{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T09:33:10Z","timestamp":1770715990860,"version":"3.49.0"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T00:00:00Z","timestamp":1704240000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171369"],"award-info":[{"award-number":["82171369"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102107"],"award-info":[{"award-number":["82102107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012829","name":"Guangdong Provincial Hospital of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["JZ2020KF02"],"award-info":[{"award-number":["JZ2020KF02"]}],"id":[{"id":"10.13039\/100012829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110189"],"award-info":[{"award-number":["2022A1515110189"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012165"],"award-info":[{"award-number":["2021A1515012165"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s12035-023-03887-7","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T13:02:17Z","timestamp":1704286937000},"page":"5194-5205","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brachial Plexus Root Avulsion Injury-Induced Endothelin-Converting Enzyme-Like 1 Overexpression Is Associated with Injured Motor Neurons Survival"],"prefix":"10.1007","volume":"61","author":[{"given":"Yu","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunlin","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijian","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqin","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingying","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingzhen","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingqin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3664-9234","authenticated-orcid":false,"given":"Ke","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,3]]},"reference":[{"issue":"2","key":"3887_CR1","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/0304-3940(93)90303-3","volume":"153","author":"W Wu","year":"1993","unstructured":"Wu W, Li L (1993) Inhibition of nitric oxide synthase reduces motoneuron death due to spinal root avulsion. Neurosci Lett 153(2):121\u2013124. https:\/\/doi.org\/10.1016\/0304-3940(93)90303-3","journal-title":"Neurosci Lett"},{"issue":"1","key":"3887_CR2","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1186\/s12974-022-02632-6","volume":"19","author":"K Zhong","year":"2022","unstructured":"Zhong K, Huang Y, Zilundu PLM, Wang Y, Zhou Y, Yu G, Fu R, Chung SK et al (2022) Motor neuron survival is associated with reduced neuroinflammation and increased autophagy after brachial plexus avulsion injury in aldose reductase-deficient mice. J Neuroinflammation 19(1):271\u2013291. https:\/\/doi.org\/10.1186\/s12974-022-02632-6","journal-title":"J Neuroinflammation"},{"issue":"2","key":"3887_CR3","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.expneurol.2004.05.014","volume":"189","author":"B Blits","year":"2004","unstructured":"Blits B, Carlstedt TP, Ruitenberg MJ, de Winter F, Hermens WT, Dijkhuizen PA, Claasens JW, Eggers R et al (2004) Rescue and sprouting of motoneurons following ventral root avulsion and reimplantation combined with intraspinal adeno-associated viral vector-mediated expression of glial cell line-derived neurotrophic factor or brain-derived neurotrophic factor. Exp Neurol 189(2):303\u2013316. https:\/\/doi.org\/10.1016\/j.expneurol.2004.05.014","journal-title":"Exp Neurol"},{"issue":"2","key":"3887_CR4","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1002\/stem.1873","volume":"33","author":"E Ben-Shushan","year":"2015","unstructured":"Ben-Shushan E, Feldman E, Reubinoff BE (2015) Notch signaling regulates motor neuron differentiation of human embryonic stem cells. Stem Cells 33(2):403\u2013415. https:\/\/doi.org\/10.1002\/stem.1873","journal-title":"Stem Cells"},{"issue":"3","key":"3887_CR5","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00221-001-0929-0","volume":"142","author":"A McKay Hart","year":"2002","unstructured":"McKay Hart A, Brannstrom T, Wiberg M, Terenghi G (2002) Primary sensory neurons and satellite cells after peripheral axotomy in the adult rat: timecourse of cell death and elimination. Exp Brain Res 142(3):308\u2013318. https:\/\/doi.org\/10.1007\/s00221-001-0929-0","journal-title":"Exp Brain Res"},{"key":"3887_CR6","doi-asserted-by":"publisher","first-page":"105281","DOI":"10.1016\/j.phrs.2020.105281","volume":"162","author":"C Miranda-Louren\u00e7o","year":"2020","unstructured":"Miranda-Louren\u00e7o C, Ribeiro-Rodrigues L, Fonseca-Gomes J, Tanqueiro SR, Belo RF, Ferreira CB, Rei N, Ferreira-Manso M et al (2020) Challenges of BDNF-based therapies: from common to rare diseases. Pharmacol Res 162:105281. https:\/\/doi.org\/10.1016\/j.phrs.2020.105281","journal-title":"Pharmacol Res"},{"issue":"6","key":"3887_CR7","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1007\/s11064-018-2665-x","volume":"44","author":"S Kiryu-Seo","year":"2019","unstructured":"Kiryu-Seo S, Nagata K, Saido TC, Kiyama H (2019) New insights of a neuronal peptidase DINE\/ECEL1: nerve development, nerve regeneration and neurogenic pathogenesis. Neurochem Res 44(6):1279\u20131288. https:\/\/doi.org\/10.1007\/s11064-018-2665-x","journal-title":"Neurochem Res"},{"issue":"Pt 3","key":"3887_CR8","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1042\/bj3460611","volume":"346","author":"O Valdenaire","year":"2000","unstructured":"Valdenaire O, Rohrbacher E, Langeveld A, Schweizer A, Meijers C (2000) Organization and chromosomal localization of the human ECEL1 (XCE) gene encoding a zinc metallopeptidase involved in the nervous control of respiration. Biochem J 346(Pt 3):611\u2013616","journal-title":"Biochem J"},{"issue":"1","key":"3887_CR9","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neuroscience.2006.03.032","volume":"141","author":"K Nagata","year":"2006","unstructured":"Nagata K, Kiryu-Seo S, Kiyama H (2006) Localization and ontogeny of damage-induced neuronal endopeptidase mRNA-expressing neurons in the rat nervous system. Neuroscience 141(1):299\u2013310. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.03.032","journal-title":"Neuroscience"},{"issue":"21","key":"3887_CR10","doi-asserted-by":"publisher","first-page":"9410","DOI":"10.1523\/jneurosci.22-21-09410.2002","volume":"22","author":"R Kato","year":"2002","unstructured":"Kato R, Kiryu-Seo S, Kiyama H (2002) Damage-induced neuronal endopeptidase (DINE\/ECEL) expression is regulated by leukemia inhibitory factor and deprivation of nerve growth factor in rat sensory ganglia after nerve injury. J Neurosci 22(21):9410\u20139418. https:\/\/doi.org\/10.1523\/jneurosci.22-21-09410.2002","journal-title":"J Neurosci"},{"key":"3887_CR11","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.biopha.2018.04.116","volume":"103","author":"Q Sang","year":"2018","unstructured":"Sang Q, Sun D, Chen Z, Zhao W (2018) NGF and PI3K\/Akt signaling participate in the ventral motor neuronal protection of curcumin in sciatic nerve injury rat models. Biomed Pharmacother 103:1146\u20131153. https:\/\/doi.org\/10.1016\/j.biopha.2018.04.116","journal-title":"Biomed Pharmacother"},{"issue":"23","key":"3887_CR12","doi-asserted-by":"publisher","first-page":"1786","DOI":"10.3969\/j.issn.1673-5374.2012.23.004","volume":"7","author":"B Wang","year":"2012","unstructured":"Wang B, Chen L, Liu B, Liu Z, Zhang Z, Pan Y, Song L, Lu L (2012) Differentiation of endogenous neural stem cells in adult versus neonatal rats after brachial plexus root avulsion injury. Neural Regen Res 7(23):1786\u20131790. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2012.23.004","journal-title":"Neural Regen Res"},{"issue":"11","key":"3887_CR13","doi-asserted-by":"publisher","first-page":"6988","DOI":"10.1074\/jbc.m707514200","volume":"283","author":"S Kiryu-Seo","year":"2008","unstructured":"Kiryu-Seo S, Kato R, Ogawa T, Nakagomi S, Nagata K, Kiyama H (2008) Neuronal injury-inducible gene is synergistically regulated by ATF3, c-Jun, and STAT3 through the interaction with Sp1 in damaged neurons. J Biol Chem 283(11):6988\u20136996. https:\/\/doi.org\/10.1074\/jbc.m707514200","journal-title":"J Biol Chem"},{"issue":"2","key":"3887_CR14","doi-asserted-by":"publisher","first-page":"30","DOI":"10.3389\/fneur.2011.00030","volume":"5","author":"H Lind\u00e5","year":"2011","unstructured":"Lind\u00e5 H, Sk\u00f6ld MK, Ochsmann T (2011) Activating transcription factor 3, a useful marker for regenerative response after nerve root injury. Front Neurol 5(2):30. https:\/\/doi.org\/10.3389\/fneur.2011.00030","journal-title":"Front Neurol"},{"issue":"12","key":"3887_CR15","doi-asserted-by":"publisher","first-page":"5187","DOI":"10.1523\/jneurosci.23-12-05187.2003","volume":"23","author":"S Nakagomi","year":"2003","unstructured":"Nakagomi S, Suzuki Y, Namikawa K, Kiryu-Seo S, Kiyama H (2003) Expression of the activating transcription factor 3 prevents c-Jun N-terminal kinase-induced neuronal death by promoting heat shock protein 27 expression and Akt activation. J Neurosci 23(12):5187\u20135196. https:\/\/doi.org\/10.1523\/jneurosci.23-12-05187.2003","journal-title":"J Neurosci"},{"issue":"8","key":"3887_CR16","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1111\/j.1460-9568.2005.04389.x","volume":"22","author":"AS Vlug","year":"2005","unstructured":"Vlug AS, Teuling E, Haasdijk ED, French P, Hoogenraad CC, Jaarsma D (2005) ATF3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis-SOD1 transgenic mice and correlates with c-Jun phosphorylation, CHOP expression, somato-dendritic ubiquitination and Golgi fragmentation. Eur J Neurosci 22(8):1881\u20131894. https:\/\/doi.org\/10.1111\/j.1460-9568.2005.04389.x","journal-title":"Eur J Neurosci"},{"issue":"1\u20132","key":"3887_CR17","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/j.mcn.2006.03.005","volume":"32","author":"R Seijffers","year":"2006","unstructured":"Seijffers R, Allchorne AJ, Woolf CJ (2006) The transcription factor ATF-3 promotes neurite outgrowth. Mol Cell Neurosci 32(1\u20132):143\u2013154. https:\/\/doi.org\/10.1016\/j.mcn.2006.03.005","journal-title":"Mol Cell Neurosci"},{"issue":"2","key":"3887_CR18","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1006\/exnr.1998.6954","volume":"154","author":"JD Houle","year":"1998","unstructured":"Houle JD, Schramm P, Herdegen T (1998) Trophic factor modulation of c-Jun expression in supraspinal neurons after chronic spinal cord injury. Exp Neurol 154(2):602\u2013611. https:\/\/doi.org\/10.1006\/exnr.1998.6954","journal-title":"Exp Neurol"},{"issue":"5","key":"3887_CR19","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0166-2236(96)01000-4","volume":"20","author":"T Herdegen","year":"1997","unstructured":"Herdegen T, Skene P, B\u00e4hr M (1997) The c-Jun transcription factor\u2014bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 20(5):227\u2013231. https:\/\/doi.org\/10.1016\/s0166-2236(96)01000-4","journal-title":"Trends Neurosci"},{"issue":"7","key":"3887_CR20","doi-asserted-by":"publisher","first-page":"1614","DOI":"10.3390\/cells10071614","volume":"10","author":"PLM Zilundu","year":"2021","unstructured":"Zilundu PLM, Xu X, Liaquat Z, Wang Y, Zhong K, Fu R, Zhou L (2021) Long-term suppression of c-Jun and nNOS preserves ultrastructural features of lower motor neurons and forelimb function after brachial plexus roots avulsion. Cells 10(7):1614. https:\/\/doi.org\/10.3390\/cells10071614","journal-title":"Cells"},{"issue":"4","key":"3887_CR21","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1111\/j.1471-4159.2012.07706.x","volume":"121","author":"CA Ruff","year":"2012","unstructured":"Ruff CA, Staak N, Patodia S, Kaswich M, Rocha-Ferreira E, Da Costa C, Brecht S, Makwana M et al (2012) Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate. J Neurochem 121(4):607\u2013618. https:\/\/doi.org\/10.1111\/j.1471-4159.2012.07706.x","journal-title":"J Neurochem"},{"issue":"3","key":"3887_CR22","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1007\/s12031-018-1098-y","volume":"65","author":"YQ Li","year":"2018","unstructured":"Li YQ, Song FH, Zhong K, Yu GY, Zilundu PLM, Zhou YY, Fu R, Tang Y et al (2018) Pre-injection of small interfering RNA (siRNA) promotes c-Jun gene silencing and decreases the survival rate of axotomy-injured spinal motoneurons in adult mice. J Mol Neurosci 65(3):400\u2013410. https:\/\/doi.org\/10.1007\/s12031-018-1098-y","journal-title":"J Mol Neurosci"},{"issue":"29","key":"3887_CR23","doi-asserted-by":"publisher","first-page":"20450","DOI":"10.1074\/jbc.274.29.20450","volume":"274","author":"A Schweizer","year":"1999","unstructured":"Schweizer A, Valdenaire O, K\u00f6ster A, Lang Y, Schmitt G, Lenz B, Bluethmann H, Rohrer J (1999) Neonatal lethality in mice deficient in XCE, a novel member of the endothelin-converting enzyme and neutral endopeptidase family. J Biol Chem 274(29):20450\u201320456. https:\/\/doi.org\/10.1074\/jbc.274.29.20450","journal-title":"J Biol Chem"},{"issue":"6","key":"3887_CR24","doi-asserted-by":"publisher","first-page":"e2847","DOI":"10.1038\/cddis.2017.212","volume":"8","author":"A Kaneko","year":"2017","unstructured":"Kaneko A, Kiryu-Seo S, Matsumoto S, Kiyama H (2017) Damage-induced neuronal endopeptidase (DINE) enhances axonal regeneration potential of retinal ganglion cells after optic nerve injury. Cell Death Dis 8(6):e2847. https:\/\/doi.org\/10.1038\/cddis.2017.212","journal-title":"Cell Death Dis"},{"issue":"10","key":"3887_CR25","doi-asserted-by":"publisher","first-page":"3943","DOI":"10.1167\/iovs.18-23784","volume":"59","author":"K Sato","year":"2018","unstructured":"Sato K, Shiga Y, Nakagawa Y, Fujita K, Nishiguchi KM, Tawarayama H, Murayama N, Maekawa S et al (2018) Ecel1 knockdown with an AAV2-mediated CRISPR\/Cas9 system promotes optic nerve damage-induced RGC death in the mouse retina. Invest Ophthalmol Vis Sci 59(10):3943\u20133951. https:\/\/doi.org\/10.1167\/iovs.18-23784","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"3887_CR26","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.expneurol.2005.08.019","volume":"197","author":"L Zhou","year":"2006","unstructured":"Zhou L, Wu W (2006) Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat. Exp Neurol 197(1):84\u201392. https:\/\/doi.org\/10.1016\/j.expneurol.2005.08.019","journal-title":"Exp Neurol"},{"issue":"5\u20136","key":"3887_CR27","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1007\/s11068-009-9040-4","volume":"36","author":"LH Zhou","year":"2008","unstructured":"Zhou LH, Han S, Xie YY, Wang LL, Yao ZB (2008) Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats. Brain Cell Biol 36(5\u20136):213\u2013227. https:\/\/doi.org\/10.1007\/s11068-009-9040-4","journal-title":"Brain Cell Biol"},{"issue":"8","key":"3887_CR28","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.4103\/1673-5374.294565","volume":"16","author":"SQ Lv","year":"2021","unstructured":"Lv SQ, Wu W (2021) ISP and PAP4 peptides promote motor functional recovery after peripheral nerve injury. Neural Regen Res 16(8):1598\u20131605. https:\/\/doi.org\/10.4103\/1673-5374.294565","journal-title":"Neural Regen Res"},{"issue":"2","key":"3887_CR29","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1006\/exnr.1993.1050","volume":"120","author":"W Wu","year":"1993","unstructured":"Wu W (1993) Expression of nitric-oxide synthase (NOS) in injured CNS neurons as shown by NADPH diaphorase histochemistry. Exp Neurol 120(2):153\u2013159. https:\/\/doi.org\/10.1006\/exnr.1993.1050","journal-title":"Exp Neurol"},{"key":"3887_CR30","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1016\/j.neuroscience.2013.03.006","volume":"241","author":"X Cheng","year":"2013","unstructured":"Cheng X, Fu R, Gao M, Liu S, Li YQ, Song FH, Bruce IC, Zhou LH et al (2013) Intrathecal application of short interfering RNA knocks down c-jun expression and augments spinal motoneuron death after root avulsion in adult rats. Neuroscience 241:268\u2013279. https:\/\/doi.org\/10.1016\/j.neuroscience.2013.03.006","journal-title":"Neuroscience"},{"issue":"8","key":"3887_CR31","doi-asserted-by":"publisher","first-page":"1827","DOI":"10.4103\/1673-5374.332153","volume":"17","author":"W Lu","year":"2022","unstructured":"Lu W, Li JP, Jiang ZD, Yang L, Liu XZ (2022) Effects of targeted muscle reinnervation on spinal cord motor neurons in rats following tibial nerve transection. Neural Regen Res 17(8):1827\u20131832. https:\/\/doi.org\/10.4103\/1673-5374.332153","journal-title":"Neural Regen Res"},{"issue":"1","key":"3887_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1447-073x.2006.00136.x","volume":"81","author":"S Kiryu-Seo","year":"2006","unstructured":"Kiryu-Seo S (2006) Identification and functional analysis of damage-induced neuronal endopeptidase (DINE), a nerve injury associated molecule. Anat Sci Int 81(1):1\u20136. https:\/\/doi.org\/10.1111\/j.1447-073x.2006.00136.x","journal-title":"Anat Sci Int"},{"issue":"8","key":"3887_CR33","doi-asserted-by":"publisher","first-page":"4345","DOI":"10.1073\/pnas.070509897","volume":"97","author":"S Kiryu-Seo","year":"2000","unstructured":"Kiryu-Seo S, Sasaki M, Yokohama H, Nakagomi S, Hirayama T, Aoki S, Wada K, Kiyama H (2000) Damage-induced neuronal endopeptidase (DINE) is a unique metallopeptidase expressed in response to neuronal damage and activates superoxide scavengers. Proc Natl Acad Sci USA 97(8):4345\u20134350. https:\/\/doi.org\/10.1073\/pnas.070509897","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"3887_CR34","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12031-015-0588-4","volume":"57","author":"M Tan","year":"2015","unstructured":"Tan M, Yuan MZ, Sun TY, Xie YY, Liu LL, Tang Y, Ling ZM, Li YQ et al (2015) Identification of the avulsion-injured spinal motoneurons. J Mol Neurosci: MN 57(1):142\u2013151. https:\/\/doi.org\/10.1007\/s12031-015-0588-4","journal-title":"J Mol Neurosci: MN"},{"issue":"1","key":"3887_CR35","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s11033-020-06032-y","volume":"48","author":"N Fujita","year":"2021","unstructured":"Fujita N, Sase K, Tsukahara C, Arizono I, Takagi H, Kitaoka Y (2021) Pemafibrate prevents retinal neuronal cell death in NMDA-induced excitotoxicity via inhibition of p-c-Jun expression. Mol Biol Rep 48(1):195\u2013202. https:\/\/doi.org\/10.1007\/s11033-020-06032-y","journal-title":"Mol Biol Rep"},{"issue":"2","key":"3887_CR36","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s11684-018-0642-z","volume":"13","author":"B Yu","year":"2019","unstructured":"Yu B, Gu X (2019) Combination of biomaterial transplantation and genetic enhancement of intrinsic growth capacities to promote CNS axon regeneration after spinal cord injury. Front Med 13(2):131\u2013137. https:\/\/doi.org\/10.1007\/s11684-018-0642-z","journal-title":"Front Med"},{"issue":"6149","key":"3887_CR37","doi-asserted-by":"publisher","first-page":"658","DOI":"10.1038\/330658a0","volume":"330","author":"D Lindholm","year":"1987","unstructured":"Lindholm D, Heumann R, Meyer M, Thoenen H (1987) Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve. Nature 330(6149):658\u2013659. https:\/\/doi.org\/10.1038\/330658a0","journal-title":"Nature"},{"issue":"1","key":"3887_CR38","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/330658a0","volume":"29","author":"S Kiryu","year":"1995","unstructured":"Kiryu S, Morita N, Ohno K, Maeno H, Kiyama H (1995) Regulation of mRNA expression involved in Ras and PKA signal pathways during rat hypoglossal nerve regeneration. Brain Res Mol Brain Res 29(1):147\u2013156. https:\/\/doi.org\/10.1038\/330658a0","journal-title":"Brain Res Mol Brain Res"},{"issue":"2","key":"3887_CR39","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1523\/jneurosci.21-02-00363.2001","volume":"21","author":"AM Shadiack","year":"2001","unstructured":"Shadiack AM, Sun Y, Zigmond RE (2001) Nerve growth factor antiserum induces axotomy-like changes in neuropeptide expression in intact sympathetic and sensory neurons. J Neurosc 21(2):363\u2013371. https:\/\/doi.org\/10.1523\/jneurosci.21-02-00363.2001","journal-title":"J Neurosc"},{"issue":"2","key":"3887_CR40","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/neu.10308","volume":"59","author":"KL Boeshore","year":"2004","unstructured":"Boeshore KL, Schreiber RC, Vaccariello SA, Sachs HH, Salazar R, Lee J, Ratan RR, Leahy P et al (2004) Novel changes in gene expression following axotomy of a sympathetic ganglion: a microarray analysis. J Neurobiol 59(2):216\u2013235. https:\/\/doi.org\/10.1002\/neu.10308","journal-title":"J Neurobiol"},{"issue":"4","key":"3887_CR41","doi-asserted-by":"publisher","first-page":"102570","DOI":"10.1016\/j.ipm.2021.102570","volume":"58","author":"P Zhu","year":"2021","unstructured":"Zhu P, Hu J, Zhang Y, Li X (2021) Enhancing traceability of infectious diseases: a blockchain-based approach. Inf Process Manag 58(4):102570","journal-title":"Inf Process Manag"},{"issue":"5","key":"3887_CR42","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1007\/s11064-008-9848-9","volume":"34","author":"N Nguyen","year":"2009","unstructured":"Nguyen N, Lee SB, Lee YS, Lee KH, Ahn JY (2009) Neuroprotection by NGF and BDNF against neurotoxin-exerted apoptotic death in neural stem cells are mediated through Trk receptors, activating PI3-kinase and MAPK pathways. Neurochem Res 34(5):942\u2013951. https:\/\/doi.org\/10.1007\/s11064-008-9848-9","journal-title":"Neurochem Res"},{"issue":"3","key":"3887_CR43","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1016\/j.neuint.2012.05.021","volume":"61","author":"T Dal-Cim","year":"2012","unstructured":"Dal-Cim T, Molz S, Egea J, Parada E, Romero A, Budni J, Mart\u00edn de Saavedra MD, del Barrio L et al (2012) Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K\/Akt\/GSK-3\u03b2 pathway. Neurochem Int 61(3):397\u2013404. https:\/\/doi.org\/10.1016\/j.neuint.2012.05.021","journal-title":"Neurochem Int"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03887-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-023-03887-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-023-03887-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T10:12:25Z","timestamp":1721038345000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-023-03887-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,3]]},"references-count":43,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3887"],"URL":"https:\/\/doi.org\/10.1007\/s12035-023-03887-7","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,3]]},"assertion":[{"value":"18 July 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments were approved by the Animal Care and Use Committee of Sun Yat-sen University and the Guangdong Province Animal Care Ethics Committee.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}