{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T21:34:56Z","timestamp":1789508096473,"version":"build-2803163510"},"reference-count":140,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s12035-024-04067-x","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T15:02:47Z","timestamp":1709305367000},"page":"7717-7731","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Lactate\/Hydroxycarboxylic Acid Receptor 1 in Alzheimer\u2019s Disease: Mechanisms and Therapeutic Implications-Exercise Perspective"],"prefix":"10.1007","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-5839-3156","authenticated-orcid":false,"given":"Xiangyuan","family":"Meng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzhe","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunling","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zelin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5641-3670","authenticated-orcid":false,"given":"Wenfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"4067_CR1","doi-asserted-by":"publisher","unstructured":"Breijyeh Z, Karaman R (2020) Comprehensive review on Alzheimer\u2019s disease: causes and treatment. Molecules 25(24).\u00a0https:\/\/doi.org\/10.3390\/molecules25245789","DOI":"10.3390\/molecules25245789"},{"key":"4067_CR2","doi-asserted-by":"publisher","unstructured":"(2023) 2023 Alzheimer\u2019s disease facts and figures. Alzheimers Dement 19(4):1598-1695.\u00a0https:\/\/doi.org\/10.1002\/alz.13016","DOI":"10.1002\/alz.13016"},{"issue":"3","key":"4067_CR3","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.3233\/jad-210420","volume":"83","author":"P Ag\u00fcero","year":"2021","unstructured":"Ag\u00fcero P, Sainz MJ, T\u00e9llez R, Lorda I, \u00c1vila A, Garc\u00eda-Ribas G, Rodr\u00edguez PP, G\u00f3mez-Tortosa E (2021) De novo PS1 mutation (Pro436Gln) in a very early-onset posterior variant of Alzheimer\u2019s disease associated with spasticity: a case report. J Alzheimers Dis 83(3):1011\u20131016. https:\/\/doi.org\/10.3233\/jad-210420","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"4067_CR4","doi-asserted-by":"publisher","first-page":"1826","DOI":"10.1111\/jgs.17206","volume":"69","author":"MS Beeri","year":"2021","unstructured":"Beeri MS, Leugrans SE, Delbono O, Bennett DA, Buchman AS (2021) Sarcopenia is associated with incident Alzheimer\u2019s dementia, mild cognitive impairment, and cognitive decline. J Am Geriatr Soc 69(7):1826\u20131835. https:\/\/doi.org\/10.1111\/jgs.17206","journal-title":"J Am Geriatr Soc"},{"issue":"11","key":"4067_CR5","doi-asserted-by":"publisher","first-page":"1339","DOI":"10.1001\/archneurol.2009.240","volume":"66","author":"PA Boyle","year":"2009","unstructured":"Boyle PA, Buchman AS, Wilson RS, Leurgans SE, Bennett DA (2009) Association of muscle strength with the risk of Alzheimer disease and the rate of cognitive decline in community-dwelling older persons. Arch Neurol 66(11):1339\u20131344. https:\/\/doi.org\/10.1001\/archneurol.2009.240","journal-title":"Arch Neurol"},{"key":"4067_CR6","doi-asserted-by":"publisher","unstructured":"Pereira TMC, C\u00f4co LZ, Ton AMM, Meyrelles SS, Campos-Toimil M, Campagnaro BP, Vasquez EC (2021) The emerging scenario of the gut-brain axis: the therapeutic actions of the new actor kefir against neurodegenerative diseases. Antioxidants (Basel) 10(11).https:\/\/doi.org\/10.3390\/antiox10111845.","DOI":"10.3390\/antiox10111845"},{"key":"4067_CR7","doi-asserted-by":"publisher","unstructured":"Szegeczki V, Horv\u00e1th G, Per\u00e9nyi H, Tam\u00e1s A, Rad\u00e1k Z, \u00c1brah\u00e1m D, Z\u00e1k\u00e1ny R, Reglodi D, et al. (2020) Alzheimer\u2019s disease mouse as a model of testis degeneration. Int J Mol Sci 21(16).\u00a0https:\/\/doi.org\/10.3390\/ijms21165726","DOI":"10.3390\/ijms21165726"},{"issue":"8","key":"4067_CR8","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.jacc.2019.10.062","volume":"75","author":"M Cortes-Canteli","year":"2020","unstructured":"Cortes-Canteli M, Iadecola C (2020) Alzheimer\u2019s disease and vascular aging: JACC focus seminar. J Am Coll Cardiol 75(8):942\u2013951. https:\/\/doi.org\/10.1016\/j.jacc.2019.10.062","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"4067_CR9","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.jchf.2018.10.022","volume":"7","author":"GD Sanna","year":"2019","unstructured":"Sanna GD, Nusdeo G, Piras MR, Forteleoni A, Murru MR, Saba PS, Dore S, Sotgiu G et al (2019) Cardiac abnormalities in Alzheimer disease: clinical relevance beyond pathophysiological rationale and instrumental findings? JACC Heart Fail 7(2):121\u2013128. https:\/\/doi.org\/10.1016\/j.jchf.2018.10.022","journal-title":"JACC Heart Fail"},{"key":"4067_CR10","doi-asserted-by":"publisher","unstructured":"Kaur H, Seeger D, Golovko S, Golovko M, Combs CK (2021) Liver bile acid changes in mouse models of Alzheimer\u2019s disease. Int J Mol Sci 22(14).\u00a0https:\/\/doi.org\/10.3390\/ijms22147451","DOI":"10.3390\/ijms22147451"},{"issue":"11","key":"4067_CR11","doi-asserted-by":"publisher","first-page":"1967","DOI":"10.1007\/s00134-007-0788-7","volume":"33","author":"EJ Kompanje","year":"2007","unstructured":"Kompanje EJ, Jansen TC, van der Hoven B, Bakker J (2007) The first demonstration of lactic acid in human blood in shock by Johann Joseph Scherer (1814\u20131869) in January 1843. Intensive Care Med 33(11):1967\u20131971. https:\/\/doi.org\/10.1007\/s00134-007-0788-7","journal-title":"Intensive Care Med"},{"issue":"5","key":"4067_CR12","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.tibs.2016.02.003","volume":"41","author":"R Haas","year":"2016","unstructured":"Haas R, Cucchi D, Smith J, Pucino V, Macdougall CE, Mauro C (2016) Intermediates of metabolism: from bystanders to signalling molecules. Trends Biochem Sci 41(5):460\u2013471. https:\/\/doi.org\/10.1016\/j.tibs.2016.02.003","journal-title":"Trends Biochem Sci"},{"issue":"3","key":"4067_CR13","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1124\/jpet.112.192799","volume":"341","author":"C Liu","year":"2012","unstructured":"Liu C, Kuei C, Zhu J, Yu J, Zhang L, Shih A, Mirzadegan T, Shelton J et al (2012) 3,5-Dihydroxybenzoic acid, a specific agonist for hydroxycarboxylic acid 1, inhibits lipolysis in adipocytes. J Pharmacol Exp Ther 341(3):794\u2013801. https:\/\/doi.org\/10.1124\/jpet.112.192799","journal-title":"J Pharmacol Exp Ther"},{"issue":"6","key":"4067_CR14","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1152\/physiol.00016.2017","volume":"32","author":"S Sun","year":"2017","unstructured":"Sun S, Li H, Chen J, Qian Q (2017) Lactic acid: no longer an inert and end-product of glycolysis. Physiology (Bethesda) 32(6):453\u2013463. https:\/\/doi.org\/10.1152\/physiol.00016.2017","journal-title":"Physiology (Bethesda)"},{"key":"4067_CR15","doi-asserted-by":"publisher","unstructured":"Hadzic A, Nguyen TD, Hosoyamada M, Tomioka NH, Bergersen LH, Storm-Mathisen J, Morland C (2020) The lactate receptor HCA(1) is present in the choroid plexus, the tela choroidea, and the neuroepithelial lining of the dorsal part of the third ventricle. Int J Mol Sci 21(18).\u00a0https:\/\/doi.org\/10.3390\/ijms21186457","DOI":"10.3390\/ijms21186457"},{"issue":"5","key":"4067_CR16","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1124\/mol.111.074500","volume":"80","author":"C Kuei","year":"2011","unstructured":"Kuei C, Yu J, Zhu J, Wu J, Zhang L, Shih A, Mirzadegan T, Lovenberg T et al (2011) Study of GPR81, the lactate receptor, from distant species identifies residues and motifs critical for GPR81 functions. Mol Pharmacol 80(5):848\u2013858. https:\/\/doi.org\/10.1124\/mol.111.074500","journal-title":"Mol Pharmacol"},{"issue":"4","key":"4067_CR17","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1194\/jlr.M700513-JLR200","volume":"49","author":"H Ge","year":"2008","unstructured":"Ge H, Weiszmann J, Reagan JD, Gupte J, Baribault H, Gyuris T, Chen JL, Tian H et al (2008) Elucidation of signaling and functional activities of an orphan GPCR, GPR81. J Lipid Res 49(4):797\u2013803. https:\/\/doi.org\/10.1194\/jlr.M700513-JLR200","journal-title":"J Lipid Res"},{"key":"4067_CR18","doi-asserted-by":"publisher","first-page":"107451","DOI":"10.1016\/j.pharmthera.2019.107451","volume":"206","author":"TP Brown","year":"2020","unstructured":"Brown TP, Ganapathy V (2020) Lactate\/GPR81 signaling and proton motive force in cancer: role in angiogenesis, immune escape, nutrition, and Warburg phenomenon. Pharmacol Ther 206:107451. https:\/\/doi.org\/10.1016\/j.pharmthera.2019.107451","journal-title":"Pharmacol Ther"},{"key":"4067_CR19","doi-asserted-by":"publisher","first-page":"15557","DOI":"10.1038\/ncomms15557","volume":"8","author":"C Morland","year":"2017","unstructured":"Morland C, Andersson KA, Haugen \u00d8P, Hadzic A, Kleppa L, Gille A, Rinholm JE, Palibrk V, et al (2017) Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1. Nat Commun 8:15557. https:\/\/doi.org\/10.1038\/ncomms15557","journal-title":"Nat Commun"},{"issue":"6","key":"4067_CR20","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1002\/glia.23250","volume":"66","author":"CM Alberini","year":"2018","unstructured":"Alberini CM, Cruz E, Descalzi G, Bessi\u00e8res B, Gao V (2018) Astrocyte glycogen and lactate: new insights into learning and memory mechanisms. Glia 66(6):1244\u20131262. https:\/\/doi.org\/10.1002\/glia.23250","journal-title":"Glia"},{"key":"4067_CR21","doi-asserted-by":"publisher","first-page":"101479","DOI":"10.1016\/j.arr.2021.101479","volume":"72","author":"S L\u00f3pez-Ortiz","year":"2021","unstructured":"L\u00f3pez-Ortiz S, Valenzuela PL, Seisdedos MM, Morales JS, Vega T, Castillo-Garc\u00eda A, Nistic\u00f2 R, Mercuri NB et al (2021) Exercise interventions in Alzheimer\u2019s disease: a systematic review and meta-analysis of randomized controlled trials. Ageing Res Rev 72:101479. https:\/\/doi.org\/10.1016\/j.arr.2021.101479","journal-title":"Ageing Res Rev"},{"key":"4067_CR22","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.cytogfr.2022.11.001","volume":"68","author":"L Ye","year":"2022","unstructured":"Ye L, Jiang Y, Zhang M (2022) Crosstalk between glucose metabolism, lactate production and immune response modulation. Cytokine Growth Factor Rev 68:81\u201392. https:\/\/doi.org\/10.1016\/j.cytogfr.2022.11.001","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"4067_CR23","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1097\/00005768-200206000-00021","volume":"34","author":"J Baker","year":"2002","unstructured":"Baker J, Brown E, Hill G, Phillips G, Williams R, Davies B (2002) Handgrip contribution to lactate production and leg power during high-intensity exercise. Med Sci Sports Exerc 34(6):1037\u20131040. https:\/\/doi.org\/10.1097\/00005768-200206000-00021","journal-title":"Med Sci Sports Exerc"},{"issue":"2","key":"4067_CR24","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.ccc.2009.12.007","volume":"26","author":"C Vernon","year":"2010","unstructured":"Vernon C, Letourneau JL (2010) Lactic acidosis: recognition, kinetics, and associated prognosis. Crit Care Clin 26(2):255\u2013283. https:\/\/doi.org\/10.1016\/j.ccc.2009.12.007","journal-title":"Crit Care Clin"},{"issue":"3","key":"4067_CR25","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1152\/jappl.1978.44.3.350","volume":"44","author":"L Jorfeldt","year":"1978","unstructured":"Jorfeldt L, Juhlin-Dannfelt A, Karlsson J (1978) Lactate release in relation to tissue lactate in human skeletal muscle during exercise. J Appl Physiol Respir Environ Exerc Physiol 44(3):350\u2013352. https:\/\/doi.org\/10.1152\/jappl.1978.44.3.350","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"issue":"4","key":"4067_CR26","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1097\/00003677-200510000-00002","volume":"33","author":"RG Shulman","year":"2005","unstructured":"Shulman RG (2005) Glycogen turnover forms lactate during exercise. Exerc Sport Sci Rev 33(4):157\u2013162. https:\/\/doi.org\/10.1097\/00003677-200510000-00002","journal-title":"Exerc Sport Sci Rev"},{"issue":"5 Pt 1","key":"4067_CR27","doi-asserted-by":"publisher","first-page":"E555","DOI":"10.1152\/ajpendo.1988.254.5.E555","volume":"254","author":"EA Richter","year":"1988","unstructured":"Richter EA, Kiens B, Saltin B, Christensen NJ, Savard G (1988) Skeletal muscle glucose uptake during dynamic exercise in humans: role of muscle mass. Am J Physiol 254(5 Pt 1):E555-561. https:\/\/doi.org\/10.1152\/ajpendo.1988.254.5.E555","journal-title":"Am J Physiol"},{"issue":"8","key":"4067_CR28","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1249\/00005768-199408000-00009","volume":"26","author":"TB Price","year":"1994","unstructured":"Price TB, Taylor R, Mason GF, Rothman DL, Shulman GI, Shulman RG (1994) Turnover of human muscle glycogen with low-intensity exercise. Med Sci Sports Exerc 26(8):983\u2013991","journal-title":"Med Sci Sports Exerc"},{"key":"4067_CR29","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101454","volume":"35","author":"GA Brooks","year":"2020","unstructured":"Brooks GA (2020) Lactate as a fulcrum of metabolism. Redox Biol 35:101454. https:\/\/doi.org\/10.1016\/j.redox.2020.101454","journal-title":"Redox Biol"},{"issue":"3","key":"4067_CR30","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.cmet.2019.06.005","volume":"30","author":"SH Baik","year":"2019","unstructured":"Baik SH, Kang S, Lee W, Choi H, Chung S, Kim JI, Mook-Jung I (2019) A breakdown in metabolic reprogramming causes microglia dysfunction in Alzheimer\u2019s disease. Cell Metab 30(3):493-507.e496. https:\/\/doi.org\/10.1016\/j.cmet.2019.06.005","journal-title":"Cell Metab"},{"key":"4067_CR31","doi-asserted-by":"publisher","unstructured":"Solas M, Zamarbide M, Ardanaz CG, Ram\u00edrez MJ, P\u00e9rez-Mediavilla A (2022) The cognitive improvement and alleviation of brain hypermetabolism caused by FFAR3 ablation in Tg2576 mice is persistent under diet-induced obesity. Int J Mol Sci 23(21).https:\/\/doi.org\/10.3390\/ijms232113591.","DOI":"10.3390\/ijms232113591"},{"issue":"1","key":"4067_CR32","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1111\/jnc.14608","volume":"149","author":"P Cisternas","year":"2019","unstructured":"Cisternas P, Zolezzi JM, Martinez M, Torres VI, Wong GW, Inestrosa NC (2019) Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease. J Neurochem 149(1):54\u201372. https:\/\/doi.org\/10.1111\/jnc.14608","journal-title":"J Neurochem"},{"issue":"11","key":"4067_CR33","doi-asserted-by":"publisher","first-page":"7653","DOI":"10.1002\/jcp.29682","volume":"235","author":"BL Tang","year":"2020","unstructured":"Tang BL (2020) Glucose, glycolysis, and neurodegenerative diseases. J Cell Physiol 235(11):7653\u20137662. https:\/\/doi.org\/10.1002\/jcp.29682","journal-title":"J Cell Physiol"},{"key":"4067_CR34","doi-asserted-by":"publisher","first-page":"3419034","DOI":"10.1155\/2020\/3419034","volume":"2020","author":"M Pohanka","year":"2020","unstructured":"Pohanka M (2020) D-lactic acid as a metabolite: toxicology, diagnosis, and detection. Biomed Res Int 2020:3419034. https:\/\/doi.org\/10.1155\/2020\/3419034","journal-title":"Biomed Res Int"},{"key":"4067_CR35","doi-asserted-by":"publisher","unstructured":"Proia P, Di Liegro CM, Schiera G, Fricano A, Di Liegro I (2016) Lactate as a metabolite and a regulator in the central nervous system. Int J Mol Sci 17(9).\u00a0https:\/\/doi.org\/10.3390\/ijms17091450","DOI":"10.3390\/ijms17091450"},{"issue":"4","key":"4067_CR36","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.cmet.2018.03.008","volume":"27","author":"GA Brooks","year":"2018","unstructured":"Brooks GA (2018) The science and translation of lactate shuttle theory. Cell Metab 27(4):757\u2013785. https:\/\/doi.org\/10.1016\/j.cmet.2018.03.008","journal-title":"Cell Metab"},{"key":"4067_CR37","unstructured":"Dunn J, Grider MH (2023) Physiology, adenosine triphosphate. In: StatPearls. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2023, StatPearls Publishing LLC"},{"issue":"49","key":"4067_CR38","doi-asserted-by":"publisher","first-page":"19345","DOI":"10.1073\/pnas.0709747104","volume":"104","author":"RJ DeBerardinis","year":"2007","unstructured":"DeBerardinis RJ, Mancuso A, Daikhin E, Nissim I, Yudkoff M, Wehrli S, Thompson CB (2007) Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis. Proc Natl Acad Sci U S A 104(49):19345\u201319350. https:\/\/doi.org\/10.1073\/pnas.0709747104","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"4067_CR39","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1038\/s42255-020-0243-4","volume":"2","author":"JD Rabinowitz","year":"2020","unstructured":"Rabinowitz JD, Enerb\u00e4ck S (2020) Lactate: the ugly duckling of energy metabolism. Nat Metab 2(7):566\u2013571. https:\/\/doi.org\/10.1038\/s42255-020-0243-4","journal-title":"Nat Metab"},{"key":"4067_CR40","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.coi.2014.01.006","volume":"27","author":"JA Maciolek","year":"2014","unstructured":"Maciolek JA, Pasternak JA, Wilson HL (2014) Metabolism of activated T lymphocytes. Curr Opin Immunol 27:60\u201374. https:\/\/doi.org\/10.1016\/j.coi.2014.01.006","journal-title":"Curr Opin Immunol"},{"issue":"4","key":"4067_CR41","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1111\/j.1748-1716.2010.02122.x","volume":"199","author":"G van Hall","year":"2010","unstructured":"van Hall G (2010) Lactate kinetics in human tissues at rest and during exercise. Acta Physiol (Oxf) 199(4):499\u2013508. https:\/\/doi.org\/10.1111\/j.1748-1716.2010.02122.x","journal-title":"Acta Physiol (Oxf)"},{"issue":"7","key":"4067_CR42","doi-asserted-by":"publisher","first-page":"1152","DOI":"10.1038\/jcbfm.2011.149","volume":"32","author":"L Pellerin","year":"2012","unstructured":"Pellerin L, Magistretti PJ (2012) Sweet sixteen for ANLS. J Cereb Blood Flow Metab 32(7):1152\u20131166. https:\/\/doi.org\/10.1038\/jcbfm.2011.149","journal-title":"J Cereb Blood Flow Metab"},{"issue":"12","key":"4067_CR43","doi-asserted-by":"publisher","first-page":"e1194","DOI":"10.1097\/ccm.0000000000004589","volume":"48","author":"Y Bennis","year":"2020","unstructured":"Bennis Y, Bodeau S, Batteux B, Gras-Champel V, Masmoudi K, Maizel J, De Broe ME, Lalau JD et al (2020) A study of associations between plasma metformin concentration, lactic acidosis, and mortality in an emergency hospitalization context. Crit Care Med 48(12):e1194\u2013e1202. https:\/\/doi.org\/10.1097\/ccm.0000000000004589","journal-title":"Crit Care Med"},{"issue":"Pt 23","key":"4067_CR44","doi-asserted-by":"publisher","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","volume":"587","author":"GA Brooks","year":"2009","unstructured":"Brooks GA (2009) Cell-cell and intracellular lactate shuttles. J Physiol 587(Pt 23):5591\u20135600. https:\/\/doi.org\/10.1113\/jphysiol.2009.178350","journal-title":"J Physiol"},{"issue":"2\u20133","key":"4067_CR45","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.mam.2012.05.003","volume":"34","author":"AP Halestrap","year":"2013","unstructured":"Halestrap AP (2013) The SLC16 gene family - structure, role and regulation in health and disease. Mol Aspects Med 34(2\u20133):337\u2013349. https:\/\/doi.org\/10.1016\/j.mam.2012.05.003","journal-title":"Mol Aspects Med"},{"issue":"1","key":"4067_CR46","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neuroscience.2006.11.062","volume":"145","author":"LH Bergersen","year":"2007","unstructured":"Bergersen LH (2007) Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145(1):11\u201319. https:\/\/doi.org\/10.1016\/j.neuroscience.2006.11.062","journal-title":"Neuroscience"},{"issue":"4","key":"4067_CR47","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrn.2018.19","volume":"19","author":"PJ Magistretti","year":"2018","unstructured":"Magistretti PJ, Allaman I (2018) Lactate in the brain: from metabolic end-product to signalling molecule. Nat Rev Neurosci 19(4):235\u2013249. https:\/\/doi.org\/10.1038\/nrn.2018.19","journal-title":"Nat Rev Neurosci"},{"issue":"6","key":"4067_CR48","doi-asserted-by":"publisher","first-page":"2017","DOI":"10.1172\/jci113822","volume":"82","author":"EW Gertz","year":"1988","unstructured":"Gertz EW, Wisneski JA, Stanley WC, Neese RA (1988) Myocardial substrate utilization during exercise in humans. Dual carbon-labeled carbohydrate isotope experiments. J Clin Invest 82(6):2017\u20132025. https:\/\/doi.org\/10.1172\/jci113822","journal-title":"J Clin Invest"},{"issue":"Pt 11","key":"4067_CR49","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1113\/jphysiol.2009.186767","volume":"588","author":"P Rasmussen","year":"2010","unstructured":"Rasmussen P, Nielsen J, Overgaard M, Krogh-Madsen R, Gjedde A, Secher NH, Petersen NC (2010) Reduced muscle activation during exercise related to brain oxygenation and metabolism in humans. J Physiol 588(Pt 11):1985\u20131995. https:\/\/doi.org\/10.1113\/jphysiol.2009.186767","journal-title":"J Physiol"},{"issue":"5","key":"4067_CR50","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.cell.2011.02.018","volume":"144","author":"A Suzuki","year":"2011","unstructured":"Suzuki A, Stern SA, Bozdagi O, Huntley GW, Walker RH, Magistretti PJ, Alberini CM (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144(5):810\u2013823. https:\/\/doi.org\/10.1016\/j.cell.2011.02.018","journal-title":"Cell"},{"issue":"7223","key":"4067_CR51","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/nature07525","volume":"456","author":"GR Gordon","year":"2008","unstructured":"Gordon GR, Choi HB, Rungta RL, Ellis-Davies GC, MacVicar BA (2008) Brain metabolism dictates the polarity of astrocyte control over arterioles. Nature 456(7223):745\u2013749. https:\/\/doi.org\/10.1038\/nature07525","journal-title":"Nature"},{"issue":"1","key":"4067_CR52","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/s12986-022-00687-z","volume":"19","author":"X Xue","year":"2022","unstructured":"Xue X, Liu B, Hu J, Bian X, Lou S (2022) The potential mechanisms of lactate in mediating exercise-enhanced cognitive function: a dual role as an energy supply substrate and a signaling molecule. Nutr Metab (Lond) 19(1):52. https:\/\/doi.org\/10.1186\/s12986-022-00687-z","journal-title":"Nutr Metab (Lond)"},{"issue":"12","key":"4067_CR53","doi-asserted-by":"publisher","first-page":"e28427","DOI":"10.1371\/journal.pone.0028427","volume":"6","author":"LA Newman","year":"2011","unstructured":"Newman LA, Korol DL, Gold PE (2011) Lactate produced by glycogenolysis in astrocytes regulates memory processing. PLoS ONE 6(12):e28427. https:\/\/doi.org\/10.1371\/journal.pone.0028427","journal-title":"PLoS ONE"},{"issue":"6","key":"4067_CR54","doi-asserted-by":"publisher","first-page":"1687","DOI":"10.1111\/j.1460-9568.2006.05056.x","volume":"24","author":"AK Bouzier-Sore","year":"2006","unstructured":"Bouzier-Sore AK, Voisin P, Bouchaud V, Bezancon E, Franconi JM, Pellerin L (2006) Competition between glucose and lactate as oxidative energy substrates in both neurons and astrocytes: a comparative NMR study. Eur J Neurosci 24(6):1687\u20131694. https:\/\/doi.org\/10.1111\/j.1460-9568.2006.05056.x","journal-title":"Eur J Neurosci"},{"issue":"1","key":"4067_CR55","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1471-4159.2005.03168.x","volume":"94","author":"K Pierre","year":"2005","unstructured":"Pierre K, Pellerin L (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94(1):1\u201314. https:\/\/doi.org\/10.1111\/j.1471-4159.2005.03168.x","journal-title":"J Neurochem"},{"issue":"6","key":"4067_CR56","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.cmet.2011.08.016","volume":"14","author":"M B\u00e9langer","year":"2011","unstructured":"B\u00e9langer M, Allaman I, Magistretti PJ (2011) Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. Cell Metab 14(6):724\u2013738. https:\/\/doi.org\/10.1016\/j.cmet.2011.08.016","journal-title":"Cell Metab"},{"issue":"4","key":"4067_CR57","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.neuron.2015.03.035","volume":"86","author":"PJ Magistretti","year":"2015","unstructured":"Magistretti PJ, Allaman I (2015) A cellular perspective on brain energy metabolism and functional imaging. Neuron 86(4):883\u2013901. https:\/\/doi.org\/10.1016\/j.neuron.2015.03.035","journal-title":"Neuron"},{"issue":"33","key":"4067_CR58","doi-asserted-by":"publisher","first-page":"e2204619119","DOI":"10.1073\/pnas.2204619119","volume":"119","author":"V Medel","year":"2022","unstructured":"Medel V, Crossley N, Gajardo I, Muller E, Barros LF, Shine JM, Sierralta J (2022) Whole-brain neuronal MCT2 lactate transporter expression links metabolism to human brain structure and function. Proc Natl Acad Sci U S A 119(33):e2204619119. https:\/\/doi.org\/10.1073\/pnas.2204619119","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"4067_CR59","doi-asserted-by":"publisher","first-page":"607","DOI":"10.1113\/jphysiol.2011.217919","volume":"590","author":"T Matsui","year":"2012","unstructured":"Matsui T, Ishikawa T, Ito H, Okamoto M, Inoue K, Lee MC, Fujikawa T, Ichitani Y et al (2012) Brain glycogen supercompensation following exhaustive exercise. J Physiol 590(3):607\u2013616. https:\/\/doi.org\/10.1113\/jphysiol.2011.217919","journal-title":"J Physiol"},{"key":"4067_CR60","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3389\/fnint.2015.00070","volume":"9","author":"ME Gibbs","year":"2015","unstructured":"Gibbs ME (2015) Role of glycogenolysis in memory and learning: regulation by noradrenaline, serotonin and ATP. Front Integr Neurosci 9:70. https:\/\/doi.org\/10.3389\/fnint.2015.00070","journal-title":"Front Integr Neurosci"},{"key":"4067_CR61","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.gene.2019.04.027","volume":"704","author":"H Kerendi","year":"2019","unstructured":"Kerendi H, Rahmati M, Mirnasuri R, Kazemi A (2019) High intensity interval training decreases the expressions of KIF5B and dynein in hippocampus of Wistar male rats. Gene 704:8\u201314. https:\/\/doi.org\/10.1016\/j.gene.2019.04.027","journal-title":"Gene"},{"issue":"6228","key":"4067_CR62","doi-asserted-by":"publisher","first-page":"1362","DOI":"10.1126\/science.aaa1299","volume":"347","author":"N Sada","year":"2015","unstructured":"Sada N, Lee S, Katsu T, Otsuki T, Inoue T (2015) Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science 347(6228):1362\u20131367. https:\/\/doi.org\/10.1126\/science.aaa1299","journal-title":"Science"},{"key":"4067_CR63","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.gene.2019.01.013","volume":"692","author":"M Rahmati","year":"2019","unstructured":"Rahmati M, Kazemi A (2019) Various exercise intensities differentially regulate GAP-43 and CAP-1 expression in the rat hippocampus. Gene 692:185\u2013194. https:\/\/doi.org\/10.1016\/j.gene.2019.01.013","journal-title":"Gene"},{"issue":"1","key":"4067_CR64","first-page":"33","volume":"43","author":"G Sole","year":"2015","unstructured":"Sole G (2015) ESSA\u2019s student manual for health, exercise and sport assessment (2014). N Z J Physiother 43(1):33","journal-title":"N Z J Physiother"},{"issue":"6","key":"4067_CR65","doi-asserted-by":"publisher","first-page":"469","DOI":"10.2165\/00007256-200939060-00003","volume":"39","author":"O Faude","year":"2009","unstructured":"Faude O, Kindermann W, Meyer T (2009) Lactate threshold concepts: how valid are they? Sports Med 39(6):469\u2013490. https:\/\/doi.org\/10.2165\/00007256-200939060-00003","journal-title":"Sports Med"},{"issue":"10","key":"4067_CR66","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1007\/s40279-020-01322-8","volume":"50","author":"NA Jamnick","year":"2020","unstructured":"Jamnick NA, Pettitt RW, Granata C, Pyne DB, Bishop DJ (2020) An examination and critique of current methods to determine exercise intensity. Sports Med 50(10):1729\u20131756. https:\/\/doi.org\/10.1007\/s40279-020-01322-8","journal-title":"Sports Med"},{"issue":"9","key":"4067_CR67","doi-asserted-by":"publisher","first-page":"1965","DOI":"10.1097\/00003246-199909000-00041","volume":"27","author":"JC Goodman","year":"1999","unstructured":"Goodman JC, Valadka AB, Gopinath SP, Uzura M, Robertson CS (1999) Extracellular lactate and glucose alterations in the brain after head injury measured by microdialysis. Crit Care Med 27(9):1965\u20131973. https:\/\/doi.org\/10.1097\/00003246-199909000-00041","journal-title":"Crit Care Med"},{"issue":"4","key":"4067_CR68","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1097\/00000542-199210000-00017","volume":"77","author":"M Harada","year":"1992","unstructured":"Harada M, Okuda C, Sawa T, Murakami T (1992) Cerebral extracellular glucose and lactate concentrations during and after moderate hypoxia in glucose- and saline-infused rats. Anesthesiology 77(4):728\u2013734. https:\/\/doi.org\/10.1097\/00000542-199210000-00017","journal-title":"Anesthesiology"},{"issue":"42","key":"4067_CR69","doi-asserted-by":"publisher","first-page":"13983","DOI":"10.1523\/jneurosci.2040-10.2010","volume":"30","author":"F Boumezbeur","year":"2010","unstructured":"Boumezbeur F, Petersen KF, Cline GW, Mason GF, Behar KL, Shulman GI, Rothman DL (2010) The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci 30(42):13983\u201313991. https:\/\/doi.org\/10.1523\/jneurosci.2040-10.2010","journal-title":"J Neurosci"},{"issue":"9","key":"4067_CR70","doi-asserted-by":"publisher","first-page":"e0184240","DOI":"10.1371\/journal.pone.0184240","volume":"12","author":"F Lucertini","year":"2017","unstructured":"Lucertini F, Gervasi M, D\u2019Amen G, Sisti D, Rocchi MBL, Stocchi V, Benelli P (2017) Effect of water-based recovery on blood lactate removal after high-intensity exercise. PLoS ONE 12(9):e0184240. https:\/\/doi.org\/10.1371\/journal.pone.0184240","journal-title":"PLoS ONE"},{"issue":"10","key":"4067_CR71","doi-asserted-by":"publisher","first-page":"725","DOI":"10.2165\/00007256-200131100-00003","volume":"31","author":"PB Gastin","year":"2001","unstructured":"Gastin PB (2001) Energy system interaction and relative contribution during maximal exercise. Sports Med 31(10):725\u2013741. https:\/\/doi.org\/10.2165\/00007256-200131100-00003","journal-title":"Sports Med"},{"issue":"1","key":"4067_CR72","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1152\/jappl.1991.71.1.333","volume":"71","author":"GA Brooks","year":"1991","unstructured":"Brooks GA, Butterfield GE, Wolfe RR, Groves BM, Mazzeo RS, Sutton JR, Wolfel EE (1991) Decreased reliance on lactate during exercise after acclimatization to 4,300 m. J Appl Physiol (1985) 71(1):333\u2013341. https:\/\/doi.org\/10.1152\/jappl.1991.71.1.333","journal-title":"J Appl Physiol (1985)"},{"issue":"9","key":"4067_CR73","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1007\/bf03345235","volume":"26","author":"P De Feo","year":"2003","unstructured":"De Feo P, Di Loreto C, Lucidi P, Murdolo G, Parlanti N, De Cicco A, Piccioni F, Santeusanio F (2003) Metabolic response to exercise. J Endocrinol Invest 26(9):851\u2013854. https:\/\/doi.org\/10.1007\/bf03345235","journal-title":"J Endocrinol Invest"},{"issue":"1","key":"4067_CR74","doi-asserted-by":"publisher","first-page":"2535","DOI":"10.1038\/s41598-023-29406-1","volume":"13","author":"M Rahmati","year":"2023","unstructured":"Rahmati M, Shariatzadeh Joneydi M, Koyanagi A, Yang G, Ji B, Won Lee S, Keon Yon D et al (2023) Resistance training restores skeletal muscle atrophy and satellite cell content in an animal model of Alzheimer\u2019s disease. Sci Rep 13(1):2535. https:\/\/doi.org\/10.1038\/s41598-023-29406-1","journal-title":"Sci Rep"},{"issue":"6","key":"4067_CR75","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s10522-020-09895-7","volume":"21","author":"T T\u00e9gl\u00e1s","year":"2020","unstructured":"T\u00e9gl\u00e1s T, \u00c1brah\u00e1m D, J\u00f3kai M, Kondo S, Mohammadi R, Feh\u00e9r J, Szab\u00f3 D, Wilhelm M et al (2020) Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP\/PS1 transgenic mice. Biogerontology 21(6):807\u2013815. https:\/\/doi.org\/10.1007\/s10522-020-09895-7","journal-title":"Biogerontology"},{"issue":"9 Pt B","key":"4067_CR76","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1016\/j.neubiorev.2013.04.005","volume":"37","author":"K H\u00f6tting","year":"2013","unstructured":"H\u00f6tting K, R\u00f6der B (2013) Beneficial effects of physical exercise on neuroplasticity and cognition. Neurosci Biobehav Rev 37(9 Pt B):2243\u20132257. https:\/\/doi.org\/10.1016\/j.neubiorev.2013.04.005","journal-title":"Neurosci Biobehav Rev"},{"issue":"3","key":"4067_CR77","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1111\/cns.12362","volume":"21","author":"Z Shen","year":"2015","unstructured":"Shen Z, Jiang L, Yuan Y, Deng T, Zheng YR, Zhao YY, Li WL, Wu JY et al (2015) Inhibition of G protein-coupled receptor 81 (GPR81) protects against ischemic brain injury. CNS Neurosci Ther 21(3):271\u2013279. https:\/\/doi.org\/10.1111\/cns.12362","journal-title":"CNS Neurosci Ther"},{"issue":"3","key":"4067_CR78","doi-asserted-by":"publisher","first-page":"e93041","DOI":"10.1371\/journal.pone.0093041","volume":"9","author":"G Li","year":"2014","unstructured":"Li G, Wang HQ, Wang LH, Chen RP, Liu JP (2014) Distinct pathways of ERK1\/2 activation by hydroxy-carboxylic acid receptor-1. PLoS ONE 9(3):e93041. https:\/\/doi.org\/10.1371\/journal.pone.0093041","journal-title":"PLoS ONE"},{"issue":"39","key":"4067_CR79","doi-asserted-by":"publisher","first-page":"26385","DOI":"10.1074\/jbc.M109.040741","volume":"284","author":"EH Jeninga","year":"2009","unstructured":"Jeninga EH, Bugge A, Nielsen R, Kersten S, Hamers N, Dani C, Wabitsch M, Berger R et al (2009) Peroxisome proliferator-activated receptor gamma regulates expression of the anti-lipolytic G-protein-coupled receptor 81 (GPR81\/Gpr81). J Biol Chem 284(39):26385\u201326393. https:\/\/doi.org\/10.1074\/jbc.M109.040741","journal-title":"J Biol Chem"},{"issue":"9","key":"4067_CR80","doi-asserted-by":"publisher","first-page":"1878","DOI":"10.1016\/j.ajpath.2019.05.016","volume":"189","author":"A Madaan","year":"2019","unstructured":"Madaan A, Chaudhari P, Nadeau-Vall\u00e9e M, Hamel D, Zhu T, Mitchell G, Samuels M, Pundir S et al (2019) M\u00fcller cell-localized G-protein-coupled receptor 81 (hydroxycarboxylic acid receptor 1) regulates inner retinal vasculature via norrin\/Wnt pathways. Am J Pathol 189(9):1878\u20131896. https:\/\/doi.org\/10.1016\/j.ajpath.2019.05.016","journal-title":"Am J Pathol"},{"issue":"2","key":"4067_CR81","doi-asserted-by":"publisher","first-page":"R372","DOI":"10.1152\/ajpregu.00525.2009","volume":"298","author":"T Seifert","year":"2010","unstructured":"Seifert T, Brassard P, Wissenberg M, Rasmussen P, Nordby P, Stallknecht B, Adser H, Jakobsen AH et al (2010) Endurance training enhances BDNF release from the human brain. Am J Physiol Regul Integr Comp Physiol 298(2):R372-377. https:\/\/doi.org\/10.1152\/ajpregu.00525.2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"6","key":"4067_CR82","doi-asserted-by":"publisher","first-page":"e0128720","DOI":"10.1371\/journal.pone.0128720","volume":"10","author":"K Inoue","year":"2015","unstructured":"Inoue K, Okamoto M, Shibato J, Lee MC, Matsui T, Rakwal R, Soya H (2015) Long-term mild, rather than intense, exercise enhances adult hippocampal neurogenesis and greatly changes the transcriptomic profile of the hippocampus. PLoS ONE 10(6):e0128720. https:\/\/doi.org\/10.1371\/journal.pone.0128720","journal-title":"PLoS ONE"},{"key":"4067_CR83","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.nlm.2014.08.004","volume":"116","author":"K Skriver","year":"2014","unstructured":"Skriver K, Roig M, Lundbye-Jensen J, Pingel J, Helge JW, Kiens B, Nielsen JB (2014) Acute exercise improves motor memory: exploring potential biomarkers. Neurobiol Learn Mem 116:46\u201358. https:\/\/doi.org\/10.1016\/j.nlm.2014.08.004","journal-title":"Neurobiol Learn Mem"},{"key":"4067_CR84","doi-asserted-by":"publisher","unstructured":"Di Benedetto G, Iannucci LF, Surdo NC, Zanin S, Conca F, Grisan F, Gerbino A, Lefkimmiatis K (2021) Compartmentalized signaling in aging and neurodegeneration. Cells 10(2).\u00a0https:\/\/doi.org\/10.3390\/cells10020464","DOI":"10.3390\/cells10020464"},{"issue":"33","key":"4067_CR85","doi-asserted-by":"publisher","first-page":"12228","DOI":"10.1073\/pnas.1322912111","volume":"111","author":"J Yang","year":"2014","unstructured":"Yang J, Ruchti E, Petit JM, Jourdain P, Grenningloh G, Allaman I, Magistretti PJ (2014) Lactate promotes plasticity gene expression by potentiating NMDA signaling in neurons. Proc Natl Acad Sci U S A 111(33):12228\u201312233. https:\/\/doi.org\/10.1073\/pnas.1322912111","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7359","key":"4067_CR86","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1038\/nature10243","volume":"476","author":"M Wang","year":"2011","unstructured":"Wang M, Gamo NJ, Yang Y, Jin LE, Wang XJ, Laubach M, Mazer JA, Lee D et al (2011) Neuronal basis of age-related working memory decline. Nature 476(7359):210\u2013213. https:\/\/doi.org\/10.1038\/nature10243","journal-title":"Nature"},{"issue":"1","key":"4067_CR87","doi-asserted-by":"publisher","first-page":"648","DOI":"10.1007\/s12035-014-9053-6","volume":"53","author":"PK Kamat","year":"2016","unstructured":"Kamat PK, Kalani A, Rai S, Swarnkar S, Tota S, Nath C, Tyagi N (2016) Mechanism of oxidative stress and synapse dysfunction in the pathogenesis of Alzheimer\u2019s disease: understanding the therapeutics strategies. Mol Neurobiol 53(1):648\u2013661. https:\/\/doi.org\/10.1007\/s12035-014-9053-6","journal-title":"Mol Neurobiol"},{"issue":"7","key":"4067_CR88","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1002\/jnr.23593","volume":"93","author":"C Morland","year":"2015","unstructured":"Morland C, Lauritzen KH, Puchades M, Holm-Hansen S, Andersson K, Gjedde A, Attramadal H, Storm-Mathisen J et al (2015) The lactate receptor, G-protein-coupled receptor 81\/hydroxycarboxylic acid receptor 1: expression and action in brain. J Neurosci Res 93(7):1045\u20131055. https:\/\/doi.org\/10.1002\/jnr.23593","journal-title":"J Neurosci Res"},{"issue":"2","key":"4067_CR89","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.phrs.2012.04.005","volume":"66","author":"R Roskoski Jr","year":"2012","unstructured":"Roskoski R Jr (2012) ERK1\/2 MAP kinases: structure, function, and regulation. Pharmacol Res 66(2):105\u2013143. https:\/\/doi.org\/10.1016\/j.phrs.2012.04.005","journal-title":"Pharmacol Res"},{"issue":"12","key":"4067_CR90","doi-asserted-by":"publisher","first-page":"8938","DOI":"10.1002\/jcp.29739","volume":"235","author":"J Hu","year":"2020","unstructured":"Hu J, Cai M, Liu Y, Liu B, Xue X, Ji R, Bian X, Lou S (2020) The roles of GRP81 as a metabolic sensor and inflammatory mediator. J Cell Physiol 235(12):8938\u20138950. https:\/\/doi.org\/10.1002\/jcp.29739","journal-title":"J Cell Physiol"},{"key":"4067_CR91","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.lfs.2019.05.036","volume":"229","author":"Z Fallah Mohammadi","year":"2019","unstructured":"Fallah Mohammadi Z, Falah Mohammadi H, Patel DI (2019) Comparing the effects of progressive and mild intensity treadmill running protocols on neuroprotection of parkinsonian rats. Life Sci 229:219\u2013224. https:\/\/doi.org\/10.1016\/j.lfs.2019.05.036","journal-title":"Life Sci"},{"key":"4067_CR92","doi-asserted-by":"publisher","unstructured":"Oh S, Seo SB, Kim G, Batsukh S, Son KH, Byun K (2023) Poly-D,L-lactic acid stimulates angiogenesis and collagen synthesis in aged animal skin. Int J Mol Sci 24(9).\u00a0https:\/\/doi.org\/10.3390\/ijms24097986","DOI":"10.3390\/ijms24097986"},{"issue":"2","key":"4067_CR93","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1007\/s00401-022-02528-y","volume":"145","author":"S Moonen","year":"2023","unstructured":"Moonen S, Koper MJ, Van Schoor E, Schaeverbeke JM, Vandenberghe R, von Arnim CAF, Tousseyn T, De Strooper B et al (2023) Pyroptosis in Alzheimer\u2019s disease: cell type-specific activation in microglia, astrocytes and neurons. Acta Neuropathol 145(2):175\u2013195. https:\/\/doi.org\/10.1007\/s00401-022-02528-y","journal-title":"Acta Neuropathol"},{"issue":"7","key":"4067_CR94","doi-asserted-by":"publisher","first-page":"2550","DOI":"10.1158\/0008-5472.Can-10-2828","volume":"71","author":"F V\u00e9gran","year":"2011","unstructured":"V\u00e9gran F, Boidot R, Michiels C, Sonveaux P, Feron O (2011) Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-\u03baB\/IL-8 pathway that drives tumor angiogenesis. Cancer Res 71(7):2550\u20132560. https:\/\/doi.org\/10.1158\/0008-5472.Can-10-2828","journal-title":"Cancer Res"},{"issue":"9","key":"4067_CR95","doi-asserted-by":"publisher","first-page":"1310","DOI":"10.1017\/s0007114511004673","volume":"106","author":"K Rooney","year":"2011","unstructured":"Rooney K, Trayhurn P (2011) Lactate and the GPR81 receptor in metabolic regulation: implications for adipose tissue function and fatty acid utilisation by muscle during exercise. Br J Nutr 106(9):1310\u20131316. https:\/\/doi.org\/10.1017\/s0007114511004673","journal-title":"Br J Nutr"},{"key":"4067_CR96","doi-asserted-by":"publisher","first-page":"630380","DOI":"10.3389\/fimmu.2021.630380","volume":"12","author":"HC Lin","year":"2021","unstructured":"Lin HC, Chen YJ, Wei YH, Lin HA, Chen CC, Liu TF, Hsieh YL, Huang KY et al (2021) Lactic acid fermentation is required for NLRP3 inflammasome activation. Front Immunol 12:630380. https:\/\/doi.org\/10.3389\/fimmu.2021.630380","journal-title":"Front Immunol"},{"key":"4067_CR97","doi-asserted-by":"publisher","first-page":"587913","DOI":"10.3389\/fimmu.2020.587913","volume":"11","author":"K Yang","year":"2020","unstructured":"Yang K, Xu J, Fan M, Tu F, Wang X, Ha T, Williams DL, Li C (2020) Lactate suppresses macrophage pro-inflammatory response to LPS stimulation by inhibition of YAP and NF-\u03baB activation via GPR81-mediated signaling. Front Immunol 11:587913. https:\/\/doi.org\/10.3389\/fimmu.2020.587913","journal-title":"Front Immunol"},{"issue":"6","key":"4067_CR98","doi-asserted-by":"publisher","first-page":"3090","DOI":"10.4049\/jimmunol.1300772","volume":"191","author":"A Nasi","year":"2013","unstructured":"Nasi A, Fekete T, Krishnamurthy A, Snowden S, Rajnav\u00f6lgyi E, Catrina AI, Wheelock CE, Vivar N et al (2013) Dendritic cell reprogramming by endogenously produced lactic acid. J Immunol 191(6):3090\u20133099. https:\/\/doi.org\/10.4049\/jimmunol.1300772","journal-title":"J Immunol"},{"issue":"7","key":"4067_CR99","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1053\/j.gastro.2014.03.014","volume":"146","author":"R Hoque","year":"2014","unstructured":"Hoque R, Farooq A, Ghani A, Gorelick F, Mehal WZ (2014) Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. Gastroenterology 146(7):1763\u20131774. https:\/\/doi.org\/10.1053\/j.gastro.2014.03.014","journal-title":"Gastroenterology"},{"key":"4067_CR100","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/s12974-015-0239-2","volume":"12","author":"G Santoni","year":"2015","unstructured":"Santoni G, Cardinali C, Morelli MB, Santoni M, Nabissi M, Amantini C (2015) Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons. J Neuroinflammation 12:21. https:\/\/doi.org\/10.1186\/s12974-015-0239-2","journal-title":"J Neuroinflammation"},{"key":"4067_CR101","doi-asserted-by":"publisher","first-page":"808799","DOI":"10.3389\/fimmu.2021.808799","volume":"12","author":"C Manosalva","year":"2021","unstructured":"Manosalva C, Quiroga J, Hidalgo AI, Alarc\u00f3n P, Anseoleaga N, Hidalgo MA, Burgos RA (2021) Role of lactate in inflammatory processes: friend or foe. Front Immunol 12:808799. https:\/\/doi.org\/10.3389\/fimmu.2021.808799","journal-title":"Front Immunol"},{"key":"4067_CR102","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/978-981-13-1286-1_3","volume":"1090","author":"L Yang","year":"2018","unstructured":"Yang L (2018) Neuronal cAMP\/PKA signaling and energy homeostasis. Adv Exp Med Biol 1090:31\u201348. https:\/\/doi.org\/10.1007\/978-981-13-1286-1_3","journal-title":"Adv Exp Med Biol"},{"issue":"12","key":"4067_CR103","doi-asserted-by":"publisher","first-page":"933","DOI":"10.1016\/j.tips.2020.09.007","volume":"41","author":"MH Omar","year":"2020","unstructured":"Omar MH, Scott JD (2020) AKAP signaling islands: venues for precision pharmacology. Trends Pharmacol Sci 41(12):933\u2013946. https:\/\/doi.org\/10.1016\/j.tips.2020.09.007","journal-title":"Trends Pharmacol Sci"},{"issue":"5","key":"4067_CR104","doi-asserted-by":"publisher","first-page":"1288","DOI":"10.1111\/j.1476-5381.2011.01729.x","volume":"165","author":"T Keravis","year":"2012","unstructured":"Keravis T, Lugnier C (2012) Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments. Br J Pharmacol 165(5):1288\u20131305. https:\/\/doi.org\/10.1111\/j.1476-5381.2011.01729.x","journal-title":"Br J Pharmacol"},{"key":"4067_CR105","doi-asserted-by":"publisher","unstructured":"Zhou Z, Okamoto K, Onodera J, Hiragi T, Andoh M, Ikawa M, Tanaka KF, Ikegaya Y, et al. (2021) Astrocytic cAMP modulates memory via synaptic plasticity. Proc Natl Acad Sci USA 118(3).\u00a0https:\/\/doi.org\/10.1073\/pnas.2016584118","DOI":"10.1073\/pnas.2016584118"},{"issue":"5","key":"4067_CR106","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.cell.2012.06.052","volume":"150","author":"X Liu","year":"2012","unstructured":"Liu X, Betzenhauser MJ, Reiken S, Meli AC, Xie W, Chen BX, Arancio O, Marks AR (2012) Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell 150(5):1055\u20131067. https:\/\/doi.org\/10.1016\/j.cell.2012.06.052","journal-title":"Cell"},{"issue":"Pt 9","key":"4067_CR107","doi-asserted-by":"publisher","first-page":"2697","DOI":"10.1093\/brain\/awt188","volume":"136","author":"JB Toledo","year":"2013","unstructured":"Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA et al (2013) Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer\u2019s Coordinating Centre. Brain 136(Pt 9):2697\u20132706. https:\/\/doi.org\/10.1093\/brain\/awt188","journal-title":"Brain"},{"key":"4067_CR108","doi-asserted-by":"publisher","unstructured":"Radeva MY, Waschke J (2018) Mind the gap: mechanisms regulating the endothelial barrier. Acta Physiol (Oxf) 222(1) https:\/\/doi.org\/10.1111\/apha.12860","DOI":"10.1111\/apha.12860"},{"key":"4067_CR109","doi-asserted-by":"publisher","unstructured":"Vi\u00f1a D, Seoane N, Vasquez EC, Campos-Toimil M (2021) cAMP compartmentalization in cerebrovascular endothelial cells: new therapeutic opportunities in Alzheimer\u2019s disease. Cells 10(8).\u00a0https:\/\/doi.org\/10.3390\/cells10081951","DOI":"10.3390\/cells10081951"},{"issue":"10","key":"4067_CR110","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.1093\/cercor\/bht136","volume":"24","author":"KH Lauritzen","year":"2014","unstructured":"Lauritzen KH, Morland C, Puchades M, Holm-Hansen S, Hagelin EM, Lauritzen F, Attramadal H, Storm-Mathisen J et al (2014) Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. Cereb Cortex 24(10):2784\u20132795. https:\/\/doi.org\/10.1093\/cercor\/bht136","journal-title":"Cereb Cortex"},{"issue":"2","key":"4067_CR111","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41577-019-0259-8","volume":"20","author":"LB Ivashkiv","year":"2020","unstructured":"Ivashkiv LB (2020) The hypoxia-lactate axis tempers inflammation. Nat Rev Immunol 20(2):85\u201386. https:\/\/doi.org\/10.1038\/s41577-019-0259-8","journal-title":"Nat Rev Immunol"},{"issue":"8","key":"4067_CR112","doi-asserted-by":"publisher","first-page":"e71721","DOI":"10.1371\/journal.pone.0071721","volume":"8","author":"L Bozzo","year":"2013","unstructured":"Bozzo L, Puyal J, Chatton JY (2013) Lactate modulates the activity of primary cortical neurons through a receptor-mediated pathway. PLoS ONE 8(8):e71721. https:\/\/doi.org\/10.1371\/journal.pone.0071721","journal-title":"PLoS ONE"},{"issue":"23","key":"4067_CR113","doi-asserted-by":"publisher","first-page":"4422","DOI":"10.1523\/jneurosci.2092-18.2019","volume":"39","author":"AH de Castro","year":"2019","unstructured":"de Castro AH, Briquet M, Schmuziger C, Restivo L, Puyal J, Rosenberg N, Rocher AB, Offermanns S et al (2019) The lactate receptor HCAR1 modulates neuronal network activity through the activation of G(\u03b1) and G(\u03b2\u03b3) subunits. J Neurosci 39(23):4422\u20134433. https:\/\/doi.org\/10.1523\/jneurosci.2092-18.2019","journal-title":"J Neurosci"},{"key":"4067_CR114","doi-asserted-by":"publisher","first-page":"108609","DOI":"10.1016\/j.neuropharm.2021.108609","volume":"196","author":"SA Booker","year":"2021","unstructured":"Booker SA, Wyllie DJA (2021) NMDA receptor function in inhibitory neurons. Neuropharmacology 196:108609. https:\/\/doi.org\/10.1016\/j.neuropharm.2021.108609","journal-title":"Neuropharmacology"},{"issue":"6","key":"4067_CR115","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/nrn3504","volume":"14","author":"P Paoletti","year":"2013","unstructured":"Paoletti P, Bellone C, Zhou Q (2013) NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease. Nat Rev Neurosci 14(6):383\u2013400. https:\/\/doi.org\/10.1038\/nrn3504","journal-title":"Nat Rev Neurosci"},{"issue":"5","key":"4067_CR116","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/j.neuint.2004.03.007","volume":"45","author":"MR Hynd","year":"2004","unstructured":"Hynd MR, Scott HL, Dodd PR (2004) Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer\u2019s disease. Neurochem Int 45(5):583\u2013595. https:\/\/doi.org\/10.1016\/j.neuint.2004.03.007","journal-title":"Neurochem Int"},{"issue":"9","key":"4067_CR117","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","volume":"31","author":"I Bezprozvanny","year":"2008","unstructured":"Bezprozvanny I, Mattson MP (2008) Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease. Trends Neurosci 31(9):454\u2013463. https:\/\/doi.org\/10.1016\/j.tins.2008.06.005","journal-title":"Trends Neurosci"},{"issue":"11","key":"4067_CR118","doi-asserted-by":"publisher","first-page":"e0242309","DOI":"10.1371\/journal.pone.0242309","volume":"15","author":"G Herrera-L\u00f3pez","year":"2020","unstructured":"Herrera-L\u00f3pez G, Griego E, Galv\u00e1n EJ (2020) Lactate induces synapse-specific potentiation on CA3 pyramidal cells of rat hippocampus. PLoS ONE 15(11):e0242309. https:\/\/doi.org\/10.1371\/journal.pone.0242309","journal-title":"PLoS ONE"},{"issue":"7","key":"4067_CR119","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1038\/jcbfm.2015.77","volume":"35","author":"V Mosienko","year":"2015","unstructured":"Mosienko V, Teschemacher AG, Kasparov S (2015) Is L-lactate a novel signaling molecule in the brain? J Cereb Blood Flow Metab 35(7):1069\u20131075. https:\/\/doi.org\/10.1038\/jcbfm.2015.77","journal-title":"J Cereb Blood Flow Metab"},{"issue":"6","key":"4067_CR120","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.stem.2019.09.009","volume":"25","author":"J Wang","year":"2019","unstructured":"Wang J, Cui Y, Yu Z, Wang W, Cheng X, Ji W, Guo S, Zhou Q et al (2019) Brain endothelial cells maintain lactate homeostasis and control adult hippocampal neurogenesis. Cell Stem Cell 25(6):754-767.e759. https:\/\/doi.org\/10.1016\/j.stem.2019.09.009","journal-title":"Cell Stem Cell"},{"key":"4067_CR121","doi-asserted-by":"publisher","first-page":"10","DOI":"10.3389\/fnint.2016.00010","volume":"10","author":"MQ Steinman","year":"2016","unstructured":"Steinman MQ, Gao V, Alberini CM (2016) The role of lactate-mediated metabolic coupling between astrocytes and neurons in long-term memory formation. Front Integr Neurosci 10:10. https:\/\/doi.org\/10.3389\/fnint.2016.00010","journal-title":"Front Integr Neurosci"},{"key":"4067_CR122","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s42003-019-0495-2","volume":"2","author":"G Descalzi","year":"2019","unstructured":"Descalzi G, Gao V, Steinman MQ, Suzuki A, Alberini CM (2019) Lactate from astrocytes fuels learning-induced mRNA translation in excitatory and inhibitory neurons. Commun Biol 2:247. https:\/\/doi.org\/10.1038\/s42003-019-0495-2","journal-title":"Commun Biol"},{"issue":"2","key":"4067_CR123","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1002\/ar.23969","volume":"302","author":"WT Lu","year":"2019","unstructured":"Lu WT, Sun SQ, Li Y, Xu SY, Gan SW, Xu J, Qiu GP, Zhuo F et al (2019) Curcumin ameliorates memory deficits by enhancing lactate content and MCT2 expression in APP\/PS1 transgenic mouse model of Alzheimer\u2019s disease. Anat Rec (Hoboken) 302(2):332\u2013338. https:\/\/doi.org\/10.1002\/ar.23969","journal-title":"Anat Rec (Hoboken)"},{"issue":"11","key":"4067_CR124","doi-asserted-by":"publisher","first-page":"2040","DOI":"10.1007\/s00259-016-3417-2","volume":"43","author":"C Liguori","year":"2016","unstructured":"Liguori C, Chiaravalloti A, Sancesario G, Stefani A, Sancesario GM, Mercuri NB, Schillaci O, Pierantozzi M (2016) Cerebrospinal fluid lactate levels and brain [18F]FDG PET hypometabolism within the default mode network in Alzheimer\u2019s disease. Eur J Nucl Med Mol Imaging 43(11):2040\u20132049. https:\/\/doi.org\/10.1007\/s00259-016-3417-2","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"4067_CR125","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuro.2019.11.006","volume":"76","author":"P Hong","year":"2020","unstructured":"Hong P, Zhang X, Gao S, Wang P (2020) Role of monocarboxylate transporter 4 in Alzheimer disease. Neurotoxicology 76:191\u2013199. https:\/\/doi.org\/10.1016\/j.neuro.2019.11.006","journal-title":"Neurotoxicology"},{"issue":"13","key":"4067_CR126","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1523\/jneurosci.1661-18.2019","volume":"39","author":"L El Hayek","year":"2019","unstructured":"El Hayek L, Khalifeh M, Zibara V, Abi Assaad R, Emmanuel N, Karnib N, El-Ghandour R, Nasrallah P et al (2019) Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF). J Neurosci 39(13):2369\u20132382. https:\/\/doi.org\/10.1523\/jneurosci.1661-18.2019","journal-title":"J Neurosci"},{"key":"4067_CR127","doi-asserted-by":"publisher","unstructured":"Veloz Castillo MF, Magistretti PJ, Cal\u00ec C (2021) L-lactate: food for thoughts, memory and behavior. Metabolites 11(8).\u00a0https:\/\/doi.org\/10.3390\/metabo11080548","DOI":"10.3390\/metabo11080548"},{"issue":"3","key":"4067_CR128","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1007\/s00125-016-4164-4","volume":"60","author":"T Shima","year":"2017","unstructured":"Shima T, Matsui T, Jesmin S, Okamoto M, Soya M, Inoue K, Liu YF, Torres-Aleman I et al (2017) Moderate exercise ameliorates dysregulated hippocampal glycometabolism and memory function in a rat model of type 2 diabetes. Diabetologia 60(3):597\u2013606. https:\/\/doi.org\/10.1007\/s00125-016-4164-4","journal-title":"Diabetologia"},{"issue":"11","key":"4067_CR129","doi-asserted-by":"publisher","first-page":"1780","DOI":"10.1038\/jcbfm.2009.97","volume":"29","author":"C Berthet","year":"2009","unstructured":"Berthet C, Lei H, Thevenet J, Gruetter R, Magistretti PJ, Hirt L (2009) Neuroprotective role of lactate after cerebral ischemia. J Cereb Blood Flow Metab 29(11):1780\u20131789. https:\/\/doi.org\/10.1038\/jcbfm.2009.97","journal-title":"J Cereb Blood Flow Metab"},{"issue":"10","key":"4067_CR130","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1038\/jcbfm.2015.115","volume":"35","author":"X Castillo","year":"2015","unstructured":"Castillo X, Rosafio K, Wyss MT, Drandarov K, Buck A, Pellerin L, Weber B, Hirt L (2015) A probable dual mode of action for both L- and D-lactate neuroprotection in cerebral ischemia. J Cereb Blood Flow Metab 35(10):1561\u20131569. https:\/\/doi.org\/10.1038\/jcbfm.2015.115","journal-title":"J Cereb Blood Flow Metab"},{"key":"4067_CR131","doi-asserted-by":"publisher","unstructured":"Kennedy L, Glesaaen ER, Palibrk V, Pannone M, Wang W, Al-Jabri A, Suganthan R, Meyer N, et al (2022) Lactate receptor HCAR1 regulates neurogenesis and microglia activation after neonatal hypoxia-ischemia. Elife 11.\u00a0https:\/\/doi.org\/10.7554\/eLife.76451","DOI":"10.7554\/eLife.76451"},{"issue":"6","key":"4067_CR132","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1007\/s10072-015-2087-3","volume":"36","author":"W Lu","year":"2015","unstructured":"Lu W, Huang J, Sun S, Huang S, Gan S, Xu J, Yang M, Xu S et al (2015) Changes in lactate content and monocarboxylate transporter 2 expression in A\u03b225-35-treated rat model of Alzheimer\u2019s disease. Neurol Sci 36(6):871\u2013876. https:\/\/doi.org\/10.1007\/s10072-015-2087-3","journal-title":"Neurol Sci"},{"issue":"12","key":"4067_CR133","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1093\/jnen\/nly102","volume":"77","author":"M Zhang","year":"2018","unstructured":"Zhang M, Cheng X, Dang R, Zhang W, Zhang J, Yao Z (2018) Lactate deficit in an alzheimer disease mouse model: the relationship with neuronal damage. J Neuropathol Exp Neurol 77(12):1163\u20131176. https:\/\/doi.org\/10.1093\/jnen\/nly102","journal-title":"J Neuropathol Exp Neurol"},{"key":"4067_CR134","doi-asserted-by":"publisher","first-page":"800901","DOI":"10.3389\/fnut.2022.800901","volume":"9","author":"M Cai","year":"2022","unstructured":"Cai M, Wang H, Song H, Yang R, Wang L, Xue X, Sun W, Hu J (2022) Lactate is answerable for brain function and treating brain diseases: energy substrates and signal molecule. Front Nutr 9:800901. https:\/\/doi.org\/10.3389\/fnut.2022.800901","journal-title":"Front Nutr"},{"issue":"5","key":"4067_CR135","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000022031","volume":"44","author":"N Redjems-Bennani","year":"1998","unstructured":"Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gu\u00e9ant JL (1998) Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology 44(5):300\u2013304. https:\/\/doi.org\/10.1159\/000022031","journal-title":"Gerontology"},{"issue":"4","key":"4067_CR136","doi-asserted-by":"publisher","first-page":"884s","DOI":"10.3945\/ajcn.110.001917","volume":"93","author":"PJ Fernandez-Marcos","year":"2011","unstructured":"Fernandez-Marcos PJ, Auwerx J (2011) Regulation of PGC-1\u03b1, a nodal regulator of mitochondrial biogenesis. Am J Clin Nutr 93(4):884s\u20138890. https:\/\/doi.org\/10.3945\/ajcn.110.001917","journal-title":"Am J Clin Nutr"},{"key":"4067_CR137","doi-asserted-by":"publisher","unstructured":"E L, Lu J, Selfridge JE, Burns JM, Swerdlow RH (2013) Lactate administration reproduces specific brain and liver exercise-related changes. J Neurochem 127(1):91\u2013100.\u00a0https:\/\/doi.org\/10.1111\/jnc.12394","DOI":"10.1111\/jnc.12394"},{"issue":"3","key":"4067_CR138","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1001\/archneur.58.3.498","volume":"58","author":"D Laurin","year":"2001","unstructured":"Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K (2001) Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58(3):498\u2013504. https:\/\/doi.org\/10.1001\/archneur.58.3.498","journal-title":"Arch Neurol"},{"issue":"5","key":"4067_CR139","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.jshs.2020.01.004","volume":"9","author":"A De la Rosa","year":"2020","unstructured":"De la Rosa A, Olaso-Gonzalez G, Arc-Chagnaud C, Millan F, Salvador-Pascual A, Garcia-Lucerga C, Blasco-Lafarga C, Garcia-Dominguez E et al (2020) Physical exercise in the prevention and treatment of Alzheimer\u2019s disease. J Sport Health Sci 9(5):394\u2013404. https:\/\/doi.org\/10.1016\/j.jshs.2020.01.004","journal-title":"J Sport Health Sci"},{"issue":"9838","key":"4067_CR140","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s0140-6736(12)61031-9","volume":"380","author":"IM Lee","year":"2012","unstructured":"Lee IM, Shiroma EJ, Lobelo F, Puska P, Blair SN, Katzmarzyk PT (2012) Effect of physical inactivity on major non-communicable diseases worldwide: an analysis of burden of disease and life expectancy. Lancet 380(9838):219\u2013229. https:\/\/doi.org\/10.1016\/s0140-6736(12)61031-9","journal-title":"Lancet"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04067-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04067-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04067-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T09:22:55Z","timestamp":1726824175000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04067-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":140,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4067"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04067-x","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,1]]},"assertion":[{"value":"22 September 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Not applicable.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}