{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:42:45Z","timestamp":1790998965272,"version":"4.1.0"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100000096","name":"Scottish Rite Charitable Foundation of Canada","doi-asserted-by":"publisher","award":["21107"],"award-info":[{"award-number":["21107"]}],"id":[{"id":"10.13039\/501100000096","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1007\/s12035-024-04181-w","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T03:02:06Z","timestamp":1713841326000},"page":"9507-9528","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Purinergic Signalling Mediates Aberrant Excitability of Developing Neuronal Circuits in the Fmr1 Knockout Mouse Model"],"prefix":"10.1007","volume":"61","author":[{"given":"Kathryn E.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eileen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Sabbineni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliza","family":"Wiseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadeem","family":"Murtaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desmond","family":"Ahuja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Napier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karun K.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela L.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"issue":"4","key":"4181_CR1","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/S0092-8674(01)00568-2","volume":"107","author":"V Brown","year":"2001","unstructured":"Brown V, Jin P, Ceman S, Darnell JC, O\u2019Donnell WT, Tenenbaum SA, Warren ST (2001) Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107(4):477\u2013487. https:\/\/doi.org\/10.1016\/S0092-8674(01)00568-2","journal-title":"Cell"},{"issue":"2","key":"4181_CR2","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.cell.2011.06.013","volume":"146","author":"JC Darnell","year":"2011","unstructured":"Darnell JC, Van Driesche SJ, Zhang C, Hung KY, Mele A, Fraser CE, Darnell RB (2011) FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism. Cell 146(2):247\u2013261. https:\/\/doi.org\/10.1016\/j.cell.2011.06.013","journal-title":"Cell"},{"issue":"6","key":"4181_CR3","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1016\/0092-8674(91)90283-5","volume":"67","author":"YH Fu","year":"1991","unstructured":"Fu YH, Kuhl DP, Pizzuti A, Pieretti M, Sutcliffe JS, Richards S et al (1991) Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 67(6):1047\u20131058. https:\/\/doi.org\/10.1016\/0092-8674(91)90283-5","journal-title":"Cell"},{"issue":"4","key":"4181_CR4","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1016\/0092-8674(91)90125-i","volume":"66","author":"M Pieretti","year":"1991","unstructured":"Pieretti M, Zhang FP, Fu YH, Warren ST, Oostra BA, Caskey CT, Nelson DL (1991) Absence of expression of the FMR-1 gene in fragile X syndrome. Cell 66(4):817\u2013822. https:\/\/doi.org\/10.1016\/0092-8674(91)90125-i","journal-title":"Cell"},{"issue":"6","key":"4181_CR5","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1093\/hmg\/1.6.397","volume":"1","author":"JS Sutcliffe","year":"1992","unstructured":"Sutcliffe JS, Nelson DL, Zhang F, Pieretti M, Caskey CT, Saxe D, Warren ST (1992) DNA methylation represses FMR-1 transcription in fragile X syndrome. Hum Mol Genet 1(6):397\u2013400. https:\/\/doi.org\/10.1093\/hmg\/1.6.397","journal-title":"Hum Mol Genet"},{"issue":"5","key":"4181_CR6","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1016\/0092-8674(91)90397-H","volume":"65","author":"AJMH Verkerk","year":"1991","unstructured":"Verkerk AJMH, Pieretti M, Sutcliffe JS, Fu Y-H, Kuhl DPA, Pizzuti A, Warren ST (1991) Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome. Cell 65(5):905\u2013914. https:\/\/doi.org\/10.1016\/0092-8674(91)90397-H","journal-title":"Cell"},{"issue":"4","key":"4181_CR7","doi-asserted-by":"publisher","first-page":"e787","DOI":"10.1038\/tp.2016.48","volume":"6","author":"LE Ethridge","year":"2016","unstructured":"Ethridge LE, White SP, Mosconi MW, Wang J, Byerly MJ, Sweeney JA (2016) Reduced habituation of auditory evoked potentials indicate cortical hyper-excitability in fragile X syndrome. Transl Psychiatry 6(4):e787. https:\/\/doi.org\/10.1038\/tp.2016.48","journal-title":"Transl Psychiatry"},{"issue":"1","key":"4181_CR8","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s13229-017-0140-1","volume":"8","author":"LE Ethridge","year":"2017","unstructured":"Ethridge LE, White SP, Mosconi MW, Wang J, Pedapati EV, Erickson CA, Sweeney JA (2017) Neural synchronization deficits linked to cortical hyper-excitability and auditory hypersensitivity in fragile X syndrome. Mol Autism 8(1):22. https:\/\/doi.org\/10.1186\/s13229-017-0140-1","journal-title":"Mol Autism"},{"issue":"2","key":"4181_CR9","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1016\/j.biopsych.2016.08.036","volume":"82","author":"JL Hodges","year":"2017","unstructured":"Hodges JL, Yu X, Gilmore A, Bennett H, Tjia M, Perna JF, Zuo Y (2017) Astrocytic contributions to synaptic and learning abnormalities in a mouse model of fragile X syndrome. Biol Psychiatry 82(2):139\u2013149. https:\/\/doi.org\/10.1016\/j.biopsych.2016.08.036","journal-title":"Biol Psychiatry"},{"issue":"12","key":"4181_CR10","doi-asserted-by":"publisher","first-page":"4508","DOI":"10.1523\/jneurosci.5027-09.2010","volume":"30","author":"S Jacobs","year":"2010","unstructured":"Jacobs S, Doering LC (2010) Astrocytes prevent abnormal neuronal development in the fragile X mouse. J Neurosci 30(12):4508\u20134514. https:\/\/doi.org\/10.1523\/jneurosci.5027-09.2010","journal-title":"J Neurosci"},{"issue":"1","key":"4181_CR11","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.tins.2008.10.001","volume":"32","author":"MP Abbracchio","year":"2009","unstructured":"Abbracchio MP, Burnstock G, Verkhratsky A, Zimmermann H (2009) Purinergic signalling in the nervous system: an overview. Trends Neurosci 32(1):19\u201329. https:\/\/doi.org\/10.1016\/j.tins.2008.10.001","journal-title":"Trends Neurosci"},{"issue":"7","key":"4181_CR12","doi-asserted-by":"publisher","first-page":"1816","DOI":"10.1002\/glia.23997","volume":"69","author":"KE Reynolds","year":"2021","unstructured":"Reynolds KE, Wong CR, Scott AL (2021) Astrocyte-mediated purinergic signaling is upregulated in a mouse model of Fragile X syndrome. Glia 69(7):1816\u20131832. https:\/\/doi.org\/10.1002\/glia.23997","journal-title":"Glia"},{"issue":"2","key":"4181_CR13","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1016\/j.cell.2009.09.025","volume":"139","author":"C Eroglu","year":"2009","unstructured":"Eroglu C, Allen NJ, Susman MW, O\u2019Rourke NA, Park CY, Ozkan E, Barres BA (2009) Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. Cell 139(2):380\u2013392. https:\/\/doi.org\/10.1016\/j.cell.2009.09.025","journal-title":"Cell"},{"issue":"24","key":"4181_CR14","doi-asserted-by":"publisher","first-page":"9321","DOI":"10.1073\/pnas.0603146103","volume":"103","author":"MD Tran","year":"2006","unstructured":"Tran MD, Neary JT (2006) Purinergic signaling induces thrombospondin-1 expression in astrocytes. Proc Natl Acad Sci USA 103(24):9321\u20139326. https:\/\/doi.org\/10.1073\/pnas.0603146103","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"4181_CR15","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/s0006-8993(03)02363-1","volume":"971","author":"R Galvez","year":"2003","unstructured":"Galvez R, Gopal AR, Greenough WT (2003) Somatosensory cortical barrel dendritic abnormalities in a mouse model of the fragile X mental retardation syndrome. Brain Res 971(1):83\u201389. https:\/\/doi.org\/10.1016\/s0006-8993(03)02363-1","journal-title":"Brain Res"},{"key":"4181_CR16","doi-asserted-by":"publisher","first-page":"268","DOI":"10.3389\/fnmol.2017.00268","volume":"10","author":"J Wallingford","year":"2017","unstructured":"Wallingford J, Scott AL, Rodrigues K, Doering LC (2017) Altered developmental expression of the astrocyte-secreted factors Hevin and SPARC in the fragile X mouse model. Front Mol Neurosci 10:268\u2013268. https:\/\/doi.org\/10.3389\/fnmol.2017.00268","journal-title":"Front Mol Neurosci"},{"issue":"1","key":"4181_CR17","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/aur.1260","volume":"6","author":"MS Brown","year":"2013","unstructured":"Brown MS, Singel D, Hepburn S, Rojas DC (2013) Increased glutamate concentration in the auditory cortex of persons with autism and first-degree relatives: a (1)H-MRS study. Autism Res 6(1):1\u201310. https:\/\/doi.org\/10.1002\/aur.1260","journal-title":"Autism Res"},{"issue":"5","key":"4181_CR18","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1152\/jn.90752.2008","volume":"100","author":"JR Gibson","year":"2008","unstructured":"Gibson JR, Bartley AF, Hays SA, Huber KM (2008) Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome. J Neurophysiol 100(5):2615\u20132626. https:\/\/doi.org\/10.1152\/jn.90752.2008","journal-title":"J Neurophysiol"},{"key":"4181_CR19","doi-asserted-by":"crossref","unstructured":"Jacobs S, Doering LC (2009) Primary dissociated astrocyte and neuron co-culture. In L. C. Doering (Ed.), Protocols for Neural Cell Culture (Fourth Edition ed., pp. 269\u2013284). New York, NY: Humana","DOI":"10.1007\/978-1-60761-292-6_16"},{"issue":"1","key":"4181_CR20","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1186\/s13041-016-0256-9","volume":"9","author":"C Cheng","year":"2016","unstructured":"Cheng C, Lau SKM, Doering LC (2016) Astrocyte-secreted thrombospondin-1 modulates synapse and spine defects in the fragile X mouse model. Mol Brain 9(1):74. https:\/\/doi.org\/10.1186\/s13041-016-0256-9","journal-title":"Mol Brain"},{"key":"4181_CR21","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3389\/fnmol.2018.00272","volume":"11","author":"V Krasovska","year":"2018","unstructured":"Krasovska V, Doering LC (2018) Regulation of IL-6 secretion by astrocytes via TLR4 in the fragile X mouse model. Front Mol Neurosci 11:272\u2013272. https:\/\/doi.org\/10.3389\/fnmol.2018.00272","journal-title":"Front Mol Neurosci"},{"issue":"Pt B","key":"4181_CR22","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.cbi.2016.06.028","volume":"259","author":"JD Cui","year":"2016","unstructured":"Cui JD, Xu ML, Liu EYL, Dong TTX, Lin HQ, Tsim KWK, Bi CWC (2016) Expression of globular form acetylcholinesterase is not altered in P2Y1R knock-out mouse brain. Chem Biol Interact 259(Pt B):291\u2013294. https:\/\/doi.org\/10.1016\/j.cbi.2016.06.028","journal-title":"Chem Biol Interact"},{"issue":"6","key":"4181_CR23","doi-asserted-by":"publisher","first-page":"1592","DOI":"10.1016\/j.bbamem.2007.03.020","volume":"1768","author":"N D\u2019Ambrosi","year":"2007","unstructured":"D\u2019Ambrosi N, Iafrate M, Saba E, Rosa P, Volont\u00e9 C (2007) Comparative analysis of P2Y4 and P2Y6 receptor architecture in native and transfected neuronal systems. Biochim et Biophys Acta (BBA) - Biomembr 1768(6):1592\u20131599. https:\/\/doi.org\/10.1016\/j.bbamem.2007.03.020","journal-title":"Biochim et Biophys Acta (BBA) - Biomembr"},{"issue":"2","key":"4181_CR24","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00232-001-0116-z","volume":"185","author":"CL Sage","year":"2002","unstructured":"Sage CL, Marcus DC (2002) Immunolocalization of P2Y4 and P2Y2 purinergic receptors in strial marginal cells and vestibular dark cells. J Membr Biol 185(2):103\u2013115. https:\/\/doi.org\/10.1007\/s00232-001-0116-z","journal-title":"J Membr Biol"},{"issue":"7139","key":"4181_CR25","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1038\/nature05704","volume":"446","author":"S Koizumi","year":"2007","unstructured":"Koizumi S, Shigemoto-Mogami Y, Nasu-Tada K, Shinozaki Y, Ohsawa K, Tsuda M, Inoue K (2007) UDP acting at P2Y6 receptors is a mediator of microglial phagocytosis. Nature 446(7139):1091\u20131095. https:\/\/doi.org\/10.1038\/nature05704","journal-title":"Nature"},{"issue":"5","key":"4181_CR26","doi-asserted-by":"publisher","first-page":"1","DOI":"10.18637\/jss.v072.i05","volume":"72","author":"Y Kondo","year":"2016","unstructured":"Kondo Y, Salibian-Barrera M, Zamar R (2016) RSKC: an R package for a robust and sparse K-means clustering algorithm. J Stat Softw 72(5):1\u201326. https:\/\/doi.org\/10.18637\/jss.v072.i05","journal-title":"J Stat Softw"},{"key":"4181_CR27","doi-asserted-by":"publisher","first-page":"668293","DOI":"10.3389\/fnins.2021.668293","volume":"15","author":"JL Balsor","year":"2021","unstructured":"Balsor JL, Arbabi K, Singh D, Kwan R, Zaslavsky J, Jeyanesan E, Murphy KM (2021) A practical guide to sparse K-means clustering for studying molecular development of the human brain. Front Neurosci 15:668293. https:\/\/doi.org\/10.3389\/fnins.2021.668293","journal-title":"Front Neurosci"},{"key":"4181_CR28","unstructured":"Van der Maaten L, Hinton G (2008) Visualizing data using t-SNE. J Mach Learn Res 9(11)"},{"issue":"1","key":"4181_CR29","doi-asserted-by":"publisher","first-page":"5416","DOI":"10.1038\/s41467-019-13056-x","volume":"10","author":"D Kobak","year":"2019","unstructured":"Kobak D, Berens P (2019) The art of using t-SNE for single-cell transcriptomics. Nat Commun 10(1):5416. https:\/\/doi.org\/10.1038\/s41467-019-13056-x","journal-title":"Nat Commun"},{"key":"4181_CR30","doi-asserted-by":"crossref","unstructured":"Wattenberg M, Vi\u00e9gas FB, Johnson I (2016) How to Use t-SNE Effectively","DOI":"10.23915\/distill.00002"},{"key":"4181_CR31","doi-asserted-by":"publisher","unstructured":"Dent EW, Gupton SL, Gertler FB (2011) The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harb Perspect Biol 3(3). https:\/\/doi.org\/10.1101\/cshperspect.a001800","DOI":"10.1101\/cshperspect.a001800"},{"issue":"10","key":"4181_CR32","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1046\/j.1440-1681.2003.03909.x","volume":"30","author":"LN Gillespie","year":"2003","unstructured":"Gillespie LN (2003) Regulation of axonal growth and guidance by the neurotrophin family of neurotrophic factors. Clin Exp Pharmacol Physiol 30(10):724\u2013733. https:\/\/doi.org\/10.1046\/j.1440-1681.2003.03909.x","journal-title":"Clin Exp Pharmacol Physiol"},{"issue":"8","key":"4181_CR33","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1002\/dneu.20800","volume":"70","author":"BM Marsick","year":"2010","unstructured":"Marsick BM, Flynn KC, Santiago-Medina M, Bamburg JR, Letourneau PC (2010) Activation of ADF\/cofilin mediates attractive growth cone turning toward nerve growth factor and netrin-1. Dev Neurobiol 70(8):565\u2013588. https:\/\/doi.org\/10.1002\/dneu.20800","journal-title":"Dev Neurobiol"},{"issue":"6","key":"4181_CR34","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1111\/jnc.12252","volume":"125","author":"TS Peterson","year":"2013","unstructured":"Peterson TS, Thebeau CN, Ajit D, Camden JM, Woods LT, Wood WG, Weisman GA (2013) Up-regulation and activation of the P2Y(2) nucleotide receptor mediate neurite extension in IL-1\u03b2-treated mouse primary cortical neurons. J Neurochem 125(6):885\u2013896. https:\/\/doi.org\/10.1111\/jnc.12252","journal-title":"J Neurochem"},{"key":"4181_CR35","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/j.neuroscience.2005.03.050","volume":"134","author":"AM Pooler","year":"2005","unstructured":"Pooler AM, Guez DH, Benedictus R, Wurtman WJ (2005) Uridine enhances neurite outgrowth in nerve growth factor-differentiated pheochromocytoma cells. Neuroscience 134:207\u2013214","journal-title":"Neuroscience"},{"key":"4181_CR36","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.neuropharm.2015.02.001","volume":"93","author":"C Heine","year":"2015","unstructured":"Heine C, Sygnecka K, Scherf N, Grohmann M, Br\u00e4sigk A, Franke H (2015) P2Y1 receptor mediated neuronal fibre outgrowth in organotypic brain slice co-cultures. Neuropharmacology 93:252\u2013266. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.02.001","journal-title":"Neuropharmacology"},{"issue":"3","key":"4181_CR37","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1046\/j.1471-4159.2001.00453.x","volume":"78","author":"S Sanchez","year":"2001","unstructured":"Sanchez S, Sayas CL, Lim F, Diaz-Nido J, Avila J, Wandosell F (2001) The inhibition of phosphatidylinositol-3-kinase induces neurite retraction and activates GSK3. J Neurochem 78(3):468\u2013481. https:\/\/doi.org\/10.1046\/j.1471-4159.2001.00453.x","journal-title":"J Neurochem"},{"issue":"3","key":"4181_CR38","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1007\/s11302-006-9008-0","volume":"2","author":"K Van Kolen","year":"2006","unstructured":"Van Kolen K, Slegers H (2006) Integration of P2Y receptor-activated signal transduction pathways in G protein-dependent signalling networks. Purinergic Signalling 2(3):451\u2013469. https:\/\/doi.org\/10.1007\/s11302-006-9008-0","journal-title":"Purinergic Signalling"},{"issue":"3","key":"4181_CR39","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1007\/pl00000701","volume":"57","author":"S Finkbeiner","year":"2000","unstructured":"Finkbeiner S (2000) Calcium regulation of the brain-derived neurotrophic factor gene. Cell Mol Life Sci 57(3):394\u2013401. https:\/\/doi.org\/10.1007\/pl00000701","journal-title":"Cell Mol Life Sci"},{"issue":"2","key":"4181_CR40","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/(SICI)1097-4695(199908)40:2<254::AID-NEU11>3.0.CO;2-4","volume":"40","author":"SA Rabacchi","year":"1999","unstructured":"Rabacchi SA, Kruk B, Hamilton J, Carney C, Hoffman JR, Meyer SL, Baird DH (1999) BDNF and NT4\/5 promote survival and neurite outgrowth of pontocerebellar mossy fiber neurons. J Neurobiol 40(2):254\u2013269","journal-title":"J Neurobiol"},{"issue":"7","key":"4181_CR41","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1002\/glia.20374","volume":"54","author":"E Scemes","year":"2006","unstructured":"Scemes E, Giaume C (2006) Astrocyte calcium waves: what they are and what they do. Glia 54(7):716\u2013725. https:\/\/doi.org\/10.1002\/glia.20374","journal-title":"Glia"},{"issue":"6","key":"4181_CR42","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1111\/j.1601-183X.2005.00128.x","volume":"4","author":"LN Antar","year":"2005","unstructured":"Antar LN, Dictenberg JB, Plociniak M, Afroz R, Bassell GJ (2005) Localization of FMRP-associated mRNA granules and requirement of microtubules for activity-dependent trafficking in hippocampal neurons. Genes Brain Behav 4(6):350\u2013359. https:\/\/doi.org\/10.1111\/j.1601-183X.2005.00128.x","journal-title":"Genes Brain Behav"},{"issue":"6","key":"4181_CR43","doi-asserted-by":"publisher","first-page":"961","DOI":"10.1016\/S0896-6273(02)00731-6","volume":"34","author":"J Morales","year":"2002","unstructured":"Morales J, Hiesinger PR, Schroeder AJ, Kume K, Verstreken P, Jackson FR, Hassan BA (2002) Drosophila fragile X protein, DFXR, regulates neuronal morphology and function in the brain. Neuron 34(6):961\u2013972. https:\/\/doi.org\/10.1016\/S0896-6273(02)00731-6","journal-title":"Neuron"},{"issue":"20","key":"4181_CR44","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1016\/j.cub.2004.09.085","volume":"14","author":"L Pan","year":"2004","unstructured":"Pan L, Zhang YQ, Woodruff E, Broadie K (2004) The drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Curr Biol 14(20):1863\u20131870. https:\/\/doi.org\/10.1016\/j.cub.2004.09.085","journal-title":"Curr Biol"},{"key":"4181_CR45","doi-asserted-by":"publisher","first-page":"30769","DOI":"10.1038\/srep30769","volume":"6","author":"J Berzhanskaya","year":"2016","unstructured":"Berzhanskaya J, Phillips MA, Shen J, Colonnese MT (2016) Sensory hypo-excitability in a rat model of fetal development in fragile X syndrome. Sci Rep 6:30769. https:\/\/doi.org\/10.1038\/srep30769","journal-title":"Sci Rep"},{"issue":"10","key":"4181_CR46","doi-asserted-by":"publisher","first-page":"2143","DOI":"10.1111\/ejn.14660","volume":"51","author":"JD Graef","year":"2020","unstructured":"Graef JD, Wu H, Ng C, Sun C, Villegas V, Qadir D, Wallace O (2020) Partial FMRP expression is sufficient to normalize neuronal hyperactivity in fragile X neurons. Eur J Neurosci 51(10):2143\u20132157. https:\/\/doi.org\/10.1111\/ejn.14660","journal-title":"Eur J Neurosci"},{"issue":"5","key":"4181_CR47","doi-asserted-by":"publisher","first-page":"979","DOI":"10.1016\/j.cell.2018.01.012","volume":"172","author":"XS Liu","year":"2018","unstructured":"Liu XS, Wu H, Krzisch M, Wu X, Graef J, Muffat J, Jaenisch R (2018) Rescue of fragile X syndrome neurons by DNA methylation editing of the FMR1 gene. Cell 172(5):979\u2013992e976. https:\/\/doi.org\/10.1016\/j.cell.2018.01.012","journal-title":"Cell"},{"issue":"1","key":"4181_CR48","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1093\/cercor\/bhz068","volume":"30","author":"A Moskalyuk","year":"2019","unstructured":"Moskalyuk A, Van De Vijver S, Verstraelen P, De Vos WH, Kooy RF, Giugliano M (2019) Single-cell and neuronal network alterations in an in vitro model of fragile X syndrome. Cereb Cortex 30(1):31\u201346. https:\/\/doi.org\/10.1093\/cercor\/bhz068","journal-title":"Cereb Cortex"},{"issue":"7","key":"4181_CR49","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1038\/nn.3415","volume":"16","author":"JT Gon\u00e7alves","year":"2013","unstructured":"Gon\u00e7alves JT, Anstey JE, Golshani P, Portera-Cailliau C (2013) Circuit level defects in the developing neocortex of fragile X mice. Nat Neurosci 16(7):903\u2013909. https:\/\/doi.org\/10.1038\/nn.3415","journal-title":"Nat Neurosci"},{"issue":"12","key":"4181_CR50","doi-asserted-by":"publisher","first-page":"1701","DOI":"10.1038\/nn.386","volume":"17","author":"Y Zhang","year":"2014","unstructured":"Zhang Y, Bonnan A, Bony G, Ferezou I, Pietropaolo S, Ginger M, Frick A (2014) Dendritic channelopathies contribute to neocortical and sensory hyperexcitability in Fmr1(-\/y) mice. Nat Neurosci 17(12):1701\u20131709. https:\/\/doi.org\/10.1038\/nn.386","journal-title":"Nat Neurosci"},{"issue":"46","key":"4181_CR51","doi-asserted-by":"publisher","first-page":"15295","DOI":"10.1523\/jneurosci.0317-15.2015","volume":"35","author":"M Telias","year":"2015","unstructured":"Telias M, Kuznitsov-Yanovsky L, Segal M, Ben-Yosef D (2015) Functional deficiencies in fragile X neurons derived from human embryonic stem cells. J Neurosci 35(46):15295\u201315306. https:\/\/doi.org\/10.1523\/jneurosci.0317-15.2015","journal-title":"J Neurosci"},{"issue":"5","key":"4181_CR52","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/s0301-0082(03)00051-0","volume":"69","author":"L Lossi","year":"2003","unstructured":"Lossi L, Merighi A (2003) In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS. Prog Neurobiol 69(5):287\u2013312. https:\/\/doi.org\/10.1016\/s0301-0082(03)00051-0","journal-title":"Prog Neurobiol"},{"issue":"7480","key":"4181_CR53","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1038\/nature12776","volume":"504","author":"WS Chung","year":"2013","unstructured":"Chung WS, Clarke LE, Wang GX, Stafford BK, Sher A, Chakraborty C, Barres BA (2013) Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504(7480):394\u2013400. https:\/\/doi.org\/10.1038\/nature12776","journal-title":"Nature"},{"issue":"5","key":"4181_CR54","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nrn1667","volume":"6","author":"C Bagni","year":"2005","unstructured":"Bagni C, Greenough WT (2005) From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome. Nat Rev Neurosci 6(5):376\u2013387. https:\/\/doi.org\/10.1038\/nrn1667","journal-title":"Nat Rev Neurosci"},{"issue":"9","key":"4181_CR55","doi-asserted-by":"publisher","first-page":"3413","DOI":"10.1523\/jneurosci.2921-13.2014","volume":"34","author":"AB Patel","year":"2014","unstructured":"Patel AB, Loerwald KW, Huber KM, Gibson JR (2014) Postsynaptic FMRP promotes the pruning of cell-to-cell connections among pyramidal neurons in the L5A neocortical network. J Neurosci 34(9):3413\u20133418. https:\/\/doi.org\/10.1523\/jneurosci.2921-13.2014","journal-title":"J Neurosci"},{"issue":"3","key":"4181_CR56","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.neulet.2004.11.087","volume":"377","author":"A El Idrissi","year":"2005","unstructured":"El Idrissi A, Ding XH, Scalia J, Trenkner E, Brown WT, Dobkin C (2005) Decreased GABA(A) receptor expression in the seizure-prone fragile X mouse. Neurosci Lett 377(3):141\u2013146. https:\/\/doi.org\/10.1016\/j.neulet.2004.11.087","journal-title":"Neurosci Lett"},{"issue":"1","key":"4181_CR57","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/2040-2392-2-6","volume":"2","author":"SH Fatemi","year":"2011","unstructured":"Fatemi SH, Folsom TD (2011) Dysregulation of fragile X mental retardation protein and metabotropic glutamate receptor 5 in superior frontal cortex of individuals with autism: a postmortem brain study. Mol Autism 2(1):6. https:\/\/doi.org\/10.1186\/2040-2392-2-6","journal-title":"Mol Autism"},{"issue":"27","key":"4181_CR58","doi-asserted-by":"publisher","first-page":"7079","DOI":"10.1523\/jneurosci.1069-16.2016","volume":"36","author":"H Higashimori","year":"2016","unstructured":"Higashimori H, Schin CS, Chiang MS, Morel L, Shoneye TA, Nelson DL, Yang Y (2016) Selective deletion of astroglial FMRP dysregulates glutamate transporter GLT1 and contributes to fragile X syndrome phenotypes in vivo. J Neurosci 36(27):7079\u20137094. https:\/\/doi.org\/10.1523\/jneurosci.1069-16.2016","journal-title":"J Neurosci"},{"key":"4181_CR59","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.yebeh.2015.04.056","volume":"48","author":"N Soni","year":"2015","unstructured":"Soni N, Koushal P, Reddy BV, Deshmukh R, Kumar P (2015) Effect of GLT-1 modulator and P2X7 antagonists alone and in combination in the kindling model of epilepsy in rats. Epilepsy Behav 48:4\u201314. https:\/\/doi.org\/10.1016\/j.yebeh.2015.04.056","journal-title":"Epilepsy Behav"},{"key":"4181_CR60","doi-asserted-by":"publisher","first-page":"577745","DOI":"10.1016\/j.jneuroim.2021.577745","volume":"361","author":"KE Reynolds","year":"2021","unstructured":"Reynolds KE, Krasovska V, Scott AL (2021) Converging purinergic and immune signaling pathways drive IL-6 secretion by fragile X cortical astrocytes via STAT3. J Neuroimmunol 361:577745. https:\/\/doi.org\/10.1016\/j.jneuroim.2021.577745","journal-title":"J Neuroimmunol"},{"issue":"9","key":"4181_CR61","doi-asserted-by":"publisher","first-page":"1603","DOI":"10.1111\/epi.13850","volume":"58","author":"M Alves","year":"2017","unstructured":"Alves M, Gomez-Villafuertes R, Delanty N, Farrell MA, O\u2019Brien DF, Miras-Portugal MT, Engel T (2017) Expression and function of the metabotropic purinergic P2Y receptor family in experimental seizure models and patients with drug-refractory epilepsy. Epilepsia 58(9):1603\u20131614. https:\/\/doi.org\/10.1111\/epi.13850","journal-title":"Epilepsia"},{"issue":"8","key":"4181_CR62","doi-asserted-by":"publisher","first-page":"798","DOI":"10.1097\/nen.0000000000000099","volume":"73","author":"S Sukigara","year":"2014","unstructured":"Sukigara S, Dai H, Nabatame S, Otsuki T, Hanai S, Honda R, Itoh M (2014) Expression of astrocyte-related receptors in cortical dysplasia with intractable epilepsy. J Neuropathol Exp Neurol 73(8):798\u2013806. https:\/\/doi.org\/10.1097\/nen.0000000000000099","journal-title":"J Neuropathol Exp Neurol"},{"issue":"8","key":"4181_CR63","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1111\/j.1528-1157.1999.tb00824.x","volume":"40","author":"SA Musumeci","year":"1999","unstructured":"Musumeci SA, Hagerman RJ, Ferri R, Bosco P, Bernardina BD, Tassinari CA, Elia M (1999) Epilepsy and EEG findings in males with fragile X syndrome. Epilepsia 40(8):1092\u20131099. https:\/\/doi.org\/10.1111\/j.1528-1157.1999.tb00824.x","journal-title":"Epilepsia"},{"issue":"7","key":"4181_CR64","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1002\/acn3.424","volume":"4","author":"RK Naviaux","year":"2017","unstructured":"Naviaux RK, Curtis B, Li K, Naviaux JC, Bright AT, Reiner GE, Townsend J (2017) Low-dose suramin in autism spectrum disorder: a small, phase I\/II, randomized clinical trial. Ann Clin Transl Neurol 4(7):491\u2013505. https:\/\/doi.org\/10.1002\/acn3.424","journal-title":"Ann Clin Transl Neurol"},{"issue":"10","key":"4181_CR65","doi-asserted-by":"publisher","first-page":"2233","DOI":"10.1093\/cercor\/bhq296","volume":"21","author":"R-A M\u00fcller","year":"2011","unstructured":"M\u00fcller R-A, Shih P, Keehn B, Deyoe JR, Leyden KM, Shukla DK (2011) Underconnected, but how? A survey of functional connectivity MRI studies in autism spectrum disorders. Cereb Cortex 21(10):2233\u20132243. https:\/\/doi.org\/10.1093\/cercor\/bhq296","journal-title":"Cereb Cortex"},{"issue":"5","key":"4181_CR66","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1152\/jn.00421.2011","volume":"106","author":"SM Paluszkiewicz","year":"2011","unstructured":"Paluszkiewicz SM, Olmos-Serrano JL, Corbin JG, Huntsman MM (2011) Impaired inhibitory control of cortical synchronization in fragile X syndrome. J Neurophysiol 106(5):2264\u20132272. https:\/\/doi.org\/10.1152\/jn.00421.2011","journal-title":"J Neurophysiol"},{"issue":"6","key":"4181_CR67","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1093\/cercor\/bhr224","volume":"22","author":"G Testa-Silva","year":"2012","unstructured":"Testa-Silva G, Loebel A, Giugliano M, de Kock CP, Mansvelder HD, Meredith RM (2012) Hyperconnectivity and slow synapses during early development of medial prefrontal cortex in a mouse model for mental retardation and autism. Cereb Cortex 22(6):1333\u20131342. https:\/\/doi.org\/10.1093\/cercor\/bhr224","journal-title":"Cereb Cortex"},{"issue":"1","key":"4181_CR68","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1002\/aur.1494","volume":"9","author":"DR Dajani","year":"2016","unstructured":"Dajani DR, Uddin LQ (2016) Local brain connectivity across development in autism spectrum disorder: a cross-sectional investigation. Autism Res 9(1):43\u201354. https:\/\/doi.org\/10.1002\/aur.1494","journal-title":"Autism Res"},{"key":"4181_CR69","doi-asserted-by":"publisher","unstructured":"Rio C-D, C. A., Huntsman MM (2014) The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome. Front Cell Neurosci 8(245). https:\/\/doi.org\/10.3389\/fncel.2014.00245","DOI":"10.3389\/fncel.2014.00245"},{"issue":"20","key":"4181_CR70","doi-asserted-by":"publisher","first-page":"5178","DOI":"10.1523\/jneurosci.1076-08.2008","volume":"28","author":"I Bureau","year":"2008","unstructured":"Bureau I, Shepherd GMG, Svoboda K (2008) Circuit and plasticity defects in the developing somatosensory cortex of Fmr1 knock-out mice. J Neurosci 28(20):5178\u20135188. https:\/\/doi.org\/10.1523\/jneurosci.1076-08.2008","journal-title":"J Neurosci"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04181-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04181-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04181-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T07:10:59Z","timestamp":1729581059000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04181-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":70,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["4181"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04181-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"assertion":[{"value":"6 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All animal experimental protocols were authorized by the McMaster Animal Ethics Board (Animal Utilization Protocol 21-02-06), following Canadian Council on Animal Care policies.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}