{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:10:33Z","timestamp":1789103433418,"version":"build-2803163510"},"reference-count":121,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pathogenesis of schizophrenia begins in early neurodevelopment and leads to excitatory-inhibitory imbalance. It is therefore essential that preclinical models used to understand disease, select drug targets and evaluate novel therapeutics encompass similar neurochemical deficits. One approach to improved preclinical modelling incorporates dual-hit neurodevelopmental insults, like neonatal administration of phencyclidine (PCP, to disrupt development of glutamatergic circuitry) then post-weaning isolation (Iso, to mimic adolescent social stress). We recently showed that male Lister-hooded rats exposed to PCP-Iso exhibit reduced hippocampal expression of the GABA interneuron marker calbindin. The current study expanded on this by investigating changes to additional populations of GABAergic interneurons in frontal cortical and hippocampal tissue from the same animals (by immunohistochemistry) as well as levels of GABA itself (via ELISA). Because inflammatory changes are also implicated in schizophrenia, we performed additional immunohistochemical evaluations of Iba-1 positive microglia as well as ELISA analysis of IL-6 in the same brain regions. Single-hit isolation-reared and dual-hit PCP-Iso rats both showed reduced parvalbumin immunoreactivity in the prelimbic\/infralimbic region of the frontal cortex. However, this was more widespread in PCP-Iso, extending to the medial\/ventral and lateral\/dorsolateral orbitofrontal cortices. Loss of GABAergic markers was accompanied by increased microglial activation in the medial\/ventral orbitofrontal cortices of PCP-Iso, together with frontal cortical IL-6 elevations not seen following single-hit isolation rearing. These findings enhance the face validity of PCP-Iso, and we advocate the use of this preclinical model for future evaluation of novel therapeutics\u2014especially those designed to normalise excitatory-inhibitory imbalance or reduce neuroinflammation.<\/jats:p>","DOI":"10.1007\/s12035-024-03987-y","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T11:03:11Z","timestamp":1708081391000},"page":"6968-6983","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["GABAergic and inflammatory changes in the frontal cortex following neonatal PCP plus isolation rearing, as a dual-hit neurodevelopmental model for schizophrenia"],"prefix":"10.1007","volume":"61","author":[{"given":"Jennifer A.","family":"Cale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan J.","family":"Chauhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Cleaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthoio R.","family":"Fusciardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"McCann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah C.","family":"Waters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju\u0161","family":"\u017davbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9290-9024","authenticated-orcid":false,"given":"Madeleine V.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,2,16]]},"reference":[{"key":"3987_CR1","doi-asserted-by":"publisher","unstructured":"Velligan DI, Rao S (2023) The epidemiology and global burden of schizophrenia. J Clin Psychiatry 84:MS21078COM5. https:\/\/doi.org\/10.4088\/JCP.MS21078COM5","DOI":"10.4088\/JCP.MS21078COM5"},{"key":"3987_CR2","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/s41398-022-01904-2","volume":"12","author":"DL Spark","year":"2022","unstructured":"Spark DL, Fornito A, Langmead CJ, Stewart GD (2022) Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics. Transl Psychiatry 12:147. https:\/\/doi.org\/10.1038\/s41398-022-01904-2","journal-title":"Transl Psychiatry"},{"key":"3987_CR3","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.biopsych.2022.06.017","volume":"92","author":"OD Howes","year":"2022","unstructured":"Howes OD, Shatalina E (2022) Integrating the neurodevelopmental and dopamine hypotheses of schizophrenia and the role of cortical excitation-inhibition balance. Biol Psychiatry 92:501\u2013513. https:\/\/doi.org\/10.1016\/j.biopsych.2022.06.017","journal-title":"Biol Psychiatry"},{"key":"3987_CR4","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.biopsych.2008.11.019","volume":"65","author":"N Mellios","year":"2009","unstructured":"Mellios N, Huang HS, Baker SP, Galdzicka M, Ginns E, Akbarian S (2009) Molecular determinants of dysregulated GABAergic gene expression in the prefrontal cortex of subjects with schizophrenia. Biol Psychiatry 65:1006\u20131014. https:\/\/doi.org\/10.1016\/j.biopsych.2008.11.019","journal-title":"Biol Psychiatry"},{"key":"3987_CR5","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.schres.2011.06.007","volume":"131","author":"C Konradi","year":"2011","unstructured":"Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S (2011) Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res 131:165\u2013173. https:\/\/doi.org\/10.1016\/j.schres.2011.06.007","journal-title":"Schizophr Res"},{"key":"3987_CR6","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.schres.2014.02.021","volume":"155","author":"SJ Fung","year":"2014","unstructured":"Fung SJ, Fillman SG, Webster MJ, Shannon Weickert C (2014) Schizophrenia and bipolar disorder show both common and distinct changes in cortical interneuron markers. Schizophr Res 155:26\u201330. https:\/\/doi.org\/10.1016\/j.schres.2014.02.021","journal-title":"Schizophr Res"},{"key":"3987_CR7","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1093\/schbul\/sbt178","volume":"41","author":"GD Hoftman","year":"2015","unstructured":"Hoftman GD, Volk DW, Bazmi HH, Li S, Sampson AR, Lewis DA (2015) Altered cortical expression of GABA-related genes in schizophrenia: illness progression vs developmental disturbance. Schizophr Bull 41:180\u2013191. https:\/\/doi.org\/10.1093\/schbul\/sbt178","journal-title":"Schizophr Bull"},{"key":"3987_CR8","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1176\/appi.ajp.2015.15020150","volume":"173","author":"DW Chung","year":"2016","unstructured":"Chung DW, Volk DW, Arion D, Zhang Y, Sampson AR, Lewis DA (2016) Dysregulated ErbB4 splicing in schizophrenia: selective effects on parvalbumin expression. Am J Psychiatry 173:60\u201368. https:\/\/doi.org\/10.1176\/appi.ajp.2015.15020150","journal-title":"Am J Psychiatry"},{"key":"3987_CR9","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1016\/S0920-9964(96)00122-3","volume":"24","author":"CL Beasley","year":"1997","unstructured":"Beasley CL, Reynolds GP (1997) Parvalbumin-immunoreactive neurons are reduced in the prefrontal cortex of schizophrenics. Schizophr Res 24:349\u2013355. https:\/\/doi.org\/10.1016\/S0920-9964(96)00122-3","journal-title":"Schizophr Res"},{"key":"3987_CR10","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/mp.2013.152","volume":"19","author":"JR Glausier","year":"2014","unstructured":"Glausier JR, Fish KN, Lewis DA (2014) Altered parvalbumin basket cell inputs in the dorsolateral prefrontal cortex of schizophrenia subjects. Mol Psychiatry 19:30\u201336. https:\/\/doi.org\/10.1038\/mp.2013.152","journal-title":"Mol Psychiatry"},{"key":"3987_CR11","doi-asserted-by":"publisher","first-page":"2206","DOI":"10.1038\/npp.2016.24","volume":"41","author":"JF Enwright","year":"2016","unstructured":"Enwright JF, Sanapala S, Foglio A, Berry R, Fish KN, Lewis DA (2016) Reduced labeling of parvalbumin neurons and perineuronal nets in the dorsolateral prefrontal cortex of subjects with schizophrenia. Neuropsychopharmacology 41:2206\u20132214. https:\/\/doi.org\/10.1038\/npp.2016.24","journal-title":"Neuropsychopharmacology"},{"key":"3987_CR12","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1111\/bph.13364","volume":"173","author":"LE Laskaris","year":"2016","unstructured":"Laskaris LE, Di Biase MA, Everall I, Chana G, Christopoulos A, Skafidas E, Cropley VL, Pantelis C (2016) Microglial activation and progressive brain changes in schizophrenia. Br J Pharmacol 173:666\u2013680. https:\/\/doi.org\/10.1111\/bph.13364","journal-title":"Br J Pharmacol"},{"key":"3987_CR13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1093\/jnen\/59.2.137","volume":"59","author":"K Radewicz","year":"2000","unstructured":"Radewicz K, Garey LJ, Gentleman SM, Reynolds R (2000) Increase in HLA-DR immunoreactive microglia in frontal and temporal cortex of chronic schizophrenics. J Neuropathol Exp Neurol 59:137\u2013150. https:\/\/doi.org\/10.1093\/jnen\/59.2.137","journal-title":"J Neuropathol Exp Neurol"},{"key":"3987_CR14","first-page":"81","volume":"43","author":"T Wierzba-Bobrowicz","year":"2005","unstructured":"Wierzba-Bobrowicz T, Lewandowska E, Lechowicz W, Stepie\u0144 T, Pasennik E (2005) Quantitative analysis of activated microglia, ramified and damage of processes in the frontal and temporal lobes of chronic schizophrenics. Folia Neuropathol 43:81\u201389","journal-title":"Folia Neuropathol"},{"key":"3987_CR15","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1038\/mp.2012.110","volume":"18","author":"SG Fillman","year":"2013","unstructured":"Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, McCrossin T, Cairns M, Weickert CS (2013) Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia. Mol Psychiatry 18:206\u2013214. https:\/\/doi.org\/10.1038\/mp.2012.110","journal-title":"Mol Psychiatry"},{"key":"3987_CR16","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1503\/jpn.130277","volume":"39","author":"C Hercher","year":"2014","unstructured":"Hercher C, Chopra V, Beasley CL (2014) Evidence for morphological alterations in prefrontal white matter glia in schizophrenia and bipolar disorder. J Psychiatry Neurosci 39:376\u2013385. https:\/\/doi.org\/10.1503\/jpn.130277","journal-title":"J Psychiatry Neurosci"},{"key":"3987_CR17","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.schres.2017.04.043","volume":"192","author":"GN Pandey","year":"2018","unstructured":"Pandey GN, Rizavi HS, Zhang H, Ren X (2018) Abnormal gene and protein expression of inflammatory cytokines in the postmortem brain of schizophrenia patients. Schizophr Res 192:247\u2013254. https:\/\/doi.org\/10.1016\/j.schres.2017.04.043","journal-title":"Schizophr Res"},{"key":"3987_CR18","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1038\/npp.2013.38","volume":"38","author":"K Takao","year":"2013","unstructured":"Takao K, Kobayashi K, Hagihara H, Ohira K, Shoji H, Hattori S, Koshimizu H, Umemori J, Toyama K, Nakamura HK, Kuroiwa M, Maeda J, Atsuzawa K, Esaki K, Yamaguchi S, Furuya S, Takagi T, Walton NM, Hayashi N, Suzuki H, Higuchi M, Usuda N, Suhara T, Nishi A, Matsumoto M, Ishii S, Miyakawa T (2013) Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia. Neuropsychopharmacology 38:1409\u20131425. https:\/\/doi.org\/10.1038\/npp.2013.38","journal-title":"Neuropsychopharmacology"},{"key":"3987_CR19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029754","volume":"7","author":"G Ducharme","year":"2012","unstructured":"Ducharme G, Lowe GC, Goutagny R, Williams S (2012) Early alterations in hippocampal circuitry and theta rhythm generation in a mouse model of prenatal infection: implications for schizophrenia. PLoS ONE 7:e29754. https:\/\/doi.org\/10.1371\/journal.pone.0029754","journal-title":"PLoS ONE"},{"key":"3987_CR20","doi-asserted-by":"publisher","first-page":"987","DOI":"10.1021\/cn5003368","volume":"6","author":"M M\u00f6ller","year":"2015","unstructured":"M\u00f6ller M, Swanepoel T, Harvey BH (2015) Neurodevelopmental animal models reveal the convergent role of neurotransmitter systems, inflammation, and oxidative stress as biomarkers of schizophrenia: implications for novel drug development. ACS Chem Neurosci 6:987\u20131016. https:\/\/doi.org\/10.1021\/cn5003368","journal-title":"ACS Chem Neurosci"},{"key":"3987_CR21","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1126\/science.283.5398.70","volume":"283","author":"C Ikonomidou","year":"1999","unstructured":"Ikonomidou C, Bosch F, Miksa M, Bittigau P, V\u00f6ckler J, Dikranian K, Tenkova TI, Stefovska V, Turski L, Olney JW (1999) Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 283:70\u201374. https:\/\/doi.org\/10.1126\/science.283.5398.70","journal-title":"Science"},{"key":"3987_CR22","first-page":"A70","volume":"25S","author":"PL Gaskin","year":"2011","unstructured":"Gaskin PL, Alexander SP, Fone KC (2011) Combining rearing in social isolation with perinatal PCP treatment as a preclinical model of schizophrenia. J Psychopharmacol 25S:A70","journal-title":"J Psychopharmacol"},{"key":"3987_CR23","doi-asserted-by":"publisher","first-page":"1252","DOI":"10.1177\/0269881111430751","volume":"26","author":"AL Lim","year":"2012","unstructured":"Lim AL, Taylor DA, Malone DT (2012) A two-hit model: behavioural investigation of the effect of combined neonatal MK-801 administration and isolation rearing in the rat. J Psychopharmacol 26:1252\u20131264. https:\/\/doi.org\/10.1177\/0269881111430751","journal-title":"J Psychopharmacol"},{"key":"3987_CR24","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.nbd.2013.07.008","volume":"59","author":"J Gilabert-Juan","year":"2013","unstructured":"Gilabert-Juan J, Belles M, Saez AR, Carceller H, Zamarbide-Fores S, Molt\u00f3 MD, Nacher J (2013) A \u201cdouble hit\u201d murine model for schizophrenia shows alterations in the structure and neurochemistry of the medial prefrontal cortex and the hippocampus. Neurobiol Dis 59:126\u2013140. https:\/\/doi.org\/10.1016\/j.nbd.2013.07.008","journal-title":"Neurobiol Dis"},{"key":"3987_CR25","doi-asserted-by":"publisher","first-page":"2533","DOI":"10.1007\/s00213-013-3424-y","volume":"231","author":"PL Gaskin","year":"2014","unstructured":"Gaskin PL, Alexander SP, Fone KC (2014) Neonatal phencyclidine administration and post-weaning social isolation as a dual-hit model of \u201cschizophrenia-like\u201d behaviour in the rat. Psychopharmacology 231:2533\u20132545. https:\/\/doi.org\/10.1007\/s00213-013-3424-y","journal-title":"Psychopharmacology"},{"key":"3987_CR26","doi-asserted-by":"crossref","unstructured":"Kohli S, Alberati D, Ballard TM, Steward LJ, King MV, Fone KCF (2016) The GlyT1 inhibitor RO4993850 alters social behavior and ultrasonic vocalization calls in a neonatal-phencyclidine isolation-reared rat model for schizophrenia. Eur Neuropsychopharmacol 26:S494\u2013S495. Also available online at https:\/\/www.ecnp.eu\/presentationpdfs\/70\/P.3.a.012.pdf. Accessed 19 May 2023","DOI":"10.1016\/S0924-977X(16)31508-5"},{"key":"3987_CR27","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.euroneuro.2015.12.020","volume":"26","author":"DJG Watson","year":"2016","unstructured":"Watson DJG, King MV, Gyerty\u00e1n I, Kiss B, Adham N, Fone KCF (2016) The dopamine D3-preferring D2\/D3 dopamine receptor partial agonist, cariprazine, reverses behavioural changes in a rat neurodevelopmental model for schizophrenia. Eur Neuropsychopharmacol 26:208\u2013224. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.12.020","journal-title":"Eur Neuropsychopharmacol"},{"key":"3987_CR28","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1476-5381.2011.01386.x","volume":"164","author":"CA Jones","year":"2011","unstructured":"Jones CA, Watson DJ, Fone KC (2011) Animal models of schizophrenia. Br J Pharmacol 164:1162\u20131194. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01386.x","journal-title":"Br J Pharmacol"},{"key":"3987_CR29","doi-asserted-by":"publisher","unstructured":"Gaskin PL, Toledo-Rodriguez M, Alexander SP, Fone KC (2016) Down-regulation of hippocampal genes regulating dopaminergic, GABAergic, and glutamatergic function following combined neonatal phencyclidine and post-weaning social isolation of rats as a neurodevelopmental model for schizophrenia. Int J Neuropsychopharmacol 19:pyw062. https:\/\/doi.org\/10.1093\/ijnp\/pyw062","DOI":"10.1093\/ijnp\/pyw062"},{"key":"3987_CR30","doi-asserted-by":"publisher","first-page":"3439","DOI":"10.1007\/s12035-020-01938-x","volume":"57","author":"SE Shortall","year":"2020","unstructured":"Shortall SE, Brown AM, Newton-Mann E, Dawe-Lane E, Evans C, Fowler M, King MV (2020) Calbindin deficits may underlie dissociable effects of 5-HT6 and mGlu7 antagonists on glutamate and cognition in a dual-hit neurodevelopmental model for schizophrenia. Mol Neurobiol 57:3439\u20133457. https:\/\/doi.org\/10.1007\/s12035-020-01938-x","journal-title":"Mol Neurobiol"},{"key":"3987_CR31","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S0278-5846(99)00005-6","volume":"23","author":"S Iritani","year":"1999","unstructured":"Iritani S, Kuroki N, Ikeda K, Kazamatsuri H (1999) Calbindin immunoreactivity in the hippocampal formation and neocortex of schizophrenics. Prog Neuropsychopharmacol Biol Psychiatry 23:409\u2013421. https:\/\/doi.org\/10.1016\/S0278-5846(99)00005-6","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3987_CR32","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.biopsych.2005.03.031","volume":"58","author":"CA Altar","year":"2005","unstructured":"Altar CA, Jurata LW, Charles V, Lemire A, Liu P, Bukhman Y, Young TA, Bullard J, Yokoe H, Webster MJ, Knable MB, Brockman JA (2005) Deficient hippocampal neuron expression of proteasome, ubiquitin, and mitochondrial genes in multiple schizophrenia cohorts. Biol Psychiatry 58:85\u201396. https:\/\/doi.org\/10.1016\/j.biopsych.2005.03.031","journal-title":"Biol Psychiatry"},{"key":"3987_CR33","doi-asserted-by":"publisher","first-page":"3617","DOI":"10.1111\/bph.15193","volume":"177","author":"N Percie du Sert","year":"2020","unstructured":"Percie du Sert N, Hurst V, Ahluwalia A, Alam S, Avey MT, Baker M, Browne WJ, Clark A, Cuthill IC, Dirnagl U, Emerson M, Garner P, Holgate ST, Howells DW, Karp NA, Lazic SE, Lidster K, MacCallum CJ, Macleod M, Pearl EJ, Petersen OH, Rawle F, Reynolds P, Rooney K, Sena ES, Silberberg SD, Steckler T, W\u00fcrbel H (2020) The ARRIVE guidelines 2.0: updated guidelines for reporting animal research. Br J Pharmacol 177:3617\u20133624. https:\/\/doi.org\/10.1111\/bph.15193","journal-title":"Br J Pharmacol"},{"key":"3987_CR34","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1007\/BF03188770","volume":"8","author":"S Chakrabarti","year":"1983","unstructured":"Chakrabarti S, Law FC (1983) The dispositional kinetics of phencyclidine and its N-ethylamine analogue in rats. Eur J Drug Metab Pharmacokinet 8:383\u2013388. https:\/\/doi.org\/10.1007\/BF03188770","journal-title":"Eur J Drug Metab Pharmacokinet"},{"key":"3987_CR35","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.neubiorev.2008.03.003","volume":"32","author":"KC Fone","year":"2008","unstructured":"Fone KC, Porkess MV (2008) Behavioural and neurochemical effects of post-weaning social isolation in rodents-relevance to developmental neuropsychiatric disorders. Neurosci Biobehav Rev 32:1087\u20131102. https:\/\/doi.org\/10.1016\/j.neubiorev.2008.03.003","journal-title":"Neurosci Biobehav Rev"},{"key":"3987_CR36","volume-title":"The rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2006","unstructured":"Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates, 6th edn. Academic Press; Cambridge, MA","edition":"6"},{"key":"3987_CR37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3389\/fninf.2011.00002","volume":"5","author":"LJ Kjonigsen","year":"2011","unstructured":"Kjonigsen LJ, Leergaard TB, Witter MP, Bjaalie JG (2011) Digital atlas of anatomical subdivisions and boundaries of the rat hippocampal region. Front Neuroinform 5:2. https:\/\/doi.org\/10.3389\/fninf.2011.00002","journal-title":"Front Neuroinform"},{"key":"3987_CR38","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1038\/nmeth.2019","volume":"9","author":"J Schindelin","year":"2012","unstructured":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A (2012) Fiji: an open-source platform for biological-image analysis. Nat Methods 9:676\u2013682. https:\/\/doi.org\/10.1038\/nmeth.2019","journal-title":"Nat Methods"},{"key":"3987_CR39","unstructured":"Labno C (2014) Two ways to count cells with ImageJ. https:\/\/www.unige.ch\/medecine\/bioimaging\/files\/3714\/1208\/5964\/CellCounting.pdf. Accessed 7 March 2022"},{"key":"3987_CR40","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.bbi.2020.05.076","volume":"89","author":"JY Goh","year":"2020","unstructured":"Goh JY, O\u2019Sullivan SE, Shortall SE, Zordan N, Piccinini AM, Potter HG, Fone KCF, King MV (2020) Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat \u201cdual-hit\u201d model for neurodevelopmental disorders. Brain Behav Immun 89:100\u2013117. https:\/\/doi.org\/10.1016\/j.bbi.2020.05.076","journal-title":"Brain Behav Immun"},{"key":"3987_CR41","doi-asserted-by":"publisher","first-page":"2098","DOI":"10.1016\/j.euroneuro.2015.08.004","volume":"25","author":"MC Cotel","year":"2015","unstructured":"Cotel MC, Lenartowicz EM, Natesan S, Modo MM, Cooper JD, Williams SC, Kapur S, Vernon AC (2015) Microglial activation in the rat brain following chronic antipsychotic treatment at clinically relevant doses. Eur Neuropsychopharmacol 25:2098\u20132107. https:\/\/doi.org\/10.1016\/j.euroneuro.2015.08.004","journal-title":"Eur Neuropsychopharmacol"},{"key":"3987_CR42","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097096","volume":"9","author":"SE Taylor","year":"2014","unstructured":"Taylor SE, Morganti-Kossmann C, Lifshitz J, Ziebell JM (2014) Rod microglia: a morphological definition. PLoS ONE 9:e97096. https:\/\/doi.org\/10.1371\/journal.pone.0097096","journal-title":"PLoS ONE"},{"key":"3987_CR43","doi-asserted-by":"publisher","first-page":"5593","DOI":"10.1038\/s41598-021-85092-x","volume":"11","author":"AC Reichelt","year":"2021","unstructured":"Reichelt AC, Lemieux CA, Princz-Lebel O, Singh A, Bussey TJ, Saksida LM (2021) Age-dependent and region-specific alteration of parvalbumin neurons, perineuronal nets and microglia in the mouse prefrontal cortex and hippocampus following obesogenic diet consumption. Sci Rep 11:5593. https:\/\/doi.org\/10.1038\/s41598-021-85092-x","journal-title":"Sci Rep"},{"key":"3987_CR44","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1093\/cercor\/bhx302","volume":"29","author":"N Espinosa","year":"2019","unstructured":"Espinosa N, Alonso A, Morales C, Espinosa P, Ch\u00e1vez AE, Fuentealba P (2019) Basal forebrain gating by somatostatin neurons drives prefrontal cortical activity. Cereb Cortex 29:42\u201353. https:\/\/doi.org\/10.1093\/cercor\/bhx302","journal-title":"Cereb Cortex"},{"key":"3987_CR45","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1177\/096368971772363","volume":"26","author":"RL Nuryyev","year":"2017","unstructured":"Nuryyev RL, Uhlendorf TL, Tierney W, Zatikyan S, Kopyov O, Kopyov A, Ochoa J, Van Trigt W, Malone CS, Cohen RW (2017) Transplantation of human neural progenitor cells reveals structural and functional improvements in the spastic Han-Wistar rat model of ataxia. Cell Transplant 26:1811\u20131821. https:\/\/doi.org\/10.1177\/096368971772363","journal-title":"Cell Transplant"},{"key":"3987_CR46","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1186\/s12974-018-1378-z","volume":"15","author":"L Blaszczyk","year":"2018","unstructured":"Blaszczyk L, Ma\u00eetre M, Lest\u00e9-Lasserre T, Clark S, Cota D, Oliet SHR, F\u00e9nelon VS (2018) Sequential alteration of microglia and astrocytes in the rat thalamus following spinal nerve ligation. J Neuroinflammation 15:349. https:\/\/doi.org\/10.1186\/s12974-018-1378-z","journal-title":"J Neuroinflammation"},{"key":"3987_CR47","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0006-8993(94)91060-X","volume":"649","author":"Y Kubota","year":"1994","unstructured":"Kubota Y, Hattori R, Yui Y (1994) Three distinct subpopulations of GABAergic neurons in rat frontal agranular cortex. Brain Res 649:159\u2013273. https:\/\/doi.org\/10.1016\/0006-8993(94)91060-X","journal-title":"Brain Res"},{"key":"3987_CR48","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/S0006-8993(96)01395-9","volume":"751","author":"T Nomura","year":"1997","unstructured":"Nomura T, Fukuda T, Aika Y, Heizmann CW, Emson PC, Kobayashi T, Kosaka T (1997) Distribution of nonprincipal neurons in the rat hippocampus, with special reference to their dorsoventral difference. Brain Res 751:64\u201380. https:\/\/doi.org\/10.1016\/S0006-8993(96)01395-9","journal-title":"Brain Res"},{"key":"3987_CR49","doi-asserted-by":"publisher","first-page":"15211","DOI":"10.1038\/s41598-019-51674-z","volume":"9","author":"K Lidster","year":"2019","unstructured":"Lidster K, Owen K, Browne WJ, Prescott MJ (2019) Cage aggression in group-housed laboratory male mice: an international data crowdsourcing project. Sci Rep 9:15211. https:\/\/doi.org\/10.1038\/s41598-019-51674-z","journal-title":"Sci Rep"},{"key":"3987_CR50","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1007\/s00702-007-0627-6","volume":"114","author":"MK Harte","year":"2007","unstructured":"Harte MK, Powell SB, Swerdlow NR, Geyer MA, Reynolds GP (2007) Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats. J Neural Transm (Vienna) 114:893\u2013898. https:\/\/doi.org\/10.1007\/s00702-007-0627-6","journal-title":"J Neural Transm (Vienna)"},{"key":"3987_CR51","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1159\/000430091","volume":"37","author":"SB Powell","year":"2015","unstructured":"Powell SB, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM (2015) Early adolescent emergence of reversal learning impairments in isolation-reared rats. Dev Neurosci 37:253\u2013262. https:\/\/doi.org\/10.1159\/000430091","journal-title":"Dev Neurosci"},{"key":"3987_CR52","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.biopsych.2009.04.033","volume":"66","author":"S Schiavone","year":"2009","unstructured":"Schiavone S, Sorce S, Dubois-Dauphin M, Jaquet V, Colaianna M, Zotti M, Cuomo V, Trabace L, Krause KH (2009) Involvement of NOX2 in the development of behavioral and pathologic alterations in isolated rats. Biol Psychiatry 66:384\u2013392. https:\/\/doi.org\/10.1016\/j.biopsych.2009.04.033","journal-title":"Biol Psychiatry"},{"key":"3987_CR53","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2021.733989","volume":"13","author":"P Klimczak","year":"2021","unstructured":"Klimczak P, Rizzo A, Castillo-G\u00f3mez E, Perez-Rando M, Gramuntell Y, Beltran M, Nacher J (2021) Parvalbumin interneurons and perineuronal nets in the hippocampus and retrosplenial cortex of adult male mice after early social isolation stress and perinatal NMDA receptor antagonist treatment. Front Synaptic Neurosci 13:733989. https:\/\/doi.org\/10.3389\/fnsyn.2021.733989","journal-title":"Front Synaptic Neurosci"},{"key":"3987_CR54","doi-asserted-by":"publisher","first-page":"1010152","DOI":"10.3389\/fnmol.2022.1010152","volume":"15","author":"X Li","year":"2022","unstructured":"Li X, Sun H, Zhu Y, Wang F, Wang X, Han L, Cui D, Luo D, Zhai Y, Zhuo L, Xu X, Yang J, Li Y (2022) Dysregulation of prefrontal parvalbumin interneurons leads to adult aggression induced by social isolation stress during adolescence. Front Mol Neurosci 15:1010152. https:\/\/doi.org\/10.3389\/fnmol.2022.1010152","journal-title":"Front Mol Neurosci"},{"key":"3987_CR55","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.neuroscience.2018.11.008","volume":"396","author":"N Todorovi\u0107","year":"2019","unstructured":"Todorovi\u0107 N, Mi\u0107i\u0107 B, Schwirtlich M, Stevanovi\u0107 M, Filipovi\u0107 D (2019) Subregion-specific protective effects of fluoxetine and clozapine on parvalbumin expression in medial prefrontal cortex of chronically isolated rats. Neuroscience 396:24\u201335. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.11.008","journal-title":"Neuroscience"},{"key":"3987_CR56","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.neuroscience.2017.07.016","volume":"359","author":"H Ueno","year":"2017","unstructured":"Ueno H, Suemitsu S, Murakami S, Kitamura N, Wani K, Okamoto M, Matsumoto Y, Ishihara T (2017) Region-specific impairments in parvalbumin interneurons in social isolation-reared mice. Neuroscience 359:196\u2013208. https:\/\/doi.org\/10.1016\/j.neuroscience.2017.07.016","journal-title":"Neuroscience"},{"key":"3987_CR57","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.brainresbull.2021.05.021","volume":"173","author":"I Peri\u0107","year":"2021","unstructured":"Peri\u0107 I, Stanisavljevi\u0107 A, Gass P, Filipovi\u0107 D (2021) Fluoxetine exerts subregion\/layer specific effects on parvalbumin\/GAD67 protein expression in the dorsal hippocampus of male rats showing social isolation-induced depressive-like behaviour. Brain Res Bull 173:174\u2013183. https:\/\/doi.org\/10.1016\/j.brainresbull.2021.05.021","journal-title":"Brain Res Bull"},{"key":"3987_CR58","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1111\/jnc.12061","volume":"124","author":"SS Kaalund","year":"2013","unstructured":"Kaalund SS, Riise J, Broberg BV, Fabricius K, Karlsen AS, Secher T, Plath N, Pakkenberg B (2013) Differential expression of parvalbumin in neonatal phencyclidine-treated rats and socially isolated rats. J Neurochem 124:548\u2013557. https:\/\/doi.org\/10.1111\/jnc.12061","journal-title":"J Neurochem"},{"key":"3987_CR59","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1080\/00207450600773459","volume":"117","author":"R Pascual","year":"2007","unstructured":"Pascual R, Zamora-Le\u00f3n P, Catal\u00e1n-Ahumada M, Valero-Cabr\u00e9 A (2007) Early social isolation decreases the expression of calbindin D-28k and dendritic branching in the medial prefrontal cortex of the rat. Int J Neurosci 117:465\u2013476. https:\/\/doi.org\/10.1080\/00207450600773459","journal-title":"Int J Neurosci"},{"key":"3987_CR60","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.ijdevneu.2012.12.001","volume":"31","author":"R Pascual","year":"2013","unstructured":"Pascual R, Zamora-Le\u00f3n P, Bustamante C (2013) Selegiline (deprenyl) decreases calbindin-D28k expression in cortical neurons of rats socially deprived during the post-weaning period. Int J Dev Neurosci 31:145\u2013149. https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.12.001","journal-title":"Int J Dev Neurosci"},{"key":"3987_CR61","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/j.bbi.2017.10.024","volume":"68","author":"F Dunphy-Doherty","year":"2018","unstructured":"Dunphy-Doherty F, O\u2019Mahony SM, Peterson VL, O\u2019Sullivan O, Crispie F, Cotter PD, Wigmore P, King MV, Cryan JF, Fone KCF (2018) Post-weaning social isolation of rats leads to long-term disruption of the gut microbiota-immune-brain axis. Brain Behav Immun 68:261\u2013273. https:\/\/doi.org\/10.1016\/j.bbi.2017.10.024","journal-title":"Brain Behav Immun"},{"key":"3987_CR62","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00406-017-0807-9","volume":"267","author":"I Peri\u0107","year":"2017","unstructured":"Peri\u0107 I, Stanisavljevi\u0107 A, Gass P, Filipovi\u0107 D (2017) Fluoxetine reverses behavior changes in socially isolated rats: role of the hippocampal GSH-dependent defense system and proinflammatory cytokines. Eur Arch Psychiatry Clin Neurosci 267:737\u2013749. https:\/\/doi.org\/10.1007\/s00406-017-0807-9","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"3987_CR63","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3389\/fnins.2018.01011","volume":"12","author":"F Corsi-Zuelli","year":"2019","unstructured":"Corsi-Zuelli F, Fachim HA, Loureiro CM, Shuhama R, Bertozi G, Joca SRL, Menezes PR, Louzada-Junior P, Del-Ben CM (2019) Prolonged periods of social isolation from weaning reduce the anti-inflammatory cytokine IL-10 in blood and brain. Front Neurosci 12:1011. https:\/\/doi.org\/10.3389\/fnins.2018.01011","journal-title":"Front Neurosci"},{"key":"3987_CR64","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0091-3057(02)00794-3","volume":"73","author":"BA Ellenbroek","year":"2002","unstructured":"Ellenbroek BA, Cools AR (2002) Early maternal deprivation and prepulse inhibition: the role of the postdeprivation environment. Pharmacol Biochem Behav 73:177\u2013184. https:\/\/doi.org\/10.1016\/S0091-3057(02)00794-3","journal-title":"Pharmacol Biochem Behav"},{"key":"3987_CR65","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ijdevneu.2016.03.001","volume":"50","author":"DM Arcego","year":"2016","unstructured":"Arcego DM, Krolow R, Lampert C, Toniazzo AP, Berlitz C, Lazzaretti C, Schmitz F, Rodrigues AF, Wyse AT, Dalmaz C (2016) Early life adversities or high fat diet intake reduce cognitive function and alter BDNF signaling in adult rats: interplay of these factors changes these effects. Int J Dev Neurosci 50:16\u201325. https:\/\/doi.org\/10.1016\/j.ijdevneu.2016.03.001","journal-title":"Int J Dev Neurosci"},{"key":"3987_CR66","doi-asserted-by":"publisher","unstructured":"Castillo-G\u00f3mez E, P\u00e9rez-Rando M, Bell\u00e9s M, Gilabert-Juan J, Llorens JV, Carceller H, Bueno-Fern\u00e1ndez C, Garc\u00eda-Momp\u00f3 C, Ripoll-Mart\u00ednez B, Curto Y, Sebasti\u00e1-Ortega N, Molt\u00f3 MD, Sanjuan J, Nacher J (2017) Early social isolation stress and perinatal NMDA receptor antagonist treatment induce changes in the structure and neurochemistry of inhibitory neurons of the adult amygdala and prefrontal cortex. eNeuro 4:ENEURO.0034\u201317.2017. https:\/\/doi.org\/10.1523\/ENEURO.0034-17.2017","DOI":"10.1523\/ENEURO.0034-17.2017"},{"key":"3987_CR67","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1176\/appi.ajp.158.9.1411","volume":"158","author":"DA Lewis","year":"2001","unstructured":"Lewis DA, Cruz DA, Melchitzky DS, Pierri JN (2001) Lamina-specific deficits in parvalbumin-immunoreactive varicosities in the prefrontal cortex of subjects with schizophrenia: evidence for fewer projections from the thalamus. Am J Psychiatry 158:1411\u20131422. https:\/\/doi.org\/10.1176\/appi.ajp.158.9.1411","journal-title":"Am J Psychiatry"},{"key":"3987_CR68","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1007\/s00702-019-02080-2","volume":"126","author":"SJ Kaar","year":"2019","unstructured":"Kaar SJ, Angelescu I, Marques TR, Howes OD (2019) Pre-frontal parvalbumin interneurons in schizophrenia: a meta-analysis of post-mortem studies. J Neural Transm (Vienna) 126:1637\u20131651. https:\/\/doi.org\/10.1007\/s00702-019-02080-2","journal-title":"J Neural Transm (Vienna)"},{"key":"3987_CR69","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.bbr.2003.09.028","volume":"146","author":"HB Uylings","year":"2003","unstructured":"Uylings HB, Groenewegen HJ, Kolb B (2003) Do rats have a prefrontal cortex? Behav Brain Res 146:3\u201317. https:\/\/doi.org\/10.1016\/j.bbr.2003.09.028","journal-title":"Behav Brain Res"},{"key":"3987_CR70","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1038\/sj.mp.4001471","volume":"9","author":"Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF; Stanley Neuropathology Consortium","year":"2004","unstructured":"Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey EF; Stanley Neuropathology Consortium (2004) Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 9:609\u2013620. https:\/\/doi.org\/10.1038\/sj.mp.4001471","journal-title":"Mol Psychiatry"},{"key":"3987_CR71","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3389\/fncel.2016.00078","volume":"10","author":"P Falkai","year":"2016","unstructured":"Falkai P, Steiner J, Malchow B, Shariati J, Knaus A, Bernstein HG, Schneider-Axmann T, Kraus T, Hasan A, Bogerts B, Schmitt A (2016) Oligodendrocyte and interneuron density in hippocampal subfields in schizophrenia and association of oligodendrocyte number with cognitive deficits. Front Cell Neurosci 10:78. https:\/\/doi.org\/10.3389\/fncel.2016.00078","journal-title":"Front Cell Neurosci"},{"key":"3987_CR72","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1176\/ajp.154.7.1013","volume":"154","author":"TU Woo","year":"1997","unstructured":"Woo TU, Miller JL, Lewis DA (1997) Schizophrenia and the parvalbumin-containing class of cortical local circuit neurons. Am J Psychiatry 154:1013\u20131015. https:\/\/doi.org\/10.1176\/ajp.154.7.1013","journal-title":"Am J Psychiatry"},{"key":"3987_CR73","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.pnpbp.2003.10.004","volume":"28","author":"PA Tooney","year":"2004","unstructured":"Tooney PA, Chahl LA (2004) Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 28:273\u2013278. https:\/\/doi.org\/10.1016\/j.pnpbp.2003.10.004","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"3987_CR74","doi-asserted-by":"publisher","first-page":"2501","DOI":"10.1017\/S0033291716001446","volume":"46","author":"DW Volk","year":"2016","unstructured":"Volk DW, Sampson AR, Zhang Y, Edelson JR, Lewis DA (2016) Cortical GABA markers identify a molecular subtype of psychotic and bipolar disorders. Psychol Med 46:2501\u20132512. https:\/\/doi.org\/10.1017\/S0033291716001446","journal-title":"Psychol Med"},{"key":"3987_CR75","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/j.schres.2018.02.048","volume":"199","author":"DR Goldsmith","year":"2018","unstructured":"Goldsmith DR, Haroon E, Miller AH, Strauss GP, Buckley PF, Miller BJ (2018) TNF-\u03b1 and IL-6 are associated with the deficit syndrome and negative symptoms in patients with chronic schizophrenia. Schizophr Res 199:281\u2013284. https:\/\/doi.org\/10.1016\/j.schres.2018.02.048","journal-title":"Schizophr Res"},{"key":"3987_CR76","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.958972","volume":"13","author":"D Wang","year":"2023","unstructured":"Wang D, Wang Y, Chen Y, Yu L, Wu Z, Liu R, Ren J, Fang X, Zhang C (2023) Differences in inflammatory marker profiles and cognitive functioning between deficit and nondeficit schizophrenia. Front Immunol 13:958972. https:\/\/doi.org\/10.3389\/fimmu.2022.958972","journal-title":"Front Immunol"},{"key":"3987_CR77","doi-asserted-by":"publisher","first-page":"996","DOI":"10.1001\/archpsyc.1991.01810350036005","volume":"48","author":"FM Benes","year":"1991","unstructured":"Benes FM, McSparren J, Bird ED, SanGiovanni JP, Vincent SL (1991) Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients. Arch Gen Psychiatry 48:996\u20131001. https:\/\/doi.org\/10.1001\/archpsyc.1991.01810350036005","journal-title":"Arch Gen Psychiatry"},{"key":"3987_CR78","doi-asserted-by":"publisher","unstructured":"Gaus R, Popal M, Heinsen H, Schmitt A, Falkai P, Hof PR, Schmitz C, Vollhardt A (2022) Reduced cortical neuron number and neuron density in schizophrenia with focus on area 24: a post-mortem case-control study. Eur Arch Psychiatry Clin Neurosci. https:\/\/doi.org\/10.1007\/s00406-022-01513-6","DOI":"10.1007\/s00406-022-01513-6"},{"key":"3987_CR79","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/S0022-3956(00)00043-1","volume":"35","author":"JJ Thune","year":"2001","unstructured":"Thune JJ, Uylings HB, Pakkenberg B (2001) No deficit in total number of neurons in the prefrontal cortex in schizophrenics. J Psychiatr Res 35:15\u201321. https:\/\/doi.org\/10.1016\/S0022-3956(00)00043-1","journal-title":"J Psychiatr Res"},{"key":"3987_CR80","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1176\/appi.ajp.161.5.882","volume":"161","author":"AK Stark","year":"2004","unstructured":"Stark AK, Uylings HB, Sanz-Arigita E, Pakkenberg B (2004) Glial cell loss in the anterior cingulate cortex, a subregion of the prefrontal cortex, in subjects with schizophrenia. Am J Psychiatry 161:882\u2013888. https:\/\/doi.org\/10.1176\/appi.ajp.161.5.882","journal-title":"Am J Psychiatry"},{"key":"3987_CR81","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1001\/archpsyc.1995.03950160008002","volume":"52","author":"S Akbarian","year":"1995","unstructured":"Akbarian S, Kim JJ, Potkin SG, Hagman JO, Tafazzoli A, Bunney WE Jr, Jones EG (1995) Gene expression for glutamic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Arch Gen Psychiatry 52:258\u2013266. https:\/\/doi.org\/10.1001\/archpsyc.1995.03950160008002","journal-title":"Arch Gen Psychiatry"},{"key":"3987_CR82","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/sj.mp.4002011","volume":"13","author":"T Hashimoto","year":"2008","unstructured":"Hashimoto T, Arion D, Unger T, Maldonado-Avil\u00e9s JG, Morris HM, Volk DW, Mirnics K, Lewis DA (2008) Alterations in GABA-related transcriptome in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry 13:147\u2013161. https:\/\/doi.org\/10.1038\/sj.mp.4002011","journal-title":"Mol Psychiatry"},{"key":"3987_CR83","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1016\/j.brainres.2008.03.092","volume":"1218","author":"TU Woo","year":"2008","unstructured":"Woo TU, Kim AM, Viscidi E (2008) Disease-specific alterations in glutamatergic neurotransmission on inhibitory interneurons in the prefrontal cortex in schizophrenia. Brain Res 1218:267\u2013277. https:\/\/doi.org\/10.1016\/j.brainres.2008.03.092","journal-title":"Brain Res"},{"key":"3987_CR84","doi-asserted-by":"publisher","first-page":"970","DOI":"10.1016\/j.jpsychires.2009.02.005","volume":"43","author":"M Thompson","year":"2009","unstructured":"Thompson M, Weickert CS, Wyatt E, Webster MJ (2009) Decreased glutamic acid decarboxylase(67) mRNA expression in multiple brain areas of patients with schizophrenia and mood disorders. J Psychiatr Res 43:970\u2013977. https:\/\/doi.org\/10.1016\/j.jpsychires.2009.02.005","journal-title":"J Psychiatr Res"},{"key":"3987_CR85","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.biopsych.2010.09.036","volume":"69","author":"SJ Fung","year":"2011","unstructured":"Fung SJ, Sivagnanasundaram S, Weickert CS (2011) Lack of change in markers of presynaptic terminal abundance alongside subtle reductions in markers of presynaptic terminal plasticity in prefrontal cortex of schizophrenia patients. Biol Psychiatry 69:71\u201379. https:\/\/doi.org\/10.1016\/j.biopsych.2010.09.036","journal-title":"Biol Psychiatry"},{"key":"3987_CR86","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1016\/j.biopsych.2015.07.022","volume":"79","author":"BR Rocco","year":"2016","unstructured":"Rocco BR, Lewis DA, Fish KN (2016) Markedly lower glutamic acid decarboxylase 67 protein levels in a subset of boutons in schizophrenia. Biol Psychiatry 79:1006\u20131015. https:\/\/doi.org\/10.1016\/j.biopsych.2015.07.022","journal-title":"Biol Psychiatry"},{"key":"3987_CR87","doi-asserted-by":"publisher","unstructured":"Dienel SJ, Fish KN, Lewis DA (2023) The nature of prefrontal cortical GABA neuron alterations in schizophrenia: markedly lower somatostatin and parvalbumin gene expression without missing neurons. Am J Psychiatry.\u00a0https:\/\/doi.org\/10.1176\/appi.ajp.20220676","DOI":"10.1176\/appi.ajp.20220676"},{"key":"3987_CR88","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.biopsych.2022.08.004","volume":"93","author":"M Simmonite","year":"2023","unstructured":"Simmonite M, Steeby CJ, Taylor SF (2023) Medial frontal cortex GABA concentrations in psychosis spectrum and mood disorders: a meta-analysis of proton magnetic resonance spectroscopy studies. Biol Psychiatry 93:125\u2013136. https:\/\/doi.org\/10.1016\/j.biopsych.2022.08.004","journal-title":"Biol Psychiatry"},{"key":"3987_CR89","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/s0920-9964(01)00299-7","volume":"57","author":"DW Eyles","year":"2002","unstructured":"Eyles DW, McGrath JJ, Reynolds GP (2002) Neuronal calcium-binding proteins and schizophrenia. Schizophr Res 57:27\u201334. https:\/\/doi.org\/10.1016\/s0920-9964(01)00299-7","journal-title":"Schizophr Res"},{"key":"3987_CR90","doi-asserted-by":"publisher","first-page":"105","DOI":"10.3389\/fncel.2020.00105","volume":"14","author":"K Yamamuro","year":"2020","unstructured":"Yamamuro K, Yoshino H, Ogawa Y, Okamura K, Nishihata Y, Makinodan M, Saito Y, Kishimoto T (2020) Juvenile social isolation enhances the activity of inhibitory neuronal circuits in the medial prefrontal cortex. Front Cell Neurosci 14:105. https:\/\/doi.org\/10.3389\/fncel.2020.00105","journal-title":"Front Cell Neurosci"},{"key":"3987_CR91","doi-asserted-by":"publisher","first-page":"3591","DOI":"10.1093\/cercor\/bhac294","volume":"33","author":"K Okamura","year":"2023","unstructured":"Okamura K, Yoshino H, Ogawa Y, Yamamuro K, Kimoto S, Yamaguchi Y, Nishihata Y, Ikehara M, Makinodan M, Saito Y, Kishimoto T (2023) Juvenile social isolation immediately affects the synaptic activity and firing property of fast-spiking parvalbumin-expressing interneuron subtype in mouse medial prefrontal cortex. Cereb Cortex 33:3591\u20133606. https:\/\/doi.org\/10.1093\/cercor\/bhac294","journal-title":"Cereb Cortex"},{"key":"3987_CR92","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1007\/s13365-016-0447-2","volume":"22","author":"WD Marks","year":"2016","unstructured":"Marks WD, Paris JJ, Schier CJ, Denton MD, Fitting S, McQuiston AR, Knapp PE, Hauser KF (2016) HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations. J Neurovirol 22:747\u2013762. https:\/\/doi.org\/10.1007\/s13365-016-0447-2","journal-title":"J Neurovirol"},{"key":"3987_CR93","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3389\/fncir.2018.00037","volume":"12","author":"BR Ferguson","year":"2018","unstructured":"Ferguson BR, Gao WJ (2018) PV interneurons: critical regulators of E\/I balance for prefrontal cortex-dependent behavior and psychiatric disorders. Front Neural Circuits 12:37. https:\/\/doi.org\/10.3389\/fncir.2018.00037","journal-title":"Front Neural Circuits"},{"key":"3987_CR94","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1093\/cercor\/6.2.311","volume":"6","author":"RP Kesner","year":"1996","unstructured":"Kesner RP, Hunt ME, Williams JM, Long JM (1996) Prefrontal cortex and working memory for spatial response, spatial location, and visual object information in the rat. Cereb Cortex 6:311\u2013318. https:\/\/doi.org\/10.1093\/cercor\/6.2.311","journal-title":"Cereb Cortex"},{"key":"3987_CR95","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2021.107544","volume":"186","author":"AB de Landeta","year":"2021","unstructured":"de Landeta AB, Pereyra M, Miranda M, Bekinschtein P, Medina JH, Katche C (2021) Functional connectivity of anterior retrosplenial cortex in object recognition memory. Neurobiol Learn Mem 186:107544. https:\/\/doi.org\/10.1016\/j.nlm.2021.107544","journal-title":"Neurobiol Learn Mem"},{"key":"3987_CR96","doi-asserted-by":"publisher","first-page":"16778","DOI":"10.1038\/srep16778","volume":"5","author":"AJ Murray","year":"2015","unstructured":"Murray AJ, Woloszynowska-Fraser MU, Ansel-Bollepalli L, Cole KL, Foggetti A, Crouch B, Riedel G, Wulff P (2015) Parvalbumin-positive interneurons of the prefrontal cortex support working memory and cognitive flexibility. Sci Rep 5:16778. https:\/\/doi.org\/10.1038\/srep16778","journal-title":"Sci Rep"},{"key":"3987_CR97","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1038\/s41398-019-0603-6","volume":"9","author":"SM Perez","year":"2019","unstructured":"Perez SM, Boley A, Lodge DJ (2019) Region specific knockdown of parvalbumin or somatostatin produces neuronal and behavioral deficits consistent with those observed in schizophrenia. Transl Psychiatry 9:264. https:\/\/doi.org\/10.1038\/s41398-019-0603-6","journal-title":"Transl Psychiatry"},{"key":"3987_CR98","doi-asserted-by":"publisher","first-page":"926","DOI":"10.1016\/j.neuron.2018.09.029","volume":"100","author":"AI Abbas","year":"2018","unstructured":"Abbas AI, Sundiang MJM, Henoch B, Morton MP, Bolkan SS, Park AJ, Harris AZ, Kellendonk C, Gordon JA (2018) Somatostatin interneurons facilitate hippocampal-prefrontal synchrony and prefrontal spatial encoding. Neuron 100:926\u2013939. https:\/\/doi.org\/10.1016\/j.neuron.2018.09.029","journal-title":"Neuron"},{"key":"3987_CR99","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1093\/schbul\/sbz123","volume":"46","author":"O Toader","year":"2020","unstructured":"Toader O, von Heimendahl M, Schuelert N, Nissen W, Rosenbrock H (2020) Suppression of parvalbumin interneuron activity in the prefrontal cortex recapitulates features of impaired excitatory\/inhibitory balance and sensory processing in schizophrenia. Schizophr Bull 46:981\u2013989. https:\/\/doi.org\/10.1093\/schbul\/sbz123","journal-title":"Schizophr Bull"},{"key":"3987_CR100","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.schres.2022.12.047","volume":"252","author":"E Patrono","year":"2023","unstructured":"Patrono E, Hr\u016fzova K, Svoboda J, Stuchl\u00edk A (2023) The role of optogenetic stimulations of parvalbumin-positive interneurons in the prefrontal cortex and the ventral hippocampus on an acute MK-801 model of schizophrenia-like cognitive inflexibility. Schizophr Res 252:198\u2013205. https:\/\/doi.org\/10.1016\/j.schres.2022.12.047","journal-title":"Schizophr Res"},{"key":"3987_CR101","doi-asserted-by":"publisher","unstructured":"Chamberlin LA, Yang SS, McEachern EP, Lucas JTM, McLeod Ii OW, Rolland CA, Mack NR, Ferguson BR, Gao WJ (2023) Pharmacogenetic activation of parvalbumin interneurons in the prefrontal cortex rescues cognitive deficits induced by adolescent MK801 administration. Neuropsychopharmacology.\u00a0\u00a0https:\/\/doi.org\/10.1038\/s41386-023-01576-6","DOI":"10.1038\/s41386-023-01576-6"},{"key":"3987_CR102","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.bbi.2021.08.216","volume":"98","author":"XY Feng","year":"2021","unstructured":"Feng XY, Hu HD, Chen J, Long C, Yang L, Wang L (2021) Acute neuroinflammation increases excitability of prefrontal parvalbumin interneurons and their functional recruitment during novel object recognition. Brain Behav Immun 98:48\u201358. https:\/\/doi.org\/10.1016\/j.bbi.2021.08.216","journal-title":"Brain Behav Immun"},{"key":"3987_CR103","doi-asserted-by":"publisher","first-page":"E82","DOI":"10.1093\/ilar.53.1.82","volume":"53","author":"JW Arts","year":"2012","unstructured":"Arts JW, Kramer K, Arndt SS, Ohl F (2012) The impact of transportation on physiological and behavioral parameters in Wistar rats: implications for acclimatization periods. ILAR J 53:E82\u2013E98. https:\/\/doi.org\/10.1093\/ilar.53.1.82","journal-title":"ILAR J"},{"key":"3987_CR104","doi-asserted-by":"publisher","unstructured":"Giordano GM, Bucci P, Mucci A, Pezzella P, Galderisi S (2021) Gender differences in clinical and psychosocial features among persons with schizophrenia: a mini review. Front Psychiatry 12:789179. https:\/\/doi.org\/10.3389\/fpsyt.2021.789179","DOI":"10.3389\/fpsyt.2021.789179"},{"key":"3987_CR105","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1177\/0269881108093842","volume":"24","author":"S McLean","year":"2010","unstructured":"McLean S, Grayson B, Harris M, Protheroe C, Woolley M, Neill J (2010) Isolation rearing impairs novel object recognition and attentional set shifting performance in female rats. J Psychopharmacol 24:57\u201363. https:\/\/doi.org\/10.1177\/0269881108093842","journal-title":"J Psychopharmacol"},{"key":"3987_CR106","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.ibneur.2023.05.010","volume":"15","author":"GO Ayilara","year":"2023","unstructured":"Ayilara GO, Owoyele BV (2023) Neuroinflammation and microglial expression in brains of social-isolation rearing model of schizophrenia. IBRO Neurosci Rep 15:31\u201341. https:\/\/doi.org\/10.1016\/j.ibneur.2023.05.010","journal-title":"IBRO Neurosci Rep"},{"key":"3987_CR107","doi-asserted-by":"publisher","first-page":"836","DOI":"10.3390\/brainsci13050836","volume":"13","author":"EA Ermakov","year":"2023","unstructured":"Ermakov EA, Melamud MM, Boiko AS, Kamaeva DA, Ivanova SA, Nevinsky GA, Buneva VN (2023) Association of peripheral inflammatory biomarkers and growth factors levels with sex, therapy and other clinical factors in schizophrenia and patient stratification based on these data. Brain Sci 13:836. https:\/\/doi.org\/10.3390\/brainsci13050836","journal-title":"Brain Sci"},{"key":"3987_CR108","doi-asserted-by":"publisher","unstructured":"DuMont M, Agostinis A, Singh K, Swan E, Buttle Y, Tropea D (2023) Sex representation in neurodegenerative and psychiatric disorders' preclinical and clinical studies. Neurobiol Dis 184:106214. https:\/\/doi.org\/10.1016\/j.nbd.2023.106214","DOI":"10.1016\/j.nbd.2023.106214"},{"key":"3987_CR109","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00213-020-05700-y","volume":"238","author":"AM Hamieh","year":"2021","unstructured":"Hamieh AM, Babin D, Sabl\u00e9 E, Hernier AM, Castagn\u00e9 V (2021) Neonatal phencyclidine and social isolation in the rat: effects of clozapine on locomotor activity, social recognition, prepulse inhibition, and executive functions deficits. Psychopharmacology 238:517\u2013528. https:\/\/doi.org\/10.1007\/s00213-020-05700-y","journal-title":"Psychopharmacology"},{"key":"3987_CR110","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1007\/s00228-018-2498-1","volume":"74","author":"ELA Ribeiro","year":"2018","unstructured":"Ribeiro ELA, de Mendon\u00e7a LT, Vieira MEB, Storpirtis S, Aguiar PM (2018) Efficacy and safety of aripiprazole for the treatment of schizophrenia: an overview of systematic reviews. Eur J Clin Pharmacol 74:1215\u20131233. https:\/\/doi.org\/10.1007\/s00228-018-2498-1","journal-title":"Eur J Clin Pharmacol"},{"key":"3987_CR111","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.euroneuro.2018.10.008","volume":"29","author":"S Marder","year":"2019","unstructured":"Marder S, Fleischhacker WW, Earley W, Lu K, Zhong Y, N\u00e9meth G, Laszlovszky I, Szalai E, Durgam S (2019) Efficacy of cariprazine across symptom domains in patients with acute exacerbation of schizophrenia: pooled analyses from 3 phase II\/III studies. Eur Neuropsychopharmacol 29:127\u2013136. https:\/\/doi.org\/10.1016\/j.euroneuro.2018.10.008","journal-title":"Eur Neuropsychopharmacol"},{"key":"3987_CR112","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1111\/acps.13498","volume":"147","author":"A Puranen","year":"2023","unstructured":"Puranen A, Koponen M, L\u00e4hteenvuo M, Tanskanen A, Tiihonen J, Taipale H (2023) Real-world effectiveness of mood stabilizer use in schizophrenia. Acta Psychiatr Scand 147:257\u2013266. https:\/\/doi.org\/10.1111\/acps.13498","journal-title":"Acta Psychiatr Scand"},{"key":"3987_CR113","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1097\/JCP.0000000000000673","volume":"37","author":"M Morozova","year":"2017","unstructured":"Morozova M, Burminskiy D, Rupchev G, Lepilkina T, Potanin S, Beniashvili A, Lavrovsky Y, Vostokova N, Ivaschenko A (2017) 5-HT6 receptor antagonist as an adjunct treatment targeting residual symptoms in patients with schizophrenia: unexpected sex-related effects (double-blind placebo-controlled trial). J Clin Psychopharmacol 37:169\u2013175. https:\/\/doi.org\/10.1097\/JCP.0000000000000673","journal-title":"J Clin Psychopharmacol"},{"key":"3987_CR114","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1016\/j.bbi.2020.08.028","volume":"90","author":"R Jeppesen","year":"2020","unstructured":"Jeppesen R, Christensen RHB, Pedersen EMJ, Nordentoft M, Hjorth\u00f8j C, K\u00f6hler-Forsberg O, Benros ME (2020) Efficacy and safety of anti-inflammatory agents in treatment of psychotic disorders - a comprehensive systematic review and meta-analysis. Brain Behav Immun 90:364\u2013380. https:\/\/doi.org\/10.1016\/j.bbi.2020.08.028","journal-title":"Brain Behav Immun"},{"key":"3987_CR115","doi-asserted-by":"publisher","first-page":"5250","DOI":"10.3390\/ijms24065250","volume":"24","author":"B Panizzutti","year":"2023","unstructured":"Panizzutti B, Skvarc D, Lin S, Croce S, Meehan A, Bortolasci CC, Marx W, Walker AJ, Hasebe K, Kavanagh BE, Morris MJ, Mohebbi M, Turner A, Gray L, Berk L, Walder K, Berk M, Dean OM (2023) Minocycline as treatment for psychiatric and neurological conditions: a systematic review and meta-analysis. Int J Mol Sci 24:5250. https:\/\/doi.org\/10.3390\/ijms24065250","journal-title":"Int J Mol Sci"},{"key":"3987_CR116","doi-asserted-by":"publisher","first-page":"S480","DOI":"10.1016\/S0924-977X(15)30653-2","volume":"25","author":"M Leger","year":"2015","unstructured":"Leger M, Alvaro G, Large C, Harte M, Neill J (2015) AUT6, a novel Kv3 channel modulator, reverses cognitive and neurobiological dysfunction in a rat model of relevance to schizophrenia symptomatology. Eur Neuropsychopharmacol 25:S480. https:\/\/doi.org\/10.1016\/S0924-977X(15)30653-2","journal-title":"Eur Neuropsychopharmacol"},{"key":"3987_CR117","doi-asserted-by":"publisher","unstructured":"Kaar SJ, Nottage JF, Angelescu I, Marques TR, Howes OD (2023) Gamma oscillations and potassium channel modulation in schizophrenia: targeting GABAergic dysfunction. Clin EEG Neurosci. https:\/\/doi.org\/10.1177\/15500594221148643","DOI":"10.1177\/15500594221148643"},{"key":"3987_CR118","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.neuroscience.2022.06.027","volume":"496","author":"HJ Chen-Engerer","year":"2022","unstructured":"Chen-Engerer HJ, Jaeger S, Bondarenko R, Sprengel R, Hengerer B, Rosenbrock H, Mack V, Schuelert N (2022) Increasing the excitatory drive rescues excitatory\/inhibitory imbalance and mismatch negativity deficit caused by parvalbumin specific GluA1 deletion. Neuroscience 496:190\u2013204. https:\/\/doi.org\/10.1016\/j.neuroscience.2022.06.027","journal-title":"Neuroscience"},{"key":"3987_CR119","doi-asserted-by":"publisher","unstructured":"Rosenbrock H, Desch M, Wunderlich G (2023) Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia. Eur Arch Psychiatry Clin Neurosci. https:\/\/doi.org\/10.1007\/s00406-023-01576-z","DOI":"10.1007\/s00406-023-01576-z"},{"key":"3987_CR120","doi-asserted-by":"publisher","first-page":"316","DOI":"10.3389\/fnmol.2018.00316","volume":"11","author":"P Cie\u015blik","year":"2018","unstructured":"Cie\u015blik P, Wo\u017aniak M, Kaczorowska K, Bra\u0144ski P, Burnat G, Chocyk A, Bobula B, Gruca P, Litwa E, Pa\u0142ucha-Poniewiera A, W\u0105sik A, Pilc A, Wiero\u0144ska J (2018) Negative allosteric modulators of mGlu7 receptor as putative antipsychotic drugs. Front Mol Neurosci 11:316. https:\/\/doi.org\/10.3389\/fnmol.2018.00316","journal-title":"Front Mol Neurosci"},{"key":"3987_CR121","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.3390\/ijms24031981","volume":"24","author":"K Kaczorowska","year":"2023","unstructured":"Kaczorowska K, Stankiewicz A, Bugno R, Paluchowska MH, Burnat G, Bra\u0144ski P, Cie\u015blik P, Wiero\u0144ska JM, Milik M, Nowak M, Przyby\u0142owicz A, Kozio\u0142 A, Hogendorf A, Hogendorf AS, Kalinowska-T\u0142u\u015bcik J, Duszy\u0144ska B, Pilc A, Bojarski AJ (2023) Design and synthesis of new quinazolin-4-one derivatives with negative mGlu7 receptor modulation activity and antipsychotic-like properties. Int J Mol Sci 24:1981. https:\/\/doi.org\/10.3390\/ijms24031981","journal-title":"Int J Mol Sci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03987-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-03987-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-03987-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T09:19:04Z","timestamp":1724404744000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-03987-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,16]]},"references-count":121,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["3987"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-03987-y","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,16]]},"assertion":[{"value":"30 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All procedures were conducted in accordance with the Animals (Scientific\u00a0Procedures) Act, 1986, with approval from the University of Nottingham Animal Welfare and Ethical Review Body (AWERB).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Not applicable, as this research did not involve human subjects.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable, as this research did not involve human subjects.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}