{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T04:20:42Z","timestamp":1791951642773,"version":"4.3.4"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T00:00:00Z","timestamp":1721606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020898","name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020898","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Mol Neurobiol"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1007\/s12035-024-04360-9","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T13:02:01Z","timestamp":1721653321000},"page":"1788-1799","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Calorie Restriction Attenuates Memory Impairment and Reduces Neuroinflammation in Obese Aged Rats"],"prefix":"10.1007","volume":"62","author":[{"given":"Jeferson","family":"Jantsch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"da Silva Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Silva Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"de Farias Fraga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Eller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia","family":"Giovenardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Padilha","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,7,22]]},"reference":[{"key":"4360_CR1","doi-asserted-by":"publisher","first-page":"1027","DOI":"10.1016\/S0140-6736(23)02750-2","volume":"403","author":"NCD Risk Factor Collaboration","year":"2024","unstructured":"NCD Risk Factor Collaboration (2024) Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 403:1027\u20131050. https:\/\/doi.org\/10.1016\/S0140-6736(23)02750-2","journal-title":"Lancet"},{"key":"4360_CR2","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.ecl.2022.10.001","volume":"52","author":"N Malandrino","year":"2023","unstructured":"Malandrino N, Bhat SZ, Alfaraidhy M et al (2023) Obesity and aging. Endocrinol Metab Clin North Am 52:317\u2013339. https:\/\/doi.org\/10.1016\/j.ecl.2022.10.001","journal-title":"Endocrinol Metab Clin North Am"},{"key":"4360_CR3","doi-asserted-by":"publisher","first-page":"104833","DOI":"10.1016\/j.archger.2022.104833","volume":"104","author":"S Chen","year":"2023","unstructured":"Chen S, Ling J, Cheng Y (2023) Physical activity and body mass index were interactively related to health-related quality of life among older adults. Arch Gerontol Geriatr 104:104833. https:\/\/doi.org\/10.1016\/j.archger.2022.104833","journal-title":"Arch Gerontol Geriatr"},{"key":"4360_CR4","doi-asserted-by":"publisher","first-page":"155217","DOI":"10.1016\/j.metabol.2022.155217","volume":"133","author":"C Boutari","year":"2022","unstructured":"Boutari C, Mantzoros CS (2022) A 2022 update on the epidemiology of obesity and a call to action: as its twin COVID-19 pandemic appears to be receding, the obesity and dysmetabolism pandemic continues to rage on. Metabolism 133:155217. https:\/\/doi.org\/10.1016\/j.metabol.2022.155217","journal-title":"Metabolism"},{"key":"4360_CR5","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","volume":"25","author":"D Furman","year":"2019","unstructured":"Furman D, Campisi J, Verdin E et al (2019) Chronic inflammation in the etiology of disease across the life span. Nat Med 25:1822\u20131832. https:\/\/doi.org\/10.1038\/s41591-019-0675-0","journal-title":"Nat Med"},{"key":"4360_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41418-022-01062-4","volume":"30","author":"X Hildebrandt","year":"2022","unstructured":"Hildebrandt X, Ibrahim M, Peltzer N (2022) Cell death and inflammation during obesity: \u201cKnow my methods, WAT(son).\u201d Cell Death Differ 30:279\u2013292. https:\/\/doi.org\/10.1038\/s41418-022-01062-4","journal-title":"Cell Death Differ"},{"key":"4360_CR7","doi-asserted-by":"publisher","first-page":"1025706","DOI":"10.3389\/fendo.2022.1025706","volume":"13","author":"Z Cheng","year":"2022","unstructured":"Cheng Z, Zhang L, Yang L, Chu H (2022) The critical role of gut microbiota in obesity. Front Endocrinol 13:1025706. https:\/\/doi.org\/10.3389\/fendo.2022.1025706","journal-title":"Front Endocrinol"},{"issue":"3","key":"4360_CR8","doi-asserted-by":"publisher","first-page":"2719","DOI":"10.3390\/ijms24032719","volume":"24","author":"M Pinti","year":"2023","unstructured":"Pinti M, Gibellini L, Lo Tartaro D et al (2023) A comprehensive analysis of cytokine network in centenarians. Int J Mol Sci 24(3):2719. https:\/\/doi.org\/10.3390\/ijms24032719","journal-title":"Int J Mol Sci"},{"key":"4360_CR9","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","volume":"14","author":"C Franceschi","year":"2018","unstructured":"Franceschi C, Garagnani P, Parini P et al (2018) Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol 14:576\u2013590. https:\/\/doi.org\/10.1038\/s41574-018-0059-4","journal-title":"Nat Rev Endocrinol"},{"key":"4360_CR10","doi-asserted-by":"publisher","first-page":"105766","DOI":"10.1016\/j.nbd.2022.105766","volume":"170","author":"RE Henn","year":"2022","unstructured":"Henn RE, Noureldein MH, Elzinga SE et al (2022) Glial-neuron crosstalk in health and disease: a focus on metabolism, obesity, and cognitive impairment. Neurobiol Dis 170:105766. https:\/\/doi.org\/10.1016\/j.nbd.2022.105766","journal-title":"Neurobiol Dis"},{"key":"4360_CR11","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1186\/s12979-022-00323-7","volume":"19","author":"RE Henn","year":"2022","unstructured":"Henn RE, Elzinga SE, Glass E et al (2022) Obesity-induced neuroinflammation and cognitive impairment in young adult versus middle-aged mice. Immun Ageing 19:67. https:\/\/doi.org\/10.1186\/s12979-022-00323-7","journal-title":"Immun Ageing"},{"key":"4360_CR12","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1210\/endrev\/bnac023","volume":"44","author":"LE Sewaybricker","year":"2023","unstructured":"Sewaybricker LE, Huang A, Chandrasekaran S et al (2023) The significance of hypothalamic inflammation and gliosis for the pathogenesis of obesity in humans. Endocr Rev 44:281\u2013296. https:\/\/doi.org\/10.1210\/endrev\/bnac023","journal-title":"Endocr Rev"},{"key":"4360_CR13","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40035-020-00221-2","volume":"9","author":"HS Kwon","year":"2020","unstructured":"Kwon HS, Koh S-H (2020) Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Transl Neurodegener 9:42. https:\/\/doi.org\/10.1186\/s40035-020-00221-2","journal-title":"Transl Neurodegener"},{"key":"4360_CR14","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1186\/s12974-024-03104-9","volume":"21","author":"Z Feng","year":"2024","unstructured":"Feng Z, Fang C, Ma Y, Chang J (2024) Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms. J Neuroinflammation 21:110. https:\/\/doi.org\/10.1186\/s12974-024-03104-9","journal-title":"J Neuroinflammation"},{"key":"4360_CR15","doi-asserted-by":"publisher","first-page":"165767","DOI":"10.1016\/j.bbadis.2020.165767","volume":"1866","author":"S-J Leigh","year":"2020","unstructured":"Leigh S-J, Morris MJ (2020) Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment. Biochim Biophys Acta Mol Basis Dis 1866:165767. https:\/\/doi.org\/10.1016\/j.bbadis.2020.165767","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"4360_CR16","doi-asserted-by":"publisher","first-page":"113125","DOI":"10.1016\/j.bbr.2021.113125","volume":"402","author":"M-L Wu","year":"2021","unstructured":"Wu M-L, Yang X-Q, Xue L et al (2021) Age-related cognitive decline is associated with microbiota-gut-brain axis disorders and neuroinflammation in mice. Behav Brain Res 402:113125. https:\/\/doi.org\/10.1016\/j.bbr.2021.113125","journal-title":"Behav Brain Res"},{"issue":"17","key":"4360_CR17","doi-asserted-by":"publisher","first-page":"5964","DOI":"10.3390\/ijms21175964","volume":"21","author":"M Crispino","year":"2020","unstructured":"Crispino M, Trinchese G, Penna E et al (2020) Interplay between peripheral and central inflammation in obesity-promoted disorders: the impact on synaptic mitochondrial functions. Int J Mol Sci 21(17):5964. https:\/\/doi.org\/10.3390\/ijms21175964","journal-title":"Int J Mol Sci"},{"key":"4360_CR18","doi-asserted-by":"publisher","first-page":"798995","DOI":"10.3389\/fnint.2022.798995","volume":"16","author":"V Salas-Venegas","year":"2022","unstructured":"Salas-Venegas V, Flores-Torres RP, Rodr\u00edguez-Cort\u00e9s YM et al (2022) The obese brain: mechanisms of systemic and local inflammation, and interventions to reverse the cognitive deficit. Front Integr Neurosci 16:798995. https:\/\/doi.org\/10.3389\/fnint.2022.798995","journal-title":"Front Integr Neurosci"},{"key":"4360_CR19","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1111\/jgs.16321","volume":"68","author":"M Ganguli","year":"2020","unstructured":"Ganguli M, Beer JC, Zmuda JM et al (2020) Aging, diabetes, obesity, and cognitive decline: a population-based study. J Am Geriatr Soc 68:991\u2013998. https:\/\/doi.org\/10.1111\/jgs.16321","journal-title":"J Am Geriatr Soc"},{"issue":"2","key":"4360_CR20","doi-asserted-by":"publisher","first-page":"e20190086","DOI":"10.1084\/jem.20190086","volume":"218","author":"L Fontana","year":"2021","unstructured":"Fontana L, Ghezzi L, Cross AH, Piccio L (2021) Effects of dietary restriction on neuroinflammation in neurodegenerative diseases. J Exp Med 218(2):e20190086. https:\/\/doi.org\/10.1084\/jem.20190086","journal-title":"J Exp Med"},{"key":"4360_CR21","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1146\/annurev-nutr-122319-034601","volume":"40","author":"EW Flanagan","year":"2020","unstructured":"Flanagan EW, Most J, Mey JT, Redman LM (2020) Calorie restriction and aging in humans. Annu Rev Nutr 40:105\u2013133. https:\/\/doi.org\/10.1146\/annurev-nutr-122319-034601","journal-title":"Annu Rev Nutr"},{"key":"4360_CR22","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S2213-8587(19)30151-2","volume":"7","author":"WE Kraus","year":"2019","unstructured":"Kraus WE, Bhapkar M, Huffman KM et al (2019) 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial. Lancet Diabetes Endocrinol 7:673\u2013683. https:\/\/doi.org\/10.1016\/S2213-8587(19)30151-2","journal-title":"Lancet Diabetes Endocrinol"},{"key":"4360_CR23","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.brainresbull.2015.06.004","volume":"116","author":"L Ma","year":"2015","unstructured":"Ma L, Dong W, Wang R et al (2015) Effect of caloric restriction on the SIRT1\/mTOR signaling pathways in senile mice. Brain Res Bull 116:67\u201372. https:\/\/doi.org\/10.1016\/j.brainresbull.2015.06.004","journal-title":"Brain Res Bull"},{"key":"4360_CR24","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00394-022-03036-1","volume":"62","author":"B Zhang","year":"2023","unstructured":"Zhang B, Huang R, Xu S et al (2023) Dietary energy restriction in neurological diseases: what\u2019s new? Eur J Nutr 62:573\u2013588. https:\/\/doi.org\/10.1007\/s00394-022-03036-1","journal-title":"Eur J Nutr"},{"key":"4360_CR25","doi-asserted-by":"publisher","first-page":"6464","DOI":"10.1039\/d0fo02946g","volume":"12","author":"R Wang","year":"2021","unstructured":"Wang R, Zhou Z, Wang D et al (2021) Caloric restriction ameliorates high-fat diet induced cognitive deficits through attenuating neuroinflammation via the TREM2-PI3K\/AKT signaling pathway. Food Funct 12:6464\u20136478. https:\/\/doi.org\/10.1039\/d0fo02946g","journal-title":"Food Funct"},{"key":"4360_CR26","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/oby.23024","volume":"29","author":"S de Oliveira","year":"2021","unstructured":"de Oliveira S, Feij\u00f3 GDS, Neto J et al (2021) Zinc supplementation decreases obesity-related neuroinflammation and improves metabolic function and memory in rats. Obesity 29:116\u2013124. https:\/\/doi.org\/10.1002\/oby.23024","journal-title":"Obesity"},{"key":"4360_CR27","doi-asserted-by":"publisher","unstructured":"Neto J, Jantsch J, de Oliveira S, et al (2021) DHA\/EPA supplementation decreases anxiety-like behaviour, but it does not ameliorate metabolic profile in obese male rats. Br J Nutr 1\u201311. https:\/\/doi.org\/10.1017\/S0007114521003998","DOI":"10.1017\/S0007114521003998"},{"key":"4360_CR28","doi-asserted-by":"publisher","first-page":"109371","DOI":"10.1016\/j.jnutbio.2023.109371","volume":"119","author":"J Jantsch","year":"2023","unstructured":"Jantsch J, da Rodrigues FS, de Fraga GF et al (2023) Calorie restriction mitigates metabolic, behavioral and neurochemical effects of cafeteria diet in aged male rats. J Nutr Biochem 119:109371. https:\/\/doi.org\/10.1016\/j.jnutbio.2023.109371","journal-title":"J Nutr Biochem"},{"key":"4360_CR29","doi-asserted-by":"publisher","first-page":"1150189","DOI":"10.3389\/fnut.2023.1150189","volume":"10","author":"F Rodrigues","year":"2023","unstructured":"Rodrigues F, Jantsch J, Fraga G et al (2023) Cannabidiol treatment improves metabolic profile and decreases hypothalamic inflammation caused by maternal obesity. Front Nutr 10:1150189. https:\/\/doi.org\/10.3389\/fnut.2023.1150189","journal-title":"Front Nutr"},{"key":"4360_CR30","doi-asserted-by":"publisher","first-page":"e5487","DOI":"10.1002\/bmc.5487","volume":"36","author":"RR Viana","year":"2022","unstructured":"Viana RR, Pego AMF, de Oliveira TF et al (2022) Liquid chromatography-tandem mass spectrometry method for simultaneous quantification of neurotransmitters in rat brain tissue exposed to 4\u2019-fluoro-\u03b1-PHP. Biomed Chromatogr 36:e5487. https:\/\/doi.org\/10.1002\/bmc.5487","journal-title":"Biomed Chromatogr"},{"key":"4360_CR31","doi-asserted-by":"publisher","first-page":"2505","DOI":"10.1038\/s41467-019-10484-7","volume":"10","author":"C Kosse","year":"2019","unstructured":"Kosse C, Burdakov D (2019) Natural hypothalamic circuit dynamics underlying object memorization. Nat Commun 10:2505. https:\/\/doi.org\/10.1038\/s41467-019-10484-7","journal-title":"Nat Commun"},{"key":"4360_CR32","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.cmet.2022.09.002","volume":"34","author":"D Herrera Moro Chao","year":"2022","unstructured":"Herrera Moro Chao D, Kirchner MK, Pham C et al (2022) Hypothalamic astrocytes control systemic glucose metabolism and energy balance. Cell Metab 34:1532-1547.e6. https:\/\/doi.org\/10.1016\/j.cmet.2022.09.002","journal-title":"Cell Metab"},{"key":"4360_CR33","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.1007\/s11011-022-00996-5","volume":"37","author":"GDS Feij\u00f3","year":"2022","unstructured":"Feij\u00f3 GDS, Jantsch J, Correia LL et al (2022) Neuroinflammatory responses following zinc or branched-chain amino acids supplementation in obese rats. Metab Brain Dis 37:1875\u20131886. https:\/\/doi.org\/10.1007\/s11011-022-00996-5","journal-title":"Metab Brain Dis"},{"key":"4360_CR34","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.neurobiolaging.2017.06.014","volume":"58","author":"SJ Spencer","year":"2017","unstructured":"Spencer SJ, D\u2019Angelo H, Soch A et al (2017) High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory. Neurobiol Aging 58:88\u2013101. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.06.014","journal-title":"Neurobiol Aging"},{"key":"4360_CR35","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/s41538-023-00211-4","volume":"7","author":"BM Gonz\u00e1lez Olmo","year":"2023","unstructured":"Gonz\u00e1lez Olmo BM, Bettes MN, DeMarsh JW et al (2023) Short-term high-fat diet consumption impairs synaptic plasticity in the aged hippocampus via IL-1 signaling. NPJ Sci Food 7:35. https:\/\/doi.org\/10.1038\/s41538-023-00211-4","journal-title":"NPJ Sci Food"},{"key":"4360_CR36","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.bbi.2014.06.017","volume":"42","author":"JL Sobesky","year":"2014","unstructured":"Sobesky JL, Barrientos RM, De May HS et al (2014) High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1\u03b2, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism. Brain Behav Immun 42:22\u201332. https:\/\/doi.org\/10.1016\/j.bbi.2014.06.017","journal-title":"Brain Behav Immun"},{"key":"4360_CR37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","volume":"60","author":"A Varatharaj","year":"2017","unstructured":"Varatharaj A, Galea I (2017) The blood-brain barrier in systemic inflammation. Brain Behav Immun 60:1\u201312. https:\/\/doi.org\/10.1016\/j.bbi.2016.03.010","journal-title":"Brain Behav Immun"},{"issue":"Suppl 1","key":"4360_CR38","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1111\/cns.14301","volume":"29","author":"T Inaba","year":"2023","unstructured":"Inaba T, Yamashiro K, Kurita N et al (2023) Microbial lipopolysaccharide-induced inflammation contributes to cognitive impairment and white matter lesion progression in diet-induced obese mice with chronic cerebral hypoperfusion. CNS Neurosci Ther 29(Suppl 1):200\u2013212. https:\/\/doi.org\/10.1111\/cns.14301","journal-title":"CNS Neurosci Ther"},{"key":"4360_CR39","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/j.neurobiolaging.2021.02.012","volume":"103","author":"BM Bettcher","year":"2021","unstructured":"Bettcher BM, Olson KE, Carlson NE et al (2021) Astrogliosis and episodic memory in late life: higher GFAP is related to worse memory and white matter microstructure in healthy aging and Alzheimer\u2019s disease. Neurobiol Aging 103:68\u201377. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2021.02.012","journal-title":"Neurobiol Aging"},{"key":"4360_CR40","doi-asserted-by":"publisher","first-page":"109653","DOI":"10.1016\/j.intimp.2022.109653","volume":"115","author":"M-H Lin","year":"2023","unstructured":"Lin M-H, Cheng P-C, Hsiao P-J et al (2023) The GLP-1 receptor agonist exenatide ameliorates neuroinflammation, locomotor activity, and anxiety-like behavior in mice with diet-induced obesity through the modulation of microglial M2 polarization and downregulation of SR-A4. Int Immunopharmacol 115:109653. https:\/\/doi.org\/10.1016\/j.intimp.2022.109653","journal-title":"Int Immunopharmacol"},{"key":"4360_CR41","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1002\/glia.22930","volume":"64","author":"DM Norden","year":"2016","unstructured":"Norden DM, Trojanowski PJ, Villanueva E et al (2016) Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge. Glia 64:300\u2013316. https:\/\/doi.org\/10.1002\/glia.22930","journal-title":"Glia"},{"key":"4360_CR42","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1080\/1028415X.2022.2068876","volume":"26","author":"W L\u00fc","year":"2023","unstructured":"L\u00fc W, Yu T, Kuang W (2023) Effects of dietary restriction on cognitive function: a systematic review and meta-analysis. Nutr Neurosci 26:540\u2013550. https:\/\/doi.org\/10.1080\/1028415X.2022.2068876","journal-title":"Nutr Neurosci"},{"issue":"3","key":"4360_CR43","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3390\/brainsci13030462","volume":"13","author":"L Wei","year":"2023","unstructured":"Wei L, Tao Q, Yao M et al (2023) Caloric restriction can ameliorate postoperative cognitive dysfunction by upregulating the expression of Sirt1, MeCP2 and BDNF in the hippocampal CA1 region of aged C57BL\/6 mice. Brain Sci 13(3):462. https:\/\/doi.org\/10.3390\/brainsci13030462","journal-title":"Brain Sci"},{"key":"4360_CR44","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s12974-021-02250-8","volume":"18","author":"Y Zhao","year":"2021","unstructured":"Zhao Y, Zhang J, Zheng Y et al (2021) NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1\/PGC-1\u03b1 pathway. J Neuroinflammation 18:207. https:\/\/doi.org\/10.1186\/s12974-021-02250-8","journal-title":"J Neuroinflammation"},{"key":"4360_CR45","doi-asserted-by":"publisher","first-page":"108579","DOI":"10.1016\/j.jnutbio.2020.108579","volume":"90","author":"X le Tang","year":"2021","unstructured":"le Tang X, Wang X, Fang G et al (2021) Resveratrol ameliorates sevoflurane-induced cognitive impairment by activating the SIRT1\/NF-\u03baB pathway in neonatal mice. J Nutr Biochem 90:108579. https:\/\/doi.org\/10.1016\/j.jnutbio.2020.108579","journal-title":"J Nutr Biochem"},{"key":"4360_CR46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/s40659-016-0075-6","volume":"49","author":"C Sandoval-Salazar","year":"2016","unstructured":"Sandoval-Salazar C, Ram\u00edrez-Emiliano J, Trejo-Bahena A et al (2016) A high-fat diet decreases GABA concentration in the frontal cortex and hippocampus of rats. Biol Res 49:15. https:\/\/doi.org\/10.1186\/s40659-016-0075-6","journal-title":"Biol Res"},{"key":"4360_CR47","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/j.molmed.2015.05.002","volume":"21","author":"JA McQuail","year":"2015","unstructured":"McQuail JA, Frazier CJ, Bizon JL (2015) Molecular aspects of age-related cognitive decline: the role of GABA signaling. Trends Mol Med 21:450\u2013460. https:\/\/doi.org\/10.1016\/j.molmed.2015.05.002","journal-title":"Trends Mol Med"},{"key":"4360_CR48","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.semcdb.2021.01.005","volume":"116","author":"J Jim\u00e9nez-Balado","year":"2021","unstructured":"Jim\u00e9nez-Balado J, Eich TS (2021) GABAergic dysfunction, neural network hyperactivity and memory impairments in human aging and Alzheimer\u2019s disease. Semin Cell Dev Biol 116:146\u2013159. https:\/\/doi.org\/10.1016\/j.semcdb.2021.01.005","journal-title":"Semin Cell Dev Biol"},{"issue":"8","key":"4360_CR49","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.3390\/ijms18081813","volume":"18","author":"K Govindpani","year":"2017","unstructured":"Govindpani K, Calvo-Flores Guzm\u00e1n B, Vinnakota C et al (2017) Towards a better understanding of GABAergic remodeling in Alzheimer\u2019s disease. Int J Mol Sci 18(8):1813. https:\/\/doi.org\/10.3390\/ijms18081813","journal-title":"Int J Mol Sci"},{"key":"4360_CR50","doi-asserted-by":"publisher","first-page":"111248","DOI":"10.1016\/j.mad.2020.111248","volume":"189","author":"A Chakraborty","year":"2020","unstructured":"Chakraborty A, Banerjee S, Mukherjee B, Poddar MK (2020) Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. Mech Ageing Dev 189:111248. https:\/\/doi.org\/10.1016\/j.mad.2020.111248","journal-title":"Mech Ageing Dev"},{"key":"4360_CR51","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bbi.2014.04.001","volume":"42","author":"AA Miller","year":"2014","unstructured":"Miller AA, Spencer SJ (2014) Obesity and neuroinflammation: a pathway to cognitive impairment. Brain Behav Immun 42:10\u201321. https:\/\/doi.org\/10.1016\/j.bbi.2014.04.001","journal-title":"Brain Behav Immun"},{"issue":"2","key":"4360_CR52","doi-asserted-by":"publisher","first-page":"498","DOI":"10.3390\/nu13020498","volume":"13","author":"S Dionysopoulou","year":"2021","unstructured":"Dionysopoulou S, Charmandari E, Bargiota A et al (2021) The role of hypothalamic inflammation in diet-induced obesity and its association with cognitive and mood disorders. Nutrients 13(2):498. https:\/\/doi.org\/10.3390\/nu13020498","journal-title":"Nutrients"},{"key":"4360_CR53","doi-asserted-by":"publisher","first-page":"140","DOI":"10.3109\/13813455.2011.577435","volume":"117","author":"D Horrillo","year":"2011","unstructured":"Horrillo D, Sierra J, Arribas C et al (2011) Age-associated development of inflammation in Wistar rats: effects of caloric restriction. Arch Physiol Biochem 117:140\u2013150. https:\/\/doi.org\/10.3109\/13813455.2011.577435","journal-title":"Arch Physiol Biochem"}],"container-title":["Molecular Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04360-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s12035-024-04360-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s12035-024-04360-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T08:32:33Z","timestamp":1737966753000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s12035-024-04360-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,22]]},"references-count":53,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["4360"],"URL":"https:\/\/doi.org\/10.1007\/s12035-024-04360-9","relation":{},"ISSN":["0893-7648","1559-1182"],"issn-type":[{"value":"0893-7648","type":"print"},{"value":"1559-1182","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,22]]},"assertion":[{"value":"12 January 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 July 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing Interests"}}]}}