{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:23:38Z","timestamp":1792783418139,"version":"4.5.0"},"reference-count":64,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["No. BK20211348"],"award-info":[{"award-number":["No. BK20211348"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Xuzhou Basic Research Program","award":["KC21030"],"award-info":[{"award-number":["KC21030"]}]},{"name":"Leadership program through open competition in Xuzhou Medical University","award":["JBGS202203"],"award-info":[{"award-number":["JBGS202203"]}]},{"name":"Postgraduate Research & Practice Innovation Program of Jiangsu Province","award":["No. KYCX21_2722"],"award-info":[{"award-number":["No. KYCX21_2722"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s12035-024-04238-w","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T06:01:57Z","timestamp":1716184917000},"page":"10629-10644","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Peroxynitrite-Triggered Carbon Monoxide Donor Improves Ischemic Stroke Outcome by Inhibiting Neuronal Apoptosis and Ferroptosis"],"prefix":"10.1007","volume":"61","author":[{"given":"Xin-Jian","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin-Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Tong","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-De","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xicun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youjun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-701X","authenticated-orcid":false,"given":"Su-Hua","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"issue":"26","key":"4238_CR1","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.1056\/NEJMc1705673","volume":"376","author":"Y Zhang","year":"2017","unstructured":"Zhang Y, Chen S, Tang W (2017) Two-year outcome after endovascular treatment for stroke. N Engl J Med 376(26):2597","journal-title":"N Engl J Med"},{"issue":"9","key":"4238_CR2","doi-asserted-by":"publisher","first-page":"2209","DOI":"10.1161\/STROKEAHA.116.014178","volume":"47","author":"T Nezu","year":"2016","unstructured":"Nezu T, Mukai T, Uemura J, Yamashita M, Kitano T, Wada Y et al (2016) Multiple infarcts are associated with long-term stroke recurrence and all-cause mortality in cryptoge nic stroke patients. Stroke 47(9):2209\u20132215","journal-title":"Stroke"},{"issue":"1","key":"4238_CR3","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1161\/STROKEAHA.115.010898","volume":"47","author":"J Salinas","year":"2016","unstructured":"Salinas J, Sprinkhuizen SM, Ackerson T, Bernhardt J, Davie C, George MG et al (2016) An international standard set of patient-centered outcome measures after stroke. Stroke. 47(1):180\u2013186","journal-title":"Stroke."},{"issue":"3-4","key":"4238_CR4","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1159\/000499112","volume":"47","author":"D Weisenburger-Lile","year":"2019","unstructured":"Weisenburger-Lile D, Blanc R, Kyheng M, Desilles JP, Labreuche J, Piotin M et al (2019) Direct admission versus secondary transfer for acute stroke patients treated with intravenous thrombo lysis and thrombectomy: insights from the endovascular treatment in ischemic stroke registry. Cerebrovasc Dis 47(3-4):112\u2013120","journal-title":"Cerebrovasc Dis"},{"issue":"7527","key":"4238_CR5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1038\/nature13909","volume":"515","author":"ET Chouchani","year":"2014","unstructured":"Chouchani ET, Pell VR, Gaude E, Aksentijevi D, Sundier SY, Robb EL et al (2014) Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS. Nature. 515(7527):431\u2013435","journal-title":"Nature."},{"issue":"10","key":"4238_CR6","doi-asserted-by":"publisher","first-page":"e1807591","DOI":"10.1002\/adma.201807591","volume":"31","author":"XC Jiang","year":"2019","unstructured":"Jiang XC, Xiang JJ, Wu HH, Zhang TY, Zhang DP, Xu QH et al (2019) Neural stem cells transfected with reactive oxygen species-responsive polyplexes for effective treatm ent of ischemic stroke. Adv Mater 31(10):e1807591","journal-title":"Adv Mater"},{"key":"4238_CR7","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","volume":"298","author":"T Kalogeris","year":"2012","unstructured":"Kalogeris T, Baines CP, Krenz M, Korthuis RJ (2012) Cell biology of ischemia\/reperfusion injury. Int Rev Cell Mol Biol 298:229\u2013317","journal-title":"Int Rev Cell Mol Biol"},{"issue":"2","key":"4238_CR8","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1007\/s00440-002-0236-0","volume":"125","author":"B Morris","year":"2003","unstructured":"Morris B (2003) The components of the wired spanning forest are recurrent. Probab Theory Relat Fields 125(2):259\u2013265","journal-title":"Probab Theory Relat Fields"},{"issue":"5","key":"4238_CR9","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","volume":"149","author":"SJ Dixon","year":"2012","unstructured":"Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell. 149(5):1060\u20131072","journal-title":"Cell."},{"issue":"11","key":"4238_CR10","doi-asserted-by":"publisher","first-page":"1520","DOI":"10.1038\/mp.2017.171","volume":"22","author":"QZ Tuo","year":"2017","unstructured":"Tuo QZ, Lei P, Jackman KA, Li XL, Xiong H, Li XL et al (2017) Tau-mediated iron export prevents ferroptotic damage after ischemic stroke. Mol Psychiatry 22(11):1520\u20131530","journal-title":"Mol Psychiatry"},{"issue":"4","key":"4238_CR11","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1007\/s10571-017-0568-z","volume":"38","author":"C Ji","year":"2018","unstructured":"Ji C, Steimle BL, Bailey DK, Kosman DJ (2018) The ferroxidase hephaestin but not amyloid precursor protein is required for ferroportin-supported iron efflux in primary hippocampal neurons. Cell Mol Neurobiol 38(4):941\u2013954","journal-title":"Cell Mol Neurobiol"},{"issue":"3","key":"4238_CR12","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1179\/016164103101201508","volume":"25","author":"N Omori","year":"2003","unstructured":"Omori N, Maruyama K, Jin G, Li F, Wang SJ, Hamakawa Y et al (2003) Targeting of post-ischemic cerebral endothelium in rat by liposomes bearing polyethylene glycol-coupled transferrin. Neurol Res 25(3):275\u2013279","journal-title":"Neurol Res"},{"key":"4238_CR13","doi-asserted-by":"publisher","first-page":"577403","DOI":"10.3389\/fncel.2020.577403","volume":"14","author":"J Liu","year":"2020","unstructured":"Liu J, Guo ZN, Yan XL, Huang S, Ren JX, Luo Y et al (2020) Crosstalk between autophagy and ferroptosis and its putative role in ischemic stroke. Front Cell Neurosci 14:577403","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"4238_CR14","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.pathophys.2016.11.002","volume":"24","author":"O Sakai","year":"2017","unstructured":"Sakai O, Yasuzawa T, Sumikawa Y, Ueta T, Imai H, Sawabe A et al (2017) Role of GPx4 in human vascular endothelial cells, and the compensatory activity of brown rice on GPx4 ablation condition. Pathophysiology 24(1):9\u201315","journal-title":"Pathophysiology"},{"issue":"2","key":"4238_CR15","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","volume":"171","author":"BR Stockwell","year":"2017","unstructured":"Stockwell BR, Friedmann Angeli JP, Bayir H, Bush AI, Conrad M, Dixon SJ et al (2017) Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease. Cell 171(2):273\u2013285","journal-title":"Cell"},{"issue":"4","key":"4238_CR16","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1007\/s11325-020-02091-4","volume":"24","author":"LD Chen","year":"2020","unstructured":"Chen LD, Wu RH, Huang YZ, Chen MX, Zeng AM, Zhuo GF et al (2020) The role of ferroptosis in chronic intermittent hypoxia-induced liver injury in rats. Sleep Breath 24(4):1767\u20131773","journal-title":"Sleep Breath"},{"issue":"11","key":"4238_CR17","doi-asserted-by":"publisher","first-page":"3273","DOI":"10.3390\/cancers12113273","volume":"12","author":"H Yang","year":"2020","unstructured":"Yang H, Zhao L, Gao Y, Yao F, Marti TM, Schmid RA et al (2020) Pharmacotranscriptomic analysis reveals novel drugs and gene networks regulating ferroptosis in cancer. Cancers (Basel) 12(11):3273","journal-title":"Cancers (Basel)"},{"issue":"7","key":"4238_CR18","doi-asserted-by":"publisher","first-page":"3052","DOI":"10.7150\/thno.54113","volume":"11","author":"X Wu","year":"2021","unstructured":"Wu X, Li Y, Zhang S, Zhou X (2021) Ferroptosis as a novel therapeutic target for cardiovascular disease. Theranostics. 11(7):3052\u20133059","journal-title":"Theranostics."},{"issue":"5","key":"4238_CR19","doi-asserted-by":"publisher","first-page":"1262","DOI":"10.1016\/j.cell.2019.03.032","volume":"177","author":"I Alim","year":"2019","unstructured":"Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E et al (2019) Selenium drives a transcriptional adaptive program to block ferroptosis and treat stroke. Cell 177(5):1262\u20131279.e1225","journal-title":"Cell"},{"issue":"1-2","key":"4238_CR20","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","volume":"156","author":"WS Yang","year":"2014","unstructured":"Yang WS, SriRamaratnam R, Welsch ME, Shimada K, Skouta R, Viswanathan VS et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell 156(1-2):317\u2013331","journal-title":"Cell"},{"issue":"8","key":"4238_CR21","doi-asserted-by":"publisher","first-page":"1364","DOI":"10.1016\/j.neuint.2012.09.014","volume":"61","author":"I Garc\u00eda-Y\u00e9benes","year":"2012","unstructured":"Garc\u00eda-Y\u00e9benes I, Sobrado M, Moraga A, Zarruk JG, Romera VG, Pradillo JM et al (2012) Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion. Neurochem Int 61(8):1364\u20131369","journal-title":"Neurochem Int"},{"key":"4238_CR22","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.tox.2015.08.009","volume":"337","author":"J Park","year":"2015","unstructured":"Park J, Lee DG, Kim B, Park SJ, Kim JH, Lee SR et al (2015) Iron overload triggers mitochondrial fragmentation via calcineurin-sensitive signals in HT-22 hippocampal neuron cells. Toxicology 337:39\u201346","journal-title":"Toxicology"},{"issue":"1","key":"4238_CR23","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1186\/s12974-018-1226-1","volume":"15","author":"J Wang","year":"2018","unstructured":"Wang J, Zhang D, Fu X, Yu L, Lu Z, Gao Y et al (2018) Carbon monoxide-releasing molecule-3 protects against ischemic stroke by suppressing neuroinflammation and alleviating blood-brain barrier disruption. J Neuroinflammation 15(1):188","journal-title":"J Neuroinflammation"},{"issue":"11","key":"4238_CR24","first-page":"C1105","volume":"304","author":"S Basuroy","year":"2013","unstructured":"Basuroy S, Leffler CW, Parfenova H (2013) CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis. Am J Phys Cell Phys 304(11):C1105\u2013C1115","journal-title":"Am J Phys Cell Phys"},{"issue":"5","key":"4238_CR25","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1021\/jacs.2c00094","volume":"144","author":"L Xing","year":"2022","unstructured":"Xing L, Wang B, Li J, Guo X, Lu X, Chen X et al (2022) A fluorogenic ONOO--triggered carbon monoxide donor for mitigating brain ischemic damage. J Am Chem Soc 144(5):2114\u20132119","journal-title":"J Am Chem Soc"},{"key":"4238_CR26","first-page":"480","volume":"28","author":"J Zhang","year":"2023","unstructured":"Zhang J, Liu L, Dong Z, Lu X, Hong W, Liu J et al (2023) An ischemic area-targeting, peroxynitrite-responsive, biomimetic carbon monoxide nanogenerator for preventing myocardial ischemia-reperfusion injury. Bioact Mater 28:480\u2013494","journal-title":"Bioact Mater"},{"issue":"8","key":"4238_CR27","doi-asserted-by":"publisher","first-page":"e202201385","DOI":"10.26508\/lsa.202201385","volume":"5","author":"S Parween","year":"2022","unstructured":"Parween S, Alawathugoda TT, Prabakaran AD, Dheen ST, Morse RH, Emerald BS et al (2022) Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis. Life Sci Alliance 5(8):e202201385","journal-title":"Life Sci Alliance"},{"issue":"5","key":"4238_CR28","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1007\/s12975-017-0598-3","volume":"9","author":"H Chen","year":"2018","unstructured":"Chen H, Guan B, Chen X, Chen X, Li C, Qiu J et al (2018) Baicalin attenuates blood-brain barrier disruption and hemorrhagic transformation and improves neurol ogical outcome in ischemic stroke rats with delayed t-PA treatment: involvement of ONOO--MMP-9 pathway. Transl Stroke Res 9(5):515\u2013529","journal-title":"Transl Stroke Res"},{"issue":"3","key":"4238_CR29","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1080\/15548627.2018.1531196","volume":"15","author":"Y Liu","year":"2019","unstructured":"Liu Y, Xue X, Zhang H, Che X, Luo J, Wang P et al (2019) Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. Autophagy 15(3):493\u2013509","journal-title":"Autophagy"},{"issue":"38","key":"4238_CR30","doi-asserted-by":"publisher","first-page":"15668","DOI":"10.1021\/ja307017b","volume":"134","author":"BW Michel","year":"2012","unstructured":"Michel BW, Lippert AR, Chang CJ (2012) A reaction-based fluorescent probe for selective imaging of carbon monoxide in living cells using a palladium-mediated carbonylation. J Am Chem Soc 134(38):15668\u201315671","journal-title":"J Am Chem Soc"},{"issue":"4","key":"4238_CR31","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1152\/physrev.1999.79.4.1431","volume":"79","author":"P Lipton","year":"1999","unstructured":"Lipton P (1999) Ischemic cell death in brain neurons. Physiol Rev 79(4):1431\u20131568","journal-title":"Physiol Rev"},{"issue":"9","key":"4238_CR32","doi-asserted-by":"publisher","first-page":"4959","DOI":"10.1073\/pnas.1916427117","volume":"117","author":"MG Naito","year":"2020","unstructured":"Naito MG, Xu D, Amin P, Lee J, Wang H, Li W et al (2020) Sequential activation of necroptosis and apoptosis cooperates to mediate vascular and neural pathology in stroke. P Natl Acad Sci USA 117(9):4959\u20134970","journal-title":"P Natl Acad Sci USA"},{"key":"4238_CR33","doi-asserted-by":"publisher","first-page":"101328","DOI":"10.1016\/j.redox.2019.101328","volume":"28","author":"G Miotto","year":"2020","unstructured":"Miotto G, Rossetto M, Di Paolo ML, Orian L, Venerando R, Roveri A et al (2020) Insight into the mechanism of ferroptosis inhibition by ferrostatin-1. Redox Biol 28:101328","journal-title":"Redox Biol"},{"issue":"1","key":"4238_CR34","doi-asserted-by":"publisher","first-page":"e0210232","DOI":"10.1371\/journal.pone.0210232","volume":"14","author":"LA Celi","year":"2019","unstructured":"Celi LA, Citi L, Ghassemi M, Pollard TJ (2019) The plos one collection on machine learning in health and biomedicine: towards open code and open data. PLoS One 14(1):e0210232","journal-title":"PLoS One"},{"issue":"2","key":"4238_CR35","doi-asserted-by":"publisher","first-page":"152","DOI":"10.4037\/ajcc2019938","volume":"28","author":"M Halm","year":"2019","unstructured":"Halm M (2019) The influence of appropriate staffing and healthy work environments on patient and nurse outcomes. Am J Crit Care 28(2):152\u2013156","journal-title":"Am J Crit Care"},{"issue":"1-2","key":"4238_CR36","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1016\/j.ijpharm.2006.07.044","volume":"327","author":"YC Kuo","year":"2006","unstructured":"Kuo YC, Chen HH (2006) Effect of nanoparticulate polybutylcyanoacrylate and methylmethacrylate-sulfopropylmethacrylate on th e permeability of zidovudine and lamivudine across the in vitro blood-brain barrier. Int J Pharm 327(1-2):160\u2013169","journal-title":"Int J Pharm"},{"issue":"2","key":"4238_CR37","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1038\/s41591-018-0297-y","volume":"25","author":"DA Nation","year":"2019","unstructured":"Nation DA, Sweeney MD, Montagne A, Sagare AP, D'Orazio LM, Pachicano M et al (2019) Blood-brain barrier breakdown is an early biomarker of human cognitive dysfunction. Nat Med 25(2):270\u2013276","journal-title":"Nat Med"},{"key":"4238_CR38","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1146\/annurev.neuro.22.1.11","volume":"22","author":"LL Rubin","year":"1999","unstructured":"Rubin LL, Staddon JM (1999) The cell biology of the blood-brain barrier. Annu Rev Neurosci 22:11\u201328","journal-title":"Annu Rev Neurosci"},{"key":"4238_CR39","doi-asserted-by":"publisher","first-page":"661955","DOI":"10.3389\/fneur.2021.661955","volume":"12","author":"E Spronk","year":"2021","unstructured":"Spronk E, Sykes G, Falcione S, Munsterman D, Joy T, Kamtchum-Tatuene J et al (2021) Hemorrhagic transformation in ischemic stroke and the role of inflammation. Front Neurol 12:661955","journal-title":"Front Neurol"},{"key":"4238_CR40","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.neuroscience.2015.03.065","volume":"297","author":"R Ding","year":"2015","unstructured":"Ding R, Feng L, He L, Chen Y, Wen P, Fu Z et al (2015) Peroxynitrite decomposition catalyst prevents matrix metalloproteinase-9 activation and neurovascular injury after hemoglobin injection into the caudate nucleus of rats. Neuroscience. 297:182\u2013193","journal-title":"Neuroscience."},{"issue":"11","key":"4238_CR41","doi-asserted-by":"publisher","first-page":"C1105","DOI":"10.1152\/ajpcell.00023.2013","volume":"304","author":"S Basuroy","year":"2013","unstructured":"Basuroy S, Leffler CW, Parfenova H (2013) CORM-A1 prevents blood-brain barrier dysfunction caused by ionotropic glutamate receptor-mediated endothelial oxidative stress and apoptosis. Am J Physiol-Cell Ph 304(11):C1105\u2013C1115","journal-title":"Am J Physiol-Cell Ph"},{"issue":"10","key":"4238_CR42","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1007\/s12264-022-00859-0","volume":"38","author":"R Mao","year":"2022","unstructured":"Mao R, Zong N, Hu Y, Chen Y, Xu Y (2022) Neuronal death mechanisms and therapeutic strategy in ischemic stroke. Neurosci Bull 38(10):1229\u20131247","journal-title":"Neurosci Bull"},{"issue":"4","key":"4238_CR43","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/s10495-008-0304-8","volume":"14","author":"J Yuan","year":"2009","unstructured":"Yuan J (2009) Neuroprotective strategies targeting apoptotic and necrotic cell death for stroke. Apoptosis. 14(4):469\u2013477","journal-title":"Apoptosis."},{"issue":"1","key":"4238_CR44","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.cmet.2020.12.007","volume":"33","author":"YP Kang","year":"2021","unstructured":"Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E et al (2021) Non-canonical glutamate-cysteine ligase activity protects against ferroptosis. Cell Metab 33(1):174\u2013189.e177","journal-title":"Cell Metab"},{"issue":"12","key":"4238_CR45","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/s41568-021-00388-4","volume":"21","author":"AJ Hoy","year":"2021","unstructured":"Hoy AJ, Nagarajan SR, Butler LM (2021) Tumour fatty acid metabolism in the context of therapy resistance and obesity. Nat Rev Cancer 21(12):753\u2013766","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"4238_CR46","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1038\/s41580-019-0195-2","volume":"21","author":"P Strzyz","year":"2020","unstructured":"Strzyz P (2020) Iron expulsion by exosomes drives ferroptosis resistance. Nat Rev Mol Cell Biol 21(1):4\u20135","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"7860","key":"4238_CR47","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1038\/s41586-021-03539-7","volume":"593","author":"C Mao","year":"2021","unstructured":"Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H et al (2021) DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer. Nature. 593(7860):586\u2013590","journal-title":"Nature."},{"key":"4238_CR48","doi-asserted-by":"publisher","first-page":"102021","DOI":"10.1016\/j.redox.2021.102021","volume":"45","author":"S Jang","year":"2021","unstructured":"Jang S, Chapa-Dubocq XR, Tyurina YY, St Croix CM, Kapralov AA, Tyurin VA et al (2021) Elucidating the contribution of mitochondrial glutathione to ferroptosis in cardiomyocytes. Redox Biol 45:102021","journal-title":"Redox Biol"},{"issue":"12","key":"4238_CR49","doi-asserted-by":"publisher","first-page":"2815","DOI":"10.1161\/STROKEAHA.118.022701","volume":"49","author":"D Gill","year":"2018","unstructured":"Gill D, Monori G, Tzoulaki I, Dehghan A (2018) Iron status and risk of stroke. Stroke 49(12):2815\u20132821","journal-title":"Stroke"},{"issue":"2","key":"4238_CR50","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1161\/STROKEAHA.112.679662","volume":"44","author":"J Kaluza","year":"2013","unstructured":"Kaluza J, Wolk A, Larsson SC (2013) Heme iron intake and risk of stroke: a prospective study of men. Stroke 44(2):334\u2013339","journal-title":"Stroke"},{"issue":"9","key":"4238_CR51","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1161\/STROKEAHA.118.021540","volume":"49","author":"I Garc\u00eda-Y\u00e9benes","year":"2018","unstructured":"Garc\u00eda-Y\u00e9benes I, Garc\u00eda-Culebras A, Pe\u00f1a-Mart\u00ednez C, Fern\u00e1ndez-L\u00f3pez D, D\u00edaz-Guzm\u00e1n J, Negredo P et al (2018) Iron overload exacerbates the risk of hemorrhagic transformation after tPA (tissue-type plasminogen activator) administration in thromboembolic stroke mice. Stroke. 49(9):2163\u20132172","journal-title":"Stroke."},{"key":"4238_CR52","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.freeradbiomed.2018.06.037","volume":"133","author":"H Kawabata","year":"2019","unstructured":"Kawabata H (2019) Transferrin and transferrin receptors update. Free Radical Bio Med 133:46\u201354","journal-title":"Free Radical Bio Med"},{"key":"4238_CR53","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.freeradbiomed.2018.07.020","volume":"133","author":"I Yanatori","year":"2019","unstructured":"Yanatori I, Kishi F (2019) DMT1 and iron transport. Free Radical Bio Med 133:55\u201363","journal-title":"Free Radical Bio Med"},{"issue":"3","key":"4238_CR54","doi-asserted-by":"publisher","first-page":"e00192","DOI":"10.1042\/BSR20150014","volume":"35","author":"G Rishi","year":"2015","unstructured":"Rishi G, Wallace DF, Subramaniam VN (2015) Hepcidin: regulation of the master iron regulator. Biosci Rep 35(3):e00192","journal-title":"Biosci Rep"},{"issue":"5","key":"4238_CR55","doi-asserted-by":"publisher","first-page":"BSR20191499","DOI":"10.1042\/BSR20191499","volume":"40","author":"G Rishi","year":"2020","unstructured":"Rishi G, Secondes ES, Wallace DF, Subramaniam VN (2020) Evidence for dimerization of ferroportin in a human hepatic cell line using proximity ligation assays. Biosci Rep 40(5):BSR20191499","journal-title":"Biosci Rep"},{"issue":"1","key":"4238_CR56","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1021\/acs.nanolett.9b04974","volume":"20","author":"J Shi","year":"2020","unstructured":"Shi J, Yu W, Xu L, Yin N, Liu W, Zhang K et al (2020) Bioinspired nanosponge for salvaging ischemic stroke via free radical scavenging and self-adapted oxy gen regulating. Nano Lett 20(1):780\u2013789","journal-title":"Nano Lett"},{"key":"4238_CR57","doi-asserted-by":"publisher","first-page":"6643382","DOI":"10.1155\/2021\/6643382","volume":"2021","author":"JX Ren","year":"2021","unstructured":"Ren JX, Li C, Yan XL, Qu Y, Yang Y, Guo ZN (2021) Crosstalk between oxidative stress and ferroptosis\/oxytosis in ischemic stroke: possible targets and molecular mechanisms. Oxidative Med Cell Longev 2021:6643382","journal-title":"Oxidative Med Cell Longev"},{"issue":"1","key":"4238_CR58","first-page":"147","volume":"43","author":"J Cheng","year":"2020","unstructured":"Cheng J, Fan YQ, Liu BH, Zhou H, Wang JM, Chen QX (2020) ACSL4 suppresses glioma cells proliferation via activating ferroptosis. Oncol Rep 43(1):147\u2013158","journal-title":"Oncol Rep"},{"key":"4238_CR59","doi-asserted-by":"publisher","first-page":"632354","DOI":"10.3389\/fncel.2021.632354","volume":"15","author":"J Chen","year":"2021","unstructured":"Chen J, Yang L, Geng L, He J, Chen L, Sun Q et al (2021) Inhibition of acyl-coa synthetase long-chain family member 4 facilitates neurological recovery after stroke by regulation ferroptosis. Front Cell Neurosci 15:632354","journal-title":"Front Cell Neurosci"},{"key":"4238_CR60","doi-asserted-by":"publisher","first-page":"114630","DOI":"10.1016\/j.ejmech.2022.114630","volume":"242","author":"J Guo","year":"2022","unstructured":"Guo J, Cheng M, Liu P, Cao D, Luo J, Wan Y et al (2022) A multi-target directed ligands strategy for the treatment of Alzheimer's disease: dimethyl fumarate plus tranilast modified dithiocarbate as AChE inhibitor and Nrf2 activator. Eur J Med Chem 242:114630","journal-title":"Eur J Med Chem"},{"key":"4238_CR61","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.ejphar.2014.01.012","volume":"726","author":"MA Pereira de \u00c1vila","year":"2014","unstructured":"Pereira de \u00c1vila MA, Giusti-Paiva A, Giovani de Oliveira Nascimento C (2014) The peripheral antinociceptive effect induced by the heme oxygenase\/carbon monoxide pathway is associated with ATP-sensitive K+ channels. Eur J Pharmacol 726:41\u201348","journal-title":"Eur J Pharmacol"},{"key":"4238_CR62","doi-asserted-by":"publisher","first-page":"113683","DOI":"10.1016\/j.expneurol.2021.113683","volume":"341","author":"LM Zhang","year":"2021","unstructured":"Zhang LM, Zhang DX, Zheng WC, Hu JS, Fu L, Li Y et al (2021) CORM-3 exerts a neuroprotective effect in a rodent model of traumatic brain injury via the bidirectional gut-brain interactions. Exp Neurol 341:113683","journal-title":"Exp Neurol"},{"issue":"4","key":"4238_CR63","doi-asserted-by":"publisher","first-page":"281","DOI":"10.4103\/0250-474X.107047","volume":"74","author":"HM Soni","year":"2012","unstructured":"Soni HM, Jain MR, Mehta AA (2012) Mechanism(s) involved in carbon monoxide-releasing Molecule-2-mediated cardioprotection during ischaemia-reperfusion injury in isolated rat heart. Indian J Pharm Sci 74(4):281\u2013291","journal-title":"Indian J Pharm Sci"},{"issue":"4","key":"4238_CR64","doi-asserted-by":"publisher","first-page":"464","DOI":"10.2174\/1567202617999200730213259","volume":"17","author":"K Lu","year":"2020","unstructured":"Lu K, Wu WJ, Zhang C, Zhu YL, Zhong JQ, Li J (2020) CORM-3 regulates microglia activity, prevents neuronal injury, and improves memory function during radiation-induced brain injury. Curr Neurovasc Res 17(4):464\u2013470","journal-title":"Curr Neurovasc Res"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04238-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04238-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04238-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T09:17:45Z","timestamp":1732267065000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04238-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,20]]},"references-count":64,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["4238"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04238-w","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,20]]},"assertion":[{"value":"19 October 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The animal experiment was conducted by the national and institutional guidelines on ethics and biosafety, and the protocol was approved by the Institutional Animal Care and Use Committee of Xuzhou Medical University (License ID: 201907W079).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}