{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T08:03:35Z","timestamp":1793261015418,"version":"4.5.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T00:00:00Z","timestamp":1711065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81271025"],"award-info":[{"award-number":["No. 81271025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81860170"],"award-info":[{"award-number":["No. 81860170"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s12035-024-04105-8","type":"journal-article","created":{"date-parts":[[2024,3,22]],"date-time":"2024-03-22T09:02:31Z","timestamp":1711098151000},"page":"8454-8466","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Resveratrol Ameliorates Retinal Ischemia-Reperfusion Injury by Modulating the NLRP3 Inflammasome and Keap1\/Nrf2\/HO-1 Signaling Pathway"],"prefix":"10.1007","volume":"61","author":[{"given":"Jiazhen","family":"Feng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaibao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiji","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5534-1951","authenticated-orcid":false,"given":"Yiqiao","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"issue":"13","key":"4105_CR1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.3238\/arztebl.2020.0225","volume":"117","author":"AK Schuster","year":"2020","unstructured":"Schuster AK, Erb C, Hoffmann EM, Dietlein T, Pfeiffer N (2020) The diagnosis and treatment of glaucoma. Dtsch Arztebl Int 117(13):225\u2013234. https:\/\/doi.org\/10.3238\/arztebl.2020.0225","journal-title":"Dtsch Arztebl Int"},{"issue":"3","key":"4105_CR2","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","volume":"105","author":"JM Kang","year":"2021","unstructured":"Kang JM, Tanna AP (2021) Glaucoma. Med Clin North Am 105(3):493\u2013510. https:\/\/doi.org\/10.1016\/j.mcna.2021.01.004","journal-title":"Med Clin North Am"},{"issue":"2","key":"4105_CR3","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1001\/jama.2020.21899","volume":"325","author":"JD Stein","year":"2021","unstructured":"Stein JD, Khawaja AP, Weizer JS (2021) Glaucoma in adults-screening, diagnosis, and management: a review. JAMA 325(2):164\u2013174. https:\/\/doi.org\/10.1001\/jama.2020.21899","journal-title":"JAMA"},{"issue":"9","key":"4105_CR4","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","volume":"18","author":"Y Huang","year":"2021","unstructured":"Huang Y, Xu W, Zhou R (2021) NLRP3 inflammasome activation and cell death. Cell Mol Immunol 18(9):2114\u20132127. https:\/\/doi.org\/10.1038\/s41423-021-00740-6","journal-title":"Cell Mol Immunol"},{"key":"4105_CR5","doi-asserted-by":"publisher","first-page":"100889","DOI":"10.1016\/j.mam.2020.100889","volume":"76","author":"L Wang","year":"2020","unstructured":"Wang L, Hauenstein AV (2020) The NLRP3 inflammasome: mechanism of action, role in disease and therapies. Mol Aspects Med 76:100889. https:\/\/doi.org\/10.1016\/j.mam.2020.100889","journal-title":"Mol Aspects Med"},{"key":"4105_CR6","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.2147\/JIR.S350109","volume":"15","author":"M Wang","year":"2022","unstructured":"Wang M, Pan W, Xu Y, Zhang J, Wan J, Jiang H (2022) Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases. J Inflamm Res 15:3083\u20133094. https:\/\/doi.org\/10.2147\/JIR.S350109","journal-title":"J Inflamm Res"},{"key":"4105_CR7","doi-asserted-by":"publisher","first-page":"e934255","DOI":"10.12659\/MSM.934255","volume":"28","author":"S Shen","year":"2022","unstructured":"Shen S, Wang Z, Sun H, Ma L (2022) Role of NLRP3 inflammasome in myocardial ischemia-reperfusion injury and ventricular remodeling. Med Sci Monit 28:e934255. https:\/\/doi.org\/10.12659\/MSM.934255","journal-title":"Med Sci Monit"},{"key":"4105_CR8","doi-asserted-by":"publisher","unstructured":"8, Minutoli L, Puzzolo D, Rinaldi M, Irrera N, Marini H, Arcoraci V, Bitto A, Crea G et al (2016) ROS-mediated NLRP3 inflammasome activation in brain, heart, kidney, and testis ischemia\/reperfusion injury. Oxid Med Cell Longev 2016:2183026. https:\/\/doi.org\/10.1155\/2016\/2183026","DOI":"10.1155\/2016\/2183026"},{"issue":"4","key":"4105_CR9","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/nrcardio.2017.161","volume":"15","author":"S Toldo","year":"2018","unstructured":"Toldo S, Abbate A (2018) The NLRP3 inflammasome in acute myocardial infarction. Nat Rev Cardiol 15(4):203\u2013214. https:\/\/doi.org\/10.1038\/nrcardio.2017.161","journal-title":"Nat Rev Cardiol"},{"key":"4105_CR10","doi-asserted-by":"publisher","first-page":"120111","DOI":"10.1016\/j.lfs.2021.120111","volume":"291","author":"AV Ulasov","year":"2022","unstructured":"Ulasov AV, Rosenkranz AA, Georgiev GP, Sobolev AS (2022) Nrf2\/Keap1\/ARE signaling: towards specific regulation. Life Sci 291:120111. https:\/\/doi.org\/10.1016\/j.lfs.2021.120111","journal-title":"Life Sci"},{"key":"4105_CR11","doi-asserted-by":"publisher","unstructured":"Saha S, Buttari B, Panieri E, Profumo E, Saso L (2020) An overview of Nrf2 signaling pathway and its role in inflammation. Molecules 25(22). https:\/\/doi.org\/10.3390\/molecules25225474","DOI":"10.3390\/molecules25225474"},{"issue":"18","key":"4105_CR12","doi-asserted-by":"publisher","first-page":"5463","DOI":"10.1111\/febs.16336","volume":"289","author":"GBR Panisello-Rosell\u00f3","year":"2022","unstructured":"Panisello-Rosell\u00f3 GBR, Sanchez-Nuno A, Alva S, Rosell\u00f3-Catafau N, Carbonell J T (2022) Nrf2 and oxidative stress in liver ischemia\/reperfusion injury. Febs J 289(18):5463\u20135479. https:\/\/doi.org\/10.1111\/febs.16336","journal-title":"Febs J"},{"key":"4105_CR13","doi-asserted-by":"publisher","unstructured":"Yu C, Xiao JH (2021) The Keap1-Nrf2 system: a mediator between oxidative stress and aging. Oxid Med Cell Longev 2021:6635460. https:\/\/doi.org\/10.1155\/2021\/6635460","DOI":"10.1155\/2021\/6635460"},{"issue":"17","key":"4105_CR14","doi-asserted-by":"publisher","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","volume":"73","author":"A Loboda","year":"2016","unstructured":"Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J (2016) Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism. Cell Mol Life Sci 73(17):3221\u20133247. https:\/\/doi.org\/10.1007\/s00018-016-2223-0","journal-title":"Cell Mol Life Sci"},{"key":"4105_CR15","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.jare.2021.06.023","volume":"34","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Liu J, Duan H, Li R, Peng W, Wu C (2021) Activation of Nrf2\/HO-1 signaling: an important molecular mechanism of herbal medicine in the treatment of atherosclerosis via the protection of vascular endothelial cells from oxidative stress. J Adv Res 34:43\u201363. https:\/\/doi.org\/10.1016\/j.jare.2021.06.023","journal-title":"J Adv Res"},{"key":"4105_CR16","doi-asserted-by":"publisher","first-page":"102134","DOI":"10.1016\/j.redox.2021.102134","volume":"47","author":"C Zhang","year":"2021","unstructured":"Zhang C, Zhao M, Wang B, Su Z, Guo B, Qin L, Zhang W, Zheng R (2021) The Nrf2-NLRP3-caspase-1 axis mediates the neuroprotective effects of celastrol in Parkinson\u2019s disease. Redox Biol 47:102134. https:\/\/doi.org\/10.1016\/j.redox.2021.102134","journal-title":"Redox Biol"},{"issue":"1","key":"4105_CR17","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1186\/s12974-020-01836-y","volume":"17","author":"H Bian","year":"2020","unstructured":"Bian H, Wang G, Huang J, Liang L, Zheng Y, Wei Y, Wang H, Xiao L et al (2020) Dihydrolipoic acid protects against lipopolysaccharide-induced behavioral deficits and neuroinflammation via regulation of Nrf2\/HO-1\/NLRP3 signaling in rat. J Neuroinflammation 17(1):166. https:\/\/doi.org\/10.1186\/s12974-020-01836-y","journal-title":"J Neuroinflammation"},{"issue":"21","key":"4105_CR18","doi-asserted-by":"publisher","first-page":"9983","DOI":"10.1111\/jcmm.16871","volume":"25","author":"Y Wu","year":"2021","unstructured":"Wu Y, Qiu G, Zhang H, Zhu L, Cheng G, Wang Y, Li Y, Wu W (2021) Dexmedetomidine alleviates hepatic ischaemia-reperfusion injury via the PI3K\/AKT\/Nrf2-NLRP3 pathway. J Cell Mol Med 25(21):9983\u20139994. https:\/\/doi.org\/10.1111\/jcmm.16871","journal-title":"J Cell Mol Med"},{"key":"4105_CR19","doi-asserted-by":"publisher","first-page":"9925561","DOI":"10.1155\/2021\/9925561","volume":"2021","author":"L Xiao","year":"2021","unstructured":"Xiao L, Dai Z, Tang W, Liu C, Tang B (2021) Astragaloside IV alleviates cerebral ischemia-reperfusion injury through NLRP3 inflammasome-mediated pyroptosis inhibition via activating Nrf2. Oxid Med Cell Longev 2021:9925561. https:\/\/doi.org\/10.1155\/2021\/9925561","journal-title":"Oxid Med Cell Longev"},{"issue":"2","key":"4105_CR20","doi-asserted-by":"publisher","first-page":"861","DOI":"10.7150\/thno.48436","volume":"11","author":"Y Cheng","year":"2021","unstructured":"Cheng Y, Cheng L, Gao X, Chen S, Wu P, Wang C, Liu Z (2021) Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics 11(2):861\u2013877. https:\/\/doi.org\/10.7150\/thno.48436","journal-title":"Theranostics"},{"issue":"9","key":"4105_CR21","doi-asserted-by":"publisher","first-page":"5466","DOI":"10.1167\/iovs.14-14380","volume":"55","author":"Y Qi","year":"2014","unstructured":"Qi Y, Zhao M, Bai Y, Huang L, Yu W, Bian Z, Zhao M, Li X (2014) Retinal ischemia\/reperfusion injury is mediated by toll-like receptor 4 activation of NLRP3 inflammasomes. Invest Ophthalmol Vis Sci 55(9):5466\u20135475. https:\/\/doi.org\/10.1167\/iovs.14-14380","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"4105_CR22","doi-asserted-by":"publisher","first-page":"644219","DOI":"10.3389\/fphar.2021.644219","volume":"12","author":"CF Su","year":"2021","unstructured":"Su CF, Jiang L, Zhang XW, Iyaswamy A, Li M (2021) Resveratrol in rodent models of Parkinson\u2019s disease: a systematic review of experimental studies. Front Pharmacol 12:644219. https:\/\/doi.org\/10.3389\/fphar.2021.644219","journal-title":"Front Pharmacol"},{"issue":"1","key":"4105_CR23","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/iwj.13601","volume":"19","author":"A Hecker","year":"2022","unstructured":"Hecker A, Schellnegger M, Hofmann E, Luze H, Nischwitz SP, Kamolz LP, Kotzbeck P (2022) The impact of resveratrol on skin wound healing, scarring, and aging. Int Wound J 19(1):9\u201328. https:\/\/doi.org\/10.1111\/iwj.13601","journal-title":"Int Wound J"},{"key":"4105_CR24","doi-asserted-by":"publisher","first-page":"101199","DOI":"10.1016\/j.arr.2020.101199","volume":"65","author":"F Khorshidi","year":"2021","unstructured":"Khorshidi F, Poljak A, Liu Y, Lo JW, Crawford JD, Sachdev PS (2021) Resveratrol: a miracle drug in neuropsychiatry or a cognitive enhancer for mice only? A systematic review and meta-analysis. Ageing Res Rev 65:101199. https:\/\/doi.org\/10.1016\/j.arr.2020.101199","journal-title":"Ageing Res Rev"},{"key":"4105_CR25","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1007\/978-3-030-64872-5_13","volume":"1308","author":"A Mahdavi","year":"2021","unstructured":"Mahdavi A, Bagherniya M, Mirenayat MS, Atkin SL, Sahebkar A (2021) Medicinal plants and phytochemicals regulating insulin resistance and glucose homeostasis in type 2 diabetic patients: a clinical review. Adv Exp Med Biol 1308:161\u2013183. https:\/\/doi.org\/10.1007\/978-3-030-64872-5_13","journal-title":"Adv Exp Med Biol"},{"key":"4105_CR26","doi-asserted-by":"publisher","first-page":"117362","DOI":"10.1016\/j.lfs.2020.117362","volume":"245","author":"ZM Sun","year":"2020","unstructured":"Sun ZM, Guan P, Luo LF, Qin LY, Wang N, Zhao YS, Ji ES (2020) Resveratrol protects against CIH-induced myocardial injury by targeting Nrf2 and blocking NLRP3 inflammasome activation. Life Sci 245:117362. https:\/\/doi.org\/10.1016\/j.lfs.2020.117362","journal-title":"Life Sci"},{"key":"4105_CR27","doi-asserted-by":"publisher","first-page":"108683","DOI":"10.1016\/j.exer.2021.108683","volume":"209","author":"K Ji","year":"2021","unstructured":"Ji K, Li Z, Lei Y, Xu W, Ouyang L, He T, Xing Y (2021) Resveratrol attenuates retinal ganglion cell loss in a mouse model of retinal ischemia reperfusion injury via multiple pathways. Exp Eye Res 209:108683. https:\/\/doi.org\/10.1016\/j.exer.2021.108683","journal-title":"Exp Eye Res"},{"key":"4105_CR28","doi-asserted-by":"publisher","first-page":"102852","DOI":"10.1016\/j.redox.2023.102852","volume":"66","author":"YY Sun","year":"2023","unstructured":"Sun YY, Zhu HJ, Zhao RY, Zhou SY, Wang MQ, Yang Y, Guo ZN (2023) Remote ischemic conditioning attenuates oxidative stress and inflammation via the Nrf2\/HO-1 pathway in MCAO mice. Redox Biol 66:102852. https:\/\/doi.org\/10.1016\/j.redox.2023.102852","journal-title":"Redox Biol"},{"issue":"1","key":"4105_CR29","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1186\/s12974-023-02819-5","volume":"20","author":"J Li","year":"2023","unstructured":"Li J, Xu P, Hong Y, Xie Y, Peng M, Sun R, Guo H, Zhang X et al (2023) Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia\/reperfusion injury. J Neuroinflammation 20(1):148. https:\/\/doi.org\/10.1186\/s12974-023-02819-5","journal-title":"J Neuroinflammation"},{"key":"4105_CR30","doi-asserted-by":"publisher","first-page":"164787","DOI":"10.1016\/j.scitotenv.2023.164787","volume":"893","author":"R Hu","year":"2023","unstructured":"Hu R, Luo H, Ji Y, Wang Z, Zheng P, Ouyang H, Wang X, Wang Y et al (2023) Activation of NLRP3 signaling contributes to cadmium-induced bone defects, associated with autophagic flux obstruction. Sci Total Environ 893:164787. https:\/\/doi.org\/10.1016\/j.scitotenv.2023.164787","journal-title":"Sci Total Environ"},{"key":"4105_CR31","doi-asserted-by":"publisher","first-page":"108281","DOI":"10.1016\/j.exer.2020.108281","volume":"201","author":"J Yang","year":"2020","unstructured":"Yang J, Yang N, Luo J, Cheng G, Zhang X, He T, Xing Y (2020) Overexpression of S100A4 protects retinal ganglion cells against retinal ischemia-reperfusion injury in mice. Exp Eye Res 201:108281. https:\/\/doi.org\/10.1016\/j.exer.2020.108281","journal-title":"Exp Eye Res"},{"key":"4105_CR32","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.bbi.2020.12.009","volume":"92","author":"M Franke","year":"2021","unstructured":"Franke M, Bieber M, Kraft P, Weber A, Stoll G, Schuhmann MK (2021) The NLRP3 inflammasome drives inflammation in ischemia\/reperfusion injury after transient middle cerebral artery occlusion in mice. Brain Behav Immun 92:223\u2013233. https:\/\/doi.org\/10.1016\/j.bbi.2020.12.009","journal-title":"Brain Behav Immun"},{"issue":"3","key":"4105_CR33","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1038\/s41419-018-0378-3","volume":"9","author":"TT Tang","year":"2018","unstructured":"Tang TT, Lv LL, Pan MM, Wen Y, Wang B, Li ZL, Wu M, Wang FM et al (2018) Hydroxychloroquine attenuates renal ischemia\/reperfusion injury by inhibiting cathepsin mediated NLRP3 inflammasome activation. Cell Death Dis 9(3):351. https:\/\/doi.org\/10.1038\/s41419-018-0378-3","journal-title":"Cell Death Dis"},{"issue":"5","key":"4105_CR34","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/s41419-022-04911-9","volume":"13","author":"Q Qin","year":"2022","unstructured":"Qin Q, Yu N, Gu Y, Ke W, Zhang Q, Liu X, Wang K, Chen M (2022) Inhibiting multiple forms of cell death optimizes ganglion cells survival after retinal ischemia reperfusion injury. Cell Death Dis 13(5):507. https:\/\/doi.org\/10.1038\/s41419-022-04911-9","journal-title":"Cell Death Dis"},{"issue":"1","key":"4105_CR35","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1038\/s41392-022-00955-7","volume":"7","author":"P Kong","year":"2022","unstructured":"Kong P, Cui ZY, Huang XF, Zhang DD, Guo RJ, Han M (2022) Inflammation and atherosclerosis: signaling pathways and therapeutic intervention. Signal Transduct Target Ther 7(1):131. https:\/\/doi.org\/10.1038\/s41392-022-00955-7","journal-title":"Signal Transduct Target Ther"},{"key":"4105_CR36","doi-asserted-by":"publisher","first-page":"101973","DOI":"10.1016\/j.redox.2021.101973","volume":"43","author":"LN Madhu","year":"2021","unstructured":"Madhu LN, Kodali M, Attaluri S, Shuai B, Melissari L, Rao X, Shetty AK (2021) Melatonin improves brain function in a model of chronic Gulf War illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus. Redox Biol 43:101973. https:\/\/doi.org\/10.1016\/j.redox.2021.101973","journal-title":"Redox Biol"},{"issue":"5","key":"4105_CR37","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","volume":"22","author":"BR Sharma","year":"2021","unstructured":"Sharma BR, Kanneganti TD (2021) NLRP3 inflammasome in cancer and metabolic diseases. Nat Immunol 22(5):550\u2013559. https:\/\/doi.org\/10.1038\/s41590-021-00886-5","journal-title":"Nat Immunol"},{"issue":"1","key":"4105_CR38","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s13024-020-00372-w","volume":"15","author":"H Chen","year":"2020","unstructured":"Chen H, Deng Y, Gan X, Li Y, Huang W, Lu L, Wei L, Su L et al (2020) NLRP12 collaborates with NLRP3 and NLRC4 to promote pyroptosis inducing ganglion cell death of acute glaucoma. Mol Neurodegener 15(1):26. https:\/\/doi.org\/10.1186\/s13024-020-00372-w","journal-title":"Mol Neurodegener"},{"issue":"1","key":"4105_CR39","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s12974-022-02626-4","volume":"19","author":"M Liu","year":"2022","unstructured":"Liu M, Li H, Yang R, Ji D, Xia X (2022) GSK872 and necrostatin-1 protect retinal ganglion cells against necroptosis through inhibition of RIP1\/RIP3\/MLKL pathway in glutamate-induced retinal excitotoxic model of glaucoma. J Neuroinflammation 19(1):262. https:\/\/doi.org\/10.1186\/s12974-022-02626-4","journal-title":"J Neuroinflammation"},{"key":"4105_CR40","doi-asserted-by":"publisher","first-page":"108595","DOI":"10.1016\/j.exer.2021.108595","volume":"208","author":"J Liu","year":"2021","unstructured":"Liu J, Zhang N, Zhang M, Yin H, Zhang X, Wang X, Wang X, Zhao Y (2021) N-acetylserotonin alleviated the expression of interleukin-1\u03b2 in retinal ischemia-reperfusion rats via the TLR4\/NF-\u03baB\/NLRP3 pathway. Exp Eye Res 208:108595. https:\/\/doi.org\/10.1016\/j.exer.2021.108595","journal-title":"Exp Eye Res"},{"key":"4105_CR41","doi-asserted-by":"publisher","first-page":"6158671","DOI":"10.1155\/2018\/6158671","volume":"2018","author":"W Zhao","year":"2018","unstructured":"Zhao W, Huang X, Han X, Hu D, Hu X, Li Y, Huang P, Yao W (2018) Resveratrol suppresses gut-derived NLRP3 inflammasome partly through stabilizing mast cells in a rat model. Mediators Inflamm 2018:6158671. https:\/\/doi.org\/10.1155\/2018\/6158671","journal-title":"Mediators Inflamm"},{"key":"4105_CR42","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1016\/j.intimp.2017.06.029","volume":"50","author":"Q He","year":"2017","unstructured":"He Q, Li Z, Wang Y, Hou Y, Li L, Zhao J (2017) Resveratrol alleviates cerebral ischemia\/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction. Int Immunopharmacol 50:208\u2013215. https:\/\/doi.org\/10.1016\/j.intimp.2017.06.029","journal-title":"Int Immunopharmacol"},{"issue":"15","key":"4105_CR43","doi-asserted-by":"publisher","first-page":"4216","DOI":"10.1111\/jcmm.17431","volume":"26","author":"H Li","year":"2022","unstructured":"Li H, Zheng F, Zhang Y, Sun J, Gao F, Shi G (2022) Resveratrol, novel application by preconditioning to attenuate myocardial ischemia\/reperfusion injury in mice through regulate AMPK pathway and autophagy level. J Cell Mol Med 26(15):4216\u20134229. https:\/\/doi.org\/10.1111\/jcmm.17431","journal-title":"J Cell Mol Med"},{"issue":"1","key":"4105_CR44","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.ccell.2018.03.022","volume":"34","author":"DLVM Rojo","year":"2018","unstructured":"Rojo DLVM, Chapman E, Zhang DD (2018) NRF2 and the hallmarks of cancer. Cancer Cell 34(1):21\u201343. https:\/\/doi.org\/10.1016\/j.ccell.2018.03.022","journal-title":"Cancer Cell"},{"issue":"43","key":"4105_CR45","doi-asserted-by":"publisher","first-page":"20667","DOI":"10.1039\/c9nr07171g","volume":"11","author":"X Qin","year":"2019","unstructured":"Qin X, Li N, Zhang M, Lin S, Zhu J, Xiao D, Cui W, Zhang T et al (2019) Tetrahedral framework nucleic acids prevent retina ischemia-reperfusion injury from oxidative stress via activating the Akt\/Nrf2 pathway. Nanoscale 11(43):20667\u201320675. https:\/\/doi.org\/10.1039\/c9nr07171g","journal-title":"Nanoscale"},{"key":"4105_CR46","doi-asserted-by":"publisher","first-page":"1511","DOI":"10.3389\/fimmu.2019.01511","volume":"10","author":"BI Arioz","year":"2019","unstructured":"Arioz BI, Tastan B, Tarakcioglu E, Tufekci KU, Olcum M, Ersoy N, Bagriyanik A, Genc K et al (2019) Melatonin attenuates LPS-induced acute depressive-like behaviors and microglial NLRP3 inflammasome activation through the SIRT1\/Nrf2 pathway. Front Immunol 10:1511. https:\/\/doi.org\/10.3389\/fimmu.2019.01511","journal-title":"Front Immunol"},{"issue":"1","key":"4105_CR47","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/s12964-019-0366-y","volume":"17","author":"H Yang","year":"2019","unstructured":"Yang H, Lv H, Li H, Ci X, Peng L (2019) Oridonin protects LPS-induced acute lung injury by modulating Nrf2-mediated oxidative stress and Nrf2-independent NLRP3 and NF-\u03baB pathways. Cell Commun Signal 17(1):62. https:\/\/doi.org\/10.1186\/s12964-019-0366-y","journal-title":"Cell Commun Signal"},{"key":"4105_CR48","doi-asserted-by":"publisher","first-page":"580593","DOI":"10.3389\/fimmu.2020.580593","volume":"11","author":"Y Lin","year":"2020","unstructured":"Lin Y, Luo T, Weng A, Huang X, Yao Y, Fu Z, Li Y, Liu A et al (2020) Gallic acid alleviates gouty arthritis by inhibiting NLRP3 inflammasome activation and pyroptosis through enhancing Nrf2 signaling. Front Immunol 11:580593. https:\/\/doi.org\/10.3389\/fimmu.2020.580593","journal-title":"Front Immunol"},{"key":"4105_CR49","doi-asserted-by":"publisher","unstructured":"Satoh T, Trudler D, Oh CK, Lipton SA (2022) Potential therapeutic use of the rosemary diterpene carnosic acid for Alzheimer\u2019s disease, Parkinson\u2019s disease, and Long-COVID through NRF2 activation to counteract the NLRP3 inflammasome. Antioxid (Basel) 11(1). https:\/\/doi.org\/10.3390\/antiox11010124","DOI":"10.3390\/antiox11010124"},{"key":"4105_CR50","doi-asserted-by":"publisher","first-page":"101093","DOI":"10.1016\/j.redox.2018.101093","volume":"21","author":"Y Dai","year":"2019","unstructured":"Dai Y, Zhang J, Xiang J, Li Y, Wu D, Xu J (2019) Calcitriol inhibits ROS-NLRP3-IL-1\u03b2 signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells. Redox Biol 21:101093. https:\/\/doi.org\/10.1016\/j.redox.2018.101093","journal-title":"Redox Biol"},{"issue":"1\u20132","key":"4105_CR51","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1007\/s11010-017-3256-x","volume":"445","author":"Q Liu","year":"2018","unstructured":"Liu Q, Zhang F, Zhang X, Cheng R, Ma JX, Yi J, Li J (2018) Fenofibrate ameliorates diabetic retinopathy by modulating Nrf2 signaling and NLRP3 inflammasome activation. Mol Cell Biochem 445(1\u20132):105\u2013115. https:\/\/doi.org\/10.1007\/s11010-017-3256-x","journal-title":"Mol Cell Biochem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04105-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04105-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04105-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T09:36:01Z","timestamp":1726824961000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04105-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,22]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["4105"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04105-8","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,22]]},"assertion":[{"value":"4 August 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was performed in line with the principles of the National Institutes of Health Guide for the Care and Use of Laboratory Animals. Approval was granted by the Ethics Committee of the Renmin Hospital of Wuhan University.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have given their consent to publish this article.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Publish"}},{"value":"All authors declare that there has no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}