{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:33:20Z","timestamp":1772120000740,"version":"3.50.1"},"reference-count":154,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T00:00:00Z","timestamp":1700179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002958","name":"Drug Applied Research Center, Tabriz University of Medical Sciences","doi-asserted-by":"publisher","award":["65698"],"award-info":[{"award-number":["65698"]}],"id":[{"id":"10.13039\/501100002958","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1007\/s12035-023-03763-4","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T03:02:57Z","timestamp":1700190177000},"page":"3121-3143","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic Sustained Hypoxia Leads to Brainstem Tauopathy and Declines the Power of Rhythms in the Ventrolateral Medulla: Shedding Light on a Possible Mechanism"],"prefix":"10.1007","volume":"61","author":[{"given":"Jamal","family":"Khalilpour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6979-0723","authenticated-orcid":false,"given":"Hamid Soltani","family":"Zangbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Reza","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Firouz Qaderi","family":"Pakdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohre","family":"Zavari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-5544","authenticated-orcid":false,"given":"Parviz","family":"Shahabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"issue":"9","key":"3763_CR1","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1007\/s00018-019-03039-y","volume":"76","author":"LW Thomas","year":"2019","unstructured":"Thomas LW, Ashcroft M (2019) Exploring the molecular interface between hypoxia-inducible factor signalling and mitochondria. Cell Mol Life Sci 76(9):1759\u20131777","journal-title":"Cell Mol Life Sci"},{"issue":"9","key":"3763_CR2","doi-asserted-by":"publisher","first-page":"884","DOI":"10.5551\/jat.RV17009","volume":"24","author":"H Abe","year":"2017","unstructured":"Abe H, Semba H, Takeda N (2017) The roles of hypoxia signaling in the pathogenesis of cardiovascular diseases. J Atheroscler Thromb 24(9):884\u2013894","journal-title":"J Atheroscler Thromb"},{"key":"3763_CR3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.116258","volume":"154","author":"MB Brent","year":"2022","unstructured":"Brent MB (2022) A review of the skeletal effects of exposure to high altitude and potential mechanisms for hypobaric hypoxia-induced bone loss. Bone 154:116258","journal-title":"Bone"},{"issue":"11","key":"3763_CR4","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.3357\/ASEM.3661.2013","volume":"84","author":"D Asmaro","year":"2013","unstructured":"Asmaro D, Mayall J, Ferguson S (2013) Cognition at altitude: impairment in executive and memory processes under hypoxic conditions. Aviat Space Environ Med 84(11):1159\u20131165","journal-title":"Aviat Space Environ Med"},{"key":"3763_CR5","first-page":"199","volume":"6","author":"BD Kent","year":"2011","unstructured":"Kent BD, Mitchell PD, McNicholas WT (2011) Hypoxemia in patients with COPD: cause, effects, and disease progression. Int J Chron Obstruct Pulmon Dis 6:199","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"3","key":"3763_CR6","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1111\/j.1471-4159.2006.04212.x","volume":"99","author":"DH Small","year":"2006","unstructured":"Small DH, Cappai R (2006) Alois Alzheimer and Alzheimer\u2019s disease: a centennial perspective. J Neurochem 99(3):708\u2013710","journal-title":"J Neurochem"},{"issue":"12","key":"3763_CR7","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1038\/nrneurol.2013.223","volume":"9","author":"E Giacobini","year":"2013","unstructured":"Giacobini E, Gold G (2013) Alzheimer disease therapy\u2014moving from amyloid-\u03b2 to tau. Nat Rev Neurol 9(12):677\u2013686","journal-title":"Nat Rev Neurol"},{"issue":"4","key":"3763_CR8","first-page":"1141","volume":"58","author":"DFV P\u00eer\u015fcoveanu","year":"2017","unstructured":"P\u00eer\u015fcoveanu DFV, Pirici I, Tudoric\u0103 V, B\u0103l\u015feanu TA, Albu VC, Bondari S, Bumbea AM, P\u00eer\u015fcoveanu M (2017) Tau protein in neurodegenerative diseases - a review. Rom J Morphol Embryol 58(4):1141\u20131150","journal-title":"Rom J Morphol Embryol"},{"issue":"Pt 6","key":"3763_CR9","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1242\/jcs.109.6.1537","volume":"109","author":"U Wagner","year":"1996","unstructured":"Wagner U et al (1996) Cellular phosphorylation of tau by GSK-3 beta influences tau binding to microtubules and microtubule organisation. J Cell Sci 109(Pt 6):1537\u20131543","journal-title":"J Cell Sci"},{"key":"3763_CR10","doi-asserted-by":"publisher","first-page":"65","DOI":"10.3389\/fnmol.2014.00065","volume":"7","author":"T Kimura","year":"2014","unstructured":"Kimura T, Ishiguro K, Hisanaga S (2014) Physiological and pathological phosphorylation of tau by Cdk5. Front Mol Neurosci 7:65","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"3763_CR11","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1038\/nrn.2015.1","volume":"17","author":"Y Wang","year":"2016","unstructured":"Wang Y, Mandelkow E (2016) Tau in physiology and pathology. Nat Rev Neurosci 17(1):5\u201321","journal-title":"Nat Rev Neurosci"},{"key":"3763_CR12","doi-asserted-by":"crossref","unstructured":"Chen K (2020) Phosphorylation of the tau protein in neurodegenerative disease. Biomed J Sci Tech Res 26(4)","DOI":"10.26717\/BJSTR.2020.26.004393"},{"issue":"3","key":"3763_CR13","doi-asserted-by":"publisher","first-page":"4671","DOI":"10.3390\/ijms15034671","volume":"15","author":"A Mietelska-Porowska","year":"2014","unstructured":"Mietelska-Porowska A et al (2014) Tau protein modifications and interactions: their role in function and dysfunction. Int J Mol Sci 15(3):4671\u20134713","journal-title":"Int J Mol Sci"},{"key":"3763_CR14","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.607680","volume":"11","author":"A Duquette","year":"2021","unstructured":"Duquette A et al (2021) Similarities and differences in the pattern of tau hyperphosphorylation in physiological and pathological conditions: impacts on the elaboration of therapies to prevent tau pathology. Front Neurol 11:607680","journal-title":"Front Neurol"},{"issue":"4","key":"3763_CR15","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.biopsych.2021.02.973","volume":"91","author":"SF Kazim","year":"2022","unstructured":"Kazim SF et al (2022) Chronic intermittent hypoxia enhances pathological tau seeding, propagation, and accumulation and exacerbates Alzheimer-like memory and synaptic plasticity deficits and molecular signatures. Biol Psychiatry 91(4):346\u2013358","journal-title":"Biol Psychiatry"},{"key":"3763_CR16","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.nbd.2018.07.009","volume":"126","author":"L Raz","year":"2019","unstructured":"Raz L et al (2019) Hypoxia promotes tau hyperphosphorylation with associated neuropathology in vascular dysfunction. Neurobiol Dis 126:124\u2013136","journal-title":"Neurobiol Dis"},{"issue":"1","key":"3763_CR17","doi-asserted-by":"publisher","first-page":"23964","DOI":"10.1038\/srep23964","volume":"6","author":"L Qiu","year":"2016","unstructured":"Qiu L et al (2016) Chronic cerebral hypoperfusion enhances tau hyperphosphorylation and reduces autophagy in Alzheimer\u2019s disease mice. Sci Rep 6(1):23964","journal-title":"Sci Rep"},{"issue":"1","key":"3763_CR18","doi-asserted-by":"publisher","first-page":"13917","DOI":"10.1038\/srep13917","volume":"5","author":"X-L Bu","year":"2015","unstructured":"Bu X-L et al (2015) Serum amyloid-beta levels are increased in patients with obstructive sleep apnea syndrome. Sci Rep 5(1):13917","journal-title":"Sci Rep"},{"issue":"2","key":"3763_CR19","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.jalz.2015.05.019","volume":"12","author":"H Liu","year":"2016","unstructured":"Liu H et al (2016) Chronic hypoxia facilitates Alzheimer\u2019s disease through demethylation of \u03b3-secretase by downregulating DNA methyltransferase 3b. Alzheimers Dement 12(2):130\u2013143","journal-title":"Alzheimers Dement"},{"key":"3763_CR20","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/j.nlm.2016.05.011","volume":"133","author":"S Biswal","year":"2016","unstructured":"Biswal S et al (2016) Global hypoxia induced impairment in learning and spatial memory is associated with precocious hippocampal aging. Neurobiol Learn Mem 133:157\u2013170","journal-title":"Neurobiol Learn Mem"},{"key":"3763_CR21","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3233\/JAD-2003-5305","volume":"5","author":"G-J Chen","year":"2003","unstructured":"Chen G-J et al (2003) Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J Alzheimers Dis 5:209\u2013228","journal-title":"J Alzheimers Dis"},{"key":"3763_CR22","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/742059","volume":"2015","author":"K Jain","year":"2015","unstructured":"Jain K et al (2015) Hypobaric hypoxia imbalances mitochondrial dynamics in rat brain hippocampus. Neurol Res Int 2015:742059","journal-title":"Neurol Res Int"},{"issue":"2","key":"3763_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.14336\/AD.2015.1007","volume":"7","author":"IG Onyango","year":"2016","unstructured":"Onyango IG, Dennis J, Khan SM (2016) Aging Dis 7(2):201\u2013214","journal-title":"Aging Dis"},{"key":"3763_CR24","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.mito.2019.07.003","volume":"49","author":"Y Wu","year":"2019","unstructured":"Wu Y, Chen M, Jiang J (2019) Mitochondrial dysfunction in neurodegenerative diseases and drug targets via apoptotic signaling. Mitochondrion 49:35\u201345","journal-title":"Mitochondrion"},{"issue":"4","key":"3763_CR25","doi-asserted-by":"publisher","first-page":"754","DOI":"10.4103\/1673-5374.322430","volume":"17","author":"F Rey","year":"2022","unstructured":"Rey F et al (2022) Mitochondrial dysfunctions in neurodegenerative diseases: role in disease pathogenesis, strategies for analysis and therapeutic prospects. Neural Regen Res 17(4):754","journal-title":"Neural Regen Res"},{"issue":"2","key":"3763_CR26","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.molcel.2012.09.025","volume":"48","author":"LA Sena","year":"2012","unstructured":"Sena LA, Chandel NS (2012) Physiological roles of mitochondrial reactive oxygen species. Mol Cell 48(2):158\u2013167","journal-title":"Mol Cell"},{"issue":"1","key":"3763_CR27","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/13510002.2022.2046423","volume":"27","author":"B Zhang","year":"2022","unstructured":"Zhang B et al (2022) Role of mitochondrial reactive oxygen species in homeostasis regulation. Redox Rep 27(1):45\u201352","journal-title":"Redox Rep"},{"issue":"6","key":"3763_CR28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000536","volume":"2","author":"S Melov","year":"2007","unstructured":"Melov S et al (2007) Mitochondrial oxidative stress causes hyperphosphorylation of tau. PLoS ONE 2(6):e536","journal-title":"PLoS ONE"},{"issue":"2","key":"3763_CR29","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s11910-011-0248-1","volume":"12","author":"C Gaig","year":"2012","unstructured":"Gaig C, Iranzo A (2012) Sleep-disordered breathing in neurodegenerative diseases. Curr Neurol Neurosci Rep 12(2):205\u2013217","journal-title":"Curr Neurol Neurosci Rep"},{"issue":"5","key":"3763_CR30","doi-asserted-by":"publisher","first-page":"2000523","DOI":"10.1183\/13993003.00523-2020","volume":"56","author":"C Jorge","year":"2020","unstructured":"Jorge C et al (2020) Obstructive sleep apnoea and cognitive decline in mild-to-moderate Alzheimer\u2019s disease. Eur Respir J 56(5):2000523","journal-title":"Eur Respir J"},{"issue":"12","key":"3763_CR31","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1111\/jgs.12553","volume":"61","author":"RH Affoo","year":"2013","unstructured":"Affoo RH et al (2013) Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer\u2019s disease: a scoping review of the evidence. J Am Geriatr Soc 61(12):2203\u20132213","journal-title":"J Am Geriatr Soc"},{"issue":"5","key":"3763_CR32","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1523\/JNEUROSCI.5261-09.2010","volume":"30","author":"M Dutschmann","year":"2010","unstructured":"Dutschmann M et al (2010) Upper airway dysfunction of tau-P301L mice correlates with tauopathy in midbrain and ponto-medullary brainstem nuclei. J Neurosci 30(5):1810\u20131821","journal-title":"J Neurosci"},{"key":"3763_CR33","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.3233\/JAD-160974","volume":"56","author":"DL Ebel","year":"2017","unstructured":"Ebel DL, Torkilsen CG, Ostrowski TD (2017) Blunted respiratory responses in the streptozotocin-induced Alzheimer\u2019s disease rat model. J Alzheimers Dis 56:1197\u20131211","journal-title":"J Alzheimers Dis"},{"key":"3763_CR34","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.852368","volume":"15","author":"AJ Trease","year":"2022","unstructured":"Trease AJ et al (2022) Hyperphosphorylated human tau accumulates at the synapse, localizing on synaptic mitochondrial outer membranes and disrupting respiration in a mouse model of tauopathy. Front Mol Neurosci 15:852368","journal-title":"Front Mol Neurosci"},{"issue":"6","key":"3763_CR35","doi-asserted-by":"publisher","first-page":"3370","DOI":"10.1152\/jn.00985.2007","volume":"98","author":"JC Smith","year":"2007","unstructured":"Smith JC et al (2007) Spatial and functional architecture of the mammalian brain stem respiratory network: a hierarchy of three oscillatory mechanisms. J Neurophysiol 98(6):3370\u20133387","journal-title":"J Neurophysiol"},{"issue":"5032","key":"3763_CR36","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1126\/science.1683005","volume":"254","author":"JC Smith","year":"1991","unstructured":"Smith JC et al (1991) Pre-B\u00f6tzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 254(5032):726\u2013729","journal-title":"Science"},{"issue":"3","key":"3763_CR37","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/BF02423514","volume":"81","author":"C Jiang","year":"1990","unstructured":"Jiang C, Lipski J (1990) Extensive monosynaptic inhibition of ventral respiratory group neurons by augmenting neurons in the B\u00f6tzinger complex in the cat. Exp Brain Res 81(3):639\u2013648","journal-title":"Exp Brain Res"},{"key":"3763_CR38","doi-asserted-by":"crossref","unstructured":"Garcia AJ et al (2016) Chronic intermittent hypoxia alters local respiratory circuit function at the level of the preB\u00f6tzinger complex. Front Neurosci 10","DOI":"10.3389\/fnins.2016.00004"},{"issue":"1","key":"3763_CR39","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1203\/00006450-200207000-00011","volume":"52","author":"P Kiatchoosakun","year":"2002","unstructured":"Kiatchoosakun P et al (2002) Effects of hypoxia on respiratory neural output and lower esophageal sphincter pressure in piglets. Pediatr Res 52(1):50\u201355","journal-title":"Pediatr Res"},{"issue":"3","key":"3763_CR40","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1152\/jappl.1995.78.3.856","volume":"78","author":"SJ England","year":"1995","unstructured":"England SJ et al (1995) Activity of respiratory neurons during hypoxia in the chemodenervated cat. J Appl Physiol 78(3):856\u2013861","journal-title":"J Appl Physiol"},{"key":"3763_CR41","doi-asserted-by":"publisher","first-page":"2601","DOI":"10.1007\/978-3-540-29678-2_3800","volume-title":"Encyclopedia of neuroscience","author":"DW Richter","year":"2009","unstructured":"Richter DW, M\u00fcller M (2009) Neural respiratory control during acute hypoxia. In: Binder MD, Hirokawa N, Windhorst U (eds) Encyclopedia of neuroscience. Springer, Berlin Heidelberg, Berlin, pp 2601\u20132606"},{"issue":"12","key":"3763_CR42","doi-asserted-by":"publisher","first-page":"5562","DOI":"10.1073\/pnas.91.12.5562","volume":"91","author":"AC Alonso","year":"1994","unstructured":"Alonso AC et al (1994) Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer\u2019s disease. Proc Natl Acad Sci 91(12):5562\u20135566","journal-title":"Proc Natl Acad Sci"},{"key":"3763_CR43","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.neuroscience.2022.06.025","volume":"498","author":"C Nishioka","year":"2022","unstructured":"Nishioka C et al (2022) Axonal transport impairment and its relationship with diffusion tensor imaging metrics of a murine model of p301L tau induced tauopathy. Neuroscience 498:144\u2013154","journal-title":"Neuroscience"},{"issue":"5","key":"3763_CR44","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1016\/j.neuron.2015.01.025","volume":"85","author":"N Menkes-Caspi","year":"2015","unstructured":"Menkes-Caspi N et al (2015) Pathological tau disrupts ongoing network activity. Neuron 85(5):959\u2013966","journal-title":"Neuron"},{"key":"3763_CR45","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.bbr.2018.10.026","volume":"359","author":"V Maleysson","year":"2019","unstructured":"Maleysson V et al (2019) Relevance of electroencephalogram assessment in amyloid and tau pathology in rat. Behav Brain Res 359:127\u2013134","journal-title":"Behav Brain Res"},{"issue":"11","key":"3763_CR46","doi-asserted-by":"publisher","first-page":"1689","DOI":"10.1111\/cns.13942","volume":"28","author":"Y Xu","year":"2022","unstructured":"Xu Y, Fan Q (2022) Relationship between chronic hypoxia and seizure susceptibility. CNS Neurosci Ther 28(11):1689\u20131705","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"3763_CR47","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/cphy.c150026","volume":"6","author":"ME Pamenter","year":"2016","unstructured":"Pamenter ME, Powell FL (2016) Time domains of the hypoxic ventilatory response and their molecular basis. Compr Physiol 6(3):1345\u20131385","journal-title":"Compr Physiol"},{"issue":"4","key":"3763_CR48","doi-asserted-by":"publisher","first-page":"965","DOI":"10.1016\/j.ijrobp.2011.02.049","volume":"80","author":"C Bayer","year":"2011","unstructured":"Bayer C et al (2011) Acute versus chronic hypoxia: why a simplified classification is simply not enough. Int J Radiat Oncol Biol Phys 80(4):965\u2013968","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"3763_CR49","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neulet.2012.11.062","volume":"534","author":"F Hossienzadeh","year":"2013","unstructured":"Hossienzadeh F et al (2013) Effect of ghrelin on brain edema induced by acute and chronic systemic hypoxia. Neurosci Lett 534:47\u201351","journal-title":"Neurosci Lett"},{"issue":"13","key":"3763_CR50","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1002\/cne.23334","volume":"521","author":"HH Subramanian","year":"2013","unstructured":"Subramanian HH, Holstege G (2013) Stimulation of the midbrain periaqueductal gray modulates preinspiratory neurons in the ventrolateral medulla in the rat in vivo. J Comp Neurol 521(13):3083\u20133098","journal-title":"J Comp Neurol"},{"issue":"1","key":"3763_CR51","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.jneumeth.2003.10.009","volume":"134","author":"A Delorme","year":"2004","unstructured":"Delorme A, Makeig S (2004) EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. J Neurosci Methods 134(1):9\u201321","journal-title":"J Neurosci Methods"},{"key":"3763_CR52","volume-title":"Statistical digital signal processing and modeling","author":"MH Hayes","year":"1996","unstructured":"Hayes MH (1996) Statistical digital signal processing and modeling. Wiley"},{"issue":"12","key":"3763_CR53","doi-asserted-by":"publisher","first-page":"2451","DOI":"10.1002\/jnr.24719","volume":"98","author":"H Soltani Zangbar","year":"2020","unstructured":"Soltani Zangbar H et al (2020) A potential entanglement between the spinal cord and hippocampus: theta rhythm correlates with neurogenesis deficiency following spinal cord injury in male rats. J Neurosci Res 98(12):2451\u20132467","journal-title":"J Neurosci Res"},{"key":"3763_CR54","first-page":"3","volume-title":"Methods in cell biology","author":"P-C Liao","year":"2020","unstructured":"Liao P-C et al (2020) Chapter 1 - isolation of mitochondria from cells and tissues. In: Pon LA, Schon EA (eds) Methods in cell biology. Academic Press, pp 3\u201331"},{"issue":"3","key":"3763_CR55","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1177\/1074248419882002","volume":"25","author":"L Hosseini","year":"2020","unstructured":"Hosseini L, Vafaee MS, Badalzadeh R (2020) Melatonin and nicotinamide mononucleotide attenuate myocardial ischemia\/reperfusion injury via modulation of mitochondrial function and hemodynamic parameters in aged rats. J Cardiovasc Pharmacol Ther 25(3):240\u2013250","journal-title":"J Cardiovasc Pharmacol Ther"},{"issue":"5","key":"3763_CR56","doi-asserted-by":"publisher","first-page":"924","DOI":"10.14336\/AD.2017.1126","volume":"9","author":"F Liu","year":"2018","unstructured":"Liu F et al (2018) Mitochondria in ischemic stroke: new insight and implications. Aging Dis 9(5):924\u2013937","journal-title":"Aging Dis"},{"key":"3763_CR57","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13024-020-00376-6","volume":"15","author":"W Wang","year":"2020","unstructured":"Wang W et al (2020) Mitochondria dysfunction in the pathogenesis of Alzheimer\u2019s disease: recent advances. Mol Neurodegener 15:1\u201322","journal-title":"Mol Neurodegener"},{"issue":"Pt 2","key":"3763_CR58","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1113\/jphysiol.2003.049478","volume":"552","author":"JF Turrens","year":"2003","unstructured":"Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552(Pt 2):335\u2013344","journal-title":"J Physiol"},{"issue":"1","key":"3763_CR59","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0014-5793(97)01159-9","volume":"416","author":"SS Korshunov","year":"1997","unstructured":"Korshunov SS, Skulachev VP, Starkov AA (1997) High protonic potential actuates a mechanism of production of reactive oxygen species in mitochondria. FEBS Lett 416(1):15\u201318","journal-title":"FEBS Lett"},{"issue":"3\u20134","key":"3763_CR60","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1159\/000046886","volume":"10","author":"MM Sugrue","year":"2001","unstructured":"Sugrue MM, Tatton WG (2001) Mitochondrial membrane potential in aging cells. Biol Signals Recept 10(3\u20134):176\u2013188","journal-title":"Biol Signals Recept"},{"issue":"4","key":"3763_CR61","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1161\/01.RES.0000258450.44413.96","volume":"100","author":"NR Madamanchi","year":"2007","unstructured":"Madamanchi NR, Runge MS (2007) Mitochondrial dysfunction in atherosclerosis. Circ Res 100(4):460\u2013473","journal-title":"Circ Res"},{"issue":"4","key":"3763_CR62","doi-asserted-by":"publisher","first-page":"G772","DOI":"10.1152\/ajpgi.00425.2005","volume":"290","author":"S Ohashi","year":"2006","unstructured":"Ohashi S et al (2006) Protective roles of redox-active protein thioredoxin-1 for severe acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 290(4):G772-81","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"8","key":"3763_CR63","doi-asserted-by":"publisher","first-page":"118","DOI":"10.4103\/0973-7847.70902","volume":"4","author":"V Lobo","year":"2010","unstructured":"Lobo V et al (2010) Free radicals, antioxidants and functional foods: impact on human health. Pharmacogn Rev 4(8):118\u2013126","journal-title":"Pharmacogn Rev"},{"issue":"2","key":"3763_CR64","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.expneurol.2009.03.042","volume":"218","author":"PH Reddy","year":"2009","unstructured":"Reddy PH (2009) Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer\u2019s disease. Exp Neurol 218(2):286\u2013292","journal-title":"Exp Neurol"},{"issue":"22","key":"3763_CR65","doi-asserted-by":"publisher","first-page":"6011","DOI":"10.1523\/JNEUROSCI.1189-06.2006","volume":"26","author":"A Deshpande","year":"2006","unstructured":"Deshpande A et al (2006) Different conformations of amyloid beta induce neurotoxicity by distinct mechanisms in human cortical neurons. J Neurosci 26(22):6011\u20136018","journal-title":"J Neurosci"},{"key":"3763_CR66","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/509654","volume":"2015","author":"FA Cabezas-Opazo","year":"2015","unstructured":"Cabezas-Opazo FA et al (2015) Mitochondrial dysfunction contributes to the pathogenesis of Alzheimer\u2019s disease. Oxid Med Cell Longev 2015:509654","journal-title":"Oxid Med Cell Longev"},{"issue":"6\u20137","key":"3763_CR67","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/j.bbabio.2010.02.016","volume":"1797","author":"MA Aon","year":"2010","unstructured":"Aon MA, Cortassa S, O\u2019Rourke B (2010) Redox-optimized ROS balance: a unifying hypothesis. Biochim Biophys Acta 1797(6\u20137):865\u2013877","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"3763_CR68","doi-asserted-by":"publisher","first-page":"1017","DOI":"10.1007\/s11357-012-9421-y","volume":"35","author":"Q Fan","year":"2013","unstructured":"Fan Q et al (2013) Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia\/reperfusion in both humans and rats. Age (Dordr) 35(4):1017\u20131026","journal-title":"Age (Dordr)"},{"issue":"4","key":"3763_CR69","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.mad.2004.01.003","volume":"125","author":"V Calabrese","year":"2004","unstructured":"Calabrese V et al (2004) Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state. Mech Ageing Dev 125(4):325\u2013335","journal-title":"Mech Ageing Dev"},{"issue":"4","key":"3763_CR70","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1002\/ana.410340416","volume":"34","author":"P Mecocci","year":"1993","unstructured":"Mecocci P et al (1993) Oxidative damage to mitochondrial DNA shows marked age-dependent increases in human brain. Ann Neurol 34(4):609\u2013616","journal-title":"Ann Neurol"},{"key":"3763_CR71","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.595532","volume":"11","author":"C Alquezar","year":"2021","unstructured":"Alquezar C, Arya S, Kao AW (2021) Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation. Front Neurol 11:595532","journal-title":"Front Neurol"},{"key":"3763_CR72","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1159\/000362239","volume":"14","author":"C-E Zhang","year":"2014","unstructured":"Zhang C-E et al (2014) Hypoxia-induced tau phosphorylation and memory deficit in rats. Neurodegener Dis 14:107\u2013116","journal-title":"Neurodegener Dis"},{"issue":"2","key":"3763_CR73","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1046\/j.1471-4159.1995.65020732.x","volume":"65","author":"C-X Gong","year":"1995","unstructured":"Gong C-X et al (1995) Phosphatase activity toward abnormally phosphorylated \u03c4: decrease in Alzheimer disease brain. J Neurochem 65(2):732\u2013738","journal-title":"J Neurochem"},{"key":"3763_CR74","doi-asserted-by":"publisher","first-page":"5103","DOI":"10.1007\/s12035-020-02084-0","volume":"57","author":"S Guha","year":"2020","unstructured":"Guha S, Johnson GV, Nehrke K (2020) The crosstalk between pathological tau phosphorylation and mitochondrial dysfunction as a key to understanding and treating Alzheimer\u2019s disease. Mol Neurobiol 57:5103\u20135120","journal-title":"Mol Neurobiol"},{"issue":"7","key":"3763_CR75","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","volume":"21","author":"H Sies","year":"2020","unstructured":"Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21(7):363\u2013383","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"9","key":"3763_CR76","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1089\/ars.2015.6247","volume":"23","author":"DP Jones","year":"2015","unstructured":"Jones DP, Sies H (2015) The redox code. Antioxid Redox Signal 23(9):734\u2013746","journal-title":"Antioxid Redox Signal"},{"key":"3763_CR77","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.redox.2013.12.011","volume":"2","author":"RJ Mailloux","year":"2014","unstructured":"Mailloux RJ, Jin X, Willmore WG (2014) Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions. Redox Biol 2:123\u2013139","journal-title":"Redox Biol"},{"issue":"7","key":"3763_CR78","first-page":"1099","volume":"1837","author":"I Mart\u00ednez-Reyes","year":"2014","unstructured":"Mart\u00ednez-Reyes I, Cuezva JM (2014) The H(+)-ATP synthase: a gate to ROS-mediated cell death or cell survival. Biochem Biophys Acta 1837(7):1099\u20131112","journal-title":"Biochem Biophys Acta"},{"issue":"53","key":"3763_CR79","doi-asserted-by":"publisher","first-page":"pe1","DOI":"10.1126\/stke.2000.53.pe1","volume":"2000","author":"SG Rhee","year":"2000","unstructured":"Rhee SG et al (2000) Hydrogen peroxide: a key messenger that modulates protein phosphorylation through cysteine oxidation. Sci STKE 2000(53):pe1","journal-title":"Sci STKE"},{"issue":"5","key":"3763_CR80","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.cell.2005.05.016","volume":"121","author":"NK Tonks","year":"2005","unstructured":"Tonks NK (2005) Redox redux: revisiting PTPs and the control of cell signaling. Cell 121(5):667\u2013670","journal-title":"Cell"},{"issue":"s1","key":"3763_CR81","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1601-183X.2007.00376.x","volume":"7","author":"D Muyllaert","year":"2008","unstructured":"Muyllaert D et al (2008) Glycogen synthase kinase-3\u03b2, or a link between amyloid and tau pathology? Genes Brain Behav 7(s1):57\u201366","journal-title":"Genes Brain Behav"},{"key":"3763_CR82","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fncel.2020.00019","volume":"14","author":"D Toral-Rios","year":"2020","unstructured":"Toral-Rios D et al (2020) GSK3\u03b2 and tau protein in Alzheimer\u2019s disease and epilepsy. Front Cell Neurosci 14:19","journal-title":"Front Cell Neurosci"},{"issue":"2","key":"3763_CR83","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.bbadis.2015.12.002","volume":"1862","author":"K Liu","year":"2016","unstructured":"Liu K et al (2016) Glycation alter the process of tau phosphorylation to change tau isoforms aggregation property. Biochimica et Biophysica Acta (BBA) - Mol Basis Dis 1862(2):192\u2013201","journal-title":"Biochimica et Biophysica Acta (BBA) - Mol Basis Dis"},{"key":"3763_CR84","first-page":"e51537","volume":"95","author":"D Sui","year":"2015","unstructured":"Sui D, Liu M, Kuo M-H (2015) In vitro aggregation assays using hyperphosphorylated tau protein. JoVE 95:e51537","journal-title":"JoVE"},{"key":"3763_CR85","first-page":"337","volume-title":"Methods in enzymology","author":"BA Hemmings","year":"1983","unstructured":"Hemmings BA, Cohen P (1983) [36] Glycogen synthase kinase-3 from rabbit skeletal muscle. Methods in enzymology. Academic Press, pp 337\u2013345"},{"issue":"1","key":"3763_CR86","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1152\/jappl.1995.79.1.136","volume":"79","author":"SI Harik","year":"1995","unstructured":"Harik SI et al (1995) Brain glucose metabolism in hypobaric hypoxia. J Appl Physiol 79(1):136\u2013140","journal-title":"J Appl Physiol"},{"issue":"1","key":"3763_CR87","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1093\/toxsci\/kfn266","volume":"108","author":"SH Wang","year":"2009","unstructured":"Wang SH et al (2009) Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells. Toxicol Sci 108(1):124\u2013131","journal-title":"Toxicol Sci"},{"issue":"3\u20134","key":"3763_CR88","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.ijdevneu.2008.02.002","volume":"26","author":"JG Pizarro","year":"2008","unstructured":"Pizarro JG et al (2008) Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. Int J Dev Neurosci 26(3\u20134):269\u2013276","journal-title":"Int J Dev Neurosci"},{"issue":"1","key":"3763_CR89","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.neuropharm.2004.09.014","volume":"48","author":"NB Chauhan","year":"2005","unstructured":"Chauhan NB, Siegel GJ, Feinstein DL (2005) Propentofylline attenuates tau hyperphosphorylation in Alzheimer\u2019s Swedish mutant model Tg2576. Neuropharmacology 48(1):93\u2013104","journal-title":"Neuropharmacology"},{"issue":"4","key":"3763_CR90","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1002\/jcb.10391","volume":"88","author":"P Strocchi","year":"2003","unstructured":"Strocchi P, Pession A, Dozza B (2003) Up-regulation of cDK5\/p35 by oxidative stress in human neuroblastoma IMR-32 cells. J Cell Biochem 88(4):758\u2013765","journal-title":"J Cell Biochem"},{"issue":"6","key":"3763_CR91","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1002\/jnr.20099","volume":"76","author":"TB Shea","year":"2004","unstructured":"Shea TB et al (2004) Cyclin-dependent kinase 5 increases perikaryal neurofilament phosphorylation and inhibits neurofilament axonal transport in response to oxidative stress. J Neurosci Res 76(6):795\u2013800","journal-title":"J Neurosci Res"},{"issue":"3","key":"3763_CR92","doi-asserted-by":"publisher","first-page":"289","DOI":"10.4161\/cc.3.3.706","volume":"3","author":"PD Smith","year":"2004","unstructured":"Smith PD, O\u2019Hare MJ, Park DS (2004) Emerging pathogenic role for cyclin dependent kinases in neurodegeneration. Cell Cycle 3(3):289\u2013291","journal-title":"Cell Cycle"},{"issue":"6762","key":"3763_CR93","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1038\/45159","volume":"402","author":"GN Patrick","year":"1999","unstructured":"Patrick GN et al (1999) Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration. Nature 402(6762):615\u2013622","journal-title":"Nature"},{"issue":"3","key":"3763_CR94","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1111\/j.1471-4159.1993.tb03603.x","volume":"61","author":"C-X Gong","year":"1993","unstructured":"Gong C-X et al (1993) Phosphoprotein phosphatase activities in Alzheimer disease brain. J Neurochem 61(3):921\u2013927","journal-title":"J Neurochem"},{"issue":"1","key":"3763_CR95","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1111\/j.1582-4934.2008.00249.x","volume":"12","author":"R Liu","year":"2008","unstructured":"Liu R et al (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12(1):241\u2013257","journal-title":"J Cell Mol Med"},{"issue":"12","key":"3763_CR96","doi-asserted-by":"publisher","first-page":"1094","DOI":"10.18632\/aging.100853","volume":"7","author":"AMM Orellana","year":"2015","unstructured":"Orellana AMM et al (2015) Age-related neuroinflammation and changes in AKT-GSK-3\u03b2 and WNT\/\u03b2-catenin signaling in rat hippocampus. Aging 7(12):1094\u20131111","journal-title":"Aging"},{"issue":"1","key":"3763_CR97","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/S0168-0102(99)00026-7","volume":"34","author":"K-Y Lee","year":"1999","unstructured":"Lee K-Y et al (1999) Elevated neuronal Cdc2-like kinase activity in the Alzheimer disease brain. Neurosci Res 34(1):21\u201329","journal-title":"Neurosci Res"},{"issue":"6","key":"3763_CR98","doi-asserted-by":"publisher","first-page":"2256","DOI":"10.1111\/j.1471-4159.2007.04930.x","volume":"103","author":"I Kelleher","year":"2007","unstructured":"Kelleher I et al (2007) Kinase activities increase during the development of tauopathy in htau mice. J Neurochem 103(6):2256\u20132267","journal-title":"J Neurochem"},{"issue":"43","key":"3763_CR99","doi-asserted-by":"publisher","first-page":"33435","DOI":"10.1074\/jbc.M110.149419","volume":"285","author":"A Leroy","year":"2010","unstructured":"Leroy A et al (2010) Spectroscopic studies of GSK3\u03b2 phosphorylation of the neuronal tau protein and its interaction with the N-terminal domain of apolipoprotein E. J Biol Chem 285(43):33435\u201333444","journal-title":"J Biol Chem"},{"issue":"31","key":"3763_CR100","doi-asserted-by":"publisher","first-page":"23512","DOI":"10.1016\/S0021-9258(19)49492-1","volume":"268","author":"HK Paudel","year":"1993","unstructured":"Paudel HK et al (1993) Brain proline-directed protein kinase phosphorylates tau on sites that are abnormally phosphorylated in tau associated with Alzheimer\u2019s paired helical filaments. J Biol Chem 268(31):23512\u201323518","journal-title":"J Biol Chem"},{"issue":"1","key":"3763_CR101","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40478-017-0501-1","volume":"6","author":"M Uematsu","year":"2018","unstructured":"Uematsu M et al (2018) Brainstem tau pathology in Alzheimer\u2019s disease is characterized by increase of three repeat tau and independent of amyloid \u03b2. Acta Neuropathol Commun 6(1):1","journal-title":"Acta Neuropathol Commun"},{"issue":"4","key":"3763_CR102","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s10522-008-9189-8","volume":"10","author":"MS Wai","year":"2009","unstructured":"Wai MS et al (2009) Co-localization of hyperphosphorylated tau and caspases in the brainstem of Alzheimer\u2019s disease patients. Biogerontology 10(4):457\u2013469","journal-title":"Biogerontology"},{"key":"3763_CR103","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archneur.1962.04210030065009","volume":"7","author":"A Hirano","year":"1962","unstructured":"Hirano A, Zimmerman HM (1962) Alzheimer\u2019s neurofibrillary changes. A topographic study. Arch Neurol 7:227\u2013242","journal-title":"Arch Neurol"},{"issue":"2","key":"3763_CR104","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1007\/BF00686763","volume":"6","author":"T Ishii","year":"1966","unstructured":"Ishii T (1966) Distribution of Alzheimer\u2019s neurofibrillary changes in the brain stem and hypothalamus of senile dementia. Acta Neuropathol 6(2):181\u2013187","journal-title":"Acta Neuropathol"},{"key":"3763_CR105","doi-asserted-by":"publisher","first-page":"529","DOI":"10.3389\/fnins.2019.00529","volume":"13","author":"K Zhu","year":"2019","unstructured":"Zhu K et al (2019) Primary age-related tauopathy in human subcortical nuclei. Front Neurosci 13:529","journal-title":"Front Neurosci"},{"issue":"6","key":"3763_CR106","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1046\/j.1471-4159.2003.02070.x","volume":"87","author":"SJ Liu","year":"2003","unstructured":"Liu SJ et al (2003) Overactivation of glycogen synthase kinase-3 by inhibition of phosphoinositol-3 kinase and protein kinase C leads to hyperphosphorylation of tau and impairment of spatial memory. J Neurochem 87(6):1333\u20131344","journal-title":"J Neurochem"},{"issue":"1","key":"3763_CR107","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","volume":"33","author":"L Bu\u00e9e","year":"2000","unstructured":"Bu\u00e9e L et al (2000) Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res Rev 33(1):95\u2013130","journal-title":"Brain Res Rev"},{"issue":"1","key":"3763_CR108","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/s13024-022-00533-z","volume":"17","author":"Y Zhang","year":"2022","unstructured":"Zhang Y et al (2022) Tauopathies: new perspectives and challenges. Mol Neurodegener 17(1):28","journal-title":"Mol Neurodegener"},{"issue":"6","key":"3763_CR109","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","volume":"68","author":"BR Hoover","year":"2010","unstructured":"Hoover BR et al (2010) Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 68(6):1067\u20131081","journal-title":"Neuron"},{"issue":"3","key":"3763_CR110","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.neuron.2007.01.010","volume":"53","author":"Y Yoshiyama","year":"2007","unstructured":"Yoshiyama Y et al (2007) Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53(3):337\u2013351","journal-title":"Neuron"},{"key":"3763_CR111","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40035-021-00270-1","volume":"10","author":"M Wu","year":"2021","unstructured":"Wu M et al (2021) The role of pathological tau in synaptic dysfunction in Alzheimer\u2019s diseases. Transl Neurodegen 10:1\u201311","journal-title":"Transl Neurodegen"},{"issue":"1","key":"3763_CR112","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1186\/s13195-020-00651-0","volume":"12","author":"CM Holton","year":"2020","unstructured":"Holton CM et al (2020) Longitudinal changes in EEG power, sleep cycles and behaviour in a tau model of neurodegeneration. Alzheimers Res Ther 12(1):84","journal-title":"Alzheimers Res Ther"},{"issue":"1","key":"3763_CR113","doi-asserted-by":"publisher","first-page":"7797","DOI":"10.1038\/s41598-021-86255-6","volume":"11","author":"JR Scarpa","year":"2021","unstructured":"Scarpa JR et al (2021) NREM delta power and AD-relevant tauopathy are associated with shared cortical gene networks. Sci Rep 11(1):7797","journal-title":"Sci Rep"},{"key":"3763_CR114","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1002\/acn3.390","volume":"4","author":"JK Holth","year":"2017","unstructured":"Holth JK et al (2017) Altered sleep and EEG power in the P301S tau transgenic mouse model. Ann Clin Transl Neurol 4:180\u2013190. https:\/\/doi.org\/10.1002\/acn3.390","journal-title":"Ann Clin Transl Neurol"},{"issue":"15","key":"3763_CR115","doi-asserted-by":"publisher","first-page":"5431","DOI":"10.3390\/ijms21155431","volume":"21","author":"A Ahnaou","year":"2020","unstructured":"Ahnaou A et al (2020) Functional alterations in the olfactory neuronal circuit occur before hippocampal plasticity deficits in the P301S mouse model of tauopathy: implications for early diagnosis and translational research in Alzheimer\u2019s disease. Int J Mol Sci 21(15):5431","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3763_CR116","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nrn3241","volume":"13","author":"G Buzs\u00e1ki","year":"2012","unstructured":"Buzs\u00e1ki G, Anastassiou CA, Koch C (2012) The origin of extracellular fields and currents\u2014EEG, ECoG, LFP and spikes. Nat Rev Neurosci 13(6):407\u2013420","journal-title":"Nat Rev Neurosci"},{"issue":"3","key":"3763_CR117","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1016\/S0168-5597(97)96139-6","volume":"104","author":"J Polich","year":"1997","unstructured":"Polich J (1997) EEG and ERP assessment of normal aging. Electroencephal Clin Neurophysiol\/Evoked Potent Sect 104(3):244\u2013256","journal-title":"Electroencephal Clin Neurophysiol\/Evoked Potent Sect"},{"issue":"5","key":"3763_CR118","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1097\/ALN.0000000000003182","volume":"132","author":"M Kreuzer","year":"2020","unstructured":"Kreuzer M et al (2020) Spectral and entropic features are altered by age in the electroencephalogram in patients under sevoflurane anesthesia. Anesthesiology 132(5):1003\u20131016","journal-title":"Anesthesiology"},{"issue":"2","key":"3763_CR119","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1002\/hbm.20175","volume":"27","author":"C Babiloni","year":"2006","unstructured":"Babiloni C et al (2006) Sources of cortical rhythms in adults during physiological aging: a multicentric EEG study. Hum Brain Mapp 27(2):162\u2013172","journal-title":"Hum Brain Mapp"},{"issue":"10","key":"3763_CR120","doi-asserted-by":"publisher","first-page":"2768","DOI":"10.1016\/j.neurobiolaging.2015.07.001","volume":"36","author":"A Jyoti","year":"2015","unstructured":"Jyoti A et al (2015) Progressive age-related changes in sleep and EEG profiles in the PLB1Triple mouse model of Alzheimer\u2019s disease. Neurobiol Aging 36(10):2768\u20132784","journal-title":"Neurobiol Aging"},{"issue":"1","key":"3763_CR121","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/BF03323891","volume":"2","author":"LF Agnati","year":"1990","unstructured":"Agnati LF et al (1990) Cellular and synaptic alterations in the aging brain. Aging Clin Exp Res 2(1):5\u201325","journal-title":"Aging Clin Exp Res"},{"issue":"9","key":"3763_CR122","doi-asserted-by":"publisher","first-page":"4094","DOI":"10.1523\/JNEUROSCI.4825-12.2013","volume":"33","author":"R Mostany","year":"2013","unstructured":"Mostany R et al (2013) Altered synaptic dynamics during normal brain aging. J Neurosci 33(9):4094","journal-title":"J Neurosci"},{"issue":"4","key":"3763_CR123","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1159\/000486870","volume":"75","author":"R Ishii","year":"2017","unstructured":"Ishii R et al (2017) Healthy and pathological brain aging: from the perspective of oscillations, functional connectivity, and signal complexity. Neuropsychobiology 75(4):151\u2013161","journal-title":"Neuropsychobiology"},{"issue":"2","key":"3763_CR124","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/0301-0082(91)90024-U","volume":"37","author":"R Monteau","year":"1991","unstructured":"Monteau R, Hilaire G (1991) Spinal respiratory motoneurons. Prog Neurobiol 37(2):83\u2013144","journal-title":"Prog Neurobiol"},{"issue":"1","key":"3763_CR125","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1113\/jphysiol.2006.108753","volume":"575","author":"MP Walsh","year":"2006","unstructured":"Walsh MP, Marshall JM (2006) The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide. J Physiol 575(1):263\u2013275","journal-title":"J Physiol"},{"issue":"9","key":"3763_CR126","doi-asserted-by":"publisher","first-page":"1008","DOI":"10.1113\/EP085237","volume":"100","author":"RR Perim","year":"2015","unstructured":"Perim RR, Bonagamba LGH, Machado BH (2015) Cardiovascular and respiratory outcome of preconditioned rats submitted to chronic intermittent hypoxia. Exp Physiol 100(9):1008\u20131017","journal-title":"Exp Physiol"},{"issue":"3","key":"3763_CR127","doi-asserted-by":"publisher","first-page":"R658","DOI":"10.1152\/ajpregu.1999.277.3.R658","volume":"277","author":"R Kinkead","year":"1999","unstructured":"Kinkead R, Mitchell GS (1999) Time-dependent hypoxic ventilatory responses in rats: effects of ketanserin and 5-carboxamidotryptamine. Am J Physiol-Regul Integr Comp Physiol 277(3):R658\u2013R666","journal-title":"Am J Physiol-Regul Integr Comp Physiol"},{"issue":"4","key":"3763_CR128","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.1152\/jappl.1993.74.4.1635","volume":"74","author":"EA Aaron","year":"1993","unstructured":"Aaron EA, Powell FL (1993) Effect of chronic hypoxia on hypoxic ventilatory response in awake rats. J Appl Physiol 74(4):1635\u20131640","journal-title":"J Appl Physiol"},{"issue":"7","key":"3763_CR129","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1152\/japplphysiol.01126.2013","volume":"116","author":"JA Dempsey","year":"2014","unstructured":"Dempsey JA et al (2014) Role of chemoreception in cardiorespiratory acclimatization to, and deacclimatization from, hypoxia. J Appl Physiol (1985) 116(7):858\u201366","journal-title":"J Appl Physiol (1985)"},{"issue":"6","key":"3763_CR130","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1152\/jappl.1976.41.6.878","volume":"41","author":"HV Forster","year":"1976","unstructured":"Forster HV et al (1976) Ventilatory control in peripheral chemoreceptor-denervated ponies during chronic hypoxemia. J Appl Physiol 41(6):878\u2013885","journal-title":"J Appl Physiol"},{"issue":"3","key":"3763_CR131","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1016\/0034-5687(74)90034-6","volume":"20","author":"HV Forster","year":"1974","unstructured":"Forster HV et al (1974) Evidence of altered regulation of ventilation during exposure to hypoxia. Respir Physiol 20(3):379\u2013392","journal-title":"Respir Physiol"},{"issue":"2","key":"3763_CR132","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1152\/japplphysiol.01311.2009","volume":"109","author":"KA Wilkinson","year":"2010","unstructured":"Wilkinson KA et al (2010) Chronic hypoxia increases the gain of the hypoxic ventilatory response by a mechanism in the central nervous system. J Appl Physiol (1985) 109(2):424\u201330","journal-title":"J Appl Physiol (1985)"},{"issue":"1","key":"3763_CR133","doi-asserted-by":"publisher","first-page":"57","DOI":"10.3233\/JAD-2005-8107","volume":"8","author":"J Attems","year":"2005","unstructured":"Attems J et al (2005) Cause of death in demented and non-demented elderly inpatients; an autopsy study of 308 cases. J Alzheimers Dis 8(1):57\u201362","journal-title":"J Alzheimers Dis"},{"issue":"1\u20132","key":"3763_CR134","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.resp.2009.04.017","volume":"168","author":"DM Katz","year":"2009","unstructured":"Katz DM et al (2009) Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth. Respir Physiol Neurobiol 168(1\u20132):101\u2013108","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"3763_CR135","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.nbd.2012.01.012","volume":"46","author":"C Menuet","year":"2012","unstructured":"Menuet C et al (2012) Isoflurane anesthesia precipitates tauopathy and upper airways dysfunction in pre-symptomatic Tau.P301L mice: possible implication for neurodegenerative diseases. Neurobiol Dis 46(1):234\u201343","journal-title":"Neurobiol Dis"},{"issue":"2","key":"3763_CR136","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.resp.2011.06.030","volume":"178","author":"C Menuet","year":"2011","unstructured":"Menuet C et al (2011) Raph\u00e9 tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer\u2019s disease. Respir Physiol Neurobiol 178(2):290\u2013303","journal-title":"Respir Physiol Neurobiol"},{"issue":"5","key":"3763_CR137","doi-asserted-by":"publisher","first-page":"3963","DOI":"10.1074\/jbc.M409876200","volume":"280","author":"D Terwel","year":"2005","unstructured":"Terwel D et al (2005) Changed conformation of mutant tau-P301L underlies the moribund tauopathy, absent in progressive, nonlethal axonopathy of tau-4R\/2N transgenic mice. J Biol Chem 280(5):3963\u20133973","journal-title":"J Biol Chem"},{"issue":"1","key":"3763_CR138","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.resp.2004.11.005","volume":"146","author":"M Wu","year":"2005","unstructured":"Wu M, Haxhiu MA, Johnson SM (2005) Hypercapnic and hypoxic responses require intact neural transmission from the pre-B\u00f6tzinger complex. Respir Physiol Neurobiol 146(1):33\u201346","journal-title":"Respir Physiol Neurobiol"},{"issue":"1","key":"3763_CR139","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1002\/neu.480120107","volume":"12","author":"G Baux","year":"1981","unstructured":"Baux G, Simonneau M, Tauc L (1981) Action of colchicine on membrane currents and synaptic transmission in Aplysia ganglion cells. J Neurobiol 12(1):75\u201385","journal-title":"J Neurobiol"},{"issue":"9","key":"3763_CR140","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.1007\/BF01946735","volume":"29","author":"AL Donoso","year":"1973","unstructured":"Donoso AL, Fernandez HL (1973) Effect of colchicine on long lasting synaptic modifications induced by hyperactivity. Experientia 29(9):1089\u20131090","journal-title":"Experientia"},{"issue":"3","key":"3763_CR141","doi-asserted-by":"publisher","first-page":"253","DOI":"10.2147\/ciia.2006.1.3.253","volume":"1","author":"G Sharma","year":"2006","unstructured":"Sharma G, Goodwin J (2006) Effect of aging on respiratory system physiology and immunology. Clin Interv Aging 1(3):253\u2013260","journal-title":"Clin Interv Aging"},{"issue":"1","key":"3763_CR142","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0749-0690(18)30963-7","volume":"1","author":"PE Krumpe","year":"1985","unstructured":"Krumpe PE et al (1985) The aging respiratory system. Clin Geriatr Med 1(1):143\u2013175","journal-title":"Clin Geriatr Med"},{"issue":"12","key":"3763_CR143","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1007\/BF03021586","volume":"53","author":"J Sprung","year":"2006","unstructured":"Sprung J, Gajic O, Warner DO (2006) Review article: age related alterations in respiratory function - anesthetic considerations. Can J Anaesth 53(12):1244\u20131257","journal-title":"Can J Anaesth"},{"issue":"6843","key":"3763_CR144","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1038\/35084005","volume":"412","author":"NK Logothetis","year":"2001","unstructured":"Logothetis NK et al (2001) Neurophysiological investigation of the basis of the fMRI signal. Nature 412(6843):150\u2013157","journal-title":"Nature"},{"issue":"11","key":"3763_CR145","doi-asserted-by":"publisher","first-page":"1219","DOI":"10.1093\/cercor\/bhg104","volume":"13","author":"DA McCormick","year":"2003","unstructured":"McCormick DA et al (2003) Persistent cortical activity: mechanisms of generation and effects on neuronal excitability. Cereb Cortex 13(11):1219\u20131231","journal-title":"Cereb Cortex"},{"issue":"2","key":"3763_CR146","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1046\/j.1460-9568.1998.00096.x","volume":"10","author":"M Penttonen","year":"1998","unstructured":"Penttonen M et al (1998) Gamma frequency oscillation in the hippocampus of the rat: intracellular analysis in vivo. Eur J Neurosci 10(2):718\u2013728","journal-title":"Eur J Neurosci"},{"issue":"6","key":"3763_CR147","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/75797","volume":"3","author":"J Anderson","year":"2000","unstructured":"Anderson J et al (2000) Stimulus dependence of two-state fluctuations of membrane potential in cat visual cortex. Nat Neurosci 3(6):617\u2013621","journal-title":"Nat Neurosci"},{"key":"3763_CR148","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1146\/annurev.physiol.66.082602.092845","volume":"66","author":"NK Logothetis","year":"2004","unstructured":"Logothetis NK, Wandell BA (2004) Interpreting the BOLD signal. Annu Rev Physiol 66:735\u2013769","journal-title":"Annu Rev Physiol"},{"issue":"1","key":"3763_CR149","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1152\/jn.00919.2004","volume":"94","author":"JA Henrie","year":"2005","unstructured":"Henrie JA, Shapley R (2005) LFP power spectra in V1 cortex: the graded effect of stimulus contrast. J Neurophysiol 94(1):479\u2013490","journal-title":"J Neurophysiol"},{"key":"3763_CR150","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","volume":"35","author":"G Buzs\u00e1ki","year":"2012","unstructured":"Buzs\u00e1ki G, Wang XJ (2012) Mechanisms of gamma oscillations. Annu Rev Neurosci 35:203\u2013225","journal-title":"Annu Rev Neurosci"},{"issue":"3","key":"3763_CR151","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1152\/jn.1991.66.3.1059","volume":"66","author":"WW Lytton","year":"1991","unstructured":"Lytton WW, Sejnowski TJ (1991) Simulations of cortical pyramidal neurons synchronized by inhibitory interneurons. J Neurophysiol 66(3):1059\u20131079","journal-title":"J Neurophysiol"},{"issue":"6213","key":"3763_CR152","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1038\/338334a0","volume":"338","author":"CM Gray","year":"1989","unstructured":"Gray CM et al (1989) Oscillatory responses in cat visual cortex exhibit inter-columnar synchronization which reflects global stimulus properties. Nature 338(6213):334\u2013337","journal-title":"Nature"},{"issue":"1","key":"3763_CR153","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0301-0082(99)00029-5","volume":"60","author":"P Brown","year":"2000","unstructured":"Brown P (2000) Cortical drives to human muscle: the Piper and related rhythms. Prog Neurobiol 60(1):97\u2013108","journal-title":"Prog Neurobiol"},{"key":"3763_CR154","doi-asserted-by":"crossref","unstructured":"Engelhard B, Vaadia E (2014) Spatial computation with gamma oscillations. Front Syst Neurosci 8","DOI":"10.3389\/fnsys.2014.00165"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03763-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03763-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03763-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T05:26:04Z","timestamp":1715318764000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03763-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,17]]},"references-count":154,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["3763"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03763-4","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.742857089.793601603","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,17]]},"assertion":[{"value":"23 November 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 October 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 November 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures and handling techniques were approved by the Ethical Committee for Animal Research of Tabriz University of Medical Sciences (IR.TBZMED.VCR.REC.1399.404), and surgical procedures were conducted under aseptic conditions.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}