{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:43:30Z","timestamp":1774637010324,"version":"3.50.1"},"reference-count":78,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Taiwan National Science and Technology Council","award":["MOST-110-2314-B-037-095"],"award-info":[{"award-number":["MOST-110-2314-B-037-095"]}]},{"name":"Taiwan National Science and Technology Council","award":["MOST-111-2314-B-037-097"],"award-info":[{"award-number":["MOST-111-2314-B-037-097"]}]},{"name":"Kaohsiung Medical University Hospital","award":["KMUH111-1R23"],"award-info":[{"award-number":["KMUH111-1R23"]}]},{"DOI":"10.13039\/501100011913","name":"Kaohsiung Veterans General Hospital","doi-asserted-by":"publisher","award":["KSVGH 112-102"],"award-info":[{"award-number":["KSVGH 112-102"]}],"id":[{"id":"10.13039\/501100011913","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Kaohsiung Medical University Research Center Grant","award":["KMU-TC111B05"],"award-info":[{"award-number":["KMU-TC111B05"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1007\/s12035-023-03660-w","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T04:02:10Z","timestamp":1695960130000},"page":"1714-1725","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["RTA-408 Regulates p-NF-\u03baB\/TSLP\/STAT5 Signaling to Ameliorate Nociceptive Hypersensitivity in Chronic Constriction Injury Rats"],"prefix":"10.1007","volume":"61","author":[{"given":"Ying-Yi","family":"Lu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hung-Pei","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tai-Hsin","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hsiao-Chien","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi-Hao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5116-8004","authenticated-orcid":false,"given":"Chieh-Hsin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"issue":"2","key":"3660_CR1","first-page":"512","volume":"23","author":"LA Zilliox","year":"2017","unstructured":"Zilliox LA (2017) Neuropathic pain. Continuum (Minneap Minn) 23(2):512\u2013532","journal-title":"Continuum (Minneap Minn)"},{"key":"3660_CR2","doi-asserted-by":"publisher","first-page":"17002","DOI":"10.1038\/nrdp.2017.2","volume":"3","author":"L Colloca","year":"2017","unstructured":"Colloca L, Ludman T, Bouhassira D, Baron R, Dickenson AH, Yarnitsky D, Freeman R, Truini A et al (2017) Neuropathic pain. Nat Rev Dis Primers 3:17002","journal-title":"Nat Rev Dis Primers"},{"issue":"12","key":"3660_CR3","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.2165\/11596280-000000000-00000","volume":"25","author":"Y Vorobeychik","year":"2011","unstructured":"Vorobeychik Y, Gordin V, Mao J, Chen L (2011) Combination therapy for neuropathic pain: a review of current evidence. CNS Drugs 25(12):1023\u20131034","journal-title":"CNS Drugs"},{"issue":"10","key":"3660_CR4","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1302\/0301-620X.90B10.20910","volume":"90","author":"AG Hadjipavlou","year":"2008","unstructured":"Hadjipavlou AG, Tzermiadianos MN, Bogduk N, Zindrick MR (2008) The pathophysiology of disc degeneration: a critical review. J Bone Joint Surg Br 90(10):1261\u20131270","journal-title":"J Bone Joint Surg Br"},{"issue":"3","key":"3660_CR5","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3171\/SPI\/2008\/9\/9\/285","volume":"9","author":"Y Kokubo","year":"2008","unstructured":"Kokubo Y, Uchida K, Kobayashi S, Yayama T, Sato R, Nakajima H, Takamura T, Mwaka E et al (2008) Herniated and spondylotic intervertebral discs of the human cervical spine: histological and immunohistological findings in 500 en bloc surgical samples. Laboratory investigation. J Neurosurg Spine 9(3):285\u2013295","journal-title":"J Neurosurg Spine"},{"issue":"23","key":"3660_CR6","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1097\/00007632-199812010-00008","volume":"23","author":"K Olmarker","year":"1998","unstructured":"Olmarker K, Larsson K (1998) Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine (Phila Pa 1976) 23(23):2538\u20132544","journal-title":"Spine (Phila Pa 1976)"},{"key":"3660_CR7","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/1744-8069-7-57","volume":"7","author":"MK Lee","year":"2011","unstructured":"Lee MK, Han SR, Park MK, Kim MJ, Bae YC, Kim SK, Park JS, Ahn DK (2011) Behavioral evidence for the differential regulation of p-p38 MAPK and p-NF-kappaB in rats with trigeminal neuropathic pain. Mol Pain 7:57","journal-title":"Mol Pain"},{"issue":"2","key":"3660_CR8","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3390\/ijms18020287","volume":"18","author":"MJ Barton","year":"2017","unstructured":"Barton MJ, John JS, Clarke M, Wright A, Ekberg J (2017) The glia response after peripheral nerve injury: a comparison between Schwann cells and olfactory ensheathing cells and their uses for neural regenerative therapies. Int J Mol Sci 18(2):287","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3660_CR9","doi-asserted-by":"publisher","first-page":"1483","DOI":"10.1016\/j.freeradbiomed.2005.10.066","volume":"40","author":"HJ Kim","year":"2006","unstructured":"Kim HJ, Chang EJ, Kim HM, Lee SB, Kim HD, Su Kim G, Kim HH (2006) Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med 40(9):1483\u20131493","journal-title":"Free Radic Biol Med"},{"key":"3660_CR10","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbi.2015.07.014","volume":"50","author":"JE Hartung","year":"2015","unstructured":"Hartung JE, Eskew O, Wong T, Tchivileva IE, Oladosu FA, O\u2019Buckley SC, Nackley AG (2015) Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation. Brain Behav Immun 50:196\u2013202","journal-title":"Brain Behav Immun"},{"issue":"3","key":"3660_CR11","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1172\/JCI11916","volume":"107","author":"MP Mattson","year":"2001","unstructured":"Mattson MP, Camandola S (2001) NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest 107(3):247\u2013254","journal-title":"J Clin Invest"},{"issue":"48","key":"3660_CR12","doi-asserted-by":"publisher","first-page":"12775","DOI":"10.1523\/JNEUROSCI.3512-08.2008","volume":"28","author":"K Miyoshi","year":"2008","unstructured":"Miyoshi K, Obata K, Kondo T, Okamura H, Noguchi K (2008) Interleukin-18-mediated microglia\/astrocyte interaction in the spinal cord enhances neuropathic pain processing after nerve injury. J Neurosci 28(48):12775\u201312787","journal-title":"J Neurosci"},{"issue":"10","key":"3660_CR13","doi-asserted-by":"publisher","first-page":"5795","DOI":"10.1073\/pnas.95.10.5795","volume":"95","author":"KT Akama","year":"1998","unstructured":"Akama KT, Albanese C, Pestell RG, Van Eldik LJ (1998) Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism. Proc Natl Acad Sci U S A 95(10):5795\u20135800","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"25","key":"3660_CR14","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1097\/01.brs.0000248424.46652.67","volume":"31","author":"G Inoue","year":"2006","unstructured":"Inoue G, Ochiai N, Ohtori S, Nakagawa K, Gemba T, Doya H, Ito T, Koshi T et al (2006) Injection of nuclear factor-kappa B decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model. Spine (Phila Pa 1976) 31(25):2904\u20132908","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"3660_CR15","doi-asserted-by":"publisher","first-page":"1977","DOI":"10.1111\/j.1460-9568.2005.04379.x","volume":"22","author":"A Ledeboer","year":"2005","unstructured":"Ledeboer A, Gamanos M, Lai W, Martin D, Maier SF, Watkins LR, Quan N (2005) Involvement of spinal cord nuclear factor kappaB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci 22(8):1977\u20131986","journal-title":"Eur J Neurosci"},{"issue":"4","key":"3660_CR16","doi-asserted-by":"publisher","first-page":"1046","DOI":"10.3892\/etm.2021.10479","volume":"22","author":"W Shan","year":"2021","unstructured":"Shan W, Liao X, Tang Y, Liu J (2021) Dexmedetomidine alleviates inflammation in neuropathic pain by suppressing NLRP3 via Nrf2 activation. Exp Ther Med 22(4):1046","journal-title":"Exp Ther Med"},{"issue":"12","key":"3660_CR17","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1007\/s12035-022-03024-w","volume":"59","author":"OS Zaki","year":"2022","unstructured":"Zaki OS, Nassar NN, Abdallah DM, Safar MM, Mohammed RA (2022) Cilostazol alleviates NLRP3 inflammasome-induced allodynia\/hyperalgesia in murine cerebral cortex following transient ischemia: focus on TRPA1\/glutamate and Akt\/dopamine\/BDNF\/Nrf2 trajectories. Mol Neurobiol 59(12):7194\u20137211","journal-title":"Mol Neurobiol"},{"issue":"1","key":"3660_CR18","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/med.21726","volume":"41","author":"O Pol","year":"2021","unstructured":"Pol O (2021) The role of carbon monoxide, heme oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids. Med Res Rev 41(1):136\u2013155","journal-title":"Med Res Rev"},{"issue":"31","key":"3660_CR19","doi-asserted-by":"publisher","first-page":"eabo5633","DOI":"10.1126\/sciadv.abo5633","volume":"8","author":"C Vasavda","year":"2022","unstructured":"Vasavda C, Xu R, Liew J, Kothari R, Dhindsa RS, Semenza ER, Paul BD, Green DP et al (2022) Identification of the NRF2 transcriptional network as a therapeutic target for trigeminal neuropathic pain. Sci Adv 8(31):eabo5633","journal-title":"Sci Adv"},{"issue":"4","key":"3660_CR20","doi-asserted-by":"publisher","first-page":"159","DOI":"10.5487\/TR.2009.25.4.159","volume":"25","author":"J Kim","year":"2009","unstructured":"Kim J, Surh YJ (2009) The role of Nrf2 in cellular innate immune response to inflammatory injury. Toxicol Res 25(4):159\u2013173","journal-title":"Toxicol Res"},{"key":"3660_CR21","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1146\/annurev.pharmtox.46.120604.141046","volume":"47","author":"TW Kensler","year":"2007","unstructured":"Kensler TW, Wakabayashi N, Biswal S (2007) Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89\u2013116","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"3660_CR22","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1124\/pr.107.07104","volume":"60","author":"NG Abraham","year":"2008","unstructured":"Abraham NG, Kappas A (2008) Pharmacological and clinical aspects of heme oxygenase. Pharmacol Rev 60(1):79\u2013127","journal-title":"Pharmacol Rev"},{"issue":"8","key":"3660_CR23","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1038\/s41401-020-0394-6","volume":"41","author":"YQ Zhou","year":"2020","unstructured":"Zhou YQ, Liu DQ, Chen SP, Chen N, Sun J, Wang XM, Cao F, Tian YK et al (2020) Nrf2 activation ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain. Acta Pharmacol Sin 41(8):1041\u20131048","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"3660_CR24","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1007\/s13311-019-00784-7","volume":"17","author":"L Zhou","year":"2020","unstructured":"Zhou L, Ao L, Yan Y, Li C, Li W, Ye A, Liu J, Hu Y et al (2020) Levo-corydalmine attenuates vincristine-induced neuropathic pain in mice by upregulating the Nrf2\/HO-1\/CO pathway to inhibit connexin 43 expression. Neurotherapeutics 17(1):340\u2013355","journal-title":"Neurotherapeutics"},{"issue":"8","key":"3660_CR25","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.kjms.2018.03.005","volume":"34","author":"FB Feng","year":"2018","unstructured":"Feng FB, Qiu HY (2018) Neuroprotective effect of tanshinone IIA against neuropathic pain in diabetic rats through the Nrf2\/ARE and NF-kappaB signaling pathways. Kaohsiung J Med Sci 34(8):428\u2013437","journal-title":"Kaohsiung J Med Sci"},{"issue":"5","key":"3660_CR26","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1007\/s00403-013-1433-7","volume":"306","author":"SA Reisman","year":"2014","unstructured":"Reisman SA, Lee CY, Meyer CJ, Proksch JW, Ward KW (2014) Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin. Arch Dermatol Res 306(5):447\u2013454","journal-title":"Arch Dermatol Res"},{"key":"3660_CR27","doi-asserted-by":"publisher","first-page":"7612182","DOI":"10.1155\/2017\/7612182","volume":"2017","author":"P Han","year":"2017","unstructured":"Han P, Qin Z, Tang J, Xu Z, Li R, Jiang X, Yang C, Xing Q et al (2017) RTA-408 protects kidney from ischemia-reperfusion injury in mice via activating Nrf2 and downstream GSH biosynthesis gene. Oxid Med Cell Longev 2017:7612182","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"3660_CR28","doi-asserted-by":"publisher","first-page":"e01918","DOI":"10.1002\/brb3.1918","volume":"11","author":"L Zhang","year":"2021","unstructured":"Zhang L, Zhou Q, Zhou CL (2021) RTA-408 protects against propofol-induced cognitive impairment in neonatal mice via the activation of Nrf2 and the inhibition of NF-kappaB p65 nuclear translocation. Brain Behav 11(1):e01918","journal-title":"Brain Behav"},{"issue":"5","key":"3660_CR29","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1667\/RR13578.1","volume":"181","author":"SA Reisman","year":"2014","unstructured":"Reisman SA, Lee CY, Meyer CJ, Proksch JW, Sonis ST, Ward KW (2014) Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiat Res 181(5):512\u2013520","journal-title":"Radiat Res"},{"issue":"3","key":"3660_CR30","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1021\/np100826q","volume":"74","author":"MB Sporn","year":"2011","unstructured":"Sporn MB, Liby KT, Yore MM, Fu L, Lopchuk JM, Gribble GW (2011) New synthetic triterpenoids: potent agents for prevention and treatment of tissue injury caused by inflammatory and oxidative stress. J Nat Prod 74(3):537\u2013545","journal-title":"J Nat Prod"},{"issue":"1","key":"3660_CR31","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.freeradbiomed.2011.03.027","volume":"51","author":"A Neymotin","year":"2011","unstructured":"Neymotin A, Calingasan NY, Wille E, Naseri N, Petri S, Damiano M, Liby KT, Risingsong R et al (2011) Neuroprotective effect of Nrf2\/ARE activators, CDDO ethylamide and CDDO trifluoroethylamide, in a mouse model of amyotrophic lateral sclerosis. Free Radic Biol Med 51(1):88\u201396","journal-title":"Free Radic Biol Med"},{"issue":"6","key":"3660_CR32","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1093\/carcin\/bgp100","volume":"30","author":"MS Yates","year":"2009","unstructured":"Yates MS, Tran QT, Dolan PM, Osburn WO, Shin S, McCulloch CC, Silkworth JB, Taguchi K et al (2009) Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. Carcinogenesis 30(6):1024\u20131031","journal-title":"Carcinogenesis"},{"issue":"6","key":"3660_CR33","doi-asserted-by":"publisher","first-page":"1828","DOI":"10.1158\/1078-0432.CCR-05-2044","volume":"12","author":"S Shishodia","year":"2006","unstructured":"Shishodia S, Sethi G, Konopleva M, Andreeff M, Aggarwal BB (2006) A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells. Clin Cancer Res 12(6):1828\u20131838","journal-title":"Clin Cancer Res"},{"issue":"1","key":"3660_CR34","doi-asserted-by":"publisher","first-page":"9886","DOI":"10.1038\/s41598-017-06907-4","volume":"7","author":"HJ Wei","year":"2017","unstructured":"Wei HJ, Pareek TK, Liu Q, Letterio JJ (2017) A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA (RTA-408) is protective against EAE. Sci Rep 7(1):9886","journal-title":"Sci Rep"},{"issue":"4","key":"3660_CR35","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1042\/BST20150014","volume":"43","author":"JD Wardyn","year":"2015","unstructured":"Wardyn JD, Ponsford AH, Sanderson CM (2015) Dissecting molecular cross-talk between Nrf2 and NF-kappaB response pathways. Biochem Soc Trans 43(4):621\u2013626","journal-title":"Biochem Soc Trans"},{"key":"3660_CR36","doi-asserted-by":"publisher","first-page":"9372182","DOI":"10.1155\/2019\/9372182","volume":"2019","author":"N Robledinos-Anton","year":"2019","unstructured":"Robledinos-Anton N, Fernandez-Gines R, Manda G, Cuadrado A (2019) Activators and inhibitors of NRF2: a review of their potential for clinical development. Oxid Med Cell Longev 2019:9372182","journal-title":"Oxid Med Cell Longev"},{"issue":"11","key":"3660_CR37","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.bcp.2008.07.017","volume":"76","author":"W Li","year":"2008","unstructured":"Li W, Khor TO, Xu C, Shen G, Jeong WS, Yu S, Kong AN (2008) Activation of Nrf2-antioxidant signaling attenuates NFkappaB-inflammatory response and elicits apoptosis. Biochem Pharmacol 76(11):1485\u20131489","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"3660_CR38","doi-asserted-by":"publisher","first-page":"3553","DOI":"10.4049\/jimmunol.172.6.3553","volume":"172","author":"MP Soares","year":"2004","unstructured":"Soares MP, Seldon MP, Gregoire IP, Vassilevskaia T, Berberat PO, Yu J, Tsui TY, Bach FH (2004) Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation. J Immunol 172(6):3553\u20133563","journal-title":"J Immunol"},{"issue":"1","key":"3660_CR39","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s10571-020-00839-w","volume":"41","author":"T Meng","year":"2021","unstructured":"Meng T, Fu S, He D, Hu G, Gao X, Zhang Y, Huang B, Du J et al (2021) Evodiamine inhibits lipopolysaccharide (LPS)-induced inflammation in BV-2 cells via regulating AKT\/Nrf2-HO-1\/NF-kappaB signaling axis. Cell Mol Neurobiol 41(1):115\u2013127","journal-title":"Cell Mol Neurobiol"},{"issue":"1","key":"3660_CR40","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.redox.2013.07.005","volume":"1","author":"V Ganesh Yerra","year":"2013","unstructured":"Ganesh Yerra V, Negi G, Sharma SS, Kumar A (2013) Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-kappaB pathways in diabetic neuropathy. Redox Biol 1(1):394\u2013397","journal-title":"Redox Biol"},{"key":"3660_CR41","doi-asserted-by":"publisher","first-page":"3242","DOI":"10.1038\/srep03242","volume":"3","author":"YJ Hwang","year":"2013","unstructured":"Hwang YJ, Lee EW, Song J, Kim HR, Jun YC, Hwang KA (2013) MafK positively regulates NF-kappaB activity by enhancing CBP-mediated p65 acetylation. Sci Rep 3:3242","journal-title":"Sci Rep"},{"key":"3660_CR42","doi-asserted-by":"crossref","unstructured":"Yang CC, Lin CC, Jou MJ, Hsiao LD, Yang CM (2019) RTA 408 inhibits interleukin-1beta-induced MMP-9 expression via suppressing protein kinase-dependent NF-kappaB and AP-1 activation in rat brain astrocytes. Int J Mol Sci 20(11): 2826","DOI":"10.3390\/ijms20112826"},{"issue":"5","key":"3660_CR43","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/brain\/awy071","volume":"141","author":"T Shekh-Ahmad","year":"2018","unstructured":"Shekh-Ahmad T, Eckel R, Dayalan Naidu S, Higgins M, Yamamoto M, Dinkova-Kostova AT, Kovac S, Abramov AY et al (2018) KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy. Brain 141(5):1390\u20131403","journal-title":"Brain"},{"issue":"1","key":"3660_CR44","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.bbrc.2007.03.081","volume":"357","author":"K Koyama","year":"2007","unstructured":"Koyama K, Ozawa T, Hatsushika K, Ando T, Takano S, Wako M, Suenaga F, Ohnuma Y et al (2007) A possible role for TSLP in inflammatory arthritis. Biochem Biophys Res Commun 357(1):99\u2013104","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"3660_CR45","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1016\/j.jaci.2014.04.022","volume":"134","author":"E Volpe","year":"2014","unstructured":"Volpe E, Pattarini L, Martinez-Cingolani C, Meller S, Donnadieu MH, Bogiatzi SI, Fernandez MI, Touzot M et al (2014) Thymic stromal lymphopoietin links keratinocytes and dendritic cell-derived IL-23 in patients with psoriasis. J Allergy Clin Immunol 134(2):373\u2013381","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"3660_CR46","doi-asserted-by":"publisher","first-page":"1213","DOI":"10.1084\/jem.20051135","volume":"202","author":"T Ito","year":"2005","unstructured":"Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N, Qin FX, Yao Z et al (2005) TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med 202(9):1213\u20131223","journal-title":"J Exp Med"},{"issue":"5","key":"3660_CR47","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1038\/mi.2012.130","volume":"6","author":"Z Su","year":"2013","unstructured":"Su Z, Lin J, Lu F, Zhang X, Zhang L, Gandhi NB, de Paiva CS, Pflugfelder SC et al (2013) Potential autocrine regulation of interleukin-33\/ST2 signaling of dendritic cells in allergic inflammation. Mucosal Immunol 6(5):921\u2013930","journal-title":"Mucosal Immunol"},{"issue":"4","key":"3660_CR48","first-page":"325","volume":"1","author":"S Esnault","year":"2008","unstructured":"Esnault S, Rosenthal LA, Wang DS, Malter JS (2008) Thymic stromal lymphopoietin (TSLP) as a bridge between infection and atopy. Int J Clin Exp Pathol 1(4):325\u2013330","journal-title":"Int J Clin Exp Pathol"},{"issue":"13","key":"3660_CR49","doi-asserted-by":"publisher","first-page":"7105","DOI":"10.3390\/ijms22137105","volume":"22","author":"CH Wu","year":"2021","unstructured":"Wu CH, Lu CC, Huang CL, Wu MK, Lu YY (2021) Increased expression of thymic stromal lymphopoietin in chronic constriction injury of rat nerve. Int J Mol Sci 22(13):7105","journal-title":"Int J Mol Sci"},{"issue":"12","key":"3660_CR50","doi-asserted-by":"publisher","first-page":"3805","DOI":"10.1007\/s11064-022-03763-1","volume":"47","author":"YY Lu","year":"2022","unstructured":"Lu YY, Lu CC, Huang CL, Tsai HP, Wang WT, Zhang ZH, Wu CH (2022) Linalyl acetate ameliorates mechanical hyperalgesia through suppressing inflammation by TSLP\/IL-33 signaling. Neurochem Res 47(12):3805\u20133816","journal-title":"Neurochem Res"},{"issue":"6","key":"3660_CR51","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","volume":"1","author":"T Lawrence","year":"2009","unstructured":"Lawrence T (2009) The nuclear factor NF-kappaB pathway in inflammation. Cold Spring Harb Perspect Biol 1(6):a001651","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"3660_CR52","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/j.0105-2896.2006.00375.x","volume":"210","author":"A Hoffmann","year":"2006","unstructured":"Hoffmann A, Baltimore D (2006) Circuitry of nuclear factor kappaB signaling. Immunol Rev 210:171\u2013186","journal-title":"Immunol Rev"},{"issue":"8","key":"3660_CR53","doi-asserted-by":"publisher","first-page":"6006","DOI":"10.1007\/s12035-016-0111-0","volume":"54","author":"R Zhang","year":"2017","unstructured":"Zhang R, Xu M, Wang Y, Xie F, Zhang G, Qin X (2017) Nrf2-a promising therapeutic target for defensing against oxidative stress in stroke. Mol Neurobiol 54(8):6006\u20136017","journal-title":"Mol Neurobiol"},{"issue":"4","key":"3660_CR54","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.bbrc.2006.10.102","volume":"351","author":"RK Thimmulappa","year":"2006","unstructured":"Thimmulappa RK, Scollick C, Traore K, Yates M, Trush MA, Liby KT, Sporn MB, Yamamoto M et al (2006) Nrf2-dependent protection from LPS induced inflammatory response and mortality by CDDO-Imidazolide. Biochem Biophys Res Commun 351(4):883\u2013889","journal-title":"Biochem Biophys Res Commun"},{"key":"3660_CR55","doi-asserted-by":"crossref","unstructured":"Lu CC, Lu YY, Tsai HP, Wu CH (2022) The contribution of TSLP activation to hyperalgesia in dorsal root ganglia neurons of a rat. Int J Mol Sci 23(4):2012","DOI":"10.3390\/ijms23042012"},{"issue":"1","key":"3660_CR56","first-page":"119","volume":"182","author":"D Redhu","year":"2020","unstructured":"Redhu D, Franke K, Kumari V, Francuzik W, Babina M, Worm M (2020) Thymic stromal lymphopoietin production induced by skin irritation results from concomitant activation of protease-activated receptor 2 and interleukin 1 pathways. Br J Dermatol 182(1):119\u2013129","journal-title":"Br J Dermatol"},{"key":"3660_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","volume":"32","author":"M Costigan","year":"2009","unstructured":"Costigan M, Scholz J, Woolf CJ (2009) Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 32:1\u201332","journal-title":"Annu Rev Neurosci"},{"issue":"1\u20132","key":"3660_CR58","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.pain.2004.12.022","volume":"114","author":"ZY Zhuang","year":"2005","unstructured":"Zhuang ZY, Gerner P, Woolf CJ, Ji RR (2005) ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114(1\u20132):149\u2013159","journal-title":"Pain"},{"issue":"5","key":"3660_CR59","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1523\/JNEUROSCI.1650-20.2020","volume":"41","author":"PM Grace","year":"2021","unstructured":"Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR (2021) The neuroimmunology of chronic pain: from rodents to humans. J Neurosci 41(5):855\u2013865","journal-title":"J Neurosci"},{"issue":"3","key":"3660_CR60","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.pain.2010.01.001","volume":"148","author":"ES Fu","year":"2010","unstructured":"Fu ES, Zhang YP, Sagen J, Candiotti KA, Morton PD, Liebl DJ, Bethea JR, Brambilla R (2010) Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury. Pain 148(3):509\u2013518","journal-title":"Pain"},{"issue":"5","key":"3660_CR61","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.pharep.2014.05.001","volume":"66","author":"K Popiolek-Barczyk","year":"2014","unstructured":"Popiolek-Barczyk K, Makuch W, Rojewska E, Pilat D, Mika J (2014) Inhibition of intracellular signaling pathways NF-kappaB and MEK1\/2 attenuates neuropathic pain development and enhances morphine analgesia. Pharmacol Rep 66(5):845\u2013851","journal-title":"Pharmacol Rep"},{"issue":"3","key":"3660_CR62","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1073\/pnas.0607305104","volume":"104","author":"HC Lee","year":"2007","unstructured":"Lee HC, Ziegler SF (2007) Inducible expression of the proallergic cytokine thymic stromal lymphopoietin in airway epithelial cells is controlled by NFkappaB. Proc Natl Acad Sci U S A 104(3):914\u2013919","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3660_CR63","doi-asserted-by":"publisher","first-page":"L479","DOI":"10.1152\/ajplung.00301.2009","volume":"300","author":"NS Redhu","year":"2011","unstructured":"Redhu NS, Saleh A, Halayko AJ, Ali AS, Gounni AS (2011) Essential role of NF-kappaB and AP-1 transcription factors in TNF-alpha-induced TSLP expression in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 300(3):L479-485","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"3660_CR64","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/B978-0-12-404717-4.00004-4","volume":"66","author":"SF Ziegler","year":"2013","unstructured":"Ziegler SF, Roan F, Bell BD, Stoklasek TA, Kitajima M, Han H (2013) The biology of thymic stromal lymphopoietin (TSLP). Adv Pharmacol 66:129\u2013155","journal-title":"Adv Pharmacol"},{"issue":"4","key":"3660_CR65","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1002\/eji.201142340","volume":"43","author":"A Cultrone","year":"2013","unstructured":"Cultrone A, de Wouters T, Lakhdari O, Kelly D, Mulder I, Logan E, Lapaque N, Dore J et al (2013) The NF-kappaB binding site located in the proximal region of the TSLP promoter is critical for TSLP modulation in human intestinal epithelial cells. Eur J Immunol 43(4):1053\u20131062","journal-title":"Eur J Immunol"},{"issue":"6","key":"3660_CR66","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/resp.13711","volume":"25","author":"G An","year":"2020","unstructured":"An G, Wang W, Zhang X, Huang Q, Li Q, Chen S, Du X, Corrigan CJ et al (2020) Combined blockade of IL-25, IL-33 and TSLP mediates amplified inhibition of airway inflammation and remodelling in a murine model of asthma. Respirology 25(6):603\u2013612","journal-title":"Respirology"},{"issue":"4","key":"3660_CR67","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1038\/s41573-018-0008-x","volume":"18","author":"A Cuadrado","year":"2019","unstructured":"Cuadrado A, Rojo AI, Wells G, Hayes JD, Cousin SP, Rumsey WL, Attucks OC, Franklin S et al (2019) Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases. Nat Rev Drug Discov 18(4):295\u2013317","journal-title":"Nat Rev Drug Discov"},{"issue":"8","key":"3660_CR68","doi-asserted-by":"publisher","first-page":"1807","DOI":"10.2337\/db08-0178","volume":"58","author":"LG Grunnet","year":"2009","unstructured":"Grunnet LG, Aikin R, Tonnesen MF, Paraskevas S, Blaabjerg L, Storling J, Rosenberg L, Billestrup N et al (2009) Proinflammatory cytokines activate the intrinsic apoptotic pathway in beta-cells. Diabetes 58(8):1807\u20131815","journal-title":"Diabetes"},{"issue":"8","key":"3660_CR69","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00262-011-1008-4","volume":"60","author":"TJ Sayers","year":"2011","unstructured":"Sayers TJ (2011) Targeting the extrinsic apoptosis signaling pathway for cancer therapy. Cancer Immunol Immunother 60(8):1173\u20131180","journal-title":"Cancer Immunol Immunother"},{"issue":"12","key":"3660_CR70","doi-asserted-by":"publisher","first-page":"1978","DOI":"10.1007\/s00586-009-1064-z","volume":"18","author":"M Sekiguchi","year":"2009","unstructured":"Sekiguchi M, Sekiguchi Y, Konno S, Kobayashi H, Homma Y, Kikuchi S (2009) Comparison of neuropathic pain and neuronal apoptosis following nerve root or spinal nerve compression. Eur Spine J 18(12):1978\u20131985","journal-title":"Eur Spine J"},{"issue":"2","key":"3660_CR71","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.phrs.2006.11.009","volume":"55","author":"D Siniscalco","year":"2007","unstructured":"Siniscalco D, Fuccio C, Giordano C, Ferraraccio F, Palazzo E, Luongo L, Rossi F, Roth KA et al (2007) Role of reactive oxygen species and spinal cord apoptotic genes in the development of neuropathic pain. Pharmacol Res 55(2):158\u2013166","journal-title":"Pharmacol Res"},{"issue":"2","key":"3660_CR72","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1002\/glia.20910","volume":"58","author":"V Schaeffer","year":"2010","unstructured":"Schaeffer V, Meyer L, Patte-Mensah C, Eckert A, Mensah-Nyagan AG (2010) Sciatic nerve injury induces apoptosis of dorsal root ganglion satellite glial cells and selectively modifies neurosteroidogenesis in sensory neurons. Glia 58(2):169\u2013180","journal-title":"Glia"},{"key":"3660_CR73","doi-asserted-by":"publisher","first-page":"8854461","DOI":"10.1155\/2021\/8854461","volume":"2021","author":"CH Wu","year":"2021","unstructured":"Wu CH, Wu MK, Lu CC, Tsai HP, Lu YY, Lin CL (2021) Impact of hepatoma-derived growth factor blockade on resiniferatoxin-induced neuropathy. Neural Plast 2021:8854461","journal-title":"Neural Plast"},{"issue":"1","key":"3660_CR74","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1515\/sjpain-2019-0138","volume":"20","author":"M Malcangio","year":"2019","unstructured":"Malcangio M (2019) Role of the immune system in neuropathic pain. Scand J Pain 20(1):33\u201337","journal-title":"Scand J Pain"},{"key":"3660_CR75","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.brainres.2011.06.022","volume":"1405","author":"CF Kim","year":"2011","unstructured":"Kim CF, Moalem-Taylor G (2011) Detailed characterization of neuro-immune responses following neuropathic injury in mice. Brain Res 1405:95\u2013108","journal-title":"Brain Res"},{"issue":"6","key":"3660_CR76","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1016\/j.celrep.2017.04.047","volume":"19","author":"Y Shinozaki","year":"2017","unstructured":"Shinozaki Y, Shibata K, Yoshida K, Shigetomi E, Gachet C, Ikenaka K, Tanaka KF, Koizumi S (2017) Transformation of astrocytes to a neuroprotective phenotype by microglia via P2Y1 receptor downregulation. Cell Rep 19(6):1151\u20131164","journal-title":"Cell Rep"},{"issue":"8","key":"3660_CR77","doi-asserted-by":"publisher","first-page":"e23510","DOI":"10.1371\/journal.pone.0023510","volume":"6","author":"K Shibata","year":"2011","unstructured":"Shibata K, Sugawara T, Fujishita K, Shinozaki Y, Matsukawa T, Suzuki T, Koizumi S (2011) The astrocyte-targeted therapy by Bushi for the neuropathic pain in mice. PLoS One 6(8):e23510","journal-title":"PLoS One"},{"key":"3660_CR78","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.sjpain.2015.10.002","volume":"10","author":"L Block","year":"2016","unstructured":"Block L (2016) Glial dysfunction and persistent neuropathic postsurgical pain. Scand J Pain 10:74\u201381","journal-title":"Scand J Pain"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03660-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03660-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03660-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T09:26:19Z","timestamp":1708939579000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03660-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":78,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["3660"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03660-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"15 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Institutional Animal Care and Use Committee (IACUC) of Kaohsiung Medical University approved the protocols of all experiments involving animals (approval number: 108279).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}