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Here, we aimed to investigate the temporospatial relationships among monoamine oxidase-B, tau and amyloid-\u03b2 (A\u03b2), translocator protein, and glucose metabolism by using multitracer imaging in AD transgenic mouse models. Positron emission tomography (PET) imaging with [<jats:sup>18<\/jats:sup>F]SMBT-1 (monoamine oxidase-B), [<jats:sup>18<\/jats:sup>F]florbetapir (A\u03b2), [<jats:sup>18<\/jats:sup>F]PM-PBB3 (tau), [<jats:sup>18<\/jats:sup>F]fluorodeoxyglucose (FDG), and [<jats:sup>18<\/jats:sup>F]DPA-714 (translocator protein) was carried out in 5- and 10-month-old APP\/PS1, 11-month-old 3\u00d7Tg mice, and aged-matched wild-type mice. The brain regional referenced standard uptake value (SUVR) was computed with the cerebellum as the reference region. Immunofluorescence staining was performed on mouse brain tissue slices. [<jats:sup>18<\/jats:sup>F]SMBT-1 and [<jats:sup>18<\/jats:sup>F]florbetapir SUVRs were greater in the cortex and hippocampus of 10-month-old APP\/PS1 mice than in those of 5-month-old APP\/PS1 mice and wild-type mice. No significant difference in the regional [<jats:sup>18<\/jats:sup>F]FDG or [<jats:sup>18<\/jats:sup>F]DPA-714 SUVRs was observed in the brains of 5- or 10-month-old APP\/PS1 mice or wild-type mice. No significant difference in the SUVRs of any tracer was observed between 11-month-old 3\u00d7Tg mice and age-matched wild-type mice. A positive correlation between the SUVRs of [<jats:sup>18<\/jats:sup>F]florbetapir and [<jats:sup>18<\/jats:sup>F]DPA-714 in the cortex and hippocampus was observed among the transgenic mice. Immunostaining validated the distribution of MAO-B and limited A\u03b2 and tau pathology in 11-month-old 3\u00d7Tg mice; and A\u03b2 deposits in brain tissue from 10-month-old APP\/PS1 mice. In summary, these findings provide in vivo evidence that an increase in astrocyte [<jats:sup>18<\/jats:sup>F]SMBT-1 accompanies A\u03b2 accumulation in APP\/PS1 models of AD amyloidosis.<\/jats:p>","DOI":"10.1007\/s12035-024-04106-7","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T08:02:17Z","timestamp":1710835337000},"page":"8387-8401","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Relationship Between Reactive Astrocytes, by [18F]SMBT-1 Imaging, with Amyloid-Beta, Tau, Glucose Metabolism, and TSPO in Mouse Models of Alzheimer\u2019s Disease"],"prefix":"10.1007","volume":"61","author":[{"given":"Yanyan","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cinzia A.","family":"Maschio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuantao","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Konietzko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuangyu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Rominger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfei","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger M.","family":"Nitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0793-2113","authenticated-orcid":false,"given":"Ruiqing","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,3,19]]},"reference":[{"key":"4106_CR1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.nbd.2019.03.008","volume":"127","author":"A Adlimoghaddam","year":"2019","unstructured":"Adlimoghaddam A, Snow WM, Stortz G, Perez C, Djordjevic J, Goertzen AL, Ko JH, Albensi BC (2019) Regional hypometabolism in the 3xTg mouse model of Alzheimer\u2019s disease. 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