{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T03:30:35Z","timestamp":1775100635904,"version":"3.50.1"},"reference-count":215,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T00:00:00Z","timestamp":1720224000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1007\/s12035-024-04321-2","type":"journal-article","created":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T07:01:47Z","timestamp":1720249307000},"page":"1225-1246","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Effects of Fisetin and Curcumin on Oxidative Damage Caused by Transition Metals in Neurodegenerative Diseases"],"prefix":"10.1007","volume":"62","author":[{"given":"Geir","family":"Bj\u00f8rklund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petro","family":"Oliinyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Khavrona","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Lozynska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Lysiuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Darmohray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Halyna","family":"Antonyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia","family":"Dub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasyl","family":"Zayachuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olha","family":"Antoniv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oksana","family":"Rybak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimiliano","family":"Peana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,6]]},"reference":[{"key":"4321_CR1","unstructured":"World Health Organization (2017) Mental health of older adults. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/mental-health-of-older-adults. Accessed 22 Dec 2022"},{"issue":"1","key":"4321_CR2","doi-asserted-by":"publisher","first-page":"361","DOI":"10.3233\/JAD-170811","volume":"62","author":"L Xu","year":"2018","unstructured":"Xu L, Zhang W, Liu X, Zhang C, Wang P, Zhao X (2018) Circulatory levels of toxic metals (aluminum, cadmium, mercury, lead) in patients with Alzheimer\u2019s disease: a quantitative meta-analysis and systematic review. J Alzheimers Dis 62(1):361\u2013372. https:\/\/doi.org\/10.3233\/JAD-170811","journal-title":"J Alzheimers Dis"},{"key":"4321_CR3","doi-asserted-by":"publisher","first-page":"135873","DOI":"10.1016\/j.neulet.2021.135873","volume":"753","author":"K Raj","year":"2021","unstructured":"Raj K, Kaur P, Gupta GD, Singh S (2021) Metals associated neurodegeneration in Parkinson\u2019s disease: insight to physiological, pathological mechanisms and management. Neurosci Lett 753:135873. https:\/\/doi.org\/10.1016\/j.neulet.2021.135873","journal-title":"Neurosci Lett"},{"issue":"1\u20132","key":"4321_CR4","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.jns.2015.10.023","volume":"359","author":"B Bocca","year":"2015","unstructured":"Bocca B, Forte G, Oggiano R, Clemente S, Asara Y, Peruzzu A, Farace C, Pala S et al (2015) Level of neurotoxic metals in amyotrophic lateral sclerosis: a population-based case-control study. J Neurol Sci 359(1\u20132):11\u201317. https:\/\/doi.org\/10.1016\/j.jns.2015.10.023","journal-title":"J Neurol Sci"},{"key":"4321_CR5","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.envres.2017.07.048","volume":"159","author":"CE Cicero","year":"2017","unstructured":"Cicero CE, Mostile G, Vasta R, Rapisarda V, Signorelli SS, Ferrante M, Zappia M, Nicoletti A (2017) Metals and neurodegenerative diseases. A systematic review. Environ Res 159:82\u201394. https:\/\/doi.org\/10.1016\/j.envres.2017.07.048","journal-title":"Environ Res"},{"issue":"2","key":"4321_CR6","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/imm.12922","volume":"154","author":"J Stephenson","year":"2018","unstructured":"Stephenson J, Nutma E, van der Valk P, Amor S (2018) Inflammation in CNS neurodegenerative diseases. Immunology 154(2):204\u2013219. https:\/\/doi.org\/10.1111\/imm.12922","journal-title":"Immunology"},{"issue":"23","key":"4321_CR7","doi-asserted-by":"publisher","first-page":"9105","DOI":"10.3390\/ijms21239105","volume":"21","author":"JP Dales","year":"2020","unstructured":"Dales JP, Desplat-Jego S (2020) Metal imbalance in neurodegenerative diseases with a specific concern to the brain of multiple sclerosis patients. Int J Mol Sci 21(23):9105. https:\/\/doi.org\/10.3390\/ijms21239105","journal-title":"Int J Mol Sci"},{"key":"4321_CR8","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.jinorgbio.2019.03.013","volume":"195","author":"MA Zoroddu","year":"2019","unstructured":"Zoroddu MA, Aaseth J, Crisponi G, Medici S, Peana M, Nurchi VM (2019) The essential metals for humans: a brief overview. J Inorg Biochem 195:120\u2013129. https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.03.013","journal-title":"J Inorg Biochem"},{"key":"4321_CR9","doi-asserted-by":"publisher","first-page":"720658","DOI":"10.4061\/2011\/720658","volume":"2011","author":"GA Salvador","year":"2010","unstructured":"Salvador GA, Uranga RM, Giusto NM (2010) Iron and mechanisms of neurotoxicity. Int J Alzheimers Dis 2011:720658. https:\/\/doi.org\/10.4061\/2011\/720658","journal-title":"Int J Alzheimers Dis"},{"key":"4321_CR10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.jtemb.2014.05.007","volume":"31","author":"P Dusek","year":"2015","unstructured":"Dusek P, Roos PM, Litwin T, Schneider SA, Flaten TP, Aaseth J (2015) The neurotoxicity of iron, copper and manganese in Parkinson\u2019s and Wilson\u2019s diseases. J Trace Elem Med Biol 31:193\u2013203. https:\/\/doi.org\/10.1016\/j.jtemb.2014.05.007","journal-title":"J Trace Elem Med Biol"},{"issue":"1","key":"4321_CR11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1172\/JCI17522","volume":"111","author":"S Przedborski","year":"2003","unstructured":"Przedborski S, Vila M, Jackson-Lewis V (2003) Neurodegeneration: what is it and where are we? J Clin Invest 111(1):3\u201310. https:\/\/doi.org\/10.1172\/JCI17522","journal-title":"J Clin Invest"},{"key":"4321_CR12","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1750-1326-4-8","volume":"4","author":"TE Golde","year":"2009","unstructured":"Golde TE (2009) The therapeutic importance of understanding mechanisms of neuronal cell death in neurodegenerative disease. Mol Neurodegener 4:8. https:\/\/doi.org\/10.1186\/1750-1326-4-8","journal-title":"Mol Neurodegener"},{"issue":"3","key":"4321_CR13","doi-asserted-by":"publisher","first-page":"289","DOI":"10.18999\/nagjms.80.3.289","volume":"80","author":"M Katsuno","year":"2018","unstructured":"Katsuno M, Sahashi K, Iguchi Y, Hashizume A (2018) Preclinical progression of neurodegenerative diseases. Nagoya J Med Sci 80(3):289\u2013298. https:\/\/doi.org\/10.18999\/nagjms.80.3.289","journal-title":"Nagoya J Med Sci"},{"key":"4321_CR14","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3389\/fnagi.2019.00155","volume":"11","author":"M Ayaz","year":"2019","unstructured":"Ayaz M, Sadiq A, Junaid M, Ullah F, Ovais M, Ullah I, Ahmed J, Shahid M (2019) Flavonoids as prospective neuroprotectants and their therapeutic propensity in aging associated neurological disorders. Front Aging Neurosci 11:155. https:\/\/doi.org\/10.3389\/fnagi.2019.00155","journal-title":"Front Aging Neurosci"},{"key":"4321_CR15","doi-asserted-by":"publisher","first-page":"6565396","DOI":"10.1155\/2020\/6565396","volume":"2020","author":"NS Mohd Sairazi","year":"2020","unstructured":"Mohd Sairazi NS, Sirajudeen KNS (2020) Natural products and their bioactive compounds: neuroprotective potentials against neurodegenerative diseases. Evid Based Complement Alternat Med 2020:6565396. https:\/\/doi.org\/10.1155\/2020\/6565396","journal-title":"Evid Based Complement Alternat Med"},{"key":"4321_CR16","doi-asserted-by":"publisher","unstructured":"Sharifi-Rad M, Lankatillake C, Dias DA, Docea AO, Mahomoodally MF, Lobine D, Chazot PL, Kurt B et al (2020) Impact of natural compounds on neurodegenerative disorders: from preclinical to pharmacotherapeutics. J Clin Med 9(4). https:\/\/doi.org\/10.3390\/jcm9041061","DOI":"10.3390\/jcm9041061"},{"key":"4321_CR17","doi-asserted-by":"publisher","unstructured":"Bjorklund G, Shanaida M, Lysiuk R, Butnariu M, Peana M, Sarac I, Strus O, Smetanina K et al (2022) Natural compounds and products from an anti-aging perspective. Molecules 27(20). https:\/\/doi.org\/10.3390\/molecules27207084","DOI":"10.3390\/molecules27207084"},{"issue":"7","key":"4321_CR18","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2174\/1871527319666200812224457","volume":"19","author":"W Zahra","year":"2020","unstructured":"Zahra W, Rai SN, Birla H, Singh SS, Rathore AS, Dilnashin H, Singh R, Keswani C et al (2020) Neuroprotection of rotenone-induced parkinsonism by ursolic acid in PD mouse model. CNS Neurol Disord Drug Targets 19(7):527\u2013540. https:\/\/doi.org\/10.2174\/1871527319666200812224457","journal-title":"CNS Neurol Disord Drug Targets"},{"issue":"3","key":"4321_CR19","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1007\/s12640-019-00038-6","volume":"36","author":"SN Rai","year":"2019","unstructured":"Rai SN, Zahra W, Singh SS, Birla H, Keswani C, Dilnashin H, Rathore AS, Singh R et al (2019) Anti-inflammatory activity of ursolic acid in MPTP-induced parkinsonian mouse model. Neurotox Res 36(3):452\u2013462. https:\/\/doi.org\/10.1007\/s12640-019-00038-6","journal-title":"Neurotox Res"},{"key":"4321_CR20","doi-asserted-by":"publisher","first-page":"6571484","DOI":"10.1155\/2020\/6571484","volume":"2020","author":"SS Singh","year":"2020","unstructured":"Singh SS, Rai SN, Birla H, Zahra W, Rathore AS, Dilnashin H, Singh R, Singh SP (2020) Neuroprotective effect of chlorogenic acid on mitochondrial dysfunction-mediated apoptotic death of DA neurons in a parkinsonian mouse model. Oxid Med Cell Longev 2020:6571484. https:\/\/doi.org\/10.1155\/2020\/6571484","journal-title":"Oxid Med Cell Longev"},{"key":"4321_CR21","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3389\/fphar.2018.00757","volume":"9","author":"SS Singh","year":"2018","unstructured":"Singh SS, Rai SN, Birla H, Zahra W, Kumar G, Gedda MR, Tiwari N, Patnaik R et al (2018) Effect of chlorogenic acid supplementation in MPTP-intoxicated mouse. Front Pharmacol 9:757. https:\/\/doi.org\/10.3389\/fphar.2018.00757","journal-title":"Front Pharmacol"},{"issue":"6","key":"4321_CR22","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.3390\/molecules25061267","volume":"25","author":"MS Uddin","year":"2020","unstructured":"Uddin MS, Kabir MT, Niaz K, Jeandet P, Clement C, Mathew B, Rauf A, Rengasamy KRR et al (2020) Molecular insight into the therapeutic promise of flavonoids against Alzheimer\u2019s disease. Molecules 25(6):1267. https:\/\/doi.org\/10.3390\/molecules25061267","journal-title":"Molecules"},{"issue":"3\u20134","key":"4321_CR23","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s12263-008-0091-4","volume":"3","author":"D Vauzour","year":"2008","unstructured":"Vauzour D, Vafeiadou K, Rodriguez-Mateos A, Rendeiro C, Spencer JP (2008) The neuroprotective potential of flavonoids: a multiplicity of effects. Genes Nutr 3(3\u20134):115\u2013126. https:\/\/doi.org\/10.1007\/s12263-008-0091-4","journal-title":"Genes Nutr"},{"key":"4321_CR24","doi-asserted-by":"publisher","first-page":"e47","DOI":"10.1017\/jns.2016.41","volume":"5","author":"AN Panche","year":"2016","unstructured":"Panche AN, Diwan AD, Chandra SR (2016) Flavonoids: an overview. J Nutr Sci 5:e47. https:\/\/doi.org\/10.1017\/jns.2016.41","journal-title":"J Nutr Sci"},{"issue":"4","key":"4321_CR25","doi-asserted-by":"publisher","first-page":"814","DOI":"10.3390\/molecules23040814","volume":"23","author":"G Hussain","year":"2018","unstructured":"Hussain G, Zhang L, Rasul A, Anwar H, Sohail MU, Razzaq A, Aziz N, Shabbir A et al (2018) Role of plant-derived flavonoids and their mechanism in attenuation of Alzheimer\u2019s and Parkinson\u2019s diseases: an update of recent data. Molecules 23(4):814. https:\/\/doi.org\/10.3390\/molecules23040814","journal-title":"Molecules"},{"key":"4321_CR26","doi-asserted-by":"publisher","first-page":"145345","DOI":"10.1155\/2013\/145345","volume":"2013","author":"XY Choo","year":"2013","unstructured":"Choo XY, Alukaidey L, White AR, Grubman A (2013) Neuroinflammation and copper in Alzheimer\u2019s disease. Int J Alzheimers Dis 2013:145345. https:\/\/doi.org\/10.1155\/2013\/145345","journal-title":"Int J Alzheimers Dis"},{"issue":"2","key":"4321_CR27","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1111\/fcp.12110","volume":"29","author":"A Prakash","year":"2015","unstructured":"Prakash A, Bharti K, Majeed AB (2015) Zinc: indications in brain disorders. Fundam Clin Pharmacol 29(2):131\u2013149. https:\/\/doi.org\/10.1111\/fcp.12110","journal-title":"Fundam Clin Pharmacol"},{"issue":"11","key":"4321_CR28","doi-asserted-by":"publisher","first-page":"863","DOI":"10.1038\/nrn1537","volume":"5","author":"L Zecca","year":"2004","unstructured":"Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5(11):863\u2013873. https:\/\/doi.org\/10.1038\/nrn1537","journal-title":"Nat Rev Neurosci"},{"key":"4321_CR29","doi-asserted-by":"publisher","first-page":"491597","DOI":"10.4061\/2011\/491597","volume":"2011","author":"A Takeda","year":"2010","unstructured":"Takeda A (2010) Insight into glutamate excitotoxicity from synaptic zinc homeostasis. Int J Alzheimers Dis 2011:491597. https:\/\/doi.org\/10.4061\/2011\/491597","journal-title":"Int J Alzheimers Dis"},{"issue":"1","key":"4321_CR30","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1016\/j.jsb.2005.09.004","volume":"155","author":"LM Miller","year":"2006","unstructured":"Miller LM, Wang Q, Telivala TP, Smith RJ, Lanzirotti A, Miklossy J (2006) Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer\u2019s disease. J Struct Biol 155(1):30\u201337. https:\/\/doi.org\/10.1016\/j.jsb.2005.09.004","journal-title":"J Struct Biol"},{"issue":"5","key":"4321_CR31","doi-asserted-by":"publisher","first-page":"386","DOI":"10.3390\/life11050386","volume":"11","author":"G Tassone","year":"2021","unstructured":"Tassone G, Kola A, Valensin D, Pozzi C (2021) Dynamic interplay between copper toxicity and mitochondrial dysfunction in Alzheimer\u2019s disease. Life (Basel) 11(5):386. https:\/\/doi.org\/10.3390\/life11050386","journal-title":"Life (Basel)"},{"key":"4321_CR32","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/978-3-319-60189-2_15","volume":"18","author":"DR Morris","year":"2017","unstructured":"Morris DR, Levenson CW (2017) Neurotoxicity of zinc. Adv Neurobiol 18:303\u2013312. https:\/\/doi.org\/10.1007\/978-3-319-60189-2_15","journal-title":"Adv Neurobiol"},{"key":"4321_CR33","doi-asserted-by":"publisher","first-page":"276","DOI":"10.3389\/fnmol.2018.00276","volume":"11","author":"SS Rao","year":"2018","unstructured":"Rao SS, Adlard PA (2018) Untangling tau and iron: exploring the interaction between iron and tau in neurodegeneration. Front Mol Neurosci 11:276. https:\/\/doi.org\/10.3389\/fnmol.2018.00276","journal-title":"Front Mol Neurosci"},{"key":"4321_CR34","doi-asserted-by":"publisher","first-page":"809","DOI":"10.17179\/excli2023-6335","volume":"22","author":"DP Kiouri","year":"2023","unstructured":"Kiouri DP, Tsoupra E, Peana M, Perlepes SP, Stefanidou ME, Chasapis CT (2023) Multifunctional role of zinc in human health: an update. EXCLI J 22:809\u2013827. https:\/\/doi.org\/10.17179\/excli2023-6335","journal-title":"EXCLI J"},{"issue":"5","key":"4321_CR35","doi-asserted-by":"publisher","first-page":"1443","DOI":"10.1007\/s00204-020-02702-9","volume":"94","author":"CT Chasapis","year":"2020","unstructured":"Chasapis CT, Ntoupa PA, Spiliopoulou CA, Stefanidou ME (2020) Recent aspects of the effects of zinc on human health. Arch Toxicol 94(5):1443\u20131460. https:\/\/doi.org\/10.1007\/s00204-020-02702-9","journal-title":"Arch Toxicol"},{"issue":"1","key":"4321_CR36","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1021\/pr050361j","volume":"5","author":"C Andreini","year":"2006","unstructured":"Andreini C, Banci L, Bertini I, Rosato A (2006) Counting the zinc-proteins encoded in the human genome. J Proteome Res 5(1):196\u2013201. https:\/\/doi.org\/10.1021\/pr050361j","journal-title":"J Proteome Res"},{"issue":"4","key":"4321_CR37","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00204-011-0775-1","volume":"86","author":"CT Chasapis","year":"2012","unstructured":"Chasapis CT, Loutsidou AC, Spiliopoulou CA, Stefanidou ME (2012) Zinc and human health: an update. Arch Toxicol 86(4):521\u2013534. https:\/\/doi.org\/10.1007\/s00204-011-0775-1","journal-title":"Arch Toxicol"},{"key":"4321_CR38","doi-asserted-by":"publisher","unstructured":"Portbury SD, Adlard PA (2017) Zinc signal in brain diseases. Int J Mol Sci 18(12). https:\/\/doi.org\/10.3390\/ijms18122506","DOI":"10.3390\/ijms18122506"},{"key":"4321_CR39","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1016\/j.taap.2018.12.018","volume":"364","author":"Z Qi","year":"2019","unstructured":"Qi Z, Liu KJ (2019) The interaction of zinc and the blood-brain barrier under physiological and ischemic conditions. Toxicol Appl Pharmacol 364:114\u2013119. https:\/\/doi.org\/10.1016\/j.taap.2018.12.018","journal-title":"Toxicol Appl Pharmacol"},{"issue":"12","key":"4321_CR40","doi-asserted-by":"publisher","first-page":"2526","DOI":"10.3390\/nu14122526","volume":"14","author":"J Willekens","year":"2022","unstructured":"Willekens J, Runnels LW (2022) Impact of zinc transport mechanisms on embryonic and brain development. Nutrients 14(12):2526. https:\/\/doi.org\/10.3390\/nu14122526","journal-title":"Nutrients"},{"issue":"9","key":"4321_CR41","doi-asserted-by":"publisher","first-page":"220188","DOI":"10.1098\/rsob.220188","volume":"12","author":"C Zhang","year":"2022","unstructured":"Zhang C, Dischler A, Glover K, Qin Y (2022) Neuronal signalling of zinc: from detection and modulation to function. Open Biol 12(9):220188. https:\/\/doi.org\/10.1098\/rsob.220188","journal-title":"Open Biol"},{"issue":"23","key":"4321_CR42","doi-asserted-by":"publisher","first-page":"8941","DOI":"10.3390\/ijms21238941","volume":"21","author":"S Choi","year":"2020","unstructured":"Choi S, Hong DK, Choi BY, Suh SW (2020) Zinc in the brain: friend or foe? Int J Mol Sci 21(23):8941. https:\/\/doi.org\/10.3390\/ijms21238941","journal-title":"Int J Mol Sci"},{"issue":"7","key":"4321_CR43","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1039\/c4mt00060a","volume":"6","author":"A Rembach","year":"2014","unstructured":"Rembach A, Hare DJ, Doecke JD, Burnham SC, Volitakis I, Fowler CJ, Cherny RA, McLean C et al (2014) Decreased serum zinc is an effect of ageing and not Alzheimer\u2019s disease. Metallomics 6(7):1216\u20131219. https:\/\/doi.org\/10.1039\/c4mt00060a","journal-title":"Metallomics"},{"issue":"3","key":"4321_CR44","first-page":"205","volume":"58","author":"M Idei","year":"2010","unstructured":"Idei M, Miyake K, Horiuchi Y, Tabe Y, Miyake N, Ikeda N, Miida T (2010) Serum zinc concentration decreases with age and is associated with anemia in middle-aged and elderly people. Rinsho Byori 58(3):205\u2013210","journal-title":"Rinsho Byori"},{"issue":"1","key":"4321_CR45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2006.11.023","volume":"177","author":"A Takeda","year":"2007","unstructured":"Takeda A, Tamano H, Kan F, Itoh H, Oku N (2007) Anxiety-like behavior of young rats after 2-week zinc deprivation. Behav Brain Res 177(1):1\u20136. https:\/\/doi.org\/10.1016\/j.bbr.2006.11.023","journal-title":"Behav Brain Res"},{"issue":"4","key":"4321_CR46","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1002\/jnr.10600","volume":"72","author":"A Takeda","year":"2003","unstructured":"Takeda A, Hirate M, Tamano H, Oku N (2003) Release of glutamate and GABA in the hippocampus under zinc deficiency. J Neurosci Res 72(4):537\u2013542. https:\/\/doi.org\/10.1002\/jnr.10600","journal-title":"J Neurosci Res"},{"key":"4321_CR47","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.5601\/jelem.2015.21.3.1045","volume":"21","author":"G \u00c7iftci","year":"2016","unstructured":"\u00c7iftci G, Cenesiz S, Ertekin A, Ormanc\u0131 N, S\u00f6\u011f\u00fct M\u00dc, Tuna E, Cenesiz M (2016) Curcumin abates formaldehyde-induced neurotoxicity via no pathway and the change of minerals (calcium, iron, zinc, copper, magnesium) in brain tissue. J Elem 21:1199\u20131209. https:\/\/doi.org\/10.5601\/jelem.2015.21.3.1045","journal-title":"J Elem"},{"key":"4321_CR48","doi-asserted-by":"publisher","unstructured":"Li Z, Liu Y, Wei R, Yong VW, Xue M (2023) The important role of zinc in neurological diseases. Biomolecules 13(1). https:\/\/doi.org\/10.3390\/biom13010028","DOI":"10.3390\/biom13010028"},{"issue":"6","key":"4321_CR49","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.pneurobio.2005.04.005","volume":"75","author":"E Mocchegiani","year":"2005","unstructured":"Mocchegiani E, Bertoni-Freddari C, Marcellini F, Malavolta M (2005) Brain, aging and neurodegeneration: role of zinc ion availability. Prog Neurobiol 75(6):367\u2013390. https:\/\/doi.org\/10.1016\/j.pneurobio.2005.04.005","journal-title":"Prog Neurobiol"},{"issue":"5","key":"4321_CR50","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1002\/jcb.22049","volume":"106","author":"RB Franklin","year":"2009","unstructured":"Franklin RB, Costello LC (2009) The important role of the apoptotic effects of zinc in the development of cancers. J Cell Biochem 106(5):750\u2013757. https:\/\/doi.org\/10.1002\/jcb.22049","journal-title":"J Cell Biochem"},{"issue":"3\u20134","key":"4321_CR51","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1006\/nbdi.1997.0163","volume":"4","author":"MP Cuajungco","year":"1997","unstructured":"Cuajungco MP, Lees GJ (1997) Zinc metabolism in the brain: relevance to human neurodegenerative disorders. Neurobiol Dis 4(3\u20134):137\u2013169. https:\/\/doi.org\/10.1006\/nbdi.1997.0163","journal-title":"Neurobiol Dis"},{"key":"4321_CR52","doi-asserted-by":"publisher","first-page":"920","DOI":"10.3389\/fnins.2019.00920","volume":"13","author":"NN Chen","year":"2019","unstructured":"Chen NN, Zhao DJ, Sun YX, Wang DD, Ni H (2019) Long-term effects of zinc deficiency and zinc supplementation on developmental seizure-induced brain damage and the underlying GPR39\/ZnT-3 and MBP expression in the hippocampus. Front Neurosci 13:920. https:\/\/doi.org\/10.3389\/fnins.2019.00920","journal-title":"Front Neurosci"},{"issue":"2","key":"4321_CR53","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1111\/j.1528-1157.1983.tb04876.x","volume":"24","author":"Y Pei","year":"1983","unstructured":"Pei Y, Zhao D, Huang J, Cao L (1983) Zinc-induced seizures: a new experimental model of epilepsy. Epilepsia 24(2):169\u2013176. https:\/\/doi.org\/10.1111\/j.1528-1157.1983.tb04876.x","journal-title":"Epilepsia"},{"key":"4321_CR54","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.pharmthera.2018.08.013","volume":"193","author":"U Doboszewska","year":"2019","unstructured":"Doboszewska U, Mlyniec K, Wlaz A, Poleszak E, Nowak G, Wlaz P (2019) Zinc signaling and epilepsy. Pharmacol Ther 193:156\u2013177. https:\/\/doi.org\/10.1016\/j.pharmthera.2018.08.013","journal-title":"Pharmacol Ther"},{"issue":"4","key":"4321_CR55","doi-asserted-by":"publisher","first-page":"870","DOI":"10.1111\/j.1528-1167.2008.01913.x","volume":"50","author":"SM Elsas","year":"2009","unstructured":"Elsas SM, Hazany S, Gregory WL, Mody I (2009) Hippocampal zinc infusion delays the development of afterdischarges and seizures in a kindling model of epilepsy. Epilepsia 50(4):870\u2013879. https:\/\/doi.org\/10.1111\/j.1528-1167.2008.01913.x","journal-title":"Epilepsia"},{"key":"4321_CR56","doi-asserted-by":"publisher","unstructured":"Liu X, Xiong X (2018) Copper. In: White WM (ed) Encyclopedia of geochemistry: a comprehensive reference source on the chemistry of the Earth. Springer International Publishing, Cham, pp 303\u2013305. https:\/\/doi.org\/10.1007\/978-3-319-39312-4_216","DOI":"10.1007\/978-3-319-39312-4_216"},{"key":"4321_CR57","doi-asserted-by":"publisher","unstructured":"Gromadzka G, Tarnacka B, Flaga A, Adamczyk A (2020) Copper dyshomeostasis in neurodegenerative diseases-therapeutic implications. Int J Mol Sci 21(23). https:\/\/doi.org\/10.3390\/ijms21239259","DOI":"10.3390\/ijms21239259"},{"key":"4321_CR58","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1186\/s40035-020-00189-z","volume":"9","author":"L Wang","year":"2020","unstructured":"Wang L, Yin YL, Liu XZ, Shen P, Zheng YG, Lan XR, Lu CB, Wang JZ (2020) Current understanding of metal ions in the pathogenesis of Alzheimer\u2019s disease. Transl Neurodegener 9:10. https:\/\/doi.org\/10.1186\/s40035-020-00189-z","journal-title":"Transl Neurodegener"},{"issue":"1","key":"4321_CR59","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/s41467-018-08280-w","volume":"10","author":"T Nagakubo","year":"2019","unstructured":"Nagakubo T, Kumano T, Ohta T, Hashimoto Y, Kobayashi M (2019) Copper amine oxidases catalyze the oxidative deamination and hydrolysis of cyclic imines. Nat Commun 10(1):413. https:\/\/doi.org\/10.1038\/s41467-018-08280-w","journal-title":"Nat Commun"},{"issue":"7","key":"4321_CR60","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.3390\/nu5072289","volume":"5","author":"G Vashchenko","year":"2013","unstructured":"Vashchenko G, MacGillivray RT (2013) Multi-copper oxidases and human iron metabolism. Nutrients 5(7):2289\u20132313. https:\/\/doi.org\/10.3390\/nu5072289","journal-title":"Nutrients"},{"issue":"4","key":"4321_CR61","doi-asserted-by":"publisher","first-page":"a005900","DOI":"10.1101\/cshperspect.a005900","volume":"8","author":"CH Heldin","year":"2016","unstructured":"Heldin CH, Lu B, Evans R, Gutkind JS (2016) Signals and receptors. Cold Spring Harb Perspect Biol 8(4):a005900. https:\/\/doi.org\/10.1101\/cshperspect.a005900","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"1","key":"4321_CR62","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/jnr.23143","volume":"91","author":"ED Gaier","year":"2013","unstructured":"Gaier ED, Eipper BA, Mains RE (2013) Copper signaling in the mammalian nervous system: synaptic effects. J Neurosci Res 91(1):2\u201319. https:\/\/doi.org\/10.1002\/jnr.23143","journal-title":"J Neurosci Res"},{"issue":"5","key":"4321_CR63","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1007\/s10534-005-5918-5","volume":"19","author":"KJ Allen","year":"2006","unstructured":"Allen KJ, Buck NE, Cheah DM, Gazeas S, Bhathal P, Mercer JF (2006) Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading. Biometals 19(5):555\u2013564. https:\/\/doi.org\/10.1007\/s10534-005-5918-5","journal-title":"Biometals"},{"issue":"4","key":"4321_CR64","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1080\/20009666.2017.1351289","volume":"7","author":"SM Wazir","year":"2017","unstructured":"Wazir SM, Ghobrial I (2017) Copper deficiency, a new triad: anemia, leucopenia, and myeloneuropathy. J Community Hosp Intern Med Perspect 7(4):265\u2013268. https:\/\/doi.org\/10.1080\/20009666.2017.1351289","journal-title":"J Community Hosp Intern Med Perspect"},{"issue":"1","key":"4321_CR65","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.yexcr.2016.08.003","volume":"347","author":"S Oe","year":"2016","unstructured":"Oe S, Miyagawa K, Honma Y, Harada M (2016) Copper induces hepatocyte injury due to the endoplasmic reticulum stress in cultured cells and patients with Wilson disease. Exp Cell Res 347(1):192\u2013200. https:\/\/doi.org\/10.1016\/j.yexcr.2016.08.003","journal-title":"Exp Cell Res"},{"key":"4321_CR66","doi-asserted-by":"publisher","first-page":"586209","DOI":"10.3389\/fnmol.2020.586209","volume":"13","author":"S Behl","year":"2020","unstructured":"Behl S, Mehta S, Pandey MK (2020) Abnormal levels of metal micronutrients and autism spectrum disorder: a perspective review. Front Mol Neurosci 13:586209. https:\/\/doi.org\/10.3389\/fnmol.2020.586209","journal-title":"Front Mol Neurosci"},{"issue":"3","key":"4321_CR67","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1080\/13547500902783747","volume":"14","author":"S Faber","year":"2009","unstructured":"Faber S, Zinn GM, Kern JC 2nd, Kingston HM (2009) The plasma zinc\/serum copper ratio as a biomarker in children with autism spectrum disorders. Biomarkers 14(3):171\u2013180. https:\/\/doi.org\/10.1080\/13547500902783747","journal-title":"Biomarkers"},{"issue":"5","key":"4321_CR68","doi-asserted-by":"publisher","first-page":"376","DOI":"10.3969\/j.issn.1673-5374.2012.05.009","volume":"7","author":"X Chen","year":"2012","unstructured":"Chen X, Guo C, Kong J (2012) Oxidative stress in neurodegenerative diseases. Neural Regen Res 7(5):376\u2013385. https:\/\/doi.org\/10.3969\/j.issn.1673-5374.2012.05.009","journal-title":"Neural Regen Res"},{"issue":"2","key":"4321_CR69","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1093\/toxsci\/kfy025","volume":"163","author":"HW Hsu","year":"2018","unstructured":"Hsu HW, Bondy SC, Kitazawa M (2018) Environmental and dietary exposure to copper and its cellular mechanisms linking to Alzheimer\u2019s disease. Toxicol Sci 163(2):338\u2013345. https:\/\/doi.org\/10.1093\/toxsci\/kfy025","journal-title":"Toxicol Sci"},{"issue":"4","key":"4321_CR70","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.niox.2012.07.002","volume":"27","author":"A Rossi-George","year":"2012","unstructured":"Rossi-George A, Guo CJ, Oakes BL, Gow AJ (2012) Copper modulates the phenotypic response of activated BV2 microglia through the release of nitric oxide. Nitric Oxide 27(4):201\u2013209. https:\/\/doi.org\/10.1016\/j.niox.2012.07.002","journal-title":"Nitric Oxide"},{"issue":"12","key":"4321_CR71","doi-asserted-by":"publisher","first-page":"10053","DOI":"10.3390\/nu7125513","volume":"7","author":"GJ Brewer","year":"2015","unstructured":"Brewer GJ (2015) Copper-2 ingestion, plus increased meat eating leading to increased copper absorption, are major factors behind the current epidemic of Alzheimer\u2019s disease. Nutrients 7(12):10053\u201310064. https:\/\/doi.org\/10.3390\/nu7125513","journal-title":"Nutrients"},{"issue":"4","key":"4321_CR72","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1080\/02773813.2010.542396","volume":"46","author":"GC Fang","year":"2011","unstructured":"Fang GC, Wu YS, Huang YL (2011) Measurement and modeling of concentrations of ambient air particles, chromium, copper and lead pollutants concentrations, as well as dry deposition in central Taiwan. J Environ Sci Health A Tox Hazard Subst Environ Eng 46(4):394\u2013407. https:\/\/doi.org\/10.1080\/02773813.2010.542396","journal-title":"J Environ Sci Health A Tox Hazard Subst Environ Eng"},{"issue":"35","key":"4321_CR73","doi-asserted-by":"publisher","first-page":"7190","DOI":"10.2174\/0929867328666210324161205","volume":"28","author":"M Peana","year":"2021","unstructured":"Peana M, Pelucelli A, Medici S, Cappai R, Nurchi VM, Zoroddu MA (2021) Metal toxicity and speciation: a review. Curr Med Chem 28(35):7190\u20137208. https:\/\/doi.org\/10.2174\/0929867328666210324161205","journal-title":"Curr Med Chem"},{"key":"4321_CR74","unstructured":"Dorsey A, Ingerman L (2004) Toxicological profile for copper."},{"issue":"9","key":"4321_CR75","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/j.tins.2009.05.009","volume":"32","author":"ML Block","year":"2009","unstructured":"Block ML, Calderon-Garciduenas L (2009) Air pollution: mechanisms of neuroinflammation and CNS disease. Trends Neurosci 32(9):506\u2013516. https:\/\/doi.org\/10.1016\/j.tins.2009.05.009","journal-title":"Trends Neurosci"},{"issue":"1","key":"4321_CR76","doi-asserted-by":"publisher","first-page":"e0170749","DOI":"10.1371\/journal.pone.0170749","volume":"12","author":"W Goch","year":"2017","unstructured":"Goch W, Bal W (2017) Numerical simulations reveal randomness of Cu(II) induced abeta peptide dimerization under conditions present in glutamatergic synapses. PLoS ONE 12(1):e0170749. https:\/\/doi.org\/10.1371\/journal.pone.0170749","journal-title":"PLoS ONE"},{"issue":"9","key":"4321_CR77","doi-asserted-by":"publisher","first-page":"1477","DOI":"10.1021\/cb300323q","volume":"7","author":"PA Frey","year":"2012","unstructured":"Frey PA, Reed GH (2012) The ubiquity of iron. ACS Chem Biol 7(9):1477\u20131481. https:\/\/doi.org\/10.1021\/cb300323q","journal-title":"ACS Chem Biol"},{"key":"4321_CR78","doi-asserted-by":"publisher","unstructured":"Briguglio M, Hrelia S, Malaguti M, Lombardi G, Riso P, Porrini M, Perazzo P, Banfi G (2020) The central role of iron in human nutrition: from folk to contemporary medicine. Nutrients 12(6). https:\/\/doi.org\/10.3390\/nu12061761","DOI":"10.3390\/nu12061761"},{"issue":"1","key":"4321_CR79","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12031-019-01276-1","volume":"68","author":"L Pivina","year":"2019","unstructured":"Pivina L, Semenova Y, Dosa MD, Dauletyarova M, Bjorklund G (2019) Iron deficiency, cognitive functions, and neurobehavioral disorders in children. J Mol Neurosci 68(1):1\u201310. https:\/\/doi.org\/10.1007\/s12031-019-01276-1","journal-title":"J Mol Neurosci"},{"key":"4321_CR80","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.2147\/NDT.S72491","volume":"10","author":"I Jauregui-Lobera","year":"2014","unstructured":"Jauregui-Lobera I (2014) Iron deficiency and cognitive functions. Neuropsychiatr Dis Treat 10:2087\u20132095. https:\/\/doi.org\/10.2147\/NDT.S72491","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"4","key":"4321_CR81","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/nure.12102","volume":"72","author":"EL Prado","year":"2014","unstructured":"Prado EL, Dewey KG (2014) Nutrition and brain development in early life. Nutr Rev 72(4):267\u2013284. https:\/\/doi.org\/10.1111\/nure.12102","journal-title":"Nutr Rev"},{"issue":"5","key":"4321_CR82","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/j.molcel.2011.09.021","volume":"44","author":"N Sanvisens","year":"2011","unstructured":"Sanvisens N, Bano MC, Huang M, Puig S (2011) Regulation of ribonucleotide reductase in response to iron deficiency. Mol Cell 44(5):759\u2013769. https:\/\/doi.org\/10.1016\/j.molcel.2011.09.021","journal-title":"Mol Cell"},{"issue":"3","key":"4321_CR83","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00204-020-02652-2","volume":"94","author":"G Bjorklund","year":"2020","unstructured":"Bjorklund G, Dadar M, Peana M, Rahaman MS, Aaseth J (2020) Interactions between iron and manganese in neurotoxicity. Arch Toxicol 94(3):725\u2013734. https:\/\/doi.org\/10.1007\/s00204-020-02652-2","journal-title":"Arch Toxicol"},{"issue":"9","key":"4321_CR84","doi-asserted-by":"publisher","first-page":"685","DOI":"10.2165\/00002512-200118090-00004","volume":"18","author":"B Halliwell","year":"2001","unstructured":"Halliwell B (2001) Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment. Drugs Aging 18(9):685\u2013716. https:\/\/doi.org\/10.2165\/00002512-200118090-00004","journal-title":"Drugs Aging"},{"issue":"5","key":"4321_CR85","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.freeradbiomed.2008.11.008","volume":"46","author":"B Halliwell","year":"2009","unstructured":"Halliwell B (2009) The wanderings of a free radical. Free Radic Biol Med 46(5):531\u2013542. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2008.11.008","journal-title":"Free Radic Biol Med"},{"issue":"37","key":"4321_CR86","doi-asserted-by":"publisher","first-page":"28812","DOI":"10.1074\/jbc.M110.126664","volume":"285","author":"ML Hegde","year":"2010","unstructured":"Hegde ML, Hegde PM, Holthauzen LM, Hazra TK, Rao KS, Mitra S (2010) Specific inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases. J Biol Chem 285(37):28812\u201328825. https:\/\/doi.org\/10.1074\/jbc.M110.126664","journal-title":"J Biol Chem"},{"issue":"8","key":"4321_CR87","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.2174\/0929867327999200917150652","volume":"28","author":"A Gasmi","year":"2021","unstructured":"Gasmi A, Chirumbolo S, Peana M, Mujawdiya PK, Dadar M, Menzel A, Bjorklund G (2021) Biomarkers of senescence during aging as possible warnings to use preventive measures. Curr Med Chem 28(8):1471\u20131488. https:\/\/doi.org\/10.2174\/0929867327999200917150652","journal-title":"Curr Med Chem"},{"key":"4321_CR88","doi-asserted-by":"publisher","first-page":"36669","DOI":"10.1038\/srep36669","volume":"6","author":"JY Wang","year":"2016","unstructured":"Wang JY, Zhuang QQ, Zhu LB, Zhu H, Li T, Li R, Chen SF, Huang CP, Zhang X, Zhu JH (2016) Meta-analysis of brain iron levels of Parkinson\u2019s disease patients determined by postmortem and MRI measurements. Sci Rep 6:36669. https:\/\/doi.org\/10.1038\/srep36669","journal-title":"Sci Rep"},{"issue":"2","key":"4321_CR89","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.cell.2019.12.035","volume":"180","author":"CE Hughes","year":"2020","unstructured":"Hughes CE, Coody TK, Jeong MY, Berg JA, Winge DR, Hughes AL (2020) Cysteine toxicity drives age-related mitochondrial decline by altering iron homeostasis. Cell 180(2):296-310 e218. https:\/\/doi.org\/10.1016\/j.cell.2019.12.035","journal-title":"Cell"},{"issue":"11","key":"4321_CR90","doi-asserted-by":"publisher","first-page":"1293","DOI":"10.1093\/abbs\/gmaa115","volume":"52","author":"L Wang","year":"2020","unstructured":"Wang L, Zhou Q, Chen L, Jiang J (2020) Iron-mediated lysosomal-mitochondrial crosstalk: a new direction in the treatment of aging and aging-related diseases. Acta Biochim Biophys Sin (Shanghai) 52(11):1293\u20131295. https:\/\/doi.org\/10.1093\/abbs\/gmaa115","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"issue":"2","key":"4321_CR91","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1148\/radiol.2532082324","volume":"253","author":"WZ Zhu","year":"2009","unstructured":"Zhu WZ, Zhong WD, Wang W, Zhan CJ, Wang CY, Qi JP, Wang JZ, Lei T (2009) Quantitative MR phase-corrected imaging to investigate increased brain iron deposition of patients with Alzheimer disease. Radiology 253(2):497\u2013504. https:\/\/doi.org\/10.1148\/radiol.2532082324","journal-title":"Radiology"},{"issue":"2","key":"4321_CR92","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/s11682-008-9059-7","volume":"3","author":"EV Sullivan","year":"2009","unstructured":"Sullivan EV, Adalsteinsson E, Rohlfing T, Pfefferbaum A (2009) Relevance of iron deposition in deep gray matter brain structures to cognitive and motor performance in healthy elderly men and women: exploratory findings. Brain Imaging Behav 3(2):167\u2013175. https:\/\/doi.org\/10.1007\/s11682-008-9059-7","journal-title":"Brain Imaging Behav"},{"issue":"1","key":"4321_CR93","doi-asserted-by":"publisher","first-page":"51","DOI":"10.4155\/fmc.09.140","volume":"2","author":"E Mills","year":"2010","unstructured":"Mills E, Dong XP, Wang F, Xu H (2010) Mechanisms of brain iron transport: insight into neurodegeneration and CNS disorders. Future Med Chem 2(1):51\u201364. https:\/\/doi.org\/10.4155\/fmc.09.140","journal-title":"Future Med Chem"},{"issue":"4","key":"4321_CR94","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.3233\/JAD-161143","volume":"60","author":"S van Duijn","year":"2017","unstructured":"van Duijn S, Bulk M, van Duinen SG, Nabuurs RJA, van Buchem MA, van der Weerd L, Natte R (2017) Cortical iron reflects severity of Alzheimer\u2019s disease. J Alzheimers Dis 60(4):1533\u20131545. https:\/\/doi.org\/10.3233\/JAD-161143","journal-title":"J Alzheimers Dis"},{"key":"4321_CR95","doi-asserted-by":"publisher","unstructured":"Rogers JT, Xia N, Wong A, Bakshi R, Cahill CM (2019) Targeting the iron-response elements of the mRNAs for the Alzheimer\u2019s amyloid precursor protein and ferritin to treat acute lead and manganese neurotoxicity. Int J Mol Sci 20(4). https:\/\/doi.org\/10.3390\/ijms20040994","DOI":"10.3390\/ijms20040994"},{"issue":"8","key":"4321_CR96","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1007\/s00775-019-01723-9","volume":"24","author":"S Warmlander","year":"2019","unstructured":"Warmlander S, Osterlund N, Wallin C, Wu J, Luo J, Tiiman A, Jarvet J, Graslund A (2019) Metal binding to the amyloid-beta peptides in the presence of biomembranes: potential mechanisms of cell toxicity. J Biol Inorg Chem 24(8):1189\u20131196. https:\/\/doi.org\/10.1007\/s00775-019-01723-9","journal-title":"J Biol Inorg Chem"},{"issue":"2","key":"4321_CR97","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3233\/jad-2004-6208","volume":"6","author":"G Casadesus","year":"2004","unstructured":"Casadesus G, Smith MA, Zhu X, Aliev G, Cash AD, Honda K, Petersen RB, Perry G (2004) Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species. J Alzheimers Dis 6(2):165\u2013169. https:\/\/doi.org\/10.3233\/jad-2004-6208","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"4321_CR98","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/j.arr.2004.01.003","volume":"3","author":"D Kaur","year":"2004","unstructured":"Kaur D, Andersen J (2004) Does cellular iron dysregulation play a causative role in Parkinson\u2019s disease? Ageing Res Rev 3(3):327\u2013343. https:\/\/doi.org\/10.1016\/j.arr.2004.01.003","journal-title":"Ageing Res Rev"},{"issue":"4","key":"4321_CR99","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/s1474-4422(03)00353-3","volume":"2","author":"Y Ke","year":"2003","unstructured":"Ke Y, Ming Qian Z (2003) Iron misregulation in the brain: a primary cause of neurodegenerative disorders. Lancet Neurol 2(4):246\u2013253. https:\/\/doi.org\/10.1016\/s1474-4422(03)00353-3","journal-title":"Lancet Neurol"},{"issue":"4","key":"4321_CR100","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1097\/01.wco.0000137534.61244.d1","volume":"17","author":"M Thomas","year":"2004","unstructured":"Thomas M, Jankovic J (2004) Neurodegenerative disease and iron storage in the brain. Curr Opin Neurol 17(4):437\u2013442. https:\/\/doi.org\/10.1097\/01.wco.0000137534.61244.d1","journal-title":"Curr Opin Neurol"},{"key":"4321_CR101","doi-asserted-by":"publisher","first-page":"101877","DOI":"10.1016\/j.redox.2021.101877","volume":"41","author":"VK Wandt","year":"2021","unstructured":"Wandt VK, Winkelbeiner N, Bornhorst J, Witt B, Raschke S, Simon L, Ebert F, Kipp AP, Schwerdtle T (2021) A matter of concern - trace element dyshomeostasis and genomic stability in neurons. Redox Biol 41:101877. https:\/\/doi.org\/10.1016\/j.redox.2021.101877","journal-title":"Redox Biol"},{"issue":"1","key":"4321_CR102","doi-asserted-by":"publisher","first-page":"13","DOI":"10.15171\/apb.2020.002","volume":"10","author":"M Mashhadi Akbar Boojar","year":"2020","unstructured":"Mashhadi Akbar Boojar M (2020) An overview of the cellular mechanisms of flavonoids radioprotective effects. Adv Pharm Bull 10(1):13\u201319. https:\/\/doi.org\/10.15171\/apb.2020.002","journal-title":"Adv Pharm Bull"},{"issue":"2","key":"4321_CR103","doi-asserted-by":"publisher","first-page":"62","DOI":"10.15673\/fst.v14i3.1797","volume":"14","author":"P Oliinyk","year":"2020","unstructured":"Oliinyk P, Voronenko D, Lysiuk R (2020) Radioprotective properties of polyphenolic compounds of edible and aromatic plants. Food Sci Technol 14(2):62\u201372. https:\/\/doi.org\/10.15673\/fst.v14i3.1797","journal-title":"Food Sci Technol"},{"key":"4321_CR104","unstructured":"Keller RB (2009) Flavonoids: Biosynthesis, biological effects and dietary sources. Nova Science Publishers"},{"issue":"4","key":"4321_CR105","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1039\/b311404j","volume":"21","author":"CA Williams","year":"2004","unstructured":"Williams CA, Grayer RJ (2004) Anthocyanins and other flavonoids. Nat Prod Rep 21(4):539\u2013573. https:\/\/doi.org\/10.1039\/b311404j","journal-title":"Nat Prod Rep"},{"key":"4321_CR106","first-page":"6697","volume":"5","author":"A Ghasemzadeh","year":"2011","unstructured":"Ghasemzadeh A, Ghasemzadeh N (2011) Flavonoids and phenolic acids: role and biochemical activity in plants and human. J Med Plants Res 5:6697\u20136703","journal-title":"J Med Plants Res"},{"issue":"2","key":"4321_CR107","doi-asserted-by":"publisher","first-page":"108","DOI":"10.5281\/zenodo.545778","volume":"7","author":"KM Brodowska","year":"2017","unstructured":"Brodowska KM (2017) Natural flavonoids: classification, potential role, and application of flavonoid analogues. Eur J Biol Res 7(2):108\u2013123. https:\/\/doi.org\/10.5281\/zenodo.545778","journal-title":"Eur J Biol Res"},{"key":"4321_CR108","doi-asserted-by":"publisher","unstructured":"Chirumbolo S, Bjorklund G, Lysiuk R, Vella A, Lenchyk L, Upyr T (2018) Targeting cancer with phytochemicals via their fine tuning of the cell survival signaling pathways. Int J Mol Sci 19(11). https:\/\/doi.org\/10.3390\/ijms19113568","DOI":"10.3390\/ijms19113568"},{"key":"4321_CR109","doi-asserted-by":"publisher","unstructured":"Gasmi A, Mujawdiya PK, Noor S, Lysiuk R, Darmohray R, Piscopo S, Lenchyk L, Antonyak H et al (2022) Polyphenols in metabolic diseases. Molecules 27(19). https:\/\/doi.org\/10.3390\/molecules27196280","DOI":"10.3390\/molecules27196280"},{"key":"4321_CR110","doi-asserted-by":"publisher","unstructured":"Rees A, Dodd GF, Spencer JPE (2018) The effects of flavonoids on cardiovascular health: a review of human intervention trials and implications for cerebrovascular function. Nutrients 10(12). https:\/\/doi.org\/10.3390\/nu10121852","DOI":"10.3390\/nu10121852"},{"key":"4321_CR111","doi-asserted-by":"publisher","unstructured":"Suen J, Thomas J, Kranz A, Vun S, Miller M (2016) Effect of flavonoids on oxidative stress and inflammation in adults at risk of cardiovascular disease: a systematic review. Healthcare (Basel) 4(3). https:\/\/doi.org\/10.3390\/healthcare4030069","DOI":"10.3390\/healthcare4030069"},{"key":"4321_CR112","doi-asserted-by":"publisher","unstructured":"Lysiuk R, Oliynyk P, Antonyak H, Voronenko D (2020) Development of phyto-antidotes against adverse chemical agents. In: Poisonous plants and phytochemicals in drug discovery. pp 249\u2013268. https:\/\/doi.org\/10.1002\/9781119650034.ch12","DOI":"10.1002\/9781119650034.ch12"},{"key":"4321_CR113","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1016\/j.fct.2017.10.039","volume":"110","author":"G Bjorklund","year":"2017","unstructured":"Bjorklund G, Dadar M, Chirumbolo S, Lysiuk R (2017) Flavonoids as detoxifying and pro-survival agents: what\u2019s new? Food Chem Toxicol 110:240\u2013250. https:\/\/doi.org\/10.1016\/j.fct.2017.10.039","journal-title":"Food Chem Toxicol"},{"issue":"13","key":"4321_CR114","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.2174\/1568026620666200416085330","volume":"20","author":"G Maan","year":"2020","unstructured":"Maan G, Sikdar B, Kumar A, Shukla R, Mishra A (2020) Role of flavonoids in neurodegenerative diseases: limitations and future perspectives. Curr Top Med Chem 20(13):1169\u20131194. https:\/\/doi.org\/10.2174\/1568026620666200416085330","journal-title":"Curr Top Med Chem"},{"key":"4321_CR115","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yclnex.2018.12.004","volume":"24","author":"S Maiti","year":"2019","unstructured":"Maiti S, Nazmeen A, Medda N, Patra R, Ghosh TK (2019) Flavonoids green tea against oxidant stress and inflammation with related human diseases. Clin Nutr Exp 24:1\u201314. https:\/\/doi.org\/10.1016\/j.yclnex.2018.12.004","journal-title":"Clin Nutr Exp"},{"key":"4321_CR116","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.ejmech.2017.09.001","volume":"153","author":"C Spagnuolo","year":"2018","unstructured":"Spagnuolo C, Moccia S, Russo GL (2018) Anti-inflammatory effects of flavonoids in neurodegenerative disorders. Eur J Med Chem 153:105\u2013115. https:\/\/doi.org\/10.1016\/j.ejmech.2017.09.001","journal-title":"Eur J Med Chem"},{"issue":"6","key":"4321_CR117","first-page":"2353","volume":"12","author":"J An","year":"2020","unstructured":"An J, Chen B, Kang X, Zhang R, Guo Y, Zhao J, Yang H (2020) Neuroprotective effects of natural compounds on LPS-induced inflammatory responses in microglia. Am J Transl Res 12(6):2353\u20132378","journal-title":"Am J Transl Res"},{"issue":"2","key":"4321_CR118","doi-asserted-by":"publisher","first-page":"167","DOI":"10.3233\/BPL-200098","volume":"6","author":"KL Hole","year":"2021","unstructured":"Hole KL, Williams RJ (2021) Flavonoids as an intervention for Alzheimer\u2019s disease: progress and hurdles towards defining a mechanism of action. Brain Plast 6(2):167\u2013192. https:\/\/doi.org\/10.3233\/BPL-200098","journal-title":"Brain Plast"},{"issue":"1","key":"4321_CR119","doi-asserted-by":"publisher","first-page":"81","DOI":"10.3233\/NHA-1615","volume":"4","author":"S Neshatdoust","year":"2016","unstructured":"Neshatdoust S, Saunders C, Castle SM, Vauzour D, Williams C, Butler L, Lovegrove JA, Spencer JP (2016) High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: two randomised, controlled trials. Nutr Healthy Aging 4(1):81\u201393. https:\/\/doi.org\/10.3233\/NHA-1615","journal-title":"Nutr Healthy Aging"},{"issue":"3","key":"4321_CR120","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1007\/s12263-007-0056-z","volume":"2","author":"JP Spencer","year":"2007","unstructured":"Spencer JP (2007) The interactions of flavonoids within neuronal signalling pathways. Genes Nutr 2(3):257\u2013273. https:\/\/doi.org\/10.1007\/s12263-007-0056-z","journal-title":"Genes Nutr"},{"issue":"2","key":"4321_CR121","doi-asserted-by":"publisher","first-page":"99","DOI":"10.3390\/biomedicines9020099","volume":"9","author":"S Devi","year":"2021","unstructured":"Devi S, Kumar V, Singh SK, Dubey AK, Kim JJ (2021) Flavonoids: potential candidates for the treatment of neurodegenerative disorders. Biomedicines 9(2):99. https:\/\/doi.org\/10.3390\/biomedicines9020099","journal-title":"Biomedicines"},{"key":"4321_CR122","doi-asserted-by":"publisher","unstructured":"Maher P (2019) The potential of flavonoids for the treatment of neurodegenerative diseases. Int J Mol Sci 20(12). https:\/\/doi.org\/10.3390\/ijms20123056","DOI":"10.3390\/ijms20123056"},{"issue":"15","key":"4321_CR123","doi-asserted-by":"publisher","first-page":"1138","DOI":"10.1212\/WNL.0b013e31824f7fc4","volume":"78","author":"X Gao","year":"2012","unstructured":"Gao X, Cassidy A, Schwarzschild MA, Rimm EB, Ascherio A (2012) Habitual intake of dietary flavonoids and risk of Parkinson disease. Neurology 78(15):1138\u20131145. https:\/\/doi.org\/10.1212\/WNL.0b013e31824f7fc4","journal-title":"Neurology"},{"issue":"11","key":"4321_CR124","doi-asserted-by":"publisher","first-page":"1631","DOI":"10.1007\/s00018-008-7452-4","volume":"65","author":"H Hatcher","year":"2008","unstructured":"Hatcher H, Planalp R, Cho J, Torti FM, Torti SV (2008) Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci 65(11):1631\u20131652. https:\/\/doi.org\/10.1007\/s00018-008-7452-4","journal-title":"Cell Mol Life Sci"},{"key":"4321_CR125","doi-asserted-by":"publisher","first-page":"7656919","DOI":"10.1155\/2020\/7656919","volume":"2020","author":"RS Ahmad","year":"2020","unstructured":"Ahmad RS, Hussain MB, Sultan MT, Arshad MS, Waheed M, Shariati MA, Plygun S, Hashempur MH (2020) Biochemistry, safety, pharmacological activities, and clinical applications of turmeric: a mechanistic review. Evid Based Complement Alternat Med 2020:7656919. https:\/\/doi.org\/10.1155\/2020\/7656919","journal-title":"Evid Based Complement Alternat Med"},{"issue":"12","key":"4321_CR126","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.2174\/1389557520666200414161316","volume":"20","author":"L Slika","year":"2020","unstructured":"Slika L, Patra D (2020) Traditional uses, therapeutic effects and recent advances of curcumin: a mini-review. Mini Rev Med Chem 20(12):1072\u20131082. https:\/\/doi.org\/10.2174\/1389557520666200414161316","journal-title":"Mini Rev Med Chem"},{"issue":"1","key":"4321_CR127","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1089\/107555303321223035","volume":"9","author":"N Chainani-Wu","year":"2003","unstructured":"Chainani-Wu N (2003) Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med 9(1):161\u2013168. https:\/\/doi.org\/10.1089\/107555303321223035","journal-title":"J Altern Complement Med"},{"issue":"2","key":"4321_CR128","first-page":"128","volume":"11","author":"K Spelman","year":"2006","unstructured":"Spelman K, Burns J, Nichols D, Winters N, Ottersberg S, Tenborg M (2006) Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators. Altern Med Rev 11(2):128\u2013150","journal-title":"Altern Med Rev"},{"key":"4321_CR129","doi-asserted-by":"publisher","first-page":"01021","DOI":"10.3389\/fphar.2020.01021","volume":"11","author":"J Sharifi-Rad","year":"2020","unstructured":"Sharifi-Rad J, Rayess YE, Rizk AA, Sadaka C, Zgheib R, Zam W, Sestito S, Rapposelli S et al (2020) Turmeric and its major compound curcumin on health: bioactive effects and safety profiles for food, pharmaceutical, biotechnological and medicinal applications. Front Pharmacol 11:01021. https:\/\/doi.org\/10.3389\/fphar.2020.01021","journal-title":"Front Pharmacol"},{"issue":"22","key":"4321_CR130","doi-asserted-by":"publisher","first-page":"5308","DOI":"10.1002\/anie.201107724","volume":"51","author":"T Esatbeyoglu","year":"2012","unstructured":"Esatbeyoglu T, Huebbe P, Ernst IM, Chin D, Wagner AE, Rimbach G (2012) Curcumin\u2013from molecule to biological function. Angew Chem Int Ed Engl 51(22):5308\u20135332. https:\/\/doi.org\/10.1002\/anie.201107724","journal-title":"Angew Chem Int Ed Engl"},{"key":"4321_CR131","doi-asserted-by":"publisher","unstructured":"Wiggers HJ, Zaioncz S, Cheleski J, Mainardes RM, Khalil NM (2017) Chapter 7 - Curcumin, a multitarget phytochemical: challenges and perspectives. In: Atta ur R (ed) Studies in Natural Products Chemistry, vol 53. Elsevier, pp 243\u2013276. https:\/\/doi.org\/10.1016\/B978-0-444-63930-1.00007-7","DOI":"10.1016\/B978-0-444-63930-1.00007-7"},{"issue":"1","key":"4321_CR132","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","volume":"41","author":"BB Aggarwal","year":"2009","unstructured":"Aggarwal BB, Harikumar KB (2009) Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int J Biochem Cell Biol 41(1):40\u201359. https:\/\/doi.org\/10.1016\/j.biocel.2008.06.010","journal-title":"Int J Biochem Cell Biol"},{"issue":"4","key":"4321_CR133","doi-asserted-by":"publisher","first-page":"338","DOI":"10.2174\/1570159X11311040002","volume":"11","author":"WH Lee","year":"2013","unstructured":"Lee WH, Loo CY, Bebawy M, Luk F, Mason RS, Rohanizadeh R (2013) Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol 11(4):338\u2013378. https:\/\/doi.org\/10.2174\/1570159X11311040002","journal-title":"Curr Neuropharmacol"},{"key":"4321_CR134","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.jinorgbio.2015.08.011","volume":"151","author":"JI Lachowicz","year":"2015","unstructured":"Lachowicz JI, Nurchi VM, Crisponi G, Jaraquemada-PelaezMde G, Ostrowska M, Jezierska J, Gumienna-Kontecka E, Peana M et al (2015) Zinc(II) and copper(II) complexes with hydroxypyrone iron chelators. J Inorg Biochem 151:94\u2013106. https:\/\/doi.org\/10.1016\/j.jinorgbio.2015.08.011","journal-title":"J Inorg Biochem"},{"issue":"43","key":"4321_CR135","doi-asserted-by":"publisher","first-page":"16167","DOI":"10.1039\/c9dt02905b","volume":"48","author":"VM Nurchi","year":"2019","unstructured":"Nurchi VM, Cappai R, Chand K, Chaves S, Gano L, Crisponi G, Peana M, Zoroddu MA et al (2019) New strong extrafunctionalizable tris(3,4-HP) and bis(3,4-HP) metal sequestering agents: synthesis, solution and in vivo metal chelation. Dalton Trans 48(43):16167\u201316183. https:\/\/doi.org\/10.1039\/c9dt02905b","journal-title":"Dalton Trans"},{"key":"4321_CR136","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.jinorgbio.2019.01.012","volume":"193","author":"VM Nurchi","year":"2019","unstructured":"Nurchi VM, de Guadalupe J-P, Crisponi G, Lachowicz JI, Cappai R, Gano L, Santos MA, Melchior A et al (2019) A new tripodal kojic acid derivative for iron sequestration: synthesis, protonation, complex formation studies with Fe(3+), Al(3+), Cu(2+) and Zn(2+), and in vivo bioassays. J Inorg Biochem 193:152\u2013165. https:\/\/doi.org\/10.1016\/j.jinorgbio.2019.01.012","journal-title":"J Inorg Biochem"},{"key":"4321_CR137","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.jinorgbio.2017.03.001","volume":"171","author":"M Peana","year":"2017","unstructured":"Peana M, Medici S, Nurchi VM, Lachowicz JI, Crisponi G, Garribba E, Sanna D, Zoroddu MA (2017) Interaction of a chelating agent, 5-hydroxy-2-(hydroxymethyl)pyridin-4(1H)-one, with Al(III), Cu(II) and Zn(II) ions. J Inorg Biochem 171:18\u201328. https:\/\/doi.org\/10.1016\/j.jinorgbio.2017.03.001","journal-title":"J Inorg Biochem"},{"key":"4321_CR138","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ccr.2014.04.023","volume":"284","author":"G Crisponi","year":"2015","unstructured":"Crisponi G, Nurchi VM, Lachowicz JI, Crespo-Alonso M, Zoroddu MA, Peana M (2015) Kill or cure: misuse of chelation therapy for human diseases. Coord Chem Rev 284:278\u2013285. https:\/\/doi.org\/10.1016\/j.ccr.2014.04.023","journal-title":"Coord Chem Rev"},{"issue":"4","key":"4321_CR139","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1755-5949.2010.00149.x","volume":"17","author":"BF Popescu","year":"2011","unstructured":"Popescu BF, Nichol H (2011) Mapping brain metals to evaluate therapies for neurodegenerative disease. CNS Neurosci Ther 17(4):256\u2013268. https:\/\/doi.org\/10.1111\/j.1755-5949.2010.00149.x","journal-title":"CNS Neurosci Ther"},{"issue":"4","key":"4321_CR140","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1002\/med.20148","volume":"29","author":"S Bolognin","year":"2009","unstructured":"Bolognin S, Drago D, Messori L, Zatta P (2009) Chelation therapy for neurodegenerative diseases. Med Res Rev 29(4):547\u2013570. https:\/\/doi.org\/10.1002\/med.20148","journal-title":"Med Res Rev"},{"issue":"6","key":"4321_CR141","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/bcpt.12972","volume":"122","author":"G Bjorklund","year":"2018","unstructured":"Bjorklund G, Dadar M, Martins N, Chirumbolo S, Goh BH, Smetanina K, Lysiuk R (2018) Brief challenges on medicinal plants: an eye-opening look at ageing-related disorders. Basic Clin Pharmacol Toxicol 122(6):539\u2013558. https:\/\/doi.org\/10.1111\/bcpt.12972","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"4321_CR142","doi-asserted-by":"publisher","unstructured":"Winiarska-Mieczan A, Baranowska-W\u00f3jcik E, Kwiecie\u0144 M, Grela ER, Szwajgier D, Kwiatkowska K, Kiczorowska B (2020) The role of dietary antioxidants in the pathogenesis of neurodegenerative diseases and their impact on cerebral oxidoreductive balance. Nutrients 12(2). https:\/\/doi.org\/10.3390\/nu12020435","DOI":"10.3390\/nu12020435"},{"issue":"11","key":"4321_CR143","doi-asserted-by":"publisher","first-page":"6383","DOI":"10.1007\/s12035-023-03469-7","volume":"60","author":"Y Jiang","year":"2023","unstructured":"Jiang Y, Tang X, Deng P, Jiang C, He Y, Hao D, Yang H (2023) The neuroprotective role of fisetin in different neurological diseases: a systematic review. Mol Neurobiol 60(11):6383\u20136394. https:\/\/doi.org\/10.1007\/s12035-023-03469-7","journal-title":"Mol Neurobiol"},{"issue":"3","key":"4321_CR144","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1080\/1028415X.2020.1760531","volume":"25","author":"R Adami","year":"2022","unstructured":"Adami R, Bottai D (2022) Curcumin and neurological diseases. Nutr Neurosci 25(3):441\u2013461. https:\/\/doi.org\/10.1080\/1028415X.2020.1760531","journal-title":"Nutr Neurosci"},{"issue":"9","key":"4321_CR145","doi-asserted-by":"publisher","first-page":"2243","DOI":"10.1093\/jn\/130.9.2243","volume":"130","author":"Y Arai","year":"2000","unstructured":"Arai Y, Watanabe S, Kimira M, Shimoi K, Mochizuki R, Kinae N (2000) Dietary intakes of flavonols, flavones and isoflavones by Japanese women and the inverse correlation between quercetin intake and plasma LDL cholesterol concentration. J Nutr 130(9):2243\u20132250. https:\/\/doi.org\/10.1093\/jn\/130.9.2243","journal-title":"J Nutr"},{"issue":"4","key":"4321_CR146","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1111\/php.13213","volume":"96","author":"VA Munoz","year":"2020","unstructured":"Munoz VA, Dimarco Palencia FCD, Sancho MI, Miskoski S, Garcia NA, Ferrari GV, Montana MP (2020) Experimental and theoretical study of the stability of the complex fisetin-Cu(II) and a comparative study of free ligand and complex interaction with molecular singlet oxygen. Photochem Photobiol 96(4):815\u2013825. https:\/\/doi.org\/10.1111\/php.13213","journal-title":"Photochem Photobiol"},{"issue":"Pt A","key":"4321_CR147","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.ijbiomac.2018.08.162","volume":"120","author":"S Bhuiya","year":"2018","unstructured":"Bhuiya S, Chowdhury S, Haque L, Das S (2018) Spectroscopic, photophysical and theoretical insight into the chelation properties of fisetin with copper (II) in aqueous buffered solutions for calf thymus DNA binding. Int J Biol Macromol 120(Pt A):1156\u20131169. https:\/\/doi.org\/10.1016\/j.ijbiomac.2018.08.162","journal-title":"Int J Biol Macromol"},{"key":"4321_CR148","doi-asserted-by":"publisher","first-page":"118164","DOI":"10.1016\/j.molliq.2021.118164","volume":"349","author":"J Li","year":"2022","unstructured":"Li J, Zhu J, Wu H, Li W (2022) Synthesis, in vitro, and in silico studies of fisetin and quercetin and their metal complexes as inhibitors of \u03b1-glucosidase and thrombin. J Mol Liq 349:118164. https:\/\/doi.org\/10.1016\/j.molliq.2021.118164","journal-title":"J Mol Liq"},{"issue":"17","key":"4321_CR149","doi-asserted-by":"publisher","first-page":"4560","DOI":"10.1039\/c0dt01834a","volume":"40","author":"JM DimitricMarkovic","year":"2011","unstructured":"DimitricMarkovic JM, Markovic ZS, Brdaric TP, Filipovic ND (2011) Comparative spectroscopic and mechanistic study of chelation properties of fisetin with iron in aqueous buffered solutions. Implications on in vitro antioxidant activity. Dalton Trans 40(17):4560\u20134571. https:\/\/doi.org\/10.1039\/c0dt01834a","journal-title":"Dalton Trans"},{"issue":"2","key":"4321_CR150","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1089\/ars.2012.4901","volume":"19","author":"N Khan","year":"2013","unstructured":"Khan N, Syed DN, Ahmad N, Mukhtar H (2013) Fisetin: a dietary antioxidant for health promotion. Antioxid Redox Signal 19(2):151\u2013162. https:\/\/doi.org\/10.1089\/ars.2012.4901","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"4321_CR151","doi-asserted-by":"publisher","first-page":"155","DOI":"10.3233\/BPL-200104","volume":"6","author":"P Maher","year":"2021","unstructured":"Maher P (2021) Preventing and treating neurological disorders with the flavonol fisetin. Brain Plast 6(2):155\u2013166. https:\/\/doi.org\/10.3233\/BPL-200104","journal-title":"Brain Plast"},{"issue":"9","key":"4321_CR152","doi-asserted-by":"publisher","first-page":"3033","DOI":"10.1039\/c7fo00809k","volume":"8","author":"P Maher","year":"2017","unstructured":"Maher P (2017) Protective effects of fisetin and other berry flavonoids in Parkinson\u2019s disease. Food Funct 8(9):3033\u20133042. https:\/\/doi.org\/10.1039\/c7fo00809k","journal-title":"Food Funct"},{"issue":"1","key":"4321_CR153","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1080\/19390211.2019.1710646","volume":"18","author":"K Alikatte","year":"2021","unstructured":"Alikatte K, Palle S, Rajendra Kumar J, Pathakala N (2021) Fisetin improved rotenone-induced behavioral deficits, oxidative changes, and mitochondrial dysfunctions in rat model of Parkinson\u2019s disease. J Diet Suppl 18(1):57\u201371. https:\/\/doi.org\/10.1080\/19390211.2019.1710646","journal-title":"J Diet Suppl"},{"key":"4321_CR154","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.neuroscience.2018.03.008","volume":"379","author":"TH Wang","year":"2018","unstructured":"Wang TH, Wang SY, Wang XD, Jiang HQ, Yang YQ, Wang Y, Cheng JL, Zhang CT et al (2018) Fisetin exerts antioxidant and neuroprotective effects in multiple mutant hSOD1 models of amyotrophic lateral sclerosis by activating ERK. Neuroscience 379:152\u2013166. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.03.008","journal-title":"Neuroscience"},{"key":"4321_CR155","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.lfs.2017.11.004","volume":"193","author":"S Singh","year":"2018","unstructured":"Singh S, Singh AK, Garg G, Rizvi SI (2018) Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration. Life Sci 193:171\u2013179. https:\/\/doi.org\/10.1016\/j.lfs.2017.11.004","journal-title":"Life Sci"},{"key":"4321_CR156","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.ebiom.2018.09.015","volume":"36","author":"MJ Yousefzadeh","year":"2018","unstructured":"Yousefzadeh MJ, Zhu Y, McGowan SJ, Angelini L, Fuhrmann-Stroissnigg H, Xu M, Ling YY, Melos KI et al (2018) Fisetin is a senotherapeutic that extends health and lifespan. EBioMedicine 36:18\u201328. https:\/\/doi.org\/10.1016\/j.ebiom.2018.09.015","journal-title":"EBioMedicine"},{"key":"4321_CR157","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1016\/j.freeradbiomed.2017.11.015","volume":"115","author":"P Maher","year":"2018","unstructured":"Maher P (2018) Potentiation of glutathione loss and nerve cell death by the transition metals iron and copper: implications for age-related neurodegenerative diseases. Free Radic Biol Med 115:92\u2013104. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2017.11.015","journal-title":"Free Radic Biol Med"},{"key":"4321_CR158","doi-asserted-by":"publisher","unstructured":"Maher P (2020) Modulation of the neuroprotective and anti-inflammatory activities of the flavonol fisetin by the transition metals iron and copper. Antioxidants (Basel)9 (11). https:\/\/doi.org\/10.3390\/antiox9111113","DOI":"10.3390\/antiox9111113"},{"key":"4321_CR159","doi-asserted-by":"publisher","unstructured":"Ivanovic M, Makoter K, Islamcevic Razborsek M (2021) Comparative study of chemical composition and antioxidant activity of essential oils and crude extracts of four characteristic Zingiberaceae herbs. Plants (Basel) 10(3). https:\/\/doi.org\/10.3390\/plants10030501","DOI":"10.3390\/plants10030501"},{"issue":"12","key":"4321_CR160","doi-asserted-by":"publisher","first-page":"20091","DOI":"10.3390\/molecules191220091","volume":"19","author":"KI Priyadarsini","year":"2014","unstructured":"Priyadarsini KI (2014) The chemistry of curcumin: from extraction to therapeutic agent. Molecules 19(12):20091\u201320112. https:\/\/doi.org\/10.3390\/molecules191220091","journal-title":"Molecules"},{"issue":"1","key":"4321_CR161","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0021-9673(98)00540-8","volume":"818","author":"X-G He","year":"1998","unstructured":"He X-G, Lin L-Z, Lian L-Z, Lindenmaier M (1998) Liquid chromatography\u2013electrospray mass spectrometric analysis of curcuminoids and sesquiterpenoids in turmeric (Curcuma longa). J Chromatogr A 818(1):127\u2013132. https:\/\/doi.org\/10.1016\/S0021-9673(98)00540-8","journal-title":"J Chromatogr A"},{"issue":"2","key":"4321_CR162","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.jphotochemrev.2009.05.001","volume":"10","author":"KI Priyadarsini","year":"2009","unstructured":"Priyadarsini KI (2009) Photophysics, photochemistry and photobiology of curcumin: studies from organic solutions, bio-mimetics and living cells. J Photochem Photobiol C 10(2):81\u201395. https:\/\/doi.org\/10.1016\/j.jphotochemrev.2009.05.001","journal-title":"J Photochem Photobiol C"},{"issue":"10","key":"4321_CR163","doi-asserted-by":"publisher","first-page":"8098","DOI":"10.1039\/C7NJ04223J","volume":"42","author":"N Bicer","year":"2018","unstructured":"Bicer N, Yildiz E, Yegani AA, Aksu F (2018) Synthesis of curcumin complexes with iron(iii) and manganese(ii), and effects of curcumin\u2013iron(iii) on Alzheimer\u2019s disease. New J Chem 42(10):8098\u20138104. https:\/\/doi.org\/10.1039\/C7NJ04223J","journal-title":"New J Chem"},{"issue":"4","key":"4321_CR164","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.ejmech.2006.11.012","volume":"42","author":"A Barik","year":"2007","unstructured":"Barik A, Mishra B, Kunwar A, Kadam RM, Shen L, Dutta S, Padhye S, Satpati AK et al (2007) Comparative study of copper(II)-curcumin complexes as superoxide dismutase mimics and free radical scavengers. Eur J Med Chem 42(4):431\u2013439. https:\/\/doi.org\/10.1016\/j.ejmech.2006.11.012","journal-title":"Eur J Med Chem"},{"key":"4321_CR165","doi-asserted-by":"publisher","unstructured":"Prasad S, DuBourdieu D, Srivastava A, Kumar P, Lall R (2021) Metal-curcumin complexes in therapeutics: an approach to enhance pharmacological effects of curcumin. Int J Mol Sci 22(13). https:\/\/doi.org\/10.3390\/ijms22137094","DOI":"10.3390\/ijms22137094"},{"key":"4321_CR166","doi-asserted-by":"publisher","first-page":"982423","DOI":"10.1155\/2013\/982423","volume":"2013","author":"MI Khalil","year":"2013","unstructured":"Khalil MI, Al-Zahem AM, Al-Qunaibit MH (2013) Synthesis, characterization, Mossbauer parameters, and antitumor activity of Fe(III) curcumin complex. Bioinorg Chem Appl 2013:982423. https:\/\/doi.org\/10.1155\/2013\/982423","journal-title":"Bioinorg Chem Appl"},{"issue":"1","key":"4321_CR167","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0020-1693(01)00687-9","volume":"328","author":"M Borsari","year":"2002","unstructured":"Borsari M, Ferrari E, Grandi R, Saladini M (2002) Curcuminoids as potential new iron-chelating agents: spectroscopic, polarographic and potentiometric study on their Fe(III) complexing ability. Inorg Chim Acta 328(1):61\u201368. https:\/\/doi.org\/10.1016\/S0020-1693(01)00687-9","journal-title":"Inorg Chim Acta"},{"issue":"4","key":"4321_CR168","doi-asserted-by":"publisher","first-page":"367","DOI":"10.3233\/jad-2004-6403","volume":"6","author":"L Baum","year":"2004","unstructured":"Baum L, Ng A (2004) Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer\u2019s disease animal models. J Alzheimers Dis 6(4):367\u2013377. https:\/\/doi.org\/10.3233\/jad-2004-6403","journal-title":"J Alzheimers Dis"},{"issue":"7","key":"4321_CR169","doi-asserted-by":"publisher","first-page":"2026","DOI":"10.1021\/acs.accounts.9b00248","volume":"52","author":"Y Liu","year":"2019","unstructured":"Liu Y, Nguyen M, Robert A, Meunier B (2019) Metal ions in Alzheimer\u2019s disease: a key role or not? Acc Chem Res 52(7):2026\u20132035. https:\/\/doi.org\/10.1021\/acs.accounts.9b00248","journal-title":"Acc Chem Res"},{"issue":"1","key":"4321_CR170","doi-asserted-by":"publisher","first-page":"2039","DOI":"10.1038\/s41598-018-20179-6","volume":"8","author":"YA Larasati","year":"2018","unstructured":"Larasati YA, Yoneda-Kato N, Nakamae I, Yokoyama T, Meiyanto E, Kato JY (2018) Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth. Sci Rep 8(1):2039. https:\/\/doi.org\/10.1038\/s41598-018-20179-6","journal-title":"Sci Rep"},{"key":"4321_CR171","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.neuro.2017.05.004","volume":"62","author":"AJ Akinyemi","year":"2017","unstructured":"Akinyemi AJ, Oboh G, Fadaka AO, Olatunji BP, Akomolafe S (2017) Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. Neurotoxicology 62:75\u201379. https:\/\/doi.org\/10.1016\/j.neuro.2017.05.004","journal-title":"Neurotoxicology"},{"issue":"6","key":"4321_CR172","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.freeradbiomed.2005.05.005","volume":"39","author":"A Barik","year":"2005","unstructured":"Barik A, Mishra B, Shen L, Mohan H, Kadam RM, Dutta S, Zhang HY, Priyadarsini KI (2005) Evaluation of a new copper(II)-curcumin complex as superoxide dismutase mimic and its free radical reactions. Free Radic Biol Med 39(6):811\u2013822. https:\/\/doi.org\/10.1016\/j.freeradbiomed.2005.05.005","journal-title":"Free Radic Biol Med"},{"key":"4321_CR173","doi-asserted-by":"publisher","unstructured":"Yan FS, Sun JL, Xie WH, Shen L, Ji HF (2017) Neuroprotective effects and mechanisms of curcumin-Cu(II) and -Zn(II) complexes systems and their pharmacological implications. Nutrients 10(1). https:\/\/doi.org\/10.3390\/nu10010028","DOI":"10.3390\/nu10010028"},{"key":"4321_CR174","doi-asserted-by":"publisher","unstructured":"Ege D (2021) Action mechanisms of curcumin in Alzheimer\u2019s disease and its brain targeted delivery. Materials (Basel) 14(12). https:\/\/doi.org\/10.3390\/ma14123332","DOI":"10.3390\/ma14123332"},{"issue":"4","key":"4321_CR175","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.3233\/JAD-170188","volume":"58","author":"M Tang","year":"2017","unstructured":"Tang M, Taghibiglou C (2017) The mechanisms of action of curcumin in Alzheimer\u2019s disease. J Alzheimers Dis 58(4):1003\u20131016. https:\/\/doi.org\/10.3233\/JAD-170188","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"4321_CR176","doi-asserted-by":"publisher","first-page":"843","DOI":"10.3233\/JAD-170512","volume":"61","author":"PH Reddy","year":"2018","unstructured":"Reddy PH, Manczak M, Yin X, Grady MC, Mitchell A, Tonk S, Kuruva CS, Bhatti JS et al (2018) Protective effects of Indian spice curcumin against amyloid-beta in Alzheimer\u2019s disease. J Alzheimers Dis 61(3):843\u2013866. https:\/\/doi.org\/10.3233\/JAD-170512","journal-title":"J Alzheimers Dis"},{"issue":"11","key":"4321_CR177","first-page":"2032","volume":"19","author":"A Noorafshan","year":"2013","unstructured":"Noorafshan A, Ashkani-Esfahani S (2013) A review of therapeutic effects of curcumin. Curr Pharm Des 19(11):2032\u20132046","journal-title":"Curr Pharm Des"},{"issue":"4B","key":"4321_CR178","first-page":"2895","volume":"21","author":"AL Cheng","year":"2001","unstructured":"Cheng AL, Hsu CH, Lin JK, Hsu MM, Ho YF, Shen TS, Ko JY, Lin JT et al (2001) Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21(4B):2895\u20132900","journal-title":"Anticancer Res"},{"issue":"26","key":"4321_CR179","doi-asserted-by":"publisher","first-page":"3089","DOI":"10.1016\/j.lfs.2004.12.021","volume":"76","author":"AH Gilani","year":"2005","unstructured":"Gilani AH, Shah AJ, Ghayur MN, Majeed K (2005) Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders. Life Sci 76(26):3089\u20133105. https:\/\/doi.org\/10.1016\/j.lfs.2004.12.021","journal-title":"Life Sci"},{"issue":"1","key":"4321_CR180","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.reprotox.2012.04.005","volume":"34","author":"CJ Murphy","year":"2012","unstructured":"Murphy CJ, Tang H, Van Kirk EA, Shen Y, Murdoch WJ (2012) Reproductive effects of a pegylated curcumin. Reprod Toxicol 34(1):120\u2013124. https:\/\/doi.org\/10.1016\/j.reprotox.2012.04.005","journal-title":"Reprod Toxicol"},{"issue":"1\u20132","key":"4321_CR181","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/j.jchromb.2007.03.010","volume":"853","author":"KY Yang","year":"2007","unstructured":"Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH (2007) Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS\/MS. J Chromatogr B Analyt Technol Biomed Life Sci 853(1\u20132):183\u2013189. https:\/\/doi.org\/10.1016\/j.jchromb.2007.03.010","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"1","key":"4321_CR182","doi-asserted-by":"publisher","first-page":"2","DOI":"10.4143\/crt.2014.46.1.2","volume":"46","author":"S Prasad","year":"2014","unstructured":"Prasad S, Tyagi AK, Aggarwal BB (2014) Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat 46(1):2\u201318. https:\/\/doi.org\/10.4143\/crt.2014.46.1.2","journal-title":"Cancer Res Treat"},{"issue":"6","key":"4321_CR183","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1158\/1055-9965.EPI-07-2693","volume":"17","author":"SK Vareed","year":"2008","unstructured":"Vareed SK, Kakarala M, Ruffin MT, Crowell JA, Normolle DP, Djuric Z, Brenner DE (2008) Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol Biomarkers Prev 17(6):1411\u20131417. https:\/\/doi.org\/10.1158\/1055-9965.EPI-07-2693","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"4321_CR184","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.colsurfb.2013.06.032","volume":"111","author":"J Sun","year":"2013","unstructured":"Sun J, Bi C, Chan HM, Sun S, Zhang Q, Zheng Y (2013) Curcumin-loaded solid lipid nanoparticles have prolonged in vitro antitumour activity, cellular uptake and improved in vivo bioavailability. Colloids Surf B Biointerfaces 111:367\u2013375. https:\/\/doi.org\/10.1016\/j.colsurfb.2013.06.032","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"4321_CR185","first-page":"115","volume":"8","author":"L Pari","year":"2005","unstructured":"Pari L, Amali DR (2005) Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. J Pharm Pharm Sci 8(1):115\u2013123","journal-title":"J Pharm Pharm Sci"},{"issue":"5","key":"4321_CR186","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.phrs.2003.11.005","volume":"49","author":"L Pari","year":"2004","unstructured":"Pari L, Murugan P (2004) Protective role of tetrahydrocurcumin against erythromycin estolate-induced hepatotoxicity. Pharmacol Res 49(5):481\u2013486. https:\/\/doi.org\/10.1016\/j.phrs.2003.11.005","journal-title":"Pharmacol Res"},{"issue":"3","key":"4321_CR187","first-page":"1058","volume":"61","author":"C Ireson","year":"2001","unstructured":"Ireson C, Orr S, Jones DJ, Verschoyle R, Lim CK, Luo JL, Howells L, Plummer S et al (2001) Characterization of metabolites of the chemopreventive agent curcumin in human and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 61(3):1058\u20131064","journal-title":"Cancer Res"},{"issue":"4","key":"4321_CR188","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1055\/s-2006-957450","volume":"64","author":"G Shoba","year":"1998","unstructured":"Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS (1998) Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64(4):353\u2013356. https:\/\/doi.org\/10.1055\/s-2006-957450","journal-title":"Planta Med"},{"key":"4321_CR189","doi-asserted-by":"publisher","first-page":"485","DOI":"10.3389\/fphar.2016.00485","volume":"7","author":"D Paolino","year":"2016","unstructured":"Paolino D, Vero A, Cosco D, Pecora TM, Cianciolo S, Fresta M, Pignatello R (2016) Improvement of oral bioavailability of curcumin upon microencapsulation with methacrylic copolymers. Front Pharmacol 7:485. https:\/\/doi.org\/10.3389\/fphar.2016.00485","journal-title":"Front Pharmacol"},{"issue":"4","key":"4321_CR190","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/lam.13045","volume":"67","author":"FGM Medeiros","year":"2018","unstructured":"Medeiros FGM, Correia RTP, Dupont S, Beney L, Pedrini MRS (2018) Curcumin and fisetin internalization into Saccharomyces cerevisiae cells via osmoporation: impact of multiple osmotic treatments on the process efficiency. Lett Appl Microbiol 67(4):363\u2013369. https:\/\/doi.org\/10.1111\/lam.13045","journal-title":"Lett Appl Microbiol"},{"issue":"3","key":"4321_CR191","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1016\/j.nano.2016.11.004","volume":"13","author":"C Bi","year":"2017","unstructured":"Bi C, Miao XQ, Chow SF, Wu WJ, Yan R, Liao YH, Chow AH, Zheng Y (2017) Particle size effect of curcumin nanosuspensions on cytotoxicity, cellular internalization, in vivo pharmacokinetics and biodistribution. Nanomedicine 13(3):943\u2013953. https:\/\/doi.org\/10.1016\/j.nano.2016.11.004","journal-title":"Nanomedicine"},{"key":"4321_CR192","doi-asserted-by":"publisher","unstructured":"Duong BH, Truong HN, Phan Nguyen QA, Nguyen Phu TN, Hong Nhan LT (2020) Preparation of curcumin nanosuspension with gum Arabic as a natural stabilizer: process optimization and product characterization. Processes 8(8). https:\/\/doi.org\/10.3390\/pr8080970","DOI":"10.3390\/pr8080970"},{"issue":"7","key":"4321_CR193","doi-asserted-by":"publisher","first-page":"1021","DOI":"10.1016\/j.bcp.2010.06.022","volume":"80","author":"VR Yadav","year":"2010","unstructured":"Yadav VR, Prasad S, Kannappan R, Ravindran J, Chaturvedi MM, Vaahtera L, Parkkinen J, Aggarwal BB (2010) Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake. Biochem Pharmacol 80(7):1021\u20131032. https:\/\/doi.org\/10.1016\/j.bcp.2010.06.022","journal-title":"Biochem Pharmacol"},{"key":"4321_CR194","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.carres.2015.09.013","volume":"418","author":"JQ Zhang","year":"2015","unstructured":"Zhang JQ, Jiang KM, An K, Ren SH, Xie XG, Jin Y, Lin J (2015) Novel water-soluble fisetin\/cyclodextrins inclusion complexes: preparation, characterization, molecular docking and bioavailability. Carbohydr Res 418:20\u201328. https:\/\/doi.org\/10.1016\/j.carres.2015.09.013","journal-title":"Carbohydr Res"},{"key":"4321_CR195","doi-asserted-by":"publisher","first-page":"879","DOI":"10.3389\/fbioe.2020.00879","volume":"8","author":"T Gupta","year":"2020","unstructured":"Gupta T, Singh J, Kaur S, Sandhu S, Singh G, Kaur IP (2020) Enhancing bioavailability and stability of curcumin using solid lipid nanoparticles (CLEN): a covenant for its effectiveness. Front Bioeng Biotechnol 8:879. https:\/\/doi.org\/10.3389\/fbioe.2020.00879","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"4321_CR196","doi-asserted-by":"publisher","first-page":"19110","DOI":"10.1038\/s41598-023-46215-8","volume":"13","author":"RH Awadeen","year":"2023","unstructured":"Awadeen RH, Boughdady MF, Zaghloul RA, Elsaed WM, Abu H II, Meshali MM (2023) Formulation of lipid polymer hybrid nanoparticles of the phytochemical fisetin and its in vivo assessment against severe acute pancreatitis. Sci Rep 13(1):19110. https:\/\/doi.org\/10.1038\/s41598-023-46215-8","journal-title":"Sci Rep"},{"key":"4321_CR197","doi-asserted-by":"publisher","unstructured":"Rosiak N, Tykarska E, Cielecka-Piontek J (2024) Mechanochemical approach to obtaining a multicomponent fisetin delivery system improving its solubility and biological activity. Int J Mol Sci 25(7). https:\/\/doi.org\/10.3390\/ijms25073648","DOI":"10.3390\/ijms25073648"},{"key":"4321_CR198","doi-asserted-by":"publisher","unstructured":"Mai NNS, Nakai R, Kawano Y, Hanawa T (2020) Enhancing the solubility of curcumin using a solid dispersion system with hydroxypropyl-beta-cyclodextrin prepared by grinding, freeze-drying, and common solvent evaporation methods. Pharmacy (Basel) 8(4). https:\/\/doi.org\/10.3390\/pharmacy8040203","DOI":"10.3390\/pharmacy8040203"},{"key":"4321_CR199","doi-asserted-by":"crossref","unstructured":"Lund KC, Pantuso T (2014) Combination effects of quercetin, resveratrol and curcumin on in vitro intestinal absorption. In","DOI":"10.14200\/jrm.2014.3.0108"},{"issue":"1","key":"4321_CR200","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1186\/s13020-022-00660-1","volume":"17","author":"P Boonrueng","year":"2022","unstructured":"Boonrueng P, Wasana PWD, Hasriadi VO, Rojsitthisak P, Towiwat P (2022) Combination of curcumin and piperine synergistically improves pain-like behaviors in mouse models of pain with no potential CNS side effects. Chin Med 17(1):119. https:\/\/doi.org\/10.1186\/s13020-022-00660-1","journal-title":"Chin Med"},{"key":"4321_CR201","doi-asserted-by":"publisher","first-page":"487","DOI":"10.3389\/fphar.2020.00487","volume":"11","author":"A Karthikeyan","year":"2020","unstructured":"Karthikeyan A, Senthil N, Min T (2020) Nanocurcumin: a promising candidate for therapeutic applications. Front Pharmacol 11:487. https:\/\/doi.org\/10.3389\/fphar.2020.00487","journal-title":"Front Pharmacol"},{"key":"4321_CR202","doi-asserted-by":"publisher","unstructured":"Lo Cascio F, Marzullo P, Kayed R, Palumbo Piccionello A (2021) Curcumin as scaffold for drug discovery against neurodegenerative diseases. Biomedicines 9(2). https:\/\/doi.org\/10.3390\/biomedicines9020173","DOI":"10.3390\/biomedicines9020173"},{"key":"4321_CR203","doi-asserted-by":"publisher","first-page":"8507","DOI":"10.2147\/IJN.S183117","volume":"13","author":"C Ross","year":"2018","unstructured":"Ross C, Taylor M, Fullwood N, Allsop D (2018) Liposome delivery systems for the treatment of Alzheimer\u2019s disease. Int J Nanomedicine 13:8507\u20138522. https:\/\/doi.org\/10.2147\/IJN.S183117","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"4321_CR204","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1186\/s11671-018-2759-z","volume":"13","author":"R Yang","year":"2018","unstructured":"Yang R, Zheng Y, Wang Q, Zhao L (2018) Curcumin-loaded chitosan-bovine serum albumin nanoparticles potentially enhanced Abeta 42 phagocytosis and modulated macrophage polarization in Alzheimer\u2019s disease. Nanoscale Res Lett 13(1):330. https:\/\/doi.org\/10.1186\/s11671-018-2759-z","journal-title":"Nanoscale Res Lett"},{"key":"4321_CR205","doi-asserted-by":"publisher","first-page":"146325","DOI":"10.1016\/j.brainres.2019.146325","volume":"1721","author":"R Giacomeli","year":"2019","unstructured":"Giacomeli R, Izoton JC, Dos Santos RB, Boeira SP, Jesse CR, Haas SE (2019) Neuroprotective effects of curcumin lipid-core nanocapsules in a model Alzheimer\u2019s disease induced by beta-amyloid 1\u201342 peptide in aged female mice. Brain Res 1721:146325. https:\/\/doi.org\/10.1016\/j.brainres.2019.146325","journal-title":"Brain Res"},{"issue":"3","key":"4321_CR206","doi-asserted-by":"publisher","first-page":"671","DOI":"10.3233\/JAD-190083","volume":"69","author":"S Sadegh Malvajerd","year":"2019","unstructured":"Sadegh Malvajerd S, Izadi Z, Azadi A, Kurd M, Derakhshankhah H, Sharifzadeh M, Akbari Javar H, Hamidi M (2019) Neuroprotective potential of curcumin-loaded nanostructured lipid carrier in an animal model of Alzheimer\u2019s disease: behavioral and biochemical evidence. J Alzheimers Dis 69(3):671\u2013686. https:\/\/doi.org\/10.3233\/JAD-190083","journal-title":"J Alzheimers Dis"},{"key":"4321_CR207","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.neuroscience.2019.09.032","volume":"423","author":"EM Fidelis","year":"2019","unstructured":"Fidelis EM, Savall ASP, da Luz AE, Carvalho F, Teixeira FEG, Haas SE, Bazanella Sampaio T, Pinton S (2019) Curcumin-loaded nanocapsules reverses the depressant-like behavior and oxidative stress induced by beta-amyloid in mice. Neuroscience 423:122\u2013130. https:\/\/doi.org\/10.1016\/j.neuroscience.2019.09.032","journal-title":"Neuroscience"},{"key":"4321_CR208","doi-asserted-by":"publisher","unstructured":"Shabbir U, Rubab M, Tyagi A, Oh DH (2020) Curcumin and its derivatives as theranostic agents in Alzheimer\u2019s disease: the implication of nanotechnology. Int J Mol Sci 22(1). https:\/\/doi.org\/10.3390\/ijms22010196","DOI":"10.3390\/ijms22010196"},{"key":"4321_CR209","doi-asserted-by":"publisher","unstructured":"Szymczak J, Cielecka-Piontek J (2023) Fisetin-in search of better bioavailability-from macro to nano modifications: a review. Int J Mol Sci 24(18). https:\/\/doi.org\/10.3390\/ijms241814158","DOI":"10.3390\/ijms241814158"},{"issue":"1","key":"4321_CR210","doi-asserted-by":"publisher","first-page":"81","DOI":"10.22038\/IJBMS.2023.73124.15892","volume":"27","author":"YA Khadrawy","year":"2024","unstructured":"Khadrawy YA, Hosny EN, Eldein Mohamed HS (2024) Assessment of the neuroprotective effect of green synthesized iron oxide nanoparticles capped with curcumin against a rat model of Parkinson\u2019s disease. Iran J Basic Med Sci 27(1):81\u201389. https:\/\/doi.org\/10.22038\/IJBMS.2023.73124.15892","journal-title":"Iran J Basic Med Sci"},{"key":"4321_CR211","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.semcancer.2021.06.020","volume":"76","author":"S Medici","year":"2021","unstructured":"Medici S, Peana M, Pelucelli A, Zoroddu MA (2021) An updated overview on metal nanoparticles toxicity. Semin Cancer Biol 76:17\u201326. https:\/\/doi.org\/10.1016\/j.semcancer.2021.06.020","journal-title":"Semin Cancer Biol"},{"key":"4321_CR212","doi-asserted-by":"publisher","unstructured":"Panzarini E, Mariano S, Tacconi S, Carata E, Tata AM, Dini L (2020) Novel therapeutic delivery of nanocurcumin in central nervous system related disorders. Nanomaterials (Basel) 11(1). https:\/\/doi.org\/10.3390\/nano11010002","DOI":"10.3390\/nano11010002"},{"issue":"5","key":"4321_CR213","doi-asserted-by":"publisher","first-page":"2056","DOI":"10.1021\/jf104402t","volume":"59","author":"BRK Bhawana","year":"2011","unstructured":"Bhawana BRK, Buttar HS, Jain VK, Jain N (2011) Curcumin nanoparticles: preparation, characterization, and antimicrobial study. J Agric Food Chem 59(5):2056\u20132061. https:\/\/doi.org\/10.1021\/jf104402t","journal-title":"J Agric Food Chem"},{"issue":"12","key":"4321_CR214","doi-asserted-by":"publisher","first-page":"8246","DOI":"10.1021\/acsomega.0c06314","volume":"6","author":"SS Hettiarachchi","year":"2021","unstructured":"Hettiarachchi SS, Dunuweera SP, Dunuweera AN, Rajapakse RMG (2021) Synthesis of curcumin nanoparticles from raw turmeric rhizome. ACS Omega 6(12):8246\u20138252. https:\/\/doi.org\/10.1021\/acsomega.0c06314","journal-title":"ACS Omega"},{"key":"4321_CR215","doi-asserted-by":"publisher","unstructured":"Attaluri S, Arora M, Madhu LN, Kodali M, Shuai B, Melissari L, Upadhya R, Rao X et al (2022) Oral nano-curcumin in a model of chronic gulf war illness alleviates brain dysfunction with modulation of oxidative stress, mitochondrial function, neuroinflammation, neurogenesis, and gene expression. Aging Dis 13(2):583\u2013613. https:\/\/doi.org\/10.14336\/AD.2021.0829","DOI":"10.14336\/AD.2021.0829"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04321-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04321-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04321-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T22:11:55Z","timestamp":1736374315000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04321-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,6]]},"references-count":215,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["4321"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04321-2","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,6]]},"assertion":[{"value":"28 December 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics Approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to Participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}},{"value":"The authors declare no competing interests.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}}]}}