysiology of depression: do we have any solid evidence of interest to clinicians? World Psychiatry 9(3):155","journal-title":"World Psychiatry"},{"key":"3602_CR54","doi-asserted-by":"publisher","first-page":"126","DOI":"10.3389\/fncel.2017.00126","volume":"11","author":"Y-J Liu","year":"2017","unstructured":"Liu Y-J, Tsai P-Y, Chern Y (2017) Energy homeostasis and abnormal RNA metabolism in amyotrophic lateral sclerosis. Front Cell Neurosci 11:126","journal-title":"Front Cell Neurosci"},{"issue":"6","key":"3602_CR55","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/mp.2012.77","volume":"18","author":"G Clarke","year":"2013","unstructured":"Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, Dinan TG, Cryan JF (2013) The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Molecular Psychiatry 18(6):666\u2013673. https:\/\/doi.org\/10.1038\/mp.2012.77","journal-title":"Molecular Psychiatry"},{"issue":"2","key":"3602_CR56","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1111\/j.1476-5381.2011.01557.x","volume":"165","author":"FE O'Brien","year":"2012","unstructured":"O\u2019Brien FE, Dinan TG, Griffin BT, Cryan JF (2012) Interactions between antidepressants and P-glycoprotein at the blood-brain barrier: clinical significance of in vitro and in vivo findings. Br J Pharmacol 165(2):289\u2013312. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01557.x","journal-title":"Br J Pharmacol"},{"issue":"2","key":"3602_CR57","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1038\/nrn1846","volume":"7","author":"O Berton","year":"2006","unstructured":"Berton O, Nestler EJ (2006) New approaches to antidepressant drug discovery: beyond monoamines. Nat Rev Neurosci 7(2):137\u2013151","journal-title":"Nat Rev Neurosci"},{"issue":"7816","key":"3602_CR58","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1038\/s41586-020-2474-7","volume":"583","author":"PA Muller","year":"2020","unstructured":"Muller PA, Schneeberger M, Matheis F, Wang P, Kerner Z, Ilanges A, Pellegrino K, Del M\u00e1rmol J et al (2020) Microbiota modulate sympathetic neurons via a gut-brain circuit. Nature 583(7816):441\u2013446. https:\/\/doi.org\/10.1038\/s41586-020-2474-7","journal-title":"Nature"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03602-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03602-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03602-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,12]],"date-time":"2024-02-12T07:21:00Z","timestamp":1707722460000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03602-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,5]]},"references-count":58,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["3602"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03602-6","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,5]]},"assertion":[{"value":"8 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 August 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The protocol of the study was approved by the Animal Care and Use Committee of the Second Xiangya Hospital of Central South University and was in accordance with the institution\u2019s guidelines for the care and use of laboratory animals.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}