{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T13:27:41Z","timestamp":1784122061576,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T00:00:00Z","timestamp":1707523200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202436"],"award-info":[{"award-number":["82202436"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Medical Research Project of Jiangsu Provincial Health Commission","award":["ZDB2020004"],"award-info":[{"award-number":["ZDB2020004"]}]},{"name":"Research project of Nantong Health Commission","award":["MA2021016"],"award-info":[{"award-number":["MA2021016"]}]},{"name":"Research project of Nantong Health Commission","award":["MS2022016"],"award-info":[{"award-number":["MS2022016"]}]},{"DOI":"10.13039\/501100018557","name":"Nantong Science and Technology Project","doi-asserted-by":"crossref","award":["MS22022004"],"award-info":[{"award-number":["MS22022004"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100018557","name":"Nantong Science and Technology Project","doi-asserted-by":"crossref","award":["JC22022067"],"award-info":[{"award-number":["JC22022067"]}],"id":[{"id":"10.13039\/501100018557","id-type":"DOI","asserted-by":"crossref"}]},{"name":"High-level Science and Technology Project Nurturing Fund of Nantong First People's Hospital","award":["YPYJJZD009"],"award-info":[{"award-number":["YPYJJZD009"]}]},{"name":"Science and Technology Projects in Jiangsu Province","award":["BE2023742"],"award-info":[{"award-number":["BE2023742"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s12035-024-03956-5","type":"journal-article","created":{"date-parts":[[2024,2,10]],"date-time":"2024-02-10T03:02:22Z","timestamp":1707534142000},"page":"6675-6687","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Contribution of ApoB-100\/SORT1-Mediated Immune Microenvironment in Regulating Oxidative Stress, Inflammation, and Ferroptosis After Spinal Cord Injury"],"prefix":"10.1007","volume":"61","author":[{"given":"Chunshuai","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaochen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guofeng","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanhua","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7064-5874","authenticated-orcid":false,"given":"Zhiming","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,10]]},"reference":[{"key":"3956_CR1","doi-asserted-by":"crossref","unstructured":"Michinaga S, Koyama Y (2021) Pathophysiological responses and roles of astrocytes in traumatic brain injury. Int J Mol Sci 22(12):6418","DOI":"10.3390\/ijms22126418"},{"issue":"8","key":"3956_CR2","doi-asserted-by":"publisher","first-page":"e13092","DOI":"10.1111\/cpr.13092","volume":"54","author":"L Xu","year":"2021","unstructured":"Xu L et al (2021) T-cell infiltration, contribution and regulation in the central nervous system post-traumatic injury. Cell Prolif 54(8):e13092","journal-title":"Cell Prolif"},{"issue":"2","key":"3956_CR3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10143-018-1008-3","volume":"43","author":"SA Quadri","year":"2020","unstructured":"Quadri SA et al (2020) Recent update on basic mechanisms of spinal cord injury. Neurosurg Rev 43(2):425\u2013441","journal-title":"Neurosurg Rev"},{"key":"3956_CR4","doi-asserted-by":"publisher","first-page":"248","DOI":"10.3389\/fncel.2019.00248","volume":"13","author":"H Katoh","year":"2019","unstructured":"Katoh H, Yokota K, Fehlings MG (2019) Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds. Front Cell Neurosci 13:248","journal-title":"Front Cell Neurosci"},{"issue":"4","key":"3956_CR5","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1159\/000524867","volume":"56","author":"A Golestani","year":"2022","unstructured":"Golestani A et al (2022) Epidemiology of traumatic spinal cord injury in developing countries from 2009 to 2020: a systematic review and meta-analysis. Neuroepidemiology 56(4):219\u2013239","journal-title":"Neuroepidemiology"},{"issue":"6","key":"3956_CR6","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1038\/s41591-019-0475-6","volume":"25","author":"G Courtine","year":"2019","unstructured":"Courtine G, Sofroniew MV (2019) Spinal cord repair: advances in biology and technology. Nat Med 25(6):898\u2013908","journal-title":"Nat Med"},{"issue":"2","key":"3956_CR7","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1152\/physrev.00017.2017","volume":"98","author":"AP Tran","year":"2018","unstructured":"Tran AP, Warren PM, Silver J (2018) The biology of regeneration failure and success after spinal cord injury. Physiol Rev 98(2):881\u2013917","journal-title":"Physiol Rev"},{"issue":"7","key":"3956_CR8","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.bbadis.2012.12.001","volume":"1832","author":"M Lech","year":"2013","unstructured":"Lech M, Anders HJ (2013) Macrophages and fibrosis: how resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair. Biochim Biophys Acta 1832(7):989\u2013997","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"3956_CR9","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1038\/nrn3053","volume":"12","author":"S David","year":"2011","unstructured":"David S, Kroner A (2011) Repertoire of microglial and macrophage responses after spinal cord injury. Nat Rev Neurosci 12(7):388\u2013399","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"3956_CR10","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.atherosclerosis.2013.10.005","volume":"231","author":"LR Paim","year":"2013","unstructured":"Paim LR et al (2013) Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects. Atherosclerosis 231(2):341\u2013345","journal-title":"Atherosclerosis"},{"issue":"6","key":"3956_CR11","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1089\/neu.2018.5880","volume":"36","author":"LR Paim","year":"2019","unstructured":"Paim LR et al (2019) Circulating microRNAs, vascular risk, and physical activity in spinal cord-injured subjects. J Neurotrauma 36(6):845\u2013852","journal-title":"J Neurotrauma"},{"issue":"1","key":"3956_CR12","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1248\/bpb.b15-00716","volume":"39","author":"SY Morita","year":"2016","unstructured":"Morita SY (2016) Metabolism and modification of apolipoprotein B-containing lipoproteins involved in dyslipidemia and atherosclerosis. Biol Pharm Bull 39(1):1\u201324","journal-title":"Biol Pharm Bull"},{"issue":"3","key":"3956_CR13","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.cmet.2010.08.006","volume":"12","author":"M Kjolby","year":"2010","unstructured":"Kjolby M et al (2010) Sort1, encoded by the cardiovascular risk locus 1p13.3, is a regulator of hepatic lipoprotein export. Cell Metab 12(3):213\u201323","journal-title":"Cell Metab"},{"key":"3956_CR14","doi-asserted-by":"publisher","first-page":"547047","DOI":"10.3389\/fvets.2020.547047","volume":"7","author":"B Zhang","year":"2020","unstructured":"Zhang B et al (2020) Lipid accumulation and injury in primary calf hepatocytes challenged with different long-chain fatty acids. Front Vet Sci 7:547047","journal-title":"Front Vet Sci"},{"key":"3956_CR15","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.bbrc.2021.05.011","volume":"561","author":"G Su","year":"2021","unstructured":"Su G et al (2021) SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Beta and IL-18. Biochem Biophys Res Commun 561:33\u201339","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"3956_CR16","doi-asserted-by":"publisher","first-page":"7661","DOI":"10.1038\/s41598-017-08052-4","volume":"7","author":"Z He","year":"2017","unstructured":"He Z et al (2017) Inhibition of endoplasmic reticulum stress preserves the integrity of blood-spinal cord barrier in diabetic rats subjected to spinal cord injury. Sci Rep 7(1):7661","journal-title":"Sci Rep"},{"key":"3956_CR17","doi-asserted-by":"crossref","unstructured":"Anjum A et al (2020) Spinal cord injury: pathophysiology, multimolecular interactions, and underlying recovery mechanisms. Int J Mol Sci 21(20):7533","DOI":"10.3390\/ijms21207533"},{"issue":"7","key":"3956_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1016\/j.tem.2008.07.002","volume":"19","author":"JL Brodsky","year":"2008","unstructured":"Brodsky JL, Fisher EA (2008) The many intersecting pathways underlying apolipoprotein B secretion and degradation. Trends Endocrinol Metab 19(7):254\u2013259","journal-title":"Trends Endocrinol Metab"},{"key":"3956_CR19","doi-asserted-by":"publisher","first-page":"662967","DOI":"10.3389\/fninf.2021.662967","volume":"15","author":"C Wu","year":"2021","unstructured":"Wu C et al (2021) Bioinformatic analysis of the proteome in exosomes derived from plasma: exosomes involved in cholesterol metabolism process of patients with spinal cord injury in the acute phase. Front Neuroinform 15:662967","journal-title":"Front Neuroinform"},{"issue":"5","key":"3956_CR20","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1089\/wound.2019.0968","volume":"9","author":"M Baldan-Martin","year":"2020","unstructured":"Baldan-Martin M et al (2020) Comprehensive proteomic profiling of pressure ulcers in patients with spinal cord injury identifies a specific protein pattern of pathology. Adv Wound Care 9(5):277\u2013294 (New Rochelle)","journal-title":"Adv Wound Care"},{"key":"3956_CR21","doi-asserted-by":"crossref","unstructured":"Conlon DM et al (2022) Sortilin restricts secretion of apolipoprotein B-100 by hepatocytes under stressed but not basal conditions. J Clin Invest 132(6):e144334","DOI":"10.1172\/JCI144334"},{"issue":"43","key":"3956_CR22","doi-asserted-by":"publisher","first-page":"13435","DOI":"10.1523\/JNEUROSCI.3257-09.2009","volume":"29","author":"KA Kigerl","year":"2009","unstructured":"Kigerl KA et al (2009) Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 29(43):13435\u201313444","journal-title":"J Neurosci"},{"issue":"2","key":"3956_CR23","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s12035-012-8287-4","volume":"46","author":"S Karimi-Abdolrezaee","year":"2012","unstructured":"Karimi-Abdolrezaee S, Billakanti R (2012) Reactive astrogliosis after spinal cord injury-beneficial and detrimental effects. Mol Neurobiol 46(2):251\u2013264","journal-title":"Mol Neurobiol"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03956-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-03956-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03956-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T09:16:57Z","timestamp":1724404617000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-03956-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,10]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3956"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-03956-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,10]]},"assertion":[{"value":"30 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal studies were conformed to ethical standards and approved by the ethic committee of Nantong First People\u2019s Hospital.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}