{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:44:08Z","timestamp":1783025048023,"version":"3.54.6"},"reference-count":258,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:00:00Z","timestamp":1699833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s12035-023-03684-2","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:02:02Z","timestamp":1699840922000},"page":"2996-3018","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurodegenerative Etiology of Aromatic L-Amino Acid Decarboxylase Deficiency: a Novel Concept for Expanding Treatment Strategies"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2624-536X","authenticated-orcid":false,"given":"Zohi","family":"Sternberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,13]]},"reference":[{"issue":"3","key":"3684_CR1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1007\/BF01799380","volume":"13","author":"K Hyland","year":"1990","unstructured":"Hyland K, Clayton PT (1990) Aromatic amino acid decarboxylase deficiency in twins. J Inherit Metab Dis 13(3):301\u2013304","journal-title":"J Inherit Metab Dis"},{"issue":"8","key":"3684_CR2","doi-asserted-by":"publisher","first-page":"e71741","DOI":"10.1371\/journal.pone.0071741","volume":"8","author":"DF Shih","year":"2013","unstructured":"Shih DF, Hsiao CD, Min MY, Lai WS, Yang CW, Lee WT, Lee SJ (2013) Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions. PLoS ONE 8(8):e71741","journal-title":"PLoS ONE"},{"issue":"12","key":"3684_CR3","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nrn1256","volume":"4","author":"P Gaspar","year":"2003","unstructured":"Gaspar P, Cases O, Maroteaux L (2003) The developmental role of serotonin: news from mouse molecular genetics. Nat Rev Neurosci 4(12):1002\u20131012","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"3684_CR4","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1212\/WNL.0b013e3181e620ae","volume":"75","author":"L Brun","year":"2010","unstructured":"Brun L, Ngu LH, Keng WT, Ch\u2019ng GS, Choy YS, Hwu WL, Lee WT, Willemsen MA et al (2010) Clinical and biochemical features of aromatic L-amino acid decarboxylase deficiency. Neurology 75(1):64\u201371","journal-title":"Neurology"},{"issue":"5","key":"3684_CR5","doi-asserted-by":"publisher","first-page":"1121","DOI":"10.1002\/jimd.12247","volume":"43","author":"TS Pearson","year":"2020","unstructured":"Pearson TS, Gilbert L, Opladen T, Garcia-Cazorla A, Mastrangelo M, Leuzzi V, Tay SKH, Sykut-Cegielska J et al (2020) AADC deficiency from infancy to adulthood: symptoms and developmental outcome in an international cohort of 63 patients. J Inherit Metab Dis 43(5):1121\u20131130","journal-title":"J Inherit Metab Dis"},{"issue":"5","key":"3684_CR6","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1002\/jmd2.12387","volume":"64","author":"W-L Hwu","year":"2023","unstructured":"Hwu W-L (2023) Aromatic L-amino acid decarboxylase deficiency in Taiwan. JIMD Rep 64(5):387\u2013392","journal-title":"JIMD Rep"},{"key":"3684_CR7","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.parkreldis.2019.07.018","volume":"66","author":"FL Hitti","year":"2019","unstructured":"Hitti FL, Yang AI, Gonzalez-Alegre P, Baltuch GH (2019) Human gene therapy approaches for the treatment of Parkinson\u2019s disease: an overview of current and completed clinical trials. Parkinsonism Relat Disord 66:16\u201324","journal-title":"Parkinsonism Relat Disord"},{"issue":"1","key":"3684_CR8","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13023-016-0522-z","volume":"12","author":"T Wassenberg","year":"2017","unstructured":"Wassenberg T, Molero-Luis M, Jeltsch K, Hoffmann GF, Assmann B, Blau N, Garcia-Cazorla A, Artuch R et al (2017) Consensus guideline for the diagnosis and treatment of aromatic l-amino acid decarboxylase (AADC) deficiency. Orphanet J Rare Dis 12(1):12","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"3684_CR9","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/mds.22385","volume":"24","author":"F Andersohn","year":"2009","unstructured":"Andersohn F, Garbe E (2009) Cardiac and noncardiac fibrotic reactions caused by ergot-and nonergot-derived dopamine agonists. Mov Disord 24(1):129\u2013133","journal-title":"Mov Disord"},{"issue":"10","key":"3684_CR10","doi-asserted-by":"publisher","first-page":"1349","DOI":"10.1016\/0026-0495(95)90041-1","volume":"44","author":"AH Cincotta","year":"1995","unstructured":"Cincotta AH, Meier AH (1995) Bromocriptine inhibits in vivo free fatty acid oxidation and hepatic glucose output in seasonally obese hamsters (Mesocricetus auratus). Metabolism 44(10):1349\u20131355","journal-title":"Metabolism"},{"issue":"1","key":"3684_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000054344","volume":"68","author":"S Luo","year":"1998","unstructured":"Luo S, Meier AH, Cincotta AH (1998) Bromocriptine reduces obesity, glucose intolerance and extracellular monoamine metabolite levels in the ventromedial hypothalamus of Syrian hamsters. Neuroendocrinology 68(1):1\u201310","journal-title":"Neuroendocrinology"},{"issue":"1","key":"3684_CR12","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ymgme.2019.03.009","volume":"127","author":"N Himmelreich","year":"2019","unstructured":"Himmelreich N, Montioli R, Bertoldi M, Carducci C, Leuzzi V, Gemperle C, Berner T, Hyland K et al (2019) Aromatic amino acid decarboxylase deficiency: molecular and metabolic basis and therapeutic outlook. Mol Genet Metab 127(1):12\u201322","journal-title":"Mol Genet Metab"},{"issue":"3","key":"3684_CR13","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s10545-009-1076-1","volume":"32","author":"C Manegold","year":"2009","unstructured":"Manegold C, Hoffmann GF, Degen I, Ikonomidou H, Knust A, Laass MW, Pritsch M, Wilichowski E et al (2009) Aromatic L-amino acid decarboxylase deficiency: clinical features, drug therapy and follow-up. J Inherit Metab Dis 32(3):371\u2013380","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"3684_CR14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1006\/exnr.2000.7408","volume":"164","author":"KS Bankiewicz","year":"2000","unstructured":"Bankiewicz KS, Eberling JL, Kohutnicka M, Jagust W, Pivirotto P, Bringas J, Cunningham J, Budinger TF et al (2000) Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 164(1):2\u201314","journal-title":"Exp Neurol"},{"issue":"20","key":"3684_CR15","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1212\/WNL.0b013e3181c29356","volume":"73","author":"CW Christine","year":"2009","unstructured":"Christine CW, Starr PA, Larson PS, Eberling JL, Jagust WJ, Hawkins RA, VanBrocklin HF, Wright JF et al (2009) Safety and tolerability of putaminal AADC gene therapy for Parkinson disease. Neurology 73(20):1662\u20131669","journal-title":"Neurology"},{"issue":"9","key":"3684_CR16","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1038\/mt.2010.135","volume":"18","author":"S Muramatsu","year":"2010","unstructured":"Muramatsu S, Fujimoto K, Kato S, Mizukami H, Asari S, Ikeguchi K, Kawakami T, Urabe M et al (2010) A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson\u2019s disease. Mol Ther 18(9):1731\u20131735","journal-title":"Mol Ther"},{"issue":"134","key":"3684_CR17","doi-asserted-by":"publisher","first-page":"134ra61","DOI":"10.1126\/scitranslmed.3003640","volume":"4","author":"WL Hwu","year":"2012","unstructured":"Hwu WL, Muramatsu S, Tseng SH, Tzen KY, Lee NC, Chien YH, Snyder RO, Byrne BJ et al (2012) Gene therapy for aromatic L-amino acid decarboxylase deficiency. Sci Transl Med 4(134):134ra61","journal-title":"Sci Transl Med"},{"issue":"4","key":"3684_CR18","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S2352-4642(17)30125-6","volume":"1","author":"YH Chien","year":"2017","unstructured":"Chien YH, Lee NC, Tseng SH, Tai CH, Muramatsu SI, Byrne BJ, Hwu WL (2017) Efficacy and safety of AAV2 gene therapy in children with aromatic L-amino acid decarboxylase deficiency: an open-label, phase 1\/2 trial. Lancet Child Adolesc Health 1(4):265\u2013273","journal-title":"Lancet Child Adolesc Health"},{"issue":"2","key":"3684_CR19","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1016\/j.ymthe.2021.11.005","volume":"30","author":"CH Tai","year":"2022","unstructured":"Tai CH, Lee NC, Chien YH, Byrne BJ, Muramatsu SI, Tseng SH, Hwu WL (2022) Long-term efficacy and safety of eladocagene exuparvovec in patients with AADC deficiency. Mol Ther 30(2):509\u2013518","journal-title":"Mol Ther"},{"issue":"1","key":"3684_CR20","doi-asserted-by":"publisher","first-page":"4251","DOI":"10.1038\/s41467-021-24524-8","volume":"12","author":"TS Pearson","year":"2021","unstructured":"Pearson TS, Gupta N, San Sebastian W, Imamura-Ching J, Viehoever A, Grijalvo-Perez A, Fay AJ, Seth N et al (2021) Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons. Nat Commun 12(1):4251","journal-title":"Nat Commun"},{"issue":"3","key":"3684_CR21","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s10545-009-1106-z","volume":"32","author":"WT Lee","year":"2009","unstructured":"Lee WT, Weng WC, Peng SF, Tzen KY (2009) Neuroimaging findings in children with paediatric neurotransmitter diseases. J Inherit Metab Dis 32(3):361\u2013370","journal-title":"J Inherit Metab Dis"},{"issue":"13","key":"3684_CR22","first-page":"1427","volume":"82","author":"SJ Keam","year":"2022","unstructured":"Keam SJ (2022) Eladocagene exuparvovec: first approval. Drugs 82(13):1427\u20131432","journal-title":"Drugs"},{"issue":"1","key":"3684_CR23","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1006\/exnr.2001.7726","volume":"171","author":"WQ Zhao","year":"2001","unstructured":"Zhao WQ, Latinwo L, Liu XX, Lee ES, Lamango N, Charlton CG (2001) L-dopa upregulates the expression and activities of methionine adenosyl transferase and catechol-O-methyltransferase. Exp Neurol 171(1):127\u2013138","journal-title":"Exp Neurol"},{"key":"3684_CR24","doi-asserted-by":"crossref","first-page":"100762","DOI":"10.1016\/j.ymgmr.2021.100762","volume":"27","author":"T Wassenberg","year":"2021","unstructured":"Wassenberg T, Geurtz BPH, Monnens L, Wevers RA, Willemsen MA, Verbeek MM (2021) Blood, urine and cerebrospinal fluid analysis in TH and AADC deficiency and the effect of treatment. Mol Genet Metab Rep 27:100762","journal-title":"Mol Genet Metab Rep"},{"issue":"1","key":"3684_CR25","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1097\/00002826-199702000-00007","volume":"20","author":"JW Miller","year":"1997","unstructured":"Miller JW, Shukitt-Hale B, Villalobos-Molina R, Nadeau MR, Selhub J, Joseph JA (1997) Effect of L-dopa and the catechol-O-methyltransferase inhibitor Ro 41\u20130960 on sulfur amino acid metabolites in rats. Clin Neuropharmacol 20(1):55\u201366","journal-title":"Clin Neuropharmacol"},{"issue":"23","key":"3684_CR26","doi-asserted-by":"publisher","first-page":"2277","DOI":"10.1016\/S0024-3205(00)00557-9","volume":"66","author":"XX Liu","year":"2000","unstructured":"Liu XX, Wilson K, Charlton CG (2000) Effects of L-dopa treatment on methylation in mouse brain: implications for the side effects of L-dopa. Life Sci 66(23):2277\u20132288","journal-title":"Life Sci"},{"issue":"2","key":"3684_CR27","doi-asserted-by":"publisher","first-page":"773","DOI":"10.3233\/JAD-200234","volume":"77","author":"T Hasegawa","year":"2020","unstructured":"Hasegawa T, Kosoku Y, Sano Y, Yoshida H, Kudoh C, Tabira T (2020) Homocysteic acid in blood can detect mild cognitive impairment: a preliminary study. J Alzheimers Dis 77(2):773\u2013780","journal-title":"J Alzheimers Dis"},{"issue":"2","key":"3684_CR28","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1073\/pnas.0909737107","volume":"107","author":"M Sibrian-Vazquez","year":"2010","unstructured":"Sibrian-Vazquez M, Escobedo JO, Lim S, Samoei GK, Strongin RM (2010) Homocystamides promote free-radical and oxidative damage to proteins. Proc Natl Acad Sci U S A 107(2):551\u2013554","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"3684_CR29","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/biof.1354","volume":"43","author":"M Kumar","year":"2017","unstructured":"Kumar M, Modi M, Sandhir R (2017) Hydrogen sulfide attenuates homocysteine-induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels. BioFactors 43(3):434\u2013450","journal-title":"BioFactors"},{"issue":"3","key":"3684_CR30","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1523\/JNEUROSCI.16-03-01066.1996","volume":"16","author":"K Abe","year":"1996","unstructured":"Abe K, Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16(3):1066\u20131071","journal-title":"J Neurosci"},{"issue":"4","key":"3684_CR31","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.bbrc.2013.02.131","volume":"433","author":"K Modis","year":"2013","unstructured":"Modis K, Asimakopoulou A, Coletta C, Papapetropoulos A, Szabo C (2013) Oxidative stress suppresses the cellular bioenergetic effect of the 3-mercaptopyruvate sulfurtransferase\/hydrogen sulfide pathway. Biochem Biophys Res Commun 433(4):401\u2013407","journal-title":"Biochem Biophys Res Commun"},{"issue":"12","key":"3684_CR32","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1021\/bi9018658","volume":"49","author":"EA Sabens","year":"2010","unstructured":"Sabens EA, Distler AM, Mieyal JJ (2010) Levodopa deactivates enzymes that regulate thiol-disulfide homeostasis and promotes neuronal cell death: implications for therapy of Parkinson\u2019s disease. Biochemistry 49(12):2715\u20132724","journal-title":"Biochemistry"},{"key":"3684_CR33","doi-asserted-by":"publisher","first-page":"488","DOI":"10.3389\/fncel.2018.00488","volume":"12","author":"S Bachiller","year":"2018","unstructured":"Bachiller S, Jimenez-Ferrer I, Paulus A, Yang Y, Swanberg M, Deierborg T, Boza-Serrano A (2018) Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response. Front Cell Neurosci 12:488","journal-title":"Front Cell Neurosci"},{"key":"3684_CR34","doi-asserted-by":"publisher","first-page":"742065","DOI":"10.3389\/fnins.2021.742065","volume":"15","author":"L Muzio","year":"2021","unstructured":"Muzio L, Viotti A, Martino G (2021) Microglia in neuroinflammation and neurodegeneration: from understanding to therapy. Front Neurosci 15:742065","journal-title":"Front Neurosci"},{"issue":"6","key":"3684_CR35","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","volume":"46","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Barres BA (2017) Reactive astrocytes: production, function, and therapeutic potential. Immunity 46(6):957\u2013967","journal-title":"Immunity"},{"issue":"7638","key":"3684_CR36","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","volume":"541","author":"SA Liddelow","year":"2017","unstructured":"Liddelow SA, Guttenplan KA, Clarke LE, Bennett FC, Bohlen CJ, Schirmer L, Bennett ML, Munch AE et al (2017) Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541(7638):481\u2013487","journal-title":"Nature"},{"issue":"21","key":"3684_CR37","first-page":"2003","volume":"8","author":"C Guo","year":"2013","unstructured":"Guo C, Sun L, Chen X, Zhang D (2013) Oxidative stress, mitochondrial damage and neurodegenerative diseases. Neural Regen Res 8(21):2003\u20132014","journal-title":"Neural Regen Res"},{"issue":"2","key":"3684_CR38","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1007\/s12640-009-9129-7","volume":"18","author":"Y Chen","year":"2010","unstructured":"Chen Y, Stankovic R, Cullen KM, Meininger V, Garner B, Coggan S, Grant R, Brew BJ et al (2010) The kynurenine pathway and inflammation in amyotrophic lateral sclerosis. Neurotox Res 18(2):132\u2013142","journal-title":"Neurotox Res"},{"issue":"13","key":"3684_CR39","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1097\/WNR.0000000000001817","volume":"33","author":"Y Zhang","year":"2022","unstructured":"Zhang Y, Wang L, Ren W (2022) Blast-related traumatic brain injury is mediated by the kynurenine pathway. NeuroReport 33(13):569\u2013576","journal-title":"NeuroReport"},{"issue":"5","key":"3684_CR40","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1523\/JNEUROSCI.22-05-01967.2002","volume":"22","author":"P Popoli","year":"2002","unstructured":"Popoli P, Pintor A, Domenici MR, Frank C, Tebano MT, Pezzola A, Scarchilli L, Quarta D et al (2002) Blockade of striatal adenosine A2A receptor reduces, through a presynaptic mechanism, quinolinic acid-induced excitotoxicity: possible relevance to neuroprotective interventions in neurodegenerative diseases of the striatum. J Neurosci 22(5):1967\u20131975","journal-title":"J Neurosci"},{"issue":"2","key":"3684_CR41","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/S0006-8993(00)02339-8","volume":"868","author":"A Fisher","year":"2000","unstructured":"Fisher A, Starr MS (2000) Opposite effects of glutamate antagonists and antiparkinsonian drugs on the activities of DOPA decarboxylase and 5-HTP decarboxylase in the rat brain. Brain Res 868(2):268\u2013274","journal-title":"Brain Res"},{"key":"3684_CR42","unstructured":"Allen GFG\u00a0(2010) The neurochemical consequences of aromatic L-amino acid decarboxylase deficiency. UCL Institute of Neurology, London"},{"issue":"4","key":"3684_CR43","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/cpt1971124678","volume":"12","author":"I Kuruma","year":"1971","unstructured":"Kuruma I, Bartholini G, Tissot R, Pletscher A (1971) The metabolism of L-3-O-methyldopa, a precursor of dopa in man. Clin Pharmacol Ther 12(4):678\u2013682","journal-title":"Clin Pharmacol Ther"},{"issue":"2","key":"3684_CR44","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1097\/00002826-198604000-00008","volume":"9","author":"MH Marion","year":"1986","unstructured":"Marion MH, Stocchi F, Quinn NP, Jenner P, Marsden CD (1986) Repeated levodopa infusions in fluctuating Parkinson\u2019s disease: clinical and pharmacokinetic data. Clin Neuropharmacol 9(2):165\u2013181","journal-title":"Clin Neuropharmacol"},{"issue":"3","key":"3684_CR45","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s11064-007-9442-6","volume":"33","author":"ES Lee","year":"2008","unstructured":"Lee ES, Chen H, King J, Charlton C (2008) The role of 3-O-methyldopa in the side effects of L-dopa. Neurochem Res 33(3):401\u2013411","journal-title":"Neurochem Res"},{"issue":"9","key":"3684_CR46","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.3390\/pharmaceutics13091395","volume":"13","author":"U Adamiak-Giera","year":"2021","unstructured":"Adamiak-Giera U, Jawien W, Pierzchlinska A, Bialecka M, Kobierski JD, Janus T, Gawronska-Szklarz B (2021) Pharmacokinetics of levodopa and 3-O-methyldopa in parkinsonian patients treated with levodopa and ropinirole and in patients with motor complications. Pharmaceutics 13(9):1395","journal-title":"Pharmaceutics"},{"issue":"6","key":"3684_CR47","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1111\/j.1600-0404.1977.tb01456.x","volume":"56","author":"C Feuerstein","year":"1977","unstructured":"Feuerstein C, Serre F, Gavend M, Pellat J, Perret J, Tanche M (1977) Plasma O-methyldopa in levodopa-induced dyskinesias. A bioclinical investigation. Acta Neurol Scand 56(6):508\u2013524","journal-title":"Acta Neurol Scand"},{"key":"3684_CR48","first-page":"481","volume":"45","author":"MA Mena","year":"1987","unstructured":"Mena MA, Muradas V, Bazan E, Reiriz J, de Yebenes JG (1987) Pharmacokinetics of L-dopa in patients with Parkinson\u2019s disease. Adv Neurol 45:481\u2013486","journal-title":"Adv Neurol"},{"issue":"4","key":"3684_CR49","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1001\/archneur.1977.00500160042007","volume":"34","author":"L Rivera-Calimlim","year":"1977","unstructured":"Rivera-Calimlim L, Tandon D, Anderson F, Joynt R (1977) The clinical picture and plasma levodopa metabolite profile of parkinsonian nonresponders. Treatment with levodopa and decarboxylase inhibitor. Arch Neurol 34(4):228\u2013232","journal-title":"Arch Neurol"},{"issue":"1","key":"3684_CR50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/0304-3940(91)90422-P","volume":"132","author":"H Tohgi","year":"1991","unstructured":"Tohgi H, Abe T, Kikuchi T, Takahashi S, Nozaki Y (1991) The significance of 3-O-methyldopa concentrations in the cerebrospinal fluid in the pathogenesis of wearing-off phenomenon in Parkinson\u2019s disease. Neurosci Lett 132(1):19\u201322","journal-title":"Neurosci Lett"},{"key":"3684_CR51","doi-asserted-by":"crossref","first-page":"100744","DOI":"10.1016\/j.ymgmr.2021.100744","volume":"27","author":"F Kubaski","year":"2021","unstructured":"Kubaski F, Herbst ZM, Pereira DAA, Silva C, Chen C, Hwu PWL, van der Linden H, Lourenco CM et al (2021) Evaluation of 3-O-methyldopa as a biomarker for aromatic L-amino acid decarboxylase deficiency in 7 Brazilian cases. Mol Genet Metab Rep 27:100744","journal-title":"Mol Genet Metab Rep"},{"issue":"1","key":"3684_CR52","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.ymgme.2021.03.009","volume":"133","author":"A Burlina","year":"2021","unstructured":"Burlina A, Giuliani A, Polo G, Gueraldi D, Gragnaniello V, Cazzorla C, Opladen T, Hoffmann G et al (2021) Detection of 3-O-methyldopa in dried blood spots for neonatal diagnosis of aromatic L-amino-acid decarboxylase deficiency: the northeastern Italian experience. Mol Genet Metab 133(1):56\u201362","journal-title":"Mol Genet Metab"},{"issue":"7","key":"3684_CR53","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.3390\/nu12072135","volume":"12","author":"AM Czarnecka","year":"2020","unstructured":"Czarnecka AM, Hilgier W, Zielinska M (2020) S-adenosylmethionine deficiency and brain accumulation of S-adenosylhomocysteine in thioacetamide-induced acute liver failure. Nutrients 12(7):2135","journal-title":"Nutrients"},{"issue":"10","key":"3684_CR54","doi-asserted-by":"publisher","first-page":"1852","DOI":"10.1373\/clinchem.2009.125021","volume":"55","author":"R Obeid","year":"2009","unstructured":"Obeid R, Schadt A, Dillmann U, Kostopoulos P, Fassbender K, Herrmann W (2009) Methylation status and neurodegenerative markers in Parkinson disease. Clin Chem 55(10):1852\u20131860","journal-title":"Clin Chem"},{"issue":"3","key":"3684_CR55","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neures.2010.03.008","volume":"67","author":"A Alachkar","year":"2010","unstructured":"Alachkar A, Brotchie JM, Jones OT (2010) Binding of dopamine and 3-methoxytyramine as l-DOPA metabolites to human alpha(2)-adrenergic and dopaminergic receptors. Neurosci Res 67(3):245\u2013249","journal-title":"Neurosci Res"},{"issue":"4","key":"3684_CR56","doi-asserted-by":"publisher","first-page":"261","DOI":"10.2165\/00003088-200241040-00003","volume":"41","author":"D Deleu","year":"2002","unstructured":"Deleu D, Northway MG, Hanssens Y (2002) Clinical pharmacokinetic and pharmacodynamic properties of drugs used in the treatment of Parkinson\u2019s disease. Clin Pharmacokinet 41(4):261\u2013309","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"3684_CR57","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/0024-3205(75)90248-9","volume":"17","author":"LA Wade","year":"1975","unstructured":"Wade LA, Katzman R (1975) 3-O-methyldopa uptake and inhibition of L-dopa at the blood-brain barrier. Life Sci 17(1):131\u2013136","journal-title":"Life Sci"},{"issue":"10","key":"3684_CR58","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1038\/ncpneuro0293","volume":"2","author":"WJ Weiner","year":"2006","unstructured":"Weiner WJ (2006) Levodopa\u2013toxic or neuroprotective? Nat Clin Pract Neurol 2(10):518\u2013519","journal-title":"Nat Clin Pract Neurol"},{"issue":"1","key":"3684_CR59","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/mds.870120105","volume":"12","author":"I Ziv","year":"1997","unstructured":"Ziv I, Zilkha-Falb R, Offen D, Shirvan A, Barzilai A, Melamed E (1997) Levodopa induces apoptosis in cultured neuronal cells\u2013a possible accelerator of nigrostriatal degeneration in Parkinson\u2019s disease? Mov Disord 12(1):17\u201323","journal-title":"Mov Disord"},{"issue":"2","key":"3684_CR60","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1021\/pr0499747","volume":"3","author":"J Pierson","year":"2004","unstructured":"Pierson J, Norris JL, Aerni HR, Svenningsson P, Caprioli RM, Andren PE (2004) Molecular profiling of experimental Parkinson\u2019s disease: direct analysis of peptides and proteins on brain tissue sections by MALDI mass spectrometry. J Proteome Res 3(2):289\u2013295","journal-title":"J Proteome Res"},{"issue":"2","key":"3684_CR61","doi-asserted-by":"publisher","first-page":"e1589","DOI":"10.1371\/journal.pone.0001589","volume":"3","author":"B Scholz","year":"2008","unstructured":"Scholz B, Svensson M, Alm H, Skold K, Falth M, Kultima K, Guigoni C, Doudnikoff E et al (2008) Striatal proteomic analysis suggests that first L-dopa dose equates to chronic exposure. PLoS ONE 3(2):e1589","journal-title":"PLoS ONE"},{"issue":"1","key":"3684_CR62","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0300-483X(02)00193-2","volume":"177","author":"DI Pattison","year":"2002","unstructured":"Pattison DI, Dean RT, Davies MJ (2002) Oxidation of DNA, proteins and lipids by DOPA, protein-bound DOPA, and related catechol(amine)s. Toxicology 177(1):23\u201337","journal-title":"Toxicology"},{"key":"3684_CR63","doi-asserted-by":"publisher","first-page":"110473","DOI":"10.1016\/j.biopha.2020.110473","volume":"130","author":"AM Shehata","year":"2020","unstructured":"Shehata AM, Ahmed-Farid OA, Rizk HA, Saber SM, Lashin FM, Re L (2020) Neurochemical, neurobehavioral and histochemical effects of therapeutic dose of l-dopa on striatal neurons in rats: protective effect of virgin coconut oil. Biomed Pharmacother 130:110473","journal-title":"Biomed Pharmacother"},{"issue":"1","key":"3684_CR64","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.neuron.2014.11.018","volume":"85","author":"H Lian","year":"2015","unstructured":"Lian H, Yang L, Cole A, Sun L, Chiang AC, Fowler SW, Shim DJ, Rodriguez-Rivera J et al (2015) NFkappaB-activated astroglial release of complement C3 compromises neuronal morphology and function associated with Alzheimer\u2019s disease. Neuron 85(1):101\u2013115","journal-title":"Neuron"},{"issue":"1","key":"3684_CR65","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1002\/mds.870070105","volume":"7","author":"MA Mena","year":"1992","unstructured":"Mena MA, Pardo B, Casarejos MJ, Fahn S, Garcia de Yebenes J (1992) Neurotoxicity of levodopa on catecholamine-rich neurons. Mov Disord 7(1):23\u201331","journal-title":"Mov Disord"},{"issue":"3","key":"3684_CR66","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/S0006-2952(96)00731-9","volume":"53","author":"CT Lai","year":"1997","unstructured":"Lai CT, Yu PH (1997) Dopamine- and L-beta-3,4-dihydroxyphenylalanine hydrochloride (L-Dopa)-induced cytotoxicity towards catecholaminergic neuroblastoma SH-SY5Y cells. Effects of oxidative stress and antioxidative factors. Biochem Pharmacol 53(3):363\u2013372","journal-title":"Biochem Pharmacol"},{"issue":"2","key":"3684_CR67","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/S0197-0186(02)00075-X","volume":"42","author":"H Blessing","year":"2003","unstructured":"Blessing H, Bareiss M, Zettlmeisl H, Schwarz J, Storch A (2003) Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity. Neurochem Int 42(2):139\u2013151","journal-title":"Neurochem Int"},{"issue":"2","key":"3684_CR68","doi-asserted-by":"publisher","first-page":"792","DOI":"10.1124\/jpet.102.042267","volume":"304","author":"C Mytilineou","year":"2003","unstructured":"Mytilineou C, Walker RH, JnoBaptiste R, Olanow CW (2003) Levodopa is toxic to dopamine neurons in an in vitro but not an in vivo model of oxidative stress. J Pharmacol Exp Ther 304(2):792\u2013800","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"3684_CR69","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1046\/j.1471-4159.1996.66020501.x","volume":"66","author":"SK Han","year":"1996","unstructured":"Han SK, Mytilineou C, Cohen G (1996) L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. J Neurochem 66(2):501\u2013510","journal-title":"J Neurochem"},{"issue":"2","key":"3684_CR70","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1007\/s12035-014-8835-1","volume":"51","author":"W Jang","year":"2015","unstructured":"Jang W, Park HH, Lee KY, Lee YJ, Kim HT, Koh SH (2015) 1,25-Dyhydroxyvitamin D3 attenuates L-DOPA-induced neurotoxicity in neural stem cells. Mol Neurobiol 51(2):558\u2013570","journal-title":"Mol Neurobiol"},{"issue":"2","key":"3684_CR71","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1046\/j.1471-4159.1995.64020576.x","volume":"64","author":"B Pardo","year":"1995","unstructured":"Pardo B, Mena MA, de Yebenes JG (1995) L-dopa inhibits complex IV of the electron transport chain in catecholamine-rich human neuroblastoma NB69 cells. J Neurochem 64(2):576\u2013582","journal-title":"J Neurochem"},{"issue":"11","key":"3684_CR72","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1089\/dna.2011.1546","volume":"31","author":"M Colamartino","year":"2012","unstructured":"Colamartino M, Padua L, Meneghini C, Leone S, Cornetta T, Testa A, Cozzi R (2012) Protective effects of L-dopa and carbidopa combined treatments on human catecholaminergic cells. DNA Cell Biol 31(11):1572\u20131579","journal-title":"DNA Cell Biol"},{"issue":"4","key":"3684_CR73","doi-asserted-by":"publisher","first-page":"1398","DOI":"10.1046\/j.1471-4159.1997.69041398.x","volume":"69","author":"MA Mena","year":"1997","unstructured":"Mena MA, Davila V, Sulzer D (1997) Neurotrophic effects of L-DOPA in postnatal midbrain dopamine neuron\/cortical astrocyte cocultures. J Neurochem 69(4):1398\u20131408","journal-title":"J Neurochem"},{"issue":"1","key":"3684_CR74","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12868-016-0289-0","volume":"17","author":"M Asanuma","year":"2016","unstructured":"Asanuma M, Miyazaki I (2016) 3-O-methyldopa inhibits astrocyte-mediated dopaminergic neuroprotective effects of L-DOPA. BMC Neurosci 17(1):52","journal-title":"BMC Neurosci"},{"issue":"1","key":"3684_CR75","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1002\/1097-4547(20001001)62:1<112::AID-JNR12>3.0.CO;2-6","volume":"62","author":"K Koshimura","year":"2000","unstructured":"Koshimura K, Tanaka J, Murakami Y, Kato Y (2000) Effects of dopamine and L-DOPA on survival of PC12 cells. J Neurosci Res 62(1):112\u2013119","journal-title":"J Neurosci Res"},{"issue":"11","key":"3684_CR76","doi-asserted-by":"publisher","first-page":"2197","DOI":"10.1007\/s11064-008-9670-4","volume":"33","author":"Z Jia","year":"2008","unstructured":"Jia Z, Zhu H, Misra BR, Li Y, Misra HP (2008) Dopamine as a potent inducer of cellular glutathione and NAD(P)H:quinone oxidoreductase 1 in PC12 neuronal cells: a potential adaptive mechanism for dopaminergic neuroprotection. Neurochem Res 33(11):2197\u20132205","journal-title":"Neurochem Res"},{"issue":"4","key":"3684_CR77","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.1046\/j.1471-4159.1995.64041742.x","volume":"64","author":"TA Newcomer","year":"1995","unstructured":"Newcomer TA, Rosenberg PA, Aizenman E (1995) Iron-mediated oxidation of 3,4-dihydroxyphenylalanine to an excitotoxin. J Neurochem 64(4):1742\u20131748","journal-title":"J Neurochem"},{"issue":"4","key":"3684_CR78","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3390\/toxics6040065","volume":"6","author":"BO Anyanwu","year":"2018","unstructured":"Anyanwu BO, Ezejiofor AN, Igweze ZN, Orisakwe OE (2018) Heavy metal mixture exposure and effects in developing nations: an update. Toxics 6(4):65","journal-title":"Toxics"},{"issue":"1","key":"3684_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0306-4522(93)90175-F","volume":"52","author":"P Damier","year":"1993","unstructured":"Damier P, Hirsch EC, Zhang P, Agid Y, Javoy-Agid F (1993) Glutathione peroxidase, glial cells and Parkinson\u2019s disease. Neuroscience 52(1):1\u20136","journal-title":"Neuroscience"},{"issue":"6","key":"3684_CR80","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1002\/(SICI)1097-4547(19990315)55:6<659::AID-JNR1>3.0.CO;2-C","volume":"55","author":"AH Stokes","year":"1999","unstructured":"Stokes AH, Hastings TG, Vrana KE (1999) Cytotoxic and genotoxic potential of dopamine. J Neurosci Res 55(6):659\u2013665","journal-title":"J Neurosci Res"},{"issue":"1","key":"3684_CR81","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/0163-7258(94)90055-8","volume":"63","author":"ME Gotz","year":"1994","unstructured":"Gotz ME, Kunig G, Riederer P, Youdim MB (1994) Oxidative stress: free radical production in neural degeneration. Pharmacol Ther 63(1):37\u2013122","journal-title":"Pharmacol Ther"},{"issue":"5","key":"3684_CR82","doi-asserted-by":"publisher","first-page":"684","DOI":"10.1016\/j.neuint.2012.12.004","volume":"62","author":"GF Allen","year":"2013","unstructured":"Allen GF, Ullah Y, Hargreaves IP, Land JM, Heales SJ (2013) Dopamine but not l-dopa stimulates neural glutathione metabolism. Potential implications for Parkinson\u2019s and other dopamine deficiency states. Neurochem Int 62(5):684\u2013694","journal-title":"Neurochem Int"},{"issue":"Suppl 3","key":"3684_CR83","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1002\/ana.10483","volume":"53","author":"P Jenner","year":"2003","unstructured":"Jenner P (2003) Oxidative stress in Parkinson\u2019s disease. Ann Neurol 53(Suppl 3):S26-36 (discussion S36-8)","journal-title":"Ann Neurol"},{"issue":"9","key":"3684_CR84","doi-asserted-by":"publisher","first-page":"4676","DOI":"10.3390\/ijms22094676","volume":"22","author":"K Badanjak","year":"2021","unstructured":"Badanjak K, Fixemer S, Smajic S, Skupin A, Grunewald A (2021) The contribution of microglia to neuroinflammation in Parkinson\u2019s disease. Int J Mol Sci 22(9):4676","journal-title":"Int J Mol Sci"},{"key":"3684_CR85","doi-asserted-by":"publisher","first-page":"593026","DOI":"10.3389\/fphys.2020.593026","volume":"11","author":"S Al-Bachari","year":"2020","unstructured":"Al-Bachari S, Naish JH, Parker GJM, Emsley HCA, Parkes LM (2020) Blood-brain barrier leakage is increased in Parkinson\u2019s disease. Front Physiol 11:593026","journal-title":"Front Physiol"},{"issue":"25","key":"3684_CR86","doi-asserted-by":"publisher","first-page":"2766","DOI":"10.2174\/138161210793176572","volume":"16","author":"P Agostinho","year":"2010","unstructured":"Agostinho P, Cunha RA, Oliveira C (2010) Neuroinflammation, oxidative stress and the pathogenesis of Alzheimer\u2019s disease. Curr Pharm Des 16(25):2766\u20132778","journal-title":"Curr Pharm Des"},{"issue":"3","key":"3684_CR87","doi-asserted-by":"publisher","first-page":"e12782","DOI":"10.1111\/nan.12782","volume":"48","author":"C Kurz","year":"2022","unstructured":"Kurz C, Walker L, Rauchmann BS, Perneczky R (2022) Dysfunction of the blood-brain barrier in Alzheimer\u2019s disease: evidence from human studies. Neuropathol Appl Neurobiol 48(3):e12782","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"5","key":"3684_CR88","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1016\/j.celrep.2019.09.066","volume":"29","author":"OH Tam","year":"2019","unstructured":"Tam OH, Rozhkov NV, Shaw R, Kim D, Hubbard I, Fennessey S, Propp N, Consortium NA et al (2019) Postmortem cortex samples identify distinct molecular subtypes of ALS: retrotransposon activation, oxidative stress, and activated glia. Cell Rep 29(5):1164-1177 e5","journal-title":"Cell Rep"},{"key":"3684_CR89","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.brainres.2012.05.056","volume":"1469","author":"S Garbuzova-Davis","year":"2012","unstructured":"Garbuzova-Davis S, Hernandez-Ontiveros DG, Rodrigues MC, Haller E, Frisina-Deyo A, Mirtyl S, Sallot S, Saporta S et al (2012) Impaired blood-brain\/spinal cord barrier in ALS patients. Brain Res 1469:114\u2013128","journal-title":"Brain Res"},{"issue":"24","key":"3684_CR90","doi-asserted-by":"publisher","first-page":"6413","DOI":"10.1523\/JNEUROSCI.3815-05.2006","volume":"26","author":"JB Kim","year":"2006","unstructured":"Kim JB, Sig Choi J, Yu YM, Nam K, Piao CS, Kim SW, Lee MH, Han PL et al (2006) HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci 26(24):6413\u201321","journal-title":"J Neurosci"},{"key":"3684_CR91","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.pneurobio.2014.06.002","volume":"119\u2013120","author":"X Hu","year":"2014","unstructured":"Hu X, Liou AK, Leak RK, Xu M, An C, Suenaga J, Shi Y, Gao Y et al (2014) Neurobiology of microglial action in CNS injuries: receptor-mediated signaling mechanisms and functional roles. Prog Neurobiol 119\u2013120:60\u201384","journal-title":"Prog Neurobiol"},{"issue":"12","key":"3684_CR92","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1002\/sctm.19-0159","volume":"8","author":"SJ Chan","year":"2019","unstructured":"Chan SJ, Niu W, Hayakawa K, Hamanaka G, Wang X, Cheah PS, Guo S, Yu Z et al (2019) Promoting neuro-supportive properties of astrocytes with epidermal growth factor hydrogels. Stem Cells Transl Med 8(12):1242\u20131248","journal-title":"Stem Cells Transl Med"},{"issue":"3","key":"3684_CR93","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1002\/glia.21112","volume":"59","author":"I Miyazaki","year":"2011","unstructured":"Miyazaki I, Asanuma M, Kikkawa Y, Takeshima M, Murakami S, Miyoshi K, Sogawa N, Kita T (2011) Astrocyte-derived metallothionein protects dopaminergic neurons from dopamine quinone toxicity. Glia 59(3):435\u2013451","journal-title":"Glia"},{"issue":"5","key":"3684_CR94","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuint.2005.12.001","volume":"48","author":"JH Yi","year":"2006","unstructured":"Yi JH, Hazell AS (2006) Excitotoxic mechanisms and the role of astrocytic glutamate transporters in traumatic brain injury. Neurochem Int 48(5):394\u2013403","journal-title":"Neurochem Int"},{"issue":"10","key":"3684_CR95","doi-asserted-by":"publisher","first-page":"2059","DOI":"10.1002\/jnr.21325","volume":"85","author":"S Tilleux","year":"2007","unstructured":"Tilleux S, Hermans E (2007) Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J Neurosci Res 85(10):2059\u20132070","journal-title":"J Neurosci Res"},{"key":"3684_CR96","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1186\/1742-2094-9-275","volume":"9","author":"J Takaki","year":"2012","unstructured":"Takaki J, Fujimori K, Miura M, Suzuki T, Sekino Y, Sato K (2012) L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the \u2018collusion\u2019 hypothesis for increased extracellular L-glutamate concentration in neuroinflammation. J Neuroinflammation 9:275","journal-title":"J Neuroinflammation"},{"key":"3684_CR97","doi-asserted-by":"publisher","first-page":"e17","DOI":"10.1017\/S1462399409001094","volume":"11","author":"MR Vargas","year":"2009","unstructured":"Vargas MR, Johnson JA (2009) The Nrf2-ARE cytoprotective pathway in astrocytes. Expert Rev Mol Med 11:e17","journal-title":"Expert Rev Mol Med"},{"key":"3684_CR98","doi-asserted-by":"publisher","first-page":"107179","DOI":"10.1016\/j.intimp.2020.107179","volume":"90","author":"S Li","year":"2021","unstructured":"Li S, Zhou C, Zhu Y, Chao Z, Sheng Z, Zhang Y, Zhao Y (2021) Ferrostatin-1 alleviates angiotensin II (Ang II)-induced inflammation and ferroptosis in astrocytes. Int Immunopharmacol 90:107179","journal-title":"Int Immunopharmacol"},{"issue":"1","key":"3684_CR99","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.brainres.2004.09.014","volume":"1029","author":"I Miyazaki","year":"2004","unstructured":"Miyazaki I, Asanuma M, Diaz-Corrales FJ, Miyoshi K, Ogawa N (2004) Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia. Brain Res 1029(1):120\u2013123","journal-title":"Brain Res"},{"issue":"3","key":"3684_CR100","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1046\/j.1471-4159.2001.00068.x","volume":"76","author":"N Furukawa","year":"2001","unstructured":"Furukawa N, Arai N, Goshima Y, Miyamae T, Ohshima E, Suzuki F, Fujita K, Misu Y (2001) Endogenously released DOPA is a causal factor for glutamate release and resultant delayed neuronal cell death by transient ischemia in rat striata. J Neurochem 76(3):815\u2013824","journal-title":"J Neurochem"},{"issue":"9","key":"3684_CR101","doi-asserted-by":"publisher","first-page":"e106362","DOI":"10.1371\/journal.pone.0106362","volume":"9","author":"M Asanuma","year":"2014","unstructured":"Asanuma M, Miyazaki I, Murakami S, Diaz-Corrales FJ, Ogawa N (2014) Striatal astrocytes act as a reservoir for L-DOPA. PLoS ONE 9(9):e106362","journal-title":"PLoS ONE"},{"issue":"3","key":"3684_CR102","doi-asserted-by":"publisher","first-page":"266","DOI":"10.4161\/auto.7.3.14348","volume":"7","author":"W Springer","year":"2011","unstructured":"Springer W, Kahle PJ (2011) Regulation of PINK1-Parkin-mediated mitophagy. Autophagy 7(3):266\u2013278","journal-title":"Autophagy"},{"issue":"R2","key":"3684_CR103","doi-asserted-by":"publisher","first-page":"R169","DOI":"10.1093\/hmg\/ddp326","volume":"18","author":"H Chen","year":"2009","unstructured":"Chen H, Chan DC (2009) Mitochondrial dynamics\u2013fusion, fission, movement, and mitophagy\u2013in neurodegenerative diseases. Hum Mol Genet 18(R2):R169\u2013R176","journal-title":"Hum Mol Genet"},{"issue":"10","key":"3684_CR104","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1038\/s41593-019-0486-0","volume":"22","author":"AU Joshi","year":"2019","unstructured":"Joshi AU, Minhas PS, Liddelow SA, Haileselassie B, Andreasson KI, Dorn GW 2nd, Mochly-Rosen D (2019) Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration. Nat Neurosci 22(10):1635\u20131648","journal-title":"Nat Neurosci"},{"issue":"12","key":"3684_CR105","doi-asserted-by":"publisher","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","volume":"164","author":"CD Mills","year":"2000","unstructured":"Mills CD, Kincaid K, Alt JM, Heilman MJ, Hill AM (2000) M-1\/M-2 macrophages and the Th1\/Th2 paradigm. J Immunol 164(12):6166\u20136173","journal-title":"J Immunol"},{"issue":"2","key":"3684_CR106","doi-asserted-by":"publisher","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","volume":"53","author":"Y Tang","year":"2016","unstructured":"Tang Y, Le W (2016) Differential roles of M1 and M2 microglia in neurodegenerative diseases. Mol Neurobiol 53(2):1181\u20131194","journal-title":"Mol Neurobiol"},{"issue":"5","key":"3684_CR107","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1002\/1873-3468.12956","volume":"592","author":"N Nissanka","year":"2018","unstructured":"Nissanka N, Moraes CT (2018) Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease. FEBS Lett 592(5):728\u2013742","journal-title":"FEBS Lett"},{"key":"3684_CR108","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/s41531-017-0032-2","volume":"3","author":"S Sarkar","year":"2017","unstructured":"Sarkar S, Malovic E, Harishchandra DS, Ghaisas S, Panicker N, Charli A, Palanisamy BN, Rokad D et al (2017) Mitochondrial impairment in microglia amplifies NLRP3 inflammasome proinflammatory signaling in cell culture and animal models of Parkinson\u2019s disease. NPJ Parkinsons Dis 3:30","journal-title":"NPJ Parkinsons Dis"},{"issue":"4","key":"3684_CR109","doi-asserted-by":"publisher","first-page":"891","DOI":"10.1042\/BST20170501","volume":"46","author":"R Macdonald","year":"2018","unstructured":"Macdonald R, Barnes K, Hastings C, Mortiboys H (2018) Mitochondrial abnormalities in Parkinson\u2019s disease and Alzheimer\u2019s disease: can mitochondria be targeted therapeutically? Biochem Soc Trans 46(4):891\u2013909","journal-title":"Biochem Soc Trans"},{"issue":"26","key":"3684_CR110","doi-asserted-by":"publisher","first-page":"9633","DOI":"10.1073\/pnas.1404651111","volume":"111","author":"CH Davis","year":"2014","unstructured":"Davis CH, Kim KY, Bushong EA, Mills EA, Boassa D, Shih T, Kinebuchi M, Phan S et al (2014) Transcellular degradation of axonal mitochondria. Proc Natl Acad Sci U S A 111(26):9633\u20139638","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3684_CR111","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1007\/s11481-014-9552-2","volume":"9","author":"S Khasnavis","year":"2014","unstructured":"Khasnavis S, Pahan K (2014) Cinnamon treatment upregulates neuroprotective proteins Parkin and DJ-1 and protects dopaminergic neurons in a mouse model of Parkinson\u2019s disease. J Neuroimmune Pharmacol 9(4):569\u2013581","journal-title":"J Neuroimmune Pharmacol"},{"issue":"7","key":"3684_CR112","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1212\/WNL.62.7.1058","volume":"62","author":"R Pons","year":"2004","unstructured":"Pons R, Ford B, Chiriboga CA, Clayton PT, Hinton V, Hyland K, Sharma R, De Vivo DC (2004) Aromatic L-amino acid decarboxylase deficiency: clinical features, treatment, and prognosis. Neurology 62(7):1058\u20131065","journal-title":"Neurology"},{"issue":"2","key":"3684_CR113","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.ejpn.2008.03.008","volume":"13","author":"HF Lee","year":"2009","unstructured":"Lee HF, Tsai CR, Chi CS, Chang TM, Lee HJ (2009) Aromatic L-amino acid decarboxylase deficiency in Taiwan. Eur J Paediatr Neurol 13(2):135\u2013140","journal-title":"Eur J Paediatr Neurol"},{"issue":"3","key":"3684_CR114","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1002\/hbm.23470","volume":"38","author":"WT Lee","year":"2017","unstructured":"Lee WT, Lin JH, Weng WC, Peng SS (2017) Microstructural changes of brain in patients with aromatic L-amino acid decarboxylase deficiency. Hum Brain Mapp 38(3):1532\u20131540","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"3684_CR115","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1080\/10715760902751902","volume":"43","author":"PB Pun","year":"2009","unstructured":"Pun PB, Lu J, Moochhala S (2009) Involvement of ROS in BBB dysfunction. Free Radic Res 43(4):348\u2013364","journal-title":"Free Radic Res"},{"issue":"5","key":"3684_CR116","doi-asserted-by":"publisher","first-page":"1361","DOI":"10.1093\/brain\/awab003","volume":"144","author":"J Walsh","year":"2021","unstructured":"Walsh J, Tozer DJ, Sari H, Hong YT, Drazyk A, Williams G, Shah NJ, O\u2019Brien JT et al (2021) Microglial activation and blood-brain barrier permeability in cerebral small vessel disease. Brain 144(5):1361\u20131371","journal-title":"Brain"},{"issue":"2","key":"3684_CR117","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1182\/blood-2005-06-2506","volume":"107","author":"AF Kamath","year":"2006","unstructured":"Kamath AF, Chauhan AK, Kisucka J, Dole VS, Loscalzo J, Handy DE, Wagner DD (2006) Elevated levels of homocysteine compromise blood-brain barrier integrity in mice. Blood 107(2):591\u2013593","journal-title":"Blood"},{"issue":"1","key":"3684_CR118","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1038\/nrn1824","volume":"7","author":"NJ Abbott","year":"2006","unstructured":"Abbott NJ, Ronnback L, Hansson E (2006) Astrocyte-endothelial interactions at the blood-brain barrier. Nat Rev Neurosci 7(1):41\u201353","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"3684_CR119","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1038\/jcbfm.2015.32","volume":"35","author":"MT Gray","year":"2015","unstructured":"Gray MT, Woulfe JM (2015) Striatal blood-brain barrier permeability in Parkinson\u2019s disease. J Cereb Blood Flow Metab 35(5):747\u2013750","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"3684_CR120","doi-asserted-by":"publisher","first-page":"e76310","DOI":"10.1371\/journal.pone.0076310","volume":"8","author":"DF Aschauer","year":"2013","unstructured":"Aschauer DF, Kreuz S, Rumpel S (2013) Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain. PLoS ONE 8(9):e76310","journal-title":"PLoS ONE"},{"issue":"1","key":"3684_CR121","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0006-8993(97)00908-6","volume":"771","author":"T Maeda","year":"1997","unstructured":"Maeda T, Cheng N, Kume T, Kaneko S, Kouchiyama H, Akaike A, Ueda M, Satoh M et al (1997) L-DOPA neurotoxicity is mediated by glutamate release in cultured rat striatal neurons. Brain Res 771(1):159\u2013162","journal-title":"Brain Res"},{"issue":"1","key":"3684_CR122","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/0006-8993(93)90631-V","volume":"617","author":"Y Goshima","year":"1993","unstructured":"Goshima Y, Ohno K, Nakamura S, Miyamae T, Misu Y, Akaike A (1993) L-dopa induces Ca(2+)-dependent and tetrodotoxin-sensitive release of endogenous glutamate from rat striatal slices. Brain Res 617(1):167\u2013170","journal-title":"Brain Res"},{"issue":"10","key":"3684_CR123","doi-asserted-by":"publisher","first-page":"3343","DOI":"10.1523\/JNEUROSCI.07-10-03343.1987","volume":"7","author":"R Gill","year":"1987","unstructured":"Gill R, Foster AC, Woodruff GN (1987) Systemic administration of MK-801 protects against ischemia-induced hippocampal neurodegeneration in the gerbil. J Neurosci 7(10):3343\u20133349","journal-title":"J Neurosci"},{"issue":"4942","key":"3684_CR124","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1126\/science.2154034","volume":"247","author":"MJ Sheardown","year":"1990","unstructured":"Sheardown MJ, Nielsen EO, Hansen AJ, Jacobsen P, Honore T (1990) 2,3-Dihydroxy-6-nitro-7-sulfamoyl-benzo(F)quinoxaline: a neuroprotectant for cerebral ischemia. Science 247(4942):571\u2013574","journal-title":"Science"},{"issue":"8","key":"3684_CR125","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1038\/sj.bjp.0704982","volume":"137","author":"R Pedrosa","year":"2002","unstructured":"Pedrosa R, Soares-da-Silva P (2002) Oxidative and non-oxidative mechanisms of neuronal cell death and apoptosis by L-3,4-dihydroxyphenylalanine (L-DOPA) and dopamine. Br J Pharmacol 137(8):1305\u20131313","journal-title":"Br J Pharmacol"},{"issue":"2","key":"3684_CR126","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s12640-011-9263-x","volume":"21","author":"K Golembiowska","year":"2012","unstructured":"Golembiowska K, Dziubina A (2012) Effect of adenosine A(2A) receptor antagonists and L-DOPA on hydroxyl radical, glutamate and dopamine in the striatum of 6-OHDA-treated rats. Neurotox Res 21(2):222\u2013230","journal-title":"Neurotox Res"},{"issue":"1","key":"3684_CR127","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.expneurol.2011.09.029","volume":"238","author":"SW Chan","year":"2012","unstructured":"Chan SW, Dunlop RA, Rowe A, Double KL, Rodgers KJ (2012) L-DOPA is incorporated into brain proteins of patients treated for Parkinson\u2019s disease, inducing toxicity in human neuroblastoma cells in vitro. Exp Neurol 238(1):29\u201337","journal-title":"Exp Neurol"},{"key":"3684_CR128","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1146\/annurev-cellbio-100617-062636","volume":"34","author":"AA Davis","year":"2018","unstructured":"Davis AA, Leyns CEG, Holtzman DM (2018) Intercellular spread of protein aggregates in neurodegenerative disease. Annu Rev Cell Dev Biol 34:545\u2013568","journal-title":"Annu Rev Cell Dev Biol"},{"key":"3684_CR129","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.neuropharm.2012.11.010","volume":"67","author":"BJ Stansley","year":"2013","unstructured":"Stansley BJ, Yamamoto BK (2013) L-dopa-induced dopamine synthesis and oxidative stress in serotonergic cells. Neuropharmacology 67:243\u2013251","journal-title":"Neuropharmacology"},{"issue":"5","key":"3684_CR130","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1046\/j.1471-4159.2001.00184.x","volume":"76","author":"K Kannari","year":"2001","unstructured":"Kannari K, Yamato H, Shen H, Tomiyama M, Suda T, Matsunaga M (2001) Activation of 5-HT(1A) but not 5-HT(1B) receptors attenuates an increase in extracellular dopamine derived from exogenously administered L-DOPA in the striatum with nigrostriatal denervation. J Neurochem 76(5):1346\u20131353","journal-title":"J Neurochem"},{"issue":"2","key":"3684_CR131","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1016\/j.nbd.2010.11.007","volume":"41","author":"S Navailles","year":"2011","unstructured":"Navailles S, Bioulac B, Gross C, De Deurwaerdere P (2011) Chronic L-DOPA therapy alters central serotonergic function and L-DOPA-induced dopamine release in a region-dependent manner in a rat model of Parkinson\u2019s disease. Neurobiol Dis 41(2):585\u2013590","journal-title":"Neurobiol Dis"},{"issue":"17","key":"3684_CR132","doi-asserted-by":"publisher","first-page":"3203","DOI":"10.1007\/s00213-015-3980-4","volume":"232","author":"BJ Stansley","year":"2015","unstructured":"Stansley BJ, Yamamoto BK (2015) Behavioral impairments and serotonin reductions in rats after chronic L-dopa. Psychopharmacology 232(17):3203\u20133213","journal-title":"Psychopharmacology"},{"issue":"1","key":"3684_CR133","doi-asserted-by":"publisher","first-page":"75","DOI":"10.3390\/toxics3010075","volume":"3","author":"BJ Stansley","year":"2015","unstructured":"Stansley BJ, Yamamoto BK (2015) L-dopa and brain serotonin system dysfunction. Toxics 3(1):75\u201388","journal-title":"Toxics"},{"issue":"4","key":"3684_CR134","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1016\/j.bbadis.2015.12.012","volume":"1862","author":"M Kalogiannis","year":"2016","unstructured":"Kalogiannis M, Delikatny EJ, Jeitner TM (2016) Serotonin as a putative scavenger of hypohalous acid in the brain. Biochim Biophys Acta 1862(4):651\u2013661","journal-title":"Biochim Biophys Acta"},{"key":"3684_CR135","first-page":"139","volume":"79","author":"C Xia","year":"2018","unstructured":"Xia C, Tong X (2018) Moschamine-related indole alkaloids, Alkaloids. Chem Biol 79:139\u2013189","journal-title":"Chem Biol"},{"key":"3684_CR136","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/j.nbd.2013.08.003","volume":"59","author":"I Miyazaki","year":"2013","unstructured":"Miyazaki I, Asanuma M, Murakami S, Takeshima M, Torigoe N, Kitamura Y, Miyoshi K (2013) Targeting 5-HT(1A) receptors in astrocytes to protect dopaminergic neurons in Parkinsonian models. Neurobiol Dis 59:244\u2013256","journal-title":"Neurobiol Dis"},{"issue":"7","key":"3684_CR137","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.3390\/cells10071603","volume":"10","author":"A Mor","year":"2021","unstructured":"Mor A, Tankiewicz-Kwedlo A, Krupa A, Pawlak D (2021) Role of kynurenine pathway in oxidative stress during neurodegenerative disorders. Cells 10(7):1603","journal-title":"Cells"},{"issue":"1","key":"3684_CR138","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1111\/j.1600-079X.2004.00177.x","volume":"38","author":"C Keithahn","year":"2005","unstructured":"Keithahn C, Lerchl A (2005) 5-Hydroxytryptophan is a more potent in vitro hydroxyl radical scavenger than melatonin or vitamin C. J Pineal Res 38(1):62\u201366","journal-title":"J Pineal Res"},{"issue":"1\u20132","key":"3684_CR139","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/S0006-8993(00)02158-2","volume":"863","author":"P Soares-da-Silva","year":"2000","unstructured":"Soares-da-Silva P, Parada A, Serrao P (2000) The O-methylated derivative of L-DOPA, 3-O-methyl-L-DOPA, fails to inhibit neuronal and non-neuronal aromatic L-amino acid decarboxylase. Brain Res 863(1\u20132):293\u2013297","journal-title":"Brain Res"},{"issue":"1\u20132","key":"3684_CR140","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/S0169-328X(99)00238-7","volume":"73","author":"DM Kuhn","year":"1999","unstructured":"Kuhn DM, Arthur RE Jr (1999) L-DOPA-quinone inactivates tryptophan hydroxylase and converts the enzyme to a redox-cycling quinoprotein. Brain Res Mol Brain Res 73(1\u20132):78\u201384","journal-title":"Brain Res Mol Brain Res"},{"issue":"11","key":"3684_CR141","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/nm1314","volume":"11","author":"MJ LaVoie","year":"2005","unstructured":"LaVoie MJ, Ostaszewski BL, Weihofen A, Schlossmacher MG, Selkoe DJ (2005) Dopamine covalently modifies and functionally inactivates parkin. Nat Med 11(11):1214\u20131221","journal-title":"Nat Med"},{"issue":"10","key":"3684_CR142","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.3390\/ijms17101733","volume":"17","author":"H Skovierova","year":"2016","unstructured":"Skovierova H, Vidomanova E, Mahmood S, Sopkova J, Drgova A, Cervenova T, Halasova E, Lehotsky J (2016) The molecular and cellular effect of homocysteine metabolism imbalance on human health. Int J Mol Sci 17(10):1733","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3684_CR143","doi-asserted-by":"publisher","first-page":"231","DOI":"10.3390\/ijms20010231","volume":"20","author":"R Moretti","year":"2019","unstructured":"Moretti R, Caruso P (2019) The controversial role of homocysteine in neurology: from labs to clinical practice. Int J Mol Sci 20(1):231","journal-title":"Int J Mol Sci"},{"issue":"12","key":"3684_CR144","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1515\/CCLM.2007.356","volume":"45","author":"R Obeid","year":"2007","unstructured":"Obeid R, McCaddon A, Herrmann W (2007) The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases. Clin Chem Lab Med 45(12):1590\u20131606","journal-title":"Clin Chem Lab Med"},{"issue":"6","key":"3684_CR145","doi-asserted-by":"publisher","first-page":"627","DOI":"10.1007\/s00210-011-0629-7","volume":"383","author":"T Muller","year":"2011","unstructured":"Muller T, Woitalla D, Muhlack S (2011) Inhibition of catechol-O-methyltransferase modifies acute homocysteine rise during repeated levodopa application in patients with Parkinson\u2019s disease. Naunyn Schmiedebergs Arch Pharmacol 383(6):627\u2013633","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"3684_CR146","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s007020200013","volume":"109","author":"T Muller","year":"2002","unstructured":"Muller T, Woitalla D, Fowler B, Kuhn W (2002) 3-OMD and homocysteine plasma levels in parkinsonian patients. J Neural Transm (Vienna) 109(2):175\u2013179","journal-title":"J Neural Transm (Vienna)"},{"issue":"7","key":"3684_CR147","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1212\/01.WNL.0000055899.24594.8E","volume":"60","author":"JW Miller","year":"2003","unstructured":"Miller JW, Selhub J, Nadeau MR, Thomas CA, Feldman RG, Wolf PA (2003) Effect of L-dopa on plasma homocysteine in PD patients: relationship to B-vitamin status. Neurology 60(7):1125\u20131129","journal-title":"Neurology"},{"issue":"13","key":"3684_CR148","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1016\/j.febslet.2006.04.088","volume":"580","author":"R Obeid","year":"2006","unstructured":"Obeid R, Herrmann W (2006) Mechanisms of homocysteine neurotoxicity in neurodegenerative diseases with special reference to dementia. FEBS Lett 580(13):2994\u20133005","journal-title":"FEBS Lett"},{"key":"3684_CR149","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1016\/j.neuint.2018.07.010","volume":"120","author":"M Kumar","year":"2018","unstructured":"Kumar M, Ray RS, Sandhir R (2018) Hydrogen sulfide attenuates homocysteine-induced neurotoxicity by preventing mitochondrial dysfunctions and oxidative damage: in vitro and in vivo studies. Neurochem Int 120:87\u201398","journal-title":"Neurochem Int"},{"issue":"2","key":"3684_CR150","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11011-010-9188-8","volume":"25","author":"AA da Cunha","year":"2010","unstructured":"da Cunha AA, Ferreira AG, Wyse AT (2010) Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration. Metab Brain Dis 25(2):199\u2013206","journal-title":"Metab Brain Dis"},{"key":"3684_CR151","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.neuroscience.2013.07.051","volume":"252","author":"PK Kamat","year":"2013","unstructured":"Kamat PK, Kalani A, Givvimani S, Sathnur PB, Tyagi SC, Tyagi N (2013) Hydrogen sulfide attenuates neurodegeneration and neurovascular dysfunction induced by intracerebral-administered homocysteine in mice. Neuroscience 252:302\u2013319","journal-title":"Neuroscience"},{"key":"3684_CR152","doi-asserted-by":"publisher","first-page":"119386","DOI":"10.1016\/j.lfs.2021.119386","volume":"277","author":"TM Dos Santos","year":"2021","unstructured":"Dos Santos TM, Ramires Junior OV, Alves VS, Coutinho-Silva R, Savio LEB, Wyse ATS (2021) Hyperhomocysteinemia alters cytokine gene expression, cytochrome c oxidase activity and oxidative stress in striatum and cerebellum of rodents. Life Sci 277:119386","journal-title":"Life Sci"},{"key":"3684_CR153","first-page":"47","volume":"6","author":"N Bhattacharjee","year":"2016","unstructured":"Bhattacharjee N, Paul R, Giri A, Borah A (2016) Chronic exposure of homocysteine in mice contributes to dopamine loss by enhancing oxidative stress in nigrostriatum and produces behavioral phenotypes of Parkinson\u2019s disease. Biochem Biophys Rep 6:47\u201353","journal-title":"Biochem Biophys Rep"},{"issue":"5","key":"3684_CR154","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1002\/mds.27301","volume":"33","author":"CW Christine","year":"2018","unstructured":"Christine CW, Auinger P, Joslin A, Yelpaala Y, Green R, D.I. Parkinson Study Group (2018) Vitamin B12 and homocysteine levels predict different outcomes in early Parkinson\u2019s disease. Mov Disord 33(5):762\u2013770","journal-title":"Mov Disord"},{"issue":"5","key":"3684_CR155","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/jnc.12345","volume":"126","author":"DS Goldstein","year":"2013","unstructured":"Goldstein DS, Sullivan P, Holmes C, Miller GW, Alter S, Strong R, Mash DC, Kopin IJ et al (2013) Determinants of buildup of the toxic dopamine metabolite DOPAL in Parkinson\u2019s disease. J Neurochem 126(5):591\u2013603","journal-title":"J Neurochem"},{"key":"3684_CR156","first-page":"271","volume":"45","author":"W Gsell","year":"1995","unstructured":"Gsell W, Reichert N, Youdim MB, Riederer P (1995) Interaction of neuroprotective substances with human brain superoxide dismutase. An in vitro study. J Neural Transm Suppl 45:271\u2013279","journal-title":"J Neural Transm Suppl"},{"issue":"9","key":"3684_CR157","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1139\/cjpp-2020-0507","volume":"99","author":"M Chu","year":"2021","unstructured":"Chu M, Teng J, Guo L, Wang Y, Zhang L, Gao J, Liu L (2021) Mild hyperhomocysteinemia induces blood-brain barrier dysfunction but not neuroinflammation in the cerebral cortex and hippocampus of wild-type mice. Can J Physiol Pharmacol 99(9):847\u2013856","journal-title":"Can J Physiol Pharmacol"},{"issue":"7","key":"3684_CR158","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.1093\/clinchem\/39.7.1390","volume":"39","author":"AB Guttormsen","year":"1993","unstructured":"Guttormsen AB, Mansoor AM, Fiskerstrand T, Ueland PM, Refsum H (1993) Kinetics of plasma homocysteine in healthy subjects after peroral homocysteine loading. Clin Chem 39(7):1390\u20131397","journal-title":"Clin Chem"},{"issue":"11","key":"3684_CR159","doi-asserted-by":"publisher","first-page":"5923","DOI":"10.1073\/pnas.94.11.5923","volume":"94","author":"SA Lipton","year":"1997","unstructured":"Lipton SA, Kim WK, Choi YB, Kumar S, D\u2019Emilia DM, Rayudu PV, Arnelle DR, Stamler JS (1997) Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor. Proc Natl Acad Sci U S A 94(11):5923\u20135928","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"3684_CR160","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1007\/BF03033381","volume":"5","author":"A Jara-Prado","year":"2003","unstructured":"Jara-Prado A, Ortega-Vazquez A, Martinez-Ruano L, Rios C, Santamaria A (2003) Homocysteine-induced brain lipid peroxidation: effects of NMDA receptor blockade, antioxidant treatment, and nitric oxide synthase inhibition. Neurotox Res 5(4):237\u2013243","journal-title":"Neurotox Res"},{"key":"3684_CR161","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/978-3-319-55769-4_4","volume":"16","author":"F Zafra","year":"2017","unstructured":"Zafra F, Ibanez I, Bartolome-Martin D, Piniella D, Arribas-Blazquez M, Gimenez C (2017) Glycine transporters and its coupling with NMDA receptors. Adv Neurobiol 16:55\u201383","journal-title":"Adv Neurobiol"},{"issue":"2","key":"3684_CR162","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1006\/exnr.1994.1213","volume":"130","author":"J Folbergrova","year":"1994","unstructured":"Folbergrova J (1994) NMDA and not non-NMDA receptor antagonists are protective against seizures induced by homocysteine in neonatal rats. Exp Neurol 130(2):344\u2013350","journal-title":"Exp Neurol"},{"issue":"2","key":"3684_CR163","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1111\/jnc.13885","volume":"140","author":"C Cervetto","year":"2017","unstructured":"Cervetto C, Venturini A, Passalacqua M, Guidolin D, Genedani S, Fuxe K, Borroto-Esquela DO, Cortelli P et al (2017) A2A\u2013D2 receptor-receptor interaction modulates gliotransmitter release from striatal astrocyte processes. J Neurochem 140(2):268\u2013279","journal-title":"J Neurochem"},{"issue":"4","key":"3684_CR164","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1007\/s12031-018-1120-4","volume":"65","author":"C Cervetto","year":"2018","unstructured":"Cervetto C, Venturini A, Guidolin D, Maura G, Passalacqua M, Tacchetti C, Cortelli P, Genedani S et al (2018) Homocysteine and A2A\u2013D2 receptor-receptor interaction at striatal astrocyte processes. J Mol Neurosci 65(4):456\u2013466","journal-title":"J Mol Neurosci"},{"issue":"4","key":"3684_CR165","doi-asserted-by":"publisher","first-page":"931","DOI":"10.1016\/0092-8674(77)90157-X","volume":"12","author":"NM Kredich","year":"1977","unstructured":"Kredich NM, Martin DV Jr (1977) Role of S-adenosylhomocysteine in adenosinemediated toxicity in cultured mouse T lymphoma cells. Cell 12(4):931\u2013938","journal-title":"Cell"},{"issue":"6","key":"3684_CR166","doi-asserted-by":"publisher","first-page":"471","DOI":"10.2165\/00002512-200522060-00002","volume":"22","author":"RA Hauser","year":"2005","unstructured":"Hauser RA, Schwarzschild MA (2005) Adenosine A2A receptor antagonists for Parkinson\u2019s disease: rationale, therapeutic potential and clinical experience. Drugs Aging 22(6):471\u2013482","journal-title":"Drugs Aging"},{"issue":"13","key":"3684_CR167","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1096\/fj.05-3724fje","volume":"19","author":"Y Enokido","year":"2005","unstructured":"Enokido Y, Suzuki E, Iwasawa K, Namekata K, Okazawa H, Kimura H (2005) Cystathionine beta-synthase, a key enzyme for homocysteine metabolism, is preferentially expressed in the radial glia\/astrocyte lineage of developing mouse CNS. FASEB J 19(13):1854\u20131856","journal-title":"FASEB J"},{"issue":"1","key":"3684_CR168","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1089\/ars.2011.4345","volume":"17","author":"H Kimura","year":"2012","unstructured":"Kimura H, Shibuya N, Kimura Y (2012) Hydrogen sulfide is a signaling molecule and a cytoprotectant. Antioxid Redox Signal 17(1):45\u201357","journal-title":"Antioxid Redox Signal"},{"issue":"4","key":"3684_CR169","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1089\/ars.2008.2253","volume":"11","author":"N Shibuya","year":"2009","unstructured":"Shibuya N, Tanaka M, Yoshida M, Ogasawara Y, Togawa T, Ishii K, Kimura H (2009) 3-Mercaptopyruvate sulfurtransferase produces hydrogen sulfide and bound sulfane sulfur in the brain. Antioxid Redox Signal 11(4):703\u2013714","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"3684_CR170","doi-asserted-by":"publisher","first-page":"755","DOI":"10.3945\/an.112.002758","volume":"3","author":"KL Schalinske","year":"2012","unstructured":"Schalinske KL, Smazal AL (2012) Homocysteine imbalance: a pathological metabolic marker. Adv Nutr 3(6):755\u2013762","journal-title":"Adv Nutr"},{"key":"3684_CR171","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/978-3-319-18144-8_10","volume":"230","author":"BV Nagpure","year":"2015","unstructured":"Nagpure BV, Bian JS (2015) Brain, learning, and memory: role of H2S in neurodegenerative diseases. Handb Exp Pharmacol 230:193\u2013215","journal-title":"Handb Exp Pharmacol"},{"issue":"7","key":"3684_CR172","doi-asserted-by":"publisher","first-page":"e22568","DOI":"10.1371\/journal.pone.0022568","volume":"6","author":"F Talaei","year":"2011","unstructured":"Talaei F, Bouma HR, Van der Graaf AC, Strijkstra AM, Schmidt M, Henning RH (2011) Serotonin and dopamine protect from hypothermia\/rewarming damage through the CBS\/H2S pathway. PLoS ONE 6(7):e22568","journal-title":"PLoS ONE"},{"issue":"8","key":"3684_CR173","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1515\/CCLM.2001.113","volume":"39","author":"D Fuchs","year":"2001","unstructured":"Fuchs D, Jaeger M, Widner B, Wirleitner B, Artner-Dworzak E, Leblhuber F (2001) Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake? Clin Chem Lab Med 39(8):691\u2013694","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"3684_CR174","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1006\/abbi.1997.0246","volume":"345","author":"SL Sunden","year":"1997","unstructured":"Sunden SL, Renduchintala MS, Park EI, Miklasz SD, Garrow TA (1997) Betaine-homocysteine methyltransferase expression in porcine and human tissues and chromosomal localization of the human gene. Arch Biochem Biophys 345(1):171\u2013174","journal-title":"Arch Biochem Biophys"},{"issue":"5","key":"3684_CR175","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","volume":"1","author":"JD Finkelstein","year":"1990","unstructured":"Finkelstein JD (1990) Methionine metabolism in mammals. J Nutr Biochem 1(5):228\u2013237","journal-title":"J Nutr Biochem"},{"issue":"2","key":"3684_CR176","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/S0021-9258(18)70493-6","volume":"230","author":"HH Tallan","year":"1958","unstructured":"Tallan HH, Moore S, Stein WH (1958) L-cystathionine in human brain. J Biol Chem 230(2):707\u2013716","journal-title":"J Biol Chem"},{"issue":"2","key":"3684_CR177","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1016\/j.neuint.2006.09.014","volume":"50","author":"L Diwakar","year":"2007","unstructured":"Diwakar L, Ravindranath V (2007) Inhibition of cystathionine-gamma-lyase leads to loss of glutathione and aggravation of mitochondrial dysfunction mediated by excitatory amino acid in the CNS. Neurochem Int 50(2):418\u2013426","journal-title":"Neurochem Int"},{"issue":"1","key":"3684_CR178","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1046\/j.1471-4159.2002.01097.x","volume":"83","author":"K Eto","year":"2002","unstructured":"Eto K, Kimura H (2002) The production of hydrogen sulfide is regulated by testosterone and S-adenosyl-L-methionine in mouse brain. J Neurochem 83(1):80\u201386","journal-title":"J Neurochem"},{"issue":"47","key":"3684_CR179","doi-asserted-by":"publisher","first-page":"35785","DOI":"10.1074\/jbc.M602799200","volume":"281","author":"V Vitvitsky","year":"2006","unstructured":"Vitvitsky V, Thomas M, Ghorpade A, Gendelman HE, Banerjee R (2006) A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem 281(47):35785\u201335793","journal-title":"J Biol Chem"},{"key":"3684_CR180","doi-asserted-by":"publisher","first-page":"7629673","DOI":"10.1155\/2019\/7629673","volume":"2019","author":"Q Yang","year":"2019","unstructured":"Yang Q, He GW (2019) Imbalance of homocysteine and H2S: significance, mechanisms, and therapeutic promise in vascular injury. Oxid Med Cell Longev 2019:7629673","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"3684_CR181","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1089\/ars.2010.3781","volume":"15","author":"O Kabil","year":"2011","unstructured":"Kabil O, Vitvitsky V, Xie P, Banerjee R (2011) The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues. Antioxid Redox Signal 15(2):363\u2013372","journal-title":"Antioxid Redox Signal"},{"issue":"11","key":"3684_CR182","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1089\/ars.2009.3074","volume":"13","author":"V Calabrese","year":"2010","unstructured":"Calabrese V, Cornelius C, Dinkova-Kostova AT, Calabrese EJ, Mattson MP (2010) Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders. Antioxid Redox Signal 13(11):1763\u20131811","journal-title":"Antioxid Redox Signal"},{"issue":"17","key":"3684_CR183","doi-asserted-by":"publisher","first-page":"11601","DOI":"10.1074\/jbc.M808026200","volume":"284","author":"T Chiku","year":"2009","unstructured":"Chiku T, Padovani D, Zhu W, Singh S, Vitvitsky V, Banerjee R (2009) H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem 284(17):11601\u201311612","journal-title":"J Biol Chem"},{"issue":"8","key":"3684_CR184","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1007\/s00109-015-1271-5","volume":"93","author":"S Nakano","year":"2015","unstructured":"Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T et al (2015) Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia\/reperfusion by limiting bioavailability of hydrogen sulfide anions. J Mol Med (Berl) 93(8):879\u2013889","journal-title":"J Mol Med (Berl)"},{"issue":"9","key":"3684_CR185","doi-asserted-by":"publisher","first-page":"654","DOI":"10.2174\/1871527317666180605072018","volume":"17","author":"M Kumar","year":"2018","unstructured":"Kumar M, Sandhir R (2018) Hydrogen sulfide in physiological and pathological mechanisms in brain. CNS Neurol Disord Drug Targets 17(9):654\u2013670","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"3","key":"3684_CR186","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1042\/BJ20110841","volume":"439","author":"Y Mikami","year":"2011","unstructured":"Mikami Y, Shibuya N, Kimura Y, Nagahara N, Ogasawara Y, Kimura H (2011) Thioredoxin and dihydrolipoic acid are required for 3-mercaptopyruvate sulfurtransferase to produce hydrogen sulfide. Biochem J 439(3):479\u2013485","journal-title":"Biochem J"},{"issue":"3","key":"3684_CR187","doi-asserted-by":"publisher","first-page":"388","DOI":"10.3390\/molecules22030388","volume":"22","author":"A Bilska-Wilkosz","year":"2017","unstructured":"Bilska-Wilkosz A, Iciek M, Kowalczyk-Pachel D, Gorny M, Sokolowska-Jezewicz M, Wlodek L (2017) Lipoic acid as a possible pharmacological source of hydrogen sulfide\/sulfane sulfur. Molecules 22(3):388","journal-title":"Molecules"},{"issue":"19","key":"3684_CR188","doi-asserted-by":"publisher","first-page":"6299","DOI":"10.1074\/jbc.RA120.012616","volume":"295","author":"PK Yadav","year":"2020","unstructured":"Yadav PK, Vitvitsky V, Carballal S, Seravalli J, Banerjee R (2020) Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations. J Biol Chem 295(19):6299\u20136311","journal-title":"J Biol Chem"},{"issue":"1","key":"3684_CR189","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1089\/ars.2008.2073","volume":"11","author":"N Tyagi","year":"2009","unstructured":"Tyagi N, Moshal KS, Sen U, Vacek TP, Kumar M, Hughes WM Jr, Kundu S, Tyagi SC (2009) H2S protects against methionine-induced oxidative stress in brain endothelial cells. Antioxid Redox Signal 11(1):25\u201333","journal-title":"Antioxid Redox Signal"},{"key":"3684_CR190","doi-asserted-by":"publisher","unstructured":"Sun H, Yang J, Shi Y, Wang Y, Li C, Zhu M (2020) Hydrogen sulfide in the nucleus tractus solitarii regulates gastric acid secretion in rats. J Physiol Pharmacol 71(4). https:\/\/doi.org\/10.26402\/jpp.2020.4.05","DOI":"10.26402\/jpp.2020.4.05"},{"issue":"7","key":"3684_CR191","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1080\/03007995.2022.2078097","volume":"38","author":"S Saberian","year":"2022","unstructured":"Saberian S, Rowan P, Hammes F, Patel P, Fernandez-Cortes F, Buesch K, Beitia Ortiz de Zarate I (2022) Burden of illness of aromatic L-amino acid decarboxylase deficiency: a survey of physicians in Southern Europe. Curr Med Res Opin 38(7):1115\u20131123","journal-title":"Curr Med Res Opin"},{"issue":"16","key":"3684_CR192","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1089\/ars.2017.7046","volume":"28","author":"A Untereiner","year":"2018","unstructured":"Untereiner A, Wu L (2018) Hydrogen sulfide and glucose homeostasis: a tale of sweet and the stink. Antioxid Redox Signal 28(16):1463\u20131482","journal-title":"Antioxid Redox Signal"},{"issue":"6","key":"3684_CR193","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1159\/000074887","volume":"78","author":"JC Umhau","year":"2003","unstructured":"Umhau JC, Petrulis SG, Diaz R, Rawlings R, George DT (2003) Blood glucose is correlated with cerebrospinal fluid neurotransmitter metabolites. Neuroendocrinology 78(6):339\u2013343","journal-title":"Neuroendocrinology"},{"issue":"8","key":"3684_CR194","doi-asserted-by":"publisher","first-page":"2804","DOI":"10.1096\/fj.09-143651","volume":"24","author":"NC Chen","year":"2010","unstructured":"Chen NC, Yang F, Capecci LM, Gu Z, Schafer AI, Durante W, Yang XF, Wang H (2010) Regulation of homocysteine metabolism and methylation in human and mouse tissues. FASEB J 24(8):2804\u20132817","journal-title":"FASEB J"},{"issue":"11","key":"3684_CR195","doi-asserted-by":"publisher","first-page":"2811","DOI":"10.1093\/jn\/131.11.2811","volume":"131","author":"MA Caudill","year":"2001","unstructured":"Caudill MA, Wang JC, Melnyk S, Pogribny IP, Jernigan S, Collins MD, Santos-Guzman J, Swendseid ME et al (2001) Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr 131(11):2811\u20132818","journal-title":"J Nutr"},{"issue":"1","key":"3684_CR196","first-page":"7","volume":"8","author":"AL Miller","year":"2003","unstructured":"Miller AL (2003) The methionine-homocysteine cycle and its effects on cognitive diseases. Altern Med Rev 8(1):7\u201319","journal-title":"Altern Med Rev"},{"key":"3684_CR197","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.jchromb.2019.06.032","volume":"1124","author":"AV Ivanov","year":"2019","unstructured":"Ivanov AV, Dubchenko EA, Kruglova MP, Virus ED, Bulgakova PO, Alexandrin VV, Fedoseev AN, Boyko AN et al (2019) Determination of S-adenosylmethionine and S-adenosylhomocysteine in blood plasma by UPLC with fluorescence detection. J Chromatogr B Analyt Technol Biomed Life Sci 1124:366\u2013374","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"7","key":"3684_CR198","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1136\/jnnp.53.7.569","volume":"53","author":"R Surtees","year":"1990","unstructured":"Surtees R, Hyland K (1990) L-3,4-dihydroxyphenylalanine (levodopa) lowers central nervous system S-adenosylmethionine concentrations in humans. J Neurol Neurosurg Psychiatry 53(7):569\u2013572","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"3684_CR199","doi-asserted-by":"publisher","first-page":"927","DOI":"10.3390\/ijms22020927","volume":"22","author":"H Nieraad","year":"2021","unstructured":"Nieraad H, de Bruin N, Arne O, Hofmann MCJ, Gurke R, Schmidt D, Ritter M, Parnham MJ et al (2021) Effects of Alzheimer-like pathology on homocysteine and homocysteic acid levels-an exploratory in vivo kinetic study. Int J Mol Sci 22(2):927","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3684_CR200","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1016\/0361-9230(87)90077-3","volume":"19","author":"JW Olney","year":"1987","unstructured":"Olney JW, Price MT, Salles KS, Labruyere J, Ryerson R, Mahan K, Frierdich G, Samson L (1987) L-homocysteic acid: an endogenous excitotoxic ligand of the NMDA receptor. Brain Res Bull 19(5):597\u2013602","journal-title":"Brain Res Bull"},{"issue":"3","key":"3684_CR201","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1021\/pr034115o","volume":"3","author":"S Sommer","year":"2004","unstructured":"Sommer S, Hunzinger C, Schillo S, Klemm M, Biefang-Arndt K, Schwall G, Putter S, Hoelzer K et al (2004) Molecular analysis of homocysteic acid-induced neuronal stress. J Proteome Res 3(3):572\u2013581","journal-title":"J Proteome Res"},{"issue":"1\u20132","key":"3684_CR202","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.jns.2003.11.009","volume":"218","author":"P Gortz","year":"2004","unstructured":"Gortz P, Hoinkes A, Fleischer W, Otto F, Schwahn B, Wendel U, Siebler M (2004) Implications for hyperhomocysteinemia: not homocysteine but its oxidized forms strongly inhibit neuronal network activity. J Neurol Sci 218(1\u20132):109\u2013114","journal-title":"J Neurol Sci"},{"issue":"1","key":"3684_CR203","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1006\/exnr.1999.7264","volume":"161","author":"J Folbergrova","year":"2000","unstructured":"Folbergrova J, Haugvicova R, Mares P (2000) Behavioral and metabolic changes in immature rats during seizures induced by homocysteic acid: the protective effect of NMDA and non-NMDA receptor antagonists. Exp Neurol 161(1):336\u2013345","journal-title":"Exp Neurol"},{"issue":"1","key":"3684_CR204","doi-asserted-by":"publisher","first-page":"e8593","DOI":"10.1371\/journal.pone.0008593","volume":"5","author":"T Hasegawa","year":"2010","unstructured":"Hasegawa T, Mikoda N, Kitazawa M, LaFerla FM (2010) Treatment of Alzheimer\u2019s disease with anti-homocysteic acid antibody in 3xTg-AD male mice. PLoS ONE 5(1):e8593","journal-title":"PLoS ONE"},{"issue":"9","key":"3684_CR205","doi-asserted-by":"publisher","first-page":"1838","DOI":"10.18632\/aging.101046","volume":"8","author":"T Hasegawa","year":"2016","unstructured":"Hasegawa T, Ukai W (2016) Targeting therapy for homocysteic acid in the blood represents a potential recovery treatment for cognition in Alzheimer\u2019s disease patients. Aging (Albany NY) 8(9):1838\u20131843","journal-title":"Aging (Albany NY)"},{"issue":"2","key":"3684_CR206","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1093\/brain\/awy331","volume":"142","author":"K Kojima","year":"2019","unstructured":"Kojima K, Nakajima T, Taga N, Miyauchi A, Kato M, Matsumoto A, Ikeda T, Nakamura K et al (2019) Gene therapy improves motor and mental function of aromatic l-amino acid decarboxylase deficiency. Brain 142(2):322\u2013333","journal-title":"Brain"},{"issue":"8","key":"3684_CR207","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1007\/s00702-003-0004-z","volume":"110","author":"F Blandini","year":"2003","unstructured":"Blandini F, Nappi G, Fancellu R, Mangiagalli A, Samuele A, Riboldazzi G, Calandrella D, Pacchetti C et al (2003) Modifications of plasma and platelet levels of L-DOPA and its direct metabolites during treatment with tolcapone or entacapone in patients with Parkinson\u2019s disease. J Neural Transm (Vienna) 110(8):911\u2013922","journal-title":"J Neural Transm (Vienna)"},{"issue":"10","key":"3684_CR208","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1007\/s00702-009-0275-0","volume":"116","author":"T Muller","year":"2009","unstructured":"Muller T, Muhlack S (2009) Peripheral COMT inhibition prevents levodopa associated homocysteine increase. J Neural Transm (Vienna) 116(10):1253\u20131256","journal-title":"J Neural Transm (Vienna)"},{"issue":"8","key":"3684_CR209","doi-asserted-by":"publisher","first-page":"e11951","DOI":"10.1371\/journal.pone.0011951","volume":"5","author":"KS Kang","year":"2010","unstructured":"Kang KS, Wen Y, Yamabe N, Fukui M, Bishop SC, Zhu BT (2010) Dual beneficial effects of (-)-epigallocatechin-3-gallate on levodopa methylation and hippocampal neurodegeneration: in vitro and in vivo studies. PLoS ONE 5(8):e11951","journal-title":"PLoS ONE"},{"key":"3684_CR210","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2012.11.043","volume":"1497","author":"KS Kang","year":"2013","unstructured":"Kang KS, Yamabe N, Wen Y, Fukui M, Zhu BT (2013) Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration. Brain Res 1497:1\u201314","journal-title":"Brain Res"},{"issue":"1","key":"3684_CR211","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1007\/s12031-010-9477-z","volume":"45","author":"XQ Tang","year":"2011","unstructured":"Tang XQ, Shen XT, Huang YE, Chen RQ, Ren YK, Fang HR, Zhuang YY, Wang CY (2011) Inhibition of endogenous hydrogen sulfide generation is associated with homocysteine-induced neurotoxicity: role of ERK1\/2 activation. J Mol Neurosci 45(1):60\u201367","journal-title":"J Mol Neurosci"},{"issue":"50","key":"3684_CR212","doi-asserted-by":"publisher","first-page":"52082","DOI":"10.1074\/jbc.C400481200","volume":"279","author":"X Chen","year":"2004","unstructured":"Chen X, Jhee KH, Kruger WD (2004) Production of the neuromodulator H2S by cystathionine beta-synthase via the condensation of cysteine and homocysteine. J Biol Chem 279(50):52082\u201352086","journal-title":"J Biol Chem"},{"issue":"1","key":"3684_CR213","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2119\/molmed.2015.00035","volume":"21","author":"C Coletta","year":"2015","unstructured":"Coletta C, Modis K, Szczesny B, Brunyanszki A, Olah G, Rios EC, Yanagi K, Ahmad A et al (2015) Regulation of vascular tone, angiogenesis and cellular bioenergetics by the 3-mercaptopyruvate sulfurtransferase\/H2S pathway: functional impairment by hyperglycemia and restoration by DL-alpha-lipoic acid. Mol Med 21(1):1\u201314","journal-title":"Mol Med"},{"issue":"2","key":"3684_CR214","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0006-8993(99)02372-0","volume":"855","author":"B Lockhart","year":"2000","unstructured":"Lockhart B, Jones C, Cuisinier C, Villain N, Peyroulan D, Lestage P (2000) Inhibition of L-homocysteic acid and buthionine sulphoximine-mediated neurotoxicity in rat embryonic neuronal cultures with alpha-lipoic acid enantiomers. Brain Res 855(2):292\u2013297","journal-title":"Brain Res"},{"issue":"1","key":"3684_CR215","first-page":"1118","volume":"17","author":"SF Zhang","year":"2018","unstructured":"Zhang SF, Xie CL, Lin JY, Wang MH, Wang XJ, Liu ZG (2018) Lipoic acid alleviates LDOPAinduced dyskinesia in 6OHDA parkinsonian rats via antioxidative stress. Mol Med Rep 17(1):1118\u20131124","journal-title":"Mol Med Rep"},{"issue":"4","key":"3684_CR216","doi-asserted-by":"crossref","first-page":"375","DOI":"10.55782\/ane-2021-037","volume":"81","author":"J Mao","year":"2021","unstructured":"Mao J, Gao H, Bai W, Zeng H, Ren Y, Liu Y, Yang X (2021) Lipoic acid alleviates LPS-evoked PC12 cell damage by targeting p53 and inactivating the NF-kappaB pathway. Acta Neurobiol Exp (Wars) 81(4):375\u2013385","journal-title":"Acta Neurobiol Exp (Wars)"},{"issue":"1\u20133","key":"3684_CR217","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/BF01345261","volume":"14","author":"PF VonVoigtlander","year":"1998","unstructured":"VonVoigtlander PF, Fici GJ, Althaus JS (1998) Pharmacological approaches to counter the toxicity of Dopa. Amino Acids 14(1\u20133):189\u2013196","journal-title":"Amino Acids"},{"issue":"1\u20132","key":"3684_CR218","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/S0006-8993(96)01056-6","volume":"743","author":"N Cheng","year":"1996","unstructured":"Cheng N, Maeda T, Kume T, Kaneko S, Kochiyama H, Akaike A, Goshima Y, Misu Y (1996) Differential neurotoxicity induced by L-DOPA and dopamine in cultured striatal neurons. Brain Res 743(1\u20132):278\u2013283","journal-title":"Brain Res"},{"issue":"1","key":"3684_CR219","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s11011-011-9232-3","volume":"26","author":"FR Machado","year":"2011","unstructured":"Machado FR, Ferreira AG, da Cunha AA, Tagliari B, Mussulini BH, Wofchuk S, Wyse AT (2011) Homocysteine alters glutamate uptake and Na+, K+-ATPase activity and oxidative status in rats hippocampus: protection by vitamin C. Metab Brain Dis 26(1):61\u201367","journal-title":"Metab Brain Dis"},{"issue":"5","key":"3684_CR220","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.1111\/j.1471-4159.2006.04000.x","volume":"98","author":"S Khanna","year":"2006","unstructured":"Khanna S, Roy S, Parinandi NL, Maurer M, Sen CK (2006) Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem 98(5):1474\u20131486","journal-title":"J Neurochem"},{"issue":"Suppl","key":"3684_CR221","doi-asserted-by":"publisher","first-page":"S128","DOI":"10.1002\/ana.410320722","volume":"32","author":"S Fahn","year":"1992","unstructured":"Fahn S (1992) A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson\u2019s disease. Ann Neurol 32(Suppl):S128\u2013S132","journal-title":"Ann Neurol"},{"issue":"Pt B","key":"3684_CR222","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.arr.2015.07.008","volume":"24","author":"AM Kubis","year":"2015","unstructured":"Kubis AM, Piwowar A (2015) The new insight on the regulatory role of the vitamin D3 in metabolic pathways characteristic for cancerogenesis and neurodegenerative diseases. Ageing Res Rev 24(Pt B):126\u2013137","journal-title":"Ageing Res Rev"},{"issue":"1","key":"3684_CR223","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1186\/s12974-018-1266-6","volume":"15","author":"LAR Lima","year":"2018","unstructured":"Lima LAR, Lopes MJP, Costa RO, Lima FAV, Neves KRT, Calou IBF, Andrade GM, Viana GSB (2018) Vitamin D protects dopaminergic neurons against neuroinflammation and oxidative stress in hemiparkinsonian rats. J Neuroinflammation 15(1):249","journal-title":"J Neuroinflammation"},{"key":"3684_CR224","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/bs.vh.2015.10.007","volume":"100","author":"RP Orme","year":"2016","unstructured":"Orme RP, Middleditch C, Waite L, Fricker RA (2016) The role of vitamin D(3) in the development and neuroprotection of midbrain dopamine neurons. Vitam Horm 100:273\u2013297","journal-title":"Vitam Horm"},{"issue":"5","key":"3684_CR225","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.3945\/ajcn.112.051664","volume":"97","author":"M Suzuki","year":"2013","unstructured":"Suzuki M, Yoshioka M, Hashimoto M, Murakami M, Noya M, Takahashi D, Urashima M (2013) Randomized, double-blind, placebo-controlled trial of vitamin D supplementation in Parkinson disease. Am J Clin Nutr 97(5):1004\u20131013","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"3684_CR226","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/j.neuro.2011.05.009","volume":"32","author":"KH Park","year":"2011","unstructured":"Park KH, Choi NY, Koh SH, Park HH, Kim YS, Kim MJ, Lee SJ, Yu HJ et al (2011) L-DOPA neurotoxicity is prevented by neuroprotective effects of erythropoietin. Neurotoxicology 32(6):879\u2013887","journal-title":"Neurotoxicology"},{"issue":"2","key":"3684_CR227","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0304-3940(00)01441-5","volume":"292","author":"M Yamamoto","year":"2000","unstructured":"Yamamoto M, Koshimura K, Kawaguchi M, Sohmiya M, Murakami Y, Kato Y (2000) Stimulating effect of erythropoietin on the release of dopamine and acetylcholine from the rat brain slice. Neurosci Lett 292(2):131\u2013133","journal-title":"Neurosci Lett"},{"key":"3684_CR228","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.bbr.2015.08.011","volume":"294","author":"CK Huang","year":"2015","unstructured":"Huang CK, Chang YT, Amstislavskaya TG, Tikhonova MA, Lin CL, Hung CS, Lai TJ, Ho YJ (2015) Synergistic effects of ceftriaxone and erythropoietin on neuronal and behavioral deficits in an MPTP-induced animal model of Parkinson\u2019s disease dementia. Behav Brain Res 294:198\u2013207","journal-title":"Behav Brain Res"},{"issue":"2","key":"3684_CR229","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1111\/j.1474-9726.2009.00543.x","volume":"9","author":"LF Hu","year":"2010","unstructured":"Hu LF, Lu M, Tiong CX, Dawe GS, Hu G, Bian JS (2010) Neuroprotective effects of hydrogen sulfide on Parkinson\u2019s disease rat models. Aging Cell 9(2):135\u2013146","journal-title":"Aging Cell"},{"issue":"2","key":"3684_CR230","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1089\/ars.2010.3671","volume":"15","author":"K Kida","year":"2011","unstructured":"Kida K, Yamada M, Tokuda K, Marutani E, Kakinohana M, Kaneki M, Ichinose F (2011) Inhaled hydrogen sulfide prevents neurodegeneration and movement disorder in a mouse model of Parkinson\u2019s disease. Antioxid Redox Signal 15(2):343\u2013352","journal-title":"Antioxid Redox Signal"},{"issue":"1","key":"3684_CR231","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/15287399009531436","volume":"31","author":"LJ Hayden","year":"1990","unstructured":"Hayden LJ, Goeden H, Roth SH (1990) Exposure to low levels of hydrogen sulfide elevates circulating glucose in maternal rats. J Toxicol Environ Health 31(1):45\u201352","journal-title":"J Toxicol Environ Health"},{"issue":"15","key":"3684_CR232","doi-asserted-by":"publisher","first-page":"1906","DOI":"10.1089\/ars.2012.4645","volume":"18","author":"G Yang","year":"2013","unstructured":"Yang G, Zhao K, Ju Y, Mani S, Cao Q, Puukila S, Khaper N, Wu L et al (2013) Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. Antioxid Redox Signal 18(15):1906\u20131919","journal-title":"Antioxid Redox Signal"},{"key":"3684_CR233","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1038\/ncomms2623","volume":"4","author":"MS Vandiver","year":"2013","unstructured":"Vandiver MS, Paul BD, Xu R, Karuppagounder S, Rao F, Snowman AM, Ko HS, Lee YI et al (2013) Sulfhydration mediates neuroprotective actions of parkin. Nat Commun 4:1626","journal-title":"Nat Commun"},{"issue":"3","key":"3684_CR234","doi-asserted-by":"publisher","first-page":"652","DOI":"10.3390\/antiox12030652","volume":"12","author":"L Zhou","year":"2023","unstructured":"Zhou L, Wang Q (2023) Advances of H(2)S in regulating neurodegenerative diseases by preserving mitochondria function. Antioxidants (Basel) 12(3):652","journal-title":"Antioxidants (Basel)"},{"issue":"5","key":"3684_CR235","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.neuint.2013.09.003","volume":"63","author":"H Kimura","year":"2013","unstructured":"Kimura H (2013) Physiological role of hydrogen sulfide and polysulfide in the central nervous system. Neurochem Int 63(5):492\u2013497","journal-title":"Neurochem Int"},{"key":"3684_CR236","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1146\/annurev-genom-082410-101440","volume":"12","author":"I Martin","year":"2011","unstructured":"Martin I, Dawson VL, Dawson TM (2011) Recent advances in the genetics of Parkinson\u2019s disease. Annu Rev Genomics Hum Genet 12:301\u2013325","journal-title":"Annu Rev Genomics Hum Genet"},{"issue":"4","key":"3684_CR237","doi-asserted-by":"publisher","first-page":"1515","DOI":"10.1152\/physrev.00047.2011","volume":"92","author":"SC Lu","year":"2012","unstructured":"Lu SC, Mato JM (2012) S-adenosylmethionine in liver health, injury, and cancer. Physiol Rev 92(4):1515\u20131542","journal-title":"Physiol Rev"},{"issue":"6","key":"3684_CR238","doi-asserted-by":"publisher","first-page":"1225","DOI":"10.1002\/1531-8257(200011)15:6<1225::AID-MDS1025>3.0.CO;2-A","volume":"15","author":"A Di Rocco","year":"2000","unstructured":"Di Rocco A, Rogers JD, Brown R, Werner P, Bottiglieri T (2000) S-adenosyl-methionine improves depression in patients with Parkinson\u2019s disease in an open-label clinical trial. Mov Disord 15(6):1225\u20131229","journal-title":"Mov Disord"},{"issue":"2","key":"3684_CR239","first-page":"63","volume":"12","author":"S Bostantjopoulou","year":"1997","unstructured":"Bostantjopoulou S, Kyriazis G, Katsarou Z, Kiosseoglou G, Kazis A, Mentenopoulos G (1997) Superoxide dismutase activity in early and advanced Parkinson\u2019s disease. Funct Neurol 12(2):63\u201368","journal-title":"Funct Neurol"},{"issue":"3","key":"3684_CR240","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/0304-3940(86)90320-4","volume":"67","author":"TL Perry","year":"1986","unstructured":"Perry TL, Yong VW (1986) Idiopathic Parkinson\u2019s disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci Lett 67(3):269\u2013274","journal-title":"Neurosci Lett"},{"issue":"32","key":"3684_CR241","doi-asserted-by":"publisher","first-page":"29194","DOI":"10.1074\/jbc.M500984200","volume":"280","author":"J Peng","year":"2005","unstructured":"Peng J, Stevenson FF, Doctrow SR, Andersen JK (2005) Superoxide dismutase\/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J Biol Chem 280(32):29194\u201329198","journal-title":"J Biol Chem"},{"issue":"16","key":"3684_CR242","doi-asserted-by":"publisher","first-page":"8689","DOI":"10.3390\/ijms22168689","volume":"22","author":"M Asanuma","year":"2021","unstructured":"Asanuma M, Miyazaki I (2021) Glutathione and related molecules in parkinsonism. Int J Mol Sci 22(16):8689","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3684_CR243","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/S0022-510X(99)00192-6","volume":"170","author":"Y Ihara","year":"1999","unstructured":"Ihara Y, Chuda M, Kuroda S, Hayabara T (1999) Hydroxyl radical and superoxide dismutase in blood of patients with Parkinson\u2019s disease: relationship to clinical data. J Neurol Sci 170(2):90\u201395","journal-title":"J Neurol Sci"},{"issue":"5","key":"3684_CR244","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0892-0362(02)00221-0","volume":"24","author":"W Maruyama","year":"2002","unstructured":"Maruyama W, Akao Y, Carrillo MC, Kitani K, Youdium MB, Naoi M (2002) Neuroprotection by propargylamines in Parkinson\u2019s disease: suppression of apoptosis and induction of prosurvival genes. Neurotoxicol Teratol 24(5):675\u2013682","journal-title":"Neurotoxicol Teratol"},{"issue":"1","key":"3684_CR245","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1038\/s41467-020-14788-x","volume":"11","author":"Y Wei","year":"2020","unstructured":"Wei Y, Lu M, Mei M, Wang H, Han Z, Chen M, Yao H, Song N et al (2020) Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. Nat Commun 11(1):941","journal-title":"Nat Commun"},{"key":"3684_CR246","doi-asserted-by":"publisher","first-page":"136669","DOI":"10.1016\/j.neulet.2022.136669","volume":"781","author":"J Zhang","year":"2022","unstructured":"Zhang J, Wang M, Zhao Y, Zhang Y, Gao Y, Zhang X, Yang G (2022) Alpha-lipoic acid improved motor function in MPTP-induced Parkinsonian mice by reducing neuroinflammation in the nigral and spinal cord. Neurosci Lett 781:136669","journal-title":"Neurosci Lett"},{"issue":"20","key":"3684_CR247","doi-asserted-by":"publisher","first-page":"7522","DOI":"10.1074\/jbc.TM117.000259","volume":"293","author":"A Solmonson","year":"2018","unstructured":"Solmonson A, DeBerardinis RJ (2018) Lipoic acid metabolism and mitochondrial redox regulation. J Biol Chem 293(20):7522\u20137530","journal-title":"J Biol Chem"},{"key":"3684_CR248","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1196\/annals.1369.030","volume":"1074","author":"GT Vatassery","year":"2006","unstructured":"Vatassery GT, Smith WE, Quach HT (2006) Effect of oxidative stress induced by L-dopa on endogenous antioxidants in PC-12 cells. Ann N Y Acad Sci 1074:330\u2013336","journal-title":"Ann N Y Acad Sci"},{"issue":"6","key":"3684_CR249","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/S0197-0186(96)00029-0","volume":"29","author":"SK Han","year":"1996","unstructured":"Han SK, Cohen G (1996) Inhibition of catalase in mesencephalic cultures by L-DOPA and dopamine. Neurochem Int 29(6):645\u2013649","journal-title":"Neurochem Int"},{"issue":"10","key":"3684_CR250","doi-asserted-by":"publisher","first-page":"1542","DOI":"10.1016\/j.freeradbiomed.2010.08.016","volume":"49","author":"Y Saito","year":"2010","unstructured":"Saito Y, Nishio K, Akazawa YO, Yamanaka K, Miyama A, Yoshida Y, Noguchi N, Niki E (2010) Cytoprotective effects of vitamin E homologues against glutamate-induced cell death in immature primary cortical neuron cultures: tocopherols and tocotrienols exert similar effects by antioxidant function. Free Radic Biol Med 49(10):1542\u20131549","journal-title":"Free Radic Biol Med"},{"issue":"1","key":"3684_CR251","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1001\/jama.2013.282834","volume":"311","author":"MW Dysken","year":"2014","unstructured":"Dysken MW, Sano M, Asthana S, Vertrees JE, Pallaki M, Llorente M, Love S, Schellenberg GD et al (2014) Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA 311(1):33\u201344","journal-title":"JAMA"},{"issue":"8","key":"3684_CR252","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1002\/mds.25405","volume":"28","author":"AL Peterson","year":"2013","unstructured":"Peterson AL, Mancini M, Horak FB (2013) The relationship between balance control and vitamin D in Parkinson\u2019s disease-a pilot study. Mov Disord 28(8):1133\u20131137","journal-title":"Mov Disord"},{"issue":"3","key":"3684_CR253","first-page":"E266","volume":"244","author":"M Gascon-Barre","year":"1983","unstructured":"Gascon-Barre M, Huet PM (1983) Apparent [3H]1,25-dihydroxyvitamin D3 uptake by canine and rodent brain. Am J Physiol 244(3):E266\u2013E271","journal-title":"Am J Physiol"},{"issue":"1","key":"3684_CR254","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1152\/physrev.00014.2015","volume":"96","author":"S Christakos","year":"2016","unstructured":"Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G (2016) Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev 96(1):365\u2013408","journal-title":"Physiol Rev"},{"issue":"5","key":"3684_CR255","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1093\/oxfordjournals.jbchem.a022662","volume":"127","author":"S Kato","year":"2000","unstructured":"Kato S (2000) The function of vitamin D receptor in vitamin D action. J Biochem 127(5):717\u2013722","journal-title":"J Biochem"},{"issue":"1","key":"3684_CR256","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","volume":"29","author":"DW Eyles","year":"2005","unstructured":"Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ (2005) Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. J Chem Neuroanat 29(1):21\u201330","journal-title":"J Chem Neuroanat"},{"issue":"1","key":"3684_CR257","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1038\/s41467-020-15041-1","volume":"11","author":"D Wakhloo","year":"2020","unstructured":"Wakhloo D, Scharkowski F, Curto Y, Javed Butt U, Bansal V, Steixner-Kumar AA, Wustefeld L, Rajput A et al (2020) Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin. Nat Commun 11(1):1313","journal-title":"Nat Commun"},{"issue":"1","key":"3684_CR258","first-page":"49","volume":"23","author":"M Garcia-Llano","year":"2021","unstructured":"Garcia-Llano M, Pedroso-Ibanez I, Morales-Chacon L, Rodriguez-Obaya T, Perez-Ruiz L, Sosa-Teste I, Amaro-Gonzalez D, Bringas-Vega ML (2021) Short-term tolerance of nasally-administered NeuroEPO in patients with Parkinson disease. MEDICC Rev 23(1):49\u201354","journal-title":"MEDICC Rev"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03684-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03684-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03684-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T21:44:11Z","timestamp":1730497451000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03684-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,13]]},"references-count":258,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["3684"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03684-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,13]]},"assertion":[{"value":"7 February 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 September 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is an observational study. The University at Buffalo Research Ethics Committee has confirmed that no ethical approval is required.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"NA.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"NA.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The author declares no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}