{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:40:21Z","timestamp":1794008421814,"version":"4.8.0"},"reference-count":77,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R56 NS127924"],"award-info":[{"award-number":["R56 NS127924"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000065","name":"NINDS","doi-asserted-by":"crossref","award":["R01-NS097800"],"award-info":[{"award-number":["R01-NS097800"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"crossref"}]},{"name":"NIH","award":["DK117183"],"award-info":[{"award-number":["DK117183"]}]},{"name":"NIH","award":["DK132230"],"award-info":[{"award-number":["DK132230"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1007\/s12035-023-03739-4","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T23:02:46Z","timestamp":1699570966000},"page":"2822-2838","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Intranasal Delivery of Mitochondria Attenuates Brain Injury by AMPK and SIRT1\/PGC-1\u03b1 Pathways in a Murine Model of Photothrombotic Stroke"],"prefix":"10.1007","volume":"61","author":[{"given":"Mohd.","family":"Salman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda S","family":"Stayton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehkashan","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshi","family":"Parveen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle A","family":"Puchowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhel","family":"Parvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandeep","family":"Bajwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tauheed","family":"Ishrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"3739_CR1","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1016\/S1474-4422(21)00252-0","volume":"20","author":"VL Feigin","year":"2021","unstructured":"Feigin VL, Stark BA, Johnson CO et al (2021) Global, regional, and national burden of stroke and its risk factors, 1990\u20132019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Neurol 20:795\u2013820. https:\/\/doi.org\/10.1016\/S1474-4422(21)00252-0","journal-title":"Lancet Neurol"},{"key":"3739_CR2","doi-asserted-by":"publisher","first-page":"105138","DOI":"10.1016\/j.neuint.2021.105138","volume":"149","author":"P Kaushik","year":"2021","unstructured":"Kaushik P, Ali M, Salman M et al (2021) Harnessing the mitochondrial integrity for neuroprotection: therapeutic role of piperine against experimental ischemic stroke. Neurochem Int 149:105138. https:\/\/doi.org\/10.1016\/j.neuint.2021.105138","journal-title":"Neurochem Int"},{"key":"3739_CR3","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1177\/1941874415583116","volume":"5","author":"NT Cheng","year":"2015","unstructured":"Cheng NT, Kim AS (2015) Intravenous thrombolysis for acute ischemic stroke within 3 hours versus between 3 and 4.5 hours of symptom onset. Neurohospitalist 5:101\u2013109. https:\/\/doi.org\/10.1177\/1941874415583116","journal-title":"Neurohospitalist"},{"key":"3739_CR4","doi-asserted-by":"publisher","unstructured":"Papanagiotou P, Ntaios G (2018) Endovascular thrombectomy in acute ischemic stroke. Circ Cardiovasc Interv 11. https:\/\/doi.org\/10.1161\/CIRCINTERVENTIONS.117.005362","DOI":"10.1161\/CIRCINTERVENTIONS.117.005362"},{"key":"3739_CR5","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.2174\/1570159X16666180302115544","volume":"16","author":"E Sekerdag","year":"2018","unstructured":"Sekerdag E, Solaroglu I, Gursoy-Ozdemir Y (2018) Cell death mechanisms in stroke and novel molecular and cellular treatment options. Curr Neuropharmacol 16:1396\u20131415. https:\/\/doi.org\/10.2174\/1570159X16666180302115544","journal-title":"Curr Neuropharmacol"},{"key":"3739_CR6","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1038\/s41392-022-01064-1","volume":"7","author":"C Qin","year":"2022","unstructured":"Qin C, Yang S, Chu Y-H et al (2022) Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions. Signal Transduct Target Ther 7:215. https:\/\/doi.org\/10.1038\/s41392-022-01064-1","journal-title":"Signal Transduct Target Ther"},{"key":"3739_CR7","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4103\/bc.bc_14_18","volume":"4","author":"E Russo","year":"2018","unstructured":"Russo E, Nguyen H, Lippert T et al (2018) Mitochondrial targeting as a novel therapy for stroke. Brain Circ 4:84. https:\/\/doi.org\/10.4103\/bc.bc_14_18","journal-title":"Brain Circ"},{"key":"3739_CR8","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.freeradbiomed.2019.11.005","volume":"146","author":"Z He","year":"2020","unstructured":"He Z, Ning N, Zhou Q et al (2020) Mitochondria as a therapeutic target for ischemic stroke. Free Radic Biol Med 146:45\u201358. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2019.11.005","journal-title":"Free Radic Biol Med"},{"key":"3739_CR9","doi-asserted-by":"publisher","first-page":"169","DOI":"10.3390\/biomedicines9020169","volume":"9","author":"M Carinci","year":"2021","unstructured":"Carinci M, Vezzani B, Patergnani S et al (2021) Different roles of mitochondria in cell death and inflammation: focusing on mitochondrial quality control in ischemic stroke and reperfusion. Biomedicines 9:169. https:\/\/doi.org\/10.3390\/biomedicines9020169","journal-title":"Biomedicines"},{"key":"3739_CR10","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1111\/j.1471-4159.2009.05897.x","volume":"109","author":"K Niizuma","year":"2009","unstructured":"Niizuma K, Endo H, Chan PH (2009) Oxidative stress and mitochondrial dysfunction as determinants of ischemic neuronal death and survival. J Neurochem 109:133\u2013138. https:\/\/doi.org\/10.1111\/j.1471-4159.2009.05897.x","journal-title":"J Neurochem"},{"key":"3739_CR11","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.jns.2012.06.004","volume":"322","author":"D Z\u00e1dori","year":"2012","unstructured":"Z\u00e1dori D, Kliv\u00e9nyi P, Szal\u00e1rdy L et al (2012) Mitochondrial disturbances, excitotoxicity, neuroinflammation and kynurenines: novel therapeutic strategies for neurodegenerative disorders. J Neurol Sci 322:187\u2013191. https:\/\/doi.org\/10.1016\/j.jns.2012.06.004","journal-title":"J Neurol Sci"},{"key":"3739_CR12","doi-asserted-by":"publisher","first-page":"7199","DOI":"10.3390\/ijms12107199","volume":"12","author":"S-D Chen","year":"2011","unstructured":"Chen S-D, Yang D-I, Lin T-K et al (2011) Roles of oxidative stress, apoptosis, PGC-1\u03b1 and mitochondrial biogenesis in cerebral ischemia. Int J Mol Sci 12:7199\u20137215. https:\/\/doi.org\/10.3390\/ijms12107199","journal-title":"Int J Mol Sci"},{"key":"3739_CR13","doi-asserted-by":"publisher","first-page":"3110","DOI":"10.1007\/s12035-022-02795-6","volume":"59","author":"M Song","year":"2022","unstructured":"Song M, Zhou Y, Fan X (2022) Mitochondrial quality and quantity control: mitophagy is a potential therapeutic target for ischemic stroke. Mol Neurobiol 59:3110\u20133123. https:\/\/doi.org\/10.1007\/s12035-022-02795-6","journal-title":"Mol Neurobiol"},{"key":"3739_CR14","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.freeradbiomed.2009.12.022","volume":"48","author":"ML Circu","year":"2010","unstructured":"Circu ML, Aw TY (2010) Reactive oxygen species, cellular redox systems, and apoptosis. Free Radic Biol Med 48:749\u2013762. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2009.12.022","journal-title":"Free Radic Biol Med"},{"key":"3739_CR15","doi-asserted-by":"publisher","first-page":"20558","DOI":"10.1038\/s41598-021-00071-6","volume":"11","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Liu X, Zheng Y et al (2021) Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK\/SIRT-1\/NF-\u03baB signaling pathway and gut microbiota. Sci Rep 11:20558. https:\/\/doi.org\/10.1038\/s41598-021-00071-6","journal-title":"Sci Rep"},{"key":"3739_CR16","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1007\/s11011-021-00750-3","volume":"36","author":"MM Gravandi","year":"2021","unstructured":"Gravandi MM, Fakhri S, Zarneshan SN et al (2021) Flavonoids modulate AMPK\/PGC-1\u03b1 and interconnected pathways toward potential neuroprotective activities. Metab Brain Dis 36:1501\u20131521. https:\/\/doi.org\/10.1007\/s11011-021-00750-3","journal-title":"Metab Brain Dis"},{"issue":"5","key":"3739_CR17","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/j.cmet.2012.04.003","volume":"15","author":"NL Price","year":"2012","unstructured":"Price NL, Gomes AP, Ling AJ, Duarte FV, Martin-Montalvo A, North BJ, Agarwal B, Ye L et al (2012) SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab 15(5):675\u2013690. https:\/\/doi.org\/10.1016\/j.cmet.2012.04.003","journal-title":"Cell Metab"},{"key":"3739_CR18","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1038\/nature07813","volume":"458","author":"C Cant\u00f3","year":"2009","unstructured":"Cant\u00f3 C, Gerhart-Hines Z, Feige JN et al (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT-1 activity. Nature 458:1056\u20131060. https:\/\/doi.org\/10.1038\/nature07813","journal-title":"Nature"},{"key":"3739_CR19","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1210\/er.2002-0012","volume":"24","author":"P Puigserver","year":"2003","unstructured":"Puigserver P, Spiegelman BM (2003) Peroxisome proliferator-activated receptor-\u03b3 coactivator 1\u03b1 (PGC-1\u03b1): transcriptional coactivator and metabolic regulator. Endocr Rev 24:78\u201390. https:\/\/doi.org\/10.1210\/er.2002-0012","journal-title":"Endocr Rev"},{"key":"3739_CR20","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00246-011-9889-8","volume":"32","author":"JG Duncan","year":"2011","unstructured":"Duncan JG (2011) Peroxisome proliferator activated receptor-alpha (PPAR\u03b1) and PPAR gamma coactivator-1alpha (PGC-1\u03b1) regulation of cardiac metabolism in diabetes. Pediatr Cardiol 32:323\u2013328. https:\/\/doi.org\/10.1007\/s00246-011-9889-8","journal-title":"Pediatr Cardiol"},{"key":"3739_CR21","doi-asserted-by":"publisher","first-page":"7132","DOI":"10.1007\/s12035-018-0882-6","volume":"55","author":"GP Selvakumar","year":"2018","unstructured":"Selvakumar GP, Iyer SS, Kempuraj D et al (2018) Glia maturation factor dependent inhibition of mitochondrial PGC-1\u03b1 triggers oxidative stress-mediated apoptosis in N27 rat dopaminergic neuronal cells. Mol Neurobiol 55:7132\u20137152. https:\/\/doi.org\/10.1007\/s12035-018-0882-6","journal-title":"Mol Neurobiol"},{"key":"3739_CR22","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1096\/fasebj.11.4.9068609","volume":"11","author":"CN Falany","year":"1997","unstructured":"Falany CN (1997) Enzymology of human cytosolic sulfotransferases. FASEB J 11:206\u2013216. https:\/\/doi.org\/10.1096\/fasebj.11.4.9068609","journal-title":"FASEB J"},{"key":"3739_CR23","doi-asserted-by":"publisher","first-page":"e97","DOI":"10.1371\/journal.pbio.0050097","volume":"5","author":"A Allali-Hassani","year":"2007","unstructured":"Allali-Hassani A, Pan PW, Dombrovski L et al (2007) Structural and chemical profiling of the human cytosolic sulfotransferases. PLoS Biol 5:e97. https:\/\/doi.org\/10.1371\/journal.pbio.0050097","journal-title":"PLoS Biol"},{"key":"3739_CR24","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1038\/s41598-022-05582-4","volume":"12","author":"EJ Brettrager","year":"2022","unstructured":"Brettrager EJ, Meehan AW, Falany CN, van Waardenburg RCAM (2022) Sulfotransferase 4A1 activity facilitates sulfate-dependent cellular protection to oxidative stress. Sci Rep 12:1625. https:\/\/doi.org\/10.1038\/s41598-022-05582-4","journal-title":"Sci Rep"},{"key":"3739_CR25","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/ajmg.b.30222","volume":"139B","author":"MD Brennan","year":"2005","unstructured":"Brennan MD, Condra J (2005) Transmission disequilibrium suggests a role for the sulfotransferase-4A1 gene in schizophrenia. Am J Med Genet Part B Neuropsychiatr Genet 139B:69\u201372. https:\/\/doi.org\/10.1002\/ajmg.b.30222","journal-title":"Am J Med Genet Part B Neuropsychiatr Genet"},{"key":"3739_CR26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1159\/000334260","volume":"2","author":"K Phelan","year":"2011","unstructured":"Phelan K, McDermid HE (2011) The 22q13.3 deletion syndrome (Phelan-McDermid syndrome). Mol Syndromol 2:186\u2013201. https:\/\/doi.org\/10.1159\/000334260","journal-title":"Mol Syndromol"},{"key":"3739_CR27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1124\/dmd.117.077560","volume":"46","author":"PL Garcia","year":"2018","unstructured":"Garcia PL, Hossain MI, Andrabi SA, Falany CN (2018) Generation and characterization of SULT4A1 mutant mouse models. Drug Metab Dispos 46:41\u201345. https:\/\/doi.org\/10.1124\/dmd.117.077560","journal-title":"Drug Metab Dispos"},{"key":"3739_CR28","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1124\/dmd.119.088047","volume":"47","author":"MI Hossain","year":"2019","unstructured":"Hossain MI, Marcus JM, Lee JH et al (2019) SULT4A1 protects against oxidative-stress induced mitochondrial dysfunction in neuronal cells. Drug Metab Dispos 47:949\u2013953. https:\/\/doi.org\/10.1124\/dmd.119.088047","journal-title":"Drug Metab Dispos"},{"key":"3739_CR29","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature18928","volume":"535","author":"K Hayakawa","year":"2016","unstructured":"Hayakawa K, Esposito E, Wang X et al (2016) Transfer of mitochondria from astrocytes to neurons after stroke. Nature 535:551\u2013555. https:\/\/doi.org\/10.1038\/nature18928","journal-title":"Nature"},{"key":"3739_CR30","doi-asserted-by":"publisher","first-page":"3142","DOI":"10.1161\/STROKEAHA.120.030152","volume":"51","author":"Y Nakamura","year":"2020","unstructured":"Nakamura Y, Lo EH, Hayakawa K (2020) Placental mitochondria therapy for cerebral ischemia-reperfusion injury in mice. Stroke 51:3142\u20133146. https:\/\/doi.org\/10.1161\/STROKEAHA.120.030152","journal-title":"Stroke"},{"key":"3739_CR31","doi-asserted-by":"publisher","first-page":"913","DOI":"10.3727\/096368915X689785","volume":"25","author":"P-J Huang","year":"2016","unstructured":"Huang P-J, Kuo C-C, Lee H-C et al (2016) Transferring xenogenic mitochondria provides neural protection against ischemic stress in ischemic rat brains. Cell Transplant 25:913\u2013927. https:\/\/doi.org\/10.3727\/096368915X689785","journal-title":"Cell Transplant"},{"key":"3739_CR32","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.bbr.2018.09.005","volume":"356","author":"Z Zhang","year":"2019","unstructured":"Zhang Z, Ma Z, Yan C et al (2019) Muscle-derived autologous mitochondrial transplantation: a novel strategy for treating cerebral ischemic injury. Behav Brain Res 356:322\u2013331. https:\/\/doi.org\/10.1016\/j.bbr.2018.09.005","journal-title":"Behav Brain Res"},{"key":"3739_CR33","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.brainresbull.2020.09.018","volume":"165","author":"Z Pourmohammadi-Bejarpasi","year":"2020","unstructured":"Pourmohammadi-Bejarpasi Z, Roushandeh AM, Saberi A et al (2020) Mesenchymal stem cells-derived mitochondria transplantation mitigates I\/R-induced injury, abolishes I\/R-induced apoptosis, and restores motor function in acute ischemia stroke rat model. Brain Res Bull 165:70\u201380. https:\/\/doi.org\/10.1016\/j.brainresbull.2020.09.018","journal-title":"Brain Res Bull"},{"key":"3739_CR34","doi-asserted-by":"publisher","first-page":"4124","DOI":"10.1007\/s12035-022-02839-x","volume":"59","author":"HA Ahmed","year":"2022","unstructured":"Ahmed HA, Ismael S, Salman M et al (2022) Direct AT2R stimulation slows post-stroke cognitive decline in the 5XFAD Alzheimer\u2019s disease mice. Mol Neurobiol 59:4124\u20134140. https:\/\/doi.org\/10.1007\/s12035-022-02839-x","journal-title":"Mol Neurobiol"},{"key":"3739_CR35","doi-asserted-by":"publisher","unstructured":"Preble JM, Pacak CA, Kondo H et al (2014) Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration. J Vis Exp. https:\/\/doi.org\/10.3791\/51682","DOI":"10.3791\/51682"},{"key":"3739_CR36","doi-asserted-by":"publisher","first-page":"105399","DOI":"10.1016\/j.nbd.2021.105399","volume":"156","author":"S Ismael","year":"2021","unstructured":"Ismael S, Nasoohi S, Li L et al (2021) Thioredoxin interacting protein regulates age-associated neuroinflammation. Neurobiol Dis 156:105399. https:\/\/doi.org\/10.1016\/j.nbd.2021.105399","journal-title":"Neurobiol Dis"},{"key":"3739_CR37","doi-asserted-by":"publisher","first-page":"114161","DOI":"10.1016\/j.expneurol.2022.114161","volume":"359","author":"S Nasoohi","year":"2023","unstructured":"Nasoohi S, Tayefeh Ghahremani P, Alehossein P et al (2023) The p75 neurotrophin receptor inhibitor, LM11A-31, ameliorates acute stroke injury and modulates astrocytic proNGF. Exp Neurol 359:114161. https:\/\/doi.org\/10.1016\/j.expneurol.2022.114161","journal-title":"Exp Neurol"},{"key":"3739_CR38","doi-asserted-by":"publisher","first-page":"2870","DOI":"10.1007\/s12035-020-01924-3","volume":"57","author":"M Salman","year":"2020","unstructured":"Salman M, Tabassum H, Parvez S (2020) Tannic acid provides neuroprotective effects against traumatic brain injury through the PGC-1\u03b1\/Nrf2\/HO-1 pathway. Mol Neurobiol 57:2870\u20132885. https:\/\/doi.org\/10.1007\/s12035-020-01924-3","journal-title":"Mol Neurobiol"},{"key":"3739_CR39","doi-asserted-by":"publisher","first-page":"983","DOI":"10.3390\/ph14100983","volume":"14","author":"M Salman","year":"2021","unstructured":"Salman M, Ismael S, Li L et al (2021) Endothelial thioredoxin-interacting protein depletion reduces hemorrhagic transformation in hyperglycemic mice after embolic stroke and thrombolytic therapy. Pharmaceuticals 14:983. https:\/\/doi.org\/10.3390\/ph14100983","journal-title":"Pharmaceuticals"},{"key":"3739_CR40","doi-asserted-by":"publisher","first-page":"105423","DOI":"10.1016\/j.neuint.2022.105423","volume":"161","author":"S Ismael","year":"2022","unstructured":"Ismael S, Patrick D, Salman M et al (2022) Verapamil inhibits TXNIP-NLRP3 inflammasome activation and preserves functional recovery after intracerebral hemorrhage in mice. Neurochem Int 161:105423. https:\/\/doi.org\/10.1016\/j.neuint.2022.105423","journal-title":"Neurochem Int"},{"key":"3739_CR41","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/WNR.0000000000001553","volume":"32","author":"X-T Xiao","year":"2021","unstructured":"Xiao X-T, Luo C, Yuan Y et al (2021) Systematic evaluation during early-phase ischemia predicts outcomes in middle cerebral artery occlusion mice. Neuroreport 32:29\u201337. https:\/\/doi.org\/10.1097\/WNR.0000000000001553","journal-title":"Neuroreport"},{"key":"3739_CR42","doi-asserted-by":"publisher","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","volume":"298","author":"NB Ruderman","year":"2010","unstructured":"Ruderman NB, Julia XX, Nelson L et al (2010) AMPK and SIRT-1: a long-standing partnership? Am J Physiol Metab 298:E751\u2013E760. https:\/\/doi.org\/10.1152\/ajpendo.00745.2009","journal-title":"Am J Physiol Metab"},{"key":"3739_CR43","doi-asserted-by":"publisher","unstructured":"Zhou Y, Wang S, Li Y et al (2018) SIRT-1\/PGC-1\u03b1 signaling promotes mitochondrial functional recovery and reduces apoptosis after intracerebral hemorrhage in rats. Front Mol Neurosci 10. https:\/\/doi.org\/10.3389\/fnmol.2017.00443","DOI":"10.3389\/fnmol.2017.00443"},{"key":"3739_CR44","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1042\/bse0470069","volume":"47","author":"FR Jornayvaz","year":"2010","unstructured":"Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69\u201384. https:\/\/doi.org\/10.1042\/bse0470069","journal-title":"Essays Biochem"},{"key":"3739_CR45","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/s12974-019-1498-0","volume":"16","author":"P Hong","year":"2019","unstructured":"Hong P, Gu R-N, Li F-X et al (2019) NLRP3 inflammasome as a potential treatment in ischemic stroke concomitant with diabetes. J Neuroinflammation 16:121. https:\/\/doi.org\/10.1186\/s12974-019-1498-0","journal-title":"J Neuroinflammation"},{"key":"3739_CR46","doi-asserted-by":"publisher","unstructured":"Salman M, Tabassum H, Parvez S (2020) Nrf2\/HO-1 mediates neuroprotective effects of pramipexole by attenuating oxidative damage and mitochondrial perturbation after traumatic brain injury. Dis Model Mech. https:\/\/doi.org\/10.1242\/dmm.045021","DOI":"10.1242\/dmm.045021"},{"key":"3739_CR47","doi-asserted-by":"publisher","first-page":"2855","DOI":"10.1007\/s12035-022-02740-7","volume":"59","author":"J Li","year":"2022","unstructured":"Li J, Gao W, Zhao Z et al (2022) Ginsenoside Rg1 reduced microglial activation and mitochondrial dysfunction to alleviate depression-like behaviour via the GAS5\/EZH2\/SOCS3\/NRF2 axis. Mol Neurobiol 59:2855\u20132873. https:\/\/doi.org\/10.1007\/s12035-022-02740-7","journal-title":"Mol Neurobiol"},{"key":"3739_CR48","doi-asserted-by":"publisher","first-page":"3320","DOI":"10.1161\/STROKEAHA.120.029951","volume":"51","author":"Y Luo","year":"2020","unstructured":"Luo Y, Fang Y, Kang R et al (2020) Inhibition of EZH2 (enhancer of zeste homolog 2) attenuates neuroinflammation via H3k27me3\/SOCS3\/TRAF6\/NF-\u03baB (trimethylation of histone 3 lysine 27\/suppressor of cytokine signaling 3\/tumor necrosis factor receptor family 6\/nuclear factor-\u03baB) in a rat mode. Stroke 51:3320\u20133331. https:\/\/doi.org\/10.1161\/STROKEAHA.120.029951","journal-title":"Stroke"},{"key":"3739_CR49","doi-asserted-by":"publisher","unstructured":"Cherait A, Maucotel J, Lefranc B et al (2021) Intranasal administration of PACAP is an efficient delivery route to reduce infarct volume and promote functional recovery after transient and permanent middle cerebral artery occlusion. Front Endocrinol (Lausanne) 11. https:\/\/doi.org\/10.3389\/fendo.2020.585082","DOI":"10.3389\/fendo.2020.585082"},{"key":"3739_CR50","doi-asserted-by":"publisher","unstructured":"Guo X, Zhang Y, Liu C et al (2022) Intranasal administration of \u03b2-1, 3-galactosyltransferase 2 confers neuroprotection against ischemic stroke by likely inhibiting oxidative stress and <scp>NLRP3<\/scp> inflammasome activation. FASEB J 36. https:\/\/doi.org\/10.1096\/fj.202200456RR","DOI":"10.1096\/fj.202200456RR"},{"key":"3739_CR51","doi-asserted-by":"publisher","first-page":"106226","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106226","volume":"31","author":"M Salman","year":"2022","unstructured":"Salman M, Ismael S, Li L et al (2022) Acute hyperglycemia exacerbates hemorrhagic transformation after embolic stroke and reperfusion with tPA: a possible role of TXNIP-NLRP3 inflammasome. J Stroke Cerebrovasc Dis 31:106226. https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.106226","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"3739_CR52","doi-asserted-by":"publisher","first-page":"2495","DOI":"10.1007\/s12035-020-01893-7","volume":"57","author":"S Ismael","year":"2020","unstructured":"Ismael S, Nasoohi S, Yoo A et al (2020) Tissue plasminogen activator promotes TXNIP-NLRP3 inflammasome activation after hyperglycemic stroke in mice. Mol Neurobiol 57:2495\u20132508. https:\/\/doi.org\/10.1007\/s12035-020-01893-7","journal-title":"Mol Neurobiol"},{"key":"3739_CR53","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1007\/s11064-018-2604-x","volume":"43","author":"T Ishrat","year":"2018","unstructured":"Ishrat T, Soliman S, Eldahshan W et al (2018) Silencing VEGF-B diminishes the neuroprotective effect of candesartan treatment after experimental focal cerebral ischemia. Neurochem Res 43:1869\u20131878. https:\/\/doi.org\/10.1007\/s11064-018-2604-x","journal-title":"Neurochem Res"},{"key":"3739_CR54","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.freeradbiomed.2022.03.020","volume":"183","author":"J-Y Lee","year":"2022","unstructured":"Lee J-Y, Castelli V, Kumar N et al (2022) Contraceptive drug, Nestorone, enhances stem cell-mediated remodeling of the stroke brain by dampening inflammation and rescuing mitochondria. Free Radic Biol Med 183:138\u2013145. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.03.020","journal-title":"Free Radic Biol Med"},{"key":"3739_CR55","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1089\/ars.2010.3576","volume":"14","author":"H Chen","year":"2011","unstructured":"Chen H, Yoshioka H, Kim GS et al (2011) Oxidative stress in ischemic brain damage: mechanisms of cell death and potential molecular targets for neuroprotection. Antioxid Redox Signal 14:1505\u20131517. https:\/\/doi.org\/10.1089\/ars.2010.3576","journal-title":"Antioxid Redox Signal"},{"key":"3739_CR56","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.expneurol.2014.10.017","volume":"263","author":"PS Garry","year":"2015","unstructured":"Garry PS, Ezra M, Rowland MJ et al (2015) The role of the nitric oxide pathway in brain injury and its treatment \u2014 from bench to bedside. Exp Neurol 263:235\u2013243. https:\/\/doi.org\/10.1016\/j.expneurol.2014.10.017","journal-title":"Exp Neurol"},{"key":"3739_CR57","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1124\/pr.108.000547","volume":"61","author":"N Toda","year":"2009","unstructured":"Toda N, Ayajiki K, Okamura T (2009) Cerebral blood flow regulation by nitric oxide: recent advances. Pharmacol Rev 61:62\u201397. https:\/\/doi.org\/10.1124\/pr.108.000547","journal-title":"Pharmacol Rev"},{"key":"3739_CR58","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1093\/jnen\/62.2.127","volume":"62","author":"GH Danton","year":"2003","unstructured":"Danton GH, Dietrich WD (2003) Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62:127\u2013136. https:\/\/doi.org\/10.1093\/jnen\/62.2.127","journal-title":"J Neuropathol Exp Neurol"},{"key":"3739_CR59","doi-asserted-by":"publisher","first-page":"5971","DOI":"10.1038\/s41598-018-24350-x","volume":"8","author":"S Ismael","year":"2018","unstructured":"Ismael S, Zhao L, Nasoohi S, Ishrat T (2018) Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Sci Rep 8:5971. https:\/\/doi.org\/10.1038\/s41598-018-24350-x","journal-title":"Sci Rep"},{"key":"3739_CR60","doi-asserted-by":"publisher","first-page":"e790","DOI":"10.1038\/cddis.2013.326","volume":"4","author":"D Yang-Wei Fann","year":"2013","unstructured":"Yang-Wei Fann D, Lee S-Y, Manzanero S et al (2013) Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke. Cell Death Dis 4:e790\u2013e790. https:\/\/doi.org\/10.1038\/cddis.2013.326","journal-title":"Cell Death Dis"},{"key":"3739_CR61","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang F, Wang Z, Wei X et al (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab 34:660\u2013667. https:\/\/doi.org\/10.1038\/jcbfm.2013.242","journal-title":"J Cereb Blood Flow Metab"},{"key":"3739_CR62","doi-asserted-by":"publisher","first-page":"1584","DOI":"10.1021\/jf9035782","volume":"58","author":"J-N Lin","year":"2010","unstructured":"Lin J-N, Lin VC-H, Rau K-M et al (2010) Resveratrol modulates tumor cell proliferation and protein translation via SIRT-1-dependent AMPK activation. J Agric Food Chem 58:1584\u20131592. https:\/\/doi.org\/10.1021\/jf9035782","journal-title":"J Agric Food Chem"},{"key":"3739_CR63","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1002\/ana.22236","volume":"69","author":"P Wang","year":"2011","unstructured":"Wang P, Xu T-Y, Guan Y-F et al (2011) Nicotinamide phosphoribosyltransferase protects against ischemic stroke through SIRT-1-dependent adenosine monophosphate-activated kinase pathway. Ann Neurol 69:360\u2013374. https:\/\/doi.org\/10.1002\/ana.22236","journal-title":"Ann Neurol"},{"key":"3739_CR64","doi-asserted-by":"publisher","first-page":"21379","DOI":"10.1074\/jbc.M109.018911","volume":"284","author":"P Wareski","year":"2009","unstructured":"Wareski P, Vaarmann A, Choubey V et al (2009) PGC-1\u03b1 and PGC-1\u0392 regulate mitochondrial density in neurons. J Biol Chem 284:21379\u201321385. https:\/\/doi.org\/10.1074\/jbc.M109.018911","journal-title":"J Biol Chem"},{"key":"3739_CR65","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1186\/s12967-023-04414-x","volume":"15","author":"Y Awad-Igbaria","year":"2023","unstructured":"Awad-Igbaria Y, Ferreira N, Keadan A, Sakas R, Edelman D, Shamir A, Francous-Soustiel J et al (2023) HBO treatment enhances motor function and modulates pain development after sciatic nerve injury via protection the mitochondrial function. J Transl Med. 15:545. https:\/\/doi.org\/10.1186\/s12967-023-04414-x","journal-title":"J Transl Med."},{"key":"3739_CR66","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.febslet.2007.11.034","volume":"582","author":"JT Rodgers","year":"2008","unstructured":"Rodgers JT, Lerin C, Gerhart-Hines Z, Puigserver P (2008) Metabolic adaptations through the PGC-1\u03b1 and SIRT-1 pathways. FEBS Lett 582:46\u201353. https:\/\/doi.org\/10.1016\/j.febslet.2007.11.034","journal-title":"FEBS Lett"},{"key":"3739_CR67","doi-asserted-by":"publisher","first-page":"1596","DOI":"10.1210\/me.2007-0388","volume":"22","author":"H Wang","year":"2008","unstructured":"Wang H, Peiris TH, Mowery A et al (2008) CCAAT\/enhancer binding protein-\u03b2 is a transcriptional regulator of peroxisome-proliferator-activated receptor-\u03b3 coactivator-1\u03b1 in the regenerating liver. Mol Endocrinol 22:1596\u20131605. https:\/\/doi.org\/10.1210\/me.2007-0388","journal-title":"Mol Endocrinol"},{"key":"3739_CR68","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1007\/s13238-013-2124-z","volume":"4","author":"L Han","year":"2013","unstructured":"Han L, Wang P, Zhao G et al (2013) Upregulation of SIRT-1 by 17\u03b2-estradiol depends on ubiquitin-proteasome degradation of PPAR-\u03b3 mediated by NEDD4-1. Protein Cell 4:310\u2013321. https:\/\/doi.org\/10.1007\/s13238-013-2124-z","journal-title":"Protein Cell"},{"key":"3739_CR69","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.neuroscience.2014.09.058","volume":"281","author":"B Fu","year":"2014","unstructured":"Fu B, Zhang J, Zhang X et al (2014) Alpha-lipoic acid upregulates SIRT-1-dependent PGC-1\u03b1 expression and protects mouse brain against focal ischemia. Neuroscience 281:251\u2013257. https:\/\/doi.org\/10.1016\/j.neuroscience.2014.09.058","journal-title":"Neuroscience"},{"key":"3739_CR70","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/bs.irn.2019.04.002","volume":"145","author":"K Chandrasekaran","year":"2019","unstructured":"Chandrasekaran K, Anjaneyulu M, Choi J et al (2019) Role of mitochondria in diabetic peripheral neuropathy: influencing the NAD+-dependent SIRT-1\u2013PGC-1\u03b1\u2013TFAM pathway. Int Rev Neurobiol 145:177\u2013209. https:\/\/doi.org\/10.1016\/bs.irn.2019.04.002","journal-title":"Int Rev Neurobiol"},{"key":"3739_CR71","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1007\/s12035-013-8460-4","volume":"48","author":"Z Gao","year":"2013","unstructured":"Gao Z, Zhu Q, Zhang Y et al (2013) Reciprocal modulation between microglia and astrocyte in reactive gliosis following the CNS injury. Mol Neurobiol 48:690\u2013701. https:\/\/doi.org\/10.1007\/s12035-013-8460-4","journal-title":"Mol Neurobiol"},{"key":"3739_CR72","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1016\/S1474-4422(16)00114-9","volume":"15","author":"\u00c1 Chamorro","year":"2016","unstructured":"Chamorro \u00c1, Dirnagl U, Urra X, Planas AM (2016) Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation. Lancet Neurol 15:869\u2013881. https:\/\/doi.org\/10.1016\/S1474-4422(16)00114-9","journal-title":"Lancet Neurol"},{"key":"3739_CR73","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jneuroim.2006.11.014","volume":"184","author":"Q Wang","year":"2007","unstructured":"Wang Q, Tang X, Yenari M (2007) The inflammatory response in stroke. J Neuroimmunol 184:53\u201368. https:\/\/doi.org\/10.1016\/j.jneuroim.2006.11.014","journal-title":"J Neuroimmunol"},{"key":"3739_CR74","doi-asserted-by":"publisher","first-page":"172452","DOI":"10.1016\/j.ejphar.2019.172452","volume":"857","author":"J Chen","year":"2019","unstructured":"Chen J, Zhang M, Zhang X et al (2019) EZH2 inhibitor DZNep modulates microglial activation and protects against ischaemic brain injury after experimental stroke. Eur J Pharmacol 857:172452. https:\/\/doi.org\/10.1016\/j.ejphar.2019.172452","journal-title":"Eur J Pharmacol"},{"key":"3739_CR75","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1016\/j.apsb.2020.11.002","volume":"11","author":"T He","year":"2021","unstructured":"He T, Shang J, Gao C et al (2021) A novel SIRT6 activator ameliorates neuroinflammation and ischemic brain injury via EZH2\/FOXC1 axis. Acta Pharm Sin B 11:708\u2013726. https:\/\/doi.org\/10.1016\/j.apsb.2020.11.002","journal-title":"Acta Pharm Sin B"},{"key":"3739_CR76","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s11055-016-0231-z","volume":"46","author":"DE Korzhevskii","year":"2016","unstructured":"Korzhevskii DE, Kirik OV (2016) Brain microglia and microglial markers. Neurosci Behav Physiol 46:284\u2013290. https:\/\/doi.org\/10.1007\/s11055-016-0231-z","journal-title":"Neurosci Behav Physiol"},{"key":"3739_CR77","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12974-018-1379-y","volume":"16","author":"WP Yew","year":"2019","unstructured":"Yew WP, Djukic ND, Jayaseelan JSP et al (2019) Early treatment with minocycline following a stroke in rats improves functional recovery and differentially modifies responses of peri-infarct microglia and astrocytes. J Neuroinflammation 16:6. https:\/\/doi.org\/10.1186\/s12974-018-1379-y","journal-title":"J Neuroinflammation"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03739-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03739-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03739-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T05:31:34Z","timestamp":1713936694000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03739-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,9]]},"references-count":77,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["3739"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03739-4","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,9]]},"assertion":[{"value":"5 January 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"All procedures related to animal studies were approved by the institutional animal committee at UTHSC in full accordance with the ethical guidelines of the National Institutes of Health for the care and use of laboratory animals.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have agreed to publish this manuscript.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}