{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:32:54Z","timestamp":1772119974729,"version":"3.50.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T00:00:00Z","timestamp":1708300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971007"],"award-info":[{"award-number":["81971007"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Science Foundation of Hebei Province and Precision Medicine Joint Fund","award":["H2021206021"],"award-info":[{"award-number":["H2021206021"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1007\/s12035-024-04037-3","type":"journal-article","created":{"date-parts":[[2024,2,19]],"date-time":"2024-02-19T17:02:30Z","timestamp":1708362150000},"page":"7181-7194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Ceftriaxone Modulates Ubiquitination of \u03b1-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionic Acid Receptors to Improve Long-Term Potentiation Impairment Induced by Exogenous \u03b2-Amyloid in a Glutamate Transporter-1 Dependent Manner"],"prefix":"10.1007","volume":"61","author":[{"given":"Rui","family":"Jiang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizhe","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Xian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,19]]},"reference":[{"key":"4037_CR1","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1038\/nature02621","volume":"430","author":"MP Mattson","year":"2004","unstructured":"Mattson MP (2004) Pathways towards and away from Alzheimer\u2019s disease. Nature 430:631\u2013639. https:\/\/doi.org\/10.1038\/nature02621","journal-title":"Nature"},{"key":"4037_CR2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","volume":"297","author":"J Hardy","year":"2002","unstructured":"Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics. Science 297:353\u2013356. https:\/\/doi.org\/10.1126\/science.1072994","journal-title":"Science"},{"key":"4037_CR3","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","volume":"27","author":"PN Lacor","year":"2007","unstructured":"Lacor PN, Buniel MC, Furlow PW et al (2007) Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer\u2019s disease. J Neurosci 27:796\u2013807. https:\/\/doi.org\/10.1523\/JNEUROSCI.3501-06.2007","journal-title":"J Neurosci"},{"key":"4037_CR4","doi-asserted-by":"publisher","first-page":"235","DOI":"10.3389\/fnagi.2014.00235","volume":"6","author":"NN Nalivaeva","year":"2014","unstructured":"Nalivaeva NN, Belyaev ND, Kerridge C et al (2014) Amyloid-clearing proteins and their epigenetic regulation as a therapeutic target in Alzheimer\u2019s disease. Front Aging Neurosci 6:235. https:\/\/doi.org\/10.3389\/fnagi.2014.00235","journal-title":"Front Aging Neurosci"},{"key":"4037_CR5","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1126\/science.aau0043","volume":"360","author":"S Ramirez","year":"2018","unstructured":"Ramirez S (2018) Crystallizing a memory. Science 360:1182\u20131183. https:\/\/doi.org\/10.1126\/science.aau0043","journal-title":"Science"},{"key":"4037_CR6","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1006\/nbdi.1999.0278","volume":"7","author":"JC Dodart","year":"2000","unstructured":"Dodart JC, Mathis C, Saura J et al (2000) Neuroanatomical abnormalities in behaviorally characterized APP(V717F) transgenic mice. Neurobiol Dis 7:71\u201385. https:\/\/doi.org\/10.1006\/nbdi.1999.0278","journal-title":"Neurobiol Dis"},{"key":"4037_CR7","doi-asserted-by":"publisher","unstructured":"Sri S, Pegasiou C, Cave CA et al (2019) Emergence of synaptic and cognitive impairment in a mature-onset APP mouse model of Alzheimer\u2019s disease. Acta Neuropathol Commun 7. https:\/\/doi.org\/10.1186\/s40478-019-0670-1","DOI":"10.1186\/s40478-019-0670-1"},{"key":"4037_CR8","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s13024-019-0307-7","volume":"14","author":"S Chakroborty","year":"2019","unstructured":"Chakroborty S, Hill ES, Christian DT et al (2019) Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer\u2019s disease. Mol Neurodegener 14:7. https:\/\/doi.org\/10.1186\/s13024-019-0307-7","journal-title":"Mol Neurodegener"},{"key":"4037_CR9","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/nature00780","volume":"417","author":"AJ Borgdorff","year":"2002","unstructured":"Borgdorff AJ, Choquet D (2002) Regulation of AMPA receptor lateral movements. Nature 417:649\u2013653. https:\/\/doi.org\/10.1038\/nature00780","journal-title":"Nature"},{"key":"4037_CR10","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1016\/j.neuron.2007.01.030","volume":"53","author":"C Bats","year":"2007","unstructured":"Bats C, Groc L, Choquet D (2007) The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking. Neuron 53:719\u2013734. https:\/\/doi.org\/10.1016\/j.neuron.2007.01.030","journal-title":"Neuron"},{"key":"4037_CR11","doi-asserted-by":"publisher","unstructured":"Antunes G, Simoes-De-Souza FM (2018) AMPA receptor trafficking and its role in heterosynaptic plasticity. Sci Rep 8. https:\/\/doi.org\/10.1038\/s41598-018-28581-w","DOI":"10.1038\/s41598-018-28581-w"},{"key":"4037_CR12","doi-asserted-by":"publisher","first-page":"108710","DOI":"10.1016\/j.neuropharm.2021.108710","volume":"197","author":"J D\u00edaz-Alonso","year":"2021","unstructured":"D\u00edaz-Alonso J, Nicoll RA (2021) AMPA receptor trafficking and LTP: carboxy-termini, amino-termini and TARPs. Neuropharmacology 197:108710. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108710","journal-title":"Neuropharmacology"},{"key":"4037_CR13","doi-asserted-by":"publisher","first-page":"1067","DOI":"10.1111\/jnc.13194","volume":"134","author":"Y Huo","year":"2015","unstructured":"Huo Y, Khatri N, Hou Q et al (2015) The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. J Neurochem 134:1067\u20131080. https:\/\/doi.org\/10.1111\/jnc.13194","journal-title":"J Neurochem"},{"key":"4037_CR14","doi-asserted-by":"publisher","first-page":"1789","DOI":"10.3233\/JAD-170879","volume":"62","author":"Y Zhang","year":"2018","unstructured":"Zhang Y, Guo O, Huo Y et al (2018) Amyloid-\u03b2 induces AMPA receptor ubiquitination and degradation in primary neurons and human brains of Alzheimer\u2019s disease. J Alzheimer\u2019s Dis 62:1789\u20131801. https:\/\/doi.org\/10.3233\/JAD-170879","journal-title":"J Alzheimer\u2019s Dis"},{"key":"4037_CR15","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/j.1471-4159.2011.07221.x","volume":"119","author":"A Lin","year":"2011","unstructured":"Lin A, Hou Q, Jarzylo L et al (2011) Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking. J Neurochem 119:27\u201339. https:\/\/doi.org\/10.1111\/j.1471-4159.2011.07221.x","journal-title":"J Neurochem"},{"key":"4037_CR16","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3389\/fnmol.2017.00347","volume":"10","author":"J Widagdo","year":"2017","unstructured":"Widagdo J, Guntupalli S, Jang SE et al (2017) Regulation of AMPA receptor trafficking by protein ubiquitination. Front Mol Neurosci 10:347. https:\/\/doi.org\/10.3389\/fnmol.2017.00347","journal-title":"Front Mol Neurosci"},{"key":"4037_CR17","doi-asserted-by":"publisher","first-page":"948","DOI":"10.7150\/ijbs.6426","volume":"9","author":"SS Willard","year":"2013","unstructured":"Willard SS, Koochekpour S (2013) Glutamate, glutamate receptors, and downstream signaling pathways. Int J Biol Sci 9:948\u2013959. https:\/\/doi.org\/10.7150\/ijbs.6426","journal-title":"Int J Biol Sci"},{"key":"4037_CR18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/s0301-0082(00)00067-8","volume":"65","author":"NC Danbolt","year":"2001","unstructured":"Danbolt NC (2001) Glutamate uptake. Prog Neurobiol 65:1\u2013105. https:\/\/doi.org\/10.1016\/s0301-0082(00)00067-8","journal-title":"Prog Neurobiol"},{"key":"4037_CR19","doi-asserted-by":"publisher","first-page":"5671","DOI":"10.3390\/ijms20225671","volume":"20","author":"AR Malik","year":"2019","unstructured":"Malik AR, Willnow TE (2019) Excitatory amino acid transporters in physiology and disorders of the central nervous system. Int J Mol Sci 20:5671. https:\/\/doi.org\/10.3390\/ijms20225671","journal-title":"Int J Mol Sci"},{"key":"4037_CR20","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.bbr.2011.09.035","volume":"226","author":"AP Costa","year":"2012","unstructured":"Costa AP, Tramontina AC, Biasibetti R et al (2012) Neuroglial alterations in rats submitted to the okadaic acid-induced model of dementia. Behav Brain Res 226:420\u2013427. https:\/\/doi.org\/10.1016\/j.bbr.2011.09.035","journal-title":"Behav Brain Res"},{"key":"4037_CR21","doi-asserted-by":"publisher","first-page":"287","DOI":"10.3233\/JAD-2011-101005","volume":"24","author":"A Schallier","year":"2011","unstructured":"Schallier A, Smolders I, Van Dam D et al (2011) Region- and age-specific changes in glutamate transport in the AbetaPP23 mouse model for Alzheimer\u2019s disease. J Alzheimers Dis 24:287\u2013300. https:\/\/doi.org\/10.3233\/JAD-2011-101005","journal-title":"J Alzheimers Dis"},{"key":"4037_CR22","doi-asserted-by":"publisher","first-page":"2552","DOI":"10.1523\/JNEUROSCI.3237-11.2012","volume":"32","author":"LA Jarzylo","year":"2012","unstructured":"Jarzylo LA, Man HY (2012) Parasynaptic NMDA receptor signaling couples neuronal glutamate transporter function to AMPA receptor synaptic distribution and stability. J Neurosci 32:2552\u20132563. https:\/\/doi.org\/10.1523\/JNEUROSCI.3237-11.2012","journal-title":"J Neurosci"},{"key":"4037_CR23","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1016\/j.celrep.2015.01.015","volume":"10","author":"J Widagdo","year":"2015","unstructured":"Widagdo J, Chai YJ, Ridder MC et al (2015) Activity-dependent ubiquitination of GluA1 and GluA2 regulates AMPA receptor intracellular sorting and degradation. Cell Rep 10:783\u2013795. https:\/\/doi.org\/10.1016\/j.celrep.2015.01.015","journal-title":"Cell Rep"},{"key":"4037_CR24","doi-asserted-by":"publisher","first-page":"16718","DOI":"10.1523\/JNEUROSCI.3686-10.2010","volume":"30","author":"LA Schwarz","year":"2010","unstructured":"Schwarz LA, Hall BJ, Patrick GN (2010) Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway. J Neurosci 30:16718\u201316729. https:\/\/doi.org\/10.1523\/JNEUROSCI.3686-10.2010","journal-title":"J Neurosci"},{"key":"4037_CR25","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/978-3-030-38266-7_8","volume":"1233","author":"LD Harris","year":"2020","unstructured":"Harris LD, Jasem S, Licchesi J (2020) The ubiquitin system in Alzheimer\u2019s disease. Adv Exp Med Biol 1233:195\u2013221. https:\/\/doi.org\/10.1007\/978-3-030-38266-7_8","journal-title":"Adv Exp Med Biol"},{"key":"4037_CR26","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/nature03180","volume":"433","author":"JD Rothstein","year":"2005","unstructured":"Rothstein JD, Patel S, Regan MR et al (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature 433:73\u201377. https:\/\/doi.org\/10.1038\/nature03180","journal-title":"Nature"},{"key":"4037_CR27","doi-asserted-by":"publisher","first-page":"107480","DOI":"10.1016\/j.nlm.2021.107480","volume":"183","author":"S Fan","year":"2021","unstructured":"Fan S, Li L, Xian X et al (2021) Ceftriaxone regulates glutamate production and vesicular assembly in presynaptic terminals through GLT-1 in APP\/PS1 mice. Neurobiol Learn Mem 183:107480. https:\/\/doi.org\/10.1016\/j.nlm.2021.107480","journal-title":"Neurobiol Learn Mem"},{"key":"4037_CR28","doi-asserted-by":"publisher","first-page":"580772","DOI":"10.3389\/fnagi.2020.580772","volume":"12","author":"J Gao","year":"2020","unstructured":"Gao J, Liu L, Liu C et al (2020) GLT-1 knockdown inhibits ceftriaxone-mediated improvements on cognitive deficits, and GLT-1 and xCT expression and activity in APP\/PS1 AD mice. Front Aging Neurosci 12:580772. https:\/\/doi.org\/10.3389\/fnagi.2020.580772","journal-title":"Front Aging Neurosci"},{"key":"4037_CR29","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.3233\/JAD-180708","volume":"66","author":"S Fan","year":"2018","unstructured":"Fan S, Xian X, Li L et al (2018) Ceftriaxone improves cognitive function and upregulates GLT-1-related glutamate-glutamine cycle in APP\/PS1 mice. J Alzheimer\u2019s Dis 66:1731\u20131743. https:\/\/doi.org\/10.3233\/JAD-180708","journal-title":"J Alzheimer\u2019s Dis"},{"key":"4037_CR30","doi-asserted-by":"publisher","first-page":"3189","DOI":"10.1111\/bph.12955","volume":"172","author":"JC Mcgrath","year":"2015","unstructured":"Mcgrath JC, Lilley E (2015) Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Brit J Pharmacol 172:3189\u20133193. https:\/\/doi.org\/10.1111\/bph.12955","journal-title":"Brit J Pharmacol"},{"key":"4037_CR31","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1002\/1873-3468.12590","volume":"591","author":"DM Vadukul","year":"2017","unstructured":"Vadukul DM, Gbajumo O, Marshall KE et al (2017) Amyloidogenicity and toxicity of the reverse and scrambled variants of amyloid-\u03b2 1\u201342. Febs Lett 591:822\u2013830. https:\/\/doi.org\/10.1002\/1873-3468.12590","journal-title":"Febs Lett"},{"key":"4037_CR32","doi-asserted-by":"publisher","first-page":"819523","DOI":"10.3389\/fmicb.2022.819523","volume":"13","author":"Q Xu","year":"2022","unstructured":"Xu Q, Wen L, Wei G et al (2022) Marked response of rat ileal and colonic microbiota after the establishment of Alzheimer\u2019s disease model with bilateral intraventricular injection of A\u03b2 (1\u201342). Front Microbiol 13:819523. https:\/\/doi.org\/10.3389\/fmicb.2022.819523","journal-title":"Front Microbiol"},{"key":"4037_CR33","doi-asserted-by":"publisher","unstructured":"Kim HY, Lee DK, Chung BR et al (2016) Intracerebroventricular injection of Amyloid-\u03b2 peptides in normal mice to acutely induce Alzheimer-like cognitive deficits. J Vis Exp 109 https:\/\/doi.org\/10.3791\/53308","DOI":"10.3791\/53308"},{"key":"4037_CR34","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1038\/nrn.2016.37","volume":"17","author":"JM Henley","year":"2016","unstructured":"Henley JM, Wilkinson KA (2016) Synaptic AMPA receptor composition in development, plasticity and disease. Nat Rev Neurosci 17:337\u2013350. https:\/\/doi.org\/10.1038\/nrn.2016.37","journal-title":"Nat Rev Neurosci"},{"key":"4037_CR35","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2016\/3204519","volume":"2016","author":"S Guntupalli","year":"2016","unstructured":"Guntupalli S, Widagdo J, Anggono V (2016) Amyloid-\u03b2 induced dysregulation of AMPA receptor trafficking. Neural Plast 2016:1\u201312. https:\/\/doi.org\/10.1155\/2016\/3204519","journal-title":"Neural Plast"},{"key":"4037_CR36","doi-asserted-by":"publisher","first-page":"116969","DOI":"10.1016\/j.lfs.2019.116969","volume":"238","author":"N Hamidi","year":"2019","unstructured":"Hamidi N, Nozad A, Sheikhkanloui Milan H et al (2019) Effect of ceftriaxone on paired-pulse response and long-term potentiation of hippocampal dentate gyrus neurons in rats with Alzheimer-like disease. Life Sci 238:116969. https:\/\/doi.org\/10.1016\/j.lfs.2019.116969","journal-title":"Life Sci"},{"key":"4037_CR37","doi-asserted-by":"publisher","first-page":"4160","DOI":"10.3390\/molecules27134160","volume":"27","author":"Y Han","year":"2022","unstructured":"Han Y, Chen L, Liu J et al (2022) A class I HDAC inhibitor rescues synaptic damage and neuron loss in APP-transfected cells and APP\/PS1 mice through the GRIP1\/AMPA pathway. Molecules 27:4160. https:\/\/doi.org\/10.3390\/molecules27134160","journal-title":"Molecules"},{"key":"4037_CR38","doi-asserted-by":"publisher","first-page":"577996","DOI":"10.3389\/fnagi.2020.577996","volume":"12","author":"A Mart\u00edn-Belmonte","year":"2020","unstructured":"Mart\u00edn-Belmonte A, Aguado C, Alfaro-Ru\u00edz R et al (2020) Age-dependent shift of AMPA receptors from synapses to intracellular compartments in Alzheimer\u2019s disease: immunocytochemical analysis of the CA1 hippocampal region in APP\/PS1 transgenic mouse model. Front Aging Neurosci 12:577996. https:\/\/doi.org\/10.3389\/fnagi.2020.577996","journal-title":"Front Aging Neurosci"},{"key":"4037_CR39","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1038\/nm1782","volume":"14","author":"GM Shankar","year":"2008","unstructured":"Shankar GM, Li S, Mehta TH et al (2008) Amyloid-\u03b2 protein dimers isolated directly from Alzheimer\u2019s brains impair synaptic plasticity and memory. Nat Med 14:837\u2013842. https:\/\/doi.org\/10.1038\/nm1782","journal-title":"Nat Med"},{"issue":"3","key":"4037_CR40","doi-asserted-by":"publisher","first-page":"e13113","DOI":"10.1111\/acel.13113","volume":"19","author":"Y Du","year":"2020","unstructured":"Du Y, Fu M, Huang Z et al (2020) TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23\/PS45 mouse model of Alzheimer\u2019s disease. Aging Cell 19(3):e13113. https:\/\/doi.org\/10.1111\/acel.13113","journal-title":"Aging Cell"},{"key":"4037_CR41","doi-asserted-by":"publisher","first-page":"1590","DOI":"10.1523\/JNEUROSCI.2964-15.2016","volume":"36","author":"EM Rodrigues","year":"2016","unstructured":"Rodrigues EM, Scudder SL, Goo MS et al (2016) Abeta-induced synaptic alterations require the E3 ubiquitin ligase Nedd4-1. J Neurosci 36:1590\u20131595. https:\/\/doi.org\/10.1523\/JNEUROSCI.2964-15.2016","journal-title":"J Neurosci"},{"key":"4037_CR42","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.neuint.2008.07.010","volume":"53","author":"AL Sheldon","year":"2008","unstructured":"Sheldon AL, Gonz\u00e1lez MI, Krizman-Genda EN et al (2008) Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1. Neurochem Int 53:296\u2013308. https:\/\/doi.org\/10.1016\/j.neuint.2008.07.010","journal-title":"Neurochem Int"},{"key":"4037_CR43","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1016\/j.neuropharm.2016.03.042","volume":"107","author":"I Ib\u00e1\u00f1ez","year":"2016","unstructured":"Ib\u00e1\u00f1ez I, D\u00edez-Guerra FJ, Gim\u00e9nez C et al (2016) Activity dependent internalization of the glutamate transporter GLT-1 mediated by \u03b2-arrestin 1 and ubiquitination. Neuropharmacology 107:376\u2013386. https:\/\/doi.org\/10.1016\/j.neuropharm.2016.03.042","journal-title":"Neuropharmacology"},{"key":"4037_CR44","doi-asserted-by":"publisher","first-page":"1649","DOI":"10.1007\/s00726-021-03088-3","volume":"53","author":"WW Gu","year":"2021","unstructured":"Gu WW, Cui X, Liu LZ et al (2021) Sulbactam improves binding property and uptake capacity of glutamate transporter-1 and decreases glutamate concentration in the CA1 region of hippocampus of global brain ischemic rats. Amino Acids 53:1649\u20131661. https:\/\/doi.org\/10.1007\/s00726-021-03088-3","journal-title":"Amino Acids"},{"key":"4037_CR45","doi-asserted-by":"publisher","unstructured":"Postnikova TY, Malkin SL, Zakharova MV et al (2021) Ceftriaxone treatment weakens long-term synaptic potentiation in the hippocampus of young rats. Int J Mol Sci 22. https:\/\/doi.org\/10.3390\/ijms22168417","DOI":"10.3390\/ijms22168417"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04037-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04037-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04037-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T12:29:36Z","timestamp":1724329776000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04037-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,19]]},"references-count":45,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["4037"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04037-3","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-3481779\/v1","asserted-by":"object"}]},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2,19]]},"assertion":[{"value":"26 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 February 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experiments and the study protocols were approved by the Laboratory Animal Ethical and Welfare Committee of the Hebei Medical University, China (IACUC-Hebmu-2022013).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}