{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T13:57:18Z","timestamp":1793627838181,"version":"4.5.1"},"reference-count":340,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1007\/s12035-024-03915-0","type":"journal-article","created":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T11:02:51Z","timestamp":1704970971000},"page":"5541-5571","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Significance of Melatonin in the Regulation of Circadian Rhythms and Disease Management"],"prefix":"10.1007","volume":"61","author":[{"given":"K. B.","family":"Megha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Arathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saini","family":"Shikha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Alka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prabhu","family":"Ramya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-2938","authenticated-orcid":false,"given":"P. V.","family":"Mohanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,1,11]]},"reference":[{"issue":"4","key":"3915_CR1","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1179\/135100003225002709","volume":"8","author":"AR Ressmeyer","year":"2003","unstructured":"Ressmeyer AR, Mayo JC, Zelosko V, S\u00e1inz RM, Tan DX, Poeggeler B et al (2003) Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction. Redox Rep 8(4):205\u2013213","journal-title":"Redox Rep"},{"issue":"2","key":"3915_CR2","first-page":"101","volume":"49","author":"M Iriti","year":"2010","unstructured":"Iriti M, Varoni EM, Vitalini S (2010) Melatonin in traditional Mediterranean diets. J Pineal Res 49(2):101\u2013105","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR3","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.mce.2012.01.004","volume":"351","author":"RM Slominski","year":"2012","unstructured":"Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT (2012) Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol Cell Endocrinol 351(2):152\u2013166","journal-title":"Mol Cell Endocrinol"},{"issue":"22","key":"3915_CR4","doi-asserted-by":"publisher","first-page":"6084","DOI":"10.1021\/ja01531a060","volume":"81","author":"AB Lerner","year":"1959","unstructured":"Lerner AB, Case JD, Heinzelman RV (1959) Structure of melatonin 1. J Am Chem Soc 81(22):6084\u20136085","journal-title":"J Am Chem Soc"},{"issue":"13","key":"3915_CR5","doi-asserted-by":"publisher","first-page":"2813","DOI":"10.1111\/j.1742-4658.2006.05322.x","volume":"273","author":"SR Pandi-Perumal","year":"2006","unstructured":"Pandi-Perumal SR, Srinivasan V, Maestroni GJM, Cardinali DP, Poeggeler B, Hardeland R (2006) Melatonin: nature\u2019s most versatile biological signal? FEBS J 273(13):2813\u20132838","journal-title":"FEBS J"},{"issue":"49","key":"3915_CR6","doi-asserted-by":"publisher","first-page":"51172","DOI":"10.1074\/jbc.M309248200","volume":"279","author":"E Garbarino-Pico","year":"2004","unstructured":"Garbarino-Pico E, Carpentieri AR, Contin MA, Sarmiento MIK, Brocco MA, Panzetta P et al (2004) Retinal ganglion cells are autonomous circadian oscillators synthesizing N-acetyl serotonin during the day. J Biol Chem 279(49):51172\u201351181","journal-title":"J Biol Chem"},{"issue":"9567","key":"3915_CR7","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/S0140-6736(07)60529-7","volume":"369","author":"J Waterhouse","year":"2007","unstructured":"Waterhouse J, Reilly T, Atkinson G, Edwards B (2007) Jet lag: trends and coping strategies. The Lancet 369(9567):1117\u20131129","journal-title":"The Lancet"},{"issue":"3","key":"3915_CR8","doi-asserted-by":"publisher","first-page":"182","DOI":"10.2174\/157015910792246245","volume":"8","author":"G Escames","year":"2010","unstructured":"Escames G, L\u00f3pez A, Antonio Garcia J, Garc\u00eda L, Acu\u00f1a-Castroviejo D, Joaquin Garcia J et al (2010) The role of mitochondria in brain ageing and the effects of melatonin. Curr Neuropharmacol 8(3):182\u2013193","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"3915_CR9","doi-asserted-by":"publisher","first-page":"367","DOI":"10.2174\/157016109788340749","volume":"7","author":"A Dominguez-Rodriguez","year":"2009","unstructured":"Dominguez-Rodriguez A, Abreu-Gonzalez P, Reiter RJ (2009) Clinical aspects of melatonin in the acute coronary syndrome. Curr Vasc Pharmacol 7(3):367\u2013373","journal-title":"Curr Vasc Pharmacol"},{"issue":"8","key":"3915_CR10","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1007\/BF01923947","volume":"49","author":"RJ Reiter","year":"1993","unstructured":"Reiter RJ (1993) The melatonin rhythm: both a clock and a calendar. Experientia 49(8):654\u2013664","journal-title":"Experientia"},{"key":"3915_CR11","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.arr.2016.11.007","volume":"35","author":"G Favero","year":"2017","unstructured":"Favero G, Franceschetti L, Buffoli B, Moghadasian MH, Reiter RJ, Rodella LF et al (2017) Melatonin: protection against age-related cardiac pathology. Ageing Res Rev 35:336\u2013349","journal-title":"Ageing Res Rev"},{"issue":"3","key":"3915_CR12","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/15622970600571822","volume":"7","author":"V Srinivasan","year":"2006","unstructured":"Srinivasan V, Smits M, Spence W, Lowe AD, Kayumov L, Pandi Perumal SR et al (2006) Melatonin in mood disorders. World J Biol Psychiatry 7(3):138\u2013151","journal-title":"World J Biol Psychiatry"},{"issue":"4","key":"3915_CR13","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1111\/jpi.12267","volume":"59","author":"LC Manchester","year":"2015","unstructured":"Manchester LC, Coto-Montes A, Boga JA, Andersen LPH, Zhou Z, Galano A et al (2015) Melatonin: an ancient molecule that makes oxygen metabolically tolerable. J Pineal Res 59(4):403\u2013419","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR14","first-page":"27","volume":"10","author":"P Lissoni","year":"1996","unstructured":"Lissoni P, Pittalis S, Rovelli F, Zecchini S, Casati M, Tremolada M et al (1996) Immunomodulatory properties of a pineal indole hormone other than melatonin, the 5-methoxytryptophol. J Biol Regul Homeost Agents 10(1):27\u201330","journal-title":"J Biol Regul Homeost Agents"},{"issue":"6","key":"3915_CR15","first-page":"288","volume":"11","author":"G Mazzoccoli","year":"2005","unstructured":"Mazzoccoli G, Carughi S, de Cata A, La Viola M, Vendemiale G (2005) Melatonin and cortisol serum levels in lung cancer patients at different stages of disease. Med Sci Monit 11(6):288","journal-title":"Med Sci Monit"},{"key":"3915_CR16","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.jpsychores.2016.05.005","volume":"86","author":"RM Scholtens","year":"2016","unstructured":"Scholtens RM, van Munster BC, van Kempen MF, de Rooij SEJA (2016) Physiological melatonin levels in healthy older people: a systematic review. J Psychosom Res 86:20\u201327","journal-title":"J Psychosom Res"},{"issue":"2","key":"3915_CR17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1016\/j.pharmthera.2013.01.005","volume":"138","author":"L Lanfumey","year":"2013","unstructured":"Lanfumey L, Mongeau R, Hamon M (2013) Biological rhythms and melatonin in mood disorders and their treatments. Pharmacol Ther 138(2):176\u2013184","journal-title":"Pharmacol Ther"},{"key":"3915_CR18","first-page":"14","volume":"23","author":"M Karasek","year":"2002","unstructured":"Karasek M, Reiter RJ (2002) Melatonin and aging. Neuroendocrinol Lett 23:14\u201316","journal-title":"Neuroendocrinol Lett"},{"issue":"4","key":"3915_CR19","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1111\/jpi.12090","volume":"55","author":"R Hardeland","year":"2013","unstructured":"Hardeland R (2013) Melatonin and the theories of aging: a critical appraisal of melatonin\u2019s role in antiaging mechanisms. J Pineal Res 55(4):325\u2013356","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR20","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cell.2014.09.004","volume":"159","author":"KJ Schippers","year":"2014","unstructured":"Schippers KJ, Nichols SA (2014) Deep, dark secrets of melatonin in animal evolution. Cell 159(1):9\u201310","journal-title":"Cell"},{"key":"3915_CR21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.4172\/2168-975X.1000151","volume":"4","author":"A Masters","year":"2015","unstructured":"Masters A, Pandi-Perumal SR, Seixas A, Girardin Jean-Louis G, McFarlane SI (2015) Melatonin, the hormone of darkness: From sleep promotion to ebola treatment. Brain Disord Ther 4:151. https:\/\/doi.org\/10.4172\/2168-975X.1000151","journal-title":"Brain Disord Ther"},{"issue":"9","key":"3915_CR22","first-page":"1631","volume":"19","author":"CY Chen","year":"1998","unstructured":"Chen CY, Chen FH, Lee CC, Lee KW, Hsiao HS (1998) Sonographic characteristics of the cavum velum interpositum. Am J Neuroradiol 19(9):1631\u20131635","journal-title":"Am J Neuroradiol"},{"issue":"2","key":"3915_CR23","doi-asserted-by":"publisher","first-page":"301","DOI":"10.3390\/molecules23020301","volume":"23","author":"DX Tan","year":"2018","unstructured":"Tan DX, Xu B, Zhou X, Reiter RJ (2018) Pineal calcification, melatonin production, aging, associated health consequences and rejuvenation of the pineal gland. Molecules 23(2):301","journal-title":"Molecules"},{"issue":"1","key":"3915_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1471-2350-12-17","volume":"12","author":"C Pagan","year":"2011","unstructured":"Pagan C, Botros HG, Poirier K, Dumaine A, Jamain S, Moreno S et al (2011) Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with intellectual disability. BMC Med Genet 12(1):1\u20136","journal-title":"BMC Med Genet"},{"issue":"3","key":"3915_CR25","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1016\/j.neurol.2019.07.025","volume":"176","author":"M Gunata","year":"2020","unstructured":"Gunata M, Parlakpinar H, Acet HA (2020) Melatonin: a review of its potential functions and effects on neurological diseases. Rev Neurol (Paris) 176(3):148\u2013165","journal-title":"Rev Neurol (Paris)"},{"issue":"1\u20132","key":"3915_CR26","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1016\/j.lfs.2007.10.016","volume":"82","author":"RAP Garcia","year":"2008","unstructured":"Garcia RAP, Afeche SC, Scialfa JH, do Amaral FG, dos Santos SHJ, Lima FB et al (2008) Insulin modulates norepinephrine-mediated melatonin synthesis in cultured rat pineal gland. Life Sci. 82(1\u20132):108\u201314","journal-title":"Life Sci."},{"key":"3915_CR27","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3389\/fnagi.2017.00165","volume":"9","author":"WC Liu","year":"2017","unstructured":"Liu WC, Wang X, Zhang X, Chen X, Jin X (2017) Melatonin supplementation, a strategy to prevent neurological diseases through maintaining integrity of blood brain barrier in old people. Front Aging Neurosci 9:165","journal-title":"Front Aging Neurosci"},{"key":"3915_CR28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.exer.2012.08.009","volume":"103","author":"G Tosini","year":"2012","unstructured":"Tosini G, Baba K, Hwang CK, Iuvone PM (2012) Melatonin: an underappreciated player in retinal physiology and pathophysiology. Exp Eye Res 103:82\u201389","journal-title":"Exp Eye Res"},{"key":"3915_CR29","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/B978-0-12-405210-9.00006-0","volume":"300","author":"AF Wiechmann","year":"2013","unstructured":"Wiechmann AF, Sherry DM (2013) Role of melatonin and its receptors in the vertebrate retina. Int Rev Cell Mol Biol 300:211\u2013242","journal-title":"Int Rev Cell Mol Biol"},{"issue":"9","key":"3915_CR30","doi-asserted-by":"publisher","first-page":"e106819","DOI":"10.1371\/journal.pone.0106819","volume":"9","author":"S Hiragaki","year":"2014","unstructured":"Hiragaki S, Baba K, Coulson E, Kunst S, Spessert R, Tosini G (2014) Melatonin signalling modulates clock genes expression in the mouse retina. PLoS ONE 9(9):e106819","journal-title":"PLoS ONE"},{"issue":"30","key":"3915_CR31","doi-asserted-by":"publisher","first-page":"4785","DOI":"10.2174\/1381612819666131119111201","volume":"20","author":"T Brzozowski","year":"2014","unstructured":"Brzozowski T, Jaworek J (2014) Editorial (Thematic issues: basic and clinical aspects of melatonin in the gastrointestinal tract. new advancements and future perspectives). Curr Pharm Des. 20(30):4785\u20137","journal-title":"Curr Pharm Des."},{"issue":"4","key":"3915_CR32","doi-asserted-by":"publisher","first-page":"61","DOI":"10.32794\/mr11250041","volume":"2","author":"PK Pal","year":"2019","unstructured":"Pal PK, Sarkar S, Chattopadhyay A, Tan DX, Bandyopadhyay D (2019) Enterochromaffin cells as the source of melatonin: key findings and functional relevance in mammals. Melatonin Res 2(4):61\u201382","journal-title":"Melatonin Res"},{"issue":"7","key":"3915_CR33","doi-asserted-by":"publisher","first-page":"3758","DOI":"10.3390\/ijms23073758","volume":"23","author":"R Rezzani","year":"2022","unstructured":"Rezzani R, Franco C, Franceschetti L, Gian\u00f2 M, Favero G (2022) A focus on enterochromaffin cells among the enteroendocrine cells: localization, morphology, and role. Int J Mol Sci 23(7):3758","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3915_CR34","doi-asserted-by":"publisher","first-page":"E1942","DOI":"10.1073\/pnas.1722131115","volume":"115","author":"A Ahluwalia","year":"2018","unstructured":"Ahluwalia A, Brzozowska IM, Hoa N, Jones MK, Tarnawski AS (2018) Melatonin signaling in mitochondria extends beyond neurons and neuroprotection: implications for angiogenesis and cardio\/gastroprotection. Proc Natl Acad Sci 115(9):E1942\u2013E1943","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"3915_CR35","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1080\/19490976.2016.1208892","volume":"7","author":"JK Paulose","year":"2016","unstructured":"Paulose JK, Cassone VM (2016) The melatonin-sensitive circadian clock of the enteric bacterium Enterobacter aerogenes. Gut Microbes 7(5):424\u2013427","journal-title":"Gut Microbes"},{"key":"3915_CR36","doi-asserted-by":"publisher","unstructured":"Zhu D, Ma Y, Ding S, Jiang H, Fang J (2018) Effects of melatonin on intestinal microbiota and oxidative stress in colitis mice. Biomed Res Int 2018(2607679):6. https:\/\/doi.org\/10.1155\/2018\/2607679","DOI":"10.1155\/2018\/2607679"},{"issue":"7","key":"3915_CR37","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1016\/j.lfs.2004.03.003","volume":"75","author":"J Leon","year":"2004","unstructured":"Leon J, Acu\u00f1a-Castroviejo D, Sainz RM, Mayo JC, Tan DX, Reiter RJ (2004) Melatonin and mitochondrial function. Life Sci 75(7):765\u2013790","journal-title":"Life Sci"},{"issue":"1","key":"3915_CR38","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1021\/tx700210j","volume":"21","author":"LM Sayre","year":"2008","unstructured":"Sayre LM, Perry G, Smith MA (2008) Oxidative stress and neurotoxicity. Chem Res Toxicol 21(1):172\u2013188","journal-title":"Chem Res Toxicol"},{"issue":"1","key":"3915_CR39","doi-asserted-by":"publisher","first-page":"e12514","DOI":"10.1111\/jpi.12514","volume":"65","author":"A Galano","year":"2018","unstructured":"Galano A, Reiter RJ (2018) Melatonin and its metabolites vs oxidative stress: from individual actions to collective protection. J Pineal Res 65(1):e12514","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR40","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/0891-5849(88)90043-3","volume":"4","author":"WA Pryor","year":"1988","unstructured":"Pryor WA (1988) Why is the hydroxyl radical the only radical that commonly adds to DNA? Hypothesis: it has a rare combination of high electrophilicity, high thermochemical reactivity, and a mode of production that can occur near DNA. Free Radical Biol Med 4(4):219\u2013223","journal-title":"Free Radical Biol Med"},{"issue":"3","key":"3915_CR41","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1002\/(SICI)1521-3765(20000204)6:3<475::AID-CHEM475>3.0.CO;2-E","volume":"6","author":"LP Candeias","year":"2000","unstructured":"Candeias LP, Steenken S (2000) Reaction of HO* with guanine derivatives in aqueous solution: formation of two different redox-active OH-adduct radicals and their unimolecular transformation reactions. Properties of G(-H)*. Chemistry. 6(3):475\u201384","journal-title":"Chemistry."},{"issue":"5","key":"3915_CR42","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1016\/S0891-5849(00)00373-7","volume":"30","author":"R Radi","year":"2001","unstructured":"Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A (2001) Unraveling peroxynitrite formation in biological systems. Free Radical Biol Med 30(5):463\u2013488","journal-title":"Free Radical Biol Med"},{"issue":"5","key":"3915_CR43","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3109\/10715769609088035","volume":"24","author":"T Douki","year":"1996","unstructured":"Douki T, Cadet J (1996) Peroxynitrite mediated oxidation of purine bases of nucleosides and isolated DNA. Free Radic Res 24(5):369\u2013380","journal-title":"Free Radic Res"},{"issue":"10","key":"3915_CR44","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.1016\/S0891-5849(01)00710-9","volume":"31","author":"GI Giles","year":"2001","unstructured":"Giles GI, Tasker KM, Jacob C (2001) Hypothesis: the role of reactive sulfur species in oxidative stress. Free Radical Biol Med 31(10):1279\u20131283","journal-title":"Free Radical Biol Med"},{"issue":"2","key":"3915_CR45","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.abb.2008.01.009","volume":"471","author":"P Dungel","year":"2008","unstructured":"Dungel P, Mittermayr R, Haindl S, Osipov A, Wagner C, Redl H et al (2008) Illumination with blue light reactivates respiratory activity of mitochondria inhibited by nitric oxide, but not by glycerol trinitrate. Arch Biochem Biophys 471(2):109\u2013115","journal-title":"Arch Biochem Biophys"},{"issue":"1","key":"3915_CR46","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1111\/j.1600-079X.2006.00407.x","volume":"42","author":"D Tan","year":"2007","unstructured":"Tan D, Manchester LC, Terron MP, Flores LJ, Reiter RJ (2007) One molecule, many derivatives: an ever-ending interaction of melatonin with reactive oxygen and nitrogen species? J Pineal Res 42(1):28\u201342","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR47","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1046\/j.1600-079X.2003.00092.x","volume":"36","author":"C Rodriguez","year":"2004","unstructured":"Rodriguez C, Mayo JC, Sainz RM, Antol\u00edn I, Herrera F, Mart\u00edn V et al (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36(1):1\u20139","journal-title":"J Pineal Res"},{"issue":"9","key":"3915_CR48","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1111\/j.1600-0625.2008.00767.x","volume":"17","author":"TW Fischer","year":"2008","unstructured":"Fischer TW, Slominski A, Zmijewski MA, Reiter RJ, Paus R (2008) Melatonin as a major skin protectant: from free radical scavenging to DNA damage repair. Exp Dermatol 17(9):713\u2013730","journal-title":"Exp Dermatol"},{"issue":"4","key":"3915_CR49","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1080\/10409230903044914","volume":"44","author":"RJ Reiter","year":"2009","unstructured":"Reiter RJ, Paredes SD, Manchester LC, Tan DX (2009) Reducing oxidative\/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev Biochem Mol Biol 44(4):175\u2013200","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"15","key":"3915_CR50","doi-asserted-by":"publisher","first-page":"7178","DOI":"10.1039\/c0cp02801k","volume":"13","author":"A Galano","year":"2011","unstructured":"Galano A (2011) On the direct scavenging activity of melatonin towards hydroxyl and a series of peroxyl radicals. Phys Chem Chem Phys 13(15):7178\u20137188","journal-title":"Phys Chem Chem Phys"},{"issue":"3","key":"3915_CR51","first-page":"245","volume":"54","author":"A Galano","year":"2013","unstructured":"Galano A, Tan DX, Reiter RJ (2013) On the free radical scavenging activities of melatonin\u2019s metabolites. AFMK and AMK J Pineal Res 54(3):245\u2013257","journal-title":"AFMK and AMK J Pineal Res"},{"issue":"1\u20132","key":"3915_CR52","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000014571","volume":"8","author":"DX Tan","year":"1999","unstructured":"Tan DX, Manchester L, Reiter R, Plummer B (1999) Cyclic 3-hydroxymelatonin: a melatonin metabolite generated as a result of hydroxyl radical scavenging. Neurosignals 8(1\u20132):70\u201374","journal-title":"Neurosignals"},{"issue":"2","key":"3915_CR53","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1385\/ENDO:27:2:119","volume":"27","author":"R Hardeland","year":"2005","unstructured":"Hardeland R (2005) Antioxidative protection by melatonin. Endocrine 27(2):119\u2013130","journal-title":"Endocrine"},{"issue":"5","key":"3915_CR54","doi-asserted-by":"publisher","first-page":"1787","DOI":"10.1096\/fj.201601326R","volume":"31","author":"M Antonelli","year":"2017","unstructured":"Antonelli M, Kushner I (2017) It\u2019s time to redefine inflammation. FASEB J 31(5):1787\u20131791","journal-title":"FASEB J"},{"issue":"9","key":"3915_CR55","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.362","volume":"5","author":"N Garg","year":"2015","unstructured":"Garg N, Smith TW (2015) An update on immunopathogenesis, diagnosis, and treatment of multiple sclerosis. Brain Behav 5(9):e00362","journal-title":"Brain Behav"},{"issue":"1","key":"3915_CR56","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-079X.2012.01014.x","volume":"54","author":"JL Mauriz","year":"2013","unstructured":"Mauriz JL, Collado PS, Veneroso C, Reiter RJ, Gonz\u00e1lez-Gallego J (2013) A review of the molecular aspects of melatonin\u2019s anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 54(1):1\u201314","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR57","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1111\/jpi.12012","volume":"54","author":"A Agil","year":"2013","unstructured":"Agil A, Reiter RJ, Jim\u00e9nez-Aranda A, Ib\u00e1n-Arias R, Navarro-Alarc\u00f3n M, Marchal JA et al (2013) Melatonin ameliorates low-grade inflammation and oxidative stress in young Zucker diabetic fatty rats. J Pineal Res 54(4):381\u2013388","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR58","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0092-8674(00)81318-5","volume":"87","author":"PA Baeuerle","year":"1996","unstructured":"Baeuerle PA, Baltimore D (1996) NF-\u03baB: ten years after. Cell 87(1):13\u201320","journal-title":"Cell"},{"issue":"3","key":"3915_CR59","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1056\/NEJM199701163360306","volume":"336","author":"A Brzezinski","year":"1997","unstructured":"Brzezinski A (1997) Melatonin in humans. N Engl J Med 336(3):186\u2013195","journal-title":"N Engl J Med"},{"issue":"9","key":"3915_CR60","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1096\/fasebj.14.9.1061","volume":"14","author":"S Cuzzocrea","year":"2000","unstructured":"Cuzzocrea S, Misko TP, Costantino G, Mazzon E, Micali A, Caputi AP et al (2000) Beneficial effects of peroxynitrite decomposition catalyst in a rat model of splanchnic artery occlusion and reperfusion. FASEB J 14(9):1061\u20131072","journal-title":"FASEB J"},{"issue":"2","key":"3915_CR61","doi-asserted-by":"publisher","first-page":"153","DOI":"10.2174\/1568026023394425","volume":"2","author":"S Cuzzocrea","year":"2002","unstructured":"Cuzzocrea S, Reiter RJ (2002) Pharmacological actions of melatonin in acute and chronic inflammation. Curr Top Med Chem 2(2):153\u2013165","journal-title":"Curr Top Med Chem"},{"issue":"3","key":"3915_CR62","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.pneurobio.2010.12.004","volume":"93","author":"R Hardeland","year":"2011","unstructured":"Hardeland R, Cardinali DP, Srinivasan V, Spence DW, Brown GM, Pandi-Perumal SR (2011) Melatonin\u2014a pleiotropic, orchestrating regulator molecule. Prog Neurobiol 93(3):350\u2013384","journal-title":"Prog Neurobiol"},{"issue":"1","key":"3915_CR63","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1111\/j.1749-6632.2000.tb05402.x","volume":"917","author":"RJ Reiter","year":"2000","unstructured":"Reiter RJ, Calvo JR, Karbownik M, Qi W, Tan DX (2000) Melatonin and its relation to the immune system and inflammation. Ann NY Acad Sci 917(1):376\u2013386","journal-title":"Ann NY Acad Sci"},{"issue":"6","key":"3915_CR64","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/S0008-6363(96)00030-2","volume":"31","author":"S Bertuglia","year":"1996","unstructured":"Bertuglia S, Marchiafava PL, Colantuoni A (1996) Melatonin prevents ischemia reperfusion injury in hamster cheek pouch microcirculation. Cardiovasc Res 31(6):947\u2013952","journal-title":"Cardiovasc Res"},{"issue":"1","key":"3915_CR65","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/j.1651-2227.1990.tb11322.x","volume":"79","author":"JK Lloyd","year":"1990","unstructured":"Lloyd JK (1990) The importance of vitamin E in human nutrition. Acta P\u00e6diatrica. 79(1):6\u201311","journal-title":"Acta P\u00e6diatrica."},{"issue":"1","key":"3915_CR66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-079X.2011.00916.x","volume":"51","author":"A Galano","year":"2011","unstructured":"Galano A, Tan DX, Reiter RJ (2011) Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 51(1):1\u201316","journal-title":"J Pineal Res"},{"key":"3915_CR67","first-page":"119","volume-title":"Inflammasomes in liver fibrosis. In: Seminars in liver disease","author":"F Alegre","year":"2017","unstructured":"Alegre F, Pelegrin P, Feldstein AE (2017) Inflammasomes in liver fibrosis. In: Seminars in liver disease. Thieme Medical Publishers, Seventh Avenue, New York, NY, USA, pp 119\u2013127"},{"issue":"1","key":"3915_CR68","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1146\/annurev-cellbio-101011-155745","volume":"28","author":"M Lamkanfi","year":"2012","unstructured":"Lamkanfi M, Dixit VM (2012) Inflammasomes and their roles in health and disease. Annu Rev Cell DevBiol 28(1):137\u2013161","journal-title":"Annu Rev Cell DevBiol"},{"issue":"1\u20132","key":"3915_CR69","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.bbrc.2015.10.105","volume":"468","author":"P Liu","year":"2015","unstructured":"Liu P, Xie Q, Wei T, Chen Y, Chen H, Shen W (2015) Activation of the NLRP3 inflammasome induces vascular dysfunction in obese OLETF rats. Biochem Biophys Res Commun 468(1\u20132):319\u2013325","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"3915_CR70","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174474","volume":"12","author":"B Fern\u00e1ndez-Gil","year":"2017","unstructured":"Fern\u00e1ndez-Gil B, Moneim AEA, Ortiz F, Shen YQ, Soto-Mercado V, Mendivil-Perez M et al (2017) Melatonin protects rats from radiotherapy-induced small intestine toxicity. PLoS ONE 12(4):e0174474","journal-title":"PLoS ONE"},{"issue":"1","key":"3915_CR71","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12410","volume":"63","author":"I Rahim","year":"2017","unstructured":"Rahim I, Djerdjouri B, Sayed RK, Fern\u00e1ndez-Ortiz M, Fern\u00e1ndez-Gil B, Hidalgo-Guti\u00e9rrez A et al (2017) Melatonin administration to wild-type mice and nontreated NLRP 3 mutant mice share similar inhibition of the inflammatory response during sepsis. J Pineal Res 63(1):e12410","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR72","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1038\/jcbfm.2013.242","volume":"34","author":"F Yang","year":"2014","unstructured":"Yang F, Wang Z, Wei X, Han H, Meng X, Zhang Y et al (2014) NLRP3 deficiency ameliorates neurovascular damage in experimental ischemic stroke. J Cereb Blood Flow Metab 34(4):660\u2013667","journal-title":"J Cereb Blood Flow Metab"},{"issue":"2","key":"3915_CR73","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.molimm.2014.12.018","volume":"65","author":"Z Yang","year":"2015","unstructured":"Yang Z, Zhong L, Xian R, Yuan B (2015) MicroRNA-223 regulates inflammation and brain injury via feedback to NLRP3 inflammasome after intracerebral hemorrhage. Mol Immunol 65(2):267\u2013276","journal-title":"Mol Immunol"},{"issue":"3","key":"3915_CR74","doi-asserted-by":"publisher","first-page":"434","DOI":"10.2174\/1570159X14666161228122115","volume":"15","author":"S Tordjman","year":"2017","unstructured":"Tordjman S, Chokron S, Delorme R, Charrier A, Bellissant E, Jaafari N et al (2017) Melatonin: pharmacology, functions and therapeutic benefits. Curr Neuropharmacol 15(3):434\u2013443","journal-title":"Curr Neuropharmacol"},{"issue":"2","key":"3915_CR75","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.3390\/ijms14022410","volume":"14","author":"G di Bella","year":"2013","unstructured":"di Bella G, Mascia F, Gualano L, di Bella L (2013) Melatonin anticancer effects. Int J Mol Sci 14(2):2410\u20132430","journal-title":"Int J Mol Sci"},{"key":"3915_CR76","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1146\/annurev-pharmtox-010814-124742","volume":"56","author":"J Liu","year":"2016","unstructured":"Liu J, Clough SJ, Hutchinson AJ, Adamah-Biassi EB, Popovska-Gorevski M, Dubocovich ML (2016) MT1 and MT2 melatonin receptors: a therapeutic perspective. Annu Rev Pharmacol Toxicol 56:361","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"2","key":"3915_CR77","doi-asserted-by":"publisher","first-page":"150","DOI":"10.2174\/1874467213666200421160835","volume":"14","author":"P Wongprayoon","year":"2021","unstructured":"Wongprayoon P, Govitrapong P (2021) Melatonin receptor as a drug target for neuroprotection. Curr Mol Pharmacol 14(2):150\u2013164","journal-title":"Curr Mol Pharmacol"},{"issue":"12","key":"3915_CR78","doi-asserted-by":"publisher","first-page":"2630","DOI":"10.1002\/jnr.22430","volume":"88","author":"CH Lee","year":"2010","unstructured":"Lee CH, Yoo K, Choi JH, Park OK, Hwang IK, Kwon Y et al (2010) Melatonin\u2019s protective action against ischemic neuronal damage is associated with up-regulation of the MT2 melatonin receptor. J Neurosci Res 88(12):2630\u20132640","journal-title":"J Neurosci Res"},{"key":"3915_CR79","first-page":"377","volume-title":"rontiers in Physiology","author":"RJ Reiter","year":"2014","unstructured":"Reiter RJ, Tan DX, Galano A (2014) Melatonin reduces lipid peroxidation and membrane viscosity. rontiers in Physiology, vol 5. Frontiers Media SA, p 377"},{"issue":"1","key":"3915_CR80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13063-021-05034-w","volume":"22","author":"F Garofoli","year":"2021","unstructured":"Garofoli F, Longo S, Pisoni C, Accorsi P, Angelini M, Aversa S et al (2021) Oral melatonin as a new tool for neuroprotection in preterm newborns: study protocol for a randomized controlled trial. Trials 22(1):1\u201312","journal-title":"Trials"},{"key":"3915_CR81","doi-asserted-by":"publisher","first-page":"680899","DOI":"10.3389\/fnsyn.2021.680","volume":"13","author":"NA Elsayed","year":"2021","unstructured":"Elsayed NA, Boyer TM, Burd I (2021) Fetal neuroprotective strategies: Therapeutic agents and their underlying synaptic pathways. Front Synaptic Neurosci 13:680899. https:\/\/doi.org\/10.3389\/fnsyn.2021.680899","journal-title":"Front Synaptic Neurosci"},{"issue":"9","key":"3915_CR82","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.freeradbiomed.2012.01.030","volume":"52","author":"CM Chern","year":"2012","unstructured":"Chern CM, Liao JF, Wang YH, Shen YC (2012) Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Free Radical Biol Med 52(9):1634\u20131647","journal-title":"Free Radical Biol Med"},{"issue":"3","key":"3915_CR83","doi-asserted-by":"publisher","first-page":"373","DOI":"10.4103\/1673-5374.228711","volume":"13","author":"RHC Lee","year":"2018","unstructured":"Lee RHC, Lee MHH, Wu CYC, e Silva AC, Possoit HE, Hsieh TH et al (2018) Cerebral ischemia and neuroregeneration. Neural Regen Res. 13(3):373","journal-title":"Neural Regen Res."},{"issue":"8","key":"3915_CR84","doi-asserted-by":"publisher","first-page":"672","DOI":"10.3390\/antiox9080672","volume":"9","author":"N Sadanandan","year":"2020","unstructured":"Sadanandan N, Cozene B, Cho J, Park YJ, Saft M, Gonzales-Portillo B et al (2020) Melatonin\u2014a potent therapeutic for stroke and stroke-related dementia. Antioxidants 9(8):672","journal-title":"Antioxidants"},{"key":"3915_CR85","doi-asserted-by":"publisher","first-page":"848","DOI":"10.3389\/fnins.2020.00848","volume":"14","author":"K Wang","year":"2020","unstructured":"Wang K, Ru J, Zhang H, Chen J, Lin X, Lin Z et al (2020) Melatonin enhances the therapeutic effect of plasma exosomes against cerebral ischemia-induced pyroptosis through the TLR4\/NF-\u03baB pathway. Front Neurosci 14:848","journal-title":"Front Neurosci"},{"issue":"12","key":"3915_CR86","doi-asserted-by":"publisher","first-page":"8255","DOI":"10.1007\/s12035-019-01660-3","volume":"56","author":"M Hossain","year":"2019","unstructured":"Hossain M, Uddin M, Uddin GM, Sumsuzzman DM, Islam M, Barreto GE et al (2019) Melatonin in Alzheimer\u2019s disease: a latent endogenous regulator of neurogenesis to mitigate Alzheimer\u2019s neuropathology. Mol Neurobiol 56(12):8255\u20138276","journal-title":"Mol Neurobiol"},{"key":"3915_CR87","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2020.101804","volume":"108","author":"M Ramezani","year":"2020","unstructured":"Ramezani M, Komaki A, Hashemi-Firouzi N, Mortezaee K, Faraji N, Golipoor Z (2020) Therapeutic effects of melatonin-treated bone marrow mesenchymal stem cells (BMSC) in a rat model of Alzheimer\u2019s disease. J Chem Neuroanat 108:101804","journal-title":"J Chem Neuroanat"},{"issue":"4","key":"3915_CR88","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1016\/j.parkreldis.2008.07.008","volume":"15","author":"J Ma","year":"2009","unstructured":"Ma J, Shaw VE, Mitrofanis J (2009) Does melatonin help save dopaminergic cells in MPTP-treated mice? Parkinsonism Relat Disord 15(4):307\u2013314","journal-title":"Parkinsonism Relat Disord"},{"issue":"3","key":"3915_CR89","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1111\/jpi.12212","volume":"58","author":"A Naskar","year":"2015","unstructured":"Naskar A, Prabhakar V, Singh R, Dutta D, Mohanakumar KP (2015) Melatonin enhances L-DOPA therapeutic effects, helps to reduce its dose, and protects dopaminergic neurons in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinsonism in mice. J Pineal Res 58(3):262\u2013274","journal-title":"J Pineal Res"},{"issue":"3","key":"3915_CR90","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/jp.2014.186","volume":"35","author":"H Aly","year":"2015","unstructured":"Aly H, Elmahdy H, El-Dib M, Rowisha M, Awny M, El-Gohary T et al (2015) Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study. J Perinatol 35(3):186\u2013191","journal-title":"J Perinatol"},{"issue":"8","key":"3915_CR91","doi-asserted-by":"publisher","first-page":"463","DOI":"10.5498\/wjp.v11.i8.463","volume":"11","author":"C Duan","year":"2021","unstructured":"Duan C, Jenkins ZM, Castle D (2021) Therapeutic use of melatonin in schizophrenia: a systematic review. World J Psychiatry 11(8):463","journal-title":"World J Psychiatry"},{"key":"3915_CR92","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fendo.2019.00037","volume":"10","author":"T Shomrat","year":"2019","unstructured":"Shomrat T, Nesher N (2019) Updated view on the relation of the pineal gland to autism spectrum disorders. Front Endocrinol (Lausanne) 10:37","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"3915_CR93","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3727\/000000003108746786","volume":"12","author":"CV Borlongan","year":"2003","unstructured":"Borlongan CV, Sumaya I, Moss D, Kumazaki M, Sakurai T, Hida H, Nishino H (2003) Melatonin-secreting pineal gland: a novel tissue source for neural transplantation therapy in stroke. Cell Transplant 12(3):225\u2013234","journal-title":"Cell Transplant"},{"issue":"2","key":"3915_CR94","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1111\/j.1600-079X.2006.00351.x","volume":"41","author":"HY Chen","year":"2006","unstructured":"Chen HY, Chen TY, Lee MY, Chen ST, Hsu YS, Kuo YL, Chang GL, Wu TS, Lee EJ (2006) Melatonin decreases neurovascular oxidative\/nitrosative damage and protects against early increases in the blood\u2013brain barrier permeability after transient focal cerebral ischemia in mice. J Pineal Res 41(2):175\u2013182","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR95","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1038\/nrn2967","volume":"12","author":"LM Ittner","year":"2011","unstructured":"Ittner LM, G\u00f6tz J (2011) Amyloid-\u03b2 and tau\u2014a toxic pas de deux in Alzheimer\u2019s disease. Nat Rev Neurosci 12(2):67\u201372","journal-title":"Nat Rev Neurosci"},{"issue":"1","key":"3915_CR96","doi-asserted-by":"publisher","first-page":"117","DOI":"10.3233\/JAD-2008-15110","volume":"15","author":"I Baldeiras","year":"2008","unstructured":"Baldeiras I, Santana I, Proen\u00e7a MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D, Oliveira CR (2008) Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer\u2019s disease. J Alzheimers Dis 15(1):117\u2013128","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"3915_CR97","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1600-079X.2009.00692.x","volume":"47","author":"JM Olcese","year":"2009","unstructured":"Olcese JM, Cao C, Mori T, Mamcarz MB, Maxwell A, Runfeldt MJ, Wang L, Zhang C, Lin X, Zhang G, Arendash GW (2009) Protection against cognitive deficits and markers of neurodegeneration by long-term oral administration of melatonin in a transgenic model of Alzheimer disease. J Pineal Res 47(1):82\u201396","journal-title":"J Pineal Res"},{"issue":"5","key":"3915_CR98","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1016\/S0002-9440(10)65396-5","volume":"154","author":"J Zhang","year":"1999","unstructured":"Zhang J, Perry G, Smith MA, Robertson D, Olson SJ, Graham DG, Montine TJ (1999) Parkinson\u2019s disease is associated with oxidative damage to cytoplasmic DNA and RNA in substantia nigra neurons. Am J Pathol 154(5):1423\u20131429","journal-title":"Am J Pathol"},{"issue":"2","key":"3915_CR99","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/j.1600-079X.2010.00819.x","volume":"50","author":"NK Singhal","year":"2011","unstructured":"Singhal NK, Srivastava G, Patel DK, Jain SK, Singh MP (2011) Melatonin or silymarin reduces maneb-and paraquat-induced Parkinson\u2019s disease phenotype in the mouse. J Pineal Res 50(2):97\u2013109","journal-title":"J Pineal Res"},{"issue":"3","key":"3915_CR100","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12596","volume":"67","author":"Y Xi","year":"2019","unstructured":"Xi Y, Liu M, Xu S, Hong H, Chen M, Tian L, Xie J, Deng P, Zhou C, Zhang L, He M (2019) Inhibition of SERPINA3N-dependent neuroinflammation is essential for melatonin to ameliorate trimethyl tin chloride\u2013induced neurotoxicity. J Pineal Res 67(3):e12596","journal-title":"J Pineal Res"},{"key":"3915_CR101","doi-asserted-by":"publisher","first-page":"2019","DOI":"10.2147\/OTT.S298512","volume":"18","author":"S Gurunathan","year":"2021","unstructured":"Gurunathan S, Qasim M, Kang MH, Kim JH (2021) Role and therapeutic potential of melatonin in various type of cancers. Onco Targets Ther 18:2019\u20132052","journal-title":"Onco Targets Ther"},{"key":"3915_CR102","doi-asserted-by":"publisher","first-page":"10187","DOI":"10.2147\/OTT.S226140","volume":"12","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Tu J, Wang X, Yu Y, Li J, Jin Y, Wu J (2019) The therapeutic effect of melatonin on GC by inducing cell apoptosis and autophagy induced by endoplasmic reticulum stress. Onco Targets Ther 12:10187","journal-title":"Onco Targets Ther"},{"issue":"1","key":"3915_CR103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12935-019-0853-7","volume":"19","author":"MH Pourhanifeh","year":"2019","unstructured":"Pourhanifeh MH, Sharifi M, Reiter RJ, Davoodabadi A, Asemi Z (2019) Melatonin and non-small cell lung cancer: new insights into signaling pathways. Cancer Cell Int 19(1):1\u20137","journal-title":"Cancer Cell Int"},{"issue":"11","key":"3915_CR104","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.tem.2020.08.001","volume":"31","author":"X Kong","year":"2020","unstructured":"Kong X, Gao R, Wang Z, Wang X, Fang Y, Gao J, Reiter RJ, Wang J (2020) Melatonin: a potential therapeutic option for breast cancer. Trends Endocrinol Metab 31(11):859\u2013871","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"3915_CR105","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3390\/molecules23020336","volume":"23","author":"A Gonz\u00e1lez-Gonz\u00e1lez","year":"2018","unstructured":"Gonz\u00e1lez-Gonz\u00e1lez A, Mediavilla MD, S\u00e1nchez-Barcel\u00f3 EJ (2018) Melatonin: a molecule for reducing breast cancer risk. Molecules 23(2):336","journal-title":"Molecules"},{"issue":"3","key":"3915_CR106","doi-asserted-by":"publisher","first-page":"599","DOI":"10.3390\/cells9030599","volume":"9","author":"E Moretti","year":"2020","unstructured":"Moretti E, Favero G, Rodella LF, Rezzani R (2020) Melatonin\u2019s antineoplastic potential against glioblastoma. Cells 9(3):599","journal-title":"Cells"},{"issue":"1","key":"3915_CR107","doi-asserted-by":"publisher","first-page":"e08837","DOI":"10.1016\/j.heliyon.2022.e08837","volume":"8","author":"OA Ammar","year":"2022","unstructured":"Ammar OA, El-Missiry MA, Othman AI, Amer ME (2022) Melatonin is a potential oncostatic agent to inhibit HepG2 cell proliferation through multiple pathways. Heliyon 8(1):e08837. https:\/\/doi.org\/10.1016\/j.heliyon.2022.e08837","journal-title":"Heliyon"},{"issue":"13","key":"3915_CR108","doi-asserted-by":"publisher","first-page":"3263","DOI":"10.3390\/cancers13133263","volume":"13","author":"A Gonz\u00e1lez","year":"2021","unstructured":"Gonz\u00e1lez A, Alonso-Gonz\u00e1lez C, Gonz\u00e1lez-Gonz\u00e1lez A, Men\u00e9ndez-Men\u00e9ndez J, Cos S, Mart\u00ednez-Campa C (2021) Melatonin as an adjuvant to antiangiogenic cancer treatments. Cancers 13(13):3263","journal-title":"Cancers"},{"issue":"4","key":"3915_CR109","doi-asserted-by":"publisher","first-page":"357","DOI":"10.3390\/antiox9040357","volume":"9","author":"S Gurunathan","year":"2020","unstructured":"Gurunathan S, Jeyaraj M, Kang MH, Kim JH (2020) Melatonin enhances palladium-nanoparticle-induced cytotoxicity and apoptosis in human lung epithelial adenocarcinoma cells A549 and H1229. Antioxidants 9(4):357","journal-title":"Antioxidants"},{"issue":"72","key":"3915_CR110","doi-asserted-by":"publisher","first-page":"110659","DOI":"10.1016\/j.nut.2019.110659","volume":"1","author":"WH Talib","year":"2020","unstructured":"Talib WH (2020) A ketogenic diet combined with melatonin overcomes cisplatin and vincristine drug resistance in breast carcinoma syngraft. Nutrition 1(72):110659","journal-title":"Nutrition"},{"key":"3915_CR111","first-page":"2019","volume":"9","author":"GH Tamarindo","year":"2019","unstructured":"Tamarindo GH, Ribeiro DL, Gobbo MG, Guerra LH, Rahal P, Taboga SR, Gadelha FR, G\u00f3es RM (2019) Melatonin and docosahexaenoic acid decrease proliferation of PNT1A prostate benign cells via modulation of mitochondrial bioenergetics and ROS production. Oxid Med Cell Longev 9:2019","journal-title":"Oxid Med Cell Longev"},{"issue":"1","key":"3915_CR112","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/jpi.12142","volume":"57","author":"R Paroni","year":"2014","unstructured":"Paroni R, Terraneo L, Bonomini F, Finati E, Virgili E, Bianciardi P, Favero G, Fraschini F et al (2014) Antitumour activity of melatonin in a mouse model of human prostate cancer: relationship with hypoxia signalling. J Pineal Res 57(1):43\u201352","journal-title":"J Pineal Res"},{"issue":"5","key":"3915_CR113","first-page":"801","volume":"31","author":"A Zem\u0142a","year":"2017","unstructured":"Zem\u0142a A, Grzegorek I, Dzi\u0119giel P, Jab\u0142o\u0144ska K (2017) Melatonin synergizes the chemotherapeutic effect of cisplatin in ovarian cancer cells independently of MT1 melatonin receptors. In Vivo 31(5):801\u2013809","journal-title":"In Vivo"},{"issue":"12","key":"3915_CR114","doi-asserted-by":"publisher","first-page":"3974","DOI":"10.3390\/ijms19123974","volume":"19","author":"Q Wang","year":"2018","unstructured":"Wang Q, Sun Z, Du L, Xu C, Wang Y, Yang B, He N, Wang J et al (2018) Melatonin sensitizes human colorectal cancer cells to \u03b3-ray ionizing radiation in vitro and in vivo. Int J Mol Sci 19(12):3974","journal-title":"Int J Mol Sci"},{"issue":"1","key":"3915_CR115","doi-asserted-by":"publisher","first-page":"27","DOI":"10.4161\/derm.3.1.14842","volume":"3","author":"K Kleszczy\u0144ski","year":"2011","unstructured":"Kleszczy\u0144ski K, Hardkop LH, Fischer TW (2011) Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator. Dermato-Endocrinology 3(1):27\u201331","journal-title":"Dermato-Endocrinology"},{"issue":"1","key":"3915_CR116","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1038\/s41598-017-01305-2","volume":"7","author":"Z Janjetovic","year":"2017","unstructured":"Janjetovic Z, Jarrett SG, Lee EF, Duprey C, Reiter RJ, Slominski AT (2017) Melatonin and its metabolites protect human melanocytes against UVB-induced damage: involvement of NRF2-mediated pathways. Sci Rep 7(1):1274","journal-title":"Sci Rep"},{"issue":"4","key":"3915_CR117","first-page":"1543","volume":"9","author":"CK Sun","year":"2017","unstructured":"Sun CK, Chen CH, Chang CL, Chiang HJ, Sung PH, Chen KH, Chen YL, Chen SY et al (2017) Melatonin treatment enhances therapeutic effects of exosomes against acute liver ischemia-reperfusion injury. Am J Transl Res 9(4):1543","journal-title":"Am J Transl Res"},{"issue":"3","key":"3915_CR118","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12389","volume":"62","author":"Z Cao","year":"2017","unstructured":"Cao Z, Fang Y, Lu Y, Tan D, Du C, Li Y, Ma Q, Yu J et al (2017) Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome. J Pineal Res 62(3):e12389","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR119","doi-asserted-by":"publisher","first-page":"43","DOI":"10.32794\/mr11250047","volume":"3","author":"RJ Reiter","year":"2020","unstructured":"Reiter RJ, Ma Q, Sharma R (2020) Treatment of Ebola and other infectious diseases: melatonin \u201cgoes viral.\u201d Melatonin Research 3(1):43\u201357","journal-title":"Melatonin Research"},{"key":"3915_CR120","doi-asserted-by":"publisher","first-page":"226","DOI":"10.3389\/fmed.2020.00226","volume":"7","author":"RJ Reiter","year":"2020","unstructured":"Reiter RJ, Abreu-Gonzalez P, Marik PE, Dominguez-Rodriguez A (2020) Therapeutic algorithm for use of melatonin in patients with covid-19. Front Med 7:226. https:\/\/doi.org\/10.3389\/fmed.2020.00226","journal-title":"Front Med"},{"issue":"1","key":"3915_CR121","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3390\/antiox11010140","volume":"11","author":"E Shchetinin","year":"2022","unstructured":"Shchetinin E, Baturin V, Arushanyan E, Bolatchiev A, Bobryshev D (2022) Potential and possible therapeutic effects of melatonin on SARS-CoV-2 infection. Antioxidants 11(1):140","journal-title":"Antioxidants"},{"issue":"4","key":"3915_CR122","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/jpi.12322","volume":"60","author":"Y Zhang","year":"2016","unstructured":"Zhang Y, Li X, Grailer JJ, Wang N, Wang M, Yao J, Zhong R, Gao GF et al (2016) Melatonin alleviates acute lung injury through inhibiting the NLRP3 inflammasome. J Pineal Res 60(4):405\u2013414","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR123","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/s41420-019-0181-7","volume":"5","author":"CS Shi","year":"2019","unstructured":"Shi CS, Nabar NR, Huang NN, Kehrl JH (2019) SARS-coronavirus open reading frame-8b triggers intracellular stress pathways and activates NLRP3 inflammasomes. Cell Death Discovery 5(1):101","journal-title":"Cell Death Discovery"},{"issue":"2","key":"3915_CR124","doi-asserted-by":"publisher","first-page":"132","DOI":"10.2174\/1574886309666140605114614","volume":"10","author":"R Fallah","year":"2015","unstructured":"Fallah R, Shoroki F, Ferdosian F (2015) Safety and efficacy of melatonin in pediatric migraine prophylaxis. Current Drug Safety 10(2):132\u20135","journal-title":"Current Drug Safety"},{"issue":"3","key":"3915_CR125","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3390\/antiox10030376","volume":"10","author":"A Langston-Cox","year":"2021","unstructured":"Langston-Cox A, Marshall SA, Lu D, Palmer KR, Wallace EM (2021) Melatonin for the management of preeclampsia: a review. Antioxidants 10(3):376","journal-title":"Antioxidants"},{"issue":"163","key":"3915_CR126","doi-asserted-by":"publisher","first-page":"105254","DOI":"10.1016\/j.phrs.2020.105254","volume":"1","author":"R Genario","year":"2021","unstructured":"Genario R, Cipolla-Neto J, Bueno AA, Santos HO (2021) Melatonin supplementation in the management of obesity and obesity-associated disorders: a review of physiological mechanisms and clinical applications. Pharmacol Res 1(163):105254","journal-title":"Pharmacol Res"},{"issue":"6","key":"3915_CR127","doi-asserted-by":"publisher","first-page":"2566","DOI":"10.1096\/fj.14-265678","volume":"29","author":"E Cecon","year":"2015","unstructured":"Cecon E, Chen M, Mar\u00e7ola M, Fernandes PA, Jockers R, Markus RP (2015) Amyloid \u03b2 peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway. FASEB J 29(6):2566\u20132582","journal-title":"FASEB J"},{"key":"3915_CR128","first-page":"2019","volume":"10","author":"K Karolczak","year":"2019","unstructured":"Karolczak K, Watala C (2019) The mystery behind the pineal gland: melatonin affects the metabolism of cholesterol. Oxid Med Cell Longev 10:2019","journal-title":"Oxid Med Cell Longev"},{"key":"3915_CR129","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s12020-018-1624-2","volume":"62","author":"TB de Castro","year":"2018","unstructured":"de Castro TB, Bordin-Junior NA, de Almeida EA, de Campos Zuccari DA (2018) Evaluation of melatonin and AFMK levels in women with breast cancer. Endocrine 62:242\u2013249","journal-title":"Endocrine"},{"issue":"4","key":"3915_CR130","doi-asserted-by":"publisher","first-page":"e12564","DOI":"10.1111\/jpi.12564","volume":"66","author":"T Misaka","year":"2019","unstructured":"Misaka T, Yoshihisa A, Yokokawa T, Sato T, Oikawa M, Kobayashi A, Yamaki T, Sugimoto K et al (2019) Plasma levels of melatonin in dilated cardiomyopathy. J Pineal Res 66(4):e12564","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR131","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1210\/endo.141.2.7311","volume":"141","author":"T Wolden-Hanson","year":"2000","unstructured":"Wolden-Hanson T, Mitton DR, McCants RL, Yellon SM, Wilkinson CW, Matsumoto AM, Rasmussen DD (2000) Daily melatonin administration to middle-aged male rats suppresses body weight, intraabdominal adiposity, and plasma leptin and insulin independent of food intake and total body fat. Endocrinology 141(2):487\u2013497","journal-title":"Endocrinology"},{"issue":"12","key":"3915_CR132","doi-asserted-by":"publisher","first-page":"5347","DOI":"10.1210\/en.2003-0693","volume":"144","author":"B Prunet-Marcassus","year":"2003","unstructured":"Prunet-Marcassus B, Desbazeille M, Bros A, Louche K, Delagrange P, Renard P, Casteilla L, P\u00e9nicaud L (2003) Melatonin reduces body weight gain in Sprague Dawley rats with diet-induced obesity. Endocrinology 144(12):5347\u20135352","journal-title":"Endocrinology"},{"issue":"118","key":"3915_CR133","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.physbeh.2013.04.006","volume":"13","author":"MP Terr\u00f3n","year":"2013","unstructured":"Terr\u00f3n MP, Delgado-Ad\u00e1mez J, Pariente JA, Barriga C, Paredes SD, Rodr\u00edguez AB (2013) Melatonin reduces body weight gain and increases nocturnal activity in male Wistar rats. Physiol Behav 13(118):8\u201313","journal-title":"Physiol Behav"},{"issue":"2","key":"3915_CR134","doi-asserted-by":"publisher","first-page":"e12750","DOI":"10.1111\/jpi.12750","volume":"71","author":"EC Marqueze","year":"2021","unstructured":"Marqueze EC, Nogueira LF, Vetter C, Skene DJ, Cipolla-Neto J, Moreno CR (2021) Exogenous melatonin decreases circadian misalignment and body weight among early types. J Pineal Res 71(2):e12750","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR135","doi-asserted-by":"publisher","first-page":"e12399","DOI":"10.1111\/jpi.12399","volume":"62","author":"P Xu","year":"2017","unstructured":"Xu P, Wang J, Hong F, Wang S, Jin X, Xue T, Jia L, Zhai Y (2017) Melatonin prevents obesity through modulation of gut microbiota in mice. J Pineal Res 62(4):e12399","journal-title":"J Pineal Res"},{"issue":"6","key":"3915_CR136","doi-asserted-by":"publisher","first-page":"1193","DOI":"10.1016\/j.neuron.2015.02.016","volume":"85","author":"AV Gandhi","year":"2015","unstructured":"Gandhi AV, Mosser EA, Oikonomou G, Prober DA (2015) Melatonin is required for the circadian regulation of sleep. Neuron 85(6):1193\u20131199","journal-title":"Neuron"},{"issue":"6","key":"3915_CR137","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1080\/01616412.2017.1315864","volume":"39","author":"Z Xie","year":"2017","unstructured":"Xie Z, Chen F, Li WA, Geng X, Li C, Meng X, Feng Y, Liu W et al (2017) A review of sleep disorders and melatonin. Neurol Res 39(6):559\u2013565","journal-title":"Neurol Res"},{"key":"3915_CR138","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1007\/s00429-017-1439-6","volume":"222","author":"KY Ng","year":"2017","unstructured":"Ng KY, Leong MK, Liang H, Paxinos G (2017) Melatonin receptors: distribution in mammalian brain and their respective putative functions. Brain Struct Funct 222:2921\u20132939","journal-title":"Brain Struct Funct"},{"issue":"40","key":"3915_CR139","doi-asserted-by":"publisher","first-page":"31311","DOI":"10.1074\/jbc.M005141200","volume":"275","author":"O Nosjean","year":"2000","unstructured":"Nosjean O, Ferro M, Cog\u00e9 F, Beauverger P, Henlin JM, Lefoulon F, Fauchere JL, Delagrange P et al (2000) Identification of the melatonin-binding site MT3 as the quinone reductase 2. J Biol Chem 275(40):31311\u201331317","journal-title":"J Biol Chem"},{"issue":"5","key":"3915_CR140","doi-asserted-by":"publisher","first-page":"8924","DOI":"10.3390\/ijms14058924","volume":"14","author":"K Shinozuka","year":"2013","unstructured":"Shinozuka K, Staples M, Borlongan CV (2013) Melatonin-based therapeutics for neuroprotection in stroke. Int J Mol Sci 14(5):8924\u20138947","journal-title":"Int J Mol Sci"},{"issue":"2","key":"3915_CR141","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1111\/j.1600-079X.2009.00700.x","volume":"47","author":"M Carretero","year":"2009","unstructured":"Carretero M, Escames G, L\u00f3pez LC, Venegas C, Dayoub JC, Garcia L, Acu\u00f1a-Castroviejo D (2009) Long-term melatonin administration protects brain mitochondria from aging. J Pineal Res 47(2):192\u2013200","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR142","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1111\/j.1749-6632.2009.05352.x","volume":"1199","author":"SV Kabadi","year":"2010","unstructured":"Kabadi SV, Maher TJ (2010) Posttreatment with uridine and melatonin following traumatic brain injury reduces edema in various brain regions in rats. Ann N Y Acad Sci 1199(1):105\u2013113","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"3915_CR143","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1755-5949.2009.00105.x","volume":"15","author":"X Wang","year":"2009","unstructured":"Wang X (2009) The antiapoptotic activity of melatonin in neurodegenerative diseases. CNS Neurosci Ther 15(4):345\u2013357","journal-title":"CNS Neurosci Ther"},{"issue":"9","key":"3915_CR144","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1016\/j.freeradbiomed.2012.01.030","volume":"52","author":"CM Chern","year":"2012","unstructured":"Chern CM, Liao JF, Wang YH, Shen YC (2012) Melatonin ameliorates neural function by promoting endogenous neurogenesis through the MT2 melatonin receptor in ischemic-stroke mice. Free Radical Biol Med 52(9):1634\u20131647","journal-title":"Free Radical Biol Med"},{"issue":"4","key":"3915_CR145","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/j.arcmed.2013.04.002","volume":"44","author":"F Dehghan","year":"2013","unstructured":"Dehghan F, Hadad MK, Asadikram G, Najafipour H, Shahrokhi N (2013) Effect of melatonin on intracranial pressure and brain edema following traumatic brain injury: role of oxidative stresses. Arch Med Res 44(4):251\u2013258","journal-title":"Arch Med Res"},{"issue":"3","key":"3915_CR146","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1111\/jpi.12360","volume":"61","author":"RJ Reiter","year":"2016","unstructured":"Reiter RJ, Mayo JC, Tan DX, Sainz RM, Alatorre-Jimenez M, Qin L (2016) Melatonin as an antioxidant: under promises but over delivers. J Pineal Res 61(3):253\u2013278","journal-title":"J Pineal Res"},{"issue":"5","key":"3915_CR147","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1016\/j.biochi.2011.02.007","volume":"93","author":"A Mishra","year":"2011","unstructured":"Mishra A, Paul S, Swarnakar S (2011) Downregulation of matrix metalloproteinase-9 by melatonin during prevention of alcohol-induced liver injury in mice. Biochimie 93(5):854\u2013866","journal-title":"Biochimie"},{"issue":"1\u20133","key":"3915_CR148","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.ejphar.2009.06.044","volume":"616","author":"S Hu","year":"2009","unstructured":"Hu S, Yin S, Jiang X, Huang D, Shen G (2009) Melatonin protects against alcoholic liver injury by attenuating oxidative stress, inflammatory response, and apoptosis. Eur J Pharmacol 616(1\u20133):287\u2013292","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"3915_CR149","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1136\/oemed-2018-105273","volume":"76","author":"F Wang","year":"2019","unstructured":"Wang F, Zhang L, Wu S, Li W, Sun M, Feng W, Ding D, Wong SY et al (2019) Night shift work and abnormal liver function: is non-alcohol fatty liver a necessary mediator? Occup Environ Med 76(2):83\u201389","journal-title":"Occup Environ Med"},{"issue":"1","key":"3915_CR150","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/07420528.2018.1516672","volume":"36","author":"H Okauchi","year":"2019","unstructured":"Okauchi H, Hashimoto C, Nakao R, Oishi K (2019) Timing of food intake is more potent than habitual voluntary exercise to prevent diet-induced obesity in mice. Chronobiol Int 36(1):57\u201374","journal-title":"Chronobiol Int"},{"key":"3915_CR151","doi-asserted-by":"crossref","unstructured":"Masarone M, Rosato V, Dallio M et al (2018) Role of Oxidative Stress in Pathophysiology of Nonalcoholic Fatty Liver Disease. Oxidative Med Cell Longev 2018(9547613):14","DOI":"10.1155\/2018\/9547613"},{"issue":"4","key":"3915_CR152","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12404","volume":"62","author":"N Das","year":"2017","unstructured":"Das N, Mandala A, Naaz S, Giri S, Jain M, Bandyopadhyay D, Reiter RJ, Roy SS (2017) Melatonin protects against lipid-induced mitochondrial dysfunction in hepatocytes and inhibits stellate cell activation during hepatic fibrosis in mice. J Pineal Res 62(4):e12404","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR153","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1002\/jgh3.12055","volume":"2","author":"S Bona","year":"2018","unstructured":"Bona S, Rodrigues G, Moreira AJ, Di Naso FC, Dias AS, Da Silveira TR, Marroni CA, Marroni NP (2018) Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride. JGH Open 2(4):117\u2013123","journal-title":"JGH Open"},{"key":"3915_CR154","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1007\/s11596-018-1871-8","volume":"38","author":"YR Wang","year":"2018","unstructured":"Wang YR, Hong RT, Xie YY, Xu JM (2018) Melatonin ameliorates liver fibrosis induced by carbon tetrachloride in rats via inhibiting TGF-\u03b21\/Smad signaling pathway. Curr Med Sci 38:236\u2013244","journal-title":"Curr Med Sci"},{"issue":"4","key":"3915_CR155","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1111\/jpi.12319","volume":"60","author":"JW Kang","year":"2016","unstructured":"Kang JW, Hong JM, Lee SM (2016) Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. J Pineal Res 60(4):383\u2013393","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR156","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.trsl.2014.10.003","volume":"165","author":"I Crespo","year":"2015","unstructured":"Crespo I, San-Miguel B, Fern\u00e1ndez A, De Urbina JO, Gonz\u00e1lez-Gallego J, Tu\u00f1\u00f3n MJ (2015) Melatonin limits the expression of profibrogenic genes and ameliorates the progression of hepatic fibrosis in mice. Transl Res 165(2):346\u2013357","journal-title":"Transl Res"},{"issue":"12","key":"3915_CR157","doi-asserted-by":"publisher","first-page":"1452","DOI":"10.3748\/wjg.15.1452","volume":"15","author":"RT Hong","year":"2009","unstructured":"Hong RT, Xu JM, Mei Q (2009) Melatonin ameliorates experimental hepatic fibrosis induced by carbon tetrachloride in rats. World J Gastroenterol WJG 15(12):1452","journal-title":"World J Gastroenterol WJG"},{"issue":"11","key":"3915_CR158","doi-asserted-by":"publisher","first-page":"103","DOI":"10.3389\/fphys.2020.00103","volume":"11","author":"G Favero","year":"2020","unstructured":"Favero G, Franco C, Stacchiotti A, Rodella LF, Rezzani R (2020) Sirtuin1 role in the melatonin protective effects against obesity-related heart injury. Front Physiol 11(11):103","journal-title":"Front Physiol"},{"issue":"5","key":"3915_CR159","first-page":"530","volume":"33","author":"B Cimen","year":"2017","unstructured":"Cimen B, Uz A, Cetin I, Cimen L, Cetin A (2017) Melatonin supplementation ameliorates energy charge and oxidative stress induced by acute exercise in rat heart tissue. Acta Cardiologica Sinica 33(5):530","journal-title":"Acta Cardiologica Sinica"},{"issue":"3","key":"3915_CR160","first-page":"355","volume":"24","author":"R Vazan","year":"2005","unstructured":"Vazan R, Pancza D, B\u00e9der I, Styk J (2005) Ischemia-reperfusion injury-antiarrhythmic effect of melatonin associated with reduced recovering of contractility. Gen Physiol Biophys 24(3):355","journal-title":"Gen Physiol Biophys"},{"issue":"2","key":"3915_CR161","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1111\/jpi.12054","volume":"55","author":"A\u00d6 \u015eehirli","year":"2013","unstructured":"\u015eehirli A\u00d6, Koyun D, Tetik \u015e, \u00d6zsavc\u0131 D, Yi\u011finer \u00d6, \u00c7etinel \u015e, Tok OE, Kaya Z et al (2013) Melatonin protects against ischemic heart failure in rats. J Pineal Res 55(2):138\u2013148","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR162","first-page":"29","volume":"62","author":"J Drobnik","year":"2011","unstructured":"Drobnik J, Slotwinska D, Olczak S, Tosik D, Pieniazek A, Matczak K, Koceva-Chyla A, Szczepanowska A (2011) Pharmacological doses of melatonin reduce the glycosaminoglycan level within the infarcted heart scar. J Physiol Pharmacol 62(1):29","journal-title":"J Physiol Pharmacol"},{"issue":"2","key":"3915_CR163","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1016\/j.bbadis.2017.11.023","volume":"1864","author":"LM Yu","year":"2018","unstructured":"Yu LM, Di WC, Dong X, Li Z, Zhang Y, Xue XD, Xu YL, Zhang J et al (2018) Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation. Biochim Biophys Acta BBA Mol Basis Dis 1864(2):563\u201378","journal-title":"Biochim Biophys Acta BBA Mol Basis Dis"},{"issue":"3","key":"3915_CR164","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/jpi.12070","volume":"55","author":"Y Yang","year":"2013","unstructured":"Yang Y, Duan W, Jin Z, Yi W, Yan J, Zhang S, Wang N, Liang Z et al (2013) JAK2\/STAT3 activation by melatonin attenuates the mitochondrial oxidative damage induced by myocardial ischemia\/reperfusion injury. J Pineal Res 55(3):275\u2013286","journal-title":"J Pineal Res"},{"key":"3915_CR165","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1007\/s12192-017-0827-4","volume":"23","author":"H Zhu","year":"2018","unstructured":"Zhu H, Jin Q, Li Y, Ma Q, Wang J, Li D, Zhou H, Chen Y (2018) Melatonin protected cardiac microvascular endothelial cells against oxidative stress injury via suppression of IP3R-[Ca2+]c\/VDAC-[Ca2+]m axis by activation of MAPK\/ERK signaling pathway. Cell Stress Chaperones 23:101\u2013113","journal-title":"Cell Stress Chaperones"},{"issue":"1","key":"3915_CR166","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.tox.2010.04.008","volume":"278","author":"D Bonnefont-Rousselot","year":"2010","unstructured":"Bonnefont-Rousselot D, Collin F (2010) Melatonin: action as antioxidant and potential applications in human disease and aging. Toxicology 278(1):55\u201367","journal-title":"Toxicology"},{"issue":"2","key":"3915_CR167","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.mce.2012.01.004","volume":"351","author":"RM Slominski","year":"2012","unstructured":"Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT (2012) Melatonin membrane receptors in peripheral tissues: distribution and functions. Mol Cell Endocrinol 351(2):152\u2013166","journal-title":"Mol Cell Endocrinol"},{"issue":"11","key":"3915_CR168","doi-asserted-by":"publisher","first-page":"1661","DOI":"10.1517\/13543784.2012.714771","volume":"21","author":"L Paulis","year":"2012","unstructured":"Paulis L, Simko F, Laudon M (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs 21(11):1661\u20131678","journal-title":"Expert Opin Investig Drugs"},{"issue":"7","key":"3915_CR169","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1038\/sj.bjp.0701511","volume":"122","author":"KN Ting","year":"1997","unstructured":"Ting KN, Dunn WR, Davies DJ, Sugden D, Delagrange P, Guardiola-Lema\u00eetre B, Scalbert E, Wilson VG (1997) Studies on the vasoconstrictor action of melatonin and putative melatonin receptor ligands in the tail artery of juvenile Wistar rats. Br J Pharmacol 122(7):1299\u20131306","journal-title":"Br J Pharmacol"},{"issue":"8","key":"3915_CR170","doi-asserted-by":"publisher","first-page":"1369","DOI":"10.1097\/00004872-200108000-00004","volume":"19","author":"H Girouard","year":"2001","unstructured":"Girouard H, Chulak C, Lejossec M, Lamontagne D, de Champlain J (2001) Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats. J Hypertens 19(8):1369\u20131377","journal-title":"J Hypertens"},{"key":"3915_CR171","doi-asserted-by":"publisher","unstructured":"Simko F, Pechanova O, Repova Bednarova K, Krajcirovicova K, Celec P, Kamodyova N, Zorad S, Kucharska J, Gvozdjakova A, Adamcova M, Paulis L (2014) Hypertension and cardiovascular remodelling in rats exposed to continuous light: Protection by ACE-inhibition and melatonin. Mediat Inflamm 2014(703175):10. https:\/\/doi.org\/10.1155\/2014\/703175","DOI":"10.1155\/2014\/703175"},{"issue":"3","key":"3915_CR172","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1111\/j.1600-079X.2010.00747.x","volume":"48","author":"JB Hoppe","year":"2010","unstructured":"Hoppe JB, Frozza RL, Horn AP, Comiran RA, Bernardi A, Campos MM, Battastini AM, Salbego C (2010) Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation. J Pineal Res 48(3):230\u2013238","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR173","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/S0165-2478(03)00068-3","volume":"88","author":"YM Tian","year":"2003","unstructured":"Tian YM, Zhang GY, Dai YR (2003) Melatonin rejuvenates degenerated thymus and redresses peripheral immune functions in aged mice. Immunol Lett 88(2):101\u2013104","journal-title":"Immunol Lett"},{"issue":"2","key":"3915_CR174","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/j.1600-079X.2008.00570.x","volume":"45","author":"J Zhou","year":"2008","unstructured":"Zhou J, Zhang S, Zhao X, Wei T (2008) Melatonin impairs NADPH oxidase assembly and decreases superoxide anion production in microglia exposed to amyloid-\u03b21\u201342. J Pineal Res 45(2):157\u2013165","journal-title":"J Pineal Res"},{"key":"3915_CR175","doi-asserted-by":"publisher","unstructured":"Zhou LL, Wei W, Si JF, Yuan DP\u00a0(2010) Regulatory Effect of Melatonin on Cytokine Disturbances in the Pristane-Induced Lupus Mice. Mediat Inflamm 2010(951210):7. https:\/\/doi.org\/10.1155\/2010\/951210","DOI":"10.1155\/2010\/951210"},{"issue":"186","key":"3915_CR176","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.jphotobiol.2018.07.003","volume":"1","author":"HA El-Bakry","year":"2018","unstructured":"El-Bakry HA, Ismail IA, Soliman SS (2018) Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1\/Nrf2 and P53\/Bax pathways. J Photochem Photobiol B 1(186):69\u201380","journal-title":"J Photochem Photobiol B"},{"issue":"2","key":"3915_CR177","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12547","volume":"66","author":"Y Xia","year":"2019","unstructured":"Xia Y, Chen S, Zeng S, Zhao Y, Zhu C, Deng B, Zhu G, Yin Y et al (2019) Melatonin in macrophage biology: current understanding and future perspectives. J Pineal Res 66(2):e12547","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR178","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.3390\/ijms16011030","volume":"16","author":"E Walecka-Kapica","year":"2015","unstructured":"Walecka-Kapica E, Chojnacki J, St\u0119pie\u0144 A, Wachowska-Kelly P, Klupi\u0144ska G, Chojnacki C (2015) Melatonin and female hormone secretion in postmenopausal overweight women. Int J Mol Sci 16(1):1030\u20131042","journal-title":"Int J Mol Sci"},{"issue":"9","key":"3915_CR179","doi-asserted-by":"publisher","first-page":"2802","DOI":"10.3390\/ijms19092802","volume":"19","author":"G Carlomagno","year":"2018","unstructured":"Carlomagno G, Minini M, Tilotta M, Unfer V (2018) From implantation to birth: insight into molecular melatonin functions. Int J Mol Sci 19(9):2802","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3915_CR180","doi-asserted-by":"publisher","first-page":"NP105","DOI":"10.1177\/0890334415625217","volume":"32","author":"D Katzer","year":"2016","unstructured":"Katzer D, Pauli L, Mueller A, Reutter H, Reinsberg J, Fimmers R, Bartmann P, Bagci S (2016) Melatonin concentrations and antioxidative capacity of human breast milk according to gestational age and the time of day. J Hum Lact. 32(4):NP105-10","journal-title":"J Hum Lact."},{"issue":"7","key":"3915_CR181","first-page":"37","volume":"2","author":"R Dumbell","year":"2016","unstructured":"Dumbell R, Matveeva O, Oster H (2016) Circadian clocks, stress, and immunity. Front Endocrinol 2(7):37","journal-title":"Front Endocrinol"},{"issue":"4","key":"3915_CR182","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1016\/j.jpeds.2013.04.052","volume":"163","author":"N Rochow","year":"2013","unstructured":"Rochow N, Fusch G, Choi A, Chessell L, Elliott L, McDonald K, Kuiper E, Purcha M et al (2013) Target fortification of breast milk with fat, protein, and carbohydrates for preterm infants. J Pediatr 163(4):1001\u20131007","journal-title":"J Pediatr"},{"issue":"2","key":"3915_CR183","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12715","volume":"78","author":"GC Man","year":"2017","unstructured":"Man GC, Zhang T, Chen X, Wang J, Wu F, Liu Y, Wang CC, Cheong Y et al (2017) The regulations and role of circadian clock and melatonin in uterine receptivity and pregnancy\u2014an immunological perspective. Am J Reprod Immunol 78(2):e12715","journal-title":"Am J Reprod Immunol"},{"issue":"904","key":"3915_CR184","doi-asserted-by":"publisher","first-page":"174193","DOI":"10.1016\/j.ejphar.2021.174193","volume":"5","author":"A Hosseini","year":"2021","unstructured":"Hosseini A, Ghaleh HE, Aghamollaei H, Ramandi MF, Alishiri G, Shahriary A, Hassanpour K, Tat M et al (2021) Evaluation of Th1 and Th2 mediated cellular and humoral immunity in patients with COVID-19 following the use of melatonin as an adjunctive treatment. Eur J Pharmacol 5(904):174193","journal-title":"Eur J Pharmacol"},{"issue":"4","key":"3915_CR185","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1177\/0748233712472521","volume":"31","author":"S \u0130lhan","year":"2015","unstructured":"\u0130lhan S, Ate\u015f\u015fahin D, Ate\u015f\u015fahin A, Mutlu E, Onat E, \u015eahna E (2015) 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced hypertension: the beneficial effects of melatonin. Toxicol Ind Health 31(4):298\u2013303","journal-title":"Toxicol Ind Health"},{"issue":"1","key":"3915_CR186","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/hr.2009.174","volume":"33","author":"T Rechci\u0144ski","year":"2010","unstructured":"Rechci\u0144ski T, Trzos E, Wierzbowska-Drabik K, Krzemi\u0144ska-Paku\u0142a M, Kurpesa M (2010) Melatonin for nondippers with coronary artery disease: assessment of blood pressure profile and heart rate variability. Hypertens Res 33(1):56\u201361","journal-title":"Hypertens Res"},{"issue":"2","key":"3915_CR187","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3109\/09513590.2013.849238","volume":"30","author":"RJ Reiter","year":"2014","unstructured":"Reiter RJ, Tan DX, Tamura H, Cruz MH, Fuentes-Broto L (2014) Clinical relevance of melatonin in ovarian and placental physiology: a review. Gynecol Endocrinol 30(2):83\u201389","journal-title":"Gynecol Endocrinol"},{"issue":"2","key":"3915_CR188","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.fertnstert.2014.06.014","volume":"102","author":"RJ Reiter","year":"2014","unstructured":"Reiter RJ, Tamura H, Tan DX, Xu XY (2014) Melatonin and the circadian system: contributions to successful female reproduction. Fertil Steril 102(2):321\u2013328","journal-title":"Fertil Steril"},{"issue":"1","key":"3915_CR189","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1093\/humrep\/10.1.50","volume":"10","author":"SM Yie","year":"1995","unstructured":"Yie SM, Brown GM, Liu GY, Collins JA, Daya S, Hughes EG, Foster WG, Younglai EV (1995) Melatonin and steroids in human pre-ovulatory follicular fluid: seasonal variations and granulosa cell steroid production. Hum Reprod 10(1):50\u201355","journal-title":"Hum Reprod"},{"issue":"02","key":"3915_CR190","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1055\/s-0029-1211736","volume":"105","author":"HJ Schaeffer","year":"1997","unstructured":"Schaeffer HJ, Sirotkin AV (1997) Melatonin and serotonin regulate the release of insulin-like growth factor-I, oxytocin and progesterone by cultured human granulosa cells. Exp Clin Endocrinol Diabetes 105(02):109\u2013112","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"5","key":"3915_CR191","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1159\/000184277","volume":"43","author":"Y Okatani","year":"1995","unstructured":"Okatani Y, Sagara Y (1995) Enhanced nocturnal melatonin secretion in women with functional secondary amenorrhea: relationship to opioid system and endogenous estrogen levels. Horm Res Paediatr 43(5):194\u2013199","journal-title":"Horm Res Paediatr"},{"issue":"1","key":"3915_CR192","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1111\/jpi.12236","volume":"59","author":"A Soliman","year":"2015","unstructured":"Soliman A, Lacasse AA, Lanoix D, Sagrillo-Fagundes L, Boulard V, Vaillancourt C (2015) Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation. J Pineal Res 59(1):38\u201346","journal-title":"J Pineal Res"},{"issue":"4","key":"3915_CR193","doi-asserted-by":"publisher","first-page":"e12520","DOI":"10.1111\/jpi.12520","volume":"65","author":"L Sagrillo-Fagundes","year":"2018","unstructured":"Sagrillo-Fagundes L, Assun\u00e7\u00e3o Salustiano EM, Ruano R, Markus RP, Vaillancourt C (2018) Melatonin modulates autophagy and inflammation protecting human placental trophoblast from hypoxia\/reoxygenation. J Pineal Res 65(4):e12520","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR194","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1196\/annals.1356.026","volume":"1057","author":"B D\u00edaz L\u00f3pez","year":"2005","unstructured":"D\u00edaz L\u00f3pez B, Rodr\u00edguez ED, Urquijo C, Alvarez CF (2005) Melatonin influences on the neuroendocrine-reproductive axis. Ann N Y Acad Sci 1057(1):337\u2013364","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"3915_CR195","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1159\/000516148","volume":"112","author":"J Cipolla-Neto","year":"2022","unstructured":"Cipolla-Neto J, Amaral FG, Soares JM Jr, Gallo CC, Furtado A, Cavaco JE, Gon\u00e7alves I, Santos CR et al (2022) The crosstalk between melatonin and sex steroid hormones. Neuroendocrinology 112(2):115\u2013129","journal-title":"Neuroendocrinology"},{"issue":"2","key":"3915_CR196","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3390\/molecules23020447","volume":"23","author":"K Yu","year":"2018","unstructured":"Yu K, Deng SL, Sun TC, Li YY, Liu YX (2018) Melatonin regulates the synthesis of steroid hormones on male reproduction: a review. Molecules 23(2):447","journal-title":"Molecules"},{"issue":"8094","key":"3915_CR197","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1016\/S0140-6736(78)92591-6","volume":"312","author":"M Cohen","year":"1978","unstructured":"Cohen M, Lippman M, Chabner B (1978) Role of pineal gland in aetiology and treatment of breast cancer. The Lancet 312(8094):814\u2013816","journal-title":"The Lancet"},{"key":"3915_CR198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s41606-016-0006-z","volume":"1","author":"M Comas","year":"2017","unstructured":"Comas M, Gordon CJ, Oliver BG, Stow NW, King G, Sharma P, Ammit AJ, Grunstein RR et al (2017) A circadian based inflammatory response\u2013implications for respiratory disease and treatment. Sleep Sci Pract 1:1\u20139","journal-title":"Sleep Sci Pract"},{"issue":"4","key":"3915_CR199","doi-asserted-by":"publisher","first-page":"8638","DOI":"10.3390\/ijms14048638","volume":"14","author":"A Carrillo-Vico","year":"2013","unstructured":"Carrillo-Vico A, Lardone PJ, \u00c1lvarez-S\u00e1nchez N, Rodr\u00edguez-Rodr\u00edguez A, Guerrero JM (2013) Melatonin: buffering the immune system. Int J Mol Sci 14(4):8638\u20138683","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3915_CR200","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41419-019-1556-7","volume":"10","author":"A Tarocco","year":"2019","unstructured":"Tarocco A, Caroccia N, Morciano G, Wieckowski MR, Ancora G, Garani G, Pinton P (2019) Melatonin as a master regulator of cell death and inflammation: molecular mechanisms and clinical implications for newborn care. Cell Death Dis 10(4):1\u20132","journal-title":"Cell Death Dis"},{"key":"3915_CR201","doi-asserted-by":"publisher","unstructured":"Espino Javier, Pariente Jos\u00e9 A, Rodr\u00edguez Ana B (2012) Oxidative stress and immunosenescence: Therapeutic effects of melatonin. Oxidative Med Cell Longev 2012(670294):9. https:\/\/doi.org\/10.1155\/2012\/670294","DOI":"10.1155\/2012\/670294"},{"issue":"1","key":"3915_CR202","doi-asserted-by":"publisher","first-page":"78","DOI":"10.32794\/mr11250005","volume":"1","author":"R Hardeland","year":"2018","unstructured":"Hardeland R (2018) Melatonin and retinoid orphan receptors: demand for new interpretations after their exclusion as nuclear melatonin receptors. Melatonin Res 1(1):78\u201393","journal-title":"Melatonin Res"},{"key":"3915_CR203","first-page":"83","volume":"15","author":"J Sreenivasan","year":"2008","unstructured":"Sreenivasan J, Ramachandran H (2008) The effect of ethanol on the developing chick brain. Ann Neurosci 15:83","journal-title":"Ann Neurosci"},{"issue":"16","key":"3915_CR204","doi-asserted-by":"publisher","first-page":"3239","DOI":"10.1111\/bph.14083","volume":"175","author":"RP Markus","year":"2018","unstructured":"Markus RP, Fernandes PA, Kinker GS, da Silveira C-M, Mar\u00e7ola M (2018) Immune-pineal axis\u2013acute inflammatory responses coordinate melatonin synthesis by pinealocytes and phagocytes. Br J Pharmacol 175(16):3239\u20133250","journal-title":"Br J Pharmacol"},{"issue":"1","key":"3915_CR205","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1016\/j.intimp.2014.06.038","volume":"22","author":"DK Vishwas","year":"2014","unstructured":"Vishwas DK, Haldar C (2014) MT1 receptor expression and AA-NAT activity in lymphatic tissue following melatonin administration in male golden hamster. Int Immunopharmacol 22(1):258\u2013265","journal-title":"Int Immunopharmacol"},{"key":"3915_CR206","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/s11010-019-03617-5","volume":"462","author":"S Bhattacharya","year":"2019","unstructured":"Bhattacharya S, Patel KK, Dehari D, Agrawal AK, Singh S (2019) Melatonin and its ubiquitous anticancer effects. Mol Cell Biochem 462:133\u2013155","journal-title":"Mol Cell Biochem"},{"key":"3915_CR207","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1742-4933-2-17","volume":"2","author":"V Srinivasan","year":"2005","unstructured":"Srinivasan V, Maestroni GJ, Cardinali DP, Esquifino AI, Perumal SP, Miller SC (2005) Melatonin, immune function and aging. Immun Ageing 2:1\u201310","journal-title":"Immun Ageing"},{"key":"3915_CR208","doi-asserted-by":"crossref","unstructured":"Srinivasa V, Gobbi G, Shillcutt SD, Suzen S (eds) (2014) Melatonin: therapeutic value and neuroprotection. Taylor & Francis, BocaRaton, FL","DOI":"10.1201\/b17448"},{"issue":"6","key":"3915_CR209","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/S0891-5849(00)00447-0","volume":"30","author":"V Raghavendra","year":"2001","unstructured":"Raghavendra V, Kulkarni SK (2001) Possible antioxidant mechanism in melatonin reversal of aging and chronic ethanol-induced amnesia in plus-maze and passive avoidance memory tasks. Free Radical Biol Med 30(6):595\u2013602","journal-title":"Free Radical Biol Med"},{"issue":"8","key":"3915_CR210","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1182\/blood-2016-10-747303","volume":"130","author":"O Havranek","year":"2017","unstructured":"Havranek O, Xu J, K\u00f6hrer S, Wang Z, Becker L, Comer JM, Henderson J, Ma W et al (2017) Tonic B-cell receptor signaling in diffuse large B-cell lymphoma. Blood. 130(8):995\u20131006","journal-title":"Blood."},{"issue":"1","key":"3915_CR211","doi-asserted-by":"publisher","first-page":"e12409","DOI":"10.1111\/jpi.12409","volume":"63","author":"V Braz\u00e3o","year":"2017","unstructured":"Braz\u00e3o V, Santello FH, Colato RP, Mazotti TT, Tazinafo LF, Toldo MP, do Vale GT, Tirapelli CR et al (2017) Melatonin: antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection. J Pineal Res 63(1):e12409","journal-title":"J Pineal Res"},{"key":"3915_CR212","doi-asserted-by":"publisher","first-page":"4082","DOI":"10.1007\/s12035-020-02017-x","volume":"57","author":"N \u00c1lvarez-S\u00e1nchez","year":"2020","unstructured":"\u00c1lvarez-S\u00e1nchez N, Cruz-Chamorro I, \u00c1lvarez-L\u00f3pez AI, L\u00f3pez-Gonz\u00e1lez A, Lacalle Remigio JR, Lardone PJ, Guerrero JM, Mart\u00ednez-L\u00f3pez A et al (2020) Seasonal variations in macrophages\/microglia underlie changes in the mouse model of multiple sclerosis severity. Mol Neurobiol 57:4082\u20134089","journal-title":"Mol Neurobiol"},{"issue":"6","key":"3915_CR213","doi-asserted-by":"publisher","first-page":"1338","DOI":"10.1016\/j.cell.2015.08.025","volume":"162","author":"MF Farez","year":"2015","unstructured":"Farez MF, Mascanfroni ID, M\u00e9ndez-Huergo SP, Yeste A, Murugaiyan G, Garo LP, Aguirre ME, Patel B et al (2015) Melatonin contributes to the seasonality of multiple sclerosis relapses. Cell 162(6):1338\u20131352","journal-title":"Cell"},{"issue":"7","key":"3915_CR214","doi-asserted-by":"publisher","first-page":"760","DOI":"10.3390\/cells8070760","volume":"8","author":"SU Rehman","year":"2019","unstructured":"Rehman SU, Ikram M, Ullah N, Alam SI, Park HY, Badshah H, Choe K, Ok KM (2019) Neurological enhancement effects of melatonin against brain injury-induced oxidative stress, neuroinflammation, and neurodegeneration via AMPK\/CREB signaling. Cells 8(7):760","journal-title":"Cells"},{"issue":"10","key":"3915_CR215","doi-asserted-by":"publisher","first-page":"750","DOI":"10.3389\/fendo.2019.00750","volume":"5","author":"TD Farias","year":"2019","unstructured":"Farias TD, Cruz MM, Sa RC, Severi I, Perugini J, Senzacqua M, Cerutti SM, Giordano A et al (2019) Melatonin supplementation decreases hypertrophic obesity and inflammation induced by high-fat diet in mice. Front Endocrinol 5(10):750","journal-title":"Front Endocrinol"},{"issue":"1","key":"3915_CR216","doi-asserted-by":"publisher","first-page":"47","DOI":"10.3390\/antiox10010047","volume":"10","author":"P Wongchitrat","year":"2021","unstructured":"Wongchitrat P, Shukla M, Sharma R, Govitrapong P, Reiter RJ (2021) Role of melatonin on virus-induced neuropathogenesis\u2014a concomitant therapeutic strategy to understand SARS-CoV-2 infection. Antioxidants 10(1):47","journal-title":"Antioxidants"},{"issue":"3","key":"3915_CR217","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1111\/j.1600-079X.2012.00995.x","volume":"53","author":"A Laliena","year":"2012","unstructured":"Laliena A, Miguel BS, Crespo I, Alvarez M, Gonz\u00e1lez-Gallego J, Tu\u00f1\u00f3n MJ (2012) Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin. J Pineal Res 53(3):270\u2013278","journal-title":"J Pineal Res"},{"issue":"1","key":"3915_CR218","doi-asserted-by":"publisher","first-page":"35165","DOI":"10.1038\/srep35165","volume":"6","author":"C Song","year":"2016","unstructured":"Song C, Peng W, Yin S, Zhao J, Fu B, Zhang J, Mao T, Wu H et al (2016) Melatonin improves age-induced fertility decline and attenuates ovarian mitochondrial oxidative stress in mice. Sci Rep 6(1):35165","journal-title":"Sci Rep"},{"key":"3915_CR219","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11357-014-9707-3","volume":"36","author":"RA Kireev","year":"2014","unstructured":"Kireev RA, Vara E, Vi\u00f1a J, Tresguerres JA (2014) Melatonin and oestrogen treatments were able to improve neuroinflammation and apoptotic processes in dentate gyrus of old ovariectomized female rats. Age 36:1\u20135","journal-title":"Age"},{"issue":"19","key":"3915_CR220","doi-asserted-by":"publisher","first-page":"7174","DOI":"10.3390\/ijms21197174","volume":"21","author":"F Luo","year":"2020","unstructured":"Luo F, Sandhu AF, Rungratanawanich W, Williams GE, Akbar M, Zhou S, Song BJ, Wang X (2020) Melatonin and autophagy in aging-related neurodegenerative diseases. Int J Mol Sci 21(19):7174","journal-title":"Int J Mol Sci"},{"issue":"7","key":"3915_CR221","doi-asserted-by":"publisher","first-page":"3779","DOI":"10.3390\/ijms23073779","volume":"23","author":"L Wang","year":"2022","unstructured":"Wang L, Wang C, Choi WS (2022) Use of melatonin in cancer treatment: where are we? Int J Mol Sci 23(7):3779","journal-title":"Int J Mol Sci"},{"issue":"12","key":"3915_CR222","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.2174\/1871520618666180131112304","volume":"18","author":"J Colombo","year":"2018","unstructured":"Colombo J, Jardim-Perassi BV, Ferreira JP, Braga CZ, Sonehara NM, J\u00fanior RP, Moschetta MG, Girol AP et al (2018) Melatonin differentially modulates NF-\u043aB expression in breast and liver cancer cells. Anticancer Agents Med Chem. 18(12):1688\u201394","journal-title":"Anticancer Agents Med Chem."},{"issue":"6","key":"3915_CR223","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1016\/j.hbpd.2021.04.001","volume":"20","author":"Y Gao","year":"2021","unstructured":"Gao Y, Li ZT, Jin L, Lin J, Fan ZL, Zeng Z, Huang HF (2021) Melatonin attenuates hepatic ischemia-reperfusion injury in rats by inhibiting NF-\u03baB signaling pathway. Hepatobiliary Pancreat Dis Int 20(6):551\u2013560","journal-title":"Hepatobiliary Pancreat Dis Int"},{"issue":"1","key":"3915_CR224","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12885-015-1032-4","volume":"15","author":"LG Chuffa","year":"2015","unstructured":"Chuffa LG, Fioruci-Fontanelli BA, Mendes LO, Ferreira Seiva FR, Martinez M, F\u00e1varo WJ, Domeniconi RF, Pinheiro PF et al (2015) Melatonin attenuates the TLR4-mediated inflammatory response through MyD88-and TRIF-dependent signaling pathways in an in vivo model of ovarian cancer. BMC Cancer. 15(1):1\u20133","journal-title":"BMC Cancer."},{"issue":"2","key":"3915_CR225","doi-asserted-by":"publisher","first-page":"129","DOI":"10.3390\/pharmaceutics13020129","volume":"13","author":"DM Kopustinskiene","year":"2021","unstructured":"Kopustinskiene DM, Bernatoniene J (2021) Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease. Pharmaceutics 13(2):129","journal-title":"Pharmaceutics"},{"issue":"1","key":"3915_CR226","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s12950-021-00269-5","volume":"18","author":"A Rahbarghazi","year":"2021","unstructured":"Rahbarghazi A, Siahkouhian M, Rahbarghazi R, Ahmadi M, Bolboli L, Keyhanmanesh R, Mahdipour M, Rajabi H (2021) Role of melatonin in the angiogenesis potential; highlights on the cardiovascular disease. J Inflamm 18(1):1","journal-title":"J Inflamm"},{"issue":"907","key":"3915_CR227","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.174365","volume":"15","author":"Q Mu","year":"2021","unstructured":"Mu Q, Najafi M (2021) Modulation of the tumor microenvironment (TME) by melatonin. Eur J Pharmacol 15(907):174365","journal-title":"Eur J Pharmacol"},{"issue":"12","key":"3915_CR228","doi-asserted-by":"publisher","first-page":"4521","DOI":"10.3390\/ijms21124521","volume":"21","author":"EK Elmahallawy","year":"2020","unstructured":"Elmahallawy EK, Mohamed Y, Abdo W, Yanai T (2020) Melatonin and mesenchymal stem cells as a key for functional integrity for liver cancer treatment. Int J Mol Sci 21(12):4521","journal-title":"Int J Mol Sci"},{"issue":"5","key":"3915_CR229","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1002\/ar.21361","volume":"294","author":"H Liu","year":"2011","unstructured":"Liu H, Xu L, Wei JE, Xie MR, Wang SE, Zhou RX (2011) Role of CD4+ CD25+ regulatory T cells in melatonin-mediated inhibition of murine gastric cancer cell growth in vivo and in vitro. Anat Rec (Hoboken) 294(5):781\u2013788","journal-title":"Anat Rec (Hoboken)"},{"issue":"3","key":"3915_CR230","first-page":"236","volume":"21","author":"A Aliasgharzadeh","year":"2019","unstructured":"Aliasgharzadeh A, Farhood B, Amini P, Saffar H, Motevaseli E, Rezapoor S, Nouruzi F, Shabeeb D et al (2019) Melatonin attenuates upregulation of Duox1, and Duox2 and protects against lung injury following chest irradiation in rats. Cell J (Yakhteh) 21(3):236","journal-title":"Cell J (Yakhteh)"},{"key":"3915_CR231","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1208\/s12249-021-01941-y","volume":"22","author":"P Uthaiwat","year":"2021","unstructured":"Uthaiwat P, Priprem A, Chio-Srichan S, Settasatian C, Lee YC, Mahakunakorn P, Boonsiri P, Leelayuwat C et al (2021) Oral administration of melatonin or succinyl melatonin niosome gel benefits 5-FU-induced small intestinal mucositis treatment in mice. AAPS PharmSciTech 22:1\u20131","journal-title":"AAPS PharmSciTech"},{"issue":"4","key":"3915_CR232","doi-asserted-by":"publisher","first-page":"84","DOI":"10.3390\/biology8040084","volume":"8","author":"JY Kim","year":"2019","unstructured":"Kim JY, Park JH, Kim K, Leem J, Park KK (2019) Melatonin inhibits transforming growth factor-\u03b21-induced epithelial\u2013mesenchymal transition in AML12 hepatocytes. Biology 8(4):84","journal-title":"Biology"},{"issue":"238","key":"3915_CR233","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.116960","volume":"1","author":"K Mortezaee","year":"2019","unstructured":"Mortezaee K, Potes Y, Mirtavoos-Mahyari H, Motevaseli E, Shabeeb D, Musa AE, Najafi M, Farhood B (2019) Boosting immune system against cancer by melatonin: a mechanistic viewpoint. Life Sci 1(238):116960","journal-title":"Life Sci"},{"issue":"4","key":"3915_CR234","first-page":"488","volume":"7","author":"SE Voiculescu","year":"2014","unstructured":"Voiculescu SE, Zygouropoulos N, Zahiu CD, Zagrean AM (2014) Role of melatonin in embryo fetal development. J Med Life 7(4):488","journal-title":"J Med Life"},{"issue":"3","key":"3915_CR235","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.3390\/ijms23031835","volume":"23","author":"I Kvetnoy","year":"2022","unstructured":"Kvetnoy I, Ivanov D, Mironova E, Evsyukova I, Nasyrov R, Kvetnaia T, Polyakova V (2022) Melatonin as the cornerstone of neuroimmunoendocrinology. Int J Mol Sci 23(3):1835","journal-title":"Int J Mol Sci"},{"issue":"16","key":"3915_CR236","doi-asserted-by":"publisher","first-page":"3190","DOI":"10.1111\/bph.14116","volume":"175","author":"N Zisapel","year":"2018","unstructured":"Zisapel N (2018) New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation. Br J Pharmacol 175(16):3190\u20133199","journal-title":"Br J Pharmacol"},{"issue":"2","key":"3915_CR237","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2146\/ajhp130215","volume":"71","author":"JM Damiani","year":"2014","unstructured":"Damiani JM, Sweet BV, Sohoni P (2014) Melatonin: an option for managing sleep disorders in children with autism spectrum disorder. Am J Health Syst Pharm 71(2):95\u2013101","journal-title":"Am J Health Syst Pharm"},{"issue":"5","key":"3915_CR238","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1002\/phar.1920","volume":"37","author":"BM Cuomo","year":"2017","unstructured":"Cuomo BM, Vaz S, Lee EA, Thompson C, Rogerson JM, Falkmer T (2017) Effectiveness of sleep-based interventions for children with autism spectrum disorder: a meta-synthesis. Pharmacotherapy 37(5):555\u201378","journal-title":"Pharmacotherapy"},{"key":"3915_CR239","doi-asserted-by":"publisher","first-page":"1585","DOI":"10.1007\/s11064-014-1347-6","volume":"39","author":"M Adamczyk-Sowa","year":"2014","unstructured":"Adamczyk-Sowa M, Pierzchala K, Sowa P, Mucha S, Sadowska-Bartosz I, Adamczyk J, Hartel M (2014) Melatonin acts as antioxidant and improves sleep in MS patients. Neurochem Res 39:1585\u20131593","journal-title":"Neurochem Res"},{"key":"3915_CR240","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1007\/s00415-009-5196-1","volume":"256","author":"NA Aziz","year":"2009","unstructured":"Aziz NA, Pijl H, Fr\u00f6lich M, Schr\u00f6der-van der Elst JP, van der Bent C, Roelfsema F, Roos RA (2009) Delayed onset of the diurnal melatonin rise in patients with Huntington\u2019s disease. J Neurol. 256:1961\u20135","journal-title":"J Neurol."},{"key":"3915_CR241","doi-asserted-by":"publisher","first-page":"221","DOI":"10.3389\/fpsyt.2019.00221","volume":"10","author":"R Herzog-Krzywoszanska","year":"2019","unstructured":"Herzog-Krzywoszanska R, Krzywoszanski L (2019) Sleep disorders in Huntington\u2019s disease. Front Psychiatry 10:221","journal-title":"Front Psychiatry"},{"issue":"1","key":"3915_CR242","first-page":"33","volume":"31","author":"A Bougea","year":"2016","unstructured":"Bougea A, Spantideas N, Lyras V, Avramidis T, Thomaidis T (2016) Melatonin 4 mg as prophylactic therapy for primary headaches: a pilot study. Funct Neurol 31(1):33","journal-title":"Funct Neurol"},{"issue":"4","key":"3915_CR243","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1002\/mus.27168","volume":"63","author":"EM Bald","year":"2021","unstructured":"Bald EM, Nance CS, Schultz JL (2021) Melatonin may slow disease progression in amyotrophic lateral sclerosis: findings from the pooled resource open-access ALS clinic trials database. Muscle Nerve 63(4):572\u2013576","journal-title":"Muscle Nerve"},{"issue":"4","key":"3915_CR244","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1600-079X.2006.00377.x","volume":"41","author":"JH Weishaupt","year":"2006","unstructured":"Weishaupt JH, Bartels C, P\u00f6lking E, Dietrich J, Rohde G, Poeggeler B, Mertens N, Sperling S et al (2006) Reduced oxidative damage in ALS by high-dose enteral melatonin treatment. J Pineal Res 41(4):313\u2013323","journal-title":"J Pineal Res"},{"issue":"195","key":"3915_CR245","doi-asserted-by":"publisher","first-page":"105878","DOI":"10.1016\/j.clineuro.2020.105878","volume":"1","author":"RD Kakhaki","year":"2020","unstructured":"Kakhaki RD, Ostadmohammadi V, Kouchaki E, Aghadavod E, Bahmani F, Tamtaji OR, Reiter RJ, Mansournia MA et al (2020) Melatonin supplementation and the effects on clinical and metabolic status in Parkinson\u2019s disease: a randomized, double-blind, placebo-controlled trial. Clin Neurol Neurosurg 1(195):105878","journal-title":"Clin Neurol Neurosurg"},{"key":"3915_CR246","doi-asserted-by":"publisher","first-page":"947","DOI":"10.2147\/CIA.S65625","volume":"9","author":"AG Wade","year":"2014","unstructured":"Wade AG, Farmer M, Harari G, Fund N, Laudon M, Nir T, Frydman-Marom A, Zisapel N (2014) Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer\u2019s disease: a 6-month, randomized, placebo-controlled, multicenter trial. Clin Interv Aging 9:947\u2013961. https:\/\/doi.org\/10.2147\/CIA.S65625","journal-title":"Clin Interv Aging"},{"issue":"1","key":"3915_CR247","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1002\/gps.4571","volume":"32","author":"YY Wang","year":"2017","unstructured":"Wang YY, Zheng W, Ng CH, Ungvari GS, Wei W, Xiang YT (2017) Meta-analysis of randomized, double-blind, placebo-controlled trials of melatonin in Alzheimer\u2019s disease. Int J Geriatr Psychiatry 32(1):50\u201357","journal-title":"Int J Geriatr Psychiatry"},{"issue":"10","key":"3915_CR248","doi-asserted-by":"publisher","first-page":"20508","DOI":"10.3390\/ijms141020508","volume":"14","author":"S Tordjman","year":"2013","unstructured":"Tordjman S, Najjar I, Bellissant E, Anderson GM, Barburoth M, Cohen D, Jaafari N, Schischmanoff O et al (2013) Advances in the research of melatonin in autism spectrum disorders: literature review and new perspectives. Int J Mol Sci 14(10):20508\u201320542","journal-title":"Int J Mol Sci"},{"issue":"6","key":"3915_CR249","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1007\/s40265-017-0707-3","volume":"77","author":"JS Emens","year":"2017","unstructured":"Emens JS, Eastman CI (2017) Diagnosis and treatment of non-24-h sleep\u2013wake disorder in the blind. Drugs 77(6):637\u2013650","journal-title":"Drugs"},{"key":"3915_CR250","first-page":"13","volume":"29","author":"T Roth","year":"2015","unstructured":"Roth T, Nir T, Zisapel N (2015) Prolonged release melatonin for improving sleep in totally blind subjects: a pilot placebo-controlled multicenter trial. Nat Sci Sleep 29:13\u201323","journal-title":"Nat Sci Sleep"},{"key":"3915_CR251","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s40265-014-0200-1","volume":"74","author":"S Dhillon","year":"2014","unstructured":"Dhillon S, Clarke M (2014) Tasimelteon: first global approval. Drugs 74:505\u2013511","journal-title":"Drugs"},{"issue":"6","key":"3915_CR252","doi-asserted-by":"publisher","first-page":"895","DOI":"10.1517\/14656566.2012.667076","volume":"13","author":"P Lemoine","year":"2012","unstructured":"Lemoine P, Zisapel N (2012) Prolonged-release formulation of melatonin (Circadin) for the treatment of insomnia. Expert Opin Pharmacother 13(6):895\u2013905","journal-title":"Expert Opin Pharmacother"},{"issue":"6","key":"3915_CR253","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1080\/00207450802328607","volume":"119","author":"V Srinivasan","year":"2009","unstructured":"Srinivasan V, Pandi-Perumal SR, Trahkt I, Spence DW, Poeggeler B, Hardeland R, Cardinali DP (2009) Melatonin and melatonergic drugs on sleep: possible mechanisms of action. Int J Neurosci 119(6):821\u2013846","journal-title":"Int J Neurosci"},{"issue":"6","key":"3915_CR254","doi-asserted-by":"publisher","first-page":"655","DOI":"10.3109\/07420529808993201","volume":"15","author":"A Suhner","year":"1998","unstructured":"Suhner A, Schlagenhauf P, Johnson R, Tschopp A, Steffen R (1998) Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag. Chronobiol Int 15(6):655\u2013666","journal-title":"Chronobiol Int"},{"issue":"1","key":"3915_CR255","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1034\/j.1600-079x.2002.10820.x","volume":"32","author":"DP Cardinali","year":"2002","unstructured":"Cardinali DP, Bortman GP, Liotta G, Lloret SP, Albornoz LE, Cutrera RA, Batista J, Gallo PO (2002) A multifactorial approach employing melatonin to accelerate resynchronization of sleep\u2013wake cycle after a 12 time-zone westerly transmeridian flight in elite soccer athletes. J Pineal Res 32(1):41\u201346","journal-title":"J Pineal Res"},{"issue":"2","key":"3915_CR256","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/j.tmaid.2008.09.004","volume":"7","author":"GM Brown","year":"2009","unstructured":"Brown GM, Pandi-Perumal SR, Trakht I, Cardinali DP (2009) Melatonin and its relevance to jet lag. Travel Med Infect Dis 7(2):69\u201381","journal-title":"Travel Med Infect Dis"},{"issue":"2","key":"3915_CR257","doi-asserted-by":"publisher","first-page":"135","DOI":"10.5152\/eurasianjmed.2015.0267","volume":"48","author":"M Emet","year":"2016","unstructured":"Emet M, Ozcan H, Ozel L, Yayla M, Halici Z, Hacimuftuoglu A (2016) A review of melatonin, its receptors and drugs. Eurasian J Med 48(2):135","journal-title":"Eurasian J Med"},{"key":"3915_CR258","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1007\/s40261-015-0368-5","volume":"36","author":"LP Andersen","year":"2016","unstructured":"Andersen LP, G\u00f6genur I, Rosenberg J, Reiter RJ (2016) The safety of melatonin in humans. Clin Drug Investig 36:169\u2013175","journal-title":"Clin Drug Investig"},{"issue":"42","key":"3915_CR259","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.ctim.2018.11.003","volume":"1","author":"HM Foley","year":"2019","unstructured":"Foley HM, Steel AE (2019) Adverse events associated with oral administration of melatonin: a critical systematic review of clinical evidence. Complement Ther Med 1(42):65\u201381","journal-title":"Complement Ther Med"},{"issue":"9","key":"3915_CR260","doi-asserted-by":"publisher","first-page":"2506","DOI":"10.3390\/molecules26092506","volume":"26","author":"WH Talib","year":"2021","unstructured":"Talib WH, Alsayed AR, Abuawad A, Daoud S, Mahmod AI (2021) Melatonin in cancer treatment: current knowledge and future opportunities. Molecules 26(9):2506","journal-title":"Molecules"},{"issue":"4","key":"3915_CR261","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1177\/1534735411425484","volume":"11","author":"D Seely","year":"2012","unstructured":"Seely D, Wu P, Fritz H, Kennedy DA, Tsui T, Seely AJ, Mills E (2012) Melatonin as adjuvant cancer care with and without chemotherapy: a systematic review and meta-analysis of randomized trials. Integr Cancer Ther 11(4):293\u2013303","journal-title":"Integr Cancer Ther"},{"key":"3915_CR262","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s12551-017-0256-8","volume":"9","author":"M Najafi","year":"2017","unstructured":"Najafi M, Shirazi A, Motevaseli E, Geraily G, Norouzi F, Heidari M, Rezapoor S (2017) The melatonin immunomodulatory actions in radiotherapy. Biophys Rev 9:139\u2013148","journal-title":"Biophys Rev"},{"issue":"4","key":"3915_CR263","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0231379","volume":"15","author":"AC Palmer","year":"2020","unstructured":"Palmer AC, Zortea M, Souza A, Santos V, Biaz\u00fas JV, Torres IL, Fregni F, Caumo W (2020) Clinical impact of melatonin on breast cancer patients undergoing chemotherapy; effects on cognition, sleep and depressive symptoms: a randomized, double-blind, placebo-controlled trial. PLoS ONE 15(4):e0231379","journal-title":"PLoS ONE"},{"issue":"3\u20134","key":"3915_CR264","first-page":"188","volume":"18","author":"MA Ben-David","year":"2016","unstructured":"Ben-David MA, Elkayam R, Gelernter I, Pfeffer RM (2016) Melatonin for prevention of breast radiation dermatitis: a phase II, prospective, double-blind randomized trial. Isr Med Assoc J 18(3\u20134):188\u2013192","journal-title":"Isr Med Assoc J"},{"key":"3915_CR265","doi-asserted-by":"publisher","first-page":"65","DOI":"10.2147\/CPT.S41761","volume":"11","author":"D De Berardis","year":"2015","unstructured":"De Berardis D, Orsolini L, Serroni N, Girinelli G, Iasevoli F, Tomasetti C, Mazza M, Valchera A et al (2015) The role of melatonin in mood disorders. ChronoPhysiol Ther 11:65\u201375","journal-title":"ChronoPhysiol Ther"},{"issue":"2","key":"3915_CR266","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1177\/074873049400900206","volume":"9","author":"RH Van den Hoofdakker","year":"1994","unstructured":"Van den Hoofdakker RH (1994) Chronobiological theories of nonseasonal affective disorders and their implications for treatment. J Biol Rhythms 9(2):157\u2013183","journal-title":"J Biol Rhythms"},{"issue":"10","key":"3915_CR267","doi-asserted-by":"publisher","first-page":"1503","DOI":"10.1517\/13543784.2012.711314","volume":"21","author":"V Srinivasan","year":"2012","unstructured":"Srinivasan V, De Berardis D, Shillcutt SD, Brzezinski A (2012) Role of melatonin in mood disorders and the antidepressant effects of agomelatine. Expert Opin Investig Drugs 21(10):1503\u20131522","journal-title":"Expert Opin Investig Drugs"},{"issue":"11","key":"3915_CR268","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1016\/j.euroneuro.2014.08.008","volume":"24","author":"MV Hansen","year":"2014","unstructured":"Hansen MV, Danielsen AK, Hageman I, Rosenberg J, G\u00f6genur I (2014) The therapeutic or prophylactic effect of exogenous melatonin against depression and depressive symptoms: a systematic review and meta-analysis. Eur Neuropsychopharmacol 24(11):1719\u20131728","journal-title":"Eur Neuropsychopharmacol"},{"issue":"1","key":"3915_CR269","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1111\/j.1440-1819.2011.02288.x","volume":"66","author":"L Livianos","year":"2012","unstructured":"Livianos L, Sierra P, Arques S, Garc\u00eda A, Rojo L (2012) Is melatonin an adjunctive stabilizer? Psychiatry Clin Neurosci 66(1):82\u201383","journal-title":"Psychiatry Clin Neurosci"},{"issue":"3","key":"3915_CR270","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/S0924-977X(02)00175-X","volume":"13","author":"S Lepp\u00e4m\u00e4ki","year":"2003","unstructured":"Lepp\u00e4m\u00e4ki S, Partonen T, Vakkuri O, L\u00f6nnqvist J, Partinen M, Laudon M (2003) Effect of controlled-release melatonin on sleep quality, mood, and quality of life in subjects with seasonal or weather-associated changes in mood and behaviour. Eur Neuropsychopharmacol 13(3):137\u2013145","journal-title":"Eur Neuropsychopharmacol"},{"issue":"3","key":"3915_CR271","doi-asserted-by":"publisher","first-page":"295","DOI":"10.4103\/0973-1075.185039","volume":"22","author":"MS Kurdi","year":"2016","unstructured":"Kurdi MS, Muthukalai SP (2016) The efficacy of oral melatonin in improving sleep in cancer patients with insomnia: a randomized double-blind placebo-controlled study. Indian J Palliat Care 22(3):295","journal-title":"Indian J Palliat Care"},{"key":"3915_CR272","doi-asserted-by":"publisher","unstructured":"Hansen MV, Madsen MT, Andersen LT, Hageman I, Rasmussen LS, Bokmand S, Rosenberg J, G\u00f6genur I (2014) Effect of melatonin on cognitive function and sleep in relation to breast cancer surgery: A randomized, double-blind, placebo-controlled trial. Int J Breast Cancer 2014(416531):9. https:\/\/doi.org\/10.1155\/2014\/416531","DOI":"10.1155\/2014\/416531"},{"issue":"881","key":"3915_CR273","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173282","volume":"15","author":"NF Maroufi","year":"2020","unstructured":"Maroufi NF, Amiri M, Dizaji BF, Vahedian V, Akbarzadeh M, Roshanravan N, Haiaty S, Nouri M et al (2020) Inhibitory effect of melatonin on hypoxia-induced vasculogenic mimicry via suppressing epithelial-mesenchymal transition (EMT) in breast cancer stem cells. Eur J Pharmacol 15(881):173282","journal-title":"Eur J Pharmacol"},{"issue":"7","key":"3915_CR274","doi-asserted-by":"publisher","first-page":"1043","DOI":"10.1080\/09291016.2021.1899485","volume":"53","author":"WJ Hrushesky","year":"2022","unstructured":"Hrushesky WJ, Lis CG, Levin RD, Grutsch JF, Birdsall T, Wood PA, Huff DF, Reynolds JL et al (2022) Daily evening melatonin prolongs survival among patients with advanced non-small-cell lung cancer. Biol Rhythm Res 53(7):1043\u20131057","journal-title":"Biol Rhythm Res"},{"issue":"12","key":"3915_CR275","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1089\/acm.2017.0081","volume":"23","author":"K Onseng","year":"2017","unstructured":"Onseng K, Johns NP, Khuayjarernpanishk T, Subongkot S, Priprem A, Hurst C, Johns J (2017) Beneficial effects of adjuvant melatonin in minimizing oral mucositis complications in head and neck cancer patients receiving concurrent chemoradiation. J Altern Complement Med 23(12):957\u2013963","journal-title":"J Altern Complement Med"},{"issue":"3","key":"3915_CR276","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/odi.13265","volume":"26","author":"HH Elsabagh","year":"2020","unstructured":"Elsabagh HH, Moussa E, Mahmoud SA, Elsaka RO, Abdelrahman H (2020) Efficacy of melatonin in prevention of radiation-induced oral mucositis: a randomized clinical trial. Oral Dis 26(3):566\u2013572","journal-title":"Oral Dis"},{"issue":"1","key":"3915_CR277","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s10557-020-07052-3","volume":"36","author":"MH Pourhanifeh","year":"2022","unstructured":"Pourhanifeh MH, Dehdashtian E, Hosseinzadeh A, Sezavar SH, Mehrzadi S (2022) Clinical application of melatonin in the treatment of cardiovascular diseases: current evidence and new insights into the cardioprotective and cardiotherapeutic properties. Cardiovasc Drugs Ther 36(1):131\u2013155","journal-title":"Cardiovasc Drugs Ther"},{"key":"3915_CR278","doi-asserted-by":"publisher","first-page":"51","DOI":"10.2147\/CCID.S153905","volume":"24","author":"M Milani","year":"2018","unstructured":"Milani M, Sparavigna A (2018) Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial. Clin Cosmet Investig Dermatol 24:51\u201357","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"2","key":"3915_CR279","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1177\/1933719117711262","volume":"25","author":"V Tagliaferri","year":"2018","unstructured":"Tagliaferri V, Romualdi D, Scarinci E, Cicco SD, Florio CD, Immediata V, Tropea A, Santarsiero CM et al (2018) Melatonin treatment may be able to restore menstrual cyclicity in women with PCOS: a pilot study. Reprod Sci 25(2):269\u2013275","journal-title":"Reprod Sci"},{"issue":"5","key":"3915_CR280","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/ijmm.2021.4915","volume":"47","author":"X Lu","year":"2021","unstructured":"Lu X, Yu S, Chen G, Zheng W, Peng J, Huang X, Chen L (2021) Insight into the roles of melatonin in bone tissue and bone-related diseases. Int J Mol Med 47(5):1\u20139","journal-title":"Int J Mol Med"},{"issue":"1","key":"3915_CR281","doi-asserted-by":"publisher","first-page":"e122","DOI":"10.4317\/medoral.20904","volume":"21","author":"H Shino","year":"2016","unstructured":"Shino H, Hasuike A, Arai Y, Honda M, Isokawa K, Sato S (2016) Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces. Medicina Oral Patologia Oral y Cirugia Bucal 21(1):e122","journal-title":"Medicina Oral Patologia Oral y Cirugia Bucal"},{"issue":"6","key":"3915_CR282","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1080\/13697137.2016.1226608","volume":"19","author":"A Pines","year":"2016","unstructured":"Pines A (2016) Circadian rhythm and menopause. Climacteric 19(6):551\u2013552","journal-title":"Climacteric"},{"key":"3915_CR283","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s13287-018-0892-3","volume":"9","author":"B Gao","year":"2018","unstructured":"Gao B, Gao W, Wu Z, Zhou T, Qiu X, Wang X, Lian C, Peng Y et al (2018) Melatonin rescued interleukin 1\u03b2-impaired chondrogenesis of human mesenchymal stem cells. Stem Cell Res Ther 9:1\u20132","journal-title":"Stem Cell Res Ther"},{"issue":"1","key":"3915_CR284","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/adj.12294","volume":"61","author":"NA Ghallab","year":"2016","unstructured":"Ghallab NA, Hamdy E, Shaker OG (2016) Malondialdehyde, superoxide dismutase and melatonin levels in gingival crevicular fluid of aggressive and chronic periodontitis patients. Aust Dent J 61(1):53\u201361","journal-title":"Aust Dent J"},{"issue":"10","key":"3915_CR285","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3389\/fendo.2019.00273","volume":"14","author":"M Jamilian","year":"2019","unstructured":"Jamilian M, Foroozanfard F, Mirhosseini N, Kavossian E, Aghadavod E, Bahmani F, Ostadmohammadi V, Kia M et al (2019) Effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome. Front Endocrinol 14(10):273","journal-title":"Front Endocrinol"},{"issue":"1","key":"3915_CR286","doi-asserted-by":"publisher","first-page":"218","DOI":"10.3390\/ijms23010218","volume":"23","author":"Q Guan","year":"2021","unstructured":"Guan Q, Wang Z, Cao J, Dong Y, Chen Y (2021) Mechanisms of melatonin in obesity: a review. Int J Mol Sci 23(1):218","journal-title":"Int J Mol Sci"},{"key":"3915_CR287","first-page":"2020","volume":"28","author":"L Xiao","year":"2020","unstructured":"Xiao L, Lin J, Chen R, Huang Y, Liu Y, Bai J, Ge G, Shi X et al (2020) Sustained release of melatonin from GelMA liposomes reduced osteoblast apoptosis and improved implant osseointegration in osteoporosis. Oxid Med Cell Longev 28:2020","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"3915_CR288","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12548","volume":"66","author":"T Li","year":"2019","unstructured":"Li T, Jiang S, Lu C, Yang W, Yang Z, Hu W, Xin Z, Yang Y (2019) Melatonin: another avenue for treating osteoporosis? J Pineal Res 66(2):e12548","journal-title":"J Pineal Res"},{"issue":"12","key":"3915_CR289","first-page":"1298","volume":"81","author":"G Mistraletti","year":"2015","unstructured":"Mistraletti G, Umbrello M, Sabbatini G, Miori S, Taverna M, Cerri B, Mantovani ES, Formenti P et al (2015) Melatonin reduces the need for sedation in ICU patients: a randomized controlled trial. Minerva Anestesiol 81(12):1298\u20131310","journal-title":"Minerva Anestesiol"},{"issue":"1","key":"3915_CR290","doi-asserted-by":"publisher","first-page":"100","DOI":"10.3390\/ijms23010100","volume":"23","author":"K Oliveira-Abreu","year":"2021","unstructured":"Oliveira-Abreu K, Cipolla-Neto J, Leal-Cardoso JH (2021) Effects of melatonin on diabetic neuropathy and retinopathy. Int J Mol Sci 23(1):100","journal-title":"Int J Mol Sci"},{"key":"3915_CR291","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s00228-021-03170-5","volume":"77","author":"M Shokri","year":"2021","unstructured":"Shokri M, Sajedi F, Mohammadi Y, Mehrpooya M (2021) Adjuvant use of melatonin for relieving symptoms of painful diabetic neuropathy: results of a randomized, double-blinded, controlled trial. Eur J Clin Pharmacol 77:1649\u20131663","journal-title":"Eur J Clin Pharmacol"},{"issue":"59","key":"3915_CR292","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1590\/2359-3997000000098","volume":"28","author":"S Sharma","year":"2015","unstructured":"Sharma S, Singh H, Ahmad N, Mishra P, Tiwari A (2015) The role of melatonin in diabetes: therapeutic implications. Arch Endocrinol Metab 28(59):391\u2013399","journal-title":"Arch Endocrinol Metab"},{"issue":"69","key":"3915_CR293","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.sleep.2020.01.019","volume":"1","author":"K Lewandowska","year":"2020","unstructured":"Lewandowska K, Ma\u0142kiewicz MA, Siemi\u0144ski M, Cuba\u0142a WJ, Winklewski PJ, M\u0119drzycka-D\u0105browska WA (2020) The role of melatonin and melatonin receptor agonist in the prevention of sleep disturbances and delirium in intensive care unit \u2013 a clinical review. Sleep Med 1(69):127\u2013134","journal-title":"Sleep Med"},{"issue":"5","key":"3915_CR294","doi-asserted-by":"publisher","first-page":"2102","DOI":"10.1002\/jmv.27595","volume":"94","author":"SH Lan","year":"2022","unstructured":"Lan SH, Lee HZ, Chao CM, Chang SP, Lu LC, Lai CC (2022) Efficacy of melatonin in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials. J Med Virol 94(5):2102\u20132107","journal-title":"J Med Virol"},{"key":"3915_CR295","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1007\/s40263-019-00680-w","volume":"33","author":"FM Besag","year":"2019","unstructured":"Besag FM, Vasey MJ, Lao KS, Wong IC (2019) Adverse events associated with melatonin for the treatment of primary or secondary sleep disorders: a systematic review. CNS Drugs 33:1167\u20131186","journal-title":"CNS Drugs"},{"issue":"11","key":"3915_CR296","doi-asserted-by":"publisher","first-page":"1088","DOI":"10.3390\/antiox9111088","volume":"9","author":"N Ferlazzo","year":"2020","unstructured":"Ferlazzo N, Andolina G, Cannata A, Costanzo MG, Rizzo V, Curr\u00f2 M, Ientile R, Caccamo D (2020) Is melatonin the cornucopia of the 21st century? Antioxidants 9(11):1088","journal-title":"Antioxidants"},{"issue":"4","key":"3915_CR297","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1038\/ncpneuro0467","volume":"3","author":"SR Pandi-Perumal","year":"2007","unstructured":"Pandi-Perumal SR, Srinivasan V, Poeggeler B, Hardeland R, Cardinali DP (2007) Drug insight: the use of melatonergic agonists for the treatment of insomnia\u2014focus on ramelteon. Nat Clin Pract Neurol 3(4):221\u2013228","journal-title":"Nat Clin Pract Neurol"},{"key":"3915_CR298","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.2165\/00023210-200519120-00007","volume":"19","author":"A McGechan","year":"2005","unstructured":"McGechan A, Wellington K (2005) Ramelteon. CNS Drugs 19:1057\u20131065","journal-title":"CNS Drugs"},{"issue":"8","key":"3915_CR299","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1038\/nrd3140","volume":"9","author":"C De Bodinat","year":"2010","unstructured":"De Bodinat C, Guardiola-Lemaitre B, Moca\u00ebr E, Renard P, Mu\u00f1oz C, Millan MJ (2010) Agomelatine, the first melatonergic antidepressant: discovery, characterization and development. Nat Rev Drug Discovery 9(8):628\u2013642","journal-title":"Nat Rev Drug Discovery"},{"issue":"3","key":"3915_CR300","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1124\/jpet.103.051797","volume":"306","author":"MJ Millan","year":"2003","unstructured":"Millan MJ, Gobert A, Lejeune F, Dekeyne A, Newman-Tancredi A, Pasteau V, Rivet JM, Cussac D (2003) The novel melatonin agonist agomelatine (S20098) is an antagonist at 5-hydroxytryptamine2C receptors, blockade of which enhances the activity of frontocortical dopaminergic and adrenergic pathways. J Pharmacol Exp Ther 306(3):954\u2013964","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"3915_CR301","first-page":"194","volume":"3","author":"R Hardeland","year":"2012","unstructured":"Hardeland R (2012) Melatonin in aging and disease\u2014multiple consequences of reduced secretion, options and limits of treatment. Aging Dis 3(2):194","journal-title":"Aging Dis"},{"issue":"15","key":"3915_CR302","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1016\/j.lfs.2004.03.023","volume":"75","author":"JJ Mulchahey","year":"2004","unstructured":"Mulchahey JJ, Goldwater DR, Zemlan FP (2004) A single blind, placebo controlled, across groups dose escalation study of the safety, tolerability, pharmacokinetics and pharmacodynamics of the melatonin analog \u03b2-methyl-6-chloromelatonin. Life Sci 75(15):1843\u20131856","journal-title":"Life Sci"},{"key":"3915_CR303","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1475-2891-13-106","volume":"13","author":"RB Costello","year":"2014","unstructured":"Costello RB, Lentino CV, Boyd CC, O\u2019Connell ML, Crawford CC, Sprengel ML, Deuster PA (2014) The effectiveness of melatonin for promoting healthy sleep: a rapid evidence assessment of the literature. Nutr J 13:1\u20137","journal-title":"Nutr J"},{"issue":"7","key":"3915_CR304","doi-asserted-by":"publisher","first-page":"681","DOI":"10.3390\/cells8070681","volume":"8","author":"B Salehi","year":"2019","unstructured":"Salehi B, Sharopov F, Fokou PV, Kobylinska A, Jonge LD, Tadio K, Sharifi-Rad J, Posmyk MM et al (2019) Melatonin in medicinal and food plants: occurrence, bioavailability, and health potential for humans. Cells 8(7):681","journal-title":"Cells"},{"issue":"170","key":"3915_CR305","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.foodchem.2014.08.071","volume":"1","author":"Y Aguilera","year":"2015","unstructured":"Aguilera Y, Herrera T, Ben\u00edtez V, Arribas SM, de Pablo AL, Esteban RM, Mart\u00edn-Cabrejas MA (2015) Estimation of scavenging capacity of melatonin and other antioxidants: contribution and evaluation in germinated seeds. Food Chem 1(170):203\u2013211","journal-title":"Food Chem"},{"issue":"1","key":"3915_CR306","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1111\/acps.13201","volume":"142","author":"MT Samara","year":"2020","unstructured":"Samara MT, Huhn M, Chiocchia V, Schneider-Thoma J, Wiegand M, Salanti G, Leucht S (2020) Efficacy, acceptability, and tolerability of all available treatments for insomnia in the elderly: a systematic review and network meta-analysis. Acta Psychiatr Scand 142(1):6\u201317","journal-title":"Acta Psychiatr Scand"},{"issue":"3","key":"3915_CR307","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1089\/jmf.2009.0096","volume":"13","author":"WR Pigeon","year":"2010","unstructured":"Pigeon WR, Carr M, Gorman C, Perlis ML (2010) Effects of a tart cherry juice beverage on the sleep of older adults with insomnia: a pilot study. J Med Food 13(3):579\u2013583","journal-title":"J Med Food"},{"issue":"19","key":"3915_CR308","doi-asserted-by":"publisher","first-page":"6087","DOI":"10.3390\/molecules26196087","volume":"26","author":"W Kukula-Koch","year":"2021","unstructured":"Kukula-Koch W, Szwajgier D, Gawe\u0142-B\u0119ben K, Strz\u0119pek-Gom\u00f3\u0142ka M, G\u0142owniak K, Meissner HO (2021) Is Phytomelatonin complex better than synthetic melatonin? The assessment of the antiradical and anti-inflammatory properties. Molecules 26(19):6087","journal-title":"Molecules"},{"issue":"10","key":"3915_CR309","doi-asserted-by":"publisher","first-page":"4727","DOI":"10.1210\/jcem.86.10.7901","volume":"86","author":"IV Zhdanova","year":"2001","unstructured":"Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU (2001) Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab 86(10):4727\u20134730","journal-title":"J Clin Endocrinol Metab"},{"key":"3915_CR310","unstructured":"(2023) Drugs and Lactation Database (LactMed\u00ae) [Internet]. National Institute of Child Health and Human Development; Bethesda (MD): Melatonin"},{"issue":"3","key":"3915_CR311","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1034\/j.1600-079X.2001.310305.x","volume":"31","author":"P L\u00fcdemann","year":"2001","unstructured":"L\u00fcdemann P, Zwernemann S, Lerchl A (2001) Clearance of melatonin and 6-sulfatoxymelatonin by hemodialysis in patients with end-stage renal disease. J Pineal Res 31(3):222\u2013227","journal-title":"J Pineal Res"},{"key":"3915_CR312","unstructured":"(2020)LiverTox: clinical and research information on drug-induced liver injury [Internet]. National Institute of Diabetes and Digestive and Kidney Diseases; Bethesda (MD)"},{"key":"3915_CR313","unstructured":"Therapeutic Research. Melatonin. Available online: https:\/\/naturalmedicines.therapeuticresearch.com\/. Accessed on 28\u201311\u20132023"},{"issue":"3\u20134","key":"3915_CR314","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1159\/000510252","volume":"106","author":"D Zetner","year":"2021","unstructured":"Zetner D, Andersen LP, Alder R, Jessen ML, Tolstrup A, Rosenberg J (2021) Pharmacokinetics and safety of intravenous, intravesical, rectal, transdermal, and vaginal melatonin in healthy female volunteers: a cross-over study. Pharmacology 106(3\u20134):169\u2013176","journal-title":"Pharmacology"},{"issue":"3","key":"3915_CR315","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3892\/etm.2022.11142","volume":"23","author":"L Anghel","year":"2022","unstructured":"Anghel L, Baroiu L, Popazu CR, P\u0103tra\u0219 D, Fotea S, Nechifor A, Ciubara A, Nechita L et al (2022) Benefits and adverse events of melatonin use in the elderly. Exp Ther Med 23(3):1\u20138","journal-title":"Exp Ther Med"},{"issue":"1","key":"3915_CR316","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1177\/07487304211064218","volume":"37","author":"DB Boivin","year":"2022","unstructured":"Boivin DB, Boudreau P, Kosmadopoulos A (2022) Disturbance of the circadian system in shift work and its health impact. J Biol Rhythms 37(1):3\u201328","journal-title":"J Biol Rhythms"},{"issue":"5","key":"3915_CR317","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/j.patbio.2014.08.001","volume":"62","author":"DB Boivin","year":"2014","unstructured":"Boivin DB, Boudreau P (2014) Impacts of shift work on sleep and circadian rhythms. Pathol Biol (Paris) 62(5):292\u2013301","journal-title":"Pathol Biol (Paris)"},{"issue":"3","key":"3915_CR318","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.sxmr.2017.11.009","volume":"6","author":"N Deng","year":"2018","unstructured":"Deng N, Kohn TP, Lipshultz LI, Pastuszak AW (2018) The relationship between shift work and men\u2019s health. Sex Med Rev 6(3):446\u2013456","journal-title":"Sex Med Rev"},{"issue":"12","key":"3915_CR319","doi-asserted-by":"publisher","first-page":"638252","DOI":"10.3389\/fpsyg.2021.638252","volume":"23","author":"S Pallesen","year":"2021","unstructured":"Pallesen S, Bjorvatn B, Waage S, Harris A, Sagoe D (2021) Prevalence of shift work disorder: a systematic review and meta-analysis. Front Psychol 23(12):638252","journal-title":"Front Psychol"},{"issue":"2","key":"3915_CR320","doi-asserted-by":"publisher","first-page":"203","DOI":"10.3109\/07420528.2011.647177","volume":"29","author":"M Dumont","year":"2012","unstructured":"Dumont M, Lanct\u00f4t V, Cadieux-Viau R, Paquet J (2012) Melatonin production and light exposure of rotating night workers. Chronobiol Int 29(2):203\u2013210","journal-title":"Chronobiol Int"},{"issue":"5","key":"3915_CR321","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1158\/1055-9965.EPI-15-1178","volume":"25","author":"M Leung","year":"2016","unstructured":"Leung M, Tranmer J, Hung E, Korsiak J, Day AG, Aronson KJ (2016) Shift work, chronotype, and melatonin patterns among female hospital employees on day and night shifts. Cancer Epidemiol Biomark Prev 25(5):830\u2013838","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"6","key":"3915_CR322","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000303","volume":"17","author":"L Kervezee","year":"2019","unstructured":"Kervezee L, Cermakian N, Boivin DB (2019) Individual metabolomic signatures of circadian misalignment during simulated night shifts in humans. PLoS Biol 17(6):e3000303","journal-title":"PLoS Biol"},{"key":"3915_CR323","doi-asserted-by":"publisher","first-page":"295","DOI":"10.5271\/sjweh.3414","volume":"1","author":"M Bracci","year":"2014","unstructured":"Bracci M, Manzella N, Copertaro A, Staffolani S, Strafella E, Barbaresi M, Copertaro B, Rapisarda V et al (2014) Rotating-shift nurses after a day off: peripheral clock gene expression, urinary melatonin, and serum 17-\u03b2-estradiol levels. Scand J Work Environ Health 1:295\u2013304","journal-title":"Scand J Work Environ Health"},{"issue":"6","key":"3915_CR324","doi-asserted-by":"publisher","first-page":"6789","DOI":"10.1096\/fj.201801889R","volume":"33","author":"A Koshy","year":"2019","unstructured":"Koshy A, Cuesta M, Boudreau P, Cermakian N, Boivin DB (2019) Disruption of central and peripheral circadian clocks in police officers working at night. FASEB J 33(6):6789\u20136800","journal-title":"FASEB J"},{"issue":"1","key":"3915_CR325","doi-asserted-by":"publisher","first-page":"41","DOI":"10.5271\/sjweh.3991","volume":"48","author":"BN Harding","year":"2022","unstructured":"Harding BN, Casta\u00f1o-Vinyals G, Palomar-Cros A, Papantoniou K, Espinosa A, Skene DJ, Middleton B, Gomez-Gomez A et al (2022) Changes in melatonin and sex steroid hormone production among men as a result of rotating night shift work \u2013 the HORMONIT study. Scand J Work Environ Health 48(1):41","journal-title":"Scand J Work Environ Health"},{"issue":"1","key":"3915_CR326","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1080\/07420528.2018.1515771","volume":"36","author":"\u00c9L Reinhardt","year":"2019","unstructured":"Reinhardt \u00c9L, Fernandes PA, Markus RP, Fischer FM (2019) Night work effects on salivary cytokines TNF, IL-1\u03b2 and IL-6. Chronobiol Int 36(1):11\u201326","journal-title":"Chronobiol Int"},{"issue":"3","key":"3915_CR327","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1159\/000363426","volume":"9","author":"M Basler","year":"2014","unstructured":"Basler M, Jetter A, Fink D, Seifert B, Kullak-Ublick GA, Trojan A (2014) Urinary excretion of melatonin and association with breast cancer: meta-analysis and review of the literature. Breast Care 9(3):182\u2013187","journal-title":"Breast Care"},{"issue":"3","key":"3915_CR328","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1093\/humrep\/dey390","volume":"34","author":"D Stock","year":"2019","unstructured":"Stock D, Knight JA, Raboud J, Cotterchio M, Strohmaier S, Willett W, Eliassen AH, Rosner B et al (2019) Rotating night shift work and menopausal age. Hum Reprod 34(3):539\u2013548","journal-title":"Hum Reprod"},{"issue":"12","key":"3915_CR329","doi-asserted-by":"publisher","first-page":"680","DOI":"10.3390\/medicina56120680","volume":"56","author":"J Fagundo-Rivera","year":"2020","unstructured":"Fagundo-Rivera J, G\u00f3mez-Salgado J, Garc\u00eda-Iglesias JJ, G\u00f3mez-Salgado C, Camacho-Mart\u00edn S, Ruiz-Frutos C (2020) Relationship between night shifts and risk of breast cancer among nurses: a systematic review. Medicina 56(12):680","journal-title":"Medicina"},{"issue":"9","key":"3915_CR330","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.msard.2016.06.010","volume":"1","author":"S Gustavsen","year":"2016","unstructured":"Gustavsen S, S\u00f8ndergaard HB, Oturai DB, Laursen B, Laursen JH, Magyari M, Ullum H, Larsen MH et al (2016) Shift work at young age is associated with increased risk of multiple sclerosis in a Danish population. Multiple Sclerosis and Related Disorders 1(9):104\u2013109","journal-title":"Multiple Sclerosis and Related Disorders"},{"issue":"4","key":"3915_CR331","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1177\/1099800417714069","volume":"19","author":"CM Hunter","year":"2017","unstructured":"Hunter CM, Figueiro MG (2017) Measuring light at night and melatonin levels in shift workers: a review of the literature. Biol Res Nurs 19(4):365\u2013374","journal-title":"Biol Res Nurs"},{"issue":"1","key":"3915_CR332","doi-asserted-by":"publisher","first-page":"11976","DOI":"10.1038\/s41598-021-89321-1","volume":"11","author":"C Lam","year":"2021","unstructured":"Lam C, Chung MH (2021) Dose\u2013response effects of light therapy on sleepiness and circadian phase shift in shift workers: a meta-analysis and moderator analysis. Sci Rep 11(1):11976","journal-title":"Sci Rep"},{"issue":"1","key":"3915_CR333","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3233\/WOR-162376","volume":"55","author":"K Sadeghniiat-Haghighi","year":"2016","unstructured":"Sadeghniiat-Haghighi K, Bahrami H, Aminian O, Meysami A, Khajeh-Mehrizi A (2016) Melatonin therapy in shift workers with difficulty falling asleep: a randomized, double-blind, placebo-controlled crossover field study. Work 55(1):225\u2013230","journal-title":"Work"},{"key":"3915_CR334","doi-asserted-by":"publisher","first-page":"S11","DOI":"10.5694\/mja13.10561","volume":"199","author":"SM Rajaratnam","year":"2013","unstructured":"Rajaratnam SM, Howard ME, Grunstein RR (2013) Sleep loss and circadian disruption in shift work: health burden and management. Med J Aust 199:S11\u2013S15","journal-title":"Med J Aust"},{"issue":"2","key":"3915_CR335","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/07420528.2017.1394321","volume":"35","author":"S Nagashima","year":"2018","unstructured":"Nagashima S, Osawa M, Matsuyama H, Ohoka W, Ahn A, Wakamura T (2018) Bright-light exposure during daytime sleeping affects nocturnal melatonin secretion after simulated night work. Chronobiol Int 35(2):229\u2013239","journal-title":"Chronobiol Int"},{"issue":"9","key":"3915_CR336","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1001\/jama.2014.18422","volume":"313","author":"J Liira","year":"2015","unstructured":"Liira J, Verbeek J, Ruotsalainen J (2015) Pharmacological interventions for sleepiness and sleep disturbances caused by shift work. JAMA 313(9):961\u2013962","journal-title":"JAMA"},{"issue":"11","key":"3915_CR337","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1136\/oemed-2022-108251","volume":"79","author":"I Forthun","year":"2022","unstructured":"Forthun I, Waage S, Pallesen S, Moen BE, Bjorvatn B (2022) A shift to something better? A longitudinal study of work schedule and prescribed sleep medication use in nurses. Occup Environ Med 79(11):752\u2013757","journal-title":"Occup Environ Med"},{"issue":"11","key":"3915_CR338","doi-asserted-by":"publisher","first-page":"872","DOI":"10.3389\/fpsyt.2020.00872","volume":"27","author":"BM Thottakam","year":"2020","unstructured":"Thottakam BM, Webster NR, Allen L, Columb MO, Galley HF (2020) Melatonin is a feasible, safe, and acceptable intervention in doctors and nurses working nightshifts: the MIDNIGHT trial. Front Psych 27(11):872","journal-title":"Front Psych"},{"issue":"2","key":"3915_CR339","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.shaw.2017.07.007","volume":"9","author":"R Kazemi","year":"2018","unstructured":"Kazemi R, Motamedzade M, Golmohammadi R, Mokarami H, Hemmatjo R, Heidarimoghadam R (2018) Field study of effects of night shifts on cognitive performance, salivary melatonin, and sleep. Saf Health Work 9(2):203\u2013209","journal-title":"Saf Health Work"},{"issue":"7","key":"3915_CR340","doi-asserted-by":"publisher","first-page":"1177","DOI":"10.1158\/1055-9965.EPI-18-1018","volume":"28","author":"P Razavi","year":"2019","unstructured":"Razavi P, Devore EE, Bajaj A, Lockley SW, Figueiro MG, Ricchiuti V, Gauderman WJ, Hankinson SE et al (2019) Shift work, chronotype, and melatonin rhythm in nurses. Cancer Epidemiol Biomark Prev 28(7):1177\u20131186","journal-title":"Cancer Epidemiol Biomark Prev"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03915-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-03915-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03915-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T10:15:11Z","timestamp":1721038511000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-03915-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,11]]},"references-count":340,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["3915"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-03915-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,11]]},"assertion":[{"value":"9 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 December 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This is a review article. Appropriate approval\/ethical approval is already taken. Consent part from the subject is not applicable for this review article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"All the authors agreed to submit the manuscript in the journal. The same has approved by the parent institute.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}