{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:07:58Z","timestamp":1784041678581,"version":"3.55.0"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T00:00:00Z","timestamp":1718668800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]},{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]},{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]},{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]},{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]},{"name":"Deputyship for Research & Innovation, Ministry of Education in Saudi Arabia","award":["IFPRC-168-141-2020"],"award-info":[{"award-number":["IFPRC-168-141-2020"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12035-024-04310-5","type":"journal-article","created":{"date-parts":[[2024,6,18]],"date-time":"2024-06-18T21:01:44Z","timestamp":1718744504000},"page":"604-625","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Black Seed Oil-Based Curcumin Nanoformulations Ameliorated Cuprizone-Induced Demyelination in the Mouse Hippocampus"],"prefix":"10.1007","volume":"62","author":[{"given":"Mohammad Zubair","family":"Alam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hala Abubaker","family":"Bagabir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Alameen Faisal","family":"Zaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thamer M. A.","family":"Alqurashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrah S.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsin","family":"Kazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam Md","family":"Ashraf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gadah Ali","family":"Alshahrany","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Ahmed","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal Mohammed","family":"Bakhalgi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Juweiriya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Al-Thepyani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanin Abdulbaset","family":"AboTaleb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahaf Saeed","family":"Aldhahri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamal Said Abd","family":"El-Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad A.","family":"Al-Abbasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loay Khaled","family":"Eibani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faisal Jaman","family":"Alzahrani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Sajjad Ahmad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,18]]},"reference":[{"key":"4310_CR1","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJMra1401483","volume":"378","author":"DS Reich","year":"2018","unstructured":"Reich DS, Lucchinetti CF, Calabresi PA (2018) Multiple sclerosis. N Engl J Med 378:169\u2013180. https:\/\/doi.org\/10.1056\/NEJMra1401483","journal-title":"N Engl J Med"},{"key":"4310_CR2","doi-asserted-by":"publisher","first-page":"12761","DOI":"10.1038\/s41598-022-16840-w","volume":"12","author":"D Moezzi","year":"2022","unstructured":"Moezzi D, Dong Y, Jain RW et al (2022) Expression of antioxidant enzymes in lesions of multiple sclerosis and its models. Sci Rep 12:12761. https:\/\/doi.org\/10.1038\/s41598-022-16840-w","journal-title":"Sci Rep"},{"key":"4310_CR3","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1007\/s12031-019-01425-6","volume":"70","author":"HA Abo Taleb","year":"2020","unstructured":"Abo Taleb HA, Alghamdi BS (2020) Neuroprotective effects of melatonin during demyelination and remyelination stages in a mouse model of multiple sclerosis. J Mol Neurosci 70:386\u2013402. https:\/\/doi.org\/10.1007\/s12031-019-01425-6","journal-title":"J Mol Neurosci"},{"key":"4310_CR4","doi-asserted-by":"publisher","unstructured":"Ponath G, Park C, Pitt D (2018) The role of astrocytes in multiple sclerosis. Front. Immunol 9:217. https:\/\/doi.org\/10.3389\/fimmu.2018.00217","DOI":"10.3389\/fimmu.2018.00217"},{"key":"4310_CR5","doi-asserted-by":"publisher","unstructured":"Zhang S-Y, Gui L-N, Liu Y-Y, Shi S, Cheng Y (2020) Oxidative Stress Marker Aberrations in Multiple Sclerosis: A Meta-Analysis Study. Front Neurosci 14:823. https:\/\/doi.org\/10.3389\/fnins.2020.00823","DOI":"10.3389\/fnins.2020.00823"},{"key":"4310_CR6","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.3390\/jcm8111815","volume":"8","author":"R Padureanu","year":"2019","unstructured":"Padureanu R, Albu CV, Mititelu RR et al (2019) Oxidative stress and inflammation interdependence in multiple sclerosis. J Clin Med 8:1815. https:\/\/doi.org\/10.3390\/jcm8111815","journal-title":"J Clin Med"},{"key":"4310_CR7","doi-asserted-by":"publisher","first-page":"2326","DOI":"10.1002\/ptr.7751","volume":"37","author":"A Khan","year":"2023","unstructured":"Khan A, Shal B, Khan AU et al (2023) Suppression of MAPK\/NF-kB and activation of Nrf2 signaling by ajugarin-I in EAE model of multiple sclerosis. Phytother Res 37:2326\u20132343. https:\/\/doi.org\/10.1002\/ptr.7751","journal-title":"Phytother Res"},{"key":"4310_CR8","doi-asserted-by":"publisher","first-page":"100019","DOI":"10.1016\/j.dscb.2021.100019","volume":"3","author":"S Upadhayay","year":"2021","unstructured":"Upadhayay S, Mehan S (2021) Targeting Nrf2\/HO-1 anti-oxidant signaling pathway in the progression of multiple sclerosis and influences on neurological dysfunctions. Brain Disord 3:100019. https:\/\/doi.org\/10.1016\/j.dscb.2021.100019","journal-title":"Brain Disord"},{"key":"4310_CR9","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1016\/B978-0-444-52001-2.00008-X","volume":"122","author":"AP Robinson","year":"2014","unstructured":"Robinson AP, Harp CT, Noronha A, Miller SD (2014) The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment. Handb Clin Neurol 122:173\u2013189. https:\/\/doi.org\/10.1016\/B978-0-444-52001-2.00008-X","journal-title":"Handb Clin Neurol"},{"key":"4310_CR10","doi-asserted-by":"publisher","first-page":"576998","DOI":"10.1016\/j.jneuroim.2019.576998","volume":"334","author":"M Nickel","year":"2019","unstructured":"Nickel M, Eid F, Jukkola P, Gu C (2019) Copper chelation and autoimmunity differentially impact myelin in the hippocampal-prefrontal circuit. J Neuroimmunol 334:576998. https:\/\/doi.org\/10.1016\/j.jneuroim.2019.576998","journal-title":"J Neuroimmunol"},{"key":"4310_CR11","doi-asserted-by":"publisher","first-page":"644","DOI":"10.3906\/biy-2104-88","volume":"45","author":"T Av\u015far","year":"2021","unstructured":"Av\u015far T, Erdem G, Terzio\u011flu G, Turanli E (2021) Investigation of neuro-inflammatory parameters in a cuprizone induced mouse model of multiple sclerosis. Turk J Biol 45:644\u2013655. https:\/\/doi.org\/10.3906\/biy-2104-88","journal-title":"Turk J Biol"},{"key":"4310_CR12","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1080\/14737175.2018.1459190","volume":"18","author":"T Hochstrasser","year":"2018","unstructured":"Hochstrasser T, Jiangshan Z, R\u00fchling S et al (2018) Do pre-clinical multiple sclerosis models allow us to measure neurodegeneration and clinical progression? Expert Rev Neurother 18:351\u2013353. https:\/\/doi.org\/10.1080\/14737175.2018.1459190","journal-title":"Expert Rev Neurother"},{"key":"4310_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.3390\/bs12030070","volume":"12","author":"RS Aldhahri","year":"2022","unstructured":"Aldhahri RS, Alghamdi BS, Alzahrani NA et al (2022) Biochanin A improves memory decline and brain pathology in cuprizone-induced mouse model of multiple sclerosis. Behav Sci 12:70. https:\/\/doi.org\/10.3390\/bs12030070","journal-title":"Behav Sci"},{"key":"4310_CR14","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.3390\/molecules25071703","volume":"25","author":"M Kazi","year":"2020","unstructured":"Kazi M, Shahba AA, Alrashoud S et al (2020) Bioactive self-nanoemulsifying drug delivery systems (Bio-SNEDDS) for combined oral delivery of curcumin and piperine. Molecules 25:1703. https:\/\/doi.org\/10.3390\/molecules25071703","journal-title":"Molecules"},{"key":"4310_CR15","doi-asserted-by":"publisher","first-page":"112502","DOI":"10.1016\/j.jep.2019.112502","volume":"250","author":"H Fan","year":"2020","unstructured":"Fan H, Wang X, Li X et al (2020) Curcumin, as a pleiotropic agent, improves doxorubicin-induced nephrotic syndrome in rats. J Ethnopharmacol 250:112502. https:\/\/doi.org\/10.1016\/j.jep.2019.112502","journal-title":"J Ethnopharmacol"},{"key":"4310_CR16","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.neuropharm.2015.07.013","volume":"99","author":"M Mohajeri","year":"2015","unstructured":"Mohajeri M, Sadeghizadeh M, Najafi F, Javan M (2015) Polymerized nano-curcumin attenuates neurological symptoms in EAE model of multiple sclerosis through down regulation of inflammatory and oxidative processes and enhancing neuroprotection and myelin repair. Neuropharmacology 99:156\u2013167. https:\/\/doi.org\/10.1016\/j.neuropharm.2015.07.013","journal-title":"Neuropharmacology"},{"key":"4310_CR17","doi-asserted-by":"publisher","first-page":"2946","DOI":"10.1074\/jbc.M113.497909","volume":"289","author":"SO Adeosun","year":"2014","unstructured":"Adeosun SO, Hou X, Zheng B et al (2014) Cognitive deficits and disruption of neurogenesis in a mouse model of apolipoprotein E4 domain interaction. J Biol Chem 289:2946\u20132959. https:\/\/doi.org\/10.1074\/jbc.M113.497909","journal-title":"J Biol Chem"},{"key":"4310_CR18","doi-asserted-by":"publisher","first-page":"113100","DOI":"10.1016\/j.bbr.2020.113100","volume":"402","author":"S Labban","year":"2021","unstructured":"Labban S, Alghamdi BS, Alshehri FS, Kurdi M (2021) Effects of melatonin and resveratrol on recognition memory and passive avoidance performance in a mouse model of Alzheimer\u2019s disease. Behav Brain Res 402:113100. https:\/\/doi.org\/10.1016\/j.bbr.2020.113100","journal-title":"Behav Brain Res"},{"key":"4310_CR19","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.3892\/etm.2017.4410","volume":"13","author":"W-J Huang","year":"2017","unstructured":"Huang W-J, Chen W-W, Zhang X (2017) Multiple sclerosis: pathology, diagnosis and treatments. Exp Ther Med 13:3163\u20133166. https:\/\/doi.org\/10.3892\/etm.2017.4410","journal-title":"Exp Ther Med"},{"key":"4310_CR20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41572-018-0041-4","volume":"4","author":"M Filippi","year":"2018","unstructured":"Filippi M, Bar-Or A, Piehl F et al (2018) Multiple sclerosis. Nat Rev Dis Primers 4:1\u201327. https:\/\/doi.org\/10.1038\/s41572-018-0041-4","journal-title":"Nat Rev Dis Primers"},{"key":"4310_CR21","doi-asserted-by":"publisher","first-page":"a028936","DOI":"10.1101\/cshperspect.a028936","volume":"8","author":"H Lassmann","year":"2018","unstructured":"Lassmann H (2018) Multiple sclerosis pathology. Cold Spring Harb Perspect Med 8:a028936. https:\/\/doi.org\/10.1101\/cshperspect.a028936","journal-title":"Cold Spring Harb Perspect Med"},{"key":"4310_CR22","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.pneurobio.2018.07.004","volume":"169","author":"I Ferrer","year":"2018","unstructured":"Ferrer I (2018) Oligodendrogliopathy in neurodegenerative diseases with abnormal protein aggregates: the forgotten partner. Prog Neurobiol 169:24\u201354. https:\/\/doi.org\/10.1016\/j.pneurobio.2018.07.004","journal-title":"Prog Neurobiol"},{"key":"4310_CR23","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1093\/brain\/awy338","volume":"142","author":"Y You","year":"2019","unstructured":"You Y, Joseph C, Wang C et al (2019) Demyelination precedes axonal loss in the transneuronal spread of human neurodegenerative disease. Brain 142:426\u2013442. https:\/\/doi.org\/10.1093\/brain\/awy338","journal-title":"Brain"},{"key":"4310_CR24","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1038\/nrd.2017.115","volume":"16","author":"JR Plemel","year":"2017","unstructured":"Plemel JR, Liu W-Q, Yong VW (2017) Remyelination therapies: a new direction and challenge in multiple sclerosis. Nat Rev Drug Discov 16:617\u2013634. https:\/\/doi.org\/10.1038\/nrd.2017.115","journal-title":"Nat Rev Drug Discov"},{"key":"4310_CR25","doi-asserted-by":"publisher","first-page":"6373","DOI":"10.3390\/ijms24076373","volume":"24","author":"X Zhao","year":"2023","unstructured":"Zhao X, Jacob C (2023) Mechanisms of demyelination and remyelination strategies for multiple sclerosis. Int J Mol Sci 24:6373. https:\/\/doi.org\/10.3390\/ijms24076373","journal-title":"Int J Mol Sci"},{"key":"4310_CR26","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s42269-022-00708-0","volume":"46","author":"N Shaheen","year":"2022","unstructured":"Shaheen N, Azam A, Ganguly A et al (2022) Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems. Bull Natl Res Cent 46:26. https:\/\/doi.org\/10.1186\/s42269-022-00708-0","journal-title":"Bull Natl Res Cent"},{"key":"4310_CR27","doi-asserted-by":"publisher","first-page":"921","DOI":"10.3390\/antiox9100921","volume":"9","author":"RM Pop","year":"2020","unstructured":"Pop RM, Sabin O, \u0218oimi\u021ba S et al (2020) Nigella sativa\u2019s anti-inflammatory and antioxidative effects in experimental inflammation. Antioxidants (Basel) 9:921. https:\/\/doi.org\/10.3390\/antiox9100921","journal-title":"Antioxidants (Basel)"},{"key":"4310_CR28","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3390\/antiox8020051","volume":"8","author":"L Bordoni","year":"2019","unstructured":"Bordoni L, Fedeli D, Nasuti C et al (2019) Antioxidant and anti-inflammatory properties of Nigella sativa oil in human pre-adipocytes. Antioxidants (Basel) 8:51. https:\/\/doi.org\/10.3390\/antiox8020051","journal-title":"Antioxidants (Basel)"},{"key":"4310_CR29","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.3390\/ijms25031823","volume":"25","author":"S Uzzan","year":"2024","unstructured":"Uzzan S, Rostevanov I-S, Rubin E et al (2024) Chronic treatment with Nigella sativa oil exerts antimanic properties and reduces brain inflammation in rats. Int J Mol Sci 25:1823. https:\/\/doi.org\/10.3390\/ijms25031823","journal-title":"Int J Mol Sci"},{"key":"4310_CR30","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","volume":"2","author":"T Liu","year":"2017","unstructured":"Liu T, Zhang L, Joo D, Sun S-C (2017) NF-\u03baB signaling in inflammation. Signal Transduct Target Ther 2:17023. https:\/\/doi.org\/10.1038\/sigtrans.2017.23","journal-title":"Signal Transduct Target Ther"},{"key":"4310_CR31","doi-asserted-by":"publisher","first-page":"899797","DOI":"10.3389\/fnut.2022.899797","volume":"9","author":"J Wei","year":"2022","unstructured":"Wei J, Wang B, Chen Y et al (2022) The immunomodulatory effects of active ingredients from Nigella sativa in RAW264.7 cells through NF-\u03baB\/MAPK signaling pathways. Front Nutr 9:899797. https:\/\/doi.org\/10.3389\/fnut.2022.899797","journal-title":"Front Nutr"},{"key":"4310_CR32","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1007\/978-3-319-41334-1_8","volume":"928","author":"G Derosa","year":"2016","unstructured":"Derosa G, Maffioli P, Sahebkar A (2016) Piperine and its role in chronic diseases. Adv Exp Med Biol 928:173\u2013184. https:\/\/doi.org\/10.1007\/978-3-319-41334-1_8","journal-title":"Adv Exp Med Biol"},{"key":"4310_CR33","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.ejps.2009.02.019","volume":"37","author":"J Shaikh","year":"2009","unstructured":"Shaikh J, Ankola DD, Beniwal V et al (2009) Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer. Eur J Pharm Sci 37:223\u2013230. https:\/\/doi.org\/10.1016\/j.ejps.2009.02.019","journal-title":"Eur J Pharm Sci"},{"key":"4310_CR34","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1038\/nprot.2006.205","volume":"1","author":"RA Bevins","year":"2006","unstructured":"Bevins RA, Besheer J (2006) Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u201crecognition memory.\u201d Nat Protoc 1:1306\u20131311. https:\/\/doi.org\/10.1038\/nprot.2006.205","journal-title":"Nat Protoc"},{"key":"4310_CR35","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.beproc.2011.12.004","volume":"89","author":"CJ Heyser","year":"2012","unstructured":"Heyser CJ, Chemero A (2012) Novel object exploration in mice: not all objects are created equal. Behav Proc 89:232\u2013238. https:\/\/doi.org\/10.1016\/j.beproc.2011.12.004","journal-title":"Behav Proc"},{"key":"4310_CR36","doi-asserted-by":"publisher","first-page":"332","DOI":"10.3389\/fphar.2019.00332","volume":"10","author":"Y Zhang","year":"2019","unstructured":"Zhang Y, Bi X, Adebiyi O et al (2019) Venlafaxine improves the cognitive impairment and depression-like behaviors in a cuprizone mouse model by alleviating demyelination and neuroinflammation in the brain. Front Pharmacol 10:332. https:\/\/doi.org\/10.3389\/fphar.2019.00332","journal-title":"Front Pharmacol"},{"key":"4310_CR37","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.psychres.2017.07.075","volume":"257","author":"Z-Y Sun","year":"2017","unstructured":"Sun Z-Y, Gu H-S, Chen X et al (2017) A novel flavanone derivative ameliorates cuprizone-induced behavioral changes and white matter pathology in the brain of mice. Psychiatry Res 257:249\u2013259. https:\/\/doi.org\/10.1016\/j.psychres.2017.07.075","journal-title":"Psychiatry Res"},{"key":"4310_CR38","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1007\/s11481-018-9799-0","volume":"13","author":"J Zhang","year":"2018","unstructured":"Zhang J, Yang L, Fang Z et al (2018) Adenosine promotes the recovery of mice from the cuprizone-induced behavioral and morphological changes while effecting on microglia and inflammatory cytokines in the brain. J Neuroimmune Pharmacol 13:412\u2013425. https:\/\/doi.org\/10.1007\/s11481-018-9799-0","journal-title":"J Neuroimmune Pharmacol"},{"key":"4310_CR39","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.npep.2017.10.002","volume":"66","author":"M Murakami","year":"2017","unstructured":"Murakami M, Nagahama M, Abe Y, Niikura T (2017) Humanin affects object recognition and gliosis in short-term cuprizone-treated mice. Neuropeptides 66:90\u201396. https:\/\/doi.org\/10.1016\/j.npep.2017.10.002","journal-title":"Neuropeptides"},{"key":"4310_CR40","doi-asserted-by":"publisher","first-page":"e02102","DOI":"10.1016\/j.heliyon.2019.e02102","volume":"5","author":"GO Omotoso","year":"2019","unstructured":"Omotoso GO, Olajide OJ, Gbadamosi IT et al (2019) Cuprizone toxicity and Garcinia kola biflavonoid complex activity on hippocampal morphology and neurobehaviour. Heliyon 5:e02102. https:\/\/doi.org\/10.1016\/j.heliyon.2019.e02102","journal-title":"Heliyon"},{"key":"4310_CR41","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1111\/jnc.13242","volume":"135","author":"J Liu","year":"2015","unstructured":"Liu J, Tian D, Murugan M et al (2015) Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage. J Neurochem 135:347\u2013356. https:\/\/doi.org\/10.1111\/jnc.13242","journal-title":"J Neurochem"},{"key":"4310_CR42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jneuroim.2013.06.012","volume":"262","author":"P Acs","year":"2013","unstructured":"Acs P, Selak MA, Komoly S, Kalman B (2013) Distribution of oligodendrocyte loss and mitochondrial toxicity in the cuprizone-induced experimental demyelination model. J Neuroimmunol 262:128\u2013131. https:\/\/doi.org\/10.1016\/j.jneuroim.2013.06.012","journal-title":"J Neuroimmunol"},{"key":"4310_CR43","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.neuint.2015.08.015","volume":"90","author":"Y Xuan","year":"2015","unstructured":"Xuan Y, Yan G, Wu R et al (2015) The cuprizone-induced changes in (1)H-MRS metabolites and oxidative parameters in C57BL\/6 mouse brain: effects of quetiapine. Neurochem Int 90:185\u2013192. https:\/\/doi.org\/10.1016\/j.neuint.2015.08.015","journal-title":"Neurochem Int"},{"key":"4310_CR44","doi-asserted-by":"publisher","first-page":"11215","DOI":"10.1021\/acs.jafc.0c04604","volume":"68","author":"C Liu","year":"2020","unstructured":"Liu C, Zhang N, Zhang R et al (2020) Cuprizone-induced demyelination in mouse hippocampus is alleviated by ketogenic diet. J Agric Food Chem 68:11215\u201311228. https:\/\/doi.org\/10.1021\/acs.jafc.0c04604","journal-title":"J Agric Food Chem"},{"key":"4310_CR45","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.4103\/1673-5374.237109","volume":"13","author":"Y Yue","year":"2018","unstructured":"Yue Y, Stone S, Lin W (2018) Role of nuclear factor \u03baB in multiple sclerosis and experimental autoimmune encephalomyelitis. Neural Regen Res 13:1507\u20131515. https:\/\/doi.org\/10.4103\/1673-5374.237109","journal-title":"Neural Regen Res"},{"key":"4310_CR46","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1608-17.2017","author":"S Stone","year":"2017","unstructured":"Stone S, Jamison S, Yue Y et al (2017) NF-\u03baB activation protects oligodendrocytes against inflammation. J Neurosci. https:\/\/doi.org\/10.1523\/JNEUROSCI.1608-17.2017","journal-title":"J Neurosci"},{"key":"4310_CR47","doi-asserted-by":"publisher","unstructured":"Ghaiad HR, Nooh MM, El-Sawalhi MM, Shaheen AA (2017) Resveratrol promotes remyelination in cuprizone model of multiple sclerosis: biochemical and histological study. Mol Neurobiol 54:3219\u20133229. https:\/\/doi.org\/10.1007\/s12035-016-9891-5","DOI":"10.1007\/s12035-016-9891-5"},{"key":"4310_CR48","doi-asserted-by":"publisher","unstructured":"Elbaz EM, Senousy MA, El-Tanbouly DM, Sayed RH (018) Neuroprotective effect of linagliptin against cuprizone-induced demyelination and behavioural dysfunction in mice: A pivotal role of AMPK\/SIRT1 and JAK2\/STAT3\/NF-\u03baB signalling pathway modulation. Toxicol Appl Pharmacol 352:153\u2013161. https:\/\/doi.org\/10.1016\/j.taap.2018.05.035","DOI":"10.1016\/j.taap.2018.05.035"},{"key":"4310_CR49","doi-asserted-by":"publisher","first-page":"2290","DOI":"10.3390\/cells9102290","volume":"9","author":"D Fresegna","year":"2020","unstructured":"Fresegna D, Bullitta S, Musella A et al (2020) Re-examining the role of TNF in MS pathogenesis and therapy. Cells 9:2290. https:\/\/doi.org\/10.3390\/cells9102290","journal-title":"Cells"},{"key":"4310_CR50","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.cyto.2016.08.003","volume":"101","author":"AK Mehta","year":"2018","unstructured":"Mehta AK, Gracias DT, Croft M (2018) TNF activity and T cells. Cytokine 101:14\u201318. https:\/\/doi.org\/10.1016\/j.cyto.2016.08.003","journal-title":"Cytokine"},{"key":"4310_CR51","doi-asserted-by":"publisher","unstructured":"Maguire AD, Bethea JR, Kerr BJ (2021) TNF\u03b1 in MS and its animal models: Implications for chronic pain in the disease. Front Neurol\u00a012:780876. https:\/\/doi.org\/10.3389\/fneur.2021.780876","DOI":"10.3389\/fneur.2021.780876"},{"key":"4310_CR52","doi-asserted-by":"publisher","first-page":"516","DOI":"10.3390\/ddc2020027","volume":"2","author":"HK Rashwan","year":"2023","unstructured":"Rashwan HK, Mahgoub S, Abuelezz NZ, Amin HK (2023) Black cumin seed (Nigella sativa) in inflammatory disorders: therapeutic potential and promising molecular mechanisms. Drugs Drug Candidates 2:516\u2013537. https:\/\/doi.org\/10.3390\/ddc2020027","journal-title":"Drugs Drug Candidates"},{"key":"4310_CR53","doi-asserted-by":"publisher","first-page":"16360","DOI":"10.1074\/jbc.M910419199","volume":"275","author":"R Takano","year":"2000","unstructured":"Takano R, Hisahara S, Namikawa K et al (2000) Nerve growth factor protects oligodendrocytes from tumor necrosis factor-\u03b1-induced injury through Akt-mediated signaling mechanisms*. J Biol Chem 275:16360\u201316365. https:\/\/doi.org\/10.1074\/jbc.M910419199","journal-title":"J Biol Chem"},{"key":"4310_CR54","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jneuroim.2017.11.012","volume":"314","author":"F Monteleone","year":"2018","unstructured":"Monteleone F, Nicoletti CG, Stampanoni Bassi M et al (2018) Nerve growth factor is elevated in the CSF of patients with multiple sclerosis and central neuropathic pain. J Neuroimmunol 314:89\u201393. https:\/\/doi.org\/10.1016\/j.jneuroim.2017.11.012","journal-title":"J Neuroimmunol"},{"key":"4310_CR55","doi-asserted-by":"publisher","first-page":"405","DOI":"10.3390\/cells10020405","volume":"10","author":"R Brandi","year":"2021","unstructured":"Brandi R, Fabiano M, Giorgi C et al (2021) Nerve growth factor neutralization promotes oligodendrogenesis by increasing miR-219a-5p levels. Cells 10:405. https:\/\/doi.org\/10.3390\/cells10020405","journal-title":"Cells"},{"key":"4310_CR56","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s11010-016-2770-6","volume":"420","author":"A Morel","year":"2016","unstructured":"Morel A, Miller E, Bijak M, Saluk J (2016) The increased level of COX-dependent arachidonic acid metabolism in blood platelets from secondary progressive multiple sclerosis patients. Mol Cell Biochem 420:85\u201394. https:\/\/doi.org\/10.1007\/s11010-016-2770-6","journal-title":"Mol Cell Biochem"},{"key":"4310_CR57","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.jneuroim.2003.12.021","volume":"149","author":"JW Rose","year":"2004","unstructured":"Rose JW, Hill KE, Watt HE, Carlson NG (2004) Inflammatory cell expression of cyclooxygenase-2 in the multiple sclerosis lesion. J Neuroimmunol 149:40\u201349. https:\/\/doi.org\/10.1016\/j.jneuroim.2003.12.021","journal-title":"J Neuroimmunol"},{"key":"4310_CR58","doi-asserted-by":"publisher","first-page":"e462","DOI":"10.1002\/term.2276","volume":"12","author":"M Ghasemi-Kasman","year":"2018","unstructured":"Ghasemi-Kasman M, Zare L, Baharvand H, Javan M (2018) In vivo conversion of astrocytes to myelinating cells by miR-302\/367 and valproate to enhance myelin repair. J Tissue Eng Regen Med 12:e462\u2013e472. https:\/\/doi.org\/10.1002\/term.2276","journal-title":"J Tissue Eng Regen Med"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04310-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04310-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04310-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:07:35Z","timestamp":1736374055000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04310-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,18]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["4310"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04310-5","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,18]]},"assertion":[{"value":"27 February 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Animal experiments were conducted in accordance with the guidelines of the animal unit committee at KFMRC. The study was conducted in accordance with the Declaration of Helsinki and approved by the Biomedical Ethics Research Committee (approval no. ACUC-22\u20131-2) at King Abdulaziz University and followed the rules and regulations of the Animal Care and Use Committee at the KFMRC, which complied with the \u201cSystem of Ethics of Research on Living Creatures\u201d guidelines prepared by King Abdulaziz City for Science and Technology and were approved by Royal Decree No. M\/59 dated 24 August 2010. The study was performed at the King Fahad Medical Research Center, Jeddah, Saudi Arabia, from June 1, 2022, to July 16, 2022.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"All authors gave their consent to participate in this project.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"All authors have seen the manuscript and agreed to publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}