{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:32:05Z","timestamp":1763706725845,"version":"3.37.3"},"reference-count":55,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s12035-024-03969-0","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T09:02:47Z","timestamp":1706605367000},"page":"6264-6278","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of the NMDA Currents by Probenecid in Amygdaloid Kindling Epilepsy Model"],"prefix":"10.1007","volume":"61","author":[{"given":"Edith","family":"Gonz\u00e1lez-Guevara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Lara-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Rendon-Ochoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Franco-P\u00e9rez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Hern\u00e1ndez-Cer\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Laville","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisca","family":"P\u00e9rez-Severiano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"Mart\u00ednez-de los Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica","family":"Custodio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Bargas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1374-1487","authenticated-orcid":false,"given":"Juan Carlos","family":"Mart\u00ednez-Lazcano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,1,30]]},"reference":[{"issue":"6069","key":"3969_CR1","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/321519a0","volume":"321","author":"AB MacDermott","year":"1986","unstructured":"MacDermott AB, Mayer ML, Westbrook GL, Smith SJ, Barker JL (1986) NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 321(6069):519\u2013522","journal-title":"Nature"},{"issue":"6104","key":"3969_CR2","doi-asserted-by":"publisher","first-page":"529","DOI":"10.1038\/325529a0","volume":"325","author":"JW Johnson","year":"1987","unstructured":"Johnson JW, Ascher P (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325(6104):529\u2013531","journal-title":"Nature"},{"issue":"5950","key":"3969_CR3","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/307462a0","volume":"307","author":"L Nowak","year":"1984","unstructured":"Nowak L, Bregestovski P, Ascher P, Herbet A, Prochiantz A (1984) Magnesium gates glutamate-activated channels in mouse central neurones. Nature 307(5950):462\u2013465","journal-title":"Nature"},{"issue":"5965","key":"3969_CR4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1038\/309261a0","volume":"309","author":"ML Mayer","year":"1984","unstructured":"Mayer ML, Westbrook GL, Guthrie PB (1984) Voltage-dependent block by Mg2+ of NMDA responses in spinal cord neurones. Nature 309(5965):261\u2013263","journal-title":"Nature"},{"issue":"2","key":"3969_CR5","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/0166-2236(95)80016-U","volume":"18","author":"GL Collingridge","year":"1995","unstructured":"Collingridge GL, Bliss TV (1995) Memories of NMDA receptors and LTP. Trends Neurosci 18(2):54\u201356","journal-title":"Trends Neurosci"},{"key":"3969_CR6","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/1756-6606-6-5","volume":"6","author":"TV Bliss","year":"2013","unstructured":"Bliss TV, Collingridge GL (2013) Expression of NMDA receptor-dependent LTP in the hippocampus: bridging the divide. Mol Brain 6:5","journal-title":"Mol Brain"},{"issue":"6114","key":"3969_CR7","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/326701a0","volume":"326","author":"I Mody","year":"1987","unstructured":"Mody I, Heinemann U (1987) NMDA receptors of dentate gyrus granule cells participate in synaptic transmission following kindling. Nature 326(6114):701\u20134","journal-title":"Nature"},{"issue":"2","key":"3969_CR8","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/S0092-8674(00)80921-6","volume":"92","author":"R Sprengel","year":"1998","unstructured":"Sprengel R, Suchanek B, Amico C et al (1998) Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo. Cell 92(2):279\u2013289","journal-title":"Cell"},{"issue":"6","key":"3969_CR9","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.neuropharm.2008.02.008","volume":"54","author":"JP Bankstahl","year":"2008","unstructured":"Bankstahl JP, Hoffmann K, Bethmann K, Loscher W (2008) Glutamate is critically involved in seizure-induced overexpression of P-glycoprotein in the brain. Neuropharmacology 54(6):1006\u20131016","journal-title":"Neuropharmacology"},{"issue":"9","key":"3969_CR10","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.1021\/mp4001102","volume":"10","author":"J Avemary","year":"2013","unstructured":"Avemary J, Salvamoser JD, Peraud A et al (2013) Dynamic regulation of P-glycoprotein in human brain capillaries. Mol Pharm 10(9):3333\u20133341","journal-title":"Mol Pharm"},{"issue":"1","key":"3969_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1528-1157.1995.tb01657.x","volume":"36","author":"DM Tishler","year":"1995","unstructured":"Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C (1995) MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36(1):1\u20136","journal-title":"Epilepsia"},{"issue":"21","key":"3969_CR12","doi-asserted-by":"publisher","first-page":"11696","DOI":"10.3390\/ijms222111696","volume":"22","author":"B Smolarz","year":"2021","unstructured":"Smolarz B, Makowska M, Romanowicz H (2021) Pharmacogenetics of Drug-Resistant Epilepsy (Review of Literature). Int J Mol Sci 22(21):11696","journal-title":"Int J Mol Sci"},{"issue":"4","key":"3969_CR13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1016\/S0887-8994(99)00074-0","volume":"21","author":"A Lazarowski","year":"1999","unstructured":"Lazarowski A, Sevlever G, Taratuto A, Massaro M, Rabinowicz A (1999) Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol 21(4):731\u2013734","journal-title":"Pediatr Neurol"},{"issue":"16","key":"3969_CR14","doi-asserted-by":"publisher","first-page":"3437","DOI":"10.1097\/00001756-199911080-00032","volume":"10","author":"SM Sisodiya","year":"1999","unstructured":"Sisodiya SM, Heffernan J, Squier MV (1999) Over-expression of P-glycoprotein in malformations of cortical development. NeuroReport 10(16):3437\u20133441","journal-title":"NeuroReport"},{"issue":"12","key":"3969_CR15","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1046\/j.1528-1157.2001.12301.x","volume":"42","author":"SM Dombrowski","year":"2001","unstructured":"Dombrowski SM, Desai SY, Marroni M et al (2001) Overexpression of multiple drug resistance genes in endothelial cells from patients with refractory epilepsy. Epilepsia 42(12):1501\u20131506","journal-title":"Epilepsia"},{"issue":"2","key":"3969_CR16","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/S0887-8994(03)00407-7","volume":"30","author":"A Lazarowski","year":"2004","unstructured":"Lazarowski A, Lubieniecki F, Camarero S et al (2004) Multidrug resistance proteins in tuberous sclerosis and refractory epilepsy. Pediatr Neurol 30(2):102\u2013106","journal-title":"Pediatr Neurol"},{"issue":"1","key":"3969_CR17","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1097\/00007691-200402000-00010","volume":"26","author":"A Lazarowski","year":"2004","unstructured":"Lazarowski A, Massaro M, Schteinschnaider A, Intruvini S, Sevlever G, Rabinowicz A (2004) Neuronal MDR-1 gene expression and persistent low levels of anticonvulsants in a child with refractory epilepsy. Ther Drug Monit 26(1):44\u201346","journal-title":"Ther Drug Monit"},{"issue":"11","key":"3969_CR18","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1016\/j.lfs.2004.02.027","volume":"75","author":"HJ Zhu","year":"2004","unstructured":"Zhu HJ, Liu GQ (2004) Glutamate up-regulates P-glycoprotein expression in rat brain microvessel endothelial cells by an NMDA receptor-mediated mechanism. Life Sci 75(11):1313\u20131322","journal-title":"Life Sci"},{"issue":"3","key":"3969_CR19","first-page":"3418","volume":"8","author":"T Yang","year":"2015","unstructured":"Yang T, Kong B, Kuang Y et al (2015) Emodin plays an interventional role in epileptic rats via multidrug resistance gene 1 (MDR1). Int J Clin Exp Pathol 8(3):3418\u20133425","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"3969_CR20","doi-asserted-by":"publisher","first-page":"104","DOI":"10.4062\/biomolther.2019.047","volume":"28","author":"MH Cheng","year":"2020","unstructured":"Cheng MH, Kim SJ (2020) Inhibitory Effect of Probenecid on Osteoclast Formation via JNK, ROS and COX-2. Biomol Ther (Seoul) 28(1):104\u2013109","journal-title":"Biomol Ther (Seoul)"},{"issue":"20","key":"3969_CR21","doi-asserted-by":"publisher","first-page":"1913","DOI":"10.1089\/neu.2015.4342","volume":"33","author":"L Du","year":"2016","unstructured":"Du L, Empey PE, Ji J et al (2016) Probenecid and N-Acetylcysteine Prevent Loss of Intracellular Glutathione and Inhibit Neuronal Death after Mechanical Stretch Injury In Vitro. J Neurotrauma 33(20):1913\u20131917","journal-title":"J Neurotrauma"},{"issue":"6","key":"3969_CR22","first-page":"2197","volume":"34","author":"B Jiang","year":"2021","unstructured":"Jiang B, Zhao Y, Cao J et al (2021) Synthesis and preliminary biological evaluation of naproxen-probenecid conjugate for central nervous system (CNS) delivery. Pak J Pharm Sci 34(6):2197\u20132203","journal-title":"Pak J Pharm Sci"},{"issue":"9","key":"3969_CR23","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1007\/s00702-009-0253-6","volume":"116","author":"E Vamos","year":"2009","unstructured":"Vamos E, Voros K, Zadori D, Vecsei L, Klivenyi P (2009) Neuroprotective effects of probenecid in a transgenic animal model of Huntington\u2019s disease. J Neural Transm (Vienna) 116(9):1079\u20131086","journal-title":"J Neural Transm (Vienna)"},{"key":"3969_CR24","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.neulet.2007.08.035","volume":"425","author":"S Bang","year":"2007","unstructured":"Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425:120\u2013125","journal-title":"Neurosci Lett"},{"key":"3969_CR25","doi-asserted-by":"publisher","first-page":"C761","DOI":"10.1152\/ajpcell.00227.2008","volume":"295","author":"LS SilvermanW","year":"2008","unstructured":"SilvermanW LS, Dahl G (2008) Probenecid, a gout remedy, inhibits pannexin 1 channels. Am J Physiol Cell Physiol 295:C761\u2013C767","journal-title":"Am J Physiol Cell Physiol"},{"issue":"1\u20132","key":"3969_CR26","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/S0006-8993(97)00434-4","volume":"764","author":"DL Taylor","year":"1997","unstructured":"Taylor DL, Urenjak J, Zilkha E, Obrenovitch TP (1997) Effects of probenecid on the elicitation of spreading depression in the rat striatum. Brain Res 764(1\u20132):117\u2013125","journal-title":"Brain Res"},{"issue":"1","key":"3969_CR27","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1007\/PL00004915","volume":"355","author":"J Urenjak","year":"1997","unstructured":"Urenjak J, Obrenovitch TP, Zilkha E (1997) Effect of probenecid on depolarizations evoked by N-methyl-D-aspartate (NMDA) in the rat striatum. Naunyn Schmiedebergs Arch Pharmacol 355(1):36\u201342","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"3969_CR28","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"2013","unstructured":"Paxinos G, Watson CH (2013) The Rat Brain in Stereotaxic Coordinates, 7th edn. Academic Press, New York","edition":"7"},{"issue":"7","key":"3969_CR29","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1002\/jnr.23974","volume":"95","author":"M Hernandez-Ceron","year":"2017","unstructured":"Hernandez-Ceron M, Martinez-Lazcano JC, Rubio C et al (2017) Participation of the dentate-rubral pathway in the kindling model of epilepsy. J Neurosci Res 95(7):1495\u20131502","journal-title":"J Neurosci Res"},{"issue":"3","key":"3969_CR30","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1016\/0014-4886(69)90128-9","volume":"25","author":"GV Goddard","year":"1969","unstructured":"Goddard GV, McIntyre DC, Leech CK (1969) A permanent change in brain function resulting from daily electrical stimulation. Exp Neurol 25(3):295\u2013330","journal-title":"Exp Neurol"},{"issue":"3","key":"3969_CR31","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","volume":"32","author":"RJ Racine","year":"1972","unstructured":"Racine RJ (1972) Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroencephalogr Clin Neurophysiol 32(3):281\u201394","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"3969_CR32","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.niox.2018.02.004","volume":"75","author":"JC Martinez-Lazcano","year":"2018","unstructured":"Martinez-Lazcano JC, Gonzalez-Guevara E, Custodio V et al (2018) Activity of nitric oxide synthase isoforms in acute brain oxidative damage induced by ozone exposure. Nitric Oxide 75:42\u201352","journal-title":"Nitric Oxide"},{"issue":"7","key":"3969_CR33","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1002\/jnr.21261","volume":"85","author":"JC Martinez-Lazcano","year":"2007","unstructured":"Martinez-Lazcano JC, Perez-Severiano F, Escalante B et al (2007) Selective protection against oxidative damage in brain of mice with a targeted disruption of the neuronal nitric oxide synthase gene. J Neurosci Res 85(7):1391\u20131402","journal-title":"J Neurosci Res"},{"issue":"11 Pt 1","key":"3969_CR34","doi-asserted-by":"publisher","first-page":"6667","DOI":"10.1523\/JNEUROSCI.14-11-06667.1994","volume":"14","author":"J Bargas","year":"1994","unstructured":"Bargas J, Howe A, Eberwine J, Cao Y, Surmeier DJ (1994) Cellular and molecular characterization of Ca2+ currents in acutely isolated, adult rat neostriatal neurons. J Neurosci 14(11 Pt 1):6667\u20136686","journal-title":"J Neurosci"},{"issue":"5","key":"3969_CR35","doi-asserted-by":"publisher","first-page":"2246","DOI":"10.1152\/jn.1994.72.5.2246","volume":"72","author":"J Flores-Hernandez","year":"1994","unstructured":"Flores-Hernandez J, Galarraga E, Pineda JC, Bargas J (1994) Patterns of excitatory and inhibitory synaptic transmission in the rat neostriatum as revealed by 4-AP. J Neurophysiol 72(5):2246\u20132256","journal-title":"J Neurophysiol"},{"issue":"1","key":"3969_CR36","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s12868-018-0441-0","volume":"19","author":"EA Rendon-Ochoa","year":"2018","unstructured":"Rendon-Ochoa EA, Hernandez-Flores T, Aviles-Rosas VH et al (2018) Calcium currents in striatal fast-spiking interneurons: dopaminergic modulation of CaV1 channels. BMC Neurosci 19(1):42","journal-title":"BMC Neurosci"},{"issue":"6","key":"3969_CR37","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1152\/jn.00361.2002","volume":"88","author":"J Flores-Hernandez","year":"2002","unstructured":"Flores-Hernandez J, Cepeda C, Hernandez-Echeagaray E et al (2002) Dopamine enhancement of NMDA currents in dissociated medium-sized striatal neurons: role of D1 receptors and DARPP-32. J Neurophysiol 88(6):3010\u20133020","journal-title":"J Neurophysiol"},{"issue":"3","key":"3969_CR38","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3109\/07357907.2016.1139717","volume":"34","author":"D Campos-Arroyo","year":"2016","unstructured":"Campos-Arroyo D, Maldonado V, Bahena I et al (2016) Probenecid Sensitizes Neuroblastoma Cancer Stem Cells to Cisplatin. Cancer Invest 34(3):155\u201366","journal-title":"Cancer Invest"},{"issue":"1","key":"3969_CR39","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1111\/j.1600-0404.1980.tb03002.x","volume":"62","author":"E Leino","year":"1980","unstructured":"Leino E, MacDonald E, Airaksinen MM, Riekkinen PJ (1980) Homovanillic acid and 5-hydroxyindoleacetic acid levels in cerebrospinal fluid of patients with progressive myoclonus epilepsy. Acta Neurol Scand 62(1):41\u201354","journal-title":"Acta Neurol Scand"},{"issue":"6","key":"3969_CR40","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1111\/j.1469-8749.1980.tb03741.x","volume":"22","author":"BA Shaywitz","year":"1980","unstructured":"Shaywitz BA, Cohen DJ, Leckman JF, Young JG, Bowers MB (1980) Ontogeny of dopamine and serotonin metabolites in the cerebrospinal fluid of children with neurological disorders. Dev Med Child Neurol 22(6):748\u2013754","journal-title":"Dev Med Child Neurol"},{"issue":"1","key":"3969_CR41","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/S0387-7604(82)80103-4","volume":"4","author":"Y Fukuyama","year":"1982","unstructured":"Fukuyama Y, Ochiai Y (1982) Therapeutic trial by taurine for intractable childhood epilepsies. Brain Dev 4(1):63\u201369","journal-title":"Brain Dev"},{"issue":"16","key":"3969_CR42","doi-asserted-by":"publisher","first-page":"6445","DOI":"10.1073\/pnas.87.16.6445","volume":"87","author":"CM Tang","year":"1990","unstructured":"Tang CM, Dichter M, Morad M (1990) Modulation of the N-methyl-D-aspartate channel by extracellular H+. Proc Natl Acad Sci U S A 87(16):6445\u20136449","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"9","key":"3969_CR43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1056\/NEJM199403033300907","volume":"330","author":"SA Lipton","year":"1994","unstructured":"Lipton SA, Rosenberg PA (1994) Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330(9):613\u2013622","journal-title":"N Engl J Med"},{"issue":"20","key":"3969_CR44","doi-asserted-by":"publisher","first-page":"11024","DOI":"10.1073\/pnas.191352298","volume":"98","author":"AE West","year":"2001","unstructured":"West AE, Chen WG et al (2001) Calcium regulation of neuronal gene expression. Proc Natl Acad Sci U S A 98(20):11024\u201311031","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"3969_CR45","doi-asserted-by":"publisher","first-page":"808","DOI":"10.2174\/187152711798072347","volume":"10","author":"M Banach","year":"2011","unstructured":"Banach M, Piskorska B, Czuczwar SJ, Borowicz KK (2011) Nitric oxide, epileptic seizures, and action of antiepileptic drugs. CNS Neurol Disord Drug Targets 10(7):808\u2013819","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"8","key":"3969_CR46","doi-asserted-by":"publisher","first-page":"1328","DOI":"10.2967\/jnumed.108.051235","volume":"49","author":"JP Bankstahl","year":"2008","unstructured":"Bankstahl JP, Kuntner C, Abrahim A et al (2008) Langer, Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET. J Nucl Med 49(8):1328\u20131335","journal-title":"J Nucl Med"},{"issue":"2\u20133","key":"3969_CR47","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.eplepsyres.2004.07.001","volume":"60","author":"TP Sutula","year":"2004","unstructured":"Sutula TP (2004) Mechanisms of epilepsy progression: current theories and perspectives from neuroplasticity in adulthood and development. Epilepsy Res 60(2\u20133):161\u2013171","journal-title":"Epilepsy Res"},{"key":"3969_CR48","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/S0079-6123(07)63029-5","volume":"163","author":"TP Sutula","year":"2007","unstructured":"Sutula TP, Dudek FE (2007) Unmasking recurrent excitation generated by mossy fiber sprouting in the epileptic dentate gyrus: an emergent property of a complex system. Prog Brain Res 163:541\u2013563","journal-title":"Prog Brain Res"},{"issue":"3","key":"3969_CR49","doi-asserted-by":"publisher","first-page":"S175","DOI":"10.1111\/j.1440-1819.1995.tb02167.x","volume":"49","author":"JO McNamara","year":"1995","unstructured":"McNamara JO (1995) Analyses of the molecular basis of kindling development. Psychiatry Clin Neurosci 49(3):S175\u2013S178","journal-title":"Psychiatry Clin Neurosci"},{"issue":"8","key":"3969_CR50","doi-asserted-by":"publisher","first-page":"3612","DOI":"10.1523\/JNEUROSCI.13-08-03612.1993","volume":"13","author":"G Kohr","year":"1993","unstructured":"Kohr G, De Koninck Y, Mody I (1993) Properties of NMDA receptor channels in neurons acutely isolated from epileptic (kindled) rats. J Neurosci 13(8):3612\u20133627","journal-title":"J Neurosci"},{"issue":"Suppl 6","key":"3969_CR51","first-page":"S100","volume":"41","author":"J Behr","year":"2000","unstructured":"Behr J, Heinemann U, Mody I (2000) Glutamate receptor activation in the kindled dentate gyrus. Epilepsia 41(Suppl 6):S100\u2013S103","journal-title":"Epilepsia"},{"issue":"1\u20132","key":"3969_CR52","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/0304-3940(92)90802-E","volume":"148","author":"W Kamphuis","year":"1992","unstructured":"Kamphuis W, Monyer H, De Rijk TC, Lopes da Silva FH (1992) Hippocampal kindling increases the expression of glutamate receptor-A Flip and -B Flip mRNA in dentate granule cells. Neurosci Lett 148(1\u20132):51\u201354","journal-title":"Neurosci Lett"},{"issue":"4","key":"3969_CR53","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/aps.2012.183","volume":"34","author":"YH Chen","year":"2013","unstructured":"Chen YH, Wang CC, Xiao X, Wei L, Xu G (2013) Multidrug resistance-associated protein 1 decreases the concentrations of antiepileptic drugs in cortical extracellular fluid in amygdale kindling rats. Acta Pharmacol Sin 34(4):473\u2013479","journal-title":"Acta Pharmacol Sin"},{"issue":"5","key":"3969_CR54","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1124\/mol.107.041210","volume":"73","author":"B Bauer","year":"2008","unstructured":"Bauer B, Hartz AM, Pekcec A, Toellner K, Miller DS, Potschka H (2008) Seizure-induced up-regulation of P-glycoprotein at the blood-brain barrier through glutamate and cyclooxygenase-2 signaling. Mol Pharmacol 73(5):1444\u20131453","journal-title":"Mol Pharmacol"},{"issue":"6","key":"3969_CR55","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.3390\/biomedicines11061516","volume":"11","author":"C Garc\u00eda-Rodr\u00edguez","year":"2023","unstructured":"Garc\u00eda-Rodr\u00edguez C, Mujica P, Illanes-Gonz\u00e1lez J, L\u00f3pez A, Vargas C et al (2023) Probenecid, an Old Drug with Potential New Uses for Central Nervous System Disorders and Neuroinflammation. Biomedicines 11(6):1516","journal-title":"Biomedicines"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03969-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-03969-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03969-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T09:10:51Z","timestamp":1724404251000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-03969-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,30]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3969"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-03969-0","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"type":"print","value":"0893-7648"},{"type":"electronic","value":"1559-1182"}],"subject":[],"published":{"date-parts":[[2024,1,30]]},"assertion":[{"value":"24 May 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was conducted in accordance with the institutional guidelines and national regulation (NOM-062-ZOO-1999) from the Guide for the Care and Use of Laboratory Animals (8th edition), and international guiding principles (Council for International Organizations of Medical Sciences, CIOMS)","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests or financial interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}